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FREDERICK HAUSHEER

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Kojiro Shimozuma; Kimito Suemasu; Ayano Takeuchi; Toru Watanabe; Noriyuki Katsumata; Masaru Kuranami; Katsumasa Kuroi; Haruhiko Makino; Satoshi Morita; Yasuo Ohashi; Shozo Ohsumi; Toshihiko Aranishi; FREDERICK HAUSHEER
Taxane-induced peripheral neuropathy and health-related quality of life in postoperative breast cancer patients undergoing adjuvant chemotherapy: N-SAS BC 02, a randomized clinical trial.
FREDERICK HAUSHEER; Q Huang; H Kochat; B D Leverett; P Y Ayala; X Chen; D Ding; Pavankumar N Petluru; D Shanmugarajah; A R Parker
Accumulation of BNP7787 in human renal proximal tubule cells.
Noriyuki Masuda; Shunichi Negoro; FREDERICK HAUSHEER; Kazuhiko Nakagawa; Kaoru Matsui; Shinzoh Kudoh; Koji Takeda; Nobuyuki Yamamoto; Naruo Yoshimura; Yasuo Ohashi; Masahiro Fukuoka
Phase I and pharmacologic study of BNP7787, a novel chemoprotector in patients with advanced non-small cell lung cancer.

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All Publications

2012: Kojiro Shimozuma; Kimito Suemasu; Ayano Takeuchi; Toru Watanabe; Noriyuki Katsumata; Masaru Kuranami; Katsumasa Kuroi; Haruhiko Makino; Satoshi Morita; Yasuo Ohashi; Shozo Ohsumi; Toshihiko Aranishi; FREDERICK HAUSHEER
Taxane-induced peripheral neuropathy and health-related quality of life in postoperative breast cancer patients undergoing adjuvant chemotherapy: N-SAS BC 02, a randomized clinical trial.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2012;20(12):3355-64.
2011: FREDERICK HAUSHEER; Q Huang; H Kochat; B D Leverett; P Y Ayala; X Chen; D Ding; Pavankumar N Petluru; D Shanmugarajah; A R Parker
Accumulation of BNP7787 in human renal proximal tubule cells.
Journal of pharmaceutical sciences 2011;100(9):3977-84.
2011: Noriyuki Masuda; Shunichi Negoro; FREDERICK HAUSHEER; Kazuhiko Nakagawa; Kaoru Matsui; Shinzoh Kudoh; Koji Takeda; Nobuyuki Yamamoto; Naruo Yoshimura; Yasuo Ohashi; Masahiro Fukuoka
Phase I and pharmacologic study of BNP7787, a novel chemoprotector in patients with advanced non-small cell lung cancer.
Cancer chemotherapy and pharmacology 2011;67(3):533-42.
2011: FREDERICK HAUSHEER; A R Parker; Pavankumar N Petluru; K W Jair; S Chen; Q Huang; X Chen; P Y Ayala; D Shanmugarajah; H Kochat
Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of human aminopeptidase N.
Cancer chemotherapy and pharmacology 2011;67(2):381-91.
2010: Aulma R Parker; Pavankumar N Petluru; Meizhen Wu; Min Zhao; Harry Kochat; FREDERICK HAUSHEER
BNP7787-mediated modulation of paclitaxel- and cisplatin-induced aberrant microtubule protein polymerization in vitro.
Molecular cancer therapeutics 2010;9(9):2558-67.
2010: FREDERICK HAUSHEER; Dakshine Shanmugarajah; Betsy D Leverett; Xinghai Chen; Quili Huang; Harry Kochat; Pavankumar N Petluru; Aulma R Parker
Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of gamma-glutamyl transpeptidase.
Cancer chemotherapy and pharmacology 2010;65(5):941-51.
2010: Charles S Cleeland; John T Farrar; FREDERICK HAUSHEER
Assessment of cancer-related neuropathy and neuropathic pain.
The oncologist 2010;15 Suppl 2():13-8.
2010: Mark J Lema; Kathleen M Foley; FREDERICK HAUSHEER
Types and epidemiology of cancer-related neuropathic pain: the intersection of cancer pain and neuropathic pain.
The oncologist 2010;15 Suppl 2():3-8.
2010: FREDERICK HAUSHEER; Kathleen M Foley
Cancer neuropathic pain: overview of current status and future objectives.
The oncologist 2010;15 Suppl 2():1-2.
2009: Kojiro Shimozuma; Yasuo Ohashi; Ayano Takeuchi; Toshihiko Aranishi; Satoshi Morita; Katsumasa Kuroi; Shozo Ohsumi; Haruhiko Makino; Hirohumi Mukai; Noriyuki Katsumata; Yoshihide Sunada; Toru Watanabe; FREDERICK HAUSHEER
Feasibility and validity of the Patient Neurotoxicity Questionnaire during taxane chemotherapy in a phase III randomized trial in patients with breast cancer: N-SAS BC 02.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2009;17(12):1483-91.
2009: Katsumasa Kuroi; Norikazu Masuda; Satoshi Morita; Yasuo Ohashi; Shozo Ohsumi; Kojiro Shimozuma; Ayano Takeuchi; Toshihiko Aranishi; Kazufumi Hisamatsu; FREDERICK HAUSHEER
Prospective assessment of chemotherapy-induced peripheral neuropathy due to weekly paclitaxel in patients with advanced or metastatic breast cancer (CSP-HOR 02 study).
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2009;17(8):1071-80.
2009: Adil Daud; Jana Lynn Dawson; Ronald C DeConti; Elona Bicaku; Douglas C Marchion; Sem Bastien; FREDERICK HAUSHEER; Richard M Lush; Anthony Neuger; Daniel M Sullivan; Pamela N Munster
Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2479-87.
2009: Dakshine Shanmugarajah; Daoyuan Ding; Quili Huang; Xinghai Chen; Harry Kochat; Pavankumar N Petluru; Philippe Y Ayala; Aulma R Parker; FREDERICK HAUSHEER
Analysis of BNP7787 thiol-disulfide exchange reactions in phosphate buffer and human plasma using microscale electrochemical high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(10):857-66.
2008: Katsumasa Kuroi; Kojiro Shimozuma; Yasuo Ohashi; Ayano Takeuchi; Toshihiko Aranishi; Satoshi Morita; Shozo Ohsumi; Toru Watanabe; Stacey Bain; FREDERICK HAUSHEER
A questionnaire survey of physicians' perspectives regarding the assessment of chemotherapy-induced peripheral neuropathy in patients with breast cancer.
Japanese journal of clinical oncology 2008;38(11):748-54.
2008: Stuart A Grossman; Kathryn Carson; Surasak Phuphanich; Tracy T Batchelor; David Peereboom; L Burt Nabors; Glenn Lesser; FREDERICK HAUSHEER; Jeffrey G Supko
Phase I and pharmacokinetic study of karenitecin in patients with recurrent malignant gliomas.
Neuro-oncology 2008;10(4):608-16.
2007: Grant R Krow; Qiuli Huang; Steven W Szczepanski; FREDERICK HAUSHEER; Patrick J Carroll
Stereoselectivity in Diels-Alder reactions of diene-substituted N-alkoxycarbonyl-1,2-dihydropyridines.
The Journal of organic chemistry 2007;72(9):3458-66.
2006: FREDERICK HAUSHEER; Richard L Schilsky; Stacey Bain; Elmer J Berghorn; Frank Lieberman
Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy.
Seminars in oncology 2006;33(1):15-49.
2005: Adil Daud; Nikola Valkov; Barbara Centeno; Jennifer Derderian; Patricia Sullivan; Pamela N Munster; Patricia Urbas; Ronald C DeConti; Elmer Berghorn; Zhenmei Liu; FREDERICK HAUSHEER; Daniel Sullivan
Phase II trial of karenitecin in patients with malignant melanoma: clinical and translational study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(8):3009-16.
2004: Miranda Verschraagen; Epie Boven; Emine Torun; FREDERICK HAUSHEER; Aalt Bast; Wim J F van der Vijgh
Possible (enzymatic) routes and biological sites for metabolic reduction of BNP7787, a new protector against cisplatin-induced side-effects.
Biochemical pharmacology 2004;68(3):493-502.
2004: Patrick A Thompson; Stacey L Berg; Alexander Aleksic; Jody Z Kerr; Leticia McGuffey; Robert Dauser; Jed Nuchtern; FREDERICK HAUSHEER; Susan M Blaney
Plasma and cerebrospinal fluid pharmacokinetic study of BNP1350 in nonhuman primates.
Cancer chemotherapy and pharmacology 2004;53(6):527-32.
2004: Mary Johansen; Thomas Zukowski; Paulo M Hoff; Robert A Newman; Dan Ni; Toni Hutto; James Abbruzzeese; Elmer Berghorn; FREDERICK HAUSHEER; Timothy Madden
Final results of a phase I and pharmacokinetic study of gamma-methylene-10-deazaaminopterin (MDAM) administered intravenously daily for five consecutive days in patients with solid tumors.
Cancer chemotherapy and pharmacology 2004;53(5):370-6.
2004: Miranda Verschraagen; Epie Boven; Emine Torun; C A M Erkelens; FREDERICK HAUSHEER; Wim J F van der Vijgh
Pharmacokinetic behaviour of the chemoprotectants BNP7787 and mesna after an i.v. bolus injection in rats.
British journal of cancer 2004;90(8):1654-9.
2003: Judith A Smith; Robert A Newman; FREDERICK HAUSHEER; Timothy Madden
Evaluation of in vitro drug interactions with karenitecin, a novel, highly lipophilic camptothecin derivative in phase II clinical development.
Journal of clinical pharmacology 2003;43(9):1008-14.
2003: Miranda Verschraagen; Epie Boven; Rita Ruijter; Kasper van der Born; Johannes Berkhof; FREDERICK HAUSHEER; Wim J F van der Vijgh
Pharmacokinetics and preliminary clinical data of the novel chemoprotectant BNP7787 and cisplatin and their metabolites.
Clinical pharmacology and therapeutics 2003;74(2):157-69.
2003: FREDERICK HAUSHEER; Harry Kochat; Aulma R Parker; Daoyuan Ding; Shije Yao; Susan E Hamilton; Pavankumar N Petluru; Betsy D Leverett; Stacey H Bain; Jeffrey D Saxe
New approaches to drug discovery and development: a mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent.
Cancer chemotherapy and pharmacology 2003;52 Suppl 1():S3-15.
2003: Miranda Verschraagen; Epie Boven; Ivon Zegers; FREDERICK HAUSHEER; Wim J F van der Vijgh
Pharmacokinetics of BNP7787 and its metabolite mesna in plasma and ascites: a case report.
Cancer chemotherapy and pharmacology 2003;51(6):525-9.
2003: Miranda Verschraagen; Marc A Kedde; FREDERICK HAUSHEER; Wim J F van der Vijgh
The chemical reactivity of BNP7787 and its metabolite mesna with the cytostatic agent cisplatin: comparison with the nucleophiles thiosulfate, DDTC, glutathione and its disulfide GSSG.
Cancer chemotherapy and pharmacology 2003;51(6):499-504.
2003: Lakshmi Pendyala; Gary Schwartz; Patrick Smith; Joseph Zdanowicz; Michael Murphy; FREDERICK HAUSHEER
Modulation of plasma thiols and mixed disulfides by BNP7787 in patients receiving paclitaxel/cisplatin therapy.
Cancer chemotherapy and pharmacology 2003;51(5):376-84.
2002: Annemarie H Van Hattum; Hennie M M Schlüper; FREDERICK HAUSHEER; HERBERT PINEDO; Epie Boven
Novel camptothecin derivative BNP1350 in experimental human ovarian cancer: determination of efficacy and possible mechanisms of resistance.
International journal of cancer. Journal international du cancer 2002;100(1):22-9.
2002: Epie Boven; Miranda Verschraagen; Theresia M Hulscher; C A M Erkelens; FREDERICK HAUSHEER; HERBERT PINEDO; Wim J F van der Vijgh
BNP7787, a novel protector against platinum-related toxicities, does not affect the efficacy of cisplatin or carboplatin in human tumour xenografts.
European journal of cancer (Oxford, England : 1990) 2002;38(8):1148-56.
2001: J A Smith; FREDERICK HAUSHEER; Robert A Newman; Timothy L Madden
Development of a high-performance liquid chromatographic method to determine the concentration of karenitecin, a novel highly lipophilic camptothecin derivative, in human plasma and urine.
Journal of chromatography. B, Biomedical sciences and applications 2001;759(1):117-24.
2001: Stephen T Keir; FREDERICK HAUSHEER; AA Lawless; Darell D Bigner; Henry S Friedman
Therapeutic activity of 7-[(2-trimethylsilyl)ethyl)]-20 (S)-camptothecin against central nervous system tumor-derived xenografts in athymic mice.
Cancer chemotherapy and pharmacology 2001;48(1):83-7.
2001: Marc Maliepaard; Margôt van Gastelen; A Tohgo; FREDERICK HAUSHEER; Robert C A M van Waardenburg; Laurina A de Jong; Dick Pluim; Jos H Beijnen; J H M Schellens
Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):935-41.
2000: Asish Chaudhuri; P Seetharamalu; Patricia M Schwarz; FREDERICK HAUSHEER; Richard Luduena
The interaction of the B-ring of colchicine with alpha-tubulin: a novel footprinting approach.
Journal of molecular biology 2000;303(5):679-92.
2000: Annemarie H Van Hattum; HERBERT PINEDO; Hennie M M Schlüper; FREDERICK HAUSHEER; Epie Boven
New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer.
International journal of cancer. Journal international du cancer 2000;88(2):260-6.
1999: S Matsui; W Endo; Carol Wrzosek; K Haridas; P Seetharamulu; FREDERICK HAUSHEER; Youcef M Rustum
Characterisation of a synergistic interaction between a thymidylate synthase inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor karenitecin, BNP1100: mechanisms and clinical implications.
European journal of cancer (Oxford, England : 1990) 1999;35(6):984-93.
1998: FREDERICK HAUSHEER; P Kanter; S Cao; K Haridas; P Seetharamulu; D Reddy; Pavankumar N Petluru; Ming Zhao; D Murali; J D Saxe; Shije Yao; N Martinez; A Zukowski; Youcef M Rustum
Modulation of platinum-induced toxicities and therapeutic index: mechanistic insights and first- and second-generation protecting agents.
Seminars in oncology 1998;25(5):584-99.
1998: Shije Yao; D Murali; P Seetharamulu; K Haridas; Pavankumar N Petluru; D G Reddy; FREDERICK HAUSHEER
Topotecan lactone selectively binds to double- and single-stranded DNA in the absence of topoisomerase I.
Cancer research 1998;58(17):3782-6.
1998: E M Shulman-Roskes; D A Noe; Michael P Gamcsik; A L Marlow; John Hilton; FREDERICK HAUSHEER; O Michael Colvin; Susan M Ludeman
The partitioning of phosphoramide mustard and its aziridinium ions among alkylation and P-N bond hydrolysis reactions.
Journal of medicinal chemistry 1998;41(4):515-29.
1997: H Su; T L Chen; FREDERICK HAUSHEER; eric rowinsky
Novel high-performance liquid chromatographic assay using fluorescence detection for the quantitation of plasma gamma-methylene-10-deazaaminopterin and its major metabolite, 7-hydroxy-gamma-methylene-10-deazaaminopterin, in patients with solid cancers in a phase I trial.
Journal of chromatography. B, Biomedical sciences and applications 1997;695(2):401-8.
1996: FREDERICK HAUSHEER; N D Jones; P Seetharamulu; U C Singh; J B Deeter; L W Hertel; Julian S Kroin
Ab initio quantum mechanical and X-ray crystallographic studies of gemcitabine and 2'-deoxy cytosine.
Computers & chemistry 1996;20(4):459-67.
1996: S Cao; A Abraham; M G Nair; R Pati; J H Galivan; FREDERICK HAUSHEER; Youcef M Rustum
Polyglutamylation of the dihydrofolate reductase inhibitor gamma-methylene-10-deazaaminopterin is not essential for antitumor activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(4):707-12.
1993: R R Monaco; FREDERICK HAUSHEER
Binding site for ethidium cation in the major groove of B-form DNA.
Journal of biomolecular structure & dynamics 1993;10(4):675-80.
1990: FREDERICK HAUSHEER; U C Singh; J D Saxe; O Michael Colvin; P O T'su
Can oligonucleoside methylphosphonates form a stable triplet with a double DNA helix?
Anti-cancer drug design 1990;5(2):159-67.
1989: FREDERICK HAUSHEER; U C Singh; J D Saxe; O Michael Colvin
Identification of local determinants of DNA interstrand crosslink formation by cyclophosphamide metabolites.
Anti-cancer drug design 1989;4(4):281-94.
1989: T C Palmer; FREDERICK HAUSHEER; J D Saxe
Applications of ray tracing in molecular graphics.
Journal of molecular graphics 1989;7(3):160-4, 157-8.
1989: FREDERICK HAUSHEER; S N Rao; Michael P Gamcsik; P A Kollman; O Michael Colvin; J D Saxe; Barry D Nelkin; I J McLennan; G Barnett; Stephen B Baylin
Computational analysis of structural and energetic consequences of DNA methylation.
Carcinogenesis 1989;10(6):1131-7.
1987: FREDERICK HAUSHEER; R A Josephson; Louise B. Grochow; D Weissman; Jeffrey A Brinker; H F Weisman
Intracardiac sarcoma diagnosed by left ventricular endomyocardial biopsy.
Chest 1987;92(1):177-9.
1987: K M Kumor; Louise B. Grochow; FREDERICK HAUSHEER
Unusual opioid withdrawal syndrome. A case-report.
Lancet 1987;1(8535):720-1.
1987: FREDERICK HAUSHEER; J W Yarbro
Diagnosis and treatment of malignant pleural effusion.
Cancer metastasis reviews 1987;6(1):23-40.
1986: FREDERICK HAUSHEER; J W Yarbro
Reexpansion pulmonary edema.
Missouri medicine 1986;83(1):33-5.
1985: FREDERICK HAUSHEER; J W Yarbro
Diagnosis and treatment of malignant pleural effusion.
Seminars in oncology 1985;12(1):54-75.
1983: FREDERICK HAUSHEER; J W Yarbro
Malignant effusions as oncologic emergencies.
Progress in clinical and biological research 1983;132D():347-60.