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Ian Tickle

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Philip J Day; Anne Cleasby; Ian Tickle; Marc O'Reilly; Joe E Coyle; Finn P Holding; Rachel L McMenamin; Jeff Yon; Rajiv Chopra; Christoph Lengauer; Harren Jhoti
Crystal structure of human CDK4 in complex with a D-type cyclin.
Ian Tickle
Experimental determination of optimal root-mean-square deviations of macromolecular bond lengths and angles from their restrained ideal values.
Philip Day; Andrew Sharff; Lina Parra; Anne Cleasby; Mark Williams; Stefan Hörer; Herbert Nar; Norbert Redemann; Ian Tickle; Jeff Yon
Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

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All Publications

2009: Philip J Day; Anne Cleasby; Ian Tickle; Marc O'Reilly; Joe E Coyle; Finn P Holding; Rachel L McMenamin; Jeff Yon; Rajiv Chopra; Christoph Lengauer; Harren Jhoti
Crystal structure of human CDK4 in complex with a D-type cyclin.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4166-70.
2007: Ian Tickle
Experimental determination of optimal root-mean-square deviations of macromolecular bond lengths and angles from their restrained ideal values.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 12):1274-81; author reply 1282-3.
2007: Philip Day; Andrew Sharff; Lina Parra; Anne Cleasby; Mark Williams; Stefan Hörer; Herbert Nar; Norbert Redemann; Ian Tickle; Jeff Yon
Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 5):587-96.
2006: Wijnand T M Mooij; Michael J Hartshorn; Ian Tickle; Andrew Sharff; Marcel L Verdonk; Harren Jhoti
Automated protein-ligand crystallography for structure-based drug design.
ChemMedChem 2006;1(8):827-38.
2005: Michael J Hartshorn; Christopher W Murray; Anne Cleasby; Martyn Frederickson; Ian Tickle; Harren Jhoti
Fragment-based lead discovery using X-ray crystallography.
Journal of medicinal chemistry 2005;48(2):403-13.
2004: Ian Tickle; Andrew Sharff; Mladen Vinkovic; Jeff Yon; Harren Jhoti
High-throughput protein crystallography and drug discovery.
Chemical Society reviews 2004;33(8):558-65.
2004: Pamela A Williams; Jose Cosme; Dijana Matak Vinkovic; Alison Ward; Hayley C Angove; Philip J Day; Clemens Vonrhein; Ian Tickle; Harren Jhoti
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.
Science (New York, N.Y.) 2004;305(5684):683-6.
2003: Andrey A Lebedev; Ian Tickle; Roman A Laskowski; David S Moss
Estimation of weights and validation: a marginal likelihood approach.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 9):1557-66.
2002: Louise Birch; Christopher W Murray; Michael J Hartshorn; Ian Tickle; Marcel L Verdonk
Sensitivity of molecular docking to induced fit effects in influenza virus neuraminidase.
Journal of computer-aided molecular design 2002;16(12):855-69.
2002: D Thompson; MB Pepys; Ian Tickle; S Wood
The structures of crystalline complexes of human serum amyloid P component with its carbohydrate ligand, the cyclic pyruvate acetal of galactose.
Journal of molecular biology 2002;320(5):1081-6.
2002: Karen A Bunting; Jonathan B Cooper; Ian Tickle; Douglas B Young
Engineering of an intersubunit disulfide bridge in the iron-superoxide dismutase of Mycobacterium tuberculosis.
Archives of biochemistry and biophysics 2002;397(1):69-76.
2000: Ian Tickle; Roman A Laskowski; David S Moss
Rfree and the rfree ratio. II. Calculation Of the expected values and variances of cross-validation statistics in macromolecular least-squares refinement.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 4):442-50.
2000: Peter T Erskine; E M Duke; Ian Tickle; NM Senior; Martin J Warren; Jonathan B Cooper
MAD analyses of yeast 5-aminolaevulinate dehydratase: their use in structure determination and in defining the metal-binding sites.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 4):421-30.
1999: Robert J C Gilbert; José L Jiménez; S Chen; Ian Tickle; Jamie Rossjohn; M Parker; Peter W Andrew; Helen R Saibil
Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae.
Cell 1999;97(5):647-55.
1998: Ian Tickle; Roman A Laskowski; David S Moss
Rfree and the rfree ratio. I. Derivation of expected values of cross-validation residuals used in macromolecular least-squares refinement.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 4):547-57.
1998: Ian Tickle; Roman A Laskowski; David S Moss
Error estimates of protein structure coordinates and deviations from standard geometry by full-matrix refinement of gammaB- and betaB2-crystallin.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 2):243-52.
1998: K Bunting; Jonathan B Cooper; Mohammed O Badasso; Ian Tickle; M Newton; Steve P Wood; Y Zhang; D Young
Engineering a change in metal-ion specificity of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis-- X-ray structure analysis of site-directed mutants.
European journal of biochemistry / FEBS 1998;251(3):795-803.
1997: Peter T Erskine; NM Senior; SJ Awan; R Lambert; G Lewis; Ian Tickle; Muhammad Sarwar; P Spencer; P Thomas; Martin J Warren; Peter M Shoolingin-Jordan; Steve P Wood; Jonathan B Cooper
X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase.
Nature structural biology 1997;4(12):1025-31.
1997: Peter T Erskine; NM Senior; S Maignan; J Cooper; R Lambert; G Lewis; P Spencer; SJ Awan; M Warren; Ian Tickle; P Thomas; Steve P Wood; Peter M Shoolingin-Jordan
Crystallization of 5-aminolaevulinic acid dehydratase from Escherichia coli and Saccharomyces cerevisiae and preliminary X-ray characterization of the crystals.
Protein science : a publication of the Protein Society 1997;6(8):1774-6.
1996: Ian Tickle; H P Driessen
Molecular replacement using known structural information.
Methods in molecular biology (Clifton, N.J.) 1996;56():173-203.
1994: J Husain; Ian Tickle; Steve P Wood
Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia.
FEBS letters 1994;342(2):154-8.
1994: C G Dealwis; C Frazao; Mohammed O Badasso; Jonathan B Cooper; Ian Tickle; H Driessen; Tom L Blundell; K Murakami; H Miyazaki; J Sueiras-Diaz
X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
Journal of molecular biology 1994;236(1):342-60.
1994: jonas emsley; Helen E White; B P O'Hara; G Oliva; N Srinivasan; Ian Tickle; Tom L Blundell; M B Pepys; Steve P Wood
Structure of pentameric human serum amyloid P component.
Nature 1994;367(6461):338-45.
1993: M Newman; F Watson; P Roychowdhury; H Jones; Mohammed O Badasso; Anne Cleasby; Steve P Wood; Ian Tickle; Tom L Blundell
X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 A resolution of the aspartic proteinase from Mucor pusillus.
Journal of molecular biology 1993;230(1):260-83.
1993: C F Aguilar; M P Newman; J Sanz Aparicio; Jonathan B Cooper; Ian Tickle; Tom L Blundell
The use of protein homologues in the rotation function.
Acta crystallographica. Section A, Foundations of crystallography 1993;49 ( Pt 2)():306-15.
1992: Venugopal Dhanaraj; C G Dealwis; C Frazao; Mohammed O Badasso; Bancinyane L Sibanda; Ian Tickle; Jonathan B Cooper; H P Driessen; M Newman; C Aguilar
X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.
Nature 1992;357(6378):466-72.
1991: H P Driessen; B Bax; Christine Slingsby; P F Lindley; D Mahadevan; David S Moss; Ian Tickle
Structure of oligomeric beta B2-crystallin: an application of the T2 translation function to an asymmetric unit containing two dimers.
Acta crystallographica. Section B, Structural science 1991;47 ( Pt 6)():987-97.
1991: M Newman; M Safro; C Frazao; G Khan; A Zdanov; Ian Tickle; Tom L Blundell; N Andreeva
X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 A resolution of bovine chymosin.
Journal of molecular biology 1991;221(4):1295-309.
1991: D W Wang; H P Driessen; Ian Tickle
MOLPACK: molecular graphics for studying the packing of protein molecules in the crystallographic unit cell.
Journal of molecular graphics 1991;9(1):50-2, 38.
1990: G D Webster; Mark R Sanderson; J V Skelly; Stephen Neidle; P F Swann; B F Li; Ian Tickle
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6693-7.
1990: Jonathan B Cooper; G Khan; G Taylor; Ian Tickle; Tom L Blundell
X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution.
Journal of molecular biology 1990;214(1):199-222.
1990: J Husain; Tom L Blundell; S Cooper; JE Pitts; Ian Tickle; Steve P Wood; V J Hruby; Angeliki Buku; A J Fischman; H R Wyssbrod
The conformation of deamino-oxytocin: X-ray analysis of the 'dry' and 'wet' forms.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1243):625-54.
1990: Tom L Blundell; J A Jenkins; B T Sewell; Laurence H Pearl; Jonathan B Cooper; Ian Tickle; B Veerapandian; Steve P Wood
X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin.
Journal of molecular biology 1990;211(4):919-41.
1986: Steve P Wood; Ian Tickle; A M Treharne; JE Pitts; Y Mascarenhas; J Y Li; J Husain; S Cooper; Tom L Blundell; V J Hruby
Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Science (New York, N.Y.) 1986;232(4750):633-6.
1986: J F Griffin; D A Langs; G D Smith; T L Blundell; Ian Tickle; S Bedarkar
The crystal structures of [Met5]enkephalin and a third form of [Leu5]enkephalin: observations of a novel pleated beta-sheet.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(10):3272-6.
1985: G M Clore; A M Gronenborn; David S Moss; Ian Tickle
Refinement of the solution structure of the B DNA hexamer 5'd(C-G-T-A-C-G)2 on the basis of inter-proton distance data.
Journal of molecular biology 1985;185(1):219-26.
1985: I D Glover; David S Moss; Ian Tickle; JE Pitts; I Haneef; Steve P Wood; T L Blundell
Anisotropic thermal motion and polypeptide secondary structure studied by X-ray analysis at 0.98A resolution.
Advances in biophysics 1985;20():1-12.
1984: I D Glover; D J Barlow; JE Pitts; Steve P Wood; Ian Tickle; T L Blundell; K Tatemoto; J R Kimmel; Axel Wollmer; W Strassburger
Conformational studies on the pancreatic polypeptide hormone family.
European journal of biochemistry / FEBS 1984;142(2):379-85.
1983: S A Chawdhury; E J Dodson; G G Dodson; C D Reynolds; S P Tolley; T L Blundell; Anne Cleasby; JE Pitts; Ian Tickle; S P Wood
The crystal structures of three non-pancreatic human insulins.
Diabetologia 1983;25(6):460-4.
1983: W Strassburger; Axel Wollmer; JE Pitts; I D Glover; Ian Tickle; T L Blundell; G J Steffens; W A Günzler; F Otting; Leopold Flohé
Adaptation of plasminogen activator sequences to known protease structures.
FEBS letters 1983;157(2):219-23.
1983: I Glover; I Haneef; J Pitts; S Wood; D Moss; Ian Tickle; T Blundell
Conformational flexibility in a small globular hormone: x-ray analysis of avian pancreatic polypeptide at 0.98-A resolution.
Biopolymers 1983;22(1):293-304.
1982: W Strassburger; U Glatter; Axel Wollmer; Jörg Fleischhauer; D A Mercola; T L Blundell; I Glover; JE Pitts; Ian Tickle; Steve P Wood
Calculated tyrosyl circular dichroism of proteins: absence of tryptophan and cystine interferences in avian pancreatic polypeptide.
FEBS letters 1982;139(2):295-9.
1981: Tom L Blundell; JE Pitts; Ian Tickle; Steve P Wood; C W Wu
X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4175-9.
1981: Tom L Blundell; P Lindley; L Miller; D Moss; Christine Slingsby; Ian Tickle; B Turnell; G Wistow
The molecular structure and stability of the eye lens: x-ray analysis of gamma-crystallin II.
Nature 1981;289(5800):771-7.
1981: T L Blundell; JE Pitts; Ian Tickle; Steve P Wood
The conformation and receptor binding of pancreatic hormones.
Biochemical Society transactions 1981;9(1):31-2.
1980: JE Pitts; Steve P Wood; L Hearn; Ian Tickle; C W Wu; T L Blundell; I C Robinson
Crystallisation and preliminary crystallographic data of a porcine neurophysin I-Tyr-Phe-NH2 complex.
FEBS letters 1980;121(1):41-3.
1979: T L Blundell; L Hearn; Ian Tickle; R A Palmer; B A Morgan; G D Smith; J F Griffin
Crystal structure of [Leu5]enkephalin.
Science (New York, N.Y.) 1979;205(4402):220.
1978: S P Wood; Ian Tickle; T L Blundell; A Wollmer; D F Steiner
Insulin polymorphism: some physical and biological properties of rat insulins.
Archives of biochemistry and biophysics 1978;186(1):175-83.
1977: S P Wood; J E Pitts; T L Blundell; Ian Tickle; J A Jenkins
Purification, crystallisation and preliminary X-ray studies on avian pancreatic polypeptide.
European journal of biochemistry / FEBS 1977;78(1):119-26.
1977: E Subramanian; I D Swan; M Liu; David Davies; J A Jenkins; Ian Tickle; T L Blundell
Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(2):556-9.
1977: J A Jenkins; Ian Tickle; T Sewell; T L Blundell
The structure at 0.3nm (3A) resolution of the acid proteinase from Endothia parasitica [proceedings].
Biochemical Society transactions 1977;5(4):1120-1.
1977: J E Pitts; J A Jenkins; Ian Tickle; T L Blundell; S P Wood
Structural studies on avian pancreatic polypeptide [proceedings].
Biochemical Society transactions 1977;5(4):1119-20.
1977: S Bedarkar; T L Blundell; S Dockerill; Ian Tickle; S P Wood
Polypeptide hormone-receptor interactions: the structure and receptor binding of insulin and glucagon.
Ciba Foundation symposium 1977;(60):105-21.
1977: S Dockerill; T L Blundell; K Sasaki; Ian Tickle; S P Wood
The relation of structure to storage and receptor binding of glucagon [proceedings].
Biochemical Society transactions 1977;5(4):1121-2.
1976: T L Blundell; S Dockerill; K Sasaki; Ian Tickle; S P Wood
The relation of structure to storage and receptor binding of glucagon.
Metabolism: clinical and experimental 1976;25(11 Suppl 1):1331-6.
1976: R A Pullen; D G Lindsay; S P Wood; Ian Tickle; T L Blundell; A Wollmer; G Krail; D Brandenburg; H Zahn; J Gliemann; S Gammeltoft
Receptor-binding region of insulin.
Nature 1976;259(5542):369-73.
1975: J A Jenkins; T L Blundell; Ian Tickle; L Ungaretti
The low resolution structure analysis of an acid proteinase from Endothia parasitica.
Journal of molecular biology 1975;99(4):583-90.
1975: K Sasaki; S Dockerill; D A Adamiak; Ian Tickle; T Blundell
X-ray analysis of glucagon and its relationship to receptor binding.
Nature 1975;257(5529):751-7.
1975: R A Pullen; J A Jenkins; Ian Tickle; S P Wood; T L Blundell
The relation of polypeptide hormone structure and flexibility to receptor binding: the relevance of X-ray studies on insulins, glucagon and human placental lactogen.
Molecular and cellular biochemistry 1975;8(1):5-20.