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Silvio Gutkind

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
45
Patel, Vyomesh
22
Molinolo, Alfredo
21
Teramoto, Hidemi
17
Saavedra, Juan
16
Marinissen, Maria Julia
14
Amornphimoltham, Panomwat
13
Crespo, Piero
13
Montaner, Silvia
12
Ensley, John
12
Sodhi, Akrit
11
Gavard, Julie
10
Castellone, Maria Domenica
10
Chiariello, Mario
9
Igishi, Tadashi
8
Fukuhara, Shigetomo

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Publications

TOP 3
El-Naggar Adel K; Kaye Frederic J; Shirazi Yasaman; Gutkind J Silvio; Forastiere Arlene A
Meeting report--the NIDCR 2(nd) Salivary Gland Tumor Meeting, November 2008.
Chikkaveeraiah Bhaskara V; Bhirde Ashwin; Malhotra Ruchika; Patel Vyomesh; Gutkind J Silvio; Rusling James F
Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer.
Bhirde Ashwin A; Sousa Alioscka A; Patel Vyomesh; Azari Afrouz A; Gutkind J Silvio; Leapman Richard D; Rusling James F
Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes.

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All Publications

2009: El-Naggar Adel K; Kaye Frederic J; Shirazi Yasaman; Gutkind J Silvio; Forastiere Arlene A
Meeting report--the NIDCR 2(nd) Salivary Gland Tumor Meeting, November 2008.
Head & neck 2009;31(12):1542-3.
2009: Chikkaveeraiah Bhaskara V; Bhirde Ashwin; Malhotra Ruchika; Patel Vyomesh; Gutkind J Silvio; Rusling James F
Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer.
Analytical chemistry 2009;81(21):9129-34.
2009: Bhirde Ashwin A; Sousa Alioscka A; Patel Vyomesh; Azari Afrouz A; Gutkind J Silvio; Leapman Richard D; Rusling James F
Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes.
Nanomedicine (London, England) 2009;4(7):763-72.
2009: Castilho Rogerio M; Squarize Cristiane H; Chodosh Lewis A; Williams Bart O; Gutkind J Silvio
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.
Cell stem cell 2009;5(3):279-89.
2009: Bian Yansong; Terse Anita; Du Juan; Hall Bradford; Molinolo Alfredo; Zhang Pin; Chen Wanjun; Flanders Kathleen C; Gutkind J Silvio; Wakefield Lalage M; Kulkarni Ashok B
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.
Cancer research 2009;69(14):5918-26.
2009: Guzmán-Hernández María Luisa; Vázquez-Macías Aleida; Carretero-Ortega Jorge; Hernández-García Ricardo; García-Regalado Alejandro; Hernández-Negrete Ivette; Reyes-Cruz Guadalupe; Gutkind J Silvio; Vázquez-Prado José
Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis.
The Journal of biological chemistry 2009;284(27):18334-46.
2009: Raimondi Ana R; Molinolo Alfredo; Gutkind J Silvio
Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model.
Cancer research 2009;69(10):4159-66.
2009: Vitale-Cross Lynn; Czerninski Rakefet; Amornphimoltham Panomwat; Patel Vyomesh; Molinolo Alfredo A; Gutkind J Silvio
Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer.
Cancer prevention research (Philadelphia, Pa.) 2009;2(5):419-22.
2009: Turjanski Adrian Gustavo; Hummer Gerhard; Gutkind J Silvio
How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study.
Journal of the American Chemical Society 2009;131(17):6141-8.
2009: Gavard Julie; Hou Xu; Qu Yi; Masedunskas Andrius; Martin Daniel; Weigert Roberto; Li Xuri; Gutkind J Silvio
A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability.
Molecular and cellular biology 2009;29(9):2469-80.
2009: Molinolo Alfredo A; Amornphimoltham Panomwat; Squarize Cristiane H; Castilho Rogerio M; Patel Vyomesh; Gutkind J Silvio
Dysregulated molecular networks in head and neck carcinogenesis.
Oral oncology 2009;45(4-5):324-34.
2009: Castellone Maria Domenica; De Falco Valentina; Rao Deva Magendra; Bellelli Roberto; Muthu Magesh; Basolo Fulvio; Fusco Alfredo; Gutkind J Silvio; Santoro Massimo
The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.
Cancer research 2009;69(5):1867-76.
2009: Mani Vigneshwaran; Chikkaveeraiah Bhaskara V; Patel Vyomesh; Gutkind J Silvio; Rusling James F
Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification.
ACS nano 2009;3(3):585-94.
2009: Martin Daniel; Galisteo Rebeca; Gutkind J Silvio
CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex.
The Journal of biological chemistry 2009;284(10):6038-42.
2009: Bhirde Ashwin A; Patel Vyomesh; Gavard Julie; Zhang Guofeng; Sousa Alioscka A; Masedunskas Andrius; Leapman Richard D; Weigert Roberto; Gutkind J Silvio; Rusling James F
Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery.
ACS nano 2009;3(2):307-16.
2009: Gutkind J Silvio; Offermanns Stefan
A new G(q)-initiated MAPK signaling pathway in the heart.
Developmental cell 2009;16(2):163-4.
2009: Sako Keisuke; Fukuhara Shigetomo; Minami Takashi; Hamakubo Takao; Song Haihua; Kodama Tatsuhiko; Fukamizu Akiyoshi; Gutkind J Silvio; Koh Gou Young; Mochizuki Naoki
Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2.
The Journal of biological chemistry 2009;284(9):5592-601.
2009: Czerninski Rakefet; Amornphimoltham Panomwat; Patel Vyomesh; Molinolo Alfredo A; Gutkind J Silvio
Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model.
Cancer prevention research (Philadelphia, Pa.) 2009;2(1):27-36.
2009: Wang Huixin; Patel Vyomesh; Miyazaki Hiroshi; Gutkind J Silvio; Yeudall W Andrew
Role for EPS8 in squamous carcinogenesis.
Carcinogenesis 2009;30(1):165-74.
2009: Martin Daniel; Gutkind J Silvio
Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation.
Methods in enzymology 2009;460():125-50.
2008: Schneider Abraham; Younis Rania H; Gutkind J Silvio
Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma.
Neoplasia (New York, N.Y.) 2008;10(11):1295-302.
2008: Gavard Julie; Gutkind J Silvio
Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q.
The Journal of biological chemistry 2008;283(44):29888-96.
2008: Paccione Rachel J; Miyazaki Hiroshi; Patel Vyomesh; Waseem Ahmad; Gutkind J Silvio; Zehner Zendra E; Yeudall W Andrew
Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility.
Molecular cancer therapeutics 2008;7(9):2894-903.
2008: Squarize Cristiane H; Castilho Rogerio M; Gutkind J Silvio
Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin.
Cancer research 2008;68(17):7066-72.
2008: Sun C; Dobi A; Mohamed A; Li H; Thangapazham R L; Furusato B; Shaheduzzaman S; Tan S-H; Vaidyanathan G; Whitman E; Hawksworth D J; Chen Y; Nau M; Patel V; Vahey M; Gutkind J S; Sreenath T; Petrovics G; Sesterhenn I A; McLeod D G; Srivastava S
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.
Oncogene 2008;27(40):5348-53.
2008: Gavard Julie; Gutkind J Silvio
VE-cadherin and claudin-5: it takes two to tango.
Nature cell biology 2008;10(8):883-5.
2008: Sausville Justin; Molinolo Alfredo A; Cheng Xiangfei; Frampton Jon; Takebe Naoko; Gutkind J Silvio; Feldman Ricardo A
RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(12):3948-55.
2008: Lyons J Guy; Patel Vyomesh; Roue Naomi C; Fok Sandra Y; Soon Lilian L; Halliday Gary M; Gutkind J Silvio
Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes.
Cancer research 2008;68(12):4525-30.
2008: Tan Wenfu; Palmby Todd R; Gavard Julie; Amornphimoltham Panomwat; Zheng Yi; Gutkind J Silvio
An essential role for Rac1 in endothelial cell function and vascular development.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1829-38.
2008: Zhou G; Xie T-X; Zhao M; Jasser S A; Younes M N; Sano D; Lin J; Kupferman M E; Santillan A A; Patel V; Gutkind J S; Ei-Naggar A K; Emberley E D; Watson P H; Matsuzawa S-I; Reed J C; Myers J N
Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity.
Oncogene 2008;27(25):3527-38.
2008: Turjanski Adrian Gustavo; Gutkind J Silvio; Best Robert B; Hummer Gerhard
Binding-induced folding of a natively unstructured transcription factor.
PLoS computational biology 2008;4(4):e1000060.
2008: Gómez Román J Javier; Garay Gorka Ochoa; Saenz Pilar; Escuredo Kepa; Sanz Ibayondo Cristina; Gutkind Silvio; Junquera Corina; Simón Laureano; Martínez Antonio; Fernández Luna José Luis; Val-Bernal J Fernando
Plexin B1 is downregulated in renal cell carcinomas and modulates cell growth.
Translational research : the journal of laboratory and clinical medicine 2008;151(3):134-40.
2008: Martin D; Galisteo R; Ji Y; Montaner S; Gutkind J S
An NF-kappaB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia.
Oncogene 2008;27(13):1844-52.
2008: Patel Vyomesh; Hood Brian L; Molinolo Alfredo A; Lee Norman H; Conrads Thomas P; Braisted John C; Krizman David B; Veenstra Timothy D; Gutkind J Silvio
Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(4):1002-14.
2008: Amornphimoltham Panomwat; Patel Vyomesh; Leelahavanichkul Kantima; Abraham Robert T; Gutkind J Silvio
A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer.
Cancer research 2008;68(4):1144-53.
2008: Gavard Julie; Patel Vyomesh; Gutkind J Silvio
Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.
Developmental cell 2008;14(1):25-36.
2008: Wirth Angela; Benyó Zoltán; Lukasova Martina; Leutgeb Barbara; Wettschureck Nina; Gorbey Stefan; Orsy Petra; Horváth Béla; Maser-Gluth Christiane; Greiner Erich; Lemmer Björn; Schütz Günther; Gutkind J Silvio; Offermanns Stefan
G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension.
Nature medicine 2008;14(1):64-8.
2008: Wolf Joshua; Palmby Todd R; Gavard Julie; Williams Bart O; Gutkind J Silvio
Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6.
FEBS letters 2008;582(2):255-61.
2008: Liu Shihui; Wang Hailun; Currie Brooke M; Molinolo Alfredo; Leung Howard J; Moayeri Mahtab; Basile John R; Alfano Randall W; Gutkind J Silvio; Frankel Arthur E; Bugge Thomas H; Leppla Stephen H
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature.
The Journal of biological chemistry 2008;283(1):529-40.
2008: Yamaza Takayoshi; Miura Yasuo; Bi Yanming; Liu Yongzhong; Akiyama Kentaro; Sonoyama Wataru; Patel Voymesh; Gutkind Silvio; Young Marian; Gronthos Stan; Le Anh; Wang Cun-Yu; Chen WanJun; Shi Songtao
Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents.
PloS one 2008;3(7):e2615.
2007: Martín María José; Tanos Tamara; García Ana Belén; Martin Daniel; Gutkind J Silvio; Coso Omar A; Marinissen Maria Julia
The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis.
The Journal of biological chemistry 2007;282(47):34510-24.
2007: Basile John R; Gavard Julie; Gutkind J Silvio
Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility.
The Journal of biological chemistry 2007;282(48):34888-95.
2007: Molinolo Alfredo A; Hewitt Stephen M; Amornphimoltham Panomwat; Keelawat Somboon; Rangdaeng Samraeung; Meneses García Abelardo; Raimondi Ana R; Jufe Rafael; Itoiz María; Gao Yan; Saranath Dhananjaya; Kaleebi George S; Yoo George H; Leak Lee; Myers Ernest M; Shintani Satoru; Wong David; Massey H Davis; Yeudall W Andrew; Lonardo Fulvio; Ensley John; Gutkind J Silvio
Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(17):4964-73.
2007: Kesavapany Sashi; Patel Vyomesh; Zheng Ya-Li; Pareek Tej K; Bjelogrlic Mia; Albers Wayne; Amin Niranjana; Jaffe Howard; Gutkind J Silvio; Strong Michael J; Grant Philip; Pant Harish C
Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons.
Molecular biology of the cell 2007;18(9):3645-55.
2007: Wagenaar-Miller Rebecca A; Engelholm Lars H; Gavard Julie; Yamada Susan S; Gutkind J Silvio; Behrendt Niels; Bugge Thomas H; Holmbeck Kenn
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.
Molecular and cellular biology 2007;27(18):6309-22.
2007: Liu Hongjun; Fergusson Maria M; Castilho Rogerio M; Liu Jie; Cao Liu; Chen Jichun; Malide Daniela; Rovira Ilsa I; Schimel Daniel; Kuo Calvin J; Gutkind J Silvio; Hwang Paul M; Finkel Toren
Augmented Wnt signaling in a mammalian model of accelerated aging.
Science (New York, N.Y.) 2007;317(5839):803-6.
2007: Hernández-Negrete Ivette; Carretero-Ortega Jorge; Rosenfeldt Hans; Hernández-García Ricardo; Calderón-Salinas J Victor; Reyes-Cruz Guadalupe; Gutkind J Silvio; Vázquez-Prado José
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.
The Journal of biological chemistry 2007;282(32):23708-15.
2007: Castilho R M; Squarize C H; Patel V; Millar S E; Zheng Y; Molinolo A; Gutkind J S
Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells.
Oncogene 2007;26(35):5078-85.
2007: Honjo Yasuyuki; Bian Yansong; Kawakami Koji; Molinolo Alfredo; Longenecker Glenn; Boppana Ramanamurthy; Larsson Jonas; Karlsson Stefan; Gutkind J Silvio; Puri Raj K; Kulkarni Ashok B
TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma.
Cell cycle (Georgetown, Tex.) 2007;6(11):1360-6.
2007: Patel Vyomesh; Rosenfeldt Hans M; Lyons Ruth; Servitja Joan-Marc; Bustelo Xosé R; Siroff Mary; Gutkind J Silvio
Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.
Carcinogenesis 2007;28(6):1145-52.
2007: Turjanski A G; Vaqué J P; Gutkind J S
MAP kinases and the control of nuclear events.
Oncogene 2007;26(22):3240-53.
2007: Touge Hirokazu; Chikumi Hiroki; Igishi Tadashi; Kurai Jun; Makino Haruhiko; Tamura Yoshisato; Takata Miyako; Yoneda Kazuhiko; Nakamoto Masaki; Suyama Hisashi; Gutkind J Silvio; Shimizu Eiji
Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors.
International journal of oncology 2007;30(3):709-15.
2007: Basile John R; Holmbeck Kenn; Bugge Thomas H; Gutkind J Silvio
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.
The Journal of biological chemistry 2007;282(9):6899-905.
2007: Gavard Julie; Gutkind J Silvio
[VE-cadherin takes a walk on the wild side]
Médecine sciences : M/S 2007;23(2):119-21.
2007: Dorsam Robert T; Gutkind J Silvio
G-protein-coupled receptors and cancer.
Nature reviews. Cancer 2007;7(2):79-94.
2007: Montero Girard Guadalupe; Vanzulli Silvia I; Cerliani Juan Pablo; Bottino María Cecilia; Bolado Julieta; Vela Jorge; Becu-Villalobos Damasia; Benavides Fernando; Gutkind Silvio; Patel Vyomesh; Molinolo Alfredo; Lanari Claudia
Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment.
Breast cancer research : BCR 2007;9(2):R22.
2006: Castellone Maria Domenica; Teramoto Hidemi; Gutkind J Silvio
Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.
Cancer research 2006;66(23):11085-8.
2006: Tan Wenfu; Martin Daniel; Gutkind J Silvio
The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.
The Journal of biological chemistry 2006;281(51):39542-9.
2006: Gavard Julie; Gutkind J Silvio
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.
Nature cell biology 2006;8(11):1223-34.
2006: Squarize Cristiane H; Castilho Rogerio M; Sriuranpong Virote; Pinto Decio S; Gutkind Jorge Silvio
Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma.
Neoplasia (New York, N.Y.) 2006;8(9):733-46.
2006: Sanchez Verónica Muriel; Crespo Alejandro; Gutkind J Silvio; Turjanski Adrián Gustavo
Investigation of the catalytic mechanism of farnesyl pyrophosphate synthase by computer simulation.
The journal of physical chemistry. B 2006;110(36):18052-7.
2006: Yu Xin; Munge Bernard; Patel Vyomesh; Jensen Gary; Bhirde Ashwin; Gong Joseph D; Kim Sang N; Gillespie John; Gutkind J Silvio; Papadimitrakopoulos Fotios; Rusling James F
Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers.
Journal of the American Chemical Society 2006;128(34):11199-205.
2006: Sodhi Akrit; Chaisuparat Risa; Hu Jiadi; Ramsdell Amanda K; Manning Brendan D; Sausville Edward A; Sawai Earl T; Molinolo Alfredo; Gutkind J Silvio; Montaner Silvia
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.
Cancer cell 2006;10(2):133-43.
2006: Teramoto H; Miwa H; Patel V; Letwin N; Castellone M D; Imai N; Shikami M; Imamura A; Gutkind J S; Nitta M; Lee N H
Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray.
Clinical and laboratory haematology 2006;28(4):262-6.
2006: Basile John R; Castilho Rogerio M; Williams Vanessa P; Gutkind J Silvio
Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9017-22.
2006: Gu Jian; Wu Xifeng; Dong Qiong; Romeo Martin J; Lin Xin; Gutkind J Silvio; Berman David M
A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.
Cancer 2006;106(12):2716-24.
2006: Kehat Izhak; Heinrich Ronit; Ben-Izhak Ofer; Miyazaki Hiroshi; Gutkind J Silvio; Aronheim Ami
Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation.
Cardiovascular research 2006;70(3):543-54.
2006: Raimondi Ana R; Vitale-Cross Lynn; Amornphimoltham Panomwat; Gutkind J Silvio; Molinolo Alfredo
Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter.
The American journal of pathology 2006;168(5):1654-65.
2006: Miyazaki Hiroshi; Patel Vyomesh; Wang Huixin; Edmunds Ryan K; Gutkind J Silvio; Yeudall W Andrew
Down-regulation of CXCL5 inhibits squamous carcinogenesis.
Cancer research 2006;66(8):4279-84.
2006: Kaur Sukhbir; Castellone Maria Domenica; Bedell Victoria M; Konar Martha; Gutkind J Silvio; Ramchandran Ramani
Robo4 signaling in endothelial cells implies attraction guidance mechanisms.
The Journal of biological chemistry 2006;281(16):11347-56.
2006: Gelbard Alexander; Garnett Charlie T; Abrams Scott I; Patel Vyomesh; Gutkind J Silvio; Palena Claudia; Tsang Kwong-Yok; Schlom Jeffrey; Hodge James W
Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1897-905.
2006: Miyazaki Hiroshi; Patel Vyomesh; Wang Huixin; Ensley John F; Gutkind J Silvio; Yeudall W Andrew
Growth factor-sensitive molecular targets identified in primary and metastatic head and neck squamous cell carcinoma using microarray analysis.
Oral oncology 2006;42(3):240-56.
2006: Montaner Silvia; Sodhi Akrit; Ramsdell Amanda K; Martin Daniel; Hu Jiadi; Sawai Earl T; Gutkind J Silvio
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma.
Cancer research 2006;66(1):168-74.
2006: Rosenfeldt Hans; Castellone Maria Domenica; Randazzo Paul A; Gutkind J Silvio
Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk.
Journal of molecular signaling 2006;1():8.
2006: Kesavapany Sashi; Pareek Tej Kumar; Zheng Ya-Li; Amin Niranjana; Gutkind J Silvio; Ma Wu; Kulkarni Ashok B; Grant Philip; Pant Harish C
Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1.
Neuro-Signals 2006;15(4):157-73.
2005: Castellone Maria Domenica; Teramoto Hidemi; Williams Bart O; Druey Kirk M; Gutkind J Silvio
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.
Science (New York, N.Y.) 2005;310(5753):1504-10.
2005: Amornphimoltham Panomwat; Patel Vyomesh; Sodhi Akrit; Nikitakis Nikolaos G; Sauk John J; Sausville Edward A; Molinolo Alfredo A; Gutkind J Silvio
Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.
Cancer research 2005;65(21):9953-61.
2005: Monje Paula; Hernández-Losa Javier; Lyons Ruth J; Castellone Maria D; Gutkind J Silvio
Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.
The Journal of biological chemistry 2005;280(42):35081-4.
2005: List Karin; Szabo Roman; Molinolo Alfredo; Sriuranpong Virote; Redeye Vivien; Murdock Tricia; Burke Beth; Nielsen Boye S; Gutkind J Silvio; Bugge Thomas H
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.
Genes & development 2005;19(16):1934-50.
2005: Basile John R; Afkhami Talayeh; Gutkind J Silvio
Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.
Molecular and cellular biology 2005;25(16):6889-98.
2005: Marinissen Maria Julia; Gutkind J Silvio
Scaffold proteins dictate Rho GTPase-signaling specificity.
Trends in biochemical sciences 2005;30(8):423-6.
2005: Yeudall W Andrew; Miyazaki Hiroshi; Ensley John F; Cardinali Massimo; Gutkind J Silvio; Patel Vyomesh
Uncoupling of epidermal growth factor-dependent proliferation and invasion in a model of squamous carcinoma progression.
Oral oncology 2005;41(7):698-708.
2005: Patel Vyomesh; Ramesh Arun; Traicoff June L; Baibakov Galina; Emmert-Buck Michael R; Gutkind J Silvio; Knezevic Vladimir
Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology.
Oral oncology 2005;41(5):503-8.
2005: Tanos Tamara; Marinissen Maria Julia; Leskow Federico Coluccio; Hochbaum Daniel; Martinetto Horacio; Gutkind J Silvio; Coso Omar A
Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.
The Journal of biological chemistry 2005;280(19):18842-52.
2005: Dennis Phillip A; Van Waes Carter; Gutkind J Silvio; Kellar Kenneth J; Vinson Charles; Mukhin Alexey G; Spitz Margaret R; Bailey-Wilson Joan E; Yeh Grace Chao; Anderson Lucy M; Wiest Jonathan S
The biology of tobacco and nicotine: bench to bedside.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(4):764-7.
2005: Baker Haven; Patel Vyomesh; Molinolo Alfredo A; Shillitoe Edward J; Ensley John F; Yoo George H; Meneses-García Abelardo; Myers Jeffrey N; El-Naggar Adel K; Gutkind J S; Hancock William S
Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry.
Oral oncology 2005;41(2):183-99.
2005: Brantley Eileen; Patel Vyomesh; Stinson Sherman F; Trapani Valentina; Hose Curtis D; Ciolino Henry P; Yeh Grace C; Gutkind J Silvio; Sausville Edward A; Loaiza-Pérez Andrea I
The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappaB activity in drug-sensitive MCF-7 cells.
Anti-cancer drugs 2005;16(2):137-43.
2005: Teramoto Hidemi; Castellone Maria Domenica; Malek Renae L; Letwin Noah; Frank Bryan; Gutkind J Silvio; Lee Norman H
Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12.
Oncogene 2005;24(3):489-501.
2004: Vitale-Cross Lynn; Amornphimoltham Panomwat; Fisher Galen; Molinolo Alfredo A; Gutkind J Silvio
Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.
Cancer research 2004;64(24):8804-7.
2004: Sodhi Akrit; Montaner Silvia; Gutkind J Silvio
Viral hijacking of G-protein-coupled-receptor signalling networks.
Nature reviews. Molecular cell biology 2004;5(12):998-1012.
2004: Vázquez-Prado José; Miyazaki Hiroshi; Castellone Maria Domenica; Teramoto Hidemi; Gutkind J Silvio
Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.
The Journal of biological chemistry 2004;279(52):54283-90.
2004: Curino Alejandro; Patel Vyomesh; Nielsen Boye S; Iskander Andrew J; Ensley John F; Yoo George H; Holsinger F Christopher; Myers Jeffrey N; El-Nagaar Adel; Kellman Robert M; Shillitoe Edward J; Molinolo Alfredo A; Gutkind J Silvio; Bugge Thomas H
Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography.
Oral oncology 2004;40(10):1026-32.
2004: Jeon Geoung A; Lee Ju-Seog; Patel Vyomesh; Gutkind J Silvio; Thorgeirsson Snorri S; Kim Eun Cheol; Chu In-Sun; Amornphimoltham Panomwat; Park Myung Hee
Global gene expression profiles of human head and neck squamous carcinoma cell lines.
International journal of cancer. Journal international du cancer 2004;112(2):249-58.
2004: Montaner Silvia; Sodhi Akrit; Servitja Joan-Marc; Ramsdell Amanda K; Barac Ana; Sawai Earl T; Gutkind J Silvio
The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia.
Blood 2004;104(9):2903-11.
2004: Rosenfeldt Hans; Vázquez-Prado José; Gutkind J Silvio
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
FEBS letters 2004;572(1-3):167-71.
2004: Sriuranpong Virote; Mutirangura Apiwat; Gillespie John W; Patel Vyomesh; Amornphimoltham Panomwat; Molinolo Alfredo A; Kerekhanjanarong Veerachai; Supanakorn Siripornchai; Supiyaphun Pakpoom; Rangdaeng Samreung; Voravud Narin; Gutkind J Silvio
Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):4944-58.
2004: Basile John R; Barac Ana; Zhu Tianqing; Guan Kun-Liang; Gutkind J Silvio
Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.
Cancer research 2004;64(15):5212-24.
2004: Oliva José Luis; Zarich Natasha; Martínez Natalia; Jorge Rocío; Castrillo Antonio; Azañedo Marta; García-Vargas Susana; Gutiérrez-Eisman Silvia; Juarranz Angeles; Boscá Lisardo; Gutkind J Silvio; Rojas José M
The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.
The Journal of biological chemistry 2004;279(32):33480-91.
2004: Amornphimoltham Panomwat; Sriuranpong Virote; Patel Vyomesh; Benavides Fernando; Conti Claudio J; Sauk John; Sausville Edward A; Molinolo Alfredo A; Gutkind J Silvio
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 1):4029-37.
2004: Kesavapany Sashi; Amin Niranjana; Zheng Ya-Li; Nijhara Ruchika; Jaffe Howard; Sihag Ram; Gutkind J Silvio; Takahashi Satoru; Kulkarni Ashok; Grant Philip; Pant Harish C
p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(18):4421-31.
2004: Marinissen Maria Julia; Chiariello Mario; Tanos Tamara; Bernard Ora; Narumiya Shuh; Gutkind J Silvio
The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.
Molecular cell 2004;14(1):29-41.
2004: Sodhi Akrit; Montaner Silvia; Patel Vyomesh; Gómez-Román José Javier; Li Yi; Sausville Edward A; Sawai Earl T; Gutkind J Silvio
Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(14):4821-6.
2004: Sodhi Akrit; Montaner Silvia; Gutkind J Silvio
Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis?
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(3):422-7.
2004: Barac Ana; Basile John; Vázquez-Prado José; Gao Yuan; Zheng Yi; Gutkind J Silvio
Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor.
The Journal of biological chemistry 2004;279(7):6182-9.
2004: Chikumi Hiroki; Barac Ana; Behbahani Babak; Gao Yuan; Teramoto Hidemi; Zheng Yi; Gutkind J Silvio
Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential.
Oncogene 2004;23(1):233-40.
2004: Vázquez-Prado José; Basile John; Gutkind J Silvio
Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors.
Methods in enzymology 2004;390():259-85.
2004: Crespo Piero; Gutkind J Silvio
Activation of MAPKs by G protein-coupled receptors.
Methods in molecular biology (Clifton, N.J.) 2004;250():203-10.
2003: Iavarone Carlo; Catania Annunziata; Marinissen Maria Julia; Visconti Roberta; Acunzo Mario; Tarantino Carolina; Carlomagno M Stella; Bruni Carmelo B; Gutkind J Silvio; Chiariello Mario
The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway.
The Journal of biological chemistry 2003;278(50):50024-30.
2003: Marinissen Maria Julia; Servitja Joan-Marc; Offermanns Stefan; Simon Melvin I; Gutkind J Silvio
Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.
The Journal of biological chemistry 2003;278(47):46814-25.
2003: Monje Paula; Marinissen Maria Julia; Gutkind J Silvio
Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor.
Molecular and cellular biology 2003;23(19):7030-43.
2003: Igishi Tadashi; Mikami Masaaki; Murakami Kaori; Matsumoto Shingo; Shigeoka Yasushi; Nakanishi Hirofumi; Yasuda Kazuhito; Gutkind J Silvio; Hitsuda Yutaka; Shimizu Eiji
Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells.
International journal of oncology 2003;23(4):1079-85.
2003: Servitja Joan-Marc; Marinissen Maria Julia; Sodhi Akrit; Bustelo Xosé R; Gutkind J Silvio
Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.
The Journal of biological chemistry 2003;278(36):34339-46.
2003: Pedersen Tanja Xenia; Leethanakul Chidchanop; Patel Vyomesh; Mitola David; Lund Leif Røge; Danø Keld; Johnsen Morten; Gutkind J Silvio; Bugge Thomas Henrik
Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma.
Oncogene 2003;22(25):3964-76.
2003: Sriuranpong Virote; Park Jong In; Amornphimoltham Panomwat; Patel Vyomesh; Nelkin Barry D; Gutkind J Silvio
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.
Cancer research 2003;63(11):2948-56.
2003: Teramoto Hidemi; Malek Renae L; Behbahani Babak; Castellone Maria Domenica; Lee Norman H; Gutkind J Silvio
Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes.
Oncogene 2003;22(17):2689-97.
2003: Leethanakul C; Knezevic V; Patel V; Amornphimoltham P; Gillespie J; Shillitoe E J; Emko P; Park M H; Emmert-Buck M R; Strausberg R L; Krizman D B; Gutkind J S;
Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis.
Oral oncology 2003;39(3):248-58.
2003: Nishigaki Kazuo; Thompson Delores; Yugawa Takashi; Rulli Karen; Hanson Charlotte; Cmarik Joan; Gutkind J Silvio; Teramoto Hidemi; Ruscetti Sandra
Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase.
The Journal of biological chemistry 2003;278(15):13520-30.
2003: Servitja Joan-Marc; Masgrau Roser; Pardo Raul; Sarri Elisabet; von Eichel-Streiber Christoph; Gutkind J Silvio; Picatoste Fernando
Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.
Neuropharmacology 2003;44(2):171-80.
2003: Montaner Silvia; Sodhi Akrit; Molinolo Alfredo; Bugge Thomas H; Sawai Earl T; He Yunsheng; Li Yi; Ray Patricio E; Gutkind J Silvio
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes.
Cancer cell 2003;3(1):23-36.
2002: Guo Yan-Shi; Cheng Ji-Zhong; Jin Gui-Fang; Gutkind J Silvio; Hellmich Mark R; Townsend Courtney M
Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor.
The Journal of biological chemistry 2002;277(50):48755-63.
2002: Patel Vyomesh; Lahusen Tyler; Leethanakul Chidchanok; Igishi Tadashi; Kremer Marcus; Quintanilla-Martinez Leticia; Ensley John F; Sausville Edward A; Gutkind J Silvio; Senderowicz Adrian M
Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3549-60.
2002: Perrot Valerie; Vazquez-Prado Jose; Gutkind J Silvio
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.
The Journal of biological chemistry 2002;277(45):43115-20.
2002: Katz Ben-Zion; Miyamoto Shingo; Teramoto Hidemi; Zohar Muriel; Krylov Dmitry; Vinson Charles; Gutkind J Silvio; Yamada Kenneth M
Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation.
Biochimica et biophysica acta 2002;1592(2):141-52.
2002: Aurandt Jennifer; Vikis Haris G; Gutkind J Silvio; Ahn Natalie; Guan Kun-Liang
The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12085-90.
2002: Choi Yong; Zhang Jie; Murga Cristina; Yu Hong; Koller Erich; Monia Brett P; Gutkind J Silvio; Li Weiqun
PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
Oncogene 2002;21(34):5289-300.
2002: Chikumi Hiroki; Vázquez-Prado José; Servitja Joan-Marc; Miyazaki Hiroshi; Gutkind J Silvio
Potent activation of RhoA by Galpha q and Gq-coupled receptors.
The Journal of biological chemistry 2002;277(30):27130-4.
2002: Patel Vyomesh; Aldridge Kay; Ensley John F; Odell Edward; Boyd Andrea; Jones Judith; Gutkind J Silvio; Yeudall W Andrew
Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2002;99(4):583-8.
2002: Pece Salvatore; Gutkind J Silvio
E-cadherin and Hakai: signalling, remodeling or destruction?
Nature cell biology 2002;4(4):E72-4.
2002: Chikumi Hiroki; Fukuhara Shigetomo; Gutkind J Silvio
Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase.
The Journal of biological chemistry 2002;277(14):12463-73.
2002: Patel Vyomesh; Lahusen Tyler; Sy Terence; Sausville Edward A; Gutkind J Sivio; Senderowicz Adrian M
Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.
Cancer research 2002;62(5):1401-9.
2002: Chen Hua-Wei; Marinissen Maria Julia; Oh Su-Wan; Chen Xiu; Melnick Michael; Perrimon Norbert; Gutkind J Silvio; Hou Steven X
CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila.
Molecular and cellular biology 2002;22(6):1792-803.
2002: Régnauld Karine L; Leteurtre Emmanuelle; Gutkind Silvio J; Gespach Christian P; Emami Shahin
Activation of adenylyl cyclases, regulation of insulin status, and cell survival by G(alpha)olf in pancreatic beta-cells.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(3):R870-80.
2002: Orsulic Sandra; Li Yi; Soslow Robert A; Vitale-Cross Lynn A; Gutkind J Silvio; Varmus Harold E
Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.
Cancer cell 2002;1(1):53-62.
2002: de Sousa Suzana Orsini Machado; Mesquita Ricardo Alves; Pinto Décio Santos; Gutkind Silvio
Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2002;31(2):78-81.
2002: Chen Hua-Wei; Chen Xiu; Oh Su-Wan; Marinissen Maria J; Gutkind J Silvio; Hou Steven X
mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family.
Genes & development 2002;16(3):388-98.
2002: Sanchez-Prieto Ricardo; Sanchez-Arevalo Victor Javier; Servitja Joan-Marc; Gutkind J Silvio
Regulation of p73 by c-Abl through the p38 MAP kinase pathway.
Oncogene 2002;21(6):974-9.
2002: Sakabe Kaoru; Teramoto Hidemi; Zohar Muriel; Behbahani Babak; Miyazaki Hiroshi; Chikumi Hiroki; Gutkind J Silvio
Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: evidence for a role of a p38gamma-dependent signaling pathway.
FEBS letters 2002;511(1-3):15-20.
2002: Murga Cristina; Zohar Muriel; Teramoto Hidemi; Gutkind J Silvio
Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB.
Oncogene 2002;21(2):207-16.
2002: Segrelles Carmen; Ruiz Sergio; Perez Paloma; Murga Cristina; Santos Mirentxu; Budunova Irina V; Martínez Jesús; Larcher Fernando; Slaga Thomas J; Gutkind J Silvio; Jorcano Jose L; Paramio Jesús M
Functional roles of Akt signaling in mouse skin tumorigenesis.
Oncogene 2002;21(1):53-64.
2002: Chiariello Mario; Gutkind J Silvio
Regulation of mitogen-activated protein kinases by G-protein-coupled receptors.
Methods in enzymology 2002;345():437-47.
2001: Knezevic V; Leethanakul C; Bichsel V E; Worth J M; Prabhu V V; Gutkind J S; Liotta L A; Munson P J; Petricoin E F; Krizman D B
Proteomic profiling of the cancer microenvironment by antibody arrays.
Proteomics 2001;1(10):1271-8.
2001: Sodhi A; Montaner S; Miyazaki H; Gutkind J S
MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.
Biochemical and biophysical research communications 2001;287(1):292-300.
2001: Yuan P X; Huang L D; Jiang Y M; Gutkind J S; Manji H K; Chen G
The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth.
The Journal of biological chemistry 2001;276(34):31674-83.
2001: Longenecker K L; Lewis M E; Chikumi H; Gutkind J S; Derewenda Z S
Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases.
Structure (London, England : 1993) 2001;9(7):559-69.
2001: Marinissen M J; Gutkind J S
G-protein-coupled receptors and signaling networks: emerging paradigms.
Trends in pharmacological sciences 2001;22(7):368-76.
2001: Chiariello M; Marinissen M J; Gutkind J S
Regulation of c-myc expression by PDGF through Rho GTPases.
Nature cell biology 2001;3(6):580-6.
2001: Dong F; Gutkind J S; Larner A C
Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival.
The Journal of biological chemistry 2001;276(14):10811-6.
2001: Fukuhara S; Chikumi H; Gutkind J S
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
Oncogene 2001;20(13):1661-8.
2001: Montaner S; Sodhi A; Pece S; Mesri E A; Gutkind J S
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B.
Cancer research 2001;61(6):2641-8.
2001: Marinissen M J; Chiariello M; Gutkind J S
Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.
Genes & development 2001;15(5):535-53.
2001: Patel V; Leethanakul C; Gutkind J S
New approaches to the understanding of the molecular basis of oral cancer.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 2001;12(1):55-63.
2000: Patel V; Ensley J F; Gutkind J S; Yeudall W A
Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma-irradiation and bleomycin is p53-independent.
International journal of cancer. Journal international du cancer 2000;88(5):737-43.
2000: Pece S; Gutkind J S
Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation.
The Journal of biological chemistry 2000;275(52):41227-33.
2000: Fukuhara S; Chikumi H; Gutkind J S
Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.
FEBS letters 2000;485(2-3):183-8.
2000: Hyun T; Yam A; Pece S; Xie X; Zhang J; Miki T; Gutkind J S; Li W
Loss of PTEN expression leading to high Akt activation in human multiple myelomas.
Blood 2000;96(10):3560-8.
2000: Du Villard J A; Wicker R; Crespo P; Russo D; Filetti S; Gutkind J S; Sarasin A; Suárez H G
Role of the cAMP and MAPK pathways in the transformation of mouse 3T3 fibroblasts by a TSHR gene constitutively activated by point mutation.
Oncogene 2000;19(42):4896-905.
2000: Sodhi A; Montaner S; Patel V; Zohar M; Bais C; Mesri E A; Gutkind J S
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
Cancer research 2000;60(17):4873-80.
2000: Leethanakul C; Patel V; Gillespie J; Shillitoe E; Kellman R M; Ensley J F; Limwongse V; Emmert-Buck M R; Krizman D B; Gutkind J S
Gene expression profiles in squamous cell carcinomas of the oral cavity: use of laser capture microdissection for the construction and analysis of stage-specific cDNA libraries.
Oral oncology 2000;36(5):474-83.
2000: Visconti R; Gadina M; Chiariello M; Chen E H; Stancato L F; Gutkind J S; O'Shea J J
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.
Blood 2000;96(5):1844-52.
2000: Izevbigie E B; Gutkind J S; Ray P E
Isoproterenol inhibits fibroblast growth factor-2-induced growth of renal epithelial cells.
Pediatric nephrology (Berlin, Germany) 2000;14(8-9):726-34.
2000: Chiariello M; Gomez E; Gutkind J S
Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G1 phase.
The Biochemical journal 2000;349 Pt 3():869-76.
2000: Arozarena I; Aaronson D S; Matallanas D; Sanz V; Ajenjo N; Tenbaum S P; Teramoto H; Ighishi T; Zabala J C; Gutkind J S; Crespo P
The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF.
The Journal of biological chemistry 2000;275(34):26441-8.
2000: Gutkind J S
Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors.
Science's STKE : signal transduction knowledge environment 2000;2000(40):re1.
2000: Pirone D M; Fukuhara S; Gutkind J S; Burbelo P D
SPECs, small binding proteins for Cdc42.
The Journal of biological chemistry 2000;275(30):22650-6.
2000: Fukuhara S; Marinissen M J; Chiariello M; Gutkind J S
Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway.
The Journal of biological chemistry 2000;275(28):21730-6.
2000: Leethanakul C; Patel V; Gillespie J; Pallente M; Ensley J F; Koontongkaew S; Liotta L A; Emmert-Buck M; Gutkind J S
Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays.
Oncogene 2000;19(28):3220-4.
2000: Katz B Z; Zohar M; Teramoto H; Matsumoto K; Gutkind J S; Lin D C; Lin S; Yamada K M
Tensin can induce JNK and p38 activation.
Biochemical and biophysical research communications 2000;272(3):717-20.
2000: Izevbigie E B; Gutkind J S; Ray P E
Angiotensin II and basic fibroblast growth factor mitogenic pathways in human fetal mesangial cells.
Pediatric research 2000;47(5):614-21.
2000: Sanchez-Prieto R; Rojas J M; Taya Y; Gutkind J S
A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents.
Cancer research 2000;60(9):2464-72.
2000: Fukuhara S; Gutkind J S
A new twist for the tumour suppressor hamartin.
Nature cell biology 2000;2(5):E76-8.
2000: Murga C; Fukuhara S; Gutkind J S
A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt.
The Journal of biological chemistry 2000;275(16):12069-73.
2000: Majidi M; Gutkind J S; Lichy J H
Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells.
The Journal of biological chemistry 2000;275(9):6560-5.
2000: Chiariello M; Marinissen M J; Gutkind J S
Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation.
Molecular and cellular biology 2000;20(5):1747-58.
2000: Shillitoe E J; May M; Patel V; Lethanakul C; Ensley J F; Strausberg R L; Gutkind J S
Genome-wide analysis of oral cancer--early results from the Cancer Genome Anatomy Project.
Oral oncology 2000;36(1):8-16.
2000: Chiang Y J; Kole H K; Brown K; Naramura M; Fukuhara S; Hu R J; Jang I K; Gutkind J S; Shevach E; Gu H
Cbl-b regulates the CD28 dependence of T-cell activation.
Nature 2000;403(6766):216-20.
1999: Tassi E; Biesova Z; Di Fiore P P; Gutkind J S; Wong W T
Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor.
The Journal of biological chemistry 1999;274(47):33287-95.
1999: Igishi T; Fukuhara S; Patel V; Katz B Z; Yamada K M; Gutkind J S
Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation.
The Journal of biological chemistry 1999;274(43):30738-46.
1999: Lerga A; Crespo P; Berciano M; Delgado M D; Cañelles M; Calés C; Richard C; Ceballos E; Gutierrez P; Ajenjo N; Gutkind S; León J
Regulation of c-Myc and Max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase C modifiers: c-Myc is down-regulated but does not inhibit differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(9):639-54.
1999: Scita G; Nordstrom J; Carbone R; Tenca P; Giardina G; Gutkind S; Bjarnegård M; Betsholtz C; Di Fiore P P
EPS8 and E3B1 transduce signals from Ras to Rac.
Nature 1999;401(6750):290-3.
1999: Pece S; Chiariello M; Murga C; Gutkind J S
Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex.
The Journal of biological chemistry 1999;274(27):19347-51.
1999: Marinissen M J; Chiariello M; Pallante M; Gutkind J S
A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.
Molecular and cellular biology 1999;19(6):4289-301.
1999: Soon L; Flechner L; Gutkind J S; Wang L H; Baserga R; Pierce J H; Li W
Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.
Molecular and cellular biology 1999;19(5):3816-28.
1999: Heemskerk F M; Zorad S; Xu N; Gutkind S J; Saavedra J M
Characterization of AT2 receptor expression in NIH 3T3 fibroblasts.
Cellular and molecular neurobiology 1999;19(2):277-88.
1999: Fukuhara S; Murga C; Zohar M; Igishi T; Gutkind J S
A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.
The Journal of biological chemistry 1999;274(9):5868-79.
1999: Korn I; Gutkind S; Srinivasan N; Blundell T L; Allende C C; Allende J E
Interactions of protein kinase CK2 subunits.
Molecular and cellular biochemistry 1999;191(1-2):75-83.
1999: Janulis M; Silberman S; Ambegaokar A; Gutkind J S; Schultz R M
Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts.
The Journal of biological chemistry 1999;274(2):801-13.
1998: Patel V; Senderowicz A M; Pinto D; Igishi T; Raffeld M; Quintanilla-Martinez L; Ensley J F; Sausville E A; Gutkind J S
Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis.
The Journal of clinical investigation 1998;102(9):1674-81.
1998: Okubo Y; Blakesley V A; Stannard B; Gutkind S; Le Roith D
Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase.
The Journal of biological chemistry 1998;273(40):25961-6.
1998: Burstein E S; Hesterberg D J; Gutkind J S; Brann M R; Currier E A; Messier T L
The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptors.
Oncogene 1998;17(12):1617-23.
1998: Gutkind J S
Cell growth control by G protein-coupled receptors: from signal transduction to signal integration.
Oncogene 1998;17(11 Reviews):1331-42.
1998: Zohar M; Teramoto H; Katz B Z; Yamada K M; Gutkind J S
Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation.
Oncogene 1998;17(8):991-8.
1998: Murga C; Laguinge L; Wetzker R; Cuadrado A; Gutkind J S
Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma.
The Journal of biological chemistry 1998;273(30):19080-5.
1998: Deb T B; Wong L; Salomon D S; Zhou G; Dixon J E; Gutkind J S; Thompson S A; Johnson G R
A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation.
The Journal of biological chemistry 1998;273(27):16643-6.
1998: Winn D M; Sandberg A L; Horowitz A M; Diehl S R; Gutkind S; Kleinman D V
Reducing the burden of oral and pharyngeal cancers.
Journal of the California Dental Association 1998;26(6):445-51, 454.
1998: Winn D M; Diehl S R; Horowitz A M; Gutkind S; Sandberg A L; Kleinman D V
Scientific progress in understanding oral and pharyngeal cancers.
Journal of the American Dental Association (1939) 1998;129(6):713-8.
1998: Rubino D; Driggers P; Arbit D; Kemp L; Miller B; Coso O; Pagliai K; Gray K; Gutkind S; Segars J
Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action.
Oncogene 1998;16(19):2513-26.
1998: Chiariello M; Visconti R; Carlomagno F; Melillo R M; Bucci C; de Franciscis V; Fox G M; Jing S; Coso O A; Gutkind J S; Fusco A; Santoro M
Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.
Oncogene 1998;16(19):2435-45.
1998: Crespo P; Font de Mora J; Aaronson D S; Santos E; Gutkind J S
Transforming G protein-coupled receptors block insulin and ras-induced adipocytic differentiation in 3T3-L1 cells: evidence for a PKC and MAP kinase independent pathway.
Biochemical and biophysical research communications 1998;245(2):554-61.
1998: Igishi T; Gutkind J S
Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors.
Biochemical and biophysical research communications 1998;244(1):5-10.
1998: Jones T L; Gutkind J S
Galpha12 requires acylation for its transforming activity.
Biochemistry 1998;37(9):3196-202.
1998: Teramoto H; Gutkind J S
[The pathway connecting muscarinic acetylcholine receptors to the nucleus involves small GTP-binding proteins]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(1):35-41.
1998: Lopez-Ilasaca M; Gutkind J S; Wetzker R
Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation.
The Journal of biological chemistry 1998;273(5):2505-8.
1998: Gutkind J S
The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades.
The Journal of biological chemistry 1998;273(4):1839-42.
1998: Bais C; Santomasso B; Coso O; Arvanitakis L; Raaka E G; Gutkind J S; Asch A S; Cesarman E; Gershengorn M C; Mesri E A;
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator.
Nature 1998;391(6662):86-9.
1997: Bustelo X R; Crespo P; López-Barahona M; Gutkind J S; Barbacid M
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.
Oncogene 1997;15(21):2511-20.
1997: Liu J L; Blakesley V A; Gutkind J S; LeRoith D
The constitutively active mutant Galpha13 transforms mouse fibroblast cells deficient in insulin-like growth factor-I receptor.
The Journal of biological chemistry 1997;272(47):29438-41.
1997: Jin D Y; Teramoto H; Giam C Z; Chun R F; Gutkind J S; Jeang K T
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.
The Journal of biological chemistry 1997;272(41):25816-23.
1997: Fromm C; Coso O A; Montaner S; Xu N; Gutkind J S
The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10098-103.
1997: Uren A; Jakus J; Font de Mora J; Yeudall A; Santos E; Gutkind S; Heidaran M A
Carboxyl-terminal domain of p27Kip1 activates CDC2.
The Journal of biological chemistry 1997;272(35):21669-72.
1997: Coso O A; Montaner S; Fromm C; Lacal J C; Prywes R; Teramoto H; Gutkind J S
Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway.
The Journal of biological chemistry 1997;272(33):20691-7.
1997: Alimandi M; Heidaran M A; Gutkind J S; Zhang J; Ellmore N; Valius M; Kazlauskas A; Pierce J H; Li W
PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells.
Oncogene 1997;15(5):585-93.
1997: Buckbinder L; Velasco-Miguel S; Chen Y; Xu N; Talbott R; Gelbert L; Gao J; Seizinger B R; Gutkind J S; Kley N
The p53 tumor suppressor targets a novel regulator of G protein signaling.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7868-72.
1997: Herrera L; Hinrichs M V; Frías J; Gutkind S; Olate J
Dual transduction signaling by a Xenopus muscarinic receptor: adenylyl cyclase inhibition and MAP kinase activation.
Journal of cellular biochemistry 1997;65(1):75-82.
1997: Teramoto H; Salem P; Robbins K C; Bustelo X R; Gutkind J S
Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway.
The Journal of biological chemistry 1997;272(16):10751-5.
1997: Lopez-Ilasaca M; Li W; Uren A; Yu J C; Kazlauskas A; Gutkind J S; Heidaran M A
Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF.
Biochemical and biophysical research communications 1997;232(2):273-7.
1997: Gordeladze J O; Høvik K E; Merendino J J; Hermouet S; Gutkind S; Accili D
Effect of activating and inactivating mutations of Gs- and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes.
Journal of cellular biochemistry 1997;64(2):242-57.
1997: Lopez-Ilasaca M; Crespo P; Pellici P G; Gutkind J S; Wetzker R
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma.
Science (New York, N.Y.) 1997;275(5298):394-7.
1997: Crespo P; Schuebel K E; Ostrom A A; Gutkind J S; Bustelo X R
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.
Nature 1997;385(6612):169-72.
1997: Gutkind J S; Crespo P; Xu N; Teramoto H; Coso O A
The pathway connecting m2 receptors to the nucleus involves small GTP-binding proteins acting on divergent MAP kinase cascades.
Life sciences 1997;60(13-14):999-1006.
1996: Miyamoto S; Teramoto H; Gutkind J S; Yamada K M
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.
The Journal of cell biology 1996;135(6 Pt 1):1633-42.
1996: Zhang S; Coso O A; Lee C; Gutkind J S; Simonds W F
Selective activation of effector pathways by brain-specific G protein beta5.
The Journal of biological chemistry 1996;271(52):33575-9.
1996: Teramoto H; Coso O A; Miyata H; Igishi T; Miki T; Gutkind J S
Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family.
The Journal of biological chemistry 1996;271(44):27225-8.
1996: Teramoto H; Crespo P; Coso O A; Igishi T; Xu N; Gutkind J S
The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway.
The Journal of biological chemistry 1996;271(42):25731-4.
1996: Sundaresan M; Yu Z X; Ferrans V J; Sulciner D J; Gutkind J S; Irani K; Goldschmidt-Clermont P J; Finkel T
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.
The Biochemical journal 1996;318 ( Pt 2)():379-82.
1996: Crespo P; Bustelo X R; Aaronson D S; Coso O A; Lopez-Barahona M; Barbacid M; Gutkind J S
Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.
Oncogene 1996;13(3):455-60.
1996: Zhang S; Coso O A; Collins R; Gutkind J S; Simonds W F
A C-terminal mutant of the G protein beta subunit deficient in the activation of phospholipase C-beta.
The Journal of biological chemistry 1996;271(33):20208-12.
1996: Kieser A; Seitz T; Adler H S; Coffer P; Kremmer E; Crespo P; Gutkind J S; Henderson D W; Mushinski J F; Kolch W; Mischak H
Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells.
Genes & development 1996;10(12):1455-66.
1996: Cuvillier O; Pirianov G; Kleuser B; Vanek P G; Coso O A; Gutkind S; Spiegel S
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.
Nature 1996;381(6585):800-3.
1996: Xu N; Coso O; Mahadevan D; De Blasi A; Goldsmith P K; Simonds W F; Gutkind J S
The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins.
Cellular and molecular neurobiology 1996;16(1):51-9.
1996: Coso O A; Teramoto H; Simonds W F; Gutkind J S
Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway.
The Journal of biological chemistry 1996;271(8):3963-6.
1995: Miyamoto S; Teramoto H; Coso O A; Gutkind J S; Burbelo P D; Akiyama S K; Yamada K M
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.
The Journal of cell biology 1995;131(3):791-805.
1995: Crespo P; Cachero T G; Xu N; Gutkind J S
Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition.
The Journal of biological chemistry 1995;270(42):25259-65.
1995: Crespo P; Mischak H; Gutkind J S
Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells.
Biochemical and biophysical research communications 1995;213(1):266-72.
1995: Coso O A; Chiariello M; Yu J C; Teramoto H; Crespo P; Xu N; Miki T; Gutkind J S
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway.
Cell 1995;81(7):1137-46.
1995: Coso O A; Chiariello M; Kalinec G; Kyriakis J M; Woodgett J; Gutkind J S
Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway.
The Journal of biological chemistry 1995;270(10):5620-4.
1994: Yu J C; Gutkind J S; Mahadevan D; Li W; Meyers K A; Pierce J H; Heidaran M A
Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.
The Journal of cell biology 1994;127(2):479-87.
1994: Crespo P; Xu N; Daniotti J L; Troppmair J; Rapp U R; Gutkind J S
Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.
The Journal of biological chemistry 1994;269(33):21103-9.
1994: Calderon S N; Izenwasser S; Heller B; Gutkind J S; Mattson M V; Su T P; Newman A H
Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.
Journal of medicinal chemistry 1994;37(15):2285-91.
1994: Crespo P; Xu N; Simonds W F; Gutkind J S
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.
Nature 1994;369(6479):418-20.
1994: Xu N; Voyno-Yasenetskaya T; Gutkind J S
Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes.
Biochemical and biophysical research communications 1994;201(2):603-9.
1994: Xu N; McCormick F; Gutkind J S
The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors.
Oncogene 1994;9(2):597-601.
1993: Xu N; Bradley L; Ambdukar I; Gutkind J S
A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6741-5.
1993: Wang L M; Keegan A D; Li W; Lienhard G E; Pacini S; Gutkind J S; Myers M G; Sun X J; White M F; Aaronson S A
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4032-6.
1993: Stephens E V; Kalinec G; Brann M R; Gutkind J S
Transforming G protein-coupled receptors transduce potent mitogenic signals in NIH 3T3 cells independent on cAMP inhibition or conventional protein kinase C.
Oncogene 1993;8(1):19-26.
1992: Wang L M; Keegan A D; Paul W E; Heidaran M A; Gutkind J S; Pierce J H
IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells.
The EMBO journal 1992;11(13):4899-908.
1992: Gutkind J S; Robbins K C
Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate.
Biochemical and biophysical research communications 1992;188(1):155-61.
1992: Kalinec G; Nazarali A J; Hermouet S; Xu N; Gutkind J S
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells.
Molecular and cellular biology 1992;12(10):4687-93.
1992: Link D C; Gutkind S J; Robbins K C; Ley T J
Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.
Oncogene 1992;7(5):877-84.
1992: Thompson P A; Gutkind J S; Robbins K C; Ledbetter J A; Bolen J B
Identification of distinct populations of PI-3 kinase activity following T-cell activation.
Oncogene 1992;7(4):719-25.
1992: Stephan V; Benhamou M; Gutkind J S; Robbins K C; Siraganian R P
Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis.
The Journal of biological chemistry 1992;267(8):5434-41.
1992: Sartor O; Moriuchi R; Sameshima J H; Severino M; Gutkind J S; Robbins K C
Diverse biologic properties imparted by the c-fgr proto-oncogene.
The Journal of biological chemistry 1992;267(5):3460-5.
1991: Hermouet S; Merendino J J; Gutkind J S; Spiegel A M
Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10455-9.
1991: Yu J C; Heidaran M A; Pierce J H; Gutkind J S; Lombardi D; Ruggiero M; Aaronson S A
Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.
Molecular and cellular biology 1991;11(7):3780-5.
1991: Gutkind J S; Novotny E A; Brann M R; Robbins K C
Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4703-7.
1991: Gutkind J S; Link D C; Katamine S; Lacal P; Miki T; Ley T J; Robbins K C
A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.
Molecular and cellular biology 1991;11(3):1500-7.
1991: Gusovsky F; Gutkind J S
Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation.
Molecular pharmacology 1991;39(2):124-9.
1991: Heidaran M A; Pierce J H; Lombardi D; Ruggiero M; Gutkind J S; Matsui T; Aaronson S A
Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways.
Molecular and cellular biology 1991;11(1):134-42.
1990: Kazanietz M G; Gutkind J S; Enero M A
Effects of clenbuterol treatment on the responses to vasodilators in urethane-anaesthetized rats.
The Journal of pharmacy and pharmacology 1990;42(10):735-7.
1990: Gutkind J S; Lacal P M; Robbins K C
Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets.
Molecular and cellular biology 1990;10(7):3806-9.
1990: Benhamou M; Gutkind J S; Robbins K C; Siraganian R P
Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5327-30.
1990: Nazarali A J; Gutkind J S; Correa F M; Saavedra J M
Decreased angiotensin II receptors in subfornical organ of spontaneously hypertensive rats after chronic antihypertensive treatment with enalapril.
American journal of hypertension 1990;3(1):59-61.
1989: Notario V; Gutkind J S; Imaizumi M; Katamine S; Robbins K C
Expression of the fgr protooncogene product as a function of myelomonocytic cell maturation.
The Journal of cell biology 1989;109(6 Pt 1):3129-36.
1989: Nazarali A J; Gutkind J S; Saavedra J M
Calibration of 125I-polymer standards with 125I-brain paste standards for use in quantitative receptor autoradiography.
Journal of neuroscience methods 1989;30(3):247-53.
1989: Kazanietz M G; Gutkind J S; Puyo A; Armando I; Enero M A
Further evidence of interaction between vasodilator beta 2- and vasoconstrictor alpha 2-adrenoceptor-mediated responses in maintaining vascular tone in anesthetized rats.
Journal of cardiovascular pharmacology 1989;14(6):874-80.
1989: Gutkind J S; Robbins K C
Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8783-7.
1989: Nazarali A J; Gutkind J S; Correa F M; Saavedra J M
Enalapril decreases angiotensin II receptors in subfornical organ of SHR.
The American journal of physiology 1989;256(6 Pt 2):H1609-14.
1989: Gutkind J S; Kazanietz M G; Armando I; Puyó A; Enero M A
Pressor response induced by clenbuterol treatment in immobilized normotensive rats.
Journal of cardiovascular pharmacology 1989;13(5):793-8.
1989: Sugita K; Gutkind J S; Katamine S; Kawakami T; Robbins K C
The actin domain of Gardner-Rasheed feline sarcoma virus inhibits kinase and transforming activities.
Journal of virology 1989;63(4):1715-20.
1989: Saavedra J M; Castrén E; Gutkind J S; Nazarali A J
Regulation of brain atrial natriuretic peptide and angiotensin receptors: quantitative autoradiographic studies.
International review of neurobiology 1989;31():257-96.
1988: Nazarali A J; Gutkind J S; Correa F M; Saavedra J M
Effect of chronic administration of the converting enzyme inhibitor enalapril (MK 421) on brain atrial natriuretic peptide receptors in Wistar-Kyoto and spontaneously hypertensive rats.
Brain research 1988;475(1):134-40.
1988: Gutkind J S; Kurihara M; Saavedra J M
Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats.
The American journal of physiology 1988;255(3 Pt 2):H646-50.
1988: Gutkind J S; Kurihara M; Castrén E; Saavedra J M
Autoradiographic quantification of vasoactive intestinal peptide binding sites in sections from human blood mononuclear cell pellets.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1988;1(3):251-5.
1988: Kurihara M; Gutkind J S; Saavedra J M
Alteration of atrial natriuretic peptide binding sites in spontaneously hypertensive rats.
American journal of hypertension 1988;1(3 Pt 3):12S-14S.
1988: Kurihara M; Castrén E; Gutkind J S; Saito K; Saavedra J M
Characterization of beta-adrenergic receptors in sections from human blood lymphocyte pellets by quantitative autoradiography.
Biological psychiatry 1988;23(7):749-54.
1988: Gutkind J S; Kurihara M; Castren E; Saavedra J M
Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats.
Journal of hypertension 1988;6(1):79-84.
1988: Gutkind J S; Castrén E; Saavedra J M
Decreased angiotensin II binding affinity and binding capacity in the anterior pituitary gland of adult spontaneously hypertensive rats.
Life sciences 1988;43(5):445-51.
1987: Nazarali A J; Gutkind J S; Saavedra J M
Regulation of angiotensin II binding sites in the subfornical organ and other rat brain nuclei after water deprivation.
Cellular and molecular neurobiology 1987;7(4):447-55.
1987: Saito K; Gutkind J S; Saavedra J M
Angiotensin II binding sites in the conduction system of rat hearts.
The American journal of physiology 1987;253(6 Pt 2):H1618-22.
1987: Kurihara M; Castrén E; Gutkind J S; Saavedra J M
Lower number of atrial natriuretic peptide receptors in thymocytes and spleen cells of spontaneously hypertensive rats.
Biochemical and biophysical research communications 1987;149(3):1132-40.
1987: Gutkind J S; Kurihara M; Castrén E; Saavedra J M
Atrial natriuretic peptide receptors in sympathetic ganglia: biochemical response and alterations in genetically hypertensive rats.
Biochemical and biophysical research communications 1987;149(1):65-72.
1987: Castrén E; Kurihara M; Gutkind J S; Saavedra J M
Specific angiotensin II binding sites in the rat stellate and superior cervical ganglia.
Brain research 1987;422(2):347-51.
1986: Kazanietz M G; Gutkind J S; Enero M A
Interaction between beta 2- and alpha 2-adrenoceptor responses in the vascular system: effect of clenbuterol.
European journal of pharmacology 1986;130(1-2):119-24.
1986: Gutkind J S; Kazanietz M; Enero M A
Cardiovascular effects of alpha-adrenergic drugs: differences between clonidine and guanabenz.
Naunyn-Schmiedeberg's archives of pharmacology 1986;332(4):370-5.
1984: Gutkind J S; Enero M A
Treatment with clorgyline and pargyline differentially decreases clonidine-induced hypotension and bradycardia.
Naunyn-Schmiedeberg's archives of pharmacology 1984;327(3):189-92.

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