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Jeffrey Toney

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TOP 3
Peggy A Sanchez; Jeffrey Toney; Janice D Thomas; John M Berger
A sensitive coupled HPLC/electrospray mass spectrometry assay for SPM-1 metallo-beta-lactamase inhibitors.
Janice D Thomas; Joseph G Moloughney; Jeffrey Toney
Old drugs resurrected?
Jeffrey Toney
Big payoffs possible for small-molecule screening.

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All Publications

2009: Peggy A Sanchez; Jeffrey Toney; Janice D Thomas; John M Berger
A sensitive coupled HPLC/electrospray mass spectrometry assay for SPM-1 metallo-beta-lactamase inhibitors.
Assay and drug development technologies 2009;7(2):170-9.
2009: Janice D Thomas; Joseph G Moloughney; Jeffrey Toney
Old drugs resurrected?
Current opinion in investigational drugs (London, England : 2000) 2009;10(2):119-20.
2008: Jeffrey Toney
Big payoffs possible for small-molecule screening.
Science (New York, N.Y.) 2008;322(5898):46.
2007: Jeffrey Toney
Biofilms--a neglected antibacterial target?
Current opinion in investigational drugs (London, England : 2000) 2007;8(8):598-9.
2006: Ursula Theuretzbacher; Jeffrey Toney
Nature's clarion call of antibacterial resistance: are we listening?
Current opinion in investigational drugs (London, England : 2000) 2006;7(2):158-66.
2005: Nandini Sharma; Jeffrey Toney; Paula M D Fitzgerald
Expression, purification, crystallization and preliminary X-ray analysis of Aeromonas hydrophilia metallo-beta-lactamase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 2):180-2.
2005: Joseph G Moloughney; Janice D Thomas; Jeffrey Toney
Novel IMP-1 metallo-beta-lactamase inhibitors can reverse meropenem resistance in Escherichia coli expressing IMP-1.
FEMS microbiology letters 2005;243(1):65-71.
2004: Jeffrey Toney; Joseph G Moloughney
Metallo-beta-lactamase inhibitors: promise for the future?
Current opinion in investigational drugs (London, England : 2000) 2004;5(8):823-6.
2004: Jeffrey Toney; Sonia Navas-Martín; Susan R Weiss; Andreas Koeller
Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design.
Journal of medicinal chemistry 2004;47(5):1079-80.
2003: Jeffrey Toney; Aimie Ogawa; Megan Blair; Young-Whan Park
A "mix and read" assay for insulin using fluorometric microvolume assay technology.
Assay and drug development technologies 2003;1(4):521-5.
2003: Jeffrey Toney
Metallo-beta-lactamase inhibitors: could they give old antibacterials new life?
Current opinion in investigational drugs (London, England : 2000) 2003;4(2):115-6.
2002: Jeffrey Toney
Iseganan (IntraBiotics pharmaceuticals).
Current opinion in investigational drugs (London, England : 2000) 2002;3(2):225-8.
2001: Jeffrey Toney; GG Hammond; Paula M D Fitzgerald; N Sharma; James M Balkovec; Gregory P Rouen; Steven H Olson; Milton L Hammond; Mark L Greenlee; Y D Gao
Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase.
The Journal of biological chemistry 2001;276(34):31913-8.
2000: Barbara G Green; Jeffrey Toney; John W Kozarich; Stephan K Grant
Inhibition of bacterial peptide deformylase by biaryl acid analogs.
Archives of biochemistry and biophysics 2000;375(2):355-8.
1999: GG Hammond; JL Huber; Mark L Greenlee; JB Laub; Katherine Young; Lynn Silver; James M Balkovec; KellyAnn D Pryor; JK Wu; Barbara Leiting; DL Pompliano; Jeffrey Toney
Inhibition of IMP-1 metallo-beta-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives.
FEMS microbiology letters 1999;179(2):289-96.
1999: Jeffrey Toney; K A Cleary; GG Hammond; X Yuan; WJ May; S M Hutchins; W T Ashton; Dana E Vanderwall
Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(18):2741-6.
1998: Paula M D Fitzgerald; JK Wu; Jeffrey Toney
Unanticipated inhibition of the metallo-beta-lactamase from Bacteroides fragilis by 4-morpholineethanesulfonic acid (MES): a crystallographic study at 1.85-A resolution.
Biochemistry 1998;37(19):6791-800.
1998: Jeffrey Toney; Paula M D Fitzgerald; N Grover-Sharma; Steven H Olson; WJ May; Jon Sundelof; Dana E Vanderwall; K A Cleary; Stephan K Grant; JK Wu; John W Kozarich; DL Pompliano; GG Hammond
Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase.
Chemistry & biology 1998;5(4):185-96.
1998: Jeffrey Toney; GG Hammond; Barbara Leiting; KellyAnn D Pryor; JK Wu; G C Cuca; DL Pompliano
Soluble penicillin-binding protein 2a: beta-lactam binding and inhibition by non-beta-lactams using a 96-well format.
Analytical biochemistry 1998;255(1):113-9.
1997: Jeffrey Toney; JK Wu; K M Overbye; Chris Thompson; DL Pompliano
High-yield expression, purification, and characterization of active, soluble Bacteroides fragilis metallo-beta-lactamase, CcrA.
Protein expression and purification 1997;9(3):355-62.
1997: Richard L Tolman; Soumya P Sahoo; R K Bakshi; Dominick F Gratale; G Patel; S Patel; Jeffrey Toney; B Chang; Georgianna S Harris
4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro].
The Journal of steroid biochemistry and molecular biology 1997;60(5-6):303-9.
1997: Jeffrey Toney; Y Chen; S J Rutledge; A Schmidt; A Elbrecht
Non-steroidal L-245,976 acts as a classical antiandrogen in vitro.
The Journal of steroid biochemistry and molecular biology 1997;60(1-2):131-6.
1996: Ken Ellsworth; B Azzolina; W Baginsky; Herbert G Bull; B Chang; G Cimis; S Mitra; Jeffrey Toney; R K Bakshi; G R Rasmusson; Richard L Tolman; Georgianna S Harris
MK386: a potent, selective inhibitor of the human type 1 5alpha-reductase.
The Journal of steroid biochemistry and molecular biology 1996;58(4):377-84.
1995: A E Summerfield; P J Diaz Cruz; M P Dolenga; H E Smith; Catherine D Strader; Jeffrey Toney
Tissue-specific pharmacology of testosterone and 5 alpha-dihydrotestosterone analogues: characterization of a novel canine liver androgen-binding protein.
Molecular pharmacology 1995;47(5):1080-8.
1993: Jeffrey Toney; L Wu; A E Summerfield; G Sanyal; B M Forman; J Zhu; Herbert H Samuels
Conformational changes in chicken thyroid hormone receptor alpha 1 induced by binding to ligand or to DNA.
Biochemistry 1993;32(1):2-6.
1990: B A Donahue; M Augot; S F Bellon; D K Treiber; Jeffrey Toney; Stephen J Lippard; John M Essigmann
Characterization of a DNA damage-recognition protein from mammalian cells that binds specifically to intrastrand d(GpG) and d(ApG) DNA adducts of the anticancer drug cisplatin.
Biochemistry 1990;29(24):5872-80.
1989: Jeffrey Toney; B A Donahue; P J Kellett; S L Bruhn; John M Essigmann; Stephen J Lippard
Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II)
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8328-32.
1987: Paul W. Doetsch; W D Henner; R P Cunningham; Jeffrey Toney; D E Helland
A highly conserved endonuclease activity present in Escherichia coli, bovine, and human cells recognizes oxidative DNA damage at sites of pyrimidines.
Molecular and cellular biology 1987;7(1):26-32.
1985: Jeffrey Toney; M S Murthy; T J Marks
Biodistribution and pharmacokinetics of vanadium following intraperitoneal administration of vanadocene dichloride to mice.
Chemico-biological interactions 1985;56(1):45-54.
1983: K Seibert; S M Shafie; Timothy Triche; J J Whang-Peng; S J O'Brien; Jeffrey Toney; K K Huff; Marc Lippman
Clonal variation of MCF-7 breast cancer cells in vitro and in athymic nude mice.
Cancer research 1983;43(5):2223-39.
1983: Jeffrey Toney; J M Quirk
Computer assisted small-scale Tay-Sachs carrier screening.
Journal of applied biochemistry 1983;5(1-2):25-30.
1979: J W Kusiak; Jeffrey Toney; J M Quirk; R O Brady
Specific binding of 125I-labeled beta-hexosaminidase A to rat brain synaptosomes.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(2):982-5.