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giovanni gadda

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TOP 3
Crystal Smitherman; giovanni gadda
Evidence for a transient peroxynitro Acid in the reaction catalyzed by nitronate monooxygenase with propionate 3-nitronate.
Swathi Gannavaram; giovanni gadda
Relative timing of hydrogen and proton transfers in the reaction of flavin oxidation catalyzed by choline oxidase.
Kevin Francis; Shirley F Nishino; Jim C Spain; giovanni gadda
A novel activity for fungal nitronate monooxygenase: detoxification of the metabolic inhibitor propionate-3-nitronate.

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All Publications

2013: Crystal Smitherman; giovanni gadda
Evidence for a transient peroxynitro Acid in the reaction catalyzed by nitronate monooxygenase with propionate 3-nitronate.
Biochemistry 2013;52(15):2694-704.
2013: Swathi Gannavaram; giovanni gadda
Relative timing of hydrogen and proton transfers in the reaction of flavin oxidation catalyzed by choline oxidase.
Biochemistry 2013;52(7):1221-6.
2012: Kevin Francis; Shirley F Nishino; Jim C Spain; giovanni gadda
A novel activity for fungal nitronate monooxygenase: detoxification of the metabolic inhibitor propionate-3-nitronate.
Archives of biochemistry and biophysics 2012;521(1-2):84-9.
2012: giovanni gadda
Oxygen activation in flavoprotein oxidases: the importance of being positive.
Biochemistry 2012;51(13):2662-9.
2011: Hongling Yuan; Donald Hamelberg; Yao Xin; giovanni gadda
Insights on the mechanism of amine oxidation catalyzed by D-arginine dehydrogenase through pH and kinetic isotope effects.
Journal of the American Chemical Society 2011;133(46):18957-65.
2011: Shen Tang; Zhong-Min Wang; Hing-Cheung Wong; Osvaldo Delbono; giovanni gadda; Yun Huang; Andrea Pennati; You Zhuo; Jin Zou; Jenny J Yang
Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16265-70.
2011: Guoxing Fu; giovanni gadda; Siming Wang; Hongling Yuan; Irene T Weber
Atomic-resolution structure of an N5 flavin adduct in D-arginine dehydrogenase.
Biochemistry 2011;50(29):6292-4.
2011: Hongling Yuan; giovanni gadda
Importance of a serine proximal to the C(4a) and N(5) flavin atoms for hydride transfer in choline oxidase.
Biochemistry 2011;50(5):770-9.
2011: Andrea Pennati; giovanni gadda
Stabilization of an intermediate in the oxidative half-reaction of human liver glycolate oxidase.
Biochemistry 2011;50(1):1-3.
2010: Hongling Yuan; Guoxing Fu; Phillip T Brooks; Irene T Weber; giovanni gadda
Steady-state kinetic mechanism and reductive half-reaction of D-arginine dehydrogenase from Pseudomonas aeruginosa.
Biochemistry 2010;49(44):9542-50.
2010: Guoxing Fu; Hongling Yuan; Congran Li; Chung-Dar Lu; giovanni gadda; Irene T Weber
Conformational changes and substrate recognition in Pseudomonas aeruginosa D-arginine dehydrogenase.
Biochemistry 2010;49(39):8535-45.
2010: Steffan Finnegan; Hongling Yuan; Yuan-Fang Wang; Allen M Orville; Irene T Weber; giovanni gadda
Structural and kinetic studies on the Ser101Ala variant of choline oxidase: catalysis by compromise.
Archives of biochemistry and biophysics 2010;501(2):207-13.
2010: Osbourne Quaye; Tranbao Nguyen; Swathi Gannavaram; Andrea Pennati; giovanni gadda
Rescuing of the hydride transfer reaction in the Glu312Asp variant of choline oxidase by a substrate analogue.
Archives of biochemistry and biophysics 2010;499(1-2):1-5.
2010: Steffan Finnegan; Johnson Agniswamy; Irene T Weber; giovanni gadda
Role of valine 464 in the flavin oxidation reaction catalyzed by choline oxidase.
Biochemistry 2010;49(13):2952-61.
2010: Kunchala Rungsrisuriyachai; giovanni gadda
Role of asparagine 510 in the relative timing of substrate bond cleavages in the reaction catalyzed by choline oxidase.
Biochemistry 2010;49(11):2483-90.
2010: giovanni gadda
Guest editor's introduction. Special issue on oxidative enzymes.
Archives of biochemistry and biophysics 2010;493(1):1-2.
2010: giovanni gadda; Kevin Francis
Nitronate monooxygenase, a model for anionic flavin semiquinone intermediates in oxidative catalysis.
Archives of biochemistry and biophysics 2010;493(1):53-61.
2009: Andrea Pennati; giovanni gadda
Involvement of ionizable groups in catalysis of human liver glycolate oxidase.
The Journal of biological chemistry 2009;284(45):31214-22.
2009: Yao Xin; giovanni gadda; Donald Hamelberg
The cluster of hydrophobic residues controls the entrance to the active site of choline oxidase.
Biochemistry 2009;48(40):9599-605.
2009: Kevin Francis; giovanni gadda
Kinetic evidence for an anion binding pocket in the active site of nitronate monooxygenase.
Bioorganic chemistry 2009;37(5):167-72.
2009: Osbourne Quaye; giovanni gadda
Effect of a conservative mutation of an active site residue involved in substrate binding on the hydride tunneling reaction catalyzed by choline oxidase.
Archives of biochemistry and biophysics 2009;489(1-2):10-4.
2009: Osbourne Quaye; Sharonda Cowins; giovanni gadda
Contribution of flavin covalent linkage with histidine 99 to the reaction catalyzed by choline oxidase.
The Journal of biological chemistry 2009;284(25):16990-7.
2009: Ning Chen; Jin Zou; Siming Wang; Yiming Ye; Yun Huang; giovanni gadda; Jenny J Yang
Designing protease sensors for real-time imaging of trypsin activation in pancreatic cancer cells.
Biochemistry 2009;48(15):3519-26.
2009: Kevin Francis; giovanni gadda
Inflated kinetic isotope effects in the branched mechanism of Neurospora crassa 2-nitropropane dioxygenase.
Biochemistry 2009;48(11):2403-10.
2009: Kunchala Rungsrisuriyachai; giovanni gadda
A pH switch affects the steady-state kinetic mechanism of pyranose 2-oxidase from Trametes ochracea.
Archives of biochemistry and biophysics 2009;483(1):10-5.
2009: Allen M Orville; George T Lountos; Steffan Finnegan; giovanni gadda; Rajeev Prabhakar
Crystallographic, spectroscopic, and computational analysis of a flavin C4a-oxygen adduct in choline oxidase.
Biochemistry 2009;48(4):720-8.
2009: Michiya Kamio; Ko-Chun Ko; Shilong Zheng; Binghe Wang; Stacy L Collins; giovanni gadda; Phang-Cheng Tai; Charles D Derby
The chemistry of escapin: identification and quantification of the components in the complex mixture generated by an L-amino acid oxidase in the defensive secretion of the sea snail Aplysia californica.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(7):1597-603.
2008: Steffan Finnegan; giovanni gadda
Substitution of an active site valine uncovers a kinetically slow equilibrium between competent and incompetent forms of choline oxidase.
Biochemistry 2008;47(52):13850-61.
2008: giovanni gadda
Hydride transfer made easy in the reaction of alcohol oxidation catalyzed by flavin-dependent oxidases.
Biochemistry 2008;47(52):13745-53.
2008: Kevin Francis; giovanni gadda
The nonoxidative conversion of nitroethane to ethylnitronate in Neurospora crassa 2-nitropropane dioxygenase is catalyzed by histidine 196.
Biochemistry 2008;47(35):9136-44.
2008: Kunchala Rungsrisuriyachai; giovanni gadda
On the role of histidine 351 in the reaction of alcohol oxidation catalyzed by choline oxidase.
Biochemistry 2008;47(26):6762-9.
2008: Slavica Mijatovic; giovanni gadda
Oxidation of alkyl nitronates catalyzed by 2-nitropropane dioxygenase from Hansenula mrakii.
Archives of biochemistry and biophysics 2008;473(1):61-8.
2008: Andrea Pennati; Giuliana Zanetti; Alessandro Aliverti; giovanni gadda
Effect of salt and pH on the reductive half-reaction of Mycobacterium tuberculosis FprA with NADPH.
Biochemistry 2008;47(11):3418-25.
2008: Osbourne Quaye; George T Lountos; guijuan fan; Allen M Orville; giovanni gadda
Role of Glu312 in binding and positioning of the substrate for the hydride transfer reaction in choline oxidase.
Biochemistry 2008;47(1):243-56.
2007: Jin Zou; Aldebaran M Hofer; Monica M Lurtz; giovanni gadda; April L Ellis; Ning Chen; Yun Huang; Angela Holder; Yiming Ye; Charles F Louis; Kristy Welshhans; Vincent Rehder; Jenny J Yang
Developing sensors for real-time measurement of high Ca2+ concentrations.
Biochemistry 2007;46(43):12275-88.
2007: Arezou Zargari; C Selander; Omid Rasool; Mahmoud Ghanem; giovanni gadda; Reto Crameri; Annika Scheynius
Mala s 12 is a major allergen in patients with atopic eczema and has sequence similarities to the GMC oxidoreductase family.
Allergy 2007;62(6):695-703.
2007: guijuan fan; giovanni gadda
An internal equilibrium preorganizes the enzyme-substrate complex for hydride tunneling in choline oxidase.
Biochemistry 2007;46(21):6402-8.
2007: Jane V Hoang; giovanni gadda
Trapping choline oxidase in a nonfunctional conformation by freezing at low pH.
Proteins 2007;66(3):611-20.
2006: Kevin Francis; giovanni gadda
Probing the chemical steps of nitroalkane oxidation catalyzed by 2-nitropropane dioxygenase with solvent viscosity, pH, and substrate kinetic isotope effects.
Biochemistry 2006;45(46):13889-98.
2006: giovanni gadda; guijuan fan; Jane V Hoang
On the contribution of the positively charged headgroup of choline to substrate binding and catalysis in the reaction catalyzed by choline oxidase.
Archives of biochemistry and biophysics 2006;451(2):182-7.
2006: Mahmoud Ghanem; giovanni gadda
Effects of reversing the protein positive charge in the proximity of the flavin N(1) locus of choline oxidase.
Biochemistry 2006;45(10):3437-47.
2006: guijuan fan; Markus Germann; giovanni gadda
Mechanistic studies of choline oxidase with betaine aldehyde and its isosteric analogue 3,3-dimethylbutyraldehyde.
Biochemistry 2006;45(6):1979-86.
2005: guijuan fan; giovanni gadda
Oxygen- and temperature-dependent kinetic isotope effects in choline oxidase: correlating reversible hydride transfer with environmentally enhanced tunneling.
Journal of the American Chemical Society 2005;127(50):17954-61.
2005: guijuan fan; giovanni gadda
On the catalytic mechanism of choline oxidase.
Journal of the American Chemical Society 2005;127(7):2067-74.
2005: Kevin Francis; Bethany Russell; giovanni gadda
Involvement of a flavosemiquinone in the enzymatic oxidation of nitroalkanes catalyzed by 2-nitropropane dioxygenase.
The Journal of biological chemistry 2005;280(7):5195-204.
2005: Mahmoud Ghanem; giovanni gadda
On the catalytic role of the conserved active site residue His466 of choline oxidase.
Biochemistry 2005;44(3):893-904.
2004: giovanni gadda; Nichole L N Powell; Prashanthi Menon
The trimethylammonium headgroup of choline is a major determinant for substrate binding and specificity in choline oxidase.
Archives of biochemistry and biophysics 2004;430(2):264-73.
2004: guijuan fan; Mahmoud Ghanem; giovanni gadda
Cloning, sequence analysis, and purification of choline oxidase from Arthrobacter globiformis: a bacterial enzyme involved in osmotic stress tolerance.
Archives of biochemistry and biophysics 2004;421(1):149-58.
2003: Mahmoud Ghanem; guijuan fan; Kevin Francis; giovanni gadda
Spectroscopic and kinetic properties of recombinant choline oxidase from Arthrobacter globiformis.
Biochemistry 2003;42(51):15179-88.
2003: giovanni gadda
pH and deuterium kinetic isotope effects studies on the oxidation of choline to betaine-aldehyde catalyzed by choline oxidase.
Biochimica et biophysica acta 2003;1650(1-2):4-9.
2003: giovanni gadda; Elien Wilkins
Cloning, expression, and purification of choline dehydrogenase from the moderate halophile Halomonas elongata.
Applied and environmental microbiology 2003;69(4):2126-32.
2003: giovanni gadda
Kinetic mechanism of choline oxidase from Arthrobacter globiformis.
Biochimica et biophysica acta 2003;1646(1-2):112-8.
2002: Susan Colette Daubner; giovanni gadda; Michael P Valley; Paul F Fitzpatrick
Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2702-7.
2001: giovanni gadda; A Banerjee; G S Fleming; Paul F Fitzpatrick
Evidence for an essential arginine in the flavoprotein nitroalkane oxidase.
Journal of enzyme inhibition 2001;16(2):157-63.
2000: giovanni gadda; A Banerjee; Lawrence J Dangott; Paul F Fitzpatrick
Identification of a cysteine residue in the active site of nitroalkane oxidase by modification with N-ethylmaleimide.
The Journal of biological chemistry 2000;275(41):31891-5.
2000: giovanni gadda; D Y Choe; Paul F Fitzpatrick
Use of pH and kinetic isotope effects to dissect the effects of substrate size on binding and catalysis by nitroalkane oxidase.
Archives of biochemistry and biophysics 2000;382(1):138-44.
2000: giovanni gadda; Paul F Fitzpatrick
Mechanism of nitroalkane oxidase: 2. pH and kinetic isotope effects.
Biochemistry 2000;39(6):1406-10.
2000: giovanni gadda; Paul F Fitzpatrick
Iso-mechanism of nitroalkane oxidase: 1. Inhibition studies and activation by imidazole.
Biochemistry 2000;39(6):1400-5.
2000: giovanni gadda; A Banerjee; Paul F Fitzpatrick
Identification of an essential tyrosine residue in nitroalkane oxidase by modification with tetranitromethane.
Biochemistry 2000;39(5):1162-8.
1999: Loredano Pollegioni; giovanni gadda; D Ambrosius; Sandro Ghisla; Mirella S Pilone
Cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum: effect of surfactants and organic solvents on activity.
Biotechnology and applied biochemistry 1999;30 ( Pt 1)():27-33.
1999: giovanni gadda; Lawrence J Dangott; William H Johnson; Christian P Whitman; Paul F Fitzpatrick
Characterization of 2-oxo-3-pentynoate as an active-site-directed inactivator of flavoprotein oxidases: identification of active-site peptides in tryptophan 2-monooxygenase.
Biochemistry 1999;38(18):5822-8.
1999: giovanni gadda; Paul F Fitzpatrick
Substrate specificity of a nitroalkane-oxidizing enzyme.
Archives of biochemistry and biophysics 1999;363(2):309-13.
1998: giovanni gadda; Paul F Fitzpatrick
Biochemical and physical characterization of the active FAD-containing form of nitroalkane oxidase from Fusarium oxysporum.
Biochemistry 1998;37(17):6154-64.
1997: giovanni gadda; G Wels; Loredano Pollegioni; S Zucchelli; D Ambrosius; Mirella S Pilone; Sandro Ghisla
Characterization of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum.
European journal of biochemistry / FEBS 1997;250(2):369-76.
1997: giovanni gadda; RD Edmondson; David H Russell; Paul F Fitzpatrick
Identification of the naturally occurring flavin of nitroalkane oxidase from fusarium oxysporum as a 5-nitrobutyl-FAD and conversion of the enzyme to the active FAD-containing form.
The Journal of biological chemistry 1997;272(9):5563-70.
1995: giovanni gadda; G L Beretta; Mirella S Pilone
Reactivity of histidyl residues in D-amino acid oxidase from Rhodotorula gracilis.
FEBS letters 1995;363(3):307-10.
1994: giovanni gadda; G L Beretta; Mirella S Pilone
Chemical modification of lysyl residues of Rhodotorula gracilis D-amino acid oxidase.
Biochemistry and molecular biology international 1994;33(5):947-55.
1994: giovanni gadda; A Negri; Mirella S Pilone
Reaction of phenylglyoxal with arginine groups in D-amino-acid oxidase from Rhodotorula gracilis.
The Journal of biological chemistry 1994;269(27):17809-14.
1991: Alessandro Aliverti; giovanni gadda; Severino Ronchi; Giuliana Zanetti
Identification of Lys116 as the target of N-ethylmaleimide inactivation of ferredoxin:NADP+ oxidoreductase.
European journal of biochemistry / FEBS 1991;198(1):21-4.
1990: giovanni gadda; Alessandro Aliverti; Severino Ronchi; Giuliana Zanetti
Structure-function relationship in spinach ferredoxin-NADP+ reductase as studied by limited proteolysis.
The Journal of biological chemistry 1990;265(20):11955-9.