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Grace Patlewicz

Research Profile

Concepts & Ideas

Procedures

Anatomy

Skin

Disorders

Dermatitis, Allergic Contact

Chemicals & Drugs

Genes & Molecular Sequences

Molecular Structure

Activities & Behaviors

Computer Simulation

Living Beings

Mouse

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Co-author Network

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Publications

TOP 3
Grace Patlewicz; Richard D Phillips; J Craig Rowlands; Shawn D Seidel; Ted Simon; Katy Goyak; Richard A Becker
Use and validation of HT/HC assays to support 21st century toxicity evaluations.
Grace Patlewicz; David W Roberts; Aynur Aptula; Karen Blackburn; Bruno Hubesch
Workshop: use of "read-across" for chemical safety assessment under REACH.
Martin L Stephens; Douglas Wolf; Melvin Andersen; Richard A Becker; kellyn betts; Kim Boekelheide; Ed Carney; Robert Chapin; Dennis Devlin; Suzanne Fitzpatrick; John R Fowle; Patricia Harlow; Thomas Hartung; Sebastian Hoffmann; Michael Holsapple; Abigail Jacobs; Richard Judson; Olga Naidenko; Tim Pastoor; Grace Patlewicz; Andrew Rowan; Roberta Scherer; Rashid Shaikh; Ted Simon; Joanne Zurlo
Evidence-based toxicology for the 21st century: opportunities and challenges.

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All Publications

2013: Grace Patlewicz; Richard D Phillips; J Craig Rowlands; Shawn D Seidel; Ted Simon; Katy Goyak; Richard A Becker
Use and validation of HT/HC assays to support 21st century toxicity evaluations.
Regulatory toxicology and pharmacology : RTP 2013;65(2):259-68.
2013: Grace Patlewicz; David W Roberts; Aynur Aptula; Karen Blackburn; Bruno Hubesch
Workshop: use of "read-across" for chemical safety assessment under REACH.
Regulatory toxicology and pharmacology : RTP 2013;65(2):226-8.
2013: Martin L Stephens; Douglas Wolf; Melvin Andersen; Richard A Becker; kellyn betts; Kim Boekelheide; Ed Carney; Robert Chapin; Dennis Devlin; Suzanne Fitzpatrick; John R Fowle; Patricia Harlow; Thomas Hartung; Sebastian Hoffmann; Michael Holsapple; Abigail Jacobs; Richard Judson; Olga Naidenko; Tim Pastoor; Grace Patlewicz; Andrew Rowan; Roberta Scherer; Rashid Shaikh; Ted Simon; Joanne Zurlo
Evidence-based toxicology for the 21st century: opportunities and challenges.
ALTEX 2013;30(1):74-103.
2012: Ovanes G Mekenyan; Petko I Petkov; Stoyanka Stoeva; Romualdo Benigni; Sabcho D Dimitrov; E Maria Donner; Makoto Hayashi; Masamitsu Honma; Verginia B Kamenska; Stefan V Kotov; Grace Patlewicz
Investigating the relationship between in vitro-in vivo genotoxicity: derivation of mechanistic QSAR models for in vivo liver genotoxicity and in vivo bone marrow micronucleus formation which encompass metabolism.
Chemical research in toxicology 2012;25(2):277-96.
2011: David W Roberts; Aynur O Aptula; Grace Patlewicz
Chemistry-based risk assessment for skin sensitization: quantitative mechanistic modeling for the S(N)Ar domain.
Chemical research in toxicology 2011;24(7):1003-11.
2010: Ovanes Mekenyan; Grace Patlewicz; Stoyanka Stoeva; Milen Todorov; Gergana Dimitrova; Stefan Kotov; Chanita Kuseva; E Maria Donner
Use of genotoxicity information in the development of integrated testing strategies (ITS) for skin sensitization.
Chemical research in toxicology 2010;23(10):1519-40.
2010: David W Roberts; Grace Patlewicz
Updating the skin sensitization in vitro data assessment paradigm in 2009--a chemistry and QSAR perspective.
Journal of applied toxicology : JAT 2010;30(3):286-8; discussion 289.
2010: Humberto González Díaz; Fernanda Romaris; Aliuska Duardo-Sanchez; Lázaro G Pérez-Montoto; Francisco Prado-Prado; Grace Patlewicz; Florencio M Ubeira
Predicting drugs and proteins in parasite infections with topological indices of complex networks: theoretical backgrounds, applications, and legal issues.
Current pharmaceutical design 2010;16(24):2737-64.
2008: Ana Gallegos Saliner; Albert Poater; Nina Jeliazkova; Grace Patlewicz; Andrew P Worth
Toxmatch--a chemical classification and activity prediction tool based on similarity measures.
Regulatory toxicology and pharmacology : RTP 2008;52(2):77-84.
2008: Sebastian Hoffmann; Ana Gallegos Saliner; Grace Patlewicz; Chantra Eskes; Valerie Zuang; Andrew P Worth
A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals.
Toxicology letters 2008;180(1):9-20.
2008: David W Roberts; Aynur O Aptula; Grace Patlewicz; Camilla Pease
Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential.
Journal of applied toxicology : JAT 2008;28(4):443-54.
2008: Grace Patlewicz; David W Roberts; E Uriarte
A comparison of reactivity schemes for the prediction skin sensitization potential.
Chemical research in toxicology 2008;21(2):521-41.
2008: Grace Patlewicz; Nina Jeliazkova; R J Safford; A P Worth; B Aleksiev
An evaluation of the implementation of the Cramer classification scheme in the Toxtree software.
SAR and QSAR in environmental research 2008;19(5-6):495-524.
2007: David W Roberts; Grace Patlewicz; Sabcho D Dimitrov; Lawrence K Low; Aynur O Aptula; Petra S Kern; Gergana D Dimitrova; Mike I H Comber; Richard D Phillips; Jay Niemelä; Charlotte Madsen; Eva B Wedebye; Paul T Bailey; Ovanes Mekenyan
TIMES-SS--a mechanistic evaluation of an external validation study using reaction chemistry principles.
Chemical research in toxicology 2007;20(9):1321-30.
2007: Grace Patlewicz; Aynur O Aptula; E Uriarte; David W Roberts; Petra S Kern; G Frank Gerberick; Ian Kimber; Rebecca J Dearman; Cindy A Ryan; David A Basketter
An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential.
SAR and QSAR in environmental research 2007;18(5-6):515-41.
2007: David W Roberts; Grace Patlewicz; Petra S Kern; Frank Gerberick; Ian Kimber; Rebecca J Dearman; Cindy A Ryan; David A Basketter; Aynur O Aptula
Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization.
Chemical research in toxicology 2007;20(7):1019-30.
2007: Grace Patlewicz; Sabcho D Dimitrov; Lawrence K Low; Petra S Kern; Gergana D Dimitrova; Mike I H Comber; Aynur O Aptula; Richard D Phillips; Jay Niemelä; Charlotte Madsen; Eva B Wedebye; David W Roberts; Paul T Bailey; Ovanes Mekenyan
TIMES-SS--a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity.
Regulatory toxicology and pharmacology : RTP 2007;48(2):225-39.
2007: David W Roberts; Aynur O Aptula; Mark T D Cronin; E Hulzebos; Grace Patlewicz
Global (Q)SARs for skin sensitisation: assessment against OECD principles.
SAR and QSAR in environmental research 2007;18(3-4):343-65.
2007: A Gallegos Saliner; Ivanka Tsakovska; Manuela Pavan; Grace Patlewicz; Andrew P Worth
Evaluation of SARs for the prediction of skin irritation/corrosion potential: structural inclusion rules in the BfR decision support system.
SAR and QSAR in environmental research 2007;18(3-4):331-42.
2007: David A Basketter; Camilla K Pease; Gerald Kasting; Ian Kimber; Silvia Casati; Mark Cronin; Walter Diembeck; Frank Gerberick; Jonathan Hadgraft; Thomas Hartung; Jean-Paul Marty; Efstathios Nikolaidis; Grace Patlewicz; David Roberts; Erwin Roggen; Costanza Rovida; Johannes J M van de Sandt
Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59.
Alternatives to laboratory animals : ATLA 2007;35(1):137-54.
2007: Andrew P Worth; A Bassan; J De Bruijn; Ana Gallegos Saliner; Tatiana I Netzeva; Grace Patlewicz; Manuela Pavan; Ivanka Tsakovska; S Eisenreich
The role of the European Chemicals Bureau in promoting the regulatory use of (Q)SAR methods.
SAR and QSAR in environmental research 2007;18(1-2):111-25.
2007: David W Roberts; Aynur O Aptula; Grace Patlewicz
Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay.
Chemical research in toxicology 2007;20(1):44-60.
2006: Kate Langton; Grace Patlewicz; Anthony Long; Carol A Marchant; David A Basketter
Structure-activity relationships for skin sensitization: recent improvements to Derek for Windows.
Contact dermatitis 2006;55(6):342-7.
2006: David W Roberts; Aynur O Aptula; Grace Patlewicz
Mechanistic applicability domains for non-animal based prediction of toxicological endpoints. QSAR analysis of the schiff base applicability domain for skin sensitization.
Chemical research in toxicology 2006;19(9):1228-33.
2006: Marjan Vracko; V Bandelj; Pierluigi Barbieri; Emilio Benfenati; Q Chaudhry; M Cronin; J Devillers; A Gallegos; Giuseppina Gini; Paola Gramatica; Christoph Helma; Paolo Mazzatorta; D Neagu; Tatiana I Netzeva; Manuela Pavan; Grace Patlewicz; M Randić; Ivanka Tsakovska; Andrew P Worth
Validation of counter propagation neural network models for predictive toxicology according to the OECD principles: a case study.
SAR and QSAR in environmental research 2006;17(3):265-84.
2006: Ian Kimber; Rebecca J Dearman; Catherine J Betts; G Frank Gerberick; Cindy A Ryan; Petra S Kern; Grace Patlewicz; David A Basketter
The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements?
Contact dermatitis 2006;54(4):181-5.
2006: Aynur O Aptula; Grace Patlewicz; David W Roberts; T Wayne Schultz
Non-enzymatic glutathione reactivity and in vitro toxicity: a non-animal approach to skin sensitization.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(2):239-47.
2005: G Frank Gerberick; Cindy A Ryan; Petra S Kern; Harald Schlatter; Rebecca J Dearman; Ian Kimber; Grace Patlewicz; David A Basketter
Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods.
Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group 2005;16(4):157-202.
2005: Aynur O Aptula; Grace Patlewicz; David W Roberts
Skin sensitization: reaction mechanistic applicability domains for structure-activity relationships.
Chemical research in toxicology 2005;18(9):1420-6.
2005: Sabcho D Dimitrov; Lawrence K Low; Grace Patlewicz; Petra S Kern; Gergana D Dimitrova; Mike H I Comber; Richard D Phillips; Jay Niemela; Paul T Bailey; Ovanes Mekenyan
Skin sensitization: modeling based on skin metabolism simulation and formation of protein conjugates.
International journal of toxicology 2005;24(4):189-204.
2005: Sabcho D Dimitrov; Gergana D Dimitrova; Todor Pavlov; Nadezhda Dimitrova; Grace Patlewicz; Jay Niemela; Ovanes Mekenyan
A stepwise approach for defining the applicability domain of SAR and QSAR models.
Journal of chemical information and modeling 2005;45(4):839-49.
2005: Tatiana I Netzeva; Andrew P Worth; Tom Aldenberg; Romualdo Benigni; Mark T D Cronin; Paola Gramatica; Joanna Jaworska; Scott Kahn; Gilles Klopman; Carol A Marchant; Glenn Myatt; Nina Jeliazkova; Grace Patlewicz; Roger Perkins; David Roberts; Terry Schultz; David W Stanton; Johannes J M van de Sandt; Weida Tong; Gilman Veith; Chihae Yang
Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52.
Alternatives to laboratory animals : ATLA 2005;33(2):155-73.
2004: Heidi Søsted; David A Basketter; E Estrada; Jeanne Duus Johansen; Grace Patlewicz
Ranking of hair dye substances according to predicted sensitization potency: quantitative structure-activity relationships.
Contact dermatitis 2004;51(5-6):241-54.
2004: G Frank Gerberick; Cindy A Ryan; Petra S Kern; Rebecca J Dearman; Ian Kimber; Grace Patlewicz; David A Basketter
A chemical dataset for evaluation of alternative approaches to skin-sensitization testing.
Contact dermatitis 2004;50(5):274-88.
2004: Ernesto Estrada; Grace Patlewicz; Yaquelin Gutierrez
From knowledge generation to knowledge archive. A general strategy using TOPS-MODE with DEREK to formulate new alerts for skin sensitization.
Journal of chemical information and computer sciences 2004;44(2):688-98.
2004: Grace Patlewicz; David A Basketter; Camilla K Pease; Karen Wilson; Zoë M Wright; David W Roberts; Guillaume Bernard; Elena Giménez Arnau; Jean-Pierre Lepoittevin
Further evaluation of quantitative structure--activity relationship models for the prediction of the skin sensitization potency of selected fragrance allergens.
Contact dermatitis 2004;50(2):91-7.
2004: Ernesto Estrada; Jose A Quincoces; Grace Patlewicz
Creating molecular diversity from antioxidants in Brazilian propolis. Combination of TOPS-MODE QSAR and virtual structure generation.
Molecular diversity 2004;8(1):21-33.
2003: Ernesto Estrada; Grace Patlewicz; Mark Chamberlain; David A Basketter; Sue Larbey
Computer-aided knowledge generation for understanding skin sensitization mechanisms: the TOPS-MODE approach.
Chemical research in toxicology 2003;16(10):1226-35.
2003: Grace Patlewicz; Rosemary Rodford; John D Walker
Quantitative structure-activity relationships for predicting mutagenicity and carcinogenicity.
Environmental toxicology and chemistry / SETAC 2003;22(8):1885-93.
2003: John D Walker; Rosemary Rodford; Grace Patlewicz
Quantitative structure-activity relationships for predicting percutaneous absorption rates.
Environmental toxicology and chemistry / SETAC 2003;22(8):1870-84.
2003: Grace Patlewicz; Rosemary Rodford; John D Walker
Quantitative structure-activity relationships for predicting skin and eye irritation.
Environmental toxicology and chemistry / SETAC 2003;22(8):1862-9.
2003: Rosemary Rodford; Grace Patlewicz; John D Walker; Martin P Payne
Quantitative structure-activity relationships for predicting skin and respiratory sensitization.
Environmental toxicology and chemistry / SETAC 2003;22(8):1855-61.
2003: David A Basketter; C K Smith Pease; Grace Patlewicz
Contact allergy: the local lymph node assay for the prediction of hazard and risk.
Clinical and experimental dermatology 2003;28(2):218-21.
2003: C K Smith Pease; David A Basketter; Grace Patlewicz
Contact allergy: the role of skin chemistry and metabolism.
Clinical and experimental dermatology 2003;28(2):177-83.
2002: Grace Patlewicz; Zoë M Wright; David A Basketter; Camilla K Pease; Jean-Pierre Lepoittevin; Elena Giménez Arnau
Structure-activity relationships for selected fragrance allergens.
Contact dermatitis 2002;47(4):219-26.
2002: David A Basketter; Zoë M Wright; Neil R Colson; Grace Patlewicz; Camilla K Pease
Investigation of the skin sensitizing activity of linalool.
Contact dermatitis 2002;47(3):161-4.

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