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Sharon Bryant
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60
Lazarus, Lawrence
39
Salvadori, Severo
27
Jinsmaa, Yunden
27
Balboni, Gianfranco
21
Guerrini, Remo
20
Okada, Yoshio
18
Ambo, Akihiro
18
Tsuda, Yuko
16
Li, Tingyou
13
Miyazaki, Anna
13
Sasaki, Yusuke
11
Shiotani, Kimitaka
8
Yokoi, Toshio
8
Negri, Lucia
8
Fujita, Yoshio
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Geonetwork of Sharon Bryant (preview)
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All Publications
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2007: Shiotani Kimitaka; Miyazaki Anna; Li Tingyou; Tsuda Yuko; Yokoi Toshio; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Okada Yoshio
Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH(2))(m)]-6-[H-Dmt-NH(CH(2))(n)]-2(1H)-pyrazinones, and studies on structure-activity relationships.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2007;3(6):583-98.
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2007: Salvadori Severo; Trapella Claudio; Fiorini Stella; Negri Lucia; Lattanzi Roberta; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Balboni Gianfranco
A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.
Bioorganic & medicinal chemistry 2007;15(22):6876-81.
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2007: Shiotani Kimitaka; Li Tingyou; Miyazaki Anna; Tsuda Yuko; Yokoi Toshio; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.
Bioorganic & medicinal chemistry letters 2007;17(21):5768-71.
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2007: Marczak Ewa D; Jinsmaa Yunden; Li Tingyou; Bryant Sharon D; Tsuda Yuko; Okada Yoshio; Lazarus Lawrence H
[N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties.
The Journal of pharmacology and experimental therapeutics 2007;323(1):374-80.
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2007: Li Tingyou; Shiotani Kimitaka; Miyazaki Anna; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Jinsmaa Yunden; Marczak Ewa; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.
Journal of medicinal chemistry 2007;50(12):2753-66.
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2007: Balboni Gianfranco; Onnis Valentina; Congiu Cenzo; Zotti Margherita; Sasaki Yusuke; Ambo Akihiro; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Lazzari Ilaria; Trapella Claudio; Salvadori Severo
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.
Bioorganic & medicinal chemistry 2007;15(9):3143-51.
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2007: Li Tingyou; Jinsmaa Yunden; Nedachi Masahiro; Miyazaki Anna; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Marczak Ewa; Li Qiang; Swartzwelder H Scott; Lazarus Lawrence H; Okada Yoshio
Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.
Bioorganic & medicinal chemistry 2007;15(3):1237-51.
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2006: Shiotani Kimitaka; Li Tingyou; Miyazaki Anna; Tsuda Yuko; Bryant Sharon D; Ambo Akihiro; Sasaki Yusuke; Lazarus Lawrence H; Okada Yoshio
Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.
Bioorganic & medicinal chemistry letters 2006;16(22):5793-6.
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2006: Balboni Gianfranco; Onnis Valentina; Congiu Cenzo; Zotti Margherita; Sasaki Yusuke; Ambo Akihiro; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Trapella Claudio; Salvadori Severo
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Journal of medicinal chemistry 2006;49(18):5610-7.
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2006: Ballet Steven; Salvadori Severo; Trapella Claudio; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Negri Lucia; Giannini Elisa; Lattanzi Roberta; Tourwé Dirk; Balboni Gianfranco
New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Journal of medicinal chemistry 2006;49(13):3990-3.
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2006: Jinsmaa Yunden; Marczak Ewa; Fujita Yoshio; Shiotani Kimitaka; Miyazaki Anna; Li Tingyou; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Okada Yoshio; Lazarus Lawrence H
Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1.
Pharmacology, biochemistry, and behavior 2006;84(2):252-8.
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2006: Vázquez M Eugenio; Blanco Juan B; Salvadori Severo; Trapella Claudio; Argazzi Roberto; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H; Negri Lucia; Giannini Elisa; Lattanzi Roberta; Colucci Mariantonella; Balboni Gianfranco
6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.
Journal of medicinal chemistry 2006;49(12):3653-8.
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2005: Balboni Gianfranco; Guerrini Remo; Salvadori Severo; Negri Lucia; Giannini Elisa; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
Journal of medicinal chemistry 2005;48(26):8112-4.
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2005: Li Tingyou; Fujita Yoshio; Shiotani Kimitaka; Miyazaki Anna; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Jinsmaa Yunden; Marczak Ewa; Bryant Sharon D; Salvadori Severo; Lazarus Lawrence H; Okada Yoshio
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.
Journal of medicinal chemistry 2005;48(25):8035-44.
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2005: Li Tingyou; Shiotani Kimitaka; Miyazaki Anna; Fujita Yoshio; Tsuda Yuko; Ambo Akihiro; Sasaki Yusuke; Jinsmaa Yunden; Marczak Ewa; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.
Bioorganic & medicinal chemistry letters 2005;15(24):5517-20.
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2005: Miyazaki Anna; Fujisawa Yutaka; Shiotani Kimitaka; Fujita Yoshio; Li Tingyou; Tsuda Yuko; Yokoi Toshio; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Studies on the mechanism of 1,2-dihydropyrazin-2-one ring formation from dipeptidyl chloromethyl ketone and its chemical properties: immediate deamination during catalytic hydrogenation.
Chemical & pharmaceutical bulletin 2005;53(9):1152-8.
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2005: Balboni Gianfranco; Cocco Maria Teresa; Salvadori Severo; Romagnoli Romeo; Sasaki Yusuke; Okada Yoshio; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.
Journal of medicinal chemistry 2005;48(17):5608-11.
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2005: Jinsmaa Yunden; Fujita Yoshio; Shiotani Kimitaka; Miyazaki Anna; Li Tingyou; Tsuda Yuko; Okada Yoshio; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Lazarus Lawrence H
Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse.
European journal of pharmacology 2005;509(1):37-42.
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2005: Fujita Yoshio; Tsuda Yuko; Motoyama Takashi; Li Tingyou; Miyazaki Anna; Yokoi Toshio; Sasaki Yusuke; Ambo Akihiro; Niizuma Hideko; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).
Bioorganic & medicinal chemistry letters 2005;15(3):599-602.
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2005: Li Tingyou; Fujita Yoshio; Tsuda Yuko; Miyazaki Anna; Ambo Akihiro; Sasaki Yusuke; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.
Journal of medicinal chemistry 2005;48(2):586-92.
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2004: Balboni Gianfranco; Salvadori Severo; Dal Piaz Alessandro; Bortolotti Fabrizio; Argazzi Roberto; Negri Lucia; Lattanzi Roberta; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.
Journal of medicinal chemistry 2004;47(26):6541-6.
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2004: Balboni Gianfranco; Salvadori Severo; Guerrini Remo; Negri Lucia; Giannini Elisa; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.
Journal of medicinal chemistry 2004;47(16):4066-71.
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2004: Fujita Yoshio; Tsuda Yuko; Li Tingyou; Motoyama Takashi; Takahashi Motohiro; Shimizu Yoshiro; Yokoi Toshio; Sasaki Yusuke; Ambo Akihiro; Kita Atsuko; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.
Journal of medicinal chemistry 2004;47(14):3591-9.
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2004: Jinsmaa Yunden; Miyazaki Anna; Fujita Yoshio; Li Tingyou; Fujisawa Yutaka; Shiotani Kimitaka; Tsuda Yuko; Yokoi Toshio; Ambo Akihiro; Sasaki Yusuke; Bryant Sharon D; Lazarus Lawrence H; Okada Yoshio
Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.
Journal of medicinal chemistry 2004;47(10):2599-610.
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2004: Jinsmaa Yunden; Okada Yoshio; Tsuda Yuko; Shiotani Kimitaka; Sasaki Yusuke; Ambo Akihiro; Bryant Sharon D; Lazarus Lawrence H
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
The Journal of pharmacology and experimental therapeutics 2004;309(1):432-8.
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2003: Balboni Gianfranco; Salvadori Severo; Guerrini Remo; Negri Lucia; Giannini Elisa; Bryant Sharon D; Jinsmaa Yunden; Lazarus Lawrence H
Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism.
Bioorganic & medicinal chemistry 2003;11(24):5435-41.
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2003: Okada Yoshio; Tsuda Yuko; Fujita Yoshio; Yokoi Toshio; Sasaki Yusuke; Ambo Akihiro; Konishi Ryoji; Nagata Mitsuhiro; Salvadori Severo; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H
Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.
Journal of medicinal chemistry 2003;46(15):3201-9.
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2003: Okada Yoshio; Fujita Yoshio; Motoyama Takashi; Tsuda Yuko; Yokoi Toshio; Li Tingyou; Sasaki Yusuke; Ambo Akihiro; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H
Structural studies of [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond.
Bioorganic & medicinal chemistry 2003;11(9):1983-94.
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2003: Bryant Sharon D; Jinsmaa Yunden; Salvadori Severo; Okada Yoshio; Lazarus Lawrence H
Dmt and opioid peptides: a potent alliance.
Biopolymers 2003;71(2):86-102.
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2002: Balboni Gianfranco; Salvadori Severo; Guerrini Remo; Negri Lucia; Giannini Elisa; Jinsmaa Yunden; Bryant Sharon D; Lazarus Lawrence H
Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2002;45(25):5556-63.
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2002: Bryant Sharon D; George Clifford; Flippen-Anderson Judith L; Deschamps Jeffrey R; Salvadori Severo; Balboni Gianfranco; Guerrini Remo; Lazarus Lawrence H
Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2002;45(25):5506-13.
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2002: Balboni Gianfranco; Guerrini Remo; Salvadori Severo; Bianchi Clementina; Rizzi Daniela; Bryant Sharon D; Lazarus Lawrence H
Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
Journal of medicinal chemistry 2002;45(3):713-20.
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2002: Okada Yoshio; Tsuda Yuko; Bryant Sharon D; Lazarus Lawrence H
Endomorphins and related opioid peptides.
Vitamins and hormones 2002;65():257-79.
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2001: Lovekamp T; Cooper P S; Hardison J; Bryant S D; Guerrini R; Balboni G; Salvadori S; Lazarus L H
Inhibition of human multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist.
Brain research 2001;902(1):131-4.
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2000: Santagada V; Balboni G; Caliendo G; Guerrini R; Salvadori S; Bianchi C; Bryant S D; Lazarus L H
Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.
Bioorganic & medicinal chemistry letters 2000;10(24):2745-8.
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2000: Balboni G; Salvadori S; Guerrini R; Bianchi C; Santagada V; Calliendo G; Bryant S D; Lazarus L H
Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei.
Peptides 2000;21(11):1663-71.
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2000: Labarre M; Butterworth J; St-Onge S; Payza K; Schmidhammer H; Salvadori S; Balboni G; Guerrini R; Bryant S D; Lazarus L H
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.
European journal of pharmacology 2000;406(1):R1-3.
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2000: Okada Y; Fukumizu A; Takahashi M; Shimizu Y; Tsuda Y; Yokoi T; Bryant S D; Lazarus L H
Synthesis of stereoisomeric analogues of endomorphin-2, H-Tyr-Pro-Phe-Phe-NH(2), and examination of their opioid receptor binding activities and solution conformation.
Biochemical and biophysical research communications 2000;276(1):7-11.
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2000: Monory K; Bryant S D; Kertész I; Balboni G; Guerrini R; Tóth G; Salvadori S; Lazarus L H; Borsodi A
Characterization of N,N(Me)2-Dmt-Tic-OH, a delta selective opioid dipeptide antagonist.
Neuroreport 2000;11(10):2083-6.
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1999: Salvadori S; Guerrini R; Balboni G; Bianchi C; Bryant S D; Cooper P S; Lazarus L H
Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.
Journal of medicinal chemistry 1999;42(24):5010-9.
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1999: Okada Y; Fukumizu A; Takahashi M; Yokoi T; Tsuda Y; Bryant S D; Lazarus L H
Synthesis of pyrazinone ring-containing opioid mimetics and examination of their opioid receptor-binding activity.
Chemical & pharmaceutical bulletin 1999;47(8):1193-5.
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1999: Lazarus L H; Bryant S D; Cooper P S; Salvadori S
What peptides these deltorphins be.
Progress in neurobiology 1999;57(4):377-420.
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1998: Okada Y; Tsukatani M; Taguchi H; Yokoi T; Bryant S D; Lazarus L H
Amino acids and peptides. LII. Design and synthesis of opioid mimetics containing a pyrazinone ring and examination of their opioid receptor binding activity.
Chemical & pharmaceutical bulletin 1998;46(9):1374-82.
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1998: Bryant S D; Salvadori S; Cooper P S; Lazarus L H
New delta-opioid antagonists as pharmacological probes.
Trends in pharmacological sciences 1998;19(2):42-6.
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1998: Guerrini R; Capasso A; Marastoni M; Bryant S D; Cooper P S; Lazarus L H; Temussi P A; Salvadori S
Rational design of dynorphin A analogues with delta-receptor selectivity and antagonism for delta- and kappa-receptors.
Bioorganic & medicinal chemistry 1998;6(1):57-62.
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1997: Salvadori S; Balboni G; Guerrini R; Tomatis R; Bianchi C; Bryant S D; Cooper P S; Lazarus L H
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Journal of medicinal chemistry 1997;40(19):3100-8.
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1997: Bryant S D; Guerrini R; Salvadori S; Bianchi C; Tomatis R; Attila M; Lazarus L H
Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
Journal of medicinal chemistry 1997;40(16):2579-87.
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1997: Bryant S D; Balboni G; Guerrini R; Salvadori S; Tomatis R; Lazarus L H
Opioid diketopiperazines: refinement of the delta opioid antagonist pharmacophore.
Biological chemistry 1997;378(2):107-14.
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1997: Balboni G; Guerrini R; Salvadori S; Tomatis R; Bryant S D; Bianchi C; Attila M; Lazarus L H
Opioid diketopiperazines: synthesis and activity of a prototypic class of opioid antagonists.
Biological chemistry 1997;378(1):19-29.
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1996: Guerrini R; Capasso A; Sorrentino L; Anacardio R; Bryant S D; Lazarus L H; Attila M; Salvadori S
Opioid receptor selectivity alteration by single residue replacement: synthesis and activity profile of [Dmt1]deltorphin B.
European journal of pharmacology 1996;302(1-3):37-42.
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1996: Breveglieri A; Guerrini R; Salvadori S; Bianchi C; Bryant S D; Attila M; Lazarus L H
Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.
Journal of medicinal chemistry 1996;39(3):773-80.
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1996: Lazarus L H; Bryant S D; Salvadori S; Attila M; Sargent Jones L
Opioid infidelity: novel opioid peptides with dual high affinity for delta- and mu-receptors.
Trends in neurosciences 1996;19(1):31-5.
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1996: Capasso A; Guerrini R; Balboni G; Sorrentino L; Temussi P; Lazarus L H; Bryant S D; Salvadori S
Dmt-Tic-OH a highly selective and potent delta-opioid dipeptide receptor antagonist after systemic administration in the mouse.
Life sciences 1996;59(8):PL93-8.
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1995: Salvadori S; Attila M; Balboni G; Bianchi C; Bryant S D; Crescenzi O; Guerrini R; Picone D; Tancredi T; Temussi P A
Delta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.
Molecular medicine (Cambridge, Mass.) 1995;1(6):678-89.
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1995: Balboni G; Salvadori S; D'Angeli F; Marchetti P; Lazarus L H; Bryant S D; Bianchi C
Single diastereomeric desaminotyrosylalanyl tetra- and heptapeptides with opioid antagonistic activity.
International journal of peptide and protein research 1995;45(2):187-93.
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1994: Tancredi T; Salvadori S; Amodeo P; Picone D; Lazarus L H; Bryant S D; Guerrini R; Marzola G; Temussi P A
Conversion of enkephalin and dermorphin into delta-selective opioid antagonists by single-residue substitution.
European journal of biochemistry / FEBS 1994;224(1):241-7.
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1994: Lazarus L H; Bryant S D; Attila M; Salvadori S
Frog skin opioid peptides: a case for environmental mimicry.
Environmental health perspectives 1994;102(8):648-54.
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1994: Bryant S D; Attila M; Salvadori S; Guerrini R; Lazarus L H
Molecular dynamics conformations of deltorphin analogues advocate delta opioid binding site models.
Peptide research 1994;7(4):175-84.
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1993: Attila M; Salvadori S; Balboni G; Bryant S D; Lazarus L H
Synthesis and receptor binding analysis of dermorphin hepta-, hexa- and pentapeptide analogues. Evidence for one- and two-side binding models for the mu-opioid receptor.
International journal of peptide and protein research 1993;42(6):550-9.
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1993: Salvadori S; Bryant S D; Bianchi C; Balboni G; Scaranari V; Attila M; Lazarus L H
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
Journal of medicinal chemistry 1993;36(24):3748-56.
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1993: Salvadori S; Bryant S D; Temussi P A; Bundy D M; Attila M; Tomatis R; Lazarus L H
Relationship between receptor affinity and topography of N-terminally extended and bridged [Tyr1-->Asp4]deltorphin C analogues: novel probes for the delta-opioid receptor.
European journal of pharmacology 1993;230(3):357-61.
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