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Robert Raffa

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S Cangoz; Y-Y Chang; S J Chempakaseril; R C Guduru; L M Huynh; J S John; S T John; M E Joseph; R Judge; R Kimmey; K Kudratov; P J Lee; I C Madhani; C Ruchalski; P J Shim; S Singh; S Singh; Robert Raffa
Vitamin D and type 2 diabetes mellitus.
Robert Raffa; N S Eltoukhy; Kenneth F Raffa
Implications of climate change (global warming) for the healthcare system.
Robert Raffa; S J Ward
CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).

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2013: S Cangoz; Y-Y Chang; S J Chempakaseril; R C Guduru; L M Huynh; J S John; S T John; M E Joseph; R Judge; R Kimmey; K Kudratov; P J Lee; I C Madhani; C Ruchalski; P J Shim; S Singh; S Singh; Robert Raffa
Vitamin D and type 2 diabetes mellitus.
Journal of clinical pharmacy and therapeutics 2013;38(2):81-4.
2012: Robert Raffa; N S Eltoukhy; Kenneth F Raffa
Implications of climate change (global warming) for the healthcare system.
Journal of clinical pharmacy and therapeutics 2012;37(5):502-4.
2012: Robert Raffa; S J Ward
CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).
Journal of clinical pharmacy and therapeutics 2012;37(3):260-5.
2012: L Ramoz; P Bhatt; S Lodi; Robert Raffa; A B Reitz; C Tallarida; Ronald J Tallarida; Scott M Rawls
Mephedrone ("bath salt") pharmacology: insights from invertebrates.
Neuroscience 2012;208():79-84.
2012: K Akter; D A Gallo; S A Martin; N Myronyuk; R T Roberts; K Stercula; Robert Raffa
A review of the possible role of the essential fatty acids and fish oils in the aetiology, prevention or pharmacotherapy of schizophrenia.
Journal of clinical pharmacy and therapeutics 2012;37(2):132-9.
2012: Robert Raffa; Joseph Pergolizzi
Multi-mechanistic analgesia for opioid-induced hyperalgesia.
Journal of clinical pharmacy and therapeutics 2012;37(2):125-7.
2012: Robert Raffa; Joseph Pergolizzi
The evolving understanding of the analgesic mechanism of action of flupirtine.
Journal of clinical pharmacy and therapeutics 2012;37(1):4-6.
2011: Robert Raffa
Cancer 'survivor-care': I. the α7 nAChR as potential target for chemotherapy-related cognitive impairment.
Journal of clinical pharmacy and therapeutics 2011;36(4):437-45.
2011: Robert Raffa; Joseph Pergolizzi
Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example.
Journal of clinical pharmacy and therapeutics 2011;36(3):283-98.
2011: Robert Raffa
A proposed mechanism for chemotherapy-related cognitive impairment ('chemo-fog').
Journal of clinical pharmacy and therapeutics 2011;36(3):257-9.
2010: K Toussaint; X C Yang; M A Zielinski; K L Reigle; S D Sacavage; Swati Nagar; Robert Raffa
What do we (not) know about how paracetamol (acetaminophen) works?
Journal of clinical pharmacy and therapeutics 2010;35(6):617-38.
2010: Scott M Rawls; F Karaca; I Madhani; V Bhojani; R L Martinez; M Abou-Gharbia; Robert Raffa
β-lactamase inhibitors display anti-seizure properties in an invertebrate assay.
Neuroscience 2010;169(4):1800-4.
2010: Scott M Rawls; Tavni Patil; Ekaternia Yuvasheva; Robert Raffa
First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians.
Behavioural pharmacology 2010;21(4):301-13.
2010: Robert Raffa; R J Tallarida
Effects on the visual system might contribute to some of the cognitive deficits of cancer chemotherapy-induced 'chemo-fog'.
Journal of clinical pharmacy and therapeutics 2010;35(3):249-55.
2010: Robert Raffa; Joseph Pergolizzi; D J Segarnick; R J Tallarida
Oxycodone combinations for pain relief.
Drugs of today (Barcelona, Spain : 1998) 2010;46(6):379-98.
2010: Robert Raffa
Is a picture worth a thousand (forgotten) words?: neuroimaging evidence for the cognitive deficits in 'chemo-fog'/'chemo-brain'.
Journal of clinical pharmacy and therapeutics 2010;35(1):1-9.
2009: Robert Raffa
The M5 muscarinic receptor as possible target for treatment of drug abuse.
Journal of clinical pharmacy and therapeutics 2009;34(6):623-9.
2009: L I Varga; N Ako-Agugua; J Colasante; L Hertweck; T Houser; J Smith; A A Watty; Swati Nagar; Robert Raffa
Critical review of ropinirole and pramipexole - putative dopamine D(3)-receptor selective agonists - for the treatment of RLS.
Journal of clinical pharmacy and therapeutics 2009;34(5):493-505.
2009: Scott M Rawls; Timmy Thomas; Mobilaji Adeola; Tanvi Patil; Natalie Raymondi; Asha Poles; Michael Loo; Robert Raffa
Topiramate antagonizes NMDA- and AMPA-induced seizure-like activity in planarians.
Pharmacology, biochemistry, and behavior 2009;93(4):363-7.
2009: H Dhami; C E Fritz; B Gankin; S H Pak; W Yi; M-J Seya; Robert Raffa; Swati Nagar
The chemokine system and CCR5 antagonists: potential in HIV treatment and other novel therapies.
Journal of clinical pharmacy and therapeutics 2009;34(2):147-60.
2008: Steve Sacavage; Hiren Patel; Mike Zielinski; Jeneane Acker; Austin G Phillips; Robert Raffa; Scott M Rawls
Withdrawal-like behavior in planarians is dependent on drug exposure duration.
Neuroscience letters 2008;439(1):84-8.
2008: Scott M Rawls; Steven Baron; Zhe Ding; Christopher Roth; Nurulain Zaveri; Robert Raffa
Nociceptin attenuates methamphetamine abstinence-induced withdrawal-like behavior in planarians.
Neuropeptides 2008;42(3):229-37.
2008: Martilias S Farrell; Kirsti Gilmore; Robert Raffa; Ellen A Walker
Behavioral characterization of serotonergic activation in the flatworm Planaria.
Behavioural pharmacology 2008;19(3):177-82.
2008: Robert Raffa; Dennis J Stone
Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice.
The Journal of pharmacology and experimental therapeutics 2008;325(2):500-6.
2008: Scott M Rawls; Federica Cavallo; Anna Capasso; Zhe Ding; Robert Raffa
The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, and clorazepate in planarians.
European journal of pharmacology 2008;584(2-3):278-84.
2008: Robert Raffa
Basic pharmacology relevant to drug abuse assessment: tramadol as example.
Journal of clinical pharmacy and therapeutics 2008;33(2):101-8.
2008: Robert Raffa; Gregory W Stagliano; Geoffrey Ross; Jenay A Powell; Austin G Phillips; Zhe Ding; Scott M Rawls
The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'.
Brain research 2008;1193():51-6.
2008: Esin Kadiev; Vipul Patel; Pouya Rad; Lovely Thankachan; Abby Tram; Meg Weinlein; Kristin Woodfin; Robert Raffa; Swati Nagar
Role of pharmacogenetics in variable response to drugs: focus on opioids.
Expert opinion on drug metabolism & toxicology 2008;4(1):77-91.
2007: Scott M Rawls; Teresa Gomez; Zhe Ding; Robert Raffa
Differential behavioral effect of the TRPM8/TRPA1 channel agonist icilin (AG-3-5).
European journal of pharmacology 2007;575(1-3):103-4.
2007: Robert Raffa; Federica Cavallo; Anna Capasso
Flumazenil-sensitive dose-related physical dependence in planarians produced by two benzodiazepine and one non-benzodiazepine benzodiazepine-receptor agonists.
European journal of pharmacology 2007;564(1-3):88-93.
2007: S Xie; M A Furjanic; J J Ferrara; N R McAndrew; E L Ardino; A Ngondara; Y Bernstein; K J Thomas; E Kim; J M Walker; Swati Nagar; S J Ward; Robert Raffa
The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use.
Journal of clinical pharmacy and therapeutics 2007;32(3):209-31.
2007: Scott M Rawls; Teresa Gomez; Robert Raffa
An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 55212-2).
Pharmacology, biochemistry, and behavior 2007;86(3):499-504.
2007: Robert Raffa; Gregory W Stagliano; Ronald J Tallarida
Nonlinear isobologram and superadditive withdrawal from cocaine: cannabinoid combinations in planarians.
European journal of pharmacology 2007;556(1-3):89-90.
2006: Robert Raffa; Henry I Jacoby
Endothelin antagonists in CION injury model.
Pain 2006;126(1-3):322; author reply 322-3.
2006: Robert Raffa; Ronald J Tallarida
Modified 'Joyce model' of opioid dependence/withdrawal.
European journal of pharmacology 2006;551(1-3):54-7.
2006: Robert Raffa; Gregory W Stagliano; Ronald J Tallarida
Subadditive withdrawal from cocaine/kappa-opioid agonist combinations in Planaria.
Brain research 2006;1114(1):31-5.
2006: Scott M Rawls; Tonatiu Rodriguez; David A Baron; Robert Raffa
A nitric oxide synthase inhibitor (L-NAME) attenuates abstinence-induced withdrawal from both cocaine and a cannabinoid agonist (WIN 55212-2) in Planaria.
Brain research 2006;1099(1):82-7.
2006: Robert Raffa; David A Baron; Ronald J Tallarida
Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria.
European journal of pharmacology 2006;540(1-3):200-1.
2006: Wu-Nan Wu; Linda A McKown; Ellen E Codd; Robert Raffa
Metabolism of two analgesic agents, tramadol-n-oxide and tramadol, in specific pathogen-free and axenic mice.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(6):551-65.
2006: Scott M Rawls; Teresa Gomez; Gregory W Stagliano; Robert Raffa
Measurement of glutamate and aspartate in Planaria.
Journal of pharmacological and toxicological methods 2006;53(3):291-5.
2006: Robert Raffa; P V Duong; J Finney; D A Garber; L M Lam; S S Mathew; N N Patel; K C Plaskett; M Shah; H-F Jen Weng
Is 'chemo-fog'/'chemo-brain' caused by cancer chemotherapy?
Journal of clinical pharmacy and therapeutics 2006;31(2):129-38.
2006: I R Bruns; S Chhum; A T Dinh; H Doerr; N R Dunn; Y T Ly; C L Mitman; H D Rickards; C Sol; E W Wan; Robert Raffa
A potential novel strategy to separate therapeutic- and side-effects that are mediated via the same receptor: beta-arrestin2/G-protein coupling antagonists.
Journal of clinical pharmacy and therapeutics 2006;31(2):119-28.
2006: Robert Raffa
Pharmacological aspects of successful long-term analgesia.
Clinical rheumatology 2006;25 Suppl 1():S9-15.
2005: Hongfei Yue; Michael R Borenstein; Susan A Jansen; Robert Raffa
Liquid chromatography-mass spectrometric analysis of buprenorphine and its N-dealkylated metabolite norbuprenorphine in rat brain tissue and plasma.
Journal of pharmacological and toxicological methods 2005;52(3):314-22.
2005: M A Craig; G A Beppler; C Santos; Robert Raffa
A second (non-genomic) steroid mechanism of action: possible opportunity for novel pharmacotherapy?
Journal of clinical pharmacy and therapeutics 2005;30(4):305-12.
2005: Robert J Schulingkamp; Vincent Aloyo; Ronald J Tallarida; Robert Raffa
Changes in aorta alpha1-adrenoceptor number and affinity during one year of streptozotocin-induced diabetes in rats.
Pharmacology 2005;74(1):23-30.
2005: Robert Raffa; Joseph R Iannuzzo; Diana R Levine; Kamal K Saeid; Rachel C Schwartz; Nicholas T Sucic; Oksana D Terleckyj; Jeffrey M Young
Bacterial communication ("quorum sensing") via ligands and receptors: a novel pharmacologic target for the design of antibiotic drugs.
The Journal of pharmacology and experimental therapeutics 2005;312(2):417-23.
2005: Robert Raffa; Prarthna Desai
Description and quantification of cocaine withdrawal signs in Planaria.
Brain research 2005;1032(1-2):200-2.
2005: Robert Raffa; Andrea F Martley
Amphetamine-induced increase in planarian locomotor activity and block by UV light.
Brain research 2005;1031(1):138-40.
2005: Sumiyo Umeda; Gregory W Stagliano; Michael R Borenstein; Robert Raffa
A reverse-phase HPLC and fluorescence detection method for measurement of 5-hydroxytryptamine (serotonin) in Planaria.
Journal of pharmacological and toxicological methods 2005;51(1):73-6.
2004: Robert Raffa; Ellen A Walker; Steven N Sterious
Opioid receptors and acetaminophen (paracetamol).
European journal of pharmacology 2004;503(1-3):209-10.
2004: Shawn D Spencer; Robert Raffa
Isothermal titration calorimetric study of RNase-A kinetics (cCMP --> 3'-CMP) involving end-product inhibition.
Pharmaceutical research 2004;21(9):1642-7.
2004: Sumiyo Umeda; Gregory W Stagliano; Robert Raffa
Cocaine and kappa-opioid withdrawal in Planaria blocked by D-, but not L-, glucose.
Brain research 2004;1018(2):181-5.
2004: Robert Raffa; Gregory W Stagliano; Shawn D Spencer
Protonation effect on drug affinity.
European journal of pharmacology 2004;483(2-3):323-4.
2003: Robert Raffa
Mechanism of action of analgesics used to treat osteoarthritis pain.
Rheumatic diseases clinics of North America 2003;29(4):733-45.
2003: Robert Raffa; C S Dasrath; D R Brown
Disruption of a drug-induced choice behavior by UV light.
Behavioural pharmacology 2003;14(7):569-71.
2003: Ronald J Tallarida; Alan Cowan; Robert Raffa
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
The Journal of pharmacology and experimental therapeutics 2003;307(2):699-704.
2003: Robert Raffa; Gregory W Stagliano; Sumiyo Umeda
kappa-Opioid withdrawal in Planaria.
Neuroscience letters 2003;349(3):139-42.
2003: Robert Raffa; Rachel Clark-Vetri; Ronald J Tallarida; Albert I Wertheimer
Combination strategies for pain management.
Expert opinion on pharmacotherapy 2003;4(10):1697-708.
2002: Robert Raffa
Harmonic mean relationship between affinity for wild-type receptors and alanine-scan mutants.
Journal of theoretical biology 2002;218(2):207-14.
2002: Rebecca P Martinez; Robert Raffa
LiCl attenuates M(1)AChR-mediated intrathecal pilocarpine-induced reciprocal hindlimb scratching in mice.
Pharmacology 2002;65(4):210-4.
2002: Wu-Nan Wu; Linda A McKown; Ellen E Codd; Robert Raffa
In vitro metabolism of the analgesic agent, tramadol-N-oxide, in mouse, rat, and human.
European journal of drug metabolism and pharmacokinetics 2002;27(3):193-7.
2002: Robert Raffa; Shawn D Spencer; Robert J Schulingkamp
Toward RNase inhibitors: thermodynamics of 2'-CMP/RNase-A binding in multi-ion buffer.
Biochemical pharmacology 2002;63(11):1937-9.
2002: A F Maiorini; M J Gaunt; T M Jacobsen; A E McKay; L D Waldman; Robert Raffa
Potential novel targets for Alzheimer pharmacotherapy: I. Secretases.
Journal of clinical pharmacy and therapeutics 2002;27(3):169-83.
2002: Anne Schock Citver; Anastasia M Shields; Lisa M Ciaccia; Robert J Schulingkamp; Robert Raffa
Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: III. Retinoids.
Journal of clinical pharmacy and therapeutics 2002;27(3):161-8.
2002: Shawn D Spencer; Oluseyi Abdul; Robert J Schulingkamp; Robert Raffa
Toward the design of ribonuclease (RNase) inhibitors: ion effects on the thermodynamics of binding of 2'-CMP to RNase A.
The Journal of pharmacology and experimental therapeutics 2002;301(3):925-9.
2002: Q Tao; Dennis J Stone; Michael R Borenstein; Ellen E Codd; TP Coogan; Daksha Desai-Krieger; S Liao; Robert Raffa
Differential tramadol and O-desmethyl metabolite levels in brain vs. plasma of mice and rats administered tramadol hydrochloride orally.
Journal of clinical pharmacy and therapeutics 2002;27(2):99-106.
2002: Robert Raffa
Acetaminophen and metabolite: lack of effect on nitric oxide synthase (constitutive or inducible).
Headache 2002;42(3):237-8.
2001: Q Tao; Dennis J Stone; Michael R Borenstein; V Jean-Bart; Ellen E Codd; TP Coogan; Daksha Desai-Krieger; S Liao; Robert Raffa
Gas chromatographic method using nitrogen-phosphorus detection for the measurement of tramadol and its O-desmethyl metabolite in plasma and brain tissue of mice and rats.
Journal of chromatography. B, Biomedical sciences and applications 2001;763(1-2):165-71.
2001: Robert Raffa; J M Valdez
Cocaine withdrawal in Planaria.
European journal of pharmacology 2001;430(1):143-5.
2001: Robert Raffa
Pharmacology of oral combination analgesics: rational therapy for pain.
Journal of clinical pharmacy and therapeutics 2001;26(4):257-64.
2001: Wu-Nan Wu; Linda A McKown; A D Gauthier; William J Jones; Robert Raffa
Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(7):423-41.
2001: Robert Raffa; L J Holland; Robert J Schulingkamp
Quantitative assessment of dopamine D2 antagonist activity using invertebrate (Planaria) locomotion as a functional endpoint.
Journal of pharmacological and toxicological methods 2001;45(3):223-6.
2001: Robert Raffa
Antihistamines as analgesics.
Journal of clinical pharmacy and therapeutics 2001;26(2):81-5.
2001: Robert E Boyd; J B Press; C R Rasmussen; Robert Raffa; Ellen E Codd; CD Connelly; Q S Li; Rebecca P Martinez; MA Lewis; H R Almond; Allen B Reitz
Alpha(2) adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes.
Journal of medicinal chemistry 2001;44(6):863-72.
2001: Robert Raffa; Dennis J Stone; Ronald J Tallarida
Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine.
European journal of pharmacology 2001;412(2):R1-2.
2000: Robert J Schulingkamp; T C Pagano; D Hung; Robert Raffa
Insulin receptors and insulin action in the brain: review and clinical implications.
Neuroscience and biobehavioral reviews 2000;24(8):855-72.
2000: Robert Raffa; J M Valdez; L J Holland; Robert J Schulingkamp
Energy-dependent UV light-induced disruption of (-)sulpiride antagonism of dopamine.
European journal of pharmacology 2000;406(3):R11-2.
2000: Robert Raffa; Dennis J Stone; Ronald J Tallarida
Discovery of "self-synergistic" spinal/supraspinal antinociception produced by acetaminophen (paracetamol).
The Journal of pharmacology and experimental therapeutics 2000;295(1):291-4.
2000: D M Hunsinger; T Nguyen; S E Zebraski; Robert Raffa
Is there a basis for novel pharmacotherapy of autism?
Life sciences 2000;67(14):1667-82.
2000: S Logani; M C Chen; T Tran; T Le; Robert Raffa
Actions of Ginkgo Biloba related to potential utility for the treatment of conditions involving cerebral hypoxia.
Life sciences 2000;67(12):1389-96.
2000: M L Carfagno; L A Hoskins; M E Pinto; J C Yeh; Robert Raffa
Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: II. Glutamate (Ant)agonists.
The Annals of pharmacotherapy 2000;34(6):788-97.
2000: Robert Raffa; C Wu; Dennis J Stone; Michael R Borenstein; Ellen E Codd; TP Coogan
Determination of the adsorption of tramadol hydrochloride by activated charcoal in vitro and in vivo.
Journal of pharmacological and toxicological methods 2000;43(3):205-10.
2000: Tina M Ross; Michele C Jetter; Mark E McDonnell; Robert E Boyd; CD Connelly; Rebecca P Martinez; MA Lewis; Ellen E Codd; Robert Raffa; Allen B Reitz
Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor.
Journal of medicinal chemistry 2000;43(7):1423-6.
2000: Tina M Ross; Michele C Jetter; Mark E McDonnell; Robert E Boyd; CD Connelly; Rebecca P Martinez; MA Lewis; Ellen E Codd; Robert Raffa; Allen B Reitz
alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor.
Journal of medicinal chemistry 2000;43(5):765-8.
2000: C Betz; D Mihalic; M E Pinto; Robert Raffa
Could a common biochemical mechanism underlie addictions?
Journal of clinical pharmacy and therapeutics 2000;25(1):11-20.
2000: S E Zebraski; S M Kochenash; Robert Raffa
Lung opioid receptors: pharmacology and possible target for nebulized morphine in dyspnea.
Life sciences 2000;66(23):2221-31.
1999: Robert E Boyd; J B Press; C R Rasmussen; Robert Raffa; Ellen E Codd; CD Connelly; D J Bennett; A L Kirifides; J F Gardocki; B Reynolds; J T Hortenstein; Allen B Reitz
Alpha(2) adrenoceptor agonists as potential analgesic agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles.
Journal of medicinal chemistry 1999;42(25):5064-71.
1999: S Baby; M Nguyen; D Tran; Robert Raffa
Substance P antagonists: the next breakthrough in treating depression?
Journal of clinical pharmacy and therapeutics 1999;24(6):461-9.
1999: Q S Li; CD Connelly; Ellen E Codd; Robert Raffa
Method for comparison of the hemodynamic effects of equi-antinociceptive oral doses of drugs in anesthetized rats.
Journal of pharmacological and toxicological methods 1999;42(3):127-33.
1999: JM Lashbrook; Michael H Ossipov; John C Hunter; Robert Raffa; Ronald J Tallarida; Frank Porreca
Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats.
Pain 1999;82(1):65-72.
1999: Di Bian; Michael H Ossipov; mukwaya Ibrahim; Robert Raffa; Ronald J Tallarida; T Philip Malan; Josephine Lai; Frank Porreca
Loss of antiallodynic and antinociceptive spinal/supraspinal morphine synergy in nerve-injured rats: restoration by MK-801 or dynorphin antiserum.
Brain research 1999;831(1-2):55-63.
1999: D A Dixon; L A Fenix; D M Kim; Robert Raffa
Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: I. Adenosine agonists.
The Annals of pharmacotherapy 1999;33(4):480-8.
1999: Ronald J Tallarida; Dennis J Stone; J D McCary; Robert Raffa
Response surface analysis of synergism between morphine and clonidine.
The Journal of pharmacology and experimental therapeutics 1999;289(1):8-13.
1999: Robert Raffa; Dennis J Stone; S J Hipp
Differential cholera-toxin sensitivity of supraspinal antinociception induced by the cannabinoid agonists delta9-THC, WIN 55,212-2 and anandamide in mice.
Neuroscience letters 1999;263(1):29-32.
1999: Robert Raffa
(Extra)thermodynamics of the drug-receptor interaction.
Life sciences 1999;65(10):967-80.
1998: D A Bennett; L Phun; J F Polk; S A Voglino; V Zlotnik; Robert Raffa
Neuropharmacology of St. John's Wort (Hypericum).
The Annals of pharmacotherapy 1998;32(11):1201-8.
1998: Robert Raffa
Possible role(s) of neurokinins in CNS development and neurodegenerative or other disorders.
Neuroscience and biobehavioral reviews 1998;22(6):789-813.
1998: Jian-Guo Li; Robert Raffa; P Cheung; Tsang-Bin Tzeng; Lee-Yuan Liu-Chen
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
European journal of pharmacology 1998;354(2-3):227-37.
1998: Todd W Vanderah; Robert Raffa; JM Lashbrook; A Burritt; Victor J Hruby; Frank Porreca
Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats.
European journal of pain (London, England) 1998;2(3):267-78.
1998: CJ Kovelowski; Robert Raffa; Frank Porreca
Tramadol and its enantiomers differentially suppress c-fos-like immunoreactivity in rat brain and spinal cord following acute noxious stimulus.
European journal of pain (London, England) 1998;2(3):211-9.
1998: Robert Raffa; Dennis J Stone
Mu receptor and Gi2alpha antisense attenuate [D-Met2]-FMRFamide antinociception in mice.
Peptides 1998;19(7):1171-5.
1998: Robert Raffa
Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding.
Life sciences 1998;62(16):PL265-70.
1997: Ronald J Tallarida; Dennis J Stone; Robert Raffa
Efficient designs for studying synergistic drug combinations.
Life sciences 1997;61(26):PL 417-25.
1997: T L Goode; Robert Raffa
An examination of the relationship between mu-opioid antinociceptive efficacy and G-protein coupling using pertussis and cholera toxins.
Life sciences 1997;60(7):PL107-13.
1996: Josephine Lai; S W Ma; F Porreca; Robert Raffa
Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells.
European journal of pharmacology 1996;316(2-3):369-72.
1996: Robert Raffa
Comments on Carmody, Pain, 63 (1995) 136.
Pain 1996;67(1):215-8.
1996: Robert Raffa; M L Haslego; C A Maryanoff; F J Villani; Ellen E Codd; CD Connelly; R P Martinez; J J Schupsky; J A Buben; Wu-Nan Wu; A N Takacs; Linda A McKown
Unexpected antinociceptive effect of the N-oxide (RWJ 38705) of tramadol hydrochloride.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1098-104.
1996: Robert Raffa
A novel approach to the pharmacology of analgesics.
The American journal of medicine 1996;101(1A):40S-46S.
1996: Robert Raffa; J J Schupsky; D K Lee; H I Jacoby
Characterization of endothelin-induced nociception in mice: evidence for a mechanistically distinct analgesic model.
The Journal of pharmacology and experimental therapeutics 1996;278(1):1-7.
1996: Robert Raffa; J J Schupsky; H I Jacoby
Endothelin-induced nociception in mice: mediation by ETA and ETB receptors.
The Journal of pharmacology and experimental therapeutics 1996;276(2):647-51.
1996: Robert Raffa; D J Stone
Could dual G-protein coupling explain [D-Met2]FMRFamide's mixed action in vivo?
Peptides 1996;17(8):1261-5.
1996: Robert Raffa; Ellen E Codd
Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays).
Life sciences 1996;59(2):PL37-40.
1996: Ronald J Tallarida; Robert Raffa
Testing for synergism over a range of fixed ratio drug combinations: replacing the isobologram.
Life sciences 1996;58(2):PL 23-8.
1996: Robert Raffa; C D Connelly; J R Chambers; D J Stone
Alpha-subunit G-protein antisense oligodeoxynucleotide effects on supraspinal (i.c.v.) alpha2-adrenoceptor antinociception in mice.
Life sciences 1996;58(5):PL 77-80.
1996: Robert Raffa; T L Goode; R P Martinez; H I Jacoby
A Gi2alpha antisense oligonucleotide differentiates morphine antinociception, constipation and acute dependence in mice.
Life sciences 1996;58(5):PL 73-6.
1995: Ellen E Codd; Richard P Shank; J J Schupsky; Robert Raffa
Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1263-70.
1995: Robert Raffa; R P Martinez
Antinociceptive defect of beige-J mice reversed by i.c.v. IP3 or myo-inositol.
Neuroreport 1995;6(10):1434-6.
1995: Robert Raffa; R P Martinez
The 'glibenclamide-shift' of centrally-acting antinociceptive agents in mice.
Brain research 1995;677(2):277-82.
1995: Robert Raffa; R P Martinez; M J Renzi; Ellen E Codd
LiCl uncouples signal transduction in morphine-induced supraspinal antinociception in mice.
General pharmacology 1995;26(2):317-20.
1995: Ellen E Codd; J B Press; Robert Raffa
Alpha 2-adrenoceptors vs. imidazoline receptors: implications for alpha 2-mediated analgesia and other non-cardiovascular therapeutic uses.
Life sciences 1995;56(2):63-74.
1994: K D Wild; F Porreca; Henry I Yamamura; Robert Raffa
Differentiation of receptor subtypes by thermodynamic analysis: application to opioid delta receptors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12018-21.
1994: Robert Raffa; Ellen E Codd
Lack of glibenclamide or TEA affinity for opioid receptors: further evidence for in vivo modulation of antinociception at K+ channels.
Brain research 1994;650(1):146-8.
1994: Robert Raffa; R P Martinez; CD Connelly
G-protein antisense oligodeoxyribonucleotides and mu-opioid supraspinal antinociception.
European journal of pharmacology 1994;258(1-2):R5-7.
1994: Richard P Shank; J F Gardocki; J L Vaught; C B Davis; J J Schupsky; Robert Raffa; S J Dodgson; Samuel O Nortey; Bruce E Maryanoff
Topiramate: preclinical evaluation of structurally novel anticonvulsant.
Epilepsia 1994;35(2):450-60.
1994: Robert Raffa; J J Schupsky
Opioid mu receptor subtypes (possibly mu 1 and mu 2) revealed by morphine-induced antinociception vs endothelin-1 in recombinant inbred CXBK mice.
Life sciences 1994;54(4):PL57-62.
1994: Robert Raffa; A Kim; K C Rice; B R de Costa; Ellen E Codd; R B Rothman
Low affinity of FMRFamide and four FaRPs (FMRFamide-related peptides), including the mammalian-derived FaRPs F-8-Famide (NPFF) and A-18-Famide, for opioid mu, delta, kappa 1, kappa 2a, or kappa 2b receptors.
Peptides 1994;15(3):401-4.
1994: CD Connelly; R P Martinez; J J Schupsky; F Porreca; Robert Raffa
Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception.
Life sciences 1994;54(21):PL369-74.
1993: Robert Raffa; E Friderichs; W Reimann; Richard P Shank; Ellen E Codd; J L Vaught; H I Jacoby; N Selve
Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.
The Journal of pharmacology and experimental therapeutics 1993;267(1):331-40.
1993: Robert Raffa; R P Martinez; CD Connelly
Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo.
Neuroscience letters 1993;158(1):87-91.
1993: Robert Raffa; K D Wild; H I Mosberg; F Porreca
Thermodynamic parameters for [D-Pen2,5]enkephalin at delta-opioid receptors in the mouse isolated vas deferens.
European journal of pharmacology 1993;244(3):231-8.
1993: Robert Raffa; J R Mathiasen; E S Kimball; J L Vaught
The combined immunological and antinociceptive defects of beige-J mice: the possible existence of a 'mu-repressin'.
Life sciences 1993;52(1):1-8.
1993: L O Nordberg; Robert Raffa; Ronald J Tallarida
Determination of the drug-receptor dissociation constant of endothelin-1 using photorelaxation of rabbit isolated thoracic aorta.
Life sciences 1993;53(3):PL33-8.
1992: Robert Raffa; K D Wild; H I Mosberg; F Porreca
Thermodynamic analysis of the temperature dependence of the dissociation constant of naloxone at opioid delta receptors in the mouse isolated vas deferens.
The Journal of pharmacology and experimental therapeutics 1992;263(3):1030-5.
1992: J R Carson; R J Carmosin; J L Vaught; J F Gardocki; Michael J Costanzo; Robert Raffa; H R Almond
2-Substituted 1-azabicycloalkanes, a new class of non-opiate antinociceptive agents.
Journal of medicinal chemistry 1992;35(15):2855-63.
1992: Robert Raffa; CD Connelly; R P Martinez
Opioid efficacy is linked to the LiCl-sensitive, inositol-1,4,5-trisphosphate-restorable pathway.
European journal of pharmacology 1992;217(2-3):221-3.
1992: Robert Raffa; C D Connelly
Supraspinal antinociception produced by [D-Met2]-FMRFamide in mice.
Neuropeptides 1992;22(3):195-203.
1992: Robert Raffa; R P Martinez; F Porreca
Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the mu-opioid receptor deficient CXBK mouse.
European journal of pharmacology 1992;216(3):453-6.
1992: Robert Raffa; R P Martinez
Morphine antinociception is mediated through a LiCl-sensitive, IP3-restorable pathway.
European journal of pharmacology 1992;215(2-3):357-8.
1992: Robert Raffa; M F Addo; A Gill
Supraspinal administration of [D-Met2]FMRFamide produces a naloxone-sensitive increase in heart rate in unrestrained spontaneously hypertensive rats.
Neuropeptides 1992;21(4):201-5.
1992: Ronald J Tallarida; Robert Raffa
Receptor regulation, competitive antagonism and pA2.
Life sciences 1992;51(7):PL61-5.
1992: Robert Raffa; J F Aceto; J E Goldschmidt; Ronald J Tallarida
The effect of lowered extracellular Na+ concentration on ultraviolet light-induced relaxation of vasoconstricted rabbit isolated thoracic aorta.
Life sciences 1992;51(25):PL249-54.
1992: Robert Raffa; Richard P Shank; J L Vaught
Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity.
Psychopharmacology 1992;108(3):320-6.
1992: Robert Raffa; E Friderichs; W Reimann; Richard P Shank; Ellen E Codd; J L Vaught
Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.
The Journal of pharmacology and experimental therapeutics 1992;260(1):275-85.
1991: Robert Raffa; N Orr; CD Connelly; R M Hollingworth
XAMI and DCDM, agonists at cAMP-associated octopamine receptors in cockroach nerve cord, produce centrally mediated antinociception in mice.
Brain research 1991;559(2):211-9.
1991: H I Jacoby; A C Bonfilio; Robert Raffa
Central and peripheral administration of serotonin produces opposite effects on mouse colonic propulsive motility.
Neuroscience letters 1991;122(1):122-6.
1991: J L Vaught; Robert Raffa
Centrally-mediated antinociceptive action of RWJ-22757 (formerly McN-5195): involvement of spinal descending inhibitory pathways (an hypothesis).
Life sciences 1991;48(23):2233-41.
1991: Robert Raffa; J J Schupsky; R P Martinez; H I Jacoby
Endothelin-1-induced nociception.
Life sciences 1991;49(11):PL61-5.
1991: Robert Raffa; H I Jacoby
Endothelin-1, -2 and -3 directly and big-endothelin-1 indirectly elicit an abdominal constriction response in mice.
Life sciences 1991;48(17):PL85-90.
1990: Robert Raffa; J L Vaught; P E Setler
The novel anticonvulsant loreclezole (R 72063) does not produce diazepam-like anterograde amnesia in a passive avoidance test in rats.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(5):613-5.
1990: J L Vaught; J R Carson; R J Carmosin; P S Blum; F J Persico; W E Hageman; Richard P Shank; Robert Raffa
Antinociceptive action of McN-5195 in rodents: a structurally novel (indolizine) analgesic with a nonopioid mechanism of action.
The Journal of pharmacology and experimental therapeutics 1990;255(1):1-10.
1990: Robert Raffa; H I Jacoby
Effect of Phe-D-Met-Arg-Phe-NH2 and other Phe-Met-Arg-Phe-NH2-related peptides on mouse colonic propulsive motility: a structure-activity relationship study.
The Journal of pharmacology and experimental therapeutics 1990;254(3):809-14.
1990: Robert Raffa; C D Connelly
[D-Met2]-FMRFamide (DMFa): production of naloxone-sensitive antinociception in mouse tail-flick test.
NIDA research monograph 1990;105():391-2.
1990: Robert Raffa
The actions of FMRF-NH2 and FMRF-NH2 related peptides on mammals.
NIDA research monograph 1990;105():243-9.
1989: Robert Raffa; J R Mathiasen; T L Goode
Central administration of p-octopamine to mice: assessment of antinociception.
European journal of pharmacology 1989;169(2-3):317-20.
1989: Robert Raffa; H I Jacoby
A-18-famide and F-8-famide, endogenous mammalian equivalents of the molluscan neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2), inhibit colonic bead expulsion time in mice.
Peptides 1989;10(4):873-5.
1989: E S Kimball; Robert Raffa
Obligatory role of B cells and adherent accessory cells in the transfer of a defect in morphine-mediated antinociception in C57BL/6J-bg/bg (beige-J) mice.
Journal of neuroimmunology 1989;22(3):185-92.
1989: Robert Raffa; H I Jacoby
FMRFamide enhances acetylcholine-induced contractions of guinea pig ileum.
Peptides 1989;10(3):693-5.
1989: Robert Raffa; J L Vaught; F Porreca
Can equal pA2 values be compatible with receptor differences?
Trends in pharmacological sciences 1989;10(5):183-5.
1989: Robert Raffa
Supraspinal FMRFamide antagonizes morphine-induced horizontal, but not vertical, locomotor activity.
Peptides 1989;10(2):403-6.
1989: Robert Raffa; M E Ortegón; D M Robisch; G E Martin
In vivo demonstration of the enhancement of MK-801 by L-glutamate.
Life sciences 1989;44(21):1593-9.
1989: Robert Raffa; F Porreca
Thermodynamic analysis of the drug-receptor interaction.
Life sciences 1989;44(4):245-58.
1988: Robert Raffa; M E Ortegón; M Watson
Reciprocal hindlimb scratching and putative subtype-selective muscarinic agents.
European journal of pharmacology 1988;158(3):289-92.
1988: Robert Raffa
The action of FMRFamide (Phe-Met-Arg-Phe-NH2) and related peptides on mammals.
Peptides 1988;9(4):915-22.
1988: Robert Raffa; J R Mathiasen; D Q Brown
Mu-, but not delta-, opioid receptor-mediated antinociception in mice is attenuated by gamma-irradiation.
Brain research 1988;447(2):393-7.
1988: Robert Raffa; W J Baldy; Richard P Shank; J R Mathiasen; J L Vaught
[3H][D-Ala2,NMePhe4,Gly-ol5]-enkephalin (mu-opioid) binding in beige-J mice.
Peptides 1988;9(3):637-42.
1988: J S Heyman; J L Vaught; Robert Raffa; F Porreca
Can supraspinal delta-opioid receptors mediate antinociception?
Trends in pharmacological sciences 1988;9(4):134-8.
1988: J L Vaught; J R Mathiasen; Robert Raffa
Examination of the involvement of supraspinal and spinal mu and delta opioid receptors in analgesia using the mu receptor deficient CXBK mouse.
The Journal of pharmacology and experimental therapeutics 1988;245(1):13-6.
1988: Robert Raffa; E S Kimball; J R Mathiasen
The analgesic defect of C57BL/6J-bgJ/bgJ (beige-J: Chediak-Higashi syndrome) mice transmitted by adoptive transfer of spleen cells to normal littermates.
Life sciences 1988;42(12):1231-6.
1987: M B Jacoby; H I Jacoby; J R Mathiasen; Robert Raffa
The effect of Phe-Met-Arg-Phe-NH2 (FMRFamide) on morphine-induced inhibition of colonic propulsive motility in mice.
Neuroscience letters 1987;83(1-2):128-32.
1987: Robert Raffa; J R Mathiasen; H I Jacoby
Colonic bead expulsion time in normal and mu-opioid receptor deficient (CXBK) mice following central (ICV) administration of mu- and delta-opioid agonists.
Life sciences 1987;41(19):2229-34.
1987: Robert Raffa; J R Mathiasen; T L Goode; J L Vaught
Evidence that reciprocal hindlimb scratching elicited in mice by intrathecal administration of muscarinic agonists is mediated through M1 type receptors.
Life sciences 1987;41(15):1831-6.
1987: Robert Raffa; C P Bianchi; S R Narayan
Reversible inhibition of acetylcholine contracture of molluscan smooth muscle by heavy metals: correlation to Ca++ and metal content.
The Journal of pharmacology and experimental therapeutics 1987;243(1):200-4.
1987: Robert Raffa; J R Mathiasen; J L Vaught
Restoration of analgesic response of C57BL/6J-bgJ (beige-J) mice to morphine by carbachol.
European journal of pharmacology 1987;141(3):507-10.
1987: J R Mathiasen; Robert Raffa; J L Vaught
C57BL/6J-bgJ (beige) mice: differential sensitivity in the tail flick test to centrally administered mu- and delta-opioid receptor agonists.
Life sciences 1987;40(20):1989-94.
1987: R W Scott; T L Goode; Robert Raffa
Pilocarpine-induced reciprocal hindlimb scratching in mice.
Pharmacology, biochemistry, and behavior 1987;26(2):327-31.
1986: X Z Zhu; Robert Raffa
Low affinity inhibition of opioid receptor binding by FMRFamide.
Neuropeptides 1986;8(1):55-61.
1986: Robert Raffa; F Porreca
Evidence for a role of conditioning in the development of tolerance to morphine-induced inhibition of gastrointestinal transit in rats.
Neuroscience letters 1986;67(3):229-32.
1986: Robert Raffa; J Heyman; F Porreca
Intrathecal FMRFamide (Phe-Met-Arg-Phe-NH2) induces excessive grooming behavior in mice.
Neuroscience letters 1986;65(1):94-8.
1986: Robert Raffa; C P Bianchi
Antagonism of receptor-activated biological effects mediated by second messenger pathways.
Life sciences 1986;38(3):251-7.
1985: Robert Raffa; J F Aceto; Ronald J Tallarida
Measurement of thermodynamic parameters for norepinephrine contraction of isolated rabbit thoracic aorta.
The Journal of pharmacology and experimental therapeutics 1985;235(3):596-600.
1985: J F Aceto; J Kitzen; Robert Raffa; R J Tallarida
Altered vascular responsiveness to norepinephrine following withdrawal of verapamil in rabbits.
Journal of cardiovascular pharmacology 1985;7(5):1011-2.
1985: Robert Raffa; R J Tallarida
The concept of a changing receptor concentration: implications for the theory of drug action.
Journal of theoretical biology 1985;115(4):625-32.
1983: F Porreca; A Cowan; Robert Raffa; R J Tallarida
Ketazocines and morphine: effects on gastrointestinal transit after central and peripheral administration.
Life sciences 1983;32(15):1785-90.
1982: Robert Raffa; F Porreca; A Cowan; R J Tallarida
Extraction and measurement of morphine: correlation of brain level and s.c. dose in drug-naive and morphine-tolerant rats.
Life sciences 1982;31(20-21):2299-302.
1982: F Porreca; A Cowan; Robert Raffa; R J Tallarida
Estimation in vivo of the receptor constants of morphine in naive and morphine-tolerant rats.
Life sciences 1982;31(20-21):2355-8.
1982: F Porreca; Robert Raffa; A Cowan; R J Tallarida
A comparison of the receptor constants of morphine and ethylketocyclazocine for analgesia and inhibition of gastrointestinal transit in the rat.
Life sciences 1982;31(18):1955-61.
1982: F Porreca; A Cowan; Robert Raffa; R J Tallarida
Tolerance and cross-tolerance studies with morphine and ethylketocyclazocine.
The Journal of pharmacy and pharmacology 1982;34(10):666-7.
1982: F Porreca; A Cowan; Robert Raffa; R J Tallarida
On the criteria for classifying opiate agonists in rats.
The Journal of pharmacy and pharmacology 1982;34(8):525-6.
1982: Robert Raffa; J J O'Neill; R J Tallarida
Rapid extraction and measurement of morphine and opiate antagonists from rat brain using high-performance liquid chromatography and electrochemical detection.
Journal of chromatography 1982;238(2):515-9.
1982: Robert Raffa; F Porreca; A Cowan; R J Tallarida
Morphine-receptor dissociation constant and the stimulus-effect relation for inhibition of gastrointestinal transit in the rat.
European journal of pharmacology 1982;79(1-2):11-6.
1981: Robert Raffa; R J Tallarida
The effect of preload on the dissociation constant of phentolamine in isolated rabbit thoracic aorta.
Archives internationales de pharmacodynamie et de thérapie 1981;251(1):126-35.
1979: Robert Raffa; R J Tallarida; A Gero
Determination of the stimulus-response relation for three alpha-adrenergic agonists on rabbit aorta.
Archives internationales de pharmacodynamie et de thérapie 1979;241(2):197-207.