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Sarah George

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Jason L Johnson; Amrita Dwivedi; Sarah George; Michelle Somerville; Andrew C Newby
Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice.
Jason L Johnson; Laurent Devel; Bertrand Czarny; Sarah George; Christopher L Jackson; Vassilis Rogakos; Fabrice Beau; Athanasios Yiotakis; Andrew C Newby; Vincent Dive
A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice.
Aikaterini Tsaousi; Helen Williams; Cressida A Lyon; Victoria Taylor; Amanda Swain; Jason L Johnson; Sarah George
Wnt4/β-catenin signaling induces VSMC proliferation and is associated with intimal thickening.

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All Publications

2011: Jason L Johnson; Amrita Dwivedi; Sarah George; Michelle Somerville; Andrew C Newby
Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(9):e35-44.
2011: Jason L Johnson; Laurent Devel; Bertrand Czarny; Sarah George; Christopher L Jackson; Vassilis Rogakos; Fabrice Beau; Athanasios Yiotakis; Andrew C Newby; Vincent Dive
A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(3):528-35.
2011: Aikaterini Tsaousi; Helen Williams; Cressida A Lyon; Victoria Taylor; Amanda Swain; Jason L Johnson; Sarah George
Wnt4/β-catenin signaling induces VSMC proliferation and is associated with intimal thickening.
Circulation research 2011;108(4):427-36.
2010: Cressida A Lyon; Evgenia Koutsouki; Concepcion M Aguilera; Orest W Blaschuk; Sarah George
Inhibition of N-cadherin retards smooth muscle cell migration and intimal thickening via induction of apoptosis.
Journal of vascular surgery 2010;52(5):1301-9.
2010: Helen Williams; Jason L Johnson; Christopher L Jackson; Stephen J White; Sarah George
MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis.
Cardiovascular research 2010;87(1):137-46.
2010: Sarah George; Jason L Johnson
In situ zymography.
Methods in molecular biology (Clifton, N.J.) 2010;622():271-7.
2009: Andrew C Newby; Sarah George; Yasmin Ismail; Jason L Johnson; Graciela B Sala-Newby; Anita C Thomas
Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes.
Thrombosis and haemostasis 2009;101(6):1006-11.
2009: Cressida A Lyon; Jason L Johnson; Helen Williams; Graciela B Sala-Newby; Sarah George
Soluble N-cadherin overexpression reduces features of atherosclerotic plaque instability.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(2):195-201.
2008: Angelika B Kritz; Jun Yu; Paulette L Wright; Song Wan; Sarah George; Crawford Halliday; Ning Kang; William C Sessa; Andrew H Baker
In vivo modulation of Nogo-B attenuates neointima formation.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(11):1798-804.
2008: Amrita Dwivedi; Graciela B Sala-Newby; Sarah George
Regulation of cell-matrix contacts and beta-catenin signaling in VSMC by integrin-linked kinase: implications for intimal thickening.
Basic research in cardiology 2008;103(3):244-56.
2008: Sarah George
Wnt pathway: a new role in regulation of inflammation.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(3):400-2.
2007: John Paul Kirton; Nicola J Crofts; Sarah George; Keith Brennan; Ann E Canfield
Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease?
Circulation research 2007;101(6):581-9.
2007: Sandra Magnoni; A Baker; S Thomson; G Jordan; Sarah George; Barry W McColl; James McCulloch; Karen Horsburgh
Neuroprotective effect of adenoviral-mediated gene transfer of TIMP-1 and -2 in ischemic brain injury.
Gene therapy 2007;14(7):621-5.
2007: Gavin J Murphy; Thomas W Johnson; Martin H Chamberlain; Syed I A Rizvi; Marcie Wyatt; Sarah George; Gianni Angelini; Karl R Karsch; Martin Oberhoff; Andrew C Newby
Short- and long-term effects of cytochalasin D, paclitaxel and rapamycin on wall thickening in experimental porcine vein grafts.
Cardiovascular research 2007;73(3):607-17.
2006: Helen Quasnichka; Sadie C Slater; Cressida A Beeching; Manfred Boehm; Graciela B Sala-Newby; Sarah George
Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression.
Circulation research 2006;99(12):1329-37.
2006: Sarah George; Cressida A Beeching
Cadherin:catenin complex: a novel regulator of vascular smooth muscle cell behaviour.
Atherosclerosis 2006;188(1):1-11.
2006: Sarah George; Keith M Channon; Andrew H Baker
Gene therapy and coronary artery bypass grafting: current perspectives.
Current opinion in molecular therapeutics 2006;8(4):288-94.
2006: Jason L Johnson; Regina Fritsche-Danielson; Margareta Behrendt; Annika Westin-Eriksson; Håkan Wennbo; Margareta Herslof; Marie Elebring; Sarah George; William L McPheat; Christopher L Jackson
Effect of broad-spectrum matrix metalloproteinase inhibition on atherosclerotic plaque stability.
Cardiovascular research 2006;71(3):586-95.
2006: Jason L Johnson; Andrew H Baker; Kazuhiro Oka; Lawrence Chan; Andrew C Newby; Christopher L Jackson; Sarah George
Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis.
Circulation 2006;113(20):2435-44.
2005: Graciela B Sala-Newby; Sarah George; Mark Bond; Gurtej K Dhoot; Andrew C Newby
Regulation of vascular smooth muscle cell proliferation, migration and death by heparan sulfate 6-O-endosulfatase1.
FEBS letters 2005;579(28):6493-8.
2005: Jason L Johnson; Sarah George; Andrew C Newby; Christopher L Jackson
Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(43):15575-80.
2005: Sarah George; Jason L Johnson; Melanie A Smith; Gianni Angelini; Christopher L Jackson
Transforming growth factor-beta is activated by plasmin and inhibits smooth muscle cell death in human saphenous vein.
Journal of vascular research 2005;42(3):247-54.
2005: Evgenia Koutsouki; Cressida A Beeching; Sadie C Slater; Orest W Blaschuk; Graciela B Sala-Newby; Sarah George
N-cadherin-dependent cell-cell contacts promote human saphenous vein smooth muscle cell survival.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(5):982-8.
2004: Sandra Magnoni; Andrew Baker; Sarah George; W Colin Duncan; Lorraine E Kerr; James McCulloch; Karen Horsburgh
Differential alterations in the expression and activity of matrix metalloproteinases 2 and 9 after transient cerebral ischemia in mice.
Neurobiology of disease 2004;17(2):188-97.
2004: Sadie C Slater; Evgenia Koutsouki; Christopher L Jackson; Raymond C Bush; Gianni Angelini; Andrew C Newby; Sarah George
R-cadherin:beta-catenin complex and its association with vascular smooth muscle cell proliferation.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(7):1204-10.
2004: Risto Ala-Aho; Matti Ahonen; Sarah George; Jari Heikkilä; Reidar Grénman; Markku Kallajoki; Veli-Matti Kähäri
Targeted inhibition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo.
Oncogene 2004;23(30):5111-23.
2004: Song Wan; Sarah George; Stuart A Nicklin; Anthony P C Yim; Andrew H Baker
Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(5):689-98.
2004: Sarah George; Amrita Dwivedi
MMPs, cadherins, and cell proliferation.
Trends in cardiovascular medicine 2004;14(3):100-5.
2003: Kate L Dishart; Laura Denby; Sarah George; Stuart A Nicklin; Satya Yendluri; Melanie J Tuerk; Michael P Kelley; Brian A Donahue; Andrew C Newby; Thomas C Harding; Andrew H Baker
Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy.
Journal of molecular and cellular cardiology 2003;35(7):739-48.
2003: Elizabeth B Uglow; Sadie C Slater; Graciela B Sala-Newby; CONCEPCION AGUILERA; Gianni Angelini; Andrew C Newby; Sarah George
Dismantling of cadherin-mediated cell-cell contacts modulates smooth muscle cell proliferation.
Circulation research 2003;92(12):1314-21.
2003: CONCEPCION AGUILERA; Sarah George; Jason L Johnson; Andrew C Newby
Relationship between type IV collagen degradation, metalloproteinase activity and smooth muscle cell migration and proliferation in cultured human saphenous vein.
Cardiovascular research 2003;58(3):679-88.
2002: Sarah George; Andrew H Baker
Gene transfer to the vasculature: historical perspective and implication for future research objectives.
Molecular biotechnology 2002;22(2):153-64.
2002: Matti Ahonen; Risto Ala-Aho; Andrew H Baker; Sarah George; Reidar Grénman; Ulpu Saarialho-Kere; Veli-Matti Kähäri
Antitumor activity and bystander effect of adenovirally delivered tissue inhibitor of metalloproteinases-3.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):705-15.
2001: Sarah George; Jason L Johnson; M A Smith; Christopher L Jackson
Plasmin-mediated fibroblast growth factor-2 mobilisation supports smooth muscle cell proliferation in human saphenous vein.
Journal of vascular research 2001;38(5):492-501.
2001: Jason Lee Johnson; G J van Eys; Gianni Angelini; Sarah George
Injury induces dedifferentiation of smooth muscle cells and increased matrix-degrading metalloproteinase activity in human saphenous vein.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(7):1146-51.
2001: Sarah George; Gianni Angelini; M C Capogrossi; Andrew H Baker
Wild-type p53 gene transfer inhibits neointima formation in human saphenous vein by modulation of smooth muscle cell migration and induction of apoptosis.
Gene therapy 2001;8(9):668-76.
2001: Sarah George; MOHAMMAD IZZAT; Patricia Gadsdon; Jason Lee Johnson; A P Yim; S Wan; Andrew C Newby; Gianni Angelini; Jamie Y Jeremy
Macro-porosity is necessary for the reduction of neointimal and medial thickening by external stenting of porcine saphenous vein bypass grafts.
Atherosclerosis 2001;155(2):329-36.
2001: C T Lloyd; Sarah George; G D Angelini; A C Newby; Andrew H Baker
A pig model of vein graft disease applications for potential gene therapies.
Methods in molecular medicine 2001;52():233-43.
2001: Sarah George; Andrew H Baker
Gene transfer to the vasculature historical perspective and implications for future research objectives.
Methods in molecular medicine 2001;52():219-31.
2001: Sarah George; Jason Lee Johnson
In situ zymography.
Methods in molecular biology (Clifton, N.J.) 2001;151():411-5.
2000: Sarah George
Therapeutic potential of matrix metalloproteinase inhibitors in atherosclerosis.
Expert opinion on investigational drugs 2000;9(5):993-1007.
2000: Sarah George; Clinton T Lloyd; Gianni Angelini; Andrew C Newby; Andrew H Baker
Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3.
Circulation 2000;101(3):296-304.
1999: AB Zaltsman; Sarah George; Andrew C Newby
Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 from the aortas of cholesterol fed rabbits partially counterbalances increased metalloproteinase activity.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(7):1700-7.
1999: Andrew H Baker; Sarah George; AB Zaltsman; Gillian Murphy; Andrew C Newby
Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3.
British journal of cancer 1999;79(9-10):1347-55.
1999: A Kranzhöfer; Andrew H Baker; Sarah George; Andrew C Newby
Expression of tissue inhibitor of metalloproteinase-1, -2, and -3 during neointima formation in organ cultures of human saphenous vein.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(2):255-65.
1999: Sarah George; Andrew H Baker
Delivery of recombinant adenoviruses to human saphenous vein.
Methods in molecular medicine 1999;30():357-64.
1998: Sarah George; Andrew H Baker; Gianni Angelini; Andrew C Newby
Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins.
Gene therapy 1998;5(11):1552-60.
1998: Jason Lee Johnson; Christopher L Jackson; Gianni Angelini; Sarah George
Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(11):1707-15.
1998: Sarah George
Tissue inhibitors of metalloproteinases and metalloproteinases in atherosclerosis.
Current opinion in lipidology 1998;9(5):413-23.
1998: Sarah George; Jason Lee Johnson; Gianni Angelini; Andrew C Newby; Andrew H Baker
Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein.
Human gene therapy 1998;9(6):867-77.
1998: Andrew H Baker; AB Zaltsman; Sarah George; Andrew C Newby
Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.
The Journal of clinical investigation 1998;101(6):1478-87.
1998: D Mehta; Sarah George; Jamie Y Jeremy; MOHAMMAD IZZAT; Kay M Southgate; A J Bryan; Andrew C Newby; Gianni Angelini
External stenting reduces long-term medial and neointimal thickening and platelet derived growth factor expression in a pig model of arteriovenous bypass grafting.
Nature medicine 1998;4(2):235-9.
1997: Sarah George; Jason Lee Johnson; Gianni Angelini; Jamie Y Jeremy
Short-term exposure to thapsigargin inhibits neointima formation in human saphenous vein.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2500-6.
1997: Andrew H Baker; D Mehta; Sarah George; Gianni Angelini
Prevention of vein graft failure: potential applications for gene therapy.
Cardiovascular research 1997;35(3):442-50.
1997: Sarah George; AB Zaltsman; Andrew C Newby
Surgical preparative injury and neointima formation increase MMP-9 expression and MMP-2 activation in human saphenous vein.
Cardiovascular research 1997;33(2):447-59.
1996: Andrew C Newby; Sarah George
Proliferation, migration, matrix turnover, and death of smooth muscle cells in native coronary and vein graft atherosclerosis.
Current opinion in cardiology 1996;11(6):574-82.
1996: Sarah George; A Williams; Andrew C Newby
An essential role for platelet-derived growth factor in neointima formation in human saphenous vein in vitro.
Atherosclerosis 1996;120(1-2):227-40.
1995: Andrew C Newby; R P Fabunmi; Sarah George; Kay M Southgate; A P Banning; V J Thurston; A Williams
Neointimal fibrosis in vascular pathologies: role of growth factors and metalloproteinases in vascular smooth muscle proliferation.
Experimental nephrology 1995;3(2):108-13.
1993: Andrew C Newby; Sarah George
Proposed roles for growth factors in mediating smooth muscle proliferation in vascular pathologies.
Cardiovascular research 1993;27(7):1173-83.