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Martin Gunthorpe

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U Anand; W R Otto; Paul Facer; Noureddine Zebda; I Selmer; Martin Gunthorpe; Iain P Chessell; M Sinisi; Rolfe Birch; Praveen Anand
TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons.
Martin Gunthorpe; Arpad Szallasi
Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms.
Martin Gunthorpe; Sara Luis Hannan; Darren Smart; Jeffrey C Jerman; Sandra Arpino; Graham D Smith; Stephen J Brough; Jim Wright; Julie Egerton; Sarah C Lappin; Vicky Holland; Kim Y Winborn; Mervyn Thompson; Harshad K Rami; Andrew Randall; John B Davis
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.

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All Publications

2008: U Anand; W R Otto; Paul Facer; Noureddine Zebda; I Selmer; Martin Gunthorpe; Iain P Chessell; M Sinisi; Rolfe Birch; Praveen Anand
TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons.
Neuroscience letters 2008;438(2):221-7.
2008: Martin Gunthorpe; Arpad Szallasi
Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms.
Current pharmaceutical design 2008;14(1):32-41.
2007: Martin Gunthorpe; Sara Luis Hannan; Darren Smart; Jeffrey C Jerman; Sandra Arpino; Graham D Smith; Stephen J Brough; Jim Wright; Julie Egerton; Sarah C Lappin; Vicky Holland; Kim Y Winborn; Mervyn Thompson; Harshad K Rami; Andrew Randall; John B Davis
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1183-92.
2007: Magali Peeters; Martin Gunthorpe; Paul J L M Strijbos; Paul Goldsmith; Neil Upton; Michael F James
Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine.
The Journal of pharmacology and experimental therapeutics 2007;321(2):564-72.
2006: Fumimasa Amaya; Haibin Wang; Michael Costigan; Andrew J Allchorne; Jonathan P Hatcher; Julie Egerton; Tania O Stean; Valerie Morisset; David Grose; Martin Gunthorpe; Iain P Chessell; Simon Tate; Paula J Green; Clifford J Woolf
The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(50):12852-60.
2006: Alex W Wilson; Stephen J Medhurst; Claire I Dixon; Nick C Bontoft; Lisa A Winyard; Kim T Brackenborough; Jorge De Alba; Christopher J Clarke; Martin Gunthorpe; Gareth Hicks; Chas Bountra; Daniel S McQueen; Iain P Chessell
An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.
European journal of pain (London, England) 2006;10(6):537-49.
2006: Sarah C Lappin; Andrew D Randall; Martin Gunthorpe; Valerie Morisset
TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation.
European journal of pharmacology 2006;540(1-3):73-81.
2006: Harshad K Rami; Mervyn Thompson; Geoffrey Stemp; Steve Fell; Jeffrey C Jerman; Alexander J Stevens; Darren Smart; Becky Sargent; Dominic Sanderson; Andrew D Randall; Martin Gunthorpe; John B Davis
Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Bioorganic & medicinal chemistry letters 2006;16(12):3287-91.
2005: Annette Weil; Stephen E Moore; Nicola J Waite; Andrew Randall; Martin Gunthorpe
Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.
Molecular pharmacology 2005;68(2):518-27.
2005: Fergal N McNamara; Andrew Randall; Martin Gunthorpe
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1).
British journal of pharmacology 2005;144(6):781-90.
2004: Harshad K Rami; Mervyn Thompson; Paul A Wyman; Jeffrey C Jerman; Julie Egerton; Stephen J Brough; Alexander J Stevens; Andrew D Randall; Darren Smart; Martin Gunthorpe; John B Davis
Discovery of small molecule antagonists of TRPV1.
Bioorganic & medicinal chemistry letters 2004;14(14):3631-4.
2004: Martin Gunthorpe; Harshad K Rami; Jeffrey C Jerman; Darren Smart; Catherine H Gill; Ellen M Soffin; S Luis Hannan; Sarah C Lappin; Julie Egerton; Graham D Smith; Angela Worby; L Howett; D Owen; S Nasir; Ceri H Davies; Mervyn Thompson; Paul A Wyman; Andrew D Randall; John B Davis
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist.
Neuropharmacology 2004;46(1):133-49.
2003: Christopher D Benham; Martin Gunthorpe; John B Davis
TRPV channels as temperature sensors.
Cell calcium 2003;33(5-6):479-87.
2002: Graham D Smith; Martin Gunthorpe; Rosemary E Kelsell; PD Hayes; P Reilly; Paul Facer; J E Wright; Jeffrey C Jerman; J-P Walhin; L Ooi; Julie Egerton; K J Charles; Darren Smart; Andrew D Randall; Praveen Anand; John B Davis
TRPV3 is a temperature-sensitive vanilloid receptor-like protein.
Nature 2002;418(6894):186-90.
2002: Marcello Trevisani; Darren Smart; Martin Gunthorpe; Michele Tognetto; M Barbieri; Barbara Campi; Silvia Amadesi; J Gray; Jeffrey C Jerman; Stephen J Brough; D Owen; G D Smith; Andrew D Randall; Selena Harrison; A Bianchi; John B Davis; Pierangelo Geppetti
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1.
Nature neuroscience 2002;5(6):546-51.
2002: Martin Gunthorpe; Christopher D Benham; Andrew Randall; John B Davis
The diversity in the vanilloid (TRPV) receptor family of ion channels.
Trends in pharmacological sciences 2002;23(4):183-91.
2001: Martin Gunthorpe; G D Smith; John B Davis; Andrew D Randall
Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells.
Pflügers Archiv : European journal of physiology 2001;442(5):668-74.
2001: Martin Gunthorpe; Sarah C R Lummis
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
The Journal of biological chemistry 2001;276(24):10977-83.
2001: Darren Smart; Jeffrey C Jerman; Martin Gunthorpe; Stephen J Brough; J Ranson; William Cairns; PD Hayes; Andrew D Randall; John B Davis
Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology.
European journal of pharmacology 2001;417(1-2):51-8.
2001: Martin Gunthorpe; Sarah C R Lummis
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
The Journal of biological chemistry 2001;276(14):10977-83.
2000: P Hayes; Helen J Meadows; Martin Gunthorpe; Mark H Harries; DM Duckworth; William Cairns; David C Harrison; Catherine E Clarke; K Ellington; Rab Prinjha; A J Barton; Andrew D Medhurst; G D Smith; S Topp; Paul R Murdock; GJ Sanger; JA Terrett; O Jenkins; Christopher D Benham; Andrew D Randall; IS Gloger; John B Davis
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.
Pain 2000;88(2):205-15.
2000: Martin Gunthorpe; Mark H Harries; Rab Prinjha; John B Davis; Andrew Randall
Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1).
The Journal of physiology 2000;525 Pt 3():747-59.
2000: J R Mellor; Martin Gunthorpe; Andrew D Randall
The taurine uptake inhibitor guanidinoethyl sulphonate is an agonist at gamma-aminobutyric acid(A) receptors in cultured murine cerebellar granule cells.
Neuroscience letters 2000;286(1):25-8.
2000: John B Davis; J Gray; Martin Gunthorpe; Jonathan P Hatcher; Philip T Davey; Philip Overend; Mark H Harries; JK Latcham; C Clapham; K Atkinson; S A Hughes; K Rance; Evelyn Grau; Alex J Harper; Perdita L Pugh; Derek C Rogers; Sharon Bingham; Andrew Randall; S A Sheardown
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.
Nature 2000;405(6783):183-7.
2000: Martin Gunthorpe; J A Peters; Catherine H Gill; J J Lambert; Sarah C R Lummis
The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors.
The Journal of physiology 2000;522 Pt 2():187-98.
2000: Darren Smart; Martin Gunthorpe; Jeffrey C Jerman; S Nasir; J Gray; Alison I Muir; Jon K Chambers; Andrew D Randall; John B Davis
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1).
British journal of pharmacology 2000;129(2):227-30.
1999: Martin Gunthorpe; Sarah C R Lummis
Diltiazem causes open channel block of recombinant 5-HT3 receptors.
The Journal of physiology 1999;519 Pt 3():713-22.
1996: A C Hargreaves; Martin Gunthorpe; Colin W Taylor; Sarah C R Lummis
Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels.
Molecular pharmacology 1996;50(5):1284-94.