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pierre escoubas

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Francesca Marcon; pierre escoubas; Andis Graudins; Peter G Hains; Louise Purtell; Jerran Santos; Graham M Nicholson
Characterization of monomeric and multimeric snake neurotoxins and other bioactive proteins from the venom of the lethal Australian common copperhead (Austrelaps superbus).
Alexandre Palagi; David Wilson; Sébastien Dutertre; Glenn F King; Jennifer M S Koh; Mathieu Leblanc; Graham M Nicholson; pierre escoubas
Unravelling the complex venom landscapes of lethal Australian funnel-web spiders (Hexathelidae: Atracinae) using LC-MALDI-TOF mass spectrometry.
Francesca Marcon; pierre escoubas; Mathieu Leblanc; Richard J Lewis; Irina Vetter; Graham M Nicholson
Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors.

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All Publications

2013: Francesca Marcon; pierre escoubas; Andis Graudins; Peter G Hains; Louise Purtell; Jerran Santos; Graham M Nicholson
Characterization of monomeric and multimeric snake neurotoxins and other bioactive proteins from the venom of the lethal Australian common copperhead (Austrelaps superbus).
Biochemical pharmacology 2013;85(10):1555-73.
2013: Alexandre Palagi; David Wilson; Sébastien Dutertre; Glenn F King; Jennifer M S Koh; Mathieu Leblanc; Graham M Nicholson; pierre escoubas
Unravelling the complex venom landscapes of lethal Australian funnel-web spiders (Hexathelidae: Atracinae) using LC-MALDI-TOF mass spectrometry.
Journal of proteomics 2013;80():292-310.
2012: Francesca Marcon; pierre escoubas; Mathieu Leblanc; Richard J Lewis; Irina Vetter; Graham M Nicholson
Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors.
Biochemical pharmacology 2012;84(6):851-63.
2011: Monique J Windley; Stella M Valenzuela; pierre escoubas; Graham M Nicholson
A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus.
Molecular pharmacology 2011;80(1):1-13.
2009: pierre escoubas; Glenn F King
Venomics as a drug discovery platform.
Expert review of proteomics 2009;6(3):221-4.
2009: David L A Wood; Tomas Miljenović; Shuzhi Cai; Robert J Raven; Quentin Kaas; pierre escoubas; Volker Herzig; David Wilson; Glenn F King
ArachnoServer: a database of protein toxins from spiders.
BMC genomics 2009;10():375.
2008: Glenn F King; Margaret C Gentz; pierre escoubas; Graham M Nicholson
A rational nomenclature for naming peptide toxins from spiders and other venomous animals.
Toxicon : official journal of the International Society on Toxinology 2008;52(2):264-76.
2008: Volker Herzig; Ali A Khalife; Youmie Chong; Geoffrey K Isbister; Bart J Currie; Tracey B Churchill; Suzanne Horner; pierre escoubas; Graham M Nicholson; Wayne C Hodgson
Intersexual variations in Northern (Missulena pruinosa) and Eastern (M. bradleyi) mouse spider venom.
Toxicon : official journal of the International Society on Toxinology 2008;51(7):1167-77.
2008: Glenn F King; pierre escoubas; Graham M Nicholson
Peptide toxins that selectively target insect Na(V) and Ca(V) channels.
Channels (Austin, Tex.) 2008;2(2):100-16.
2008: pierre escoubas; L Quinton; G M Nicholson
Venomics: unravelling the complexity of animal venoms with mass spectrometry.
Journal of mass spectrometry : JMS 2008;43(3):279-95.
2007: Michel Mazzuca; Catherine Heurteaux; Abdelkrim Alloui; Sylvie Diochot; Anne Baron; Nicolas Voilley; Nicolas Blondeau; pierre escoubas; Agnès Gélot; Anny Cupo; Andreas Zimmer; Anne M Zimmer; Alain Eschalier; Michel Lazdunski
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
Nature neuroscience 2007;10(8):943-5.
2007: pierre escoubas; Frank Bosmans
Spider peptide toxins as leads for drug development.
Expert opinion on drug discovery 2007;2(6):823-35.
2007: Sylvie Diochot; Miguel SALINAS; Anne Baron; pierre escoubas; Michel Lazdunski
Peptides inhibitors of acid-sensing ion channels.
Toxicon : official journal of the International Society on Toxinology 2007;49(2):271-84.
2006: guillaume sandoz; Susanne Thümmler; Fabrice DUPRAT; Sylvain Feliciangeli; Joëlle Vinh; pierre escoubas; Nicolas Guy; Michel Lazdunski; Florian Lesage
AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels.
The EMBO journal 2006;25(24):5864-72.
2006: pierre escoubas
Molecular diversification in spider venoms: a web of combinatorial peptide libraries.
Molecular diversity 2006;10(4):545-54.
2006: Morgane Rouault; Lachlan D Rash; pierre escoubas; Eric Boilard; James Bollinger; Bruno Lomonte; Thomas Maurin; Carole Guillaume; Stéphane Canaan; Christiane Deregnaucourt; Joseph Schrével; Alain Doglio; José María Gutiérrez; Michel Lazdunski; Michael H Gelb; Gérard Lambeau
Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.
Biochemistry 2006;45(18):5800-16.
2006: pierre escoubas; Brianna L Sollod; Glenn F King
Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach.
Toxicon : official journal of the International Society on Toxinology 2006;47(6):650-63.
2006: pierre escoubas
Mass spectrometry in toxinology: a 21st-century technology for the study of biopolymers from venoms.
Toxicon : official journal of the International Society on Toxinology 2006;47(6):609-13.
2006: Frank Bosmans; Lachlan D Rash; Shunyi Zhu; Sylvie Diochot; Michel Lazdunski; pierre escoubas; Jan Tytgat
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.
Molecular pharmacology 2006;69(2):419-29.
2006: Miguel SALINAS; Lachlan D Rash; Anne Baron; Gérard Lambeau; pierre escoubas; Michel Lazdunski
The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a.
The Journal of physiology 2006;570(Pt 2):339-54.
2005: Benjamin Chagot; pierre escoubas; Sylvie Diochot; Cédric Bernard; Michel Lazdunski; Hervé Darbon
Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels.
Protein science : a publication of the Protein Society 2005;14(8):2003-10.
2005: Gerardo Corzo; pierre escoubas; Villegas Villarreal Elba Crsitina; Izhar Karbat; Dalia Gordon; Michael Gurevitz; Terumi Nakajima; Nicolas Gilles
A spider toxin that induces a typical effect of scorpion alpha-toxins but competes with beta-toxins on binding to insect sodium channels.
Biochemistry 2005;44(5):1542-9.
2004: Stéphanie Jaubert; Jean-Baptiste Laffaire; terence ledger; pierre escoubas; E-Z Amri; Pierre Abad; Marie-Noëlle Rosso
Comparative analysis of two 14-3-3 homologues and their expression pattern in the root-knot nematode Meloidogyne incognita.
International journal for parasitology 2004;34(7):873-80.
2004: Benjamin Chagot; pierre escoubas; Villegas Villarreal Elba Crsitina; Cédric Bernard; Gilles Ferrat; Gerardo Corzo; Michel Lazdunski; Hervé Darbon
Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus.
Protein science : a publication of the Protein Society 2004;13(5):1197-208.
2004: Sylvie Diochot; Anne Baron; Lachlan D Rash; Emmanuel Deval; pierre escoubas; Sabine Scarzello; Miguel SALINAS; Michel Lazdunski
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons.
The EMBO journal 2004;23(7):1516-25.
2004: pierre escoubas; Lachlan D Rash
Tarantulas: eight-legged pharmacists and combinatorial chemists.
Toxicon : official journal of the International Society on Toxinology 2004;43(5):555-74.
2003: Gerardo Corzo; pierre escoubas
Pharmacologically active spider peptide toxins.
Cellular and molecular life sciences : CMLS 2003;60(11):2409-26.
2003: pierre escoubas; Cédric Bernard; Gérard Lambeau; Michel Lazdunski; Hervé Darbon
Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels.
Protein science : a publication of the Protein Society 2003;12(7):1332-43.
2002: pierre escoubas; Sylvie Diochot; Marie-Louise Célérier; Terumi Nakajima; Michel Lazdunski
Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies.
Molecular pharmacology 2002;62(1):48-57.
2002: pierre escoubas; Gerardo Corzo; Brian J Whiteley; Marie-Louise Célérier; Terumi Nakajima
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and high-performance liquid chromatography study of quantitative and qualitative variation in tarantula spider venoms.
Rapid communications in mass spectrometry : RCM 2002;16(5):403-13.
2001: Gerardo Corzo; pierre escoubas; Villegas Villarreal Elba Crsitina; Kevin J Barnham; W He; R S Norton; Terumi Nakajima
Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.
The Biochemical journal 2001;359(Pt 1):35-45.
2000: pierre escoubas; Maria Stankiewicz; T Takaoka; Marcel Pelhate; Régine Romi-Lebrun; FQ Wu; Terumi Nakajima
Sequence and electrophysiological characterization of two insect-selective excitatory toxins from the venom of the Chinese scorpion Buthus martensi.
FEBS letters 2000;483(2-3):175-80.
2000: pierre escoubas; Sylvie Diochot; Gerardo Corzo
Structure and pharmacology of spider venom neurotoxins.
Biochimie 2000;82(9-10):893-907.
2000: Gerardo Corzo; pierre escoubas; Maria Stankiewicz; Marcel Pelhate; C P Kristensen; Terumi Nakajima
Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae).
European journal of biochemistry / FEBS 2000;267(18):5783-95.
2000: pierre escoubas; Jan de Weille; A Lecoq; Sylvie Diochot; Rainer Waldmann; G Champigny; D Moinier; A Ménez; Michel Lazdunski
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
The Journal of biological chemistry 2000;275(33):25116-21.
1999: pierre escoubas; J Chamot-Rooke; Reto Stöcklin; B J Whiteley; Gerardo Corzo; R Genet; Terumi Nakajima
A comparison of matrix-assisted laser desorption/ionization time-of-flight and liquid chromatography electrospray ionization mass spectrometry methods for the analysis of crude tarantula venoms in the Pterinochilus group.
Rapid communications in mass spectrometry : RCM 1999;13(18):1861-8.
1997: Régine Romi-Lebrun; B Lebrun; Marie-France Martin-Eauclaire; M Ishiguro; pierre escoubas; FQ Wu; M Hisada; O Pongs; Terumi Nakajima
Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels.
Biochemistry 1997;36(44):13473-82.
1997: Régine Romi-Lebrun; Marie-France Martin-Eauclaire; pierre escoubas; FQ Wu; B Lebrun; M Hisada; Terumi Nakajima
Characterization of four toxins from Buthus martensi scorpion venom, which act on apamin-sensitive Ca2+-activated K+ channels.
European journal of biochemistry / FEBS 1997;245(2):457-64.
1997: pierre escoubas; Marie-Louise Célérier; Terumi Nakajima
High-performance liquid chromatography matrix-assisted laser desorption/ionization time-of-flight mass spectrometry peptide fingerprinting of tarantula venoms in the genus Brachypelma: chemotaxonomic and biochemical applications.
Rapid communications in mass spectrometry : RCM 1997;11(17):1891-9.
1995: pierre escoubas; M F Palma; Terumi Nakajima
A microinjection technique using Drosophila melanogaster for bioassay-guided isolation of neurotoxins in arthropod venoms.
Toxicon : official journal of the International Society on Toxinology 1995;33(12):1549-55.
1992: Antoni Polanowski; Tadeusz Wilusz; M S Blum; pierre escoubas; J O Schmidt; J Travis
Serine proteinase inhibitor profiles in the hemolymph of a wide range of insect species.
Comparative biochemistry and physiology. B, Comparative biochemistry 1992;102(4):757-60.
1989: Tappey H Jones; M S Blum; pierre escoubas; T M Musthak Ali
Novel pyrrolidines in the venom of the ant Monomorium indicum.
Journal of natural products 1989;52(4):779-84.
1988: M Lemaire; C Lange; M Bazire; P Cassier; J L Clément; pierre escoubas; J J Basselier
Alkaloid venom of European ants in the genus Monomorium. Site of synthesis, identification and quantification.
Experimental biology 1988;48(1):27-40.