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Marilynn vetzel

Research Profile

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TOP 3
Iontcho R Vlahov; Yu Wang; Spencer Hahn; Paul J Kleindl; Joseph A Reddy; Marilynn vetzel; Christopher P Leamon
Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs.
Christopher P Leamon; Joseph A Reddy; Patrick J Klein; Iontcho R Vlahov; Ryan Dorton; Alicia Bloomfield; Melissa Nelson; Elaine Westrick; Nikki Parker; Kristen Bruna; Marilynn vetzel; Mark Gehrke; Jeffrey S Nicoson; Richard A Messmann; Patricia M LoRusso; Edward A Sausville
Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.
Jyothi A. Reddy; Ryan Dorton; Alicia Dawson; Marilynn vetzel; Nikki Parker; Jeffrey S Nicoson; Elaine Westrick; Patrick J Klein; Yu Wang; Iontcho R Vlahov; Christopher P Leamon
In vivo structural activity and optimization studies of folate-tubulysin conjugates.

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All Publications

2011: Iontcho R Vlahov; Yu Wang; Spencer Hahn; Paul J Kleindl; Joseph A Reddy; Marilynn vetzel; Christopher P Leamon
Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs.
Bioorganic & medicinal chemistry letters 2011;21(22):6778-81.
2011: Christopher P Leamon; Joseph A Reddy; Patrick J Klein; Iontcho R Vlahov; Ryan Dorton; Alicia Bloomfield; Melissa Nelson; Elaine Westrick; Nikki Parker; Kristen Bruna; Marilynn vetzel; Mark Gehrke; Jeffrey S Nicoson; Richard A Messmann; Patricia M LoRusso; Edward A Sausville
Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.
The Journal of pharmacology and experimental therapeutics 2011;336(2):336-43.
2009: Jyothi A. Reddy; Ryan Dorton; Alicia Dawson; Marilynn vetzel; Nikki Parker; Jeffrey S Nicoson; Elaine Westrick; Patrick J Klein; Yu Wang; Iontcho R Vlahov; Christopher P Leamon
In vivo structural activity and optimization studies of folate-tubulysin conjugates.
Molecular pharmaceutics 2009;6(5):1518-25.
2008: Christopher P Leamon; Joseph A Reddy; Marilynn vetzel; Ryan Dorton; Elaine Westrick; Nikki Parker; Yu Wang; Iontcho Vlahov
Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue.
Cancer research 2008;68(23):9839-44.
2007: Christopher P Leamon; Joseph A Reddy; Iontcho R Vlahov; Elaine Westrick; Nikki Parker; Jeffrey S Nicoson; Marilynn vetzel
Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145.
International journal of cancer. Journal international du cancer 2007;121(7):1585-92.
2007: Christopher P Leamon; Joseph A Reddy; Iontcho R Vlahov; Elaine Westrick; Alicia Dawson; Ryan Dorton; Marilynn vetzel; Hari Krishna R Santhapuram; Yu Wang
Preclinical antitumor activity of a novel folate-targeted dual drug conjugate.
Molecular pharmaceutics 2007;4(5):659-67.
2007: Joseph A Reddy; Elaine Westrick; Hari K R Santhapuram; Stephen J Howard; Michael L Miller; Marilynn vetzel; Iontcho R Vlahov; Ravi V J Chari; Victor S Goldmacher; Christopher P Leamon
Folate receptor-specific antitumor activity of EC131, a folate-maytansinoid conjugate.
Cancer research 2007;67(13):6376-82.
2007: Joseph A Reddy; Ryan Dorton; Elaine Westrick; Alicia Dawson; Terri Smith; Le-Cun Xu; Marilynn vetzel; Paul J Kleindl; Iontcho R Vlahov; Christopher P Leamon
Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.
Cancer research 2007;67(9):4434-42.
2006: Yingjuan Lu; Le-Cun Xu; Nikki Parker; Elaine Westrick; Joseph A Reddy; Marilynn vetzel; Philip S Low; Christopher P Leamon
Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate-targeted immunotherapy in hapten-immunized mice.
Molecular cancer therapeutics 2006;5(12):3258-67.
2006: Christopher P Leamon; Joseph A Reddy; Iontcho R Vlahov; Paul J Kleindl; Marilynn vetzel; Elaine Westrick
Synthesis and biological evaluation of EC140: a novel folate-targeted vinca alkaloid conjugate.
Bioconjugate chemistry 2006;17(5):1226-32.
2005: Christopher P Leamon; Joseph A Reddy; Iontcho R Vlahov; Marilynn vetzel; Nikki Parker; Jeffrey S Nicoson; Le-Cun Xu; Elaine Westrick
Synthesis and biological evaluation of EC72: a new folate-targeted chemotherapeutic.
Bioconjugate chemistry 2005;16(4):803-11.
2004: Joseph A Reddy; Le-Cun Xu; Nikki Parker; Marilynn vetzel; Christopher P Leamon
Preclinical evaluation of (99m)Tc-EC20 for imaging folate receptor-positive tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(5):857-66.
2002: Christopher P Leamon; Matthew A Parker; Iontcho R Vlahov; Le-Cun Xu; Joseph A Reddy; Marilynn vetzel; Nikki Douglas
Synthesis and biological evaluation of EC20: a new folate-derived, (99m)Tc-based radiopharmaceutical.
Bioconjugate chemistry 2002;13(6):1200-10.