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Michael Boutros

Research Profile

Phenomena

RNA Interference

Chemicals & Drugs

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Publications

TOP 3
Esther E Schmidt; Svetlana Buhlmann; Thomas Horn; Grainne Kerr; Oliver Pelz; Michael Boutros
GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update.
Thomas Horn; Michael Boutros
Design of RNAi reagents for invertebrate model organisms and human disease vectors.
Markus Brechmann; Rebecca Breuer; Felice Frey; Marco Herling; Michael Kiessling; Claus-Detlev Klemke; Peter H Krammer; Thomas Mock; Wolfgang Müller; Dorothee Nickles; Jan P Nicolay; Yvonne Samstag; Guido H Wabnitz; Nicole Weit; Nina Booken; Michael Boutros; Rüdiger Arnold
A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes.

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All Publications

2013: Esther E Schmidt; Svetlana Buhlmann; Thomas Horn; Grainne Kerr; Oliver Pelz; Michael Boutros
GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update.
Nucleic acids research 2013;41(Database issue):D1021-6.
2013: Thomas Horn; Michael Boutros
Design of RNAi reagents for invertebrate model organisms and human disease vectors.
Methods in molecular biology (Clifton, N.J.) 2013;942():315-46.
2012: Markus Brechmann; Rebecca Breuer; Felice Frey; Marco Herling; Michael Kiessling; Claus-Detlev Klemke; Peter H Krammer; Thomas Mock; Wolfgang Müller; Dorothee Nickles; Jan P Nicolay; Yvonne Samstag; Guido H Wabnitz; Nicole Weit; Nina Booken; Michael Boutros; Rüdiger Arnold
A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes.
Immunity 2012;37(4):697-708.
2012: Julia Christina Gross; Varun Chaudhary; Kerstin Bartscherer; Michael Boutros
Active Wnt proteins are secreted on exosomes.
Nature cell biology 2012;14(10):1036-45.
2012: Laura Icardi; Geert Leroux-Roels; Philip Meuleman; Raffaele Mori; Xavier Saelens; Michael Boutros; Karolien De Bosscher; Lode De Cauwer; Sven Eyckerman; Viola Gesellchen; Koen Vercauteren; Judith Verhelst; Jan Tavernier
The Sin3a repressor complex is a master regulator of STAT transcriptional activity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(30):12058-63.
2012: CE Shamu; Stefan Wiemann; Michael Boutros
On target: a public repository for large-scale RNAi experiments.
Nature cell biology 2012;14(2):115.
2011: Andrei Glinka; Ya-Lin Huang; Dierk Ingelfinger; Olga Kazanskaya; Nadine Kirsch; Michael Boutros; Cristina-Maria Cruciat; Christine Dolde; Christof Niehrs
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.
EMBO reports 2011;12(10):1055-61.
2011: Thomas Sandmann; Matthias C Vogg; Michael Boutros; Suthira Owlarn; Kerstin Bartscherer
The head-regeneration transcriptome of the planarian Schmidtea mediterranea.
Genome biology 2011;12(8):R76.
2010: Hannah Müller; David Schmidt; Sandra Steinbrink; Ekaterina Mirgorodskaya; Verena Lehmann; Karin Habermann; Felix Dreher; Niklas Gustavsson; Thomas Kessler; Hans Lehrach; Ralf Herwig; Johan Gobom; Aspasia Ploubidou; Michael Boutros; Bodo M H Lange
Proteomic and functional analysis of the mitotic Drosophila centrosome.
The EMBO journal 2010;29(19):3344-57.
2010: Thomas Horn; Michael Boutros
E-RNAi: a web application for the multi-species design of RNAi reagents--2010 update.
Nucleic acids research 2010;38(Web Server issue):W332-9.
2010: Florian Fuchs; Gregoire Pau; Dominique Kranz; Oleg Sklyar; Christoph Budjan; Sandra Steinbrink; Thomas Horn; Angelika Pedal; Wolfgang Huber; Michael Boutros
Clustering phenotype populations by genome-wide RNAi and multiparametric imaging.
Molecular systems biology 2010;6():370.
2010: Christina Falschlehner; Sandra Steinbrink; Gerrit Erdmann; Michael Boutros
High-throughput RNAi screening to dissect cellular pathways: a how-to guide.
Biotechnology journal 2010;5(4):368-76.
2010: Katarzyna Mleczko-Sanecka; Guillem Casanovas; Anan Ragab; Katja Breitkopf; Alexandra Müller; Michael Boutros; Steven Dooley; Matthias W Hentze; Martina U Muckenthaler
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression.
Blood 2010;115(13):2657-65.
2010: Cristina-Maria Cruciat; Bisei Ohkawara; Sergio P Acebron; Emil Karaulanov; Carmen Reinhard; Dierk Ingelfinger; Michael Boutros; Christof Niehrs
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.
Science (New York, N.Y.) 2010;327(5964):459-63.
2009: Gary Davidson; Jinlong Shen; Ya-Lin Huang; Yi Su; Emil Karaulanov; Kerstin Bartscherer; Christine Hassler; Peter Stannek; Michael Boutros; Christof Niehrs
Cell cycle control of wnt receptor activation.
Developmental cell 2009;17(6):788-99.
2009: A Farfsing; F Engel; M Seiffert; E Hartmann; German Ott; A Rosenwald; Stephan Stilgenbauer; Hartmut Döhner; Michael Boutros; Peter Lichter; Armin Pscherer
Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia.
Leukemia 2009;23(11):2018-26.
2008: Kerstin Bartscherer; Michael Boutros
Regulation of Wnt protein secretion and its role in gradient formation.
EMBO reports 2008;9(10):977-82.
2008: Michael Boutros; Julie Ahringer
The art and design of genetic screens: RNA interference.
Nature reviews. Genetics 2008;9(7):554-66.
2008: Bastian Stielow; Alexandra Sapetschnig; Imme Krüger; Natascha Kunert; Alexander Brehm; Michael Boutros; Guntram Suske
Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen.
Molecular cell 2008;29(6):742-54.
2008: Sandra Steinbrink; Michael Boutros
RNAi screening in cultured Drosophila cells.
Methods in molecular biology (Clifton, N.J.) 2008;420():139-53.
2008: Akira Goto; Kazufumi Matsushita; Viola Gesellchen; Laure El Chamy; David Kuttenkeuler; Osamu Takeuchi; Jules A Hoffmann; Shizuo Akira; Michael Boutros; Jean-Marc Reichhart
Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.
Nature immunology 2008;9(1):97-104.
2007: Ana Eulalio; Jan Rehwinkel; Mona Stricker; Eric Huntzinger; Schu-Fee Yang; Tobias Doerks; Silke Dorner; Peer Bork; Michael Boutros; Elisa Izaurralde
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
Genes & development 2007;21(20):2558-70.
2007: Thomas Horn; Zeynep Arziman; Juerg Berger; Michael Boutros
GenomeRNAi: a database for cell-based RNAi phenotypes.
Nucleic acids research 2007;35(Database issue):D492-7.
2006: Christophe Echeverri; Philip A Beachy; Buzz Baum; Michael Boutros; Frank Buchholz; Sumit K Chanda; Julian Downward; Jan Ellenberg; Andrew G Fraser; Nir Hacohen; William C Hahn; Aimee L Jackson; Amy Kiger; Peter Linsley; Lawrence Lum; Yong Ma; Bernard Mathey-Prévôt; David E Root; David M Sabatini; Jussi Taipale; Norbert Perrimon; René Bernards
Minimizing the risk of reporting false positives in large-scale RNAi screens.
Nature methods 2006;3(10):777-9.
2006: Kerstin Bartscherer; Nadège Pelte; Dierk Ingelfinger; Michael Boutros
Secretion of Wnt ligands requires Evi, a conserved transmembrane protein.
Cell 2006;125(3):523-33.
2006: Florian Fuchs; Michael Boutros
Cellular phenotyping by RNAi.
Briefings in functional genomics & proteomics 2006;5(1):52-6.
2006: Michael Boutros; Lígia P Brás; Wolfgang Huber
Analysis of cell-based RNAi screens.
Genome biology 2006;7(7):R66.
2006: Ian Flockhart; Matthew Booker; Amy Kiger; Michael Boutros; Susan Armknecht; Nadire Ramadan; Kris Richardson; Andrew Xu; Norbert Perrimon; Bernard Mathey-Prevot
FlyRNAi: the Drosophila RNAi screening center database.
Nucleic acids research 2006;34(Database issue):D489-94.
2005: Viola Gesellchen; David Kuttenkeuler; Michael Steckel; Nadège Pelte; Michael Boutros
An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila.
EMBO reports 2005;6(10):979-84.
2005: Patrick Müller; David Kuttenkeuler; Viola Gesellchen; Martin P Zeidler; Michael Boutros
Identification of JAK/STAT signalling components by genome-wide RNA interference.
Nature 2005;436(7052):871-5.
2005: Zeynep Arziman; Thomas Horn; Michael Boutros
E-RNAi: a web application to design optimized RNAi constructs.
Nucleic acids research 2005;33(Web Server issue):W582-8.
2005: Ramanuj Dasgupta; Michael Boutros; Norbert Perrimon
Drosophila Wnt/Fz pathways.
Science's STKE : signal transduction knowledge environment 2005;2005(283):cm5.
2005: Sung E Choe; Michael Boutros; Alan M Michelson; George M Church; Marc S. Halfon
Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset.
Genome biology 2005;6(2):R16.
2005: Susan Armknecht; Michael Boutros; Amy Kiger; Kent Nybakken; Bernard Mathey-Prevot; Norbert Perrimon
High-throughput RNA interference screens in Drosophila tissue culture cells.
Methods in enzymology 2005;392():55-73.
2004: David Kuttenkeuler; Michael Boutros
Genome-wide RNAi as a route to gene function in Drosophila.
Briefings in functional genomics & proteomics 2004;3(2):168-76.
2004: Viola Gesellchen; Michael Boutros
Managing the genome: microRNAs in Drosophila.
Differentiation; research in biological diversity 2004;72(2-3):74-80.
2004: Michael Boutros; Amy Kiger; Susan Armknecht; Kim Kerr; Marc Hild; Britta Koch; Stefan A Haas; Renato Paro; Norbert Perrimon
Genome-wide RNAi analysis of growth and viability in Drosophila cells.
Science (New York, N.Y.) 2004;303(5659):832-5.
2003: Hervé Agaisse; Ulla Maja Petersen; Michael Boutros; Bernard Mathey-Prevot; Norbert Perrimon
Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.
Developmental cell 2003;5(3):441-50.
2003: Marc Hild; Boris Beckmann; Stefan A Haas; Britta Koch; V Solovyev; Christian Busold; Kurt Fellenberg; Michael Boutros; Martin Vingron; F Sauer; Jörg D Hoheisel; Renato Paro
An integrated gene annotation and transcriptional profiling approach towards the full gene content of the Drosophila genome.
Genome biology 2003;5(1):R3.
2002: Michael Boutros; Hervé Agaisse; Norbert Perrimon
Sequential activation of signaling pathways during innate immune responses in Drosophila.
Developmental cell 2002;3(5):711-22.
2002: Randall T Moon; Bruce Bowerman; Michael Boutros; Norbert Perrimon
The promise and perils of Wnt signaling through beta-catenin.
Science (New York, N.Y.) 2002;296(5573):1644-6.
2000: Michael Boutros; J Mihaly; Tewis Bouwmeester; Marek Mlodzik
Signaling specificity by Frizzled receptors in Drosophila.
Science (New York, N.Y.) 2000;288(5472):1825-8.
2000: Michael Boutros; Norbert Perrimon
Drosophila genome takes flight.
Nature cell biology 2000;2(4):E53-4.
1999: Nuria Paricio; Fabian Feiguin; Michael Boutros; Suzanne Eaton; Marek Mlodzik
The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling.
The EMBO journal 1999;18(17):4669-78.
1999: Michael Boutros; Marek Mlodzik
Dishevelled: at the crossroads of divergent intracellular signaling pathways.
Mechanisms of development 1999;83(1-2):27-37.
1998: Michael Boutros; Nuria Paricio; DI Strutt; Marek Mlodzik
Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling.
Cell 1998;94(1):109-18.