Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Kenneth Jacobson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Living Beings

Procedures

Radioligand Assay

Anatomy

Physiology

Competitive Binding

Genes & Molecular Sequences

Molecular Structure

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
73
Gao, Zhan-Guo
37
Harden, Kendall
36
Ji, Xiao-Duo
36
Melman, Neli
33
Stiles, Gary
31
Jeong, Lak Shin
28
Kim, Hea Ok
26
Joshi, Bhalchandra
25
Kim, Soo-Kyung
20
Moro, Stefano
19
Olah, ME
19
Daly, John
17
Chun, Moon Woo
17
Boyer, José
17
Shainberg, Asher

Sign-in to see all Coauthors

Publications

TOP 3
Ko Hyojin; Das Arijit; Carter Rhonda L; Fricks Ingrid P; Zhou Yixing; Ivanov Andrei A; Melman Artem; Joshi Bhalchandra V; Kovác Pavol; Hajduch Jan; Kirk Kenneth L; Harden T Kendall; Jacobson Kenneth A
Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.
Cosyn Liesbet; Van Calenbergh Serge; Joshi Bhalchandra V; Ko Hyojin; Carter Rhonda L; Kendall Harden T; Jacobson Kenneth A
Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.
Ivanov Andrei A; Barak Dov; Jacobson Kenneth A
Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Kenneth Jacobson (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Ko Hyojin; Das Arijit; Carter Rhonda L; Fricks Ingrid P; Zhou Yixing; Ivanov Andrei A; Melman Artem; Joshi Bhalchandra V; Kovác Pavol; Hajduch Jan; Kirk Kenneth L; Harden T Kendall; Jacobson Kenneth A
Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.
Bioorganic & medicinal chemistry 2009;17(14):5298-311.
2009: Cosyn Liesbet; Van Calenbergh Serge; Joshi Bhalchandra V; Ko Hyojin; Carter Rhonda L; Kendall Harden T; Jacobson Kenneth A
Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.
Bioorganic & medicinal chemistry letters 2009;19(11):3002-5.
2009: Ivanov Andrei A; Barak Dov; Jacobson Kenneth A
Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure.
Journal of medicinal chemistry 2009;52(10):3284-92.
2009: Pal Shantanu; Choi Won Jun; Choe Seung Ah; Heller Cara L; Gao Zhan-Guo; Chinn Moshe; Jacobson Kenneth A; Hou Xiyan; Lee Sang Kook; Kim Hea Ok; Jeong Lak Shin
Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2009;17(10):3733-8.
2009: Shainberg Asher; Yitzhaki Smadar; Golan Or; Jacobson Kenneth A; Hochhauser Edith
Involvement of UTP in protection of cardiomyocytes from hypoxic stress.
Canadian journal of physiology and pharmacology 2009;87(4):287-99.
2009: Kim Yoonkyung; de Castro Sonia; Gao Zhan-Guo; Ijzerman Adriaan P; Jacobson Kenneth A
Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor.
Journal of medicinal chemistry 2009;52(7):2098-108.
2009: Diaz Juan Carlos; Simakova Olga; Jacobson Kenneth A; Arispe Nelson; Pollard Harvey B
Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3348-53.
2009: Jacobson Kenneth A; Zablocki Jeff; Bhagwat Shripad
Preface: special issue on medicinal chemistry of purines.
Purinergic signalling 2009;5(1):1.
2009: Jacobson Kenneth A; Ivanov Andrei A; de Castro Sonia; Harden T Kendall; Ko Hyojin
Development of selective agonists and antagonists of P2Y receptors.
Purinergic signalling 2009;5(1):75-89.
2009: Kim Yoonkyung; Klutz Athena M; Hechler Béatrice; Gao Zhan-Guo; Gachet Christian; Jacobson Kenneth A
Application of the functionalized congener approach to dendrimer-based signaling agents acting through A(2A) adenosine receptors.
Purinergic signalling 2009;5(1):39-50.
2009: Gao Zhan-Guo; Teng Bao; Wu Haitao; Joshi Bhalchandra V; Griffiths Gary L; Jacobson Kenneth A
Synthesis and pharmacological characterization of [(125)I]MRS1898, a high-affinity, selective radioligand for the rat A(3) adenosine receptor.
Purinergic signalling 2009;5(1):31-7.
2009: Kiesewetter Dale O; Lang Lixin; Ma Ying; Bhattacharjee Abesh Kumar; Gao Zhan-Guo; Joshi Bhalchandra V; Melman Artem; de Castro Sonia; Jacobson Kenneth A
Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography.
Nuclear medicine and biology 2009;36(1):3-10.
2009: Jacobson Kenneth A; Klutz Athena M; Tosh Dilip K; Ivanov Andrei A; Preti Delia; Baraldi Pier Giovanni
Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.
Handbook of experimental pharmacology 2009;(193):123-59.
2009: Jacobson Kenneth A
Introduction to adenosine receptors as therapeutic targets.
Handbook of experimental pharmacology 2009;(193):1-24.
2008: Wess Jürgen; Han Sung-Jun; Kim Soo-Kyung; Jacobson Kenneth A; Li Jian Hua
Conformational changes involved in G-protein-coupled-receptor activation.
Trends in pharmacological sciences 2008;29(12):616-25.
2008: Ohtani Masahiro; Suzuki Jun-Ichiro; Jacobson Kenneth A; Oka Takami
Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and insulin secretion in mouse pancreatic islets.
Purinergic signalling 2008;4(4):365-75.
2008: Melman Artem; Zhong Minghong; Marquez Victor E; Jacobson Kenneth A
Synthesis of enantiomerically pure (S)-methanocarbaribo uracil nucleoside derivatives for use as antiviral agents and P2Y receptor ligands.
The Journal of organic chemistry 2008;73(20):8085-8.
2008: Jeong Lak Shin; Pal Shantanu; Choe Seung Ah; Choi Won Jun; Jacobson Kenneth A; Gao Zhan-Guo; Klutz Athena M; Hou Xiyan; Kim Hea Ok; Lee Hyuk Woo; Lee Sang Kook; Tosh Dilip K; Moon Hyung Ryong
Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2008;51(20):6609-13.
2008: Roh Eun Joo; Keller Jason M; Olah Zoltan; Iadarola Michael J; Jacobson Kenneth A
Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1).
Bioorganic & medicinal chemistry 2008;16(20):9349-58.
2008: Mamedova Liaman K; Wang Ruibo; Besada Pedro; Liang Bruce T; Jacobson Kenneth A
Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.
Pharmacological research : the official journal of the Italian Pharmacological Society 2008;58(3-4):232-9.
2008: Melman Artem; Wang Ben; Joshi Bhalchandra V; Gao Zhan-Guo; Castro Sonia de; Heller Cara L; Kim Soo-Kyung; Jeong Lak Shin; Jacobson Kenneth A
Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.
Bioorganic & medicinal chemistry 2008;16(18):8546-56.
2008: Sonin Dmitry; Zhou Si-Yuan; Cronin Chunxia; Sonina Tatiana; Wu Jeffrey; Jacobson Kenneth A; Pappano Achilles; Liang Bruce T
Role of P2X purinergic receptors in the rescue of ischemic heart failure.
American journal of physiology. Heart and circulatory physiology 2008;295(3):H1191-H1197.
2008: Matot Idit; Einav Sharon; Weiniger Carolyn F; Pearl Ron G; Abramovitch Rinat; Joshi Balachandra V; Jacobson Kenneth A
Lung injury after in vivo reperfusion: outcome at 27 hours after reperfusion.
Anesthesiology 2008;109(2):269-78.
2008: Ivanov Andrei A; Jacobson Kenneth A
Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A2A adenosine receptor homodimer.
Bioorganic & medicinal chemistry letters 2008;18(15):4312-5.
2008: Kim Yoonkyung; Klutz Athena M; Jacobson Kenneth A
Systematic investigation of polyamidoamine dendrimers surface-modified with poly(ethylene glycol) for drug delivery applications: synthesis, characterization, and evaluation of cytotoxicity.
Bioconjugate chemistry 2008;19(8):1660-72.
2008: Brand Frank; Klutz Athena M; Jacobson Kenneth A; Fredholm Bertil B; Schulte Gunnar
Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.
European journal of pharmacology 2008;590(1-3):36-42.
2008: Ochaion A; Bar-Yehuda S; Cohen S; Amital H; Jacobson K A; Joshi B V; Gao Z G; Barer F; Patoka R; Del Valle L; Perez-Liz G; Fishman P
The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats.
Biochemical pharmacology 2008;76(4):482-94.
2008: Houston Dayle; Costanzi Stefano; Jacobson Kenneth A; Harden T Kendall
Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.
Combinatorial chemistry & high throughput screening 2008;11(6):410-9.
2008: Ko Hyojin; Carter Rhonda L; Cosyn Liesbet; Petrelli Riccardo; de Castro Sonia; Besada Pedro; Zhou Yixing; Cappellacci Loredana; Franchetti Palmarisa; Grifantini Mario; Van Calenbergh Serge; Harden T Kendall; Jacobson Kenneth A
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
Bioorganic & medicinal chemistry 2008;16(12):6319-32.
2008: Melman Artem; Gao Zhan-Guo; Kumar Deepmala; Wan Tina C; Gizewski Elizabeth; Auchampach John A; Jacobson Kenneth A
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.
Bioorganic & medicinal chemistry letters 2008;18(9):2813-9.
2008: Fricks Ingrid P; Maddileti Savitri; Carter Rhonda L; Lazarowski Eduardo R; Nicholas Robert A; Jacobson Kenneth A; Harden T Kendall
UDP is a competitive antagonist at the human P2Y14 receptor.
The Journal of pharmacology and experimental therapeutics 2008;325(2):588-94.
2008: Gao Zhan-Guo; Jacobson Kenneth A
Translocation of arrestin induced by human A(3) adenosine receptor ligands in an engineered cell line: comparison with G protein-dependent pathways.
Pharmacological research : the official journal of the Italian Pharmacological Society 2008;57(4):303-11.
2008: Chun Moon Woo; Choi Sung Wook; Kang Tae Kyung; Choi Won Jun; Kim Hea Ok; Gao Zhan-Guo; Jacobson Kenneth A; Jeong Lak Shin
Synthesis of 3'-acetamidoadenosine derivatives as potential A3 adenosine receptor agonists.
Nucleosides, nucleotides & nucleic acids 2008;27(4):408-20.
2008: Ivanov Andrei A; Wang Ben; Klutz Athena M; Chen Vincent L; Gao Zhan-Guo; Jacobson Kenneth A
Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists.
Journal of medicinal chemistry 2008;51(7):2088-99.
2008: Joshi Bhalchandra V; Melman Artem; Mackman Richard L; Jacobson Kenneth A
Synthesis of ethyl (1S,2R,3S,4S,5S)-2,3-O-(isopropylidene)-4-hydroxy-bicyclo[3.1.0]hexane-carboxylate from L-ribose: a versatile chiral synthon for preparation of adenosine and P2 receptor ligands.
Nucleosides, nucleotides & nucleic acids 2008;27(3):279-91.
2008: Jeong Lak Shin; Lee Hyuk Woo; Kim Hea Ok; Tosh Dilip K; Pal Shantanu; Choi Won Jun; Gao Zhan-Guo; Patel Amit R; Williams Wanda; Jacobson Kenneth A; Kim Hee-Doo
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry letters 2008;18(5):1612-6.
2008: Li Jian Hua; Hamdan Fadi F; Kim Soo-Kyung; Jacobson Kenneth A; Zhang Xiaohong; Han Sung-Jun; Wess Jürgen
Ligand-specific changes in M3 muscarinic acetylcholine receptor structure detected by a disulfide scanning strategy.
Biochemistry 2008;47(9):2776-88.
2008: Gao Zhan-Guo; Hechler Béatrice; Besada Pedro; Gachet Christian; Jacobson Kenneth A
Caged agonist of P2Y1 and P2Y12 receptors for light-directed facilitation of platelet aggregation.
Biochemical pharmacology 2008;75(6):1341-7.
2008: Kim Yoonkyung; Hechler Béatrice; Klutz Athena M; Gachet Christian; Jacobson Kenneth A
Toward multivalent signaling across G protein-coupled receptors from poly(amidoamine) dendrimers.
Bioconjugate chemistry 2008;19(2):406-11.
2008: Lee Ga Eun; Joshi Bhalchandra V; Chen Wangzhong; Jeong Lak Shin; Moon Hyung Ryong; Jacobson Kenneth A; Kim Yong-Chul
Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor.
Bioorganic & medicinal chemistry letters 2008;18(2):571-5.
2008: Gao Zhan-Guo; Ye Kai; Göblyös Anikó; Ijzerman Adriaan P; Jacobson Kenneth A
Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000.
BMC pharmacology 2008;8():20.
2008: Klutz Athena M; Gao Zhan-Guo; Lloyd John; Shainberg Asher; Jacobson Kenneth A
Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates.
Journal of nanobiotechnology 2008;6():12.
2008: Choi Won Jun; Lee Hyuk Woo; Hou Xiyan; Kim Hea O K; Jacobson Kenneth A; Jeong Lak Shin
Synthesis of 2-chloro-N6-substituted-4'-thioadenosine-5'-N, N-dialkyluronamides as potent and selective A3 adenosine receptor antagonists.
Nucleic acids symposium series (2004) 2008;(52):645-6.
2008: Hou Xiyan; Pal Shantanu; Choi Won Jun; Kim Hea Ok; Tipnis Amol; Jacobson Kenneth A; Jeong Lak Shin
Design and synthesis of truncated 4'-thioadenosine derivatives as potent and selective A3 adenosine receptor antagonists.
Nucleic acids symposium series (2004) 2008;(52):641-2.
2007: Zheng Jingang; Wang Rubio; Zambraski Edward; Wu Dan; Jacobson Kenneth A; Liang Bruce T
Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.
American journal of physiology. Heart and circulatory physiology 2007;293(6):H3685-91.
2007: Olivecrona Goran K; Götberg Matthias; Harnek Jan; Jacobson Kenneth A; Jern Sverker; Erlinge David
The ADP receptor P2Y(1) mediates t-PA release in pigs during cardiac ischemia.
Journal of thrombosis and thrombolysis 2007;24(2):115-22.
2007: Gao Zhan-Guo; Jacobson Kenneth A
Emerging adenosine receptor agonists.
Expert opinion on emerging drugs 2007;12(3):479-92.
2007: Pugliese Anna Maria; Coppi Elisabetta; Volpini Rosaria; Cristalli Gloria; Corradetti Renato; Jeong Lak Shin; Jacobson Kenneth A; Pedata Felicita
Role of adenosine A3 receptors on CA1 hippocampal neurotransmission during oxygen-glucose deprivation episodes of different duration.
Biochemical pharmacology 2007;74(5):768-79.
2007: Li Jian Hua; Han Sung-Jun; Hamdan Fadi F; Kim Soo-Kyung; Jacobson Kenneth A; Bloodworth Lanh M; Zhang Xiaohong; Wess Jürgen
Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands.
The Journal of biological chemistry 2007;282(36):26284-93.
2007: Costanzi Stefano; Tikhonova Irina G; Ohno Michihiro; Roh Eun Joo; Joshi Bhalchandra V; Colson Anny-Odile; Houston Dayle; Maddileti Savitri; Harden T Kendall; Jacobson Kenneth A
P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring.
Journal of medicinal chemistry 2007;50(14):3229-41.
2007: Jeong Lak Shin; Choe Seung Ah; Gunaga Prashantha; Kim Hea Ok; Lee Hyuk Woo; Lee Sang Kook; Tosh Dilip K; Patel Amit; Palaniappan Krishnan K; Gao Zhan-Guo; Jacobson Kenneth A; Moon Hyung Ryong
Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.
Journal of medicinal chemistry 2007;50(14):3159-62.
2007: Wang Zhao; Do Chi Wai; Avila Marcel Y; Stone Richard A; Jacobson Kenneth A; Civan Mortimer M
Barrier qualities of the mouse eye to topically applied drugs.
Experimental eye research 2007;85(1):105-12.
2007: Palaniappan Krishnan K; Gao Zhan-Guo; Ivanov Andrei A; Greaves Rebecca; Adachi Hayamitsu; Besada Pedro; Kim Hea Ok; Kim Ae Yil; Choe Seung Ah; Jeong Lak Shin; Jacobson Kenneth A
Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides.
Biochemistry 2007;46(25):7437-48.
2007: Ko Hyojin; Fricks Ingrid; Ivanov Andrei A; Harden T Kendall; Jacobson Kenneth A
Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor.
Journal of medicinal chemistry 2007;50(9):2030-9.
2007: Kimand Soo-Kyung; Jacobson Kenneth A
Three-dimensional quantitative structure-activity relationship of nucleosides acting at the A3 adenosine receptor: analysis of binding and relative efficacy.
Journal of chemical information and modeling 2007;47(3):1225-33.
2007: Koizumi Schuichi; Shigemoto-Mogami Yukari; Nasu-Tada Kaoru; Shinozaki Yoichi; Ohsawa Keiko; Tsuda Makoto; Joshi Bhalchandra V; Jacobson Kenneth A; Kohsaka Shinichi; Inoue Kazuhide
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.
Nature 2007;446(7139):1091-5.
2007: Adachi Hayamitsu; Palaniappan Krishnan K; Ivanov Andrei A; Bergman Nathaniel; Gao Zhan-Guo; Jacobson Kenneth A
Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor.
Journal of medicinal chemistry 2007;50(8):1810-27.
2007: Ivanov Andrei A; Ko Hyojin; Cosyn Liesbet; Maddileti Savitri; Besada Pedro; Fricks Ingrid; Costanzi Stefano; Harden T Kendall; Calenbergh Serge Van; Jacobson Kenneth A
Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.
Journal of medicinal chemistry 2007;50(6):1166-76.
2007: Jacobson Kenneth A; Gao Zhan-Guo; Liang Bruce T
Neoceptors: reengineering GPCRs to recognize tailored ligands.
Trends in pharmacological sciences 2007;28(3):111-6.
2007: Li Bo; Scarselli Marco; Knudsen Christopher D; Kim Soo-Kyung; Jacobson Kenneth A; McMillin Sara M; Wess Jürgen
Rapid identification of functionally critical amino acids in a G protein-coupled receptor.
Nature methods 2007;4(2):169-74.
2007: Ivanov Andrei A; Fricks Ingrid; Kendall Harden T; Jacobson Kenneth A
Molecular dynamics simulation of the P2Y14 receptor. Ligand docking and identification of a putative binding site of the distal hexose moiety.
Bioorganic & medicinal chemistry letters 2007;17(3):761-6.
2007: Shen Jian-Bing; Cronin Chunxia; Sonin Dmitry; Joshi Bhalchandra V; Gongora Nieto Maria; Harrison David; Jacobson Kenneth A; Liang Bruce T
P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure.
American journal of physiology. Heart and circulatory physiology 2007;292(2):H1077-84.
2007: Jeong Lak Shin; Choe Seung Ah; Kim Ae Yil; Kim Hea Ok; Gao Zhan-Guo; Jacobson Kenneth A; Chun Moon Woo; Moon Hyung Ryong
Synthesis of N6-substituted 3'-ureidoadenosine derivatives as highly potent agonists at the mutant A3 adenosine receptor.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):717-9.
2007: Jeong Lak Shin; Lee Hyuk Woo; Kim Hea Ok; Jung Ji Young; Gunaga Prashantha; Lee Sang Kook; Lee Eun-Jin; Chun Moon Woo; Gao Zhan-Guo; Jacobson Kenneth A; Moon Hyung Ryong
Design, synthesis, and anti-tumor activity of 4'-thionucleosides as potent and selective agonists at the human A3 adenosine receptor.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1565-8.
2007: Jeong Lak Shin; Gunaga Prashantha; Kim Hea Ok; Tosh Dilip K; Lee Hyuk Woo; Choe Seung Ah; Moon Hyung Ryong; Gao Zhan-Guo; Jacobson Kenneth A; Chun Moon Woo
Stereoselective synthesis of 1'-functionalized-4'-thionucleosides.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1011-4.
2006: Cosyn Liesbet; Palaniappan Krishnan K; Kim Soo-Kyung; Duong Heng T; Gao Zhan-Guo; Jacobson Kenneth A; Van Calenbergh Serge
2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.
Journal of medicinal chemistry 2006;49(25):7373-83.
2006: Kim Soo-Kyung; Gao Zhan-Guo; Jeong Lak Shin; Jacobson Kenneth A
Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor.
Journal of molecular graphics & modelling 2006;25(4):562-77.
2006: Kim Soo-Kyung; Jacobson Kenneth A
Computational prediction of homodimerization of the A3 adenosine receptor.
Journal of molecular graphics & modelling 2006;25(4):549-61.
2006: Yitzhaki Smadar; Shainberg Asher; Cheporko Yelena; Vidne Bernardo A; Sagie Alex; Jacobson Kenneth A; Hochhauser Edith
Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function after myocardial infarct.
Biochemical pharmacology 2006;72(8):949-55.
2006: Mamedova Liaman K; Gao Zhan-Guo; Jacobson Kenneth A
Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors.
Biochemical pharmacology 2006;72(8):1031-41.
2006: Abbracchio Maria P; Burnstock Geoffrey; Boeynaems Jean-Marie; Barnard Eric A; Boyer José L; Kennedy Charles; Knight Gillian E; Fumagalli Marta; Gachet Christian; Jacobson Kenneth A; Weisman Gary A
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.
Pharmacological reviews 2006;58(3):281-341.
2006: Besada Pedro; Shin Dae Hong; Costanzi Stefano; Ko Hyojin; Mathé Christophe; Gagneron Julien; Gosselin Gilles; Maddileti Savitri; Harden T Kendall; Jacobson Kenneth A
Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.
Journal of medicinal chemistry 2006;49(18):5532-43.
2006: Ivanov Andrei A; Costanzi Stefano; Jacobson Kenneth A
Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling.
Journal of computer-aided molecular design 2006;20(7-8):417-26.
2006: Hu Jianxin; Jiang Jiankang; Costanzi Stefano; Thomas Craig; Yang Wu; Feyen Jean H M; Jacobson Kenneth A; Spiegel Allen M
A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator.
The Journal of biological chemistry 2006;281(30):21558-65.
2006: Jeong Lak Shin; Lee Hyuk Woo; Kim Hea Ok; Jung Ji Young; Gao Zhan-Guo; Duong Heng T; Rao Srikar; Jacobson Kenneth A; Shin Dae Hong; Lee Jeong A; Gunaga Prashantha; Lee Sang Kook; Jin Dong Zhe; Chun Moon Woo; Moon Hyung Ryong
Design, synthesis, and biological activity of N6-substituted-4'-thioadenosines at the human A3 adenosine receptor.
Bioorganic & medicinal chemistry 2006;14(14):4718-30.
2006: Göblyös Anikó; Gao Zhan-Guo; Brussee Johannes; Connestari Roberto; Santiago Sabrina Neves; Ye Kai; Ijzerman Adriaan P; Jacobson Kenneth A
Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor.
Journal of medicinal chemistry 2006;49(11):3354-61.
2006: Gao Zhan-Guo; Duong Heng T; Sonina Tatiana; Kim Soo-Kyung; Van Rompaey Philippe; Van Calenbergh Serge; Mamedova Liaman; Kim Hea Ok; Kim Myong Jung; Kim Ae Yil; Liang Bruce T; Jeong Lak Shin; Jacobson Kenneth A
Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.
Journal of medicinal chemistry 2006;49(9):2689-702.
2006: Bourdon D M; Mahanty S K; Jacobson K A; Boyer J L; Harden T K
(N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets.
Journal of thrombosis and haemostasis : JTH 2006;4(4):861-8.
2006: Wihlborg Anna-Karin; Balogh Johanna; Wang Lingwei; Borna Catharina; Dou Ying; Joshi Bhalchandra V; Lazarowski Eduardo; Jacobson Kenneth A; Arner Anders; Erlinge David
Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction.
Circulation research 2006;98(7):970-6.
2006: Gao Zhan-Guo; Jacobson Kenneth A
Keynote review: allosterism in membrane receptors.
Drug discovery today 2006;11(5-6):191-202.
2006: Jacobson Kenneth A; Gao Zhan-Guo
Adenosine receptors as therapeutic targets.
Nature reviews. Drug discovery 2006;5(3):247-64.
2006: Moro Stefano; Gao Zhan-Guo; Jacobson Kenneth A; Spalluto Giampiero
Progress in the pursuit of therapeutic adenosine receptor antagonists.
Medicinal research reviews 2006;26(2):131-59.
2006: Houston Dayle; Ohno Michihiro; Nicholas Robert A; Jacobson Kenneth A; Harden T Kendall
[32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors.
British journal of pharmacology 2006;147(5):459-67.
2006: Cosyn Liesbet; Gao Zhan-Guo; Van Rompaey Philippe; Lu Changrui; Jacobson Kenneth A; Van Calenbergh Serge
Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands.
Bioorganic & medicinal chemistry 2006;14(5):1403-12.
2006: Jacobson Kenneth A; Costanzi Stefano; Ivanov Andrei A; Tchilibon Susanna; Besada Pedro; Gao Zhan-Guo; Maddileti Savitri; Harden T Kendall
Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors.
Biochemical pharmacology 2006;71(4):540-9.
2006: Gao Zhan-Guo; Joshi Bhalchandra V; Klutz Athena M; Kim Soo-Kyung; Lee Hyuk Woo; Kim Hea Ok; Jeong Lak Shin; Jacobson Kenneth A
Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.
Bioorganic & medicinal chemistry letters 2006;16(3):596-601.
2006: Hechler Béatrice; Nonne Christelle; Roh Eun Joo; Cattaneo Marco; Cazenave Jean-Pierre; Lanza François; Jacobson Kenneth A; Gachet Christian
MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice.
The Journal of pharmacology and experimental therapeutics 2006;316(2):556-63.
2006: Jeong Lak Shin; Lee Hyuk Woo; Jacobson Kenneth A; Kim Hea Ok; Shin Dae Hong; Lee Jeong A; Gao Zhan-Guo; Lu Changrui; Duong Heng T; Gunaga Prashantha; Lee Sang Kook; Jin Dong Zhe; Chun Moon Woo; Moon Hyung Ryong
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.
Journal of medicinal chemistry 2006;49(1):273-81.
2006: Jacobson Kenneth A; Costanzi Stefano; Kim Soo-Kyung; Roh Eunjoo; Joshi Bhalchandra V; Tchilibon Susanna; Duong Heng T; Gao Zhan-Guo
Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors.
Nucleosides, nucleotides & nucleic acids 2006;25(12):1425-36.
2006: Jacobson Kenneth A; Costanzi Stefano; Joshi Bhalchandra V; Besada Pedro; Shin Dae Hong; Ko Hyojin; Ivanov Andrei A; Mamedova Liaman
Agonists and antagonists for P2 receptors.
Novartis Foundation symposium 2006;276():58-68; discussion 68-72, 107-12, 275-81.
2006: Matot Idit; Weiniger Carolyn F; Zeira Evelyne; Galun Eithan; Joshi Bhalchandra V; Jacobson Kenneth A
A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion.
Critical care (London, England) 2006;10(2):R65.
2005: Costanzi Stefano; Joshi Bhalchandra V; Maddileti Savitri; Mamedova Liaman; Gonzalez-Moa Maria J; Marquez Victor E; Harden T Kendall; Jacobson Kenneth A
Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.
Journal of medicinal chemistry 2005;48(26):8108-11.
2005: Jacobson Kenneth A; Gao Zhan-Guo; Tchilibon Susanna; Duong Heng T; Joshi Bhalchandra V; Sonin Dmitry; Liang Bruce T
Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.
Journal of medicinal chemistry 2005;48(26):8103-7.
2005: Mamedova Liaman; Capra Valérie; Accomazzo Maria Rosa; Gao Zhan-Guo; Ferrario Silvia; Fumagalli Marta; Abbracchio Maria P; Rovati G Enrico; Jacobson Kenneth A
CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors.
Biochemical pharmacology 2005;71(1-2):115-25.
2005: Berk Barkin; Akgün Hülya; Erol Kevser; Sirmagül Basar; Gao Zhan-Guo; Jacobson Kenneth A
New 8-substituted xanthiene derivatives as potent bronchodilators.
Farmaco (Società chimica italiana : 1989) 2005;60(11-12):974-80.
2005: Han Sung-Jun; Hamdan Fadi F; Kim Soo-Kyung; Jacobson Kenneth A; Bloodworth Lanh M; Li Bo; Wess Jürgen
Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor.
The Journal of biological chemistry 2005;280(41):34849-58.
2005: Niebauer Ronald T; Gao Zhan-Guo; Li Bo; Wess Jürgen; Jacobson Kenneth A
Signaling of the Human P2Y(1) Receptor Measured by a Yeast Growth Assay with Comparisons to Assays of Phospholipase C and Calcium Mobilization in 1321N1 Human Astrocytoma Cells.
Purinergic signalling 2005;1(3):241-7.
2005: Yang Hui; Avila Marcel Y; Peterson-Yantorno Kim; Coca-Prados Miguel; Stone Richard A; Jacobson Kenneth A; Civan Mortimer M
The cross-species A3 adenosine-receptor antagonist MRS 1292 inhibits adenosine-triggered human nonpigmented ciliary epithelial cell fluid release and reduces mouse intraocular pressure.
Current eye research 2005;30(9):747-54.
2005: Tchilibon Susanna; Zhang Jian; Yang Qingfeng; Eidelman Ofer; Kim Haksung; Caohuy Hung; Jacobson Kenneth A; Pollard Bette S; Pollard Harvey B
Amphiphilic pyridinium salts block TNF alpha/NF kappa B signaling and constitutive hypersecretion of interleukin-8 (IL-8) from cystic fibrosis lung epithelial cells.
Biochemical pharmacology 2005;70(3):381-93.
2005: Balogh Johanna; Wihlborg Anna-Karin; Isackson Henrik; Joshi Bhalchandra V; Jacobson Kenneth A; Arner Anders; Erlinge David
Phospholipase C and cAMP-dependent positive inotropic effects of ATP in mouse cardiomyocytes via P2Y11-like receptors.
Journal of molecular and cellular cardiology 2005;39(2):223-30.
2005: Perreira Melissa; Jiang Jian-Kang; Klutz Athena M; Gao Zhan-Guo; Shainberg Asher; Lu Changrui; Thomas Craig J; Jacobson Kenneth A
"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2005;48(15):4910-8.
2005: Kim Yong-Chul; Lee Jung-Sun; Sak Katrin; Marteau Frederic; Mamedova Liaman; Boeynaems Jean-Marie; Jacobson Kenneth A
Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor.
Biochemical pharmacology 2005;70(2):266-74.
2005: Han Sung-Jun; Hamdan Fadi F; Kim Soo-Kyung; Jacobson Kenneth A; Brichta Lars; Bloodworth Lanh M; Li Jian H; Wess Jürgen
Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor.
The Journal of biological chemistry 2005;280(26):24870-9.
2005: Gao Zhan-Guo; Kim Soo-Kyung; Ijzerman Adriaan P; Jacobson Kenneth A
Allosteric modulation of the adenosine family of receptors.
Mini reviews in medicinal chemistry 2005;5(6):545-53.
2005: Lee Jeong A; Moon Hyung Ryong; Kim Hea Ok; Kim Kyung Ran; Lee Kang Man; Kim Bum Tae; Hwang Ki Jun; Chun Moon Woo; Jacobson Kenneth A; Jeong Lak Shin
Synthesis of novel apio carbocyclic nucleoside analogues as selective a(3) adenosine receptor agonists.
The Journal of organic chemistry 2005;70(13):5006-13.
2005: Erdmann Andreas A; Gao Zhan-Guo; Jung Unsu; Foley Jason; Borenstein Todd; Jacobson Kenneth A; Fowler Daniel H
Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo.
Blood 2005;105(12):4707-14.
2005: Shneyvays Vladimir; Leshem Dorit; Zinman Tova; Mamedova Liaman K; Jacobson Kenneth A; Shainberg Asher
Role of adenosine A1 and A3 receptors in regulation of cardiomyocyte homeostasis after mitochondrial respiratory chain injury.
American journal of physiology. Heart and circulatory physiology 2005;288(6):H2792-801.
2005: Besada Pedro; Mamedova Liaman; Thomas Craig J; Costanzi Stefano; Jacobson Kenneth A
Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality.
Organic & biomolecular chemistry 2005;3(10):2016-25.
2005: Jacobson Kenneth A; Mamedova Liaman; Joshi Bhalchandra V; Besada Pedro; Costanzi Stefano
Molecular recognition at adenine nucleotide (P2) receptors in platelets.
Seminars in thrombosis and hemostasis 2005;31(2):205-16.
2005: Yitzhaki Smadar; Shneyvays Vladimir; Jacobson Kenneth A; Shainberg Asher
Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress.
Biochemical pharmacology 2005;69(8):1215-23.
2005: Tchilibon Susanna; Joshi Bhalchandra V; Kim Soo-Kyung; Duong Heng T; Gao Zhan-Guo; Jacobson Kenneth A
(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.
Journal of medicinal chemistry 2005;48(6):1745-58.
2005: Jacobson Kenneth A; Ohno Michihiro; Duong Heng T; Kim Soo-Kyung; Tchilibon Susanna; Cesnek Michal; Holý Antonín; Gao Zhan-Guo
A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.
Chemistry & biology 2005;12(2):237-47.
2005: Van Rompaey Philippe; Jacobson Kenneth A; Gross Ariel S; Gao Zhan-Guo; Van Calenbergh Serge
Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety.
Bioorganic & medicinal chemistry 2005;13(4):973-83.
2005: Hu Jianxin; McLarnon Stuart J; Mora Stefano; Jiang Jiankang; Thomas Craig; Jacobson Kenneth A; Spiegel Allen M
A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.
The Journal of biological chemistry 2005;280(6):5113-20.
2005: Li Bo; Nowak Nicola M; Kim Soo-Kyung; Jacobson Kenneth A; Bagheri Ali; Schmidt Clarice; Wess Jürgen
Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor.
The Journal of biological chemistry 2005;280(7):5664-75.
2005: Joshi Bhalchandra V; Moon Hyung Ryong; Fettinger James C; Marquez Victor E; Jacobson Kenneth A
A new synthetic route to (North)-methanocarba nucleosides designed as A3 adenosine receptor agonists.
The Journal of organic chemistry 2005;70(2):439-47.
2005: Moro Stefano; Spalluto Giampiero; Jacobson Kenneth A
Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine A3 receptor as an example.
Trends in pharmacological sciences 2005;26(1):44-51.
2005: Abbracchio Maria P; Burnstock Geoffrey; Boeynaems Jean-Marie; Barnard Eric A; Boyer José L; Kennedy Charles; Miras-Portugal Maria Teresa; King Brian F; Gachet Christian; Jacobson Kenneth A; Weisman Gary A
The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor.
Trends in pharmacological sciences 2005;26(1):8-9.
2005: Kim Ae Yil; Kim Hea Ok; Kim Myoung Jung; Chun Moon Woo; Lee Kang Man; Jacobson Kenneth A; Jeong Lak Shin
Synthesis of 3'-ureidoadenosines and their high binding affinity at the mutant A3 adenosine receptor.
Nucleic acids symposium series (2004) 2005;(49):105-6.
2005: Jeong Lak Shin; Lee Hyuk Woo; Jacobson Kenneth A; Lee Sang Kook; Chun Moon Woo
Development of potent and selective human A3 adenosine receptor agonists.
Nucleic acids symposium series (2004) 2005;(49):31-2.
2005: Duong Heng T; Gao Zhan-Guo; Jacobson Kenneth A
Nucleoside modification and concerted mutagenesis of the human A3 adenosine receptor to probe interactions between the 2-position of adenosine analogs and Gln167 in the second extracellular loop.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1507-17.
2005: Joshi Bhalchandra V; Jacobson Kenneth A
Purine derivatives as ligands for A3 adenosine receptors.
Current topics in medicinal chemistry 2005;5(13):1275-95.
2005: Chun Moon Woo; Lee Hyouk Woo; Kim Ae Yil; Kim Myong Jung; Kim Hea Ok; Gao Zhan-Guo; Jacobson Kenneth A; Jeong Lak Shin
Synthesis of 3'-ureidoadenosine analogues and their binding affinity to the A3 adenosine receptor.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):1119-21.
2005: Lee Hyouk Woo; Shin Dae Hong; Jeong Ji Young; Kim Hea Ok; Chun Moon Woo; Melman N; Gao Z G; Jacobson Kenneth A; Jeong Lak Shin
D-4'-thioadenosine derivatives as highly potent and selective agonists at the human A3 adenosine receptor.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):607-9.
2004: Olivecrona Goran K; Gotberg Matthias; Harnek Jan; Wang Lingwei; Jacobson Kenneth A; Erlinge David
Coronary artery reperfusion: The ADP receptor P2Y(1) mediates early reactive hyperemia in vivo in pigs.
Purinergic signalling 2004;1(1):59-65.
2004: Jacobson Kenneth A; Kim Soo-Kyung; Costanzi Stefano; Gao Zhan-Guo
Purine receptors: GPCR structure and agonist design.
Molecular interventions 2004;4(6):337-47.
2004: Chhatriwala Mariya; Ravi R Gnana; Patel Roshni I; Boyer Jose L; Jacobson Kenneth A; Harden T Kendall
Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1038-43.
2004: Hoffmann Carsten; Soltysiak Kelly; West Patrick L; Jacobson Kenneth A
Shift in purine/pyrimidine base recognition upon exchanging extracellular domains in P2Y 1/6 chimeric receptors.
Biochemical pharmacology 2004;68(10):2075-86.
2004: Cattaneo Marco; Lecchi Anna; Ohno Michihiro; Joshi Bhalchandra V; Besada Pedro; Tchilibon Susanna; Lombardi Rossana; Bischofberger Norbert; Harden T Kendall; Jacobson Kenneth A
Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor.
Biochemical pharmacology 2004;68(10):1995-2002.
2004: Gao Zhan-Guo; Mamedova Liaman K; Chen Peiran; Jacobson Kenneth A
2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors.
Biochemical pharmacology 2004;68(10):1985-93.
2004: Ohno Michihiro; Costanzi Stefano; Kim Hak Sung; Kempeneers Veerle; Vastmans Karen; Herdewijn Piet; Maddileti Savitri; Gao Zhan-Guo; Harden T Kendall; Jacobson Kenneth A
Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.
Bioorganic & medicinal chemistry 2004;12(21):5619-30.
2004: Costanzi Stefano; Mamedova Liaman; Gao Zhan-Guo; Jacobson Kenneth A
Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.
Journal of medicinal chemistry 2004;47(22):5393-404.
2004: Jeong Lak Shin; Kim Myong Jung; Kim Hea Ok; Gao Zhan-Guo; Kim Soo-Kyung; Jacobson Kenneth A; Chun Moon Woo
Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor.
Bioorganic & medicinal chemistry letters 2004;14(19):4851-4.
2004: Guerra L; Favia M; Fanelli T; Calamita G; Svetlo M; Bagorda A; Jacobson K A; Reshkin S J; Casavola V
Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells.
Pflügers Archiv : European journal of physiology 2004;449(1):66-75.
2004: Gao Zhan-Guo; Mamedova Liaman; Tchilibon Susanna; Gross Ariel S; Jacobson Kenneth A
2,2'-Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting nucleotide binding.
Biochemical pharmacology 2004;68(2):231-7.
2004: Ohno Michihiro; Gao Zhan-Guo; Van Rompaey Philippe; Tchilibon Susanna; Kim Soo-Kyung; Harris Brian A; Gross Ariel S; Duong Heng T; Van Calenbergh Serge; Jacobson Kenneth A
Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position.
Bioorganic & medicinal chemistry 2004;12(11):2995-3007.
2004: Srivastava Meera; Eidelman Ofer; Zhang Jian; Paweletz Cloud; Caohuy Hung; Yang QingFeng; Jacobson Kenneth A; Heldman Eliahu; Huang Wei; Jozwik Catherine; Pollard Bette S; Pollard Harvey B
Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7693-8.
2004: Mamedova Liaman K; Joshi Bhalchandra V; Gao Zhan-Guo; von Kügelgen Ivar; Jacobson Kenneth A
Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors.
Biochemical pharmacology 2004;67(9):1763-70.
2004: Gao Zhan-Guo; Gross Ariel S; Jacobson Kenneth A
Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors.
Life sciences 2004;74(25):3173-80.
2004: Tchilibon Susanna; Kim Soo-Kyung; Gao Zhan-Guo; Harris Brian A; Blaustein Joshua B; Gross Ariel S; Duong Heng T; Melman Neli; Jacobson Kenneth A
Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands.
Bioorganic & medicinal chemistry 2004;12(9):2021-34.
2004: Gao Zhan-Guo; Jeong Lak Shin; Moon Hyung Ryong; Kim Hea Ok; Choi Won Jun; Shin Dae Hong; Elhalem Eleonora; Comin Maria J; Melman Neli; Mamedova Liaman; Gross Ariel S; Rodriguez Juan B; Jacobson Kenneth A
Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety.
Biochemical pharmacology 2004;67(5):893-901.
2004: Jung Kwan-Young; Kim Soo-Kyung; Gao Zhan-Guo; Gross Ariel S; Melman Neli; Jacobson Kenneth A; Kim Yong-Chul
Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.
Bioorganic & medicinal chemistry 2004;12(3):613-23.
2004: Mozzicato Susan; Joshi Bhalchandra V; Jacobson Kenneth A; Liang Bruce T
Role of direct RhoA-phospholipase D1 interaction in mediating adenosine-induced protection from cardiac ischemia.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):406-8.
2004: Gao Zhan-Guo; Jacobson Kenneth A
Partial agonists for A(3) adenosine receptors.
Current topics in medicinal chemistry 2004;4(8):855-62.
2004: Jacobson Kenneth A; Costanzi Stefano; Ohno Michihiro; Joshi Bhalchandra V; Besada Pedro; Xu Bin; Tchilibon Susanna
Molecular recognition at purine and pyrimidine nucleotide (P2) receptors.
Current topics in medicinal chemistry 2004;4(8):805-19.
2003: Moro Stefano; Deflorian Francesca; Spalluto Giampiero; Pastorin Giorgia; Cacciari Barbara; Kim Soo-Kyung; Jacobson Kenneth A
Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling.
Chemical communications (Cambridge, England) 2003;(24):2949-56.
2003: Kim Hak Sung; Ohno Michihiro; Xu Bin; Kim Hea Ok; Choi Yongseok; Ji Xiao D; Maddileti Savitri; Marquez Victor E; Harden T Kendall; Jacobson Kenneth A
2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.
Journal of medicinal chemistry 2003;46(23):4974-87.
2003: Kim Soo-Kyung; Gao Zhan-Guo; Van Rompaey Philippe; Gross Ariel S; Chen Aishe; Van Calenbergh Serge; Jacobson Kenneth A
Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists.
Journal of medicinal chemistry 2003;46(23):4847-59.
2003: Goldenberg Ilan; Shainberg Asher; Jacobson Kenneth A; Shneyvays Vladimir; Grossman Ehud
Adenosine protects against angiotensin II-induced apoptosis in rat cardiocyte cultures.
Molecular and cellular biochemistry 2003;252(1-2):133-9.
2003: Eltzschig Holger K; Ibla Juan C; Furuta Glenn T; Leonard Martin O; Jacobson Kenneth A; Enjyoji Keiichi; Robson Simon C; Colgan Sean P
Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors.
The Journal of experimental medicine 2003;198(5):783-96.
2003: Gorman Mark W; Ogimoto Kayoko; Savage Margaret V; Jacobson Kenneth A; Feigl Eric O
Nucleotide coronary vasodilation in guinea pig hearts.
American journal of physiology. Heart and circulatory physiology 2003;285(3):H1040-7.
2003: Jeong Lak Shin; Jin Dong Zhe; Kim Hea Ok; Shin Dae Hong; Moon Hyung Ryong; Gunaga Prashantha; Chun Moon Woo; Kim Yong-Chul; Melman Neli; Gao Zhan-Guo; Jacobson Kenneth A
N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.
Journal of medicinal chemistry 2003;46(18):3775-7.
2003: Choi Yongseok; George Clifford; Comin Maria J; Barchi Joseph J; Kim Hak Sung; Jacobson Kenneth A; Balzarini Jan; Mitsuya Hiroaki; Boyer Paul L; Hughes Stephen H; Marquez Victor E
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.
Journal of medicinal chemistry 2003;46(15):3292-9.
2003: Fedorova Irina M; Jacobson Marlene A; Basile Anthony; Jacobson Kenneth A
Behavioral characterization of mice lacking the A3 adenosine receptor: sensitivity to hypoxic neurodegeneration.
Cellular and molecular neurobiology 2003;23(3):431-47.
2003: Kim Seong G; Gao Zhan-Guo; Soltysiak Kelly A; Chang Tong-Shin; Brodie Chaya; Jacobson Kenneth A
P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis.
Cellular and molecular neurobiology 2003;23(3):401-18.
2003: Kim Hea Ok; Park Jae Gyu; Moon Hyung Ryong; Gunaga Prashantha; Lim Moo Hong; Chun Moon Woo; Jacobson Kenneth A; Kim Hee-Doo; Jeong Lak Shin
Design and synthesis of A3 adenosine receptor ligands, 2'-fluoro analogues of Cl-IB-MECA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):927-30.
2003: Kim Hea Ok; Lim Moo Hong; Park Jae Gyu; Moon Hyung Ryong; Jacobson Kenneth A; Kim Hee-Doo; Chun Moon Woo; Jeong Lak Shin
Design and synthesis of A3 adenosine receptor ligands, 3'-fluoro analogues of Cl-IB-MECA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):923-5.
2003: Gao Zhan-Guo; Blaustein Joshua B; Gross Ariel S; Melman Neli; Jacobson Kenneth A
N6-Substituted adenosine derivatives: selectivity, efficacy, and species differences at A3 adenosine receptors.
Biochemical pharmacology 2003;65(10):1675-84.
2003: Kim Hak Sung; Jacobson Kenneth A
Synthesis of a novel conformationally locked carbocyclic nucleoside ring system.
Organic letters 2003;5(10):1665-8.
2003: Gao Zhan-Guo; Kim Soo-Kyung; Gross Ariel S; Chen Aishe; Blaustein Joshua B; Jacobson Kenneth A
Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor.
Molecular pharmacology 2003;63(5):1021-31.
2003: Wihlborg Anna-Karin; Malmsjö Malin; Eyjolfsson Atli; Gustafsson Ronny; Jacobson Kenneth; Erlinge David
Extracellular nucleotides induce vasodilatation in human arteries via prostaglandins, nitric oxide and endothelium-derived hyperpolarising factor.
British journal of pharmacology 2003;138(8):1451-8.
2003: Kim Seong G; Soltysiak Kelly A; Gao Zhan-Guo; Chang Tong-Shin; Chung Eunju; Jacobson Kenneth A
Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.
Biochemical pharmacology 2003;65(6):923-31.
2003: Lim Moo Hong; Kim Hea Ok; Moon Hyung Ryong; Lee Seung Jin; Chun Moon Woo; Gao Zhan-Guo; Melman Neli; Jacobson Kenneth A; Kim Joong Hyup; Jeong Lak Shin
Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands.
Bioorganic & medicinal chemistry letters 2003;13(5):817-20.
2003: Gao Zhan-Guo; Melman Neli; Erdmann Andreas; Kim Seong Gon; Müller Christa E; IJzerman Adriaan P; Jacobson Kenneth A
Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors.
Biochemical pharmacology 2003;65(4):525-34.
2003: Abbracchio Maria P; Boeynaems Jean-Marie; Barnard Eric A; Boyer José L; Kennedy Charles; Miras-Portugal Maria Teresa; King Brian F; Gachet Christian; Jacobson Kenneth A; Weisman Gary A; Burnstock Geoffrey
Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.
Trends in pharmacological sciences 2003;24(2):52-5.
2003: Harper Jacquie L; Camerini-Otero Carol S; Li An Hu; Kim Soon Ai; Jacobson Kenneth A; Daly John W
Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells.
Biochemical pharmacology 2003;65(3):329-38.
2003: Ozola Vita; Thorand Mark; Diekmann Martina; Qurishi Ramatullah; Schumacher Britta; Jacobson Kenneth A; Müller Christa E
2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors.
Bioorganic & medicinal chemistry 2003;11(3):347-56.
2003: Webb Thomas R; Lvovskiy Dmitriy; Kim Soon Ai; Ji Xiao duo; Melman Neli; Linden Joel; Jacobson Kenneth A
Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors.
Bioorganic & medicinal chemistry 2003;11(1):77-85.
2003: Chun Moon Woo; Lim Moo Hong; Moon Hyung Ryong; Kim Hea Ok; Jacobson Kenneth A; Jeong Lak Shin
Synthesis of 3'-fluoro analogue of Cl-IB-MECA as adenosine A3 receptor ligand.
Nucleic acids research. Supplement (2001) 2003;(3):19-20.
2003: Jacobson Kenneth A
Molecular recognition in P2 nucleotide receptors.
Nucleic acids research. Supplement (2001) 2003;(3):3-4.
2002: Xu Bin; Stephens Andrew; Kirschenheuter Gary; Greslin Arthur F; Cheng Xiaoquin; Sennelo Joe; Cattaneo Marco; Zighetti Maddalena L; Chen Aishe; Kim Soon-Ai; Kim Hak Sung; Bischofberger Norbert; Cook Gary; Jacobson Kenneth A
Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: phosphate substitution leads to multiple pathways of inhibition of platelet aggregation.
Journal of medicinal chemistry 2002;45(26):5694-709.
2002: Trincavelli M L; Tuscano D; Marroni M; Falleni A; Gremigni V; Ceruti S; Abbracchio M P; Jacobson K A; Cattabeni F; Martini C
A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation.
Molecular pharmacology 2002;62(6):1373-84.
2002: Waldo Gary L; Corbitt James; Boyer José L; Ravi Gnana; Kim Hak Sung; Ji Xiao-Duo; Lacy James; Jacobson Kenneth A; Harden T Kendall
Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist.
Molecular pharmacology 2002;62(5):1249-57.
2002: Hu Jianxin; Reyes-Cruz Guadalupe; Chen Wangzhong; Jacobson Kenneth A; Spiegel Allen M
Identification of acidic residues in the extracellular loops of the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ and a positive allosteric modulator.
The Journal of biological chemistry 2002;277(48):46622-31.
2002: Gao Zhan-Guo; Kim Soo-Kyung; Biadatti Thibaud; Chen Wangzhong; Lee Kyeong; Barak Dov; Kim Seong Gon; Johnson Carl R; Jacobson Kenneth A
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Journal of medicinal chemistry 2002;45(20):4471-84.
2002: Chen Wangzhong; Ravi R Gnana; Kertesy Sylvia B; Dubyak George R; Jacobson Kenneth A
Functionalized congeners of tyrosine-based P2X(7) receptor antagonists: probing multiple sites for linking and dimerization.
Bioconjugate chemistry 2002;13(5):1100-11.
2002: Jacobson Kenneth A; Jarvis Michael F; Williams Michael
Purine and pyrimidine (P2) receptors as drug targets.
Journal of medicinal chemistry 2002;45(19):4057-93.
2002: Bagorda A; Guerra L; Di Sole F; Helmle-Kolb C; Favia M; Jacobson K A; Casavola V; Reshkin S J
Extracellular adenine nucleotides regulate Na+/H+ exchanger NHE3 activity in A6-NHE3 transfectants by a cAMP/PKA-dependent mechanism.
The Journal of membrane biology 2002;188(3):249-59.
2002: Maconi Anna; Pastorin Giorgia; Da Ros Tatiana; Spalluto Giampiero; Gao Zhan-Guo; Jacobson Kenneth A; Baraldi Pier Giovanni; Cacciari Barbara; Varani Katia; Moro Stefano; Borea Pier Andrea
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.
Journal of medicinal chemistry 2002;45(17):3579-82.
2002: Müller Christa E; Thorand Mark; Qurishi Ramatullah; Diekmann Martina; Jacobson Kenneth A; Padgett William L; Daly John W
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(16):3440-50.
2002: Gao Zhan-Guo; Kim Seong Gon; Soltysiak Kelly A; Melman Neli; IJzerman Adriaan P; Jacobson Kenneth A
Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.
Molecular pharmacology 2002;62(1):81-9.
2002: Talukder M A Hassan; Morrison R Ray; Jacobson Marlene A; Jacobson Kenneth A; Ledent Catherine; Mustafa S Jamal
Targeted deletion of adenosine A(3) receptors augments adenosine-induced coronary flow in isolated mouse heart.
American journal of physiology. Heart and circulatory physiology 2002;282(6):H2183-9.
2002: Gao Zhan-guo; Jacobson Kenneth A
2-Chloro-N(6)-cyclopentyladenosine, adenosine A(1) receptor agonist, antagonizes the adenosine A(3) receptor.
European journal of pharmacology 2002;443(1-3):39-42.
2002: Kim Soon-Ai; Marshall Melissa A; Melman Neli; Kim Hak Sung; Müller Christa E; Linden Joel; Jacobson Kenneth A
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
Journal of medicinal chemistry 2002;45(11):2131-8.
2002: Ravi R Gnana; Kim Hak Sung; Servos Jörg; Zimmermann Herbert; Lee Kyeong; Maddileti Savitri; Boyer José L; Harden T Kendall; Jacobson Kenneth A
Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.
Journal of medicinal chemistry 2002;45(10):2090-100.
2002: Gao Zhan-Guo; Chen Aishe; Barak Dov; Kim Soo-Kyung; Müller Christa E; Jacobson Kenneth A
Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor.
The Journal of biological chemistry 2002;277(21):19056-63.
2002: Boyer José L; Adams Mary; Ravi R Gnana; Jacobson Kenneth A; Harden T Kendall
2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist.
British journal of pharmacology 2002;135(8):2004-10.
2002: Kim Seong Gon; Ravi Gnana; Hoffmann Carsten; Jung Yun Jin; Kim Min; Chen Aishe; Jacobson Kenneth A
p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA.
Biochemical pharmacology 2002;63(5):871-80.
2002: Brown Sean G; Townsend-Nicholson Andrea; Jacobson Kenneth A; Burnstock Geoffrey; King Brian F
Heteromultimeric P2X(1/2) receptors show a novel sensitivity to extracellular pH.
The Journal of pharmacology and experimental therapeutics 2002;300(2):673-80.
2002: Kim Hak Sung; Ravi R Gnana; Marquez Victor E; Maddileti Savitri; Wihlborg Anna-Karin; Erlinge David; Malmsjö Malin; Boyer José L; Harden T Kendall; Jacobson Kenneth A
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
Journal of medicinal chemistry 2002;45(1):208-18.
2002: Moro Stefano; Jacobson Kenneth A
Molecular modeling as a tool to investigate molecular recognition in P2Y receptors.
Current pharmaceutical design 2002;8(26):2401-13.
2002: Jacobson Kenneth A; Moro Stefano; Manthey John A; West Patrick L; Ji Xiao-Duo
Interactions of flavones and other phytochemicals with adenosine receptors.
Advances in experimental medicine and biology 2002;505():163-71.
2001: Appel E; Kazimirsky G; Ashkenazi E; Kim S G; Jacobson K A; Brodie C
Roles of BCL-2 and caspase 3 in the adenosine A3 receptor-induced apoptosis.
Journal of molecular neuroscience : MN 2001;17(3):285-92.
2001: Fredholm B B; IJzerman A P; Jacobson K A; Klotz K N; Linden J
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.
Pharmacological reviews 2001;53(4):527-52.
2001: Jacobson K A; Gao Z G; Chen A; Barak D; Kim S A; Lee K; Link A; Rompaey P V; van Calenbergh S; Liang B T
Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.
Journal of medicinal chemistry 2001;44(24):4125-36.
2001: Gao Z G; Van Muijlwijk-Koezen J E; Chen A; Müller C E; Ijzerman A P; Jacobson K A
Allosteric modulation of A(3) adenosine receptors by a series of 3-(2-pyridinyl)isoquinoline derivatives.
Molecular pharmacology 2001;60(5):1057-63.
2001: Goldenberg I; Grossman E; Jacobson K A; Shneyvays V; Shainberg A
Angiotensin II-induced apoptosis in rat cardiomyocyte culture: a possible role of AT1 and AT2 receptors.
Journal of hypertension 2001;19(9):1681-9.
2001: Kim H S; Barak D; Harden T K; Boyer J L; Jacobson K A
Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking.
Journal of medicinal chemistry 2001;44(19):3092-108.
2001: Ravi G; Lee K; Ji X; Kim H S; Soltysiak K A; Marquez V E; Jacobson K A
Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings.
Bioorganic & medicinal chemistry letters 2001;11(17):2295-300.
2001: Eidelman O; Srivastava M; Zhang J; Leighton X; Murtie J; Jozwik C; Jacobson K; Weinstein D L; Metcalf E L; Pollard H B
Control of the proinflammatory state in cystic fibrosis lung epithelial cells by genes from the TNF-alphaR/NFkappaB pathway.
Molecular medicine (Cambridge, Mass.) 2001;7(8):523-34.
2001: Baraldi P G; Cacciari B; Moro S; Romagnoli R; Ji Xd; Jacobson K A; Gessi S; Borea P A; Spalluto G
Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.
Journal of medicinal chemistry 2001;44(17):2735-42.
2001: Abbracchio M P; Camurri A; Ceruti S; Cattabeni F; Falzano L; Giammarioli A M; Jacobson K A; Trincavelli L; Martini C; Malorni W; Fiorentini C
The A3 adenosine receptor induces cytoskeleton rearrangement in human astrocytoma cells via a specific action on Rho proteins.
Annals of the New York Academy of Sciences 2001;939():63-73.
2001: Shneyvays V; Mamedova L; Zinman T; Jacobson K; Shainberg A
Activation of A(3)adenosine receptor protects against doxorubicin-induced cardiotoxicity.
Journal of molecular and cellular cardiology 2001;33(6):1249-61.
2001: Chen A; Gao Z G; Barak D; Liang B T; Jacobson K A
Constitutive activation of A(3) adenosine receptors by site-directed mutagenesis.
Biochemical and biophysical research communications 2001;284(3):596-601.
2001: Lee K; Ravi G; Ji X D; Marquez V E; Jacobson K A
Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.
Bioorganic & medicinal chemistry letters 2001;11(10):1333-7.
2001: Pollard H B; Eidelman O; Jacobson K A; Srivastava M
Pharmacogenomics of cystic fibrosis.
Molecular interventions 2001;1(1):54-63.
2001: Jacobson K A; Ravi R G; Nandanan E; Kim H S; Moro S; Kim Y C; Lee K; Barak D; Marquez V E; Ji X D
Ribose modified nucleosides and nucleotides as ligands for purine receptors.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):333-41.
2001: Ji X; Kim Y C; Ahern D G; Linden J; Jacobson K A
[3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors.
Biochemical pharmacology 2001;61(6):657-63.
2001: Kim Y C; Brown S G; Harden T K; Boyer J L; Dubyak G; King B F; Burnstock G; Jacobson K A
Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors.
Journal of medicinal chemistry 2001;44(3):340-9.
2001: Lee K; Cass C; Jacobson K A
Synthesis using ring closure metathesis and effect on nucleoside transport of a (N)-methanocarba S-(4-nitrobenzyl)thioinosine derivative.
Organic letters 2001;3(4):597-9.
2001: Jacobson K A; Moro S; Hoffmann C; Kim Y C; Kim H S; Ravi R G; Harden T K; Boyer J L
Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors.
Farmaco (Società chimica italiana : 1989) 2001;56(1-2):71-5.
2001: Safran N; Shneyvays V; Balas N; Jacobson K A; Nawrath H; Shainberg A
Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes.
Molecular and cellular biochemistry 2001;217(1-2):143-52.
2000: Hauache O M; Hu J; Ray K; Xie R; Jacobson K A; Spiegel A M
Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors.
Endocrinology 2000;141(11):4156-63.
2000: Reshkin S J; Guerra L; Bagorda A; Debellis L; Cardone R; Li A H; Jacobson K A; Casavola V
Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells.
The Journal of membrane biology 2000;178(2):103-13.
2000: Gao Z G; Jiang Q; Jacobson K A; Ijzerman A P
Site-directed mutagenesis studies of human A(2A) adenosine receptors: involvement of glu(13) and his(278) in ligand binding and sodium modulation.
Biochemical pharmacology 2000;60(5):661-8.
2000: Jacobson K A; Xie R; Young L; Chang L; Liang B T
A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists.
The Journal of biological chemistry 2000;275(39):30272-9.
2000: Parsons M; Young L; Lee J E; Jacobson K A; Liang B T
Distinct cardioprotective effects of adenosine mediated by differential coupling of receptor subtypes to phospholipases C and D.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(10):1423-31.
2000: Jacobson K A; Kim Y C; King B F
In search of selective P2 receptor ligands: interaction of dihydropyridine derivatives at recombinant rat P2X(2) receptors.
Journal of the autonomic nervous system 2000;81(1-3):152-7.
2000: Jacobson K A; Ji X; Li A H; Melman N; Siddiqui M A; Shin K J; Marquez V E; Ravi R G
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.
Journal of medicinal chemistry 2000;43(11):2196-203.
2000: Shneyvays V; Jacobson K A; Li A H; Nawrath H; Zinman T; Isaac A; Shainberg A
Induction of apoptosis in rat cardiocytes by A3 adenosine receptor activation and its suppression by isoproterenol.
Experimental cell research 2000;257(1):111-26.
2000: Jiang X; Lim L Y; Daly J W; Li A H; Jacobson K A; Roberge M
Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs.
International journal of oncology 2000;16(5):971-8.
2000: Kim Y C; Ji X; Melman N; Linden J; Jacobson K A
Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.
Journal of medicinal chemistry 2000;43(6):1165-72.
2000: Brambilla R; Cattabeni F; Ceruti S; Barbieri D; Franceschi C; Kim Y C; Jacobson K A; Klotz K N; Lohse M J; Abbracchio M P
Activation of the A3 adenosine receptor affects cell cycle progression and cell growth.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(3):225-34.
2000: Nandanan E; Jang S Y; Moro S; Kim H O; Siddiqui M A; Russ P; Marquez V E; Busson R; Herdewijn P; Harden T K; Boyer J L; Jacobson K A
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.
Journal of medicinal chemistry 2000;43(5):829-42.
2000: Kim Y C; Gallo-Rodriguez C; Jang S Y; Nandanan E; Adams M; Harden T K; Boyer J L; Jacobson K A
Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists.
Journal of medicinal chemistry 2000;43(4):746-55.
2000: Webb T R; Melman N; Lvovskiy D; Ji X D; Jacobson K A
The utilization of a unified pharmacophore query in the discovery of new antagonists of the adenosine receptor family.
Bioorganic & medicinal chemistry letters 2000;10(1):31-4.
1999: Liang B T; Jacobson K A
Adenosine and ischemic preconditioning.
Current pharmaceutical design 1999;5(12):1029-41.
1999: Ji X D; Jacobson K A
Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.
Drug design and discovery 1999;16(3):217-26.
1999: Xie R; Li A H; Ji X D; Melman N; Olah M E; Stiles G L; Jacobson K A
Selective A(3) adenosine receptor antagonists: water-soluble 3, 5-diacyl-1,2,4-trialkylpyridinium salts and their oxidative generation from dihydropyridine precursors.
Journal of medicinal chemistry 1999;42(20):4232-8.
1999: Jiang J; Li A H; Jang S Y; Chang L; Melman N; Moro S; Ji X; Lobkovsky E B; Clardy J C; Jacobson K A
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 1999;42(16):3055-65.
1999: Fischer B; Yefidoff R; Major D T; Rutman-Halili I; Shneyvays V; Zinman T; Jacobson K A; Shainberg A
Characterization of "mini-nucleotides" as P2X receptor agonists in rat cardiomyocyte cultures. An integrated synthetic, biochemical, and theoretical study.
Journal of medicinal chemistry 1999;42(14):2685-96.
1999: Li A H; Chang L; Ji X d; Melman N; Jacobson K A
Functionalized congeners of 1,4-dihydropyridines as antagonist molecular probes for A3 adenosine receptors.
Bioconjugate chemistry 1999;10(4):667-77.
1999: Jacobson K A; Hoffmann C; Cattabeni F; Abbracchio M P
Adenosine-induced cell death: evidence for receptor-mediated signalling.
Apoptosis : an international journal on programmed cell death 1999;4(3):197-211.
1999: Stambaugh K; Elliott G T; Jacobson K A; Liang B T
Additive effects of late preconditioning produced by monophosphoryl lipid A and the early preconditioning mediated by adenosine receptors and KATP channel.
Circulation 1999;99(25):3300-7.
1999: Hoffmann C; Moro S; Nicholas R A; Harden T K; Jacobson K A
The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes.
The Journal of biological chemistry 1999;274(21):14639-47.
1999: Nandanan E; Camaioni E; Jang S Y; Kim Y C; Cristalli G; Herdewijn P; Secrist J A; Tiwari K N; Mohanram A; Harden T K; Boyer J L; Jacobson K A
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.
Journal of medicinal chemistry 1999;42(9):1625-38.
1999: Von Lubitz D K; Lin R C; Bischofberger N; Beenhakker M; Boyd M; Lipartowska R; Jacobson K A
Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist.
European journal of pharmacology 1999;369(3):313-7.
1999: Moro S; Hoffmann C; Jacobson K A
Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.
Biochemistry 1999;38(12):3498-507.
1999: Von Lubitz D K; Lin R C; Boyd M; Bischofberger N; Jacobson K A
Chronic administration of adenosine A3 receptor agonist and cerebral ischemia: neuronal and glial effects.
European journal of pharmacology 1999;367(2-3):157-63.
1999: Li A H; Moro S; Forsyth N; Melman N; Ji X D; Jacobson K A
Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 1999;42(4):706-21.
1999: el-Ani D; Jacobson K A; Zimlichman R; Katz A; Shainberg A
Uptake of glucose analogs reflects the rate of contraction of cultured myocytes.
Journal of basic and clinical physiology and pharmacology 1999;10(4):287-303.
1999: Dunwiddie T V; Jacobson K A; Diao L
An adenosine A3 receptor-selective agonist does not modulate calcium-activated potassium currents in hippocampal CA1 pyramidal neurons.
Progress in brain research 1999;120():275-85.
1999: Jacobson K A; Hoffmann C; Kim Y C; Camaioni E; Nandanan E; Jang S Y; Guo D P; Ji X D; von Kügelgen I; Moro S; Ziganshin A U; Rychkov A; King B F; Brown S G; Wildman S S; Burnstock G; Boyer J L; Mohanram A; Harden T K
Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis.
Progress in brain research 1999;120():119-32.
1998: Dougherty C; Barucha J; Schofield P R; Jacobson K A; Liang B T
Cardiac myocytes rendered ischemia resistant by expressing the human adenosine A1 or A3 receptor.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(15):1785-92.
1998: Moro S; Li A H; Jacobson K A
Molecular modeling studies of human A3 adenosine antagonists: structural homology and receptor docking.
Journal of chemical information and computer sciences 1998;38(6):1239-48.
1998: Shneyvays V; Nawrath H; Jacobson K A; Shainberg A
Induction of apoptosis in cardiac myocytes by an A3 adenosine receptor agonist.
Experimental cell research 1998;243(2):383-97.
1998: Li A H; Moro S; Melman N; Ji X D; Jacobson K A
Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 1998;41(17):3186-201.
1998: Baraldi P G; Cacciari B; Pineda de Las Infantas M J; Romagnoli R; Spalluto G; Volpini R; Costanzi S; Vittori S; Cristalli G; Melman N; Park K S; Ji X D; Jacobson K A
Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.
Journal of medicinal chemistry 1998;41(17):3174-85.
1998: Kim Y C; de Zwart M; Chang L; Moro S; von Frijtag Drabbe Künzel J K; Melman N; IJzerman A P; Jacobson K A
Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.
Journal of medicinal chemistry 1998;41(15):2835-45.
1998: de Zwart M; Link R; von Frijtag Drabbe Künzel J K; Cristalli G; Jacobson K A; Townsend-Nicholson A; IJzerman A P
A functional screening of adenosine analogues at the adenosine A2B receptor: a search for potent agonists.
Nucleosides & nucleotides 1998;17(6):969-85.
1998: Brodie C; Blumberg P M; Jacobson K A
Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells.
FEBS letters 1998;429(2):139-42.
1998: Jacobson K A; Kim Y C; Wildman S S; Mohanram A; Harden T K; Boyer J L; King B F; Burnstock G
A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors.
Journal of medicinal chemistry 1998;41(13):2201-6.
1998: Liang B T; Jacobson K A
A physiological role of the adenosine A3 receptor: sustained cardioprotection.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6995-9.
1998: Barbieri D; Abbracchio M P; Salvioli S; Monti D; Cossarizza A; Ceruti S; Brambilla R; Cattabeni F; Jacobson K A; Franceschi C
Apoptosis by 2-chloro-2'-deoxy-adenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells.
Neurochemistry international 1998;32(5-6):493-504.
1998: Jacobson K A
Adenosine A3 receptors: novel ligands and paradoxical effects.
Trends in pharmacological sciences 1998;19(5):184-91.
1998: Boyer J L; Mohanram A; Camaioni E; Jacobson K A; Harden T K
Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.
British journal of pharmacology 1998;124(1):1-3.
1998: Bridson P K; Lin X; Melman N; Ji X D; Jacobson K A
Synthesis and adenosine receptor affinity of 7-beta-D-ribofuranosylxanthine.
Nucleosides & nucleotides 1998;17(4):759-68.
1998: Moro S; Guo D; Camaioni E; Boyer J L; Harden T K; Jacobson K A
Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.
Journal of medicinal chemistry 1998;41(9):1456-66.
1998: Arispe N; Ma J; Jacobson K A; Pollard H B
Direct activation of cystic fibrosis transmembrane conductance regulator channels by 8-cyclopentyl-1,3-dipropylxanthine (CPX) and 1,3-diallyl-8-cyclohexylxanthine (DAX).
The Journal of biological chemistry 1998;273(10):5727-34.
1998: Camaioni E; Boyer J L; Mohanram A; Harden T K; Jacobson K A
Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors.
Journal of medicinal chemistry 1998;41(2):183-90.
1998: Moro S; van Rhee A M; Sanders L H; Jacobson K A
Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model.
Journal of medicinal chemistry 1998;41(1):46-52.
1997: Abbracchio M P; Rainaldi G; Giammarioli A M; Ceruti S; Brambilla R; Cattabeni F; Barbieri D; Franceschi C; Jacobson K A; Malorni W
The A3 adenosine receptor mediates cell spreading, reorganization of actin cytoskeleton, and distribution of Bcl-XL: studies in human astroglioma cells.
Biochemical and biophysical research communications 1997;241(2):297-304.
1997: Bischofberger N; Jacobson K A; von Lubitz D K
Adenosine A1 receptor agonists as clinically viable agents for treatment of ischemic brain disorders.
Annals of the New York Academy of Sciences 1997;825():23-9.
1997: Abbracchio M P; Ceruti S; Brambilla R; Franceschi C; Malorni W; Jacobson K A; von Lubitz D K; Cattabeni F
Modulation of apoptosis by adenosine in the central nervous system: a possible role for the A3 receptor. Pathophysiological significance and therapeutic implications for neurodegenerative disorders.
Annals of the New York Academy of Sciences 1997;825():11-22.
1997: Jacobson K A; Park K S; Jiang J L; Kim Y C; Olah M E; Stiles G L; Ji X D
Pharmacological characterization of novel A3 adenosine receptor-selective antagonists.
Neuropharmacology 1997;36(9):1157-65.
1997: El-Ani D; Jacobson K A; Shainberg A
Regulation of A1 adenosine receptors by amiodarone and electrical stimulation in rat myocardial cells in vitro.
Biochemical pharmacology 1997;54(5):583-7.
1997: Jiang Q; Guo D; Lee B X; Van Rhee A M; Kim Y C; Nicholas R A; Schachter J B; Harden T K; Jacobson K A
A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor.
Molecular pharmacology 1997;52(3):499-507.
1997: Zhang J; Belardinelli L; Jacobson K A; Otero D H; Baker S P
Persistent activation by and receptor reserve for an irreversible A1-adenosine receptor agonist in DDT1 MF-2 cells and in guinea pig heart.
Molecular pharmacology 1997;52(3):491-8.
1997: Jiang J; van Rhee A M; Chang L; Patchornik A; Ji X D; Evans P; Melman N; Jacobson K A
Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 1997;40(16):2596-608.
1997: Jiang Q; Lee B X; Glashofer M; van Rhee A M; Jacobson K A
Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors.
Journal of medicinal chemistry 1997;40(16):2588-95.
1997: Stambaugh K; Jacobson K A; Jiang J L; Liang B T
A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia.
The American journal of physiology 1997;273(1 Pt 2):H501-5.
1997: Cohen B E; Lee G; Jacobson K A; Kim Y C; Huang Z; Sorscher E J; Pollard H B
8-cyclopentyl-1,3-dipropylxanthine and other xanthines differentially bind to the wild-type and delta F508 first nucleotide binding fold (NBF-1) domains of the cystic fibrosis transmembrane conductance regulator.
Biochemistry 1997;36(21):6455-61.
1997: Fredholm B B; Abbracchio M P; Burnstock G; Dubyak G R; Harden T K; Jacobson K A; Schwabe U; Williams M
Towards a revised nomenclature for P1 and P2 receptors.
Trends in pharmacological sciences 1997;18(3):79-82.
1997: Yao Y; Sei Y; Abbracchio M P; Jiang J L; Kim Y C; Jacobson K A
Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists.
Biochemical and biophysical research communications 1997;232(2):317-22.
1997: Casavola V; Guerra L; Reshkin S J; Jacobson K A; Murer H
Polarization of adenosine effects on intracellular pH in A6 renal epithelial cells.
Molecular pharmacology 1997;51(3):516-23.
1997: Dunwiddie T V; Diao L; Kim H O; Jiang J L; Jacobson K A
Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(2):607-14.
1997: Dai R; Jacobson K A; Robinson R C; Friedman F K
Differential effects of flavonoids on testosterone-metabolizing cytochrome P450s.
Life sciences 1997;61(7):PL75-80.
1996: Von Lubitz D K; Lin R C; Paul I A; Beenhakker M; Boyd M; Bischofberger N; Jacobson K A
Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils.
European journal of pharmacology 1996;316(2-3):171-9.
1996: Jiang J L; van Rhee A M; Melman N; Ji X D; Jacobson K A
6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 1996;39(23):4667-75.
1996: Kohno Y; Ji X; Mawhorter S D; Koshiba M; Jacobson K A
Activation of A3 adenosine receptors on human eosinophils elevates intracellular calcium.
Blood 1996;88(9):3569-74.
1996: Strickler J; Jacobson K A; Liang B T
Direct preconditioning of cultured chick ventricular myocytes. Novel functions of cardiac adenosine A2a and A3 receptors.
The Journal of clinical investigation 1996;98(8):1773-9.
1996: Kim Y C; Ji X D; Jacobson K A
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.
Journal of medicinal chemistry 1996;39(21):4142-8.
1996: Jiang Q; Van Rhee A M; Kim J; Yehle S; Wess J; Jacobson K A
Hydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognition.
Molecular pharmacology 1996;50(3):512-21.
1996: IJzerman A P; Von Frijtag Drabbe Künzel J K; Kim J; Jiang Q; Jacobson K A
Site-directed mutagenesis of the human adenosine A2A receptor. Critical involvement of Glu13 in agonist recognition.
European journal of pharmacology 1996;310(2-3):269-72.
1996: Boyer J L; Siddiqi S; Fischer B; Romero-Avila T; Jacobson K A; Harden T K
Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5'-monophosphate.
British journal of pharmacology 1996;118(8):1959-64.
1996: Van Schaick E A; Jacobson K A; Kim H O; IJzerman A P; Danhof M
Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats.
European journal of pharmacology 1996;308(3):311-4.
1996: van Rhee A M; Jiang J L; Melman N; Olah M E; Stiles G L; Jacobson K A
Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.
Journal of medicinal chemistry 1996;39(15):2980-9.
1996: Karton Y; Jiang J L; Ji X D; Melman N; Olah M E; Stiles G L; Jacobson K A
Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.
Journal of medicinal chemistry 1996;39(12):2293-301.
1996: Casavola V; Guerra L; Reshkin S J; Jacobson K A; Verrey F; Murer H
Effect of adenosine on Na+ and Cl- currents in A6 monolayers. Receptor localization and messenger involvement.
The Journal of membrane biology 1996;151(3):237-45.
1996: Liu G S; Jacobson K A; Downey J M
An irreversible A1-selective adenosine agonist preconditions rabbit heart.
The Canadian journal of cardiology 1996;12(5):517-21.
1996: Von Lubitz D K; Beenhakker M; Lin R C; Carter M F; Paul I A; Bischofberger N; Jacobson K A
Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist.
European journal of pharmacology 1996;302(1-3):43-8.
1996: Kim J; Jiang Q; Glashofer M; Yehle S; Wess J; Jacobson K A
Glutamate residues in the second extracellular loop of the human A2a adenosine receptor are required for ligand recognition.
Molecular pharmacology 1996;49(4):683-91.
1996: Jacobson K A; von Lubitz D K; Daly J W; Fredholm B B
Adenosine receptor ligands: differences with acute versus chronic treatment.
Trends in pharmacological sciences 1996;17(3):108-13.
1996: Kohno Y; Sei Y; Koshiba M; Kim H O; Jacobson K A
Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A(3) receptor agonists.
Biochemical and biophysical research communications 1996;219(3):904-10.
1996: Baraldi P G; Cacciari B; Spalluto G; Ji X D; Olah M E; Stiles G; Dionisotti S; Zocchi C; Ongini E; Jacobson K A
Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors.
Journal of medicinal chemistry 1996;39(3):802-6.
1996: Ji X D; Melman N; Jacobson K A
Interactions of flavonoids and other phytochemicals with adenosine receptors.
Journal of medicinal chemistry 1996;39(3):781-8.
1996: van Rhee A M; Siddiqi S M; Melman N; Shi D; Padgett W L; Daly J W; Jacobson K A
Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists.
Journal of medicinal chemistry 1996;39(2):398-406.
1996: el-Ani D; Jacobson K A; Shainberg A
Effects of theophylline and dibutyryl-cAMP on adenosine receptors and heart rate in cultured cardiocytes.
Journal of basic and clinical physiology and pharmacology 1996;7(4):347-62.
1995: Von Lubitz D K; Lin R C; Jacobson K A
Cerebral ischemia in gerbils: effects of acute and chronic treatment with adenosine A2A receptor agonist and antagonist.
European journal of pharmacology 1995;287(3):295-302.
1995: Palmer T M; Poucher S M; Jacobson K A; Stiles G L
125I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5] triazin-5-yl-amino]ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor.
Molecular pharmacology 1995;48(6):970-4.
1995: Abbracchio M P; Brambilla R; Ceruti S; Kim H O; von Lubitz D K; Jacobson K A; Cattabeni F
G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain.
Molecular pharmacology 1995;48(6):1038-45.
1995: Van Rhee A M; Fischer B; Van Galen P J; Jacobson K A
Modelling the P2Y purinoceptor using rhodopsin as template.
Drug design and discovery 1995;13(2):133-54.
1995: Boyer J L; O'Tuel J W; Fischer B; Jacobson K A; Harden T K
Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors.
British journal of pharmacology 1995;116(6):2611-6.
1995: Siddiqi S M; Pearlstein R A; Sanders L H; Jacobson K A
Comparative molecular field analysis of selective A3 adenosine receptor agonists.
Bioorganic & medicinal chemistry 1995;3(10):1331-43.
1995: Mathôt R A; Gubbens-Stibbe J M; Soudijn W; Jacobson K A; Ijzerman A P; Danhof M
Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine.
The Journal of pharmacology and experimental therapeutics 1995;275(1):245-53.
1995: Von Lubitz D K; Kim J; Beenhakker M; Carter M F; Lin R C; Meshulam Y; Daly J W; Shi D; Zhou L M; Jacobson K A
Chronic NMDA receptor stimulation: therapeutic implications of its effect on adenosine A1 receptors.
European journal of pharmacology 1995;283(1-3):185-92.
1995: von Lubitz D K; Carter M F; Beenhakker M; Lin R C; Jacobson K A
Adenosine: a prototherapeutic concept in neurodegeneration.
Annals of the New York Academy of Sciences 1995;765():163-78; discussion 196-7.
1995: Casavola V; Turner R J; Guay-Broder C; Jacobson K A; Eidelman O; Pollard H B
CPX, a selective A1-adenosine-receptor antagonist, regulates intracellular pH in cystic fibrosis cells.
The American journal of physiology 1995;269(1 Pt 1):C226-33.
1995: Jacobson K A; Guay-Broder C; van Galen P J; Gallo-Rodriguez C; Melman N; Jacobson M A; Eidelman O; Pollard H B
Stimulation by alkylxanthines of chloride efflux in CFPAC-1 cells does not involve A1 adenosine receptors.
Biochemistry 1995;34(28):9088-94.
1995: Guay-Broder C; Jacobson K A; Barnoy S; Cabantchik Z I; Guggino W B; Zeitlin P L; Turner R J; Vergara L; Eidelman O; Pollard H B
A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator delta F508 mutation.
Biochemistry 1995;34(28):9079-87.
1995: Kim J; Wess J; van Rhee A M; Schöneberg T; Jacobson K A
Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor.
The Journal of biological chemistry 1995;270(23):13987-97.
1995: Jacobson K A; Siddiqi S M; Olah M E; Ji X D; Melman N; Bellamkonda K; Meshulam Y; Stiles G L; Kim H O
Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors.
Journal of medicinal chemistry 1995;38(10):1720-35.
1995: Jacobson K A; Fischer B; Ji X D
"Cleavable trifunctional" approach to receptor affinity labeling: chemical regeneration of binding to A1-adenosine receptors.
Bioconjugate chemistry 1995;6(3):255-63.
1995: Siddiqi S M; Jacobson K A; Esker J L; Olah M E; Ji X D; Melman N; Tiwari K N; Secrist J A; Schneller S W; Cristalli G
Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.
Journal of medicinal chemistry 1995;38(7):1174-88.
1995: Ahmed A H; Jacobson K A; Kim J; Heppel L A
Presence of both A1 and A2a adenosine receptors in human cells and their interaction.
Biochemical and biophysical research communications 1995;208(2):871-8.
1995: Von Lubitz D K; Carter M F; Deutsch S I; Lin R C; Mastropaolo J; Meshulam Y; Jacobson K A
The effects of adenosine A3 receptor stimulation on seizures in mice.
European journal of pharmacology 1995;275(1):23-9.
1995: Jacobson K A; Fischer B; van Rhee A M
Molecular probes for muscarinic receptors: functionalized congeners of selective muscarinic antagonists.
Life sciences 1995;56(11-12):823-30.
1995: el-Ani D; Jacobson K A; Shainberg A
Regulation of adenosine receptors in cultured heart cells.
Advances in experimental medicine and biology 1995;382():205-15.
1994: Kim H O; Ji X D; Melman N; Olah M E; Stiles G L; Jacobson K A
Selective ligands for rat A3 adenosine receptors: structure-activity relationships of 1,3-dialkylxanthine 7-riboside derivatives.
Journal of medicinal chemistry 1994;37(23):4020-30.
1994: Shi D; Nikodijevic O; Jacobson K A; Daly J W
Effects of chronic caffeine on adenosine, dopamine and acetylcholine systems in mice.
Archives internationales de pharmacodynamie et de thérapie 1994;328(3):261-87.
1994: Kim H O; Ji X D; Siddiqi S M; Olah M E; Stiles G L; Jacobson K A
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.
Journal of medicinal chemistry 1994;37(21):3614-21.
1994: Olah M E; Jacobson K A; Stiles G L
Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors.
The Journal of biological chemistry 1994;269(40):24692-8.
1994: Boyer J L; Zohn I E; Jacobson K A; Harden T K
Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors.
British journal of pharmacology 1994;113(2):614-20.
1994: Kim H O; Ji X D; Melman N; Olah M E; Stiles G L; Jacobson K A
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.
Journal of medicinal chemistry 1994;37(20):3373-82.
1994: Von Lubitz D K; Lin R C; Popik P; Carter M F; Jacobson K A
Adenosine A3 receptor stimulation and cerebral ischemia.
European journal of pharmacology 1994;263(1-2):59-67.
1994: el-Ani D; Jacobson K A; Shainberg A
Characterization of adenosine receptors in intact cultured heart cells.
Biochemical pharmacology 1994;48(4):727-35.
1994: Ji X D; Gallo-Rodriguez C; Jacobson K A
A selective agonist affinity label for A3 adenosine receptors.
Biochemical and biophysical research communications 1994;203(1):570-6.
1994: Bo X; Fischer B; Maillard M; Jacobson K A; Burnstock G
Comparative studies on the affinities of ATP derivatives for P2x-purinoceptors in rat urinary bladder.
British journal of pharmacology 1994;112(4):1151-9.
1994: Olah M E; Jacobson K A; Stiles G L
Identification of an adenosine receptor domain specifically involved in binding of 5'-substituted adenosine agonists.
The Journal of biological chemistry 1994;269(27):18016-20.
1994: van Galen P J; van Bergen A H; Gallo-Rodriguez C; Melman N; Olah M E; IJzerman A P; Stiles G L; Jacobson K A
A binding site model and structure-activity relationships for the rat A3 adenosine receptor.
Molecular pharmacology 1994;45(6):1101-11.
1994: Palmer T M; Gettys T W; Jacobson K A; Stiles G L
Desensitization of the canine A2a adenosine receptor: delineation of multiple processes.
Molecular pharmacology 1994;45(6):1082-94.
1994: Fredholm B B; Abbracchio M P; Burnstock G; Daly J W; Harden T K; Jacobson K A; Leff P; Williams M
Nomenclature and classification of purinoceptors.
Pharmacological reviews 1994;46(2):143-56.
1994: IJzerman A P; van der Wenden E M; van Galen P J; Jacobson K A
Molecular modeling of adenosine receptors. The ligand binding site on the rat adenosine A2A receptor.
European journal of pharmacology 1994;268(1):95-104.
1994: Olah M E; Gallo-Rodriguez C; Jacobson K A; Stiles G L
125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.
Molecular pharmacology 1994;45(5):978-82.
1994: Von Lubitz D K; Lin R C; Melman N; Ji X D; Carter M F; Jacobson K A
Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia.
European journal of pharmacology 1994;256(2):161-7.
1994: Von Lubitz D K; Paul I A; Ji X D; Carter M; Jacobson K A
Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice.
European journal of pharmacology 1994;253(1-2):95-9.
1994: Maillard M C; Nikodijevic O; LaNoue K F; Berkich D; Ji X D; Bartus R; Jacobson K A
Adenosine receptor prodrugs: synthesis and biological activity of derivatives of potent, A1-selective agonists.
Journal of pharmaceutical sciences 1994;83(1):46-53.
1993: Jacobson K A; Nikodijevic O; Shi D; Gallo-Rodriguez C; Olah M E; Stiles G L; Daly J W
A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.
FEBS letters 1993;336(1):57-60.
1993: Von Lubitz D K; Paul I A; Bartus R T; Jacobson K A
Effects of chronic administration of adenosine A1 receptor agonist and antagonist on spatial learning and memory.
European journal of pharmacology 1993;249(3):271-80.
1993: Von Lubitz D K; Paul I A; Carter M; Jacobson K A
Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice.
European journal of pharmacology 1993;249(3):265-70.
1993: Fischer B; Boyer J L; Hoyle C H; Ziganshin A U; Brizzolara A L; Knight G E; Zimmet J; Burnstock G; Harden T K; Jacobson K A
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate.
Journal of medicinal chemistry 1993;36(24):3937-46.
1993: Jacobson K A; Shi D; Gallo-Rodriguez C; Manning M; Müller C; Daly J W; Neumeyer J L; Kiriasis L; Pfleiderer W
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.
Journal of medicinal chemistry 1993;36(18):2639-44.
1993: Ji X D; Jacobson K A
Solubilized rabbit striatal A2a-adenosine receptors: stability and antagonist binding.
Archives of biochemistry and biophysics 1993;305(2):611-7.
1993: Shi D; Nikodijevic O; Jacobson K A; Daly J W
Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain.
Cellular and molecular neurobiology 1993;13(3):247-61.
1993: Jacobson K A; Gallo-Rodriguez C; Melman N; Fischer B; Maillard M; van Bergen A; van Galen P J; Karton Y
Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists.
Journal of medicinal chemistry 1993;36(10):1333-42.
1993: Jacobson K A; Nikodijevic O; Padgett W L; Gallo-Rodriguez C; Maillard M; Daly J W
8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo.
FEBS letters 1993;323(1-2):141-4.
1993: Niiya K; Jacobson K A; Silvia S K; Olsson R A
Covalent binding of a selective agonist irreversibly activates guinea pig coronary artery A2 adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1993;347(5):521-6.
1993: Nikodijevic O; Jacobson K A; Daly J W
Locomotor activity in mice during chronic treatment with caffeine and withdrawal.
Pharmacology, biochemistry, and behavior 1993;44(1):199-216.
1992: Jacobson K A; Nikodijevic O; Ji X D; Berkich D A; Eveleth D; Dean R L; Hiramatsu K; Kassell N F; van Galen P J; Lee K S
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.
Journal of medicinal chemistry 1992;35(22):4143-9.
1992: van Galen P J; Stiles G L; Michaels G; Jacobson K A
Adenosine A1 and A2 receptors: structure--function relationships.
Medicinal research reviews 1992;12(5):423-71.
1992: Palmer T M; Jacobson K A; Stiles G L
Immunological identification of A2 adenosine receptors by two antipeptide antibody preparations.
Molecular pharmacology 1992;42(3):391-7.
1992: Jacobson K A; Stiles G L; Ji X D
Chemical modification and irreversible inhibition of striatal A2a adenosine receptors.
Molecular pharmacology 1992;42(1):123-33.
1992: Eastman R C; Carson R E; Jacobson K A; Shai Y; Channing M A; Dunn B B; Bacher J D; Baas E; Jones E; Kirk K L
In vivo imaging of insulin receptors in monkeys using 18F-labeled insulin and positron emission tomography.
Diabetes 1992;41(7):855-60.
1992: Eidelman O; Guay-Broder C; van Galen P J; Jacobson K A; Fox C; Turner R J; Cabantchik Z I; Pollard H B
A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5562-6.
1992: Olah M E; Ren H; Ostrowski J; Jacobson K A; Stiles G L
Cloning, expression, and characterization of the unique bovine A1 adenosine receptor. Studies on the ligand binding site by site-directed mutagenesis.
The Journal of biological chemistry 1992;267(15):10764-70.
1992: Karton Y; Baumgold J; Handen J S; Jacobson K A
Molecular probes for muscarinic receptors: derivatives of the M1-antagonist telenzepine.
Bioconjugate chemistry 1992;3(3):234-40.
1992: Dennis D; Jacobson K; Belardinelli L
Evidence of spare A1-adenosine receptors in guinea pig atrioventricular node.
The American journal of physiology 1992;262(3 Pt 2):H661-71.
1992: Jacobson K A; van Galen P J; Williams M
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.
Journal of medicinal chemistry 1992;35(3):407-22.
1992: Baumgold J; Nikodijevic O; Jacobson K A
Penetration of adenosine antagonists into mouse brain as determined by ex vivo binding.
Biochemical pharmacology 1992;43(4):889-94.
1992: Hide I; Padgett W L; Jacobson K A; Daly J W
A2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase.
Molecular pharmacology 1992;41(2):352-9.
1992: Baumgold J; Karton Y; Malka N; Jacobson K A
High affinity acylating antagonists for muscarinic receptors.
Life sciences 1992;51(5):345-51.
1992: Ji X D; Stiles G L; van Galen P J; Jacobson K A
Characterization of human striatal A2-adenosine receptors using radioligand binding and photoaffinity labeling.
Journal of receptor research 1992;12(2):149-69.
1992: IJzerman A P; Van Galen P J; Jacobson K A
Molecular modeling of adenosine receptors. I. The ligand binding site on the A1 receptor.
Drug design and discovery 1992;9(1):49-67.
1991: Leung E; Jacobson K A; Green R D
Apparent heterogeneity of cardiac A1 adenosine receptors as revealed by radioligand binding experiments on N-ethylmaleimide-treated membranes.
Naunyn-Schmiedeberg's archives of pharmacology 1991;344(6):639-44.
1991: Ramkumar V; Olah M E; Jacobson K A; Stiles G L
Distinct pathways of desensitization of A1- and A2-adenosine receptors in DDT1 MF-2 cells.
Molecular pharmacology 1991;40(5):639-47.
1991: Nikodijevic O; Sarges R; Daly J W; Jacobson K A
Behavioral effects of A1- and A2-selective adenosine agonists and antagonists: evidence for synergism and antagonism.
The Journal of pharmacology and experimental therapeutics 1991;259(1):286-94.
1991: Karton Y; Bradbury B J; Baumgold J; Paek R; Jacobson K A
Functionalized congener approach to muscarinic antagonists: analogues of pirenzepine.
Journal of medicinal chemistry 1991;34(7):2133-45.
1991: Jacobson K A; Trivedi B K; Churchill P C; Williams M
Novel therapeutics acting via purine receptors.
Biochemical pharmacology 1991;41(10):1399-410.
1991: Boring D L; Ji X D; Zimmet J; Taylor K E; Stiles G L; Jacobson K A
Trifunctional agents as a design strategy for tailoring ligand properties: irreversible inhibitors of A1 adenosine receptors.
Bioconjugate chemistry 1991;2(2):77-88.
1991: Bradbury B J; Baumgold J; Paek R; Kammula U; Zimmet J; Jacobson K A
Muscarinic receptor binding and activation of second messengers by substituted N-methyl-N-[4-(1-azacycloalkyl)-2-butynyl]acetamides.
Journal of medicinal chemistry 1991;34(3):1073-9.
1991: Nanoff C; Jacobson K A; Stiles G L
The A2 adenosine receptor: guanine nucleotide modulation of agonist binding is enhanced by proteolysis.
Molecular pharmacology 1991;39(2):130-5.
1990: Olah M E; Jacobson K A; Stiles G L
Purification and characterization of bovine cerebral cortex A1 adenosine receptor.
Archives of biochemistry and biophysics 1990;283(2):440-6.
1990: Lee T F; Li D J; Jacobson K A; Wang L C
Improvement of cold tolerance by selective A1 adenosine receptor antagonists in rats.
Pharmacology, biochemistry, and behavior 1990;37(1):107-12.
1990: Barrington W W; Jacobson K A; Stiles G L
Glycoprotein nature of the A2-adenosine receptor binding subunit.
Molecular pharmacology 1990;38(2):177-83.
1990: Leung E; Jacobson K A; Green R D
Analysis of agonist-antagonist interactions at A1 adenosine receptors.
Molecular pharmacology 1990;38(1):72-83.
1990: Nikodijevic O; Daly J W; Jacobson K A
Characterization of the locomotor depression produced by an A2-selective adenosine agonist.
FEBS letters 1990;261(1):67-70.
1990: Ramkumar V; Barrington W W; Jacobson K A; Stiles G L
Demonstration of both A1 and A2 adenosine receptors in DDT1 MF-2 smooth muscle cells.
Molecular pharmacology 1990;37(2):149-56.
1990: Bradbury B J; Baumgold J; Jacobson K A
Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides.
Journal of medicinal chemistry 1990;33(2):741-8.
1990: Jacobson K A
Probing adenosine receptors using biotinylated purine derivatives.
Methods in enzymology 1990;184():668-71.
1989: Jacobson K A; Pannell L K; Ji X D; Jarvis M F; Williams M; Hutchison A J; Barrington W W; Stiles G L
Agonist derived molecular probes for A2 adenosine receptors.
Journal of molecular recognition : JMR 1989;2(4):170-8.
1989: Olah M E; Jacobson K A; Stiles G L
Affinity chromatography of the bovine cerebral cortex A1 adenosine receptor.
FEBS letters 1989;257(2):292-6.
1989: Barrington W W; Jacobson K A; Hutchison A J; Williams M; Stiles G L
Identification of the A2 adenosine receptor binding subunit by photoaffinity crosslinking.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6572-6.
1989: Jacobson K A; Kiriasis L; Barone S; Bradbury B J; Kammula U; Campagne J M; Secunda S; Daly J W; Neumeyer J L; Pfleiderer W
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.
Journal of medicinal chemistry 1989;32(8):1873-9.
1989: Barrington W W; Jacobson K A; Stiles G L
Demonstration of distinct agonist and antagonist conformations of the A1 adenosine receptor.
The Journal of biological chemistry 1989;264(22):13157-64.
1989: Barone S; Churchill P C; Jacobson K A
Adenosine receptor prodrugs: towards kidney-selective dialkylxanthines.
The Journal of pharmacology and experimental therapeutics 1989;250(1):79-85.
1989: Jacobson K A; Barone S; Kammula U; Stiles G L
Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors.
Journal of medicinal chemistry 1989;32(5):1043-51.
1989: Shai Y; Kirk K L; Channing M A; Dunn B B; Lesniak M A; Eastman R C; Finn R D; Roth J; Jacobson K A
18F-labeled insulin: a prosthetic group methodology for incorporation of a positron emitter into peptides and proteins.
Biochemistry 1989;28(11):4801-6.
1989: Morgan P F; Deckert J; Jacobson K A; Marangos P J; Daly J W
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
Life sciences 1989;45(8):719-28.
1988: Stiles G L; Jacobson K A
High affinity acylating antagonists for the A1 adenosine receptor: identification of binding subunit.
Molecular pharmacology 1988;34(6):724-8.
1988: Jacobson K A; de la Cruz R; Schulick R; Kiriasis L; Padgett W; Pfleiderer W; Kirk K L; Neumeyer J L; Daly J W
8-Substituted xanthines as antagonists at A1- and A2-adenosine receptors.
Biochemical pharmacology 1988;37(19):3653-61.
1988: Ramkumar V; Bumgarner J R; Jacobson K A; Stiles G L
Multiple components of the A1 adenosine receptor-adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion.
The Journal of clinical investigation 1988;82(1):242-7.
1988: Deckert J; Morgan P F; Bisserbe J C; Jacobson K A; Kirk K L; Daly J W; Marangos P J
Autoradiographic localization of mouse brain adenosine receptors with an antagonist ([3H]xanthine amine congener) ligand probe.
Neuroscience letters 1988;86(2):121-6.
1988: Daly J W; Hong O; Padgett W L; Shamim M T; Jacobson K A; Ukena D
Non-xanthine heterocycles: activity as antagonists of A1- and A2-adenosine receptors.
Biochemical pharmacology 1988;37(4):655-64.
1987: Jacobson K A; Zimmet J; Schulick R; Barone S; Daly J W; Kirk K L
Adenosine analogs with covalently attached lipids have enhanced potency at A1-adenosine receptors.
FEBS letters 1987;225(1-2):97-102.
1987: Churchill P C; Jacobson K A; Churchill M C
XAC, a functionalized congener of 1,3-dialkylxanthine, antagonizes A1 adenosine receptor-mediated inhibition of renin secretion in vitro.
Archives internationales de pharmacodynamie et de thérapie 1987;290(2):293-301.
1987: Jarvis M F; Jacobson K A; Williams M
Autoradiographic localization of adenosine A1 receptors in rat brain using [3H]XCC, a functionalized congener of 1,3-dipropylxanthine.
Neuroscience letters 1987;81(1-2):69-74.
1987: Collis M G; Jacobson K A; Tomkins D M
Apparent affinity of some 8-phenyl-substituted xanthines at adenosine receptors in guinea-pig aorta and atria.
British journal of pharmacology 1987;92(1):69-75.
1987: Evoniuk G; Jacobson K A; Shamim M T; Daly J W; Wurtman R J
A1- and A2-selective adenosine antagonists: in vivo characterization of cardiovascular effects.
The Journal of pharmacology and experimental therapeutics 1987;242(3):882-7.
1987: Stiles G L; Jacobson K A
A new high affinity, iodinated adenosine receptor antagonist as a radioligand/photoaffinity crosslinking probe.
Molecular pharmacology 1987;32(1):184-8.
1987: Hu P S; Lindgren E; Jacobson K A; Fredholm B B
Interaction of dihydropyridine calcium channel agonists and antagonists with adenosine receptors.
Pharmacology & toxicology 1987;61(2):121-5.
1987: Jacobson K A; Lipkowski A W; Moody T W; Padgett W; Pijl E; Kirk K L; Daly J W
Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors.
Journal of medicinal chemistry 1987;30(8):1529-32.
1987: Jacobson K A; Ukena D; Padgett W; Kirk K L; Daly J W
Molecular probes for extracellular adenosine receptors.
Biochemical pharmacology 1987;36(10):1697-707.
1987: Marshall T H; Jacobson K A; Kirk K L; Linnoila M
Liquid chromatographic assay for cerebrospinal fluid normetanephrine.
Life sciences 1987;40(15):1513-21.
1987: Fredholm B B; Jacobson K A; Jonzon B; Kirk K L; Li Y O; Daly J W
Evidence that a novel 8-phenyl-substituted xanthine derivative is a cardioselective adenosine receptor antagonist in vivo.
Journal of cardiovascular pharmacology 1987;9(4):396-400.
1987: Gusovsky F; Jacobson K A; Kirk K L; Marshall T; Linnoila M
New high-performance liquid chromatographic procedure for the detection and quantification of beta-phenylethylamine.
Journal of chromatography 1987;415(1):124-8.
1987: Rossi N F; Churchill P C; Jacobson K A; Leahy A E
Further characterization of the renovascular effects of N6-cyclohexyladenosine in the isolated perfused rat kidney.
The Journal of pharmacology and experimental therapeutics 1987;240(3):911-5.
1987: Jacobson K A; Ukena D; Padgett W; Daly J W; Kirk K L
Xanthine functionalized congeners as potent ligands at A2-adenosine receptors.
Journal of medicinal chemistry 1987;30(1):211-4.
1987: Daly J W; Jacobson K A; Ukena D
Adenosine receptors: development of selective agonists and antagonists.
Progress in clinical and biological research 1987;230():41-63.
1986: Ukena D; Jacobson K A; Padgett W L; Ayala C; Shamim M T; Kirk K L; Olsson R O; Daly J W
Species differences in structure-activity relationships of adenosine agonists and xanthine antagonists at brain A1 adenosine receptors.
FEBS letters 1986;209(1):122-8.
1986: Jacobson K A; Ukena D; Kirk K L; Daly J W
[3H]xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):4089-93.
1986: Jacobson K A; Yamada N; Kirk K L; Daly J W; Olsson R A
N6-functionalized congeners of adenosine with high potency at A2-adenosine receptors: potential ligands for affinity chromatography.
Biochemical and biophysical research communications 1986;136(3):1097-102.
1986: Ukena D; Jacobson K A; Kirk K L; Daly J W
A [3H]amine congener of 1,3-dipropyl-8-phenylxanthine. A new radioligand for A2 adenosine receptors of human platelets.
FEBS letters 1986;199(2):269-74.
1986: Ukena D; Daly J W; Kirk K L; Jacobson K A
Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells.
Life sciences 1986;38(9):797-807.
1986: Linnoila M; Jacobson K A; Marshall T H; Miller T L; Kirk K L
Liquid chromatographic assay for cerebrospinal fluid serotonin.
Life sciences 1986;38(8):687-94.
1986: Jacobson K A; Kirk K L; Padgett W L; Daly J W
A functionalized congener approach to adenosine receptor antagonists: amino acid conjugates of 1,3-dipropylxanthine.
Molecular pharmacology 1986;29(2):126-33.
1986: Mine K; Jacobson K A; Kirk K L; Kitajima Y; Linnoila M
Simultaneous determination of histamine and N tau-methylhistamine with high-performance liquid chromatography using electrochemical detection.
Analytical biochemistry 1986;152(1):127-35.
1985: Jacobson K A; Marshall T; Mine K; Kirk K L; Linnoila M
Electrochemical detection of biogenic amines following acylation by N-hydroxysuccinimide esters.
FEBS letters 1985;188(2):307-11.
1985: Jacobson K A; Kirk K L; Padgett W L; Daly J W
Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors.
Journal of medicinal chemistry 1985;28(9):1341-6.
1985: Jacobson K A; Kirk K L; Padgett W L; Daly J W
Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.
Journal of medicinal chemistry 1985;28(9):1334-40.
1985: Jacobson K A; Kirk K L; Padgett W; Daly J W
Probing the adenosine receptor with adenosine and xanthine biotin conjugates.
FEBS letters 1985;184(1):30-5.
1983: Jacobson K A; Patchornik A
Visual methods for the nanomolar detection of electrophilic reagents.
Journal of biochemical and biophysical methods 1983;8(3):213-22.
1983: Rosenkranz R P; Hoffman B B; Jacobson K A; Verlander M S; Klevans L; O'Donnell M; Goodman M; Melmon K L
Conjugates of catecholamines. II. In vitro and in vivo pharmacological activity of N-alkyl-functionalized carboxylic acid congeners and amides related to isoproterenol.
Molecular pharmacology 1983;24(3):429-35.
1983: Rosenkranz R P; Jacobson K A; Verlander M S; Klevans L; O'Donnell M; Goodman M; Melmon K L
Conjugates of catecholamines. IV. In vitro and in vivo pharmacological activity of monodisperse oligopeptide conjugates.
The Journal of pharmacology and experimental therapeutics 1983;227(2):267-73.
1983: Jacobson K A; Verlander M S; Rosenkranz R P; Melmon K L; Goodman M
Conjugates of catecholamines. III. Synthesis and characterization of monodisperse oligopeptides conjugates related to isoproterenol.
International journal of peptide and protein research 1983;22(3):284-304.
1983: Jacobson K A; Marr-Leisy D; Rosenkranz R P; Verlander M S; Melmon K L; Goodman M
Conjugates of catecholamines. 1. N-alkyl-functionalized carboxylic acid congeners and amides related to isoproterenol.
Journal of medicinal chemistry 1983;26(4):492-9.
1983: Verlander M S; Jacobson K A; Rosenkranz R P; Melmon K L; Goodman M
Some novel approaches to the design and synthesis of peptide-catecholamine conjugates.
Biopolymers 1983;22(1):531-45.
1983: Rosenkranz R P; Jacobson K A; Verlander M S; Goodman M; Melmon K L
Betamimetic activity of peptide catecholamine conjugates.
Proceedings of the Western Pharmacology Society 1983;26():381-5.
1982: Rosenkranz R P; Jacobson K A; Goodman M; Verlander M; Melmon K L
In vitro and in vivo betamimetic activity of congeners of isoproterenol.
Proceedings of the Western Pharmacology Society 1982;25():19-23.

Sign-in to see more