Agapios Sachinidis

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Mariappan Devi; Niemann Rabea; Gajewski Martin; Winkler Johannes; Chen Shuhua; Choorapoikayil Suma; Bitzer Marco; Schulz Herbert; Hescheler Jürgen; Sachinidis Agapios
Somitovasculin, a novel endothelial-specific transcript involved in the vasculature development.
Ding Li; Paszkowski-Rogacz Maciej; Nitzsche Anja; Slabicki Mikolaj Michal; Heninger Anne-Kristin; de Vries Ingrid; Kittler Ralf; Junqueira Magno; Shevchenko Andrej; Schulz Herbert; Hubner Norbert; Doss Michael Xavier; Sachinidis Agapios; Hescheler Juergen; Iacone Roberto; Anastassiadis Konstantinos; Stewart A Francis; Pisabarro M Teresa; Caldarelli Antonio; Poser Ina; Theis Mirko; Buchholz Frank
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Mariappan Devi; Winkler Johannes; Chen Shuhua; Schulz Herbert; Hescheler Jürgen; Sachinidis Agapios
Transcriptional profiling of CD31(+) cells isolated from murine embryonic stem cells.

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All Publications

2009: Mariappan Devi; Niemann Rabea; Gajewski Martin; Winkler Johannes; Chen Shuhua; Choorapoikayil Suma; Bitzer Marco; Schulz Herbert; Hescheler Jürgen; Sachinidis Agapios
Somitovasculin, a novel endothelial-specific transcript involved in the vasculature development.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(11):1823-9.
2009: Ding Li; Paszkowski-Rogacz Maciej; Nitzsche Anja; Slabicki Mikolaj Michal; Heninger Anne-Kristin; de Vries Ingrid; Kittler Ralf; Junqueira Magno; Shevchenko Andrej; Schulz Herbert; Hubner Norbert; Doss Michael Xavier; Sachinidis Agapios; Hescheler Juergen; Iacone Roberto; Anastassiadis Konstantinos; Stewart A Francis; Pisabarro M Teresa; Caldarelli Antonio; Poser Ina; Theis Mirko; Buchholz Frank
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Cell stem cell 2009;4(5):403-15.
2009: Mariappan Devi; Winkler Johannes; Chen Shuhua; Schulz Herbert; Hescheler Jürgen; Sachinidis Agapios
Transcriptional profiling of CD31(+) cells isolated from murine embryonic stem cells.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(2):243-60.
2009: Potta Shiva Prasad; Liang Huamin; Pfannkuche Kurt; Winkler Johannes; Chen Shuhua; Doss Michael Xavier; Obernier Kirsten; Kamisetti Naidu; Schulz Herbert; Hübner Norbert; Hescheler Jürgen; Sachinidis Agapios
Functional characterization and transcriptome analysis of embryonic stem cell-derived contractile smooth muscle cells.
Hypertension 2009;53(2):196-204.
2009: Jagtap Smita; Meganathan Kesavan; Wagh Vilas; Winkler Johannes; Hescheler Jürgen; Sachinidis Agapios
Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases.
Current medicinal chemistry 2009;16(12):1451-62.
2009: Trouillas Marina; Saucourt Claire; Guillotin Bertrand; Gauthereau Xavier; Ding Li; Buchholz Frank; Doss Michael Xavier; Sachinidis Agapios; Hescheler Jurgen; Hummel Oliver; Huebner Norbert; Kolde Raivo; Vilo Jaak; Schulz Herbert; Boeuf Hélène
Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives.
BMC genomics 2009;10():73.
2008: Doss Michael Xavier; Sachinidis Agapios; Hescheler Jürgen
Human ES cell derived cardiomyocytes for cell replacement therapy: a current update.
The Chinese journal of physiology 2008;51(4):226-9.
2008: Sachinidis Agapios; Sotiriadou Isaia; Seelig Bianca; Berkessel Albrecht; Hescheler Jürgen
A chemical genetics approach for specific differentiation of stem cells to somatic cells: a new promising therapeutical approach.
Combinatorial chemistry & high throughput screening 2008;11(1):70-82.
2008: Pfannkuche Kurt; Wunderlich Frank Thomas; Doss Michael Xavier; Spitkovsky Dimitry; Reppel Michael; Sachinidis Agapios; Hescheler Jürgen
Generation of a double-fluorescent double-selectable Cre/loxP indicator vector for monitoring of intracellular recombination events.
Nature protocols 2008;3(9):1510-26.
2007: Bentz Kristine; Molcanyi Marek; Riess Peter; Elbers Andrea; Pohl Esther; Sachinidis Agapios; Hescheler Jürgen; Neugebauer Edmund; Schäfer Ute
Embryonic stem cells produce neurotrophins in response to cerebral tissue extract: Cell line-dependent differences.
Journal of neuroscience research 2007;85(5):1057-64.
2007: Dardousis Kleomenis; Voolstra Chris; Roengvoraphoj Monic; Sekandarzad Asieb; Mesghenna Senait; Winkler Johannes; Ko Yon; Hescheler Jürgen; Sachinidis Agapios
Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):94-102.
2007: Chae Yeon Jeong; Kim Chan Hyung; Ha Tae Sun; Hescheler Jurgen; Ahn Hee Yul; Sachinidis Agapios
Epigallocatechin-3-O-gallate inhibits the angiotensin II-induced adhesion molecule expression in human umbilical vein endothelial cell via inhibition of MAPK pathways.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(6):859-66.
2007: Doss Michael Xavier; Chen Shuhua; Winkler Johannes; Hippler-Altenburg Rita; Odenthal Margareta; Wickenhauser Claudia; Balaraman Sridevi; Schulz Herbert; Hummel Oliver; Hübner Norbert; Ghosh-Choudhury Nandini; Sotiriadou Isaia; Hescheler Jürgen; Sachinidis Agapios
Transcriptomic and phenotypic analysis of murine embryonic stem cell derived BMP2+ lineage cells: an insight into mesodermal patterning.
Genome biology 2007;8(9):R184.
2007: Doss Michael Xavier; Winkler Johannes; Chen Shuhua; Hippler-Altenburg Rita; Sotiriadou Isaia; Halbach Marcel; Pfannkuche Kurt; Liang Huamin; Schulz Herbert; Hummel Oliver; Hübner Norbert; Rottscheidt Ruth; Hescheler Jürgen; Sachinidis Agapios
Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes.
Genome biology 2007;8(4):R56.
2006: Sachinidis Agapios; Schwengberg Silke; Hippler-Altenburg Rita; Mariappan Devi; Kamisetti Naidu; Seelig Bianca; Berkessel Albrecht; Hescheler Jurgen
Identification of small signalling molecules promoting cardiac-specific differentiation of mouse embryonic stem cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2006;18(6):303-14.
2006: Mariappan Devi; Winkler Johannes; Hescheler Jürgen; Sachinidis Agapios
Cardiovascular genomics: a current overview of in vivo and in vitro studies.
Stem cell reviews 2006;2(1):59-66.
2006: Hescheler Jürgen; Sachinidis Agapios; Chen Shuhua; Winkler Johannes
The FunGenES consortium: functional genomics in engineered embryonic stem cells.
Stem cell reviews 2006;2(1):1-4.
2006: Gissel Cornelia; Doss Michael Xavier; Hippler-Altenburg Rita; Hescheler Jürgen; Sachinidis Agapios
Generation and characterization of cardiomyocytes under serum-free conditions.
Methods in molecular biology (Clifton, N.J.) 2006;330():191-219.
2006: Mariappan Devi; Winkler Johannes; Parthiban Vijaya; Doss Michael Xavier; Hescheler Jürgen; Sachinidis Agapios
Dietary small molecules and large-scale gene expression studies: an experimental approach for understanding their beneficial effects on the development of malignant and non-malignant proliferative diseases.
Current medicinal chemistry 2006;13(13):1481-9.
2005: Gissel Cornelia; Voolstra Chris; Doss Michael Xavier; Koehler Christoph I; Winkler Johannes; Hescheler Jürgen; Sachinidis Agapios
An optimized embryonic stem cell model for consistent gene expression and developmental studies: a fundamental study.
Thrombosis and haemostasis 2005;94(4):719-27.
2005: Winkler Johannes; Hescheler Jürgen; Sachinidis Agapios
Embryonic stem cells for basic research and potential clinical applications in cardiology.
Biochimica et biophysica acta 2005;1740(2):240-8.
2005: Doss Michael Xavier; Potta Shiva Prasad; Hescheler Jürgen; Sachinidis Agapios
Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases.
The Journal of nutritional biochemistry 2005;16(5):259-66.
2005: Ko Yon; Hahn Tanja; Lu Hong; Ma Zhan Lu; Chen Jian; Rothe Marcus; Florin Alexandra; Fronhoffs Stefan; Albers Peter; Sachinidis Agapios; Vetter Hans; Kaminski Annette; Behrens Peter; Wellmann Axel; Wernert Nicolas
A novel component of the ubiquitin pathway, ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer.
International journal of molecular medicine 2005;15(2):183-96.
2004: Doss Michael Xavier; Koehler Christoph I; Gissel C; Hescheler Jürgen; Sachinidis Agapios
Embryonic stem cells: a promising tool for cell replacement therapy.
Journal of cellular and molecular medicine 2004;8(4):465-73.
2004: Gouni-Berthold Ioanna; Sachinidis Agapios
Possible non-classic intracellular and molecular mechanisms of LDL cholesterol action contributing to the development and progression of atherosclerosis.
Current vascular pharmacology 2004;2(4):363-70.
2004: Kim Dong-Woon; Park Young-Sun; Kim Young-Gyu; Piao Hainan; Kwon Jin-Sook; Hwang Kyung-Kuk; Youn Tae-Jin; Park Jong Bum; Yun Yeo-Pyo; Sachinidis Agapios; Kim Chan-Hyung; Cho Myeong-Chan; Ahn Hee-Yul
Local delivery of green tea catechins inhibits neointimal formation in the rat carotid artery injury model.
Heart and vessels 2004;19(5):242-7.
2004: McLoughlin Patricia; Roengvoraphoj Monic; Gissel Cornelia; Hescheler Jürgen; Certa Ulrich; Sachinidis Agapios
Transcriptional responses to epigallocatechin-3 gallate in HT 29 colon carcinoma spheroids.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(7):661-9.
2004: Zheng Ying; Song Hye Jin; Kim Chan Hyung; Kim Hun Sik; Kim Eung-Gook; Sachinidis Agapios; Ahn Hee Yul
Inhibitory effect of epigallocatechin 3-O-gallate on vascular smooth muscle cell hypertrophy induced by angiotensin II.
Journal of cardiovascular pharmacology 2004;43(2):200-8.
2004: Neuhaus Thomas; Pabst Stefan; Stier Sebastian; Weber Artur-Aron; Schrör Karsten; Sachinidis Agapios; Vetter Hans; Ko Yon D
Inhibition of the vascular-endothelial growth factor-induced intracellular signaling and mitogenesis of human endothelial cells by epigallocatechin-3 gallate.
European journal of pharmacology 2004;483(2-3):223-7.
2004: Weber Artur-Aron; Neuhaus Thomas; Skach Romanita Adriana; Hescheler Jürgen; Ahn Hee-Yul; Schrör Karsten; Ko Yon; Sachinidis Agapios
Mechanisms of the inhibitory effects of epigallocatechin-3 gallate on platelet-derived growth factor-BB-induced cell signaling and mitogenesis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):128-30.
2004: Gouni-Berthold Ioanna; Seewald Stefan; Hescheler Jürgen; Sachinidis Agapios
Regulation of mitogen-activated protein kinase cascades by low density lipoprotein and lysophosphatidic acid.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2004;14(3):167-76.
2004: Gouni-Berthold I; Sachinidis A
Molecular mechanisms explaining the preventive effects of catechins on the development of proliferative diseases.
Current pharmaceutical design 2004;10(11):1261-71.
2003: Neuhaus Thomas; Lutz Christoph; Stier Sebastian; Totzke Gudrun; Gruenewald Elisabeth; Fronhoffs Stefan; Sachinidis Agapios; Vetter Hans; Ko Yon D
The use of suppression subtractive hybridization for the study of SDF-1alpha induced gene-expression in human endothelial cells.
Molecular and cellular probes 2003;17(5):245-52.
2003: Sauer Heinrich; Wefer Katrin; Vetrugno Vito; Pocchiari Maurizio; Gissel Cornelia; Sachinidis Agapios; Hescheler Jürgen; Wartenberg Maria
Regulation of intrinsic prion protein by growth factors and TNF-alpha: the role of intracellular reactive oxygen species.
Free radical biology & medicine 2003;35(6):586-94.
2003: Sachinidis Agapios; Fleischmann Bernd K; Kolossov Eugen; Wartenberg Maria; Sauer Heinrich; Hescheler Jürgen
Cardiac specific differentiation of mouse embryonic stem cells.
Cardiovascular research 2003;58(2):278-91.
2003: Neuhaus Thomas; Stier Sebastian; Totzke Gudrun; Gruenewald Elisabeth; Fronhoffs Stefan; Sachinidis Agapios; Vetter Hans; Ko Yon D
Stromal cell-derived factor 1alpha (SDF-1alpha) induces gene-expression of early growth response-1 (Egr-1) and VEGF in human arterial endothelial cells and enhances VEGF induced cell proliferation.
Cell proliferation 2003;36(2):75-86.
2003: Sachinidis Agapios; Gissel Cornelia; Nierhoff Dirk; Hippler-Altenburg Rita; Sauer Henrich; Wartenberg Maria; Hescheler Jürgen
Identification of plateled-derived growth factor-BB as cardiogenesis-inducing factor in mouse embryonic stem cells under serum-free conditions.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2003;13(6):423-9.
2002: Sachinidis Agapios; Kolossov Eugen; Fleischmann Bernd K; Hescheler Jürgen
Generation of cardiomyocytes from embryonic stem cells experimental studies.
Herz 2002;27(7):589-97.
2002: Hoppe Jürgen; Kilic Mehtap; Hoppe Vivianne; Sachinidis Agapios; Kagerhuber Ulrike
Formation of caspase-3 complexes and fragmentation of caspase-12 during anisomycin-induced apoptosis in AKR-2B cells without aggregation of Apaf-1.
European journal of cell biology 2002;81(10):567-76.
2002: Gouni-Berthold Ioanna; Sachinidis Agapios
Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells?
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1477-87.
2002: Sachinidis Agapios; Skach Romanita Adriana; Seul Claudia; Ko Yon; Hescheler Jürgen; Ahn Hee-Yul; Fingerle Jürgen
Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(8):893-5.
2002: Fronhoffs S; Totzke G; Stier S; Wernert N; Rothe M; Brüning T; Koch B; Sachinidis A; Vetter H; Ko Y
A method for the rapid construction of cRNA standard curves in quantitative real-time reverse transcription polymerase chain reaction.
Molecular and cellular probes 2002;16(2):99-110.
2002: Wernert Nicolas; Justen Hans-Peter; Rothe Marcus; Behrens Peter; Dreschers Stephan; Neuhaus Thomas; Florin Alexandra; Sachinidis Agapios; Vetter Hans; Ko Yon
The Ets 1 transcription factor is upregulated during inflammatory angiogenesis in rheumatoid arthritis.
Journal of molecular medicine (Berlin, Germany) 2002;80(4):258-66.
2002: Nickenig Georg; Michaelsen Frank; Müller Cornelius; Berger Anja; Vogel Thomas; Sachinidis Agapios; Vetter Hans; Böhm Michael
Destabilization of AT(1) receptor mRNA by calreticulin.
Circulation research 2002;90(1):53-8.
2002: Landré Julien B P; Hewett Peter W; Olivot Jean-Marc; Friedl Peter; Ko Yon; Sachinidis Agapios; Moenner Michel
Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1).
Journal of cellular biochemistry 2002;86(3):540-52.
2001: Gouni-Berthold I; Seul C; Ko Y; Hescheler J; Sachinidis A
Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway.
Hypertension 2001;38(5):1030-7.
2001: Kettenhofen R; Hoppe J; Eberhard G; Seul C; Ko Y; Sachinidis A
Regulation of Gadd45a mRNA expression in vascular smooth muscle under growth and stress conditions.
Cellular signalling 2001;13(11):787-99.
2001: Fronhoffs S; Brüning T; Ortiz-Pallardo E; Bröde P; Koch B; Harth V; Sachinidis A; Bolt H M; Herberhold C; Vetter H; Ko Y
Real-time PCR analysis of the N-acetyltransferase NAT1 allele *3, *4, *10, *11, *14 and *17 polymorphism in squamous cell cancer of head and neck.
Carcinogenesis 2001;22(9):1405-12.
2001: Totzke G; Metzner C; Ulrich-Merzenich G; Ko Y; Sachinidis A; Vetter H
Effect of vitamin E and vitamin C on the DNA synthesis of human umbilical arterial endothelial cells.
European journal of nutrition 2001;40(3):121-6.
2001: Lottermoser K; Düsing R; Ervens P; Koch B; Brüning T; Sachinidis A; Vetter H; Ko Y
The plasminogen activator inhibitor 1 4G/5G polymorphism is not associated with longevity: a study in octogenarians.
Journal of molecular medicine (Berlin, Germany) 2001;79(5-6):289-93.
2001: Ko Y; Abel J; Harth V; Bröde P; Antony C; Donat S; Fischer H P; Ortiz-Pallardo M E; Thier R; Sachinidis A; Vetter H; Bolt H M; Herberhold C; Brüning T
Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.
Cancer research 2001;61(11):4398-404.
2001: Schmitz U; Thömmes K; Beier I; Wagner W; Sachinidis A; Düsing R; Vetter H
Angiotensin II-induced stimulation of p21-activated kinase and c-Jun NH2-terminal kinase is mediated by Rac1 and Nck.
The Journal of biological chemistry 2001;276(25):22003-10.
2001: Gouni-Berthold I; Berthold H K; Seul C; Ko Y; Vetter H; Sachinidis A
Effects of authentic and VLDL hydrolysis-derived fatty acids on vascular smooth muscle cell growth.
British journal of pharmacology 2001;132(8):1725-34.
2001: Harth V; Brüning T; Abel J; Koch B; Berg I; Sachinidis A; Bolt H M; Vetter H; Ko Y
Real-time genotyping of cytochrome P4501A1 A4889G and T6235C polymorphisms.
Molecular and cellular probes 2001;15(2):93-7.
2001: Gouni-Berthold I; Berthold H K; Weber A A; Ko Y; Seul C; Vetter H; Sachinidis A
Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway.
Naunyn-Schmiedeberg's archives of pharmacology 2001;363(2):215-21.
2001: Gouni-Berthold I; Berthold H K; Weber A A; Seul C; Vetter H; Sachinidis A
Troglitazone and rosiglitazone inhibit the low density lipoprotein-induced vascular smooth muscle cell growth.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2001;109(4):203-9.
2000: Gouni-Berthold I; Berthold H K; Seewald S; Seul C; Ko Y; Vetter H; Sachinidis A
Short-term stimulation of vascular smooth muscle cells with platelet-derived growth factor (PDGF)-BB and angiotensin II induces.
Scandinavian journal of clinical and laboratory investigation 2000;60(8):723-31.
2000: Sachinidis A; Seul C; Gouni-Berthold I; Seewald S; Ko Y; Vetter H; Fingerle J; Hoppe J
Cholera toxin treatment of vascular smooth muscle cells decreases smooth muscle alpha-actin content and abolishes the platelet-derived growth factor-BB-stimulated DNA synthesis.
British journal of pharmacology 2000;130(7):1561-70.
2000: Ko Y; Grünewald E; Totzke G; Klinz M; Fronhoffs S; Gouni-Berthold I; Sachinidis A; Vetter H
High percentage of false-positive results of cytokeratin 19 RT-PCR in blood: a model for the analysis of illegitimate gene expression.
Oncology 2000;59(1):81-8.
2000: Ko Y; Koch B; Harth V; Sachinidis A; Thier R; Vetter H; Bolt H M; Brüning T
Rapid analysis of GSTM1, GSTT1 and GSTP1 polymorphisms using real-time polymerase chain reaction.
Pharmacogenetics 2000;10(3):271-4.
2000: Sachinidis A; Seul C; Seewald S; Ahn H; Ko Y; Vetter H
Green tea compounds inhibit tyrosine phosphorylation of PDGF beta-receptor and transformation of A172 human glioblastoma.
FEBS letters 2000;471(1):51-5.
2000: Neuhaus T; Totzke G; Gruenewald E; Juesten H P; Sachinidis A; Vetter H; Ko Y
Tumour necrosis factor-alpha gene expression and production in human umbilical arterial endothelial cells.
Clinical science (London, England : 1979) 2000;98(4):461-70.
2000: Ortiz-Pallardó M E; Ko Y; Sachinidis A; Vetter H; Fischer H P; Zhou H
Detection of alpha-1-antitrypsin PiZ individuals by SSCP and DNA sequencing in formalin-fixed and paraffin-embedded tissue: a comparison with immunohistochemical analysis.
Journal of hepatology 2000;32(3):406-11.
2000: Stier S; Totzke G; Grünewald E; Neuhaus T; Fronhoffs S; Sachinidis A; Vetter H; Schulze-Osthoff K; Ko Y
Identification of syntenin and other TNF-inducible genes in human umbilical arterial endothelial cells by suppression subtractive hybridization.
FEBS letters 2000;467(2-3):299-304.
2000: Ortiz-Pallardó M E; Zhou H; Fischer H P; Neuhaus T; Sachinidis A; Vetter H; Brüning T; Ko Y
Rapid analysis of alpha1-antitrypsin PiZ genotype by a real-time PCR approach.
Journal of molecular medicine (Berlin, Germany) 2000;78(4):212-6.
1999: Fronhoffs S; Mengden T; Oliveira J; Sachinidis A; Vetter H
Cholesterol enhances contractile responses in isolated small mesenteric arteries of normotensive and spontaneously hypertensive rats.
Journal of hypertension 1999;17(12 Pt 2):1941-7.
1999: Sachinidis A; Gouni-Berthold I; Seul C; Seewald S; Ko Y; Schmitz U; Vetter H
Early intracellular signalling pathway of ethanol in vascular smooth muscle cells.
British journal of pharmacology 1999;128(8):1761-71.
1999: Sachinidis A; Kettenhofen R; Seewald S; Gouni-Berthold I; Schmitz U; Seul C; Ko Y; Vetter H
Evidence that lipoproteins are carriers of bioactive factors.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(10):2412-21.
1999: Hoppe J; Schäfer R; Hoppe V; Sachinidis A
ATP and adenosine prevent via different pathways the activation of caspases in apoptotic AKR-2B fibroblasts.
Cell death and differentiation 1999;6(6):546-56.
1999: Ko Y; Totzke G; Gouni-Berthold I; Sachinidis A; Vetter H
Cytokine-inducible growth factor gene expression in human umbilical endothelial cells.
Molecular and cellular probes 1999;13(3):203-11.
1999: Seewald S; Schmitz U; Seul C; Ko Y; Sachinidis A; Vetter H
Lysophosphatidic acid stimulates protein kinase C isoforms alpha, beta, epsilon, and zeta in a pertussis toxin sensitive pathway in vascular smooth muscle cells.
American journal of hypertension 1999;12(5):532-7.
1999: Sachinidis A; Carniel M; Seewald S; Seul C; Gouni-Berthold I; Ko Y; Vetter H
Lipid-induced changes in vascular smooth muscle cell membrane fluidity are associated with DNA synthesis.
Cell proliferation 1999;32(2-3):101-5.
1999: Ahn H Y; Hadizadeh K R; Seul C; Yun Y P; Vetter H; Sachinidis A
Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172).
Molecular biology of the cell 1999;10(4):1093-104.
1998: Ko Y; Klinz M; Totzke G; Gouni-Berthold I; Sachinidis A; Vetter H
Limitations of the reverse transcription-polymerase chain reaction method for the detection of carcinoembryonic antigen-positive tumor cells in peripheral blood.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(9):2141-6.
1998: Kettenhofen R; Meyer zu Brickwedde M K; KO Y; Vetter H; Sachinidis A
Identification of a phosphodiesterase I/nucleotide pyrophosphatase-related gene mRNA in rat vascular smooth muscle cells by the differential display approach.
Journal of molecular biology 1998;279(2):323-9.
1998: Seewald S; Seul C; Kettenhofen R; Bokemeyer D; Ko Y; Vetter H; Sachinidis A
Role of mitogen-activated protein kinase in the angiotensin II-induced DNA synthesis in vascular smooth muscle cells.
Hypertension 1998;31(5):1151-6.
1998: Weber A A; Seul C; Harth V; Ko Y; Seewald S; Vetter H; Sachinidis A
Inhibition of glycosphingolipid synthesis by threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and the modulation of IL-1beta-stimulated expression of inducible nitric oxide synthase in rat aortic smooth muscle cells.
British journal of pharmacology 1998;123(5):906-10.
1997: Seewald S; Sachinidis A; Seul C; Kettenhofen R; Ko Y; Vetter H
The role of platelet-derived growth factor-BB-induced increase in cytosolic free Ca2+ in activation of mitogen-activated protein kinase and DNA synthesis in vascular smooth muscle cells.
Journal of hypertension 1997;15(12 Pt 2):1671-5.
1997: Seewald S; Nickenig G; Ko Y; Vetter H; Sachinidis A
Low density lipoprotein enhances the thrombin-induced growth of vascular smooth muscle cells.
Cardiovascular research 1997;36(1):92-100.
1997: Zeitler H; Ko Y; Zimmermann C; Nickenig G; Glänzer K; Walger P; Sachinidis A; Vetter H
Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction.
European journal of medical research 1997;2(9):389-94.
1997: Sachinidis A; Seewald S; Epping P; Seul C; Ko Y; Vetter H
The growth-promoting effect of low-density lipoprotein may Be mediated by a pertussis toxin-sensitive mitogen-activated protein kinase pathway.
Molecular pharmacology 1997;52(3):389-97.
1997: Kessler R; Leibhammer S; Laue O; Sachinidis A; Siffert W; Hols H; Vetter H; Düsing R
Acute saline infusion induces extracellular acidification and activation of the Na+/H+ exchanger in man.
European journal of clinical investigation 1997;27(7):558-65.
1997: Seewald S; Sachinidis A; Düsing R; Ko Y; Seul C; Epping P; Vetter H
Lysophosphatidic acid and intracellular signalling in vascular smooth muscle cells.
Atherosclerosis 1997;130(1-2):121-31.
1997: Nickenig G; Geisen G; Vetter H; Sachinidis A
Characterization of angiotensin receptors on human skin fibroblasts.
Journal of molecular medicine (Berlin, Germany) 1997;75(3):217-22.
1997: Ko Y; Glodny B; Stier S; Totzke G; Nickenig G; Düsing R; Sachinidis A; Vetter H
Angiotensin type-1 (AT1) receptor gene expression in primarily cultured human arterial umbilical endothelial cells.
Biochemical pharmacology 1997;53(3):417-21.
1997: Sachinidis A; Liu M; Weber A A; Seul C; Harth V; Seewald S; Ko Y; Vetter H
Cholesterol enhances platelet-derived growth factor-BB-induced [Ca2+]i and DNA synthesis in rat aortic smooth muscle cells.
Hypertension 1997;29(1 Pt 2):326-33.
1997: Nickenig G; Sachinidis A; Michaelsen F; Böhm M; Seewald S; Vetter H
Upregulation of vascular angiotensin II receptor gene expression by low-density lipoprotein in vascular smooth muscle cells.
Circulation 1997;95(2):473-8.
1997: Zeitler H; Ko Y; Glodny B; Totzke G; Appenheimer M; Sachinidis A; Vetter H
Cell-cycle arrest in G0/G1 phase of growth factor-induced endothelial cell proliferation by various calcium channel blockers.
Cancer detection and prevention 1997;21(4):332-9.
1996: Totzke G; Sachinidis A; Vetter H; Ko Y
Competitive reverse transcription/polymerase chain reaction for the quantification of p53 and mdm2 mRNA expression.
Molecular and cellular probes 1996;10(6):427-33.
1996: Sachinidis A; Seul C; Ko Y; Düsing R; Vetter H
Effect of the Na+/H+ antiport inhibitor Hoe 694 on the angiotensin II-induced vascular smooth muscle cell growth.
British journal of pharmacology 1996;119(5):787-96.
1996: Sachinidis A; Seul C; Seewald S; Ko Y; Vetter H
Activation of Na+/H+ exchanger is not involved in the PDGF-BB-induced DNA-synthesis in vascular smooth muscle cells.
Biochemical and biophysical research communications 1996;227(2):468-72.
1996: Sachinidis A; Kraus R; Seul C; Meyer zu Brickwedde M K; Schulte K; Ko Y; Hoppe J; Vetter H
Gangliosides GM1, GM2 and GM3 inhibit the platelet-derived growth factor-induced signalling transduction pathway in vascular smooth muscle cells by different mechanisms.
European journal of cell biology 1996;71(1):79-88.
1996: Weber A A; Neuhaus T; Seul C; Düsing R; Schrör K; Sachinidis A; Vetter H
Biotransformation of glyceryl trinitrate by blood platelets as compared to vascular smooth muscle cells.
European journal of pharmacology 1996;309(2):209-13.
1996: Sachinidis A; Schulte K B; Ko Y; Seul C; Meyer zu Brickwedde M K; Düsing R; Vetter H
Oligodeoxynucleotides directed to early growth response gene-1 mRNA inhibit DNA synthesis in the smooth muscle cell.
European journal of pharmacology 1996;309(1):95-105.
1996: Sachinidis A; el-Haschimi K; Ko Y; Seul C; Düsing R; Vetter H
CV-11974, the active metabolite of TCV-116 (Candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells.
Biochemical pharmacology 1996;52(1):123-6.
1996: Thömmes K B; Hoppe J; Vetter H; Sachinidis A
The synergistic effect of PDGF-AA and IGF-1 on VSMC proliferation might be explained by the differential activation of their intracellular signaling pathways.
Experimental cell research 1996;226(1):59-66.
1996: Sachinidis A; el-Haschimi K; Ko Y; Seul C; Epping P; Vetter H
Carbocyclic thromboxane A2 enhances the angiotensin II-induced DNA synthesis in smooth muscle cells.
European journal of pharmacology 1996;307(1):121-4.
1996: Nickenig G; Sachinidis A; Ko Y; Vetter H
Regulation of angiotensin AT1 receptor gene expression during cell growth of vascular smooth muscle cells.
European journal of pharmacology 1996;297(3):307-12.
1995: Ko Y; Totzke G; Seewald S; Schmitz U; Schiermeyer B; Meyer zu Brickwedde M K; Vetter H; Sachinidis A
Native low-density lipoprotein (LDL) induces the expression of the early growth response gene-1 in human umbilical arterial endothelial cells.
European journal of cell biology 1995;68(3):306-12.
1995: Sachinidis A; Flesch M; Ko Y; Schrör K; Böhm M; Düsing R; Vetter H
Thromboxane A2 and vascular smooth muscle cell proliferation.
Hypertension 1995;26(5):771-80.
1995: Ko Y; Totzke G; Schiermeyer B; Zeitler H; Schmitz U; Vetter H; Sachinidis A
Reverse transcriptase-polymerase chain reaction (RT-PCR): a sensitive method to examine basic fibroblast growth factor-induced expression of the early growth response gene-1 (egr-1) in human umbilical arterial endothelial cells.
Molecular and cellular probes 1995;9(4):215-22.
1995: Flesch M; Ko Y; Seul C; Düsing R; Feltkamp H; Vetter H; Sachinidis A
Effects of TCV-116 and CV-11974 on angiotensin II-induced responses in vascular smooth muscle cells.
European journal of pharmacology 1995;289(2):399-402.
1995: Hoffmann G; Ko Y; Sachinidis A; Göbel B O; Vetter H; Rosskopf D; Siffert W; Düsing R
Kinetics of Na+/H+ exchange in vascular smooth muscle cells from WKY and SHR: effects of phorbol ester.
The American journal of physiology 1995;268(1 Pt 1):C14-20.
1995: Zucker T P; Grosser T; Morinelli T; Halushka P V; Sachinidis A; Vetter H; Schrör K
Potentiation of PDGF-induced growth responses in coronary artery smooth muscle cells by thromboxane.
Agents and actions. Supplements 1995;45():53-8.
1994: Flesch M; Sachinidis A; Ko Y D; Kraft K; Vetter H
Plasma lipids and lipoproteins and essential hypertension.
The Clinical investigator 1994;72(12):944-50.
1994: Hoppe J; Hoppe V; Karenberg T A; Fenn A; Simm A; Sachinidis A
Differential activation by platelet-derived growth factor-BB of mitogen activated protein kinases in starved or nonstarved AKR-2B fibroblasts.
Journal of cellular physiology 1994;161(2):342-50.
1994: Karenberg T A; Fenn A; Sachinidis A; Hoppe J
The differential activation of phosphatidylinositol-3 kinase and mitogen-activated protein kinases by PDGF-AA and IGF-I might explain the synergistic effect of the two growth factors on the proliferation of AKR-2B fibroblasts.
Experimental cell research 1994;213(1):266-74.
1994: Ko Y D; Seewald S; Stiebler H; Sachinidis A; Vetter H
[Bone pain, polydipsia, polyuria]
Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis 1994;83(7):193-6.
1994: Nickenig G; Ko Y; Nettekoven W; Appenheimer M; Schiermeyer B; Vetter H; Sachinidis A
Oxymetazoline enhances epidermal- and platelet-derived growth factor-induced DNA synthesis.
Atherosclerosis 1994;105(1):71-7.
1993: Ko Y; Totzke G; Schulte K; Schiermeyer B; Meyer zu Brickwedde M K; Vetter H; Sachinidis A
Lipoprotein-induced expression of the sis oncogene in human arterial endothelial cells.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1993;11(5):S132-3.
1993: Sachinidis A; Ko Y; Schulte K B; Appenheimer M; Seul C; Meyer zu Brickwedde M K; Nickenig G; Vetter H
Effects of lipoproteins on the expression of the early growth response gene-1 and on DNA synthesis in rat vascular smooth muscle cells.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1993;11(5):S116-7.
1993: Ko Y; Totzke G; Graack G H; Heidgen F J; Meyer zu Brickwedde M K; Düsing R; Vetter H; Sachinidis A
Action of dihydropyridine calcium antagonists on early growth response gene expression and cell growth in vascular smooth muscle cells.
Journal of hypertension 1993;11(11):1171-8.
1993: Ko Y; Stiebler H; Nickenig G; Wieczorek A J; Vetter H; Sachinidis A
Synergistic action of angiotensin II, insulin-like growth factor-I, and transforming growth factor-beta on platelet-derived growth factor-BB, basic fibroblastic growth factor, and epidermal growth factor-induced DNA synthesis in vascular smooth muscle cells.
American journal of hypertension 1993;6(6 Pt 1):496-9.
1993: Ko Y; Sachinidis A; Wieczorek A J; Appenheimer M; Düsing R; Vetter H
Insulin enhances angiotensin II induced DNA synthesis in vascular smooth muscle cells of the rat.
The Clinical investigator 1993;71(5):379-82.
1993: Weisser B; Locher R; de Graaf J; Moser R; Sachinidis A; Vetter W
Low density lipoprotein subfractions increase thromboxane formation in endothelial cells.
Biochemical and biophysical research communications 1993;192(3):1245-50.
1993: Sachinidis A; Ko Y; Wieczorek A; Weisser B; Locher R; Vetter W; Vetter H
Lipoproteins induce expression of the early growth response gene-1 in vascular smooth muscle cells from rat.
Biochemical and biophysical research communications 1993;192(2):794-9.
1993: Ko Y; Nettekoven W; Christian R; Wieczorek A J; Düsing R; Vetter H; Sachinidis A
Long-term insulin treatment of vascular smooth muscle cells from rat aorta attenuates the synergistic effect of insulin on angiotensin II- and epidermal growth factor-induced DNA synthesis.
Clinical science (London, England : 1979) 1993;84(4):435-40.
1993: Ko Y; Häring R; Stiebler H; Wieczorek A J; Vetter H; Sachinidis A
High-density lipoprotein reduces epidermal growth factor-induced DNA synthesis in vascular smooth muscle cells.
Atherosclerosis 1993;99(2):253-9.
1993: Sachinidis A; Schulte K; Ko Y; Meyer zu Brickwedde M K; Hoppe V; Hoppe J; Vetter H
The induction of early response genes in rat smooth muscle cells by PDGF-AA is not sufficient to stimulate DNA-synthesis.
FEBS letters 1993;319(3):221-4.
1993: Sachinidis A; Ko Y; Weisser P; Meyer zu Brickwedde M K; Düsing R; Christian R; Wieczorek A J; Vetter H
EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells.
Journal of hypertension 1993;11(2):155-62.
1992: Sachinidis A; Weisser P; Ko Y; Schulte K; Meyer zu Brickwedde K; Neyses L; Vetter H
Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.
FEBS letters 1992;313(2):109-12.
1992: Ko Y; Görg A; Appenheimer M; Wieczorek A J; Düsing R; Vetter H; Sachinidis A
Losartan inhibits the angiotensin II-induced stimulation of the phosphoinositide signalling system in vascular smooth muscle cells.
European journal of pharmacology 1992;227(2):215-9.
1992: Sachinidis A; Ko Y; Nettekoven W; Wieczorek A J; Düsing R; Vetter H
The effect of angiotensin II on DNA synthesis varies considerably in vascular smooth muscle cells from different Wistar-Kyoto rats.
Journal of hypertension 1992;10(10):1159-64.
1992: Ko Y D; Sachinidis A; Graack G H; Appenheimer M; Wieczorek A J; Düsing R; Vetter H
Inhibition of angiotensin II and platelet-derived growth factor-induced vascular smooth muscle cell proliferation by calcium entry blockers.
The Clinical investigator 1992;70(2):113-7.
1992: Sachinidis A; Ko Y; Graack G K; Wieczorek A J; Vetter H
Action of metoprolol, enalapril, diltiazem, verapamil, and nifedipine on cell growth of vascular smooth muscle cells.
Journal of cardiovascular pharmacology 1992;19 Suppl 2():S60-2.
1992: Weisser B; Locher R; Mengden T; Sachinidis A; Vetter W
Oxidized low-density lipoproteins in atherogenesis: possible mechanisms of action.
Journal of cardiovascular pharmacology 1992;19 Suppl 2():S4-7.
1991: Sachinidis A; Görg A; Ko Y; Wieczorek A J; Düsing R; Vetter H
Effect of the angiotensin II receptor antagonist MK 954 on the angiotensin II-induced increase in free cytosolic Ca2+ and growth in vascular smooth muscle cells.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1991;9(6):S226-7.
1991: Sachinidis A; Ko Y; Wieczorek A J; Locher R; Appenheimer M; Vetter H; Vetter W
The maximal stimulatory effect of low-density lipoprotein on the cytosolic free calcium ion depends on the presence of its lipid and protein component.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1991;9(6):S186-7.
1991: Weisser B; Locher R; Mengden T; Sachinidis A; Vetter W
Oxidation of low-density lipoprotein increases vasoconstriction in vitro.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1991;9(6):S172-3.
1991: Locher R; Sachinidis A; Brunner C; Vetter W
Intracellular free calcium concentration and thromboxane A2 formation of vascular smooth muscle cells are influenced by fish oil and n-3 eicosapentaenoic acid.
Scandinavian journal of clinical and laboratory investigation 1991;51(6):541-7.
1990: Sachinidis A; Locher R; Hoppe J; Vetter W
The platelet-derived growth factor isomers, PDGF-AA, PDGF-AB and PDGF-BB, induce contraction of vascular smooth muscle cells by different intracellular mechanisms.
FEBS letters 1990;275(1-2):95-8.
1990: Sachinidis A; Mengden T; Locher R; Brunner C; Vetter W
Novel cellular activities for low density lipoprotein in vascular smooth muscle cells.
Hypertension 1990;15(6 Pt 2):704-11.
1990: Sachinidis A; Locher R; Vetter W; Tatje D; Hoppe J
Different effects of platelet-derived growth factor isoforms on rat vascular smooth muscle cells.
The Journal of biological chemistry 1990;265(18):10238-43.
1990: Locher R; Sachinidis A; Steiner A; Vetter W
Attenuation of the low-density-lipoprotein-activated phosphoinositide signalling system by calcium blockers in human lymphocytes.
Clinical science (London, England : 1979) 1990;78(5):509-14.
1990: Sachinidis A; Locher R; Mengden T; Vetter W
Low-density lipoprotein elevates intracellular calcium and pH in vascular smooth muscle cells and fibroblasts without mediation of LDL receptor.
Biochemical and biophysical research communications 1990;167(1):353-9.
1989: Sachinidis A; Locher R; Steiner A; Mengden T; Vetter W
Effect of low-density lipoprotein on intracellular calcium, intracellular pH and DNA synthesis in cultured vascular smooth muscle cells.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1989;7(6):S116-7.
1989: Steiner A; Locher R; Sachinidis A; Vetter W
Cortisol-stimulated phosphoinositide metabolism in vascular smooth muscle cells: a role for glucocorticoids in blood pressure control?
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1989;7(6):S140-1.
1989: Sachinidis A; Locher R; Mengden T; Steiner A; Vetter W
Vasoconstriction: a novel activity for low density lipoprotein.
Biochemical and biophysical research communications 1989;163(1):315-20.
1989: Locher R; Sachinidis A; Steiner A; Vogt E; Vetter W
Fish oil affects phosphoinositide turnover and thromboxane A metabolism in cultured vascular muscle cells.
Biochimica et biophysica acta 1989;1012(3):279-83.
1989: Block L H; Emmons L R; Vogt E; Sachinidis A; Vetter W; Hoppe J
Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2388-92.

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