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dennis danley

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David Cunningham; Wen Lin; Lise R Hoth; dennis danley; Roger B Ruggeri; Kieran F Geoghegan; Boris A Chrunyk; James G Boyd
Biophysical and biochemical approach to locating an inhibitor binding site on cholesteryl ester transfer protein.
Kevin D Freeman-Cook; Lawrence A Reiter; Mark C Noe; Amy S Antipas; dennis danley; Kaushik Datta; James T Downs; Shane Eisenbeis; James D Eskra; David J Garmene; Elaine M Greer; Richard J Griffiths; Roberto Guzman; Joel R Hardink; Fouad Janat; Christopher S Jones; Gary J Martinelli; Peter G Mitchell; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Jayvardhan Pandit; Usa D Reilly; Donald Robertson; Marcie L Vaughn-Bowser; Lilli A Wolf-Gouviea; Sue A Yocum
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Stephen W Wright; Mark J Ammirati; Kim M Andrews; Anne M Brodeur; dennis danley; Shawn D Doran; Jay S Lillquist; Shenping Liu; Lester D McClure; R Kirk McPherson; Thanh V Olson; Stephen J Orena; Janice C Parker; Benjamin N Rocke; Walter Soeller; Carolyn B Soglia; Judith L Treadway; Maria A Vanvolkenburg; Zhengrong Zhao; Eric D Cox
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.

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All Publications

2008: David Cunningham; Wen Lin; Lise R Hoth; dennis danley; Roger B Ruggeri; Kieran F Geoghegan; Boris A Chrunyk; James G Boyd
Biophysical and biochemical approach to locating an inhibitor binding site on cholesteryl ester transfer protein.
Bioconjugate chemistry 2008;19(8):1604-13.
2007: Kevin D Freeman-Cook; Lawrence A Reiter; Mark C Noe; Amy S Antipas; dennis danley; Kaushik Datta; James T Downs; Shane Eisenbeis; James D Eskra; David J Garmene; Elaine M Greer; Richard J Griffiths; Roberto Guzman; Joel R Hardink; Fouad Janat; Christopher S Jones; Gary J Martinelli; Peter G Mitchell; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Jayvardhan Pandit; Usa D Reilly; Donald Robertson; Marcie L Vaughn-Bowser; Lilli A Wolf-Gouviea; Sue A Yocum
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Bioorganic & medicinal chemistry letters 2007;17(23):6529-34.
2007: Stephen W Wright; Mark J Ammirati; Kim M Andrews; Anne M Brodeur; dennis danley; Shawn D Doran; Jay S Lillquist; Shenping Liu; Lester D McClure; R Kirk McPherson; Thanh V Olson; Stephen J Orena; Janice C Parker; Benjamin N Rocke; Walter Soeller; Carolyn B Soglia; Judith L Treadway; Maria A Vanvolkenburg; Zhengrong Zhao; Eric D Cox
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
Bioorganic & medicinal chemistry letters 2007;17(20):5638-42.
2007: Felix F Vajdos; Lise R Hoth; Kieran F Geoghegan; Samuel P Simons; Peter K LeMotte; dennis danley; Mark J Ammirati; Jayvardhan Pandit
The 2.0 A crystal structure of the ERalpha ligand-binding domain complexed with lasofoxifene.
Protein science : a publication of the Protein Society 2007;16(5):897-905.
2007: David Cunningham; dennis danley; Kieran F Geoghegan; Matthew C Griffor; Julie L Hawkins; Timothy A Subashi; Alison H Varghese; Mark J Ammirati; Jeffrey S Culp; Lise R Hoth; Mahmoud N Mansour; Katherine McGrath; Andrew P Seddon; Shirish Shenolikar; Kim J Stutzman-Engwall; Laurie C Warren; Donghui Xia; Xiayang Qiu
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.
Nature structural & molecular biology 2007;14(5):413-9.
2007: Xiayang Qiu; Anil Mistry; Mark J Ammirati; Boris A Chrunyk; Ronald W Clark; Yang Cong; Jeffrey S Culp; dennis danley; Thomas B Freeman; Kieran F Geoghegan; Matthew C Griffor; Steven J Hawrylik; Cheryl M Hayward; Preston Hensley; Lise R Hoth; George A Karam; Maruja E Lira; David B Lloyd; Katherine McGrath; Kim J Stutzman-Engwall; Ann K Subashi; Timothy A Subashi; John F Thompson; Ing-Kae Wang; Honglei Zhao; Andrew P Seddon
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.
Nature structural & molecular biology 2007;14(2):106-13.
2006: Seungil Han; Michael D Forman; Pat Loulakis; Michele H Rosner; Zhi Xie; Hong Wang; dennis danley; Wei Yuan; John Schafer; Zuoyu Xu
Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Staphyloccocus aureus: structural basis for NaAD interaction in functional dimer.
Journal of molecular biology 2006;360(4):814-25.
2006: Stephen W Wright; Mark J Ammirati; Kim M Andrews; Anne M Brodeur; dennis danley; Shawn D Doran; Jay S Lillquist; Lester D McClure; R Kirk McPherson; Stephen J Orena; Janice C Parker; Jana Polivkova; Xiayang Qiu; Walter Soeller; Carolyn B Soglia; Judith L Treadway; Maria A Vanvolkenburg; Hong Wang; Donald C Wilder; Thanh V Olson
cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.
Journal of medicinal chemistry 2006;49(11):3068-76.
2006: dennis danley
Crystallization to obtain protein-ligand complexes for structure-aided drug design.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 6):569-75.
2005: Kim F McClure; Yuriy A Abramov; Ellen R Laird; John T Barberia; Weiling Cai; Thomas J Carty; Santo R Cortina; dennis danley; Alan J Dipesa; Kathleen M Donahue; Mark A Dombroski; Nancy C Elliott; Christopher A Gabel; Seungil Han; THOMAS HYNES; Peter K LeMotte; Mahmoud N Mansour; Eric S Marr; Michael A Letavic; Jayvardhan Pandit; David B Ripin; Francis J Sweeney; Douglas Tan; Yong Tao
Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase.
Journal of medicinal chemistry 2005;48(18):5728-37.
2005: Julian A Blagg; Mark C Noe; Lilli A Wolf-Gouveia; Lawrence A Reiter; Ellen R Laird; Shang-Poa P Chang; dennis danley; James T Downs; Nancy C Elliott; James D Eskra; Richard J Griffiths; Joel R Hardink; Amber I Haugeto; Christopher S Jones; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Ralph P Robinson; Chakrapani Subramanyam; Marcie L Vaughn-Bowser; Sue A Yocum
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.
Bioorganic & medicinal chemistry letters 2005;15(7):1807-10.
2003: Stephen W Wright; Anthony A Carlo; dennis danley; David L Hageman; George A Karam; Mahmoud N Mansour; Lester D McClure; Jayvardhan Pandit; Gayle K Schulte; Judith L Treadway; Ing-Kae Wang; Paul H Bauer
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site.
Bioorganic & medicinal chemistry letters 2003;13(12):2055-8.
2003: Thomas A Pauly; Traian Sulea; Mark J Ammirati; J Sivaraman; dennis danley; Matthew C Griffor; Ajith V Kamath; Ing-Kae Wang; Ellen R Laird; Andrew P Seddon; Robert Ménard; Miroslaw Cygler; Virginia L Rath
Specificity determinants of human cathepsin s revealed by crystal structures of complexes.
Biochemistry 2003;42(11):3203-13.
2003: Robert L Dow; Steven R Schneider; Ernest S Paight; Richard F Hank; Phoebe Chiang; Peter Cornelius; Eunsun Lee; William P Newsome; Andrew G Swick; Josephine Spitzer; Diane M Hargrove; Terrell A Patterson; Jayvardhan Pandit; Boris A Chrunyk; Peter K LeMotte; dennis danley; Michele H Rosner; Mark J Ammirati; Samuel P Simons; Gayle K Schulte; Barbara Tate; Paul DaSilva-Jardine
Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics.
Bioorganic & medicinal chemistry letters 2003;13(3):379-82.
2002: Stephen W Wright; Anthony A Carlo; Maynard D Carty; dennis danley; David L Hageman; George A Karam; Carolyn B Levy; Mahmoud N Mansour; Alan M Mathiowetz; Lester D McClure; Nestor B Nestor; R Kirk McPherson; Jayvardhan Pandit; Leslie R Pustilnik; Gayle K Schulte; Walter Soeller; Judith L Treadway; Ing-Kae Wang; Paul H Bauer
Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography.
Journal of medicinal chemistry 2002;45(18):3865-77.
2002: Jennifer L Ekstrom; Thomas A Pauly; Maynard D Carty; Walter Soeller; Jeffrey S Culp; dennis danley; Dennis J Hoover; Judith L Treadway; E Michael Gibbs; Robert J Fletterick; Yasmina S N Day; David G Myszka; Virginia L Rath
Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chemistry & biology 2002;9(8):915-24.
2002: Michael A Letavic; Matt Z Axt; John T Barberia; Thomas J Carty; dennis danley; Kieran F Geoghegan; Nadia S Halim; Lise R Hoth; Ajith V Kamath; Ellen R Laird; Lori L Lopresti-Morrow; Kim F McClure; Peter G Mitchell; Vijayalakshmi Natarajan; Mark C Noe; Jayvardhan Pandit; Lisa M Reeves; Gayle K Schulte; Sheri L Snow; Francis J Sweeney; Douglas H Tan; Chul H Yu
Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(10):1387-90.
2001: Frank S Kaczmarek; RP Zaniewski; Thomas D Gootz; dennis danley; Mahmoud N Mansour; Matthew C Griffor; Ajith V Kamath; Melissa Cronan; J Mueller; D Sun; PK Martin; B Benton; L McDowell; D Biek; Molly B Schmid
Cloning and functional characterization of an NAD(+)-dependent DNA ligase from Staphylococcus aureus.
Journal of bacteriology 2001;183(10):3016-24.
2000: Jayvardhan Pandit; dennis danley; Gayle K Schulte; S Mazzalupo; Thomas A Pauly; C M Hayward; E S Hamanaka; J F Thompson; H J Harwood
Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
The Journal of biological chemistry 2000;275(39):30610-7.
2000: Virginia L Rath; Mark J Ammirati; dennis danley; Jennifer L Ekstrom; E Michael Gibbs; THOMAS HYNES; Alan M Mathiowetz; R Kirk McPherson; Thanh V Olson; Judith L Treadway; Dennis J Hoover
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.
Chemistry & biology 2000;7(9):677-82.
2000: Philip G Board; Marjorie Coggan; G Chelvanayagam; Simon Easteal; Lars S Jermiin; Gayle K Schulte; dennis danley; Lise R Hoth; Matthew C Griffor; A V Kamath; Michele H Rosner; Boris A Chrunyk; D E Perregaux; Christopher A Gabel; Kieran F Geoghegan; Jayvardhan Pandit
Identification, characterization, and crystal structure of the Omega class glutathione transferases.
The Journal of biological chemistry 2000;275(32):24798-806.
2000: dennis danley; M E Haggan; David Cunningham; K F Fennell; Thomas A Pauly; Peter K LeMotte
A crystallizable form of RIIbeta regulatory domain obtained by limited proteolysis.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 8):1038-41.
2000: Virginia L Rath; Mark J Ammirati; Peter K LeMotte; K F Fennell; Mahmoud N Mansour; dennis danley; THOMAS HYNES; Gayle K Schulte; D J Wasilko; Jayvardhan Pandit
Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core.
Molecular cell 2000;6(1):139-48.
1999: Lawrence A Reiter; J P Rizzi; Jayvardhan Pandit; M J Lasut; S M McGahee; V D Parikh; James F Blake; dennis danley; Ellen R Laird; Arturo Lopez-Anaya; Lori L Lopresti-Morrow; Mahmoud N Mansour; Gary J Martinelli; Peter G Mitchell; B S Owens; Thomas A Pauly; Lisa M Reeves; Gayle K Schulte; Sue A Yocum
Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket.
Bioorganic & medicinal chemistry letters 1999;9(2):127-32.
1998: William Martin; Dennis J Hoover; Sandra J Armento; Ingrid A Stock; R Kirk McPherson; dennis danley; R W Stevenson; E J Barrett; Judith L Treadway
Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1776-81.
1998: John F Thompson; dennis danley; S Mazzalupo; Patrice M Milos; Maruja E Lira; H J Harwood
Truncation of human squalene synthase yields active, crystallizable protein.
Archives of biochemistry and biophysics 1998;350(2):283-90.
1997: Tsung-Hsien Chuang; Klaus M Hahn; J D Lee; dennis danley; Gary M Bokoch
The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes.
Molecular biology of the cell 1997;8(9):1687-98.
1996: dennis danley; Tsung-Hsien Chuang; Gary M Bokoch
Defective Rho GTPase regulation by IL-1 beta-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):500-3.
1996: M Mansour; M Karmilowicz; S J Hawrylik; B Nalcerio; J Angilly; Maryrose Conklyn; C M Lilly; J M Drazen; S E Lee; D D Auperin; J R De Wet; Victoria L Cohan; Henry J Showell; dennis danley
Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells.
The American journal of physiology 1996;270(6 Pt 1):L1002-7.
1996: S Na; Tsung-Hsien Chuang; A Cunningham; T G Turi; J H Hanke; Gary M Bokoch; dennis danley
D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis.
The Journal of biological chemistry 1996;271(19):11209-13.
1992: J Mottonen; A Strand; J Symersky; R M Sweet; dennis danley; Kieran F Geoghegan; Robert D Gerard; Elizabeth J Goldsmith
Structural basis of latency in plasminogen activator inhibitor-1.
Nature 1992;355(6357):270-3.
1991: H E Grenett; dennis danley; C A Strick; L C James; I G Otterness; N Fuentes; J E Nesbitt; Gerald M Fuller
Isolation and characterization of biologically active murine interleukin-6 produced in Escherichia coli.
Gene 1991;101(2):267-71.
1991: dennis danley; C A Strick; L C James; Anthony Lanzetti; I G Otterness; H E Grenett; G M Fuller
Identification and characterization of a C-terminally extended form of recombinant murine IL-6.
FEBS letters 1991;283(1):135-9.
1991: Elizabeth J Goldsmith; C Sheng-Cheng; dennis danley; Robert D Gerard; Kieran F Geoghegan; J Mottonen; A Strand
Preliminary X-ray analysis of crystals of plasminogen activator inhibitor-1.
Proteins 1991;9(3):225-7.
1991: Kieran F Geoghegan; Anthony Lanzetti; M J Ammirati; dennis danley; B A O'Connor; P M Hobart
Simple procedure for recovery of crystallizable human recombinant renin from mammalian cell-conditioned medium.
Advances in experimental medicine and biology 1991;306():379-81.
1990: Tom L Blundell; R Lapatto; A F Wilderspin; A M Hemmings; P M Hobart; dennis danley; P J Whittle
The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS.
Trends in biochemical sciences 1990;15(11):425-30.
1990: K F Geohegan; R W Spencer; dennis danley; L G Contillo; glenn andrews
Fluorescence-based continuous assay for the aspartyl protease of human immunodeficiency virus-1.
FEBS letters 1990;262(1):119-22.
1990: A E Franke; dennis danley; F S Kaczmarek; S J Hawrylik; Robert D Gerard; S E Lee; Kieran F Geoghegan
Expression of human plasminogen activator inhibitor type-1 (PAI-1) in Escherichia coli as a soluble protein comprised of active and latent forms. Isolation and crystallization of latent PAI-1.
Biochimica et biophysica acta 1990;1037(1):16-23.
1989: dennis danley; Kieran F Geoghegan; K G Scheld; S E Lee; J R Merson; S J Hawrylik; G A Rickett; M J Ammirati; P M Hobart
Crystallizable HIV-1 protease derived from expression of the viral pol gene in Escherichia coli.
Biochemical and biophysical research communications 1989;165(3):1043-50.
1989: R Lapatto; Tom L Blundell; A Hemmings; J Overington; A Wilderspin; S Wood; J R Merson; P J Whittle; dennis danley; Kieran F Geoghegan
X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes.
Nature 1989;342(6247):299-302.
1988: dennis danley; Kieran F Geoghegan
Structure and mechanism of formation of recombinant-derived chymosin C.
The Journal of biological chemistry 1988;263(20):9785-9.
1984: T J Moehring; dennis danley; J M Moehring
In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin.
Molecular and cellular biology 1984;4(4):642-50.
1980: J M Moehring; T J Moehring; dennis danley
Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cells.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(2):1010-4.
1979: T J Moehring; dennis danley; J M Moehring
Codominant translational mutants of Chinese hamster ovary cells selected with diphtheria toxin.
Somatic cell genetics 1979;5(4):469-80.
1977: dennis danley; M Drexler; J L Botsford
Differential binding of cyclic adenosine 3' ,5'-monophosphate to the cyclic adenosine 3' ,5'-monophosphate receptor protein in Escherichia coli.
Journal of bacteriology 1977;130(1):563-5.