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Guojun Bu

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Endocytosis

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Alzheimer's Disease

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Publications

TOP 3
Philip B Verghese; Yinong Wang; Hong Jiang; Aarti Shah; Guojun Bu; Joseph M Castellano; Carl Frieden; Kanchan Garai; David M Holtzman
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.
Leon M Tai; Linda J Van Eldik; Harry V Vinters; Katherine L Youmans; Chunjiang Yu; Carol A Miller; Wayne W Poon; Stephen K Roeske; Tina Bilousova; Guojun Bu; Lindsey B Cornwell; Steven Estus; David Fardo; Karen Hoppens Gylys; Lisa M Jungbauer; Mary Jo Ladu
Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.
Katherine L Youmans; Chunjiang Yu; Evelyn Nwabuisi-Heath; G. William Rebeck; Leon M Tai; Edwin J Weeber; Guojun Bu; William A Eimer; Steven Estus; Ming Gan; Lisa M Jungbauer; Takahisa Kanekiyo; Jungsu Kim; Mary Jo Ladu
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

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All Publications

2013: Philip B Verghese; Yinong Wang; Hong Jiang; Aarti Shah; Guojun Bu; Joseph M Castellano; Carl Frieden; Kanchan Garai; David M Holtzman
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):E1807-16.
2013: Leon M Tai; Linda J Van Eldik; Harry V Vinters; Katherine L Youmans; Chunjiang Yu; Carol A Miller; Wayne W Poon; Stephen K Roeske; Tina Bilousova; Guojun Bu; Lindsey B Cornwell; Steven Estus; David Fardo; Karen Hoppens Gylys; Lisa M Jungbauer; Mary Jo Ladu
Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.
The Journal of biological chemistry 2013;288(8):5914-26.
2012: Katherine L Youmans; Chunjiang Yu; Evelyn Nwabuisi-Heath; G. William Rebeck; Leon M Tai; Edwin J Weeber; Guojun Bu; William A Eimer; Steven Estus; Ming Gan; Lisa M Jungbauer; Takahisa Kanekiyo; Jungsu Kim; Mary Jo Ladu
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.
The Journal of biological chemistry 2012;287(50):41774-86.
2012: David M Holtzman; Joachim Herz; Guojun Bu
Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease.
Cold Spring Harbor perspectives in medicine 2012;2(3):a006312.
2012: Katherine L Youmans; Chunjiang Yu; Lester Binder; Guojun Bu; William A Eimer; Yifan Fu; Dean M Hartley; Takahisa Kanekiyo; Arlene M Manelli; Sara-Claude Michon; Evelyn Nwabuisi-Heath; Sean Riordan; W Blaine Stine; Leon M Tai; Mary Jo Ladu
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.
Molecular neurodegeneration 2012;7():8.
2011: Micha M M Wilhelmus; Annemieke J M Rozemuller; Elise S van Haastert; John G J M Bol; Guojun Bu; Benjamin Drukarch; Jeroen J M Hoozemans
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.
The American journal of pathology 2011;179(5):2152-6.
2011: Jianglei Chen; Chia-Chen Liu; QianQian Li; Christian Nowak; Guojun Bu; Jianjun Wang
Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.
Structure (London, England : 1993) 2011;19(3):313-23.
2011: Qiang Liu; Juan Zhang; Celina Zerbinatti; Yan Zhan; Benedict J Kolber; Joachim Herz; Louis J Muglia; Guojun Bu
Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.
PLoS biology 2011;9(1):e1000575.
2010: Qiang Liu; Justin Trotter; Juan Zhang; Melinda M Peters; Hua Cheng; Jianxin Bao; Xianlin Han; Edwin J Weeber; Guojun Bu
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(50):17068-78.
2010: Jianglei Chen; QianQian Li; Chia-Chen Liu; Bei Zhou; Guojun Bu; Pei Zhou; Jianjun Wang
NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6.
Journal of biomolecular NMR 2010;47(4):283-8.
2010: Wenyan Lu; Chia-Chen Liu; Jaideep V Thottassery; Guojun Bu; Yonghe Li
Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.
Biochemistry 2010;49(22):4635-43.
2010: Chia-Chen Liu; Julie Prior; David Piwnica-Worms; Guojun Bu
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):5136-41.
2010: Junran Zhang; Y Li; Q Liu; Wenyan Lu; Guojun Bu
Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.
Oncogene 2010;29(4):539-49.
2010: Angela Jen; Celia J Parkyn; Roy Mootoosamy; Melanie J Ford; Alice Warley; Qiang Liu; Guojun Bu; Ilia Baskakov; Søren Moestrup; Lindsay McGuinness; Nigel Emptage; Roger J Morris
Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4.
Journal of cell science 2010;123(Pt 2):246-55.
2010: Rodrigo A. Fuentealba; Qiang Liu; Juan Zhang; Takahisa Kanekiyo; Xiaoyan Hu; Jin-Moo Lee; Mary Jo Ladu; Guojun Bu
Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking.
PloS one 2010;5(7):e11884.
2010: Yonghe Li; Wenyan Lu; Taj D King; Chia-Chen Liu; Gautam N Bijur; Guojun Bu
Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation.
PloS one 2010;5(6):e11014.
2009: Rodrigo A. Fuentealba; Qiang Liu; Takahisa Kanekiyo; Juan Zhang; Guojun Bu
Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.
The Journal of biological chemistry 2009;284(49):34045-53.
2009: Xiaoyan Hu; Scott L Crick; Guojun Bu; Carl Frieden; Rohit V Pappu; Jin-Moo Lee
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20324-9.
2009: Heesang Song; Guojun Bu
MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1.
Biochemical and biophysical research communications 2009;388(2):400-5.
2009: Hyang-Sook Hoe; kea joo lee; Rosalind S E Carney; Jiyeon Lee; Alexandra Markova; Ji-Yun Lee; Brian Howell; Bradley T Hyman; Daniel T S Pak; Guojun Bu; G. William Rebeck
Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(23):7459-73.
2009: Chia-Chen Liu; Chelsea Pearson; Guojun Bu
Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains.
The Journal of biological chemistry 2009;284(22):15299-307.
2009: David T Woodley; Jianhua Fan; Chieh-Fang Cheng; Yong Li; Mei Chen; Guojun Bu; Wei Li
Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration.
Journal of cell science 2009;122(Pt 10):1495-8.
2009: Guojun Bu
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy.
Nature reviews. Neuroscience 2009;10(5):333-44.
2009: María-Paz Marzolo; Guojun Bu
Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease.
Seminars in cell & developmental biology 2009;20(2):191-200.
2009: Shuji Hayashi; Masaki Yamamoto; Katsuhiro Tachibana; Yushi Ueno; Guojun Bu; Takeo Fukushima
Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death.
Anticancer research 2009;29(3):897-905.
2009: Heesang Song; Yonghe Li; Jiyeon Lee; Alan L Schwartz; Guojun Bu
Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9.
Cancer research 2009;69(3):879-86.
2009: Yunwu Zhang; Lisa Owens; Guojun Bu
Meeting report: 2009 international conference on molecular neurodegeneration May 18-20, 2009, Xiamen, China.
Molecular neurodegeneration 2009;4():43.
2009: Qiang Liu; Juan Zhang; Hien Tran; Marcel M Verbeek; Karina Reiss; Steven Estus; Guojun Bu
LRP1 shedding in human brain: roles of ADAM10 and ADAM17.
Molecular neurodegeneration 2009;4():17.
2009: Maribel Donoso; Jorge Cancino; Jiyeon Lee; Peter van Kerkhof; Claudio Retamal; Guojun Bu; Alfonso Gonzalez; Alfredo Cáceres; María-Paz Marzolo
Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways.
Molecular biology of the cell 2009;20(1):481-97.
2008: K Yamada; Tadafumi Hashimoto; Chiori Yabuki; Yusuke Nagae; Masanori Tachikawa; Dudley K Strickland; Qiang Liu; Guojun Bu; Jacob Basak; David M Holtzman; Sumio Ohtsuki; Tetsuya Terasaki; Takeshi Iwatsubo
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells.
The Journal of biological chemistry 2008;283(50):34554-62.
2008: Balraj Doray; Jane M Knisely; Lukas Wartman; Guojun Bu; Stuart Kornfeld
Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2.
Traffic (Copenhagen, Denmark) 2008;9(9):1551-62.
2008: Guojun Bu; Wenyan Lu; Chia-Chen Liu; Katri Selander; Toshiyuki Yoneda; Christopher L Hall; Evan T Keller; Yonghe Li
Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases.
International journal of cancer. Journal international du cancer 2008;123(5):1034-42.
2008: Jiyeon Lee; Claudio Retamal; Loreto Cuitiño; Amy Caruano-Yzermans; Jung-Eun Shin; Peter van Kerkhof; Maria-Paz Marzolo; Guojun Bu
Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.
The Journal of biological chemistry 2008;283(17):11501-8.
2008: John R Cirrito; Jae-Eun Kang; Jiyeon Lee; Floy R Stewart; Deborah K Verges; Luz M Silverio; Guojun Bu; Steven Mennerick; David M Holtzman
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo.
Neuron 2008;58(1):42-51.
2008: Celia J Parkyn; Esmeralda G M Vermeulen; Roy Mootoosamy; Claire Sunyach; Christian Jacobsen; Claus Oxvig; Søren Moestrup; Qiang Liu; Guojun Bu; Angela Jen; Roger J Morris
LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein.
Journal of cell science 2008;121(Pt 6):773-83.
2008: Kebin Hu; Ling Lin; Xiaoyue Tan; Junwei Yang; Guojun Bu; Wendy M Mars; Youhua Liu
tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis.
Journal of the American Society of Nephrology : JASN 2008;19(3):503-14.
2008: Jane M Knisely; Jiyeon Lee; Guojun Bu
Measurement of receptor endocytosis and recycling.
Methods in molecular biology (Clifton, N.J.) 2008;457():319-32.
2007: Micha M M Wilhelmus; Irene Otte-Höller; Jos J J van Triel; Robert Veerhuis; Marion L C Maat-Schieman; Guojun Bu; Robert M W de Waal; Marcel M Verbeek
Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells.
The American journal of pathology 2007;171(6):1989-99.
2007: Sen Chen; Guojun Bu; Yoshifumi Takei; Kazuma Sakamoto; Shinya Ikematsu; Takashi Muramatsu; Kenji Kadomatsu
Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells.
Journal of cell science 2007;120(Pt 22):4009-15.
2007: Qiang Liu; Celina V Zerbinatti; Juan Zhang; Hyang-Sook Hoe; Baiping Wang; Sarah L Cole; Joachim Herz; Louis J Muglia; Guojun Bu
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.
Neuron 2007;56(1):66-78.
2007: Jane M Knisely; Yonghe Li; Janice M Griffith; Hans J Geuze; Alan L Schwartz; Guojun Bu
Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation.
Experimental cell research 2007;313(15):3298-307.
2007: María Isabel Yuseff; Pamela Farfan; Guojun Bu; María-Paz Marzolo
A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression.
Traffic (Copenhagen, Denmark) 2007;8(9):1215-30.
2007: Jianglei Chen; Guojun Bu; Jianjun Wang
A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155).
Biomolecular NMR assignments 2007;1(1):3-5.
2007: Balraj Doray; Intaek Lee; Jane Knisely; Guojun Bu; Stuart Kornfeld
The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site.
Molecular biology of the cell 2007;18(5):1887-96.
2007: Rodrigo A. Fuentealba; María Inés Barría; Jiyeon Lee; Judy A Cam; Claudia Araya; Claudia A Escudero; Nibaldo C Inestrosa; Francisca C Bronfman; Guojun Bu; María-Paz Marzolo
ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.
Molecular neurodegeneration 2007;2():14.
2006: Celina V Zerbinatti; Suzanne E Wahrle; Hyungjin Kim; Judy A Cam; Kelly Bales; Steven M Paul; David M Holtzman; Guojun Bu
Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice.
The Journal of biological chemistry 2006;281(47):36180-6.
2006: Guojun Bu; Judy A Cam; Celina V Zerbinatti
LRP in amyloid-beta production and metabolism.
Annals of the New York Academy of Sciences 2006;1086():35-53.
2006: Yonghe Li; Wenyan Lu; Xi He; Guojun Bu
Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.
FEBS letters 2006;580(22):5423-8.
2006: Jane M Knisely; Guojun Bu
Genetics and molecular biology: motive studies in mice--two NPXY motifs in the intracellular domain of lipoprotein receptor-related protein 1 exhibit differential importance during fetal development.
Current opinion in lipidology 2006;17(4):480-2.
2006: María-Paz Marzolo; Guojun Bu
Morphogens, new passengers on lipoprotein particles.
Current opinion in lipidology 2006;17(2):202-4.
2006: Simonetta Lisi; Roberta Botta; Aldo Pinchera; A Bernard Collins; Samuel Refetoff; Peter Arvan; Guojun Bu; Lucia Grasso; Vladimir Marshansky; Shaliha Bechoua; Andres Hurtado-Lorenzo; Claudio Marcocci; Dennis Brown; Robert T McCluskey; Michele Marinò
Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice.
American journal of physiology. Cell physiology 2006;290(4):C1160-7.
2006: Mary Jo Ladu; W Blaine Stine; Masaaki Narita; Godfrey S Getz; Catherine Reardon-Alulis; Guojun Bu
Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein.
Biochemistry 2006;45(2):381-90.
2006: Guo-Qiang Bi; Vadim Bolshakov; Guojun Bu; Catherine M Cahill; Zhou-Feng Chen; Graham Collingridge; Robin L Cooper; Jens R Coorssen; Alaa El-Husseini; Vasco Galhardo; Wen-Biao Gan; Jianguo Gu; Kazuhide Inoue; John Isaac; Koichi Iwata; Zhengping Jia; Bong-Kiun Kaang; Mikito Kawamata; Satoshi Kida; Eric Klann; Tatsuro Kohno; Min Li; Xiao-Jiang Li; John F MacDonald; Karim Nader; Peter V Nguyen; Uhtaek Oh; Ke Ren; John C Roder; Michael W Salter; Weihong Song; Shuzo Sugita; Shao-Jun Tang; YUANXIANG TAO; Yu Tian Wang; Newton Woo; Melanie A Woodin; Zhen Yan; Megumu Yoshimura; Ming Xu; Zao C Xu; Xia Zhang; Mei Zhen; Min Zhuo
Recent advances in basic neurosciences and brain disease: from synapses to behavior.
Molecular pain 2006;2():38.
2006: G. William Rebeck; Mary Jo Ladu; Steven Estus; Guojun Bu; Edwin J Weeber
The generation and function of soluble apoE receptors in the CNS.
Molecular neurodegeneration 2006;1():15.
2006: Judy A Cam; Guojun Bu
Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.
Molecular neurodegeneration 2006;1():8.
2005: Long-Jun Wu; Hiroki Toyoda; Ming-Gao Zhao; Yong-Seok Lee; Jianrong Tang; Shanelle W Ko; Yong Heng Jia; Fanny W F Shum; Celina V Zerbinatti; Guojun Bu; Feng Wei; Tian-Le Xu; Louis J Muglia; Zhou-Feng Chen; Yves P Auberson; Bong-Kiun Kaang; Min Zhuo
Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(48):11107-16.
2005: Yonghe Li; Jianglei Chen; Wenyan Lu; Lynn M McCormick; Jianjun Wang; Guojun Bu
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.
Journal of cell science 2005;118(Pt 22):5305-14.
2005: Yonghe Li; Guojun Bu
LRP5/6 in Wnt signaling and tumorigenesis.
Future oncology (London, England) 2005;1(5):673-81.
2005: Diana V Pastrana; Alison J Hanson; Jane Knisely; Guojun Bu; David J FitzGerald
LRP 1 B functions as a receptor for Pseudomonas exotoxin.
Biochimica et biophysica acta 2005;1741(3):234-9.
2005: Loreto Cuitino; Ricardo Matute; Claudio Retamal; Guojun Bu; Nibaldo C Inestrosa; María-Paz Marzolo
ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.
Traffic (Copenhagen, Denmark) 2005;6(9):820-38.
2005: Peter van Kerkhof; Jiyeon Lee; Lynn M McCormick; Elena Tetrault; Wenyan Lu; Marissa Schoenfish; Viola Oorschot; Ger J Strous; Judith Klumperman; Guojun Bu
Sorting nexin 17 facilitates LRP recycling in the early endosome.
The EMBO journal 2005;24(16):2851-61.
2005: Yonghe Li; Wenyan Lu; Guojun Bu
Striking differences of LDL receptor-related protein 1B expression in mouse and human.
Biochemical and biophysical research communications 2005;333(3):868-73.
2005: John D Fryer; Ronald B DeMattos; Lynn M McCormick; Mark A O'Dell; Michael L Spinner; Kelly R Bales; Steven M Paul; Patrick M. Sullivan; Maia Parsadanian; Guojun Bu; David M Holtzman
The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.
The Journal of biological chemistry 2005;280(27):25754-9.
2005: Pattie Green; Kelly Bales; Steven Paul; Guojun Bu
Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease.
Endocrinology 2005;146(6):2774-81.
2005: Karim Benchenane; Vincent Berezowski; Carine Ali; monica fernandez-monreal; José P López-Atalaya; julien brillault; Julien Chuquet; André Nouvelot; Eric T MacKenzie; Guojun Bu; Roméo Cecchelli; Omar Touzani; Denis Vivien
Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis.
Circulation 2005;111(17):2241-9.
2005: Lynn M McCormick; Reiko Urade; Yukino Arakaki; Alan L Schwartz; Guojun Bu
Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein.
Biochemistry 2005;44(15):5794-803.
2005: Judy A Cam; Celina V Zerbinatti; Yonghe Li; Guojun Bu
Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein.
The Journal of biological chemistry 2005;280(15):15464-70.
2005: Jiyeon Lee; Guojun Bu
Genetics and molecular biology: ABCA1 in brain apolipoprotein E metabolism and lipidation.
Current opinion in lipidology 2005;16(1):115-7.
2005: Celina V Zerbinatti; Guojun Bu
LRP and Alzheimer's disease.
Reviews in the neurosciences 2005;16(2):123-35.
2004: Yonghe Li; Wenyan Lu; Xi He; Alan L Schwartz; Guojun Bu
LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution.
Oncogene 2004;23(56):9129-35.
2004: Weihong Pan; Abba J Kastin; Todd C Zankel; Peter van Kerkhof; Tetsuya Terasaki; Guojun Bu
Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier.
Journal of cell science 2004;117(Pt 21):5071-8.
2004: William S Prince; Lynn M McCormick; Dan J Wendt; Paul A Fitzpatrick; Keri L Schwartz; Allora I Aguilera; Vishwanath Koppaka; Terri M Christianson; Michel C Vellard; Nadine Pavloff; Jeff F Lemontt; Minmin Qin; Chris M Starr; Guojun Bu; Todd C Zankel
Lipoprotein receptor binding, cellular uptake, and lysosomal delivery of fusions between the receptor-associated protein (RAP) and alpha-L-iduronidase or acid alpha-glucosidase.
The Journal of biological chemistry 2004;279(33):35037-46.
2004: Judy A Cam; Celina V Zerbinatti; Jane M Knisely; Silva Hecimovic; Yonghe Li; Guojun Bu
The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.
The Journal of biological chemistry 2004;279(28):29639-46.
2004: Yonghe Li; Guojun Bu
LRP5, a multifunctional cell surface receptor.
Current opinion in lipidology 2004;15(3):361-3.
2004: Yonghe Li; Wenyan Lu; Alan L Schwartz; Guojun Bu
Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway.
Journal of lipid research 2004;45(6):1084-91.
2004: monica fernandez-monreal; José P López-Atalaya; Karim Benchenane; Frederic Léveillé; Mathias Cacquevel; Laurent Plawinski; Eric T MacKenzie; Guojun Bu; Alain Buisson; Denis Vivien
Is tissue-type plasminogen activator a neuromodulator?
Molecular and cellular neurosciences 2004;25(4):594-601.
2004: Celina V Zerbinatti; David F Wozniak; John R Cirrito; Judy A Cam; Hiroshi Osaka; Kelly R Bales; Min Zhuo; Steven M Paul; David M Holtzman; Guojun Bu
Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):1075-80.
2003: Yonghe Li; Wenyan Lu; Guojun Bu
Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration.
FEBS letters 2003;555(2):346-50.
2003: Jane M Knisely; Guojun Bu
Genetics and molecular biology.
Current opinion in lipidology 2003;14(4):401-3.
2003: María-Paz Marzolo; María Isabel Yuseff; Claudio Retamal; Maribel Donoso; Fernando Ezquer; Pamela Farfán; Yonghe Li; Guojun Bu
Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains.
Traffic (Copenhagen, Denmark) 2003;4(4):273-88.
2002: Hiroko Shirotani-Ikejima; Koichi Kokame; Tsutomu Hamuro; Guojun Bu; Hisao Kato; Toshiyuki Miyata
Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs.
Biochemical and biophysical research communications 2002;299(5):847-52.
2002: Masaaki Narita; David M Holtzman; Anne M Fagan; Mary Jo Ladu; Li Yu; Xianlin Han; Richard W Gross; Guojun Bu; Alan L Schwartz
Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein.
Journal of biochemistry 2002;132(5):743-9.
2002: Yonghe Li; Jane M Knisely; Wenyan Lu; Lynn M McCormick; Jieyi Wang; Jack Henkin; Alan L Schwartz; Guojun Bu
Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration.
The Journal of biological chemistry 2002;277(44):42366-71.
2002: Pattie Green; Guojun Bu
Genetics and molecular biology: phosphorylation of low-density lipoprotein receptor-related protein by platelet-derived growth factor.
Current opinion in lipidology 2002;13(5):569-72.
2002: Yoshihisa Shibata; Takashi Muramatsu; Makoto Hirai; Tatsuya Inui; Terutoshi Kimura; Hidehiko Saito; Lynn M McCormick; Guojun Bu; Kenji Kadomatsu
Nuclear targeting by the growth factor midkine.
Molecular and cellular biology 2002;22(19):6788-96.
2002: Lora Melman; Hans J Geuze; Yonghe Li; Lynn M McCormick; Peter van Kerkhof; Ger J Strous; Alan L Schwartz; Guojun Bu
Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway.
Molecular biology of the cell 2002;13(9):3325-35.
2002: Jürgen Gent; Peter van Kerkhof; Marcel Roza; Guojun Bu; Ger J Strous
Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9858-63.
2002: Yonghe Li; Wenyan Lu; Alan L Schwartz; Guojun Bu
Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants.
Biochemistry 2002;41(15):4921-8.
2002: Hua-Poo Su; Kumiko Nakada-Tsukui; Annie-Carole Tosello-Trampont; Yonghe Li; Guojun Bu; Peter M Henson; Kodi S Ravichandran
Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).
The Journal of biological chemistry 2002;277(14):11772-9.
2002: Debi K Swertfeger; Guojun Bu; David Y Hui
Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration.
The Journal of biological chemistry 2002;277(6):4141-6.
2001: Mary Jo Ladu; JA Shah; Catherine Reardon-Alulis; Godfrey S Getz; Guojun Bu; J Hu; L Guo; Linda Van Eldik
Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses.
Neurochemistry international 2001;39(5-6):427-34.
2001: C X Liu; Yonghe Li; L M Obermoeller-McCormick; Alan L Schwartz; Guojun Bu
The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.
The Journal of biological chemistry 2001;276(31):28889-96.
2001: L Melman; Z F Cao; S Rennke; María-Paz Marzolo; Mark Wardell; Guojun Bu
High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifs.
The Journal of biological chemistry 2001;276(31):29338-46.
2001: Peter van Kerkhof; CM Alves dos Santos; Martin Sachse; Judith Klumperman; Guojun Bu; Ger J Strous
Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins.
Molecular biology of the cell 2001;12(8):2556-66.
2001: Yonghe Li; Wenyan Lu; María-Paz Marzolo; Guojun Bu
Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates.
The Journal of biological chemistry 2001;276(21):18000-6.
2001: L M Obermoeller-McCormick; Yonghe Li; H Osaka; D J FitzGerald; Alan L Schwartz; Guojun Bu
Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein.
Journal of cell science 2001;114(Pt 5):899-908.
2001: Yonghe Li; Judy A Cam; Guojun Bu
Low-density lipoprotein receptor family: endocytosis and signal transduction.
Molecular neurobiology 2001;23(1):53-67.
2001: Celina V Zerbinatti; Guojun Bu
Bimonthly update. Genetics and molecular biology.
Current opinion in lipidology 2001;12(1):77-9.
2001: Yonghe Li; Peter van Kerkhof; María-Paz Marzolo; Ger J Strous; Guojun Bu
Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis.
Molecular and cellular biology 2001;21(4):1185-95.
2001: Guojun Bu
The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family.
International review of cytology 2001;209():79-116.
2000: Ying Liu; Melina Jones; C M Hingtgen; Guojun Bu; N Laribee; Rudolph E Tanzi; Robert D. Moir; Avindra Nath; Johnny J He
Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.
Nature medicine 2000;6(12):1380-7.
2000: Mary Jo Ladu; JA Shah; Catherine Reardon-Alulis; Godfrey S Getz; Guojun Bu; J Hu; L Guo; Linda Van Eldik
Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures.
The Journal of biological chemistry 2000;275(43):33974-80.
2000: Y Li; María-Paz Marzolo; Peter van Kerkhof; Ger J Strous; Guojun Bu
The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein.
The Journal of biological chemistry 2000;275(22):17187-94.
2000: Guojun Bu; María-Paz Marzolo
Role of rap in the biogenesis of lipoprotein receptors.
Trends in cardiovascular medicine 2000;10(4):148-55.
2000: María-Paz Marzolo; Rommy Bernhardi; Guojun Bu; Nibaldo C Inestrosa
Expression of alpha(2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells.
Journal of neuroscience research 2000;60(3):401-11.
2000: Mary Jo Ladu; Catherine Reardon-Alulis; Linda Van Eldik; Anne M Fagan; Guojun Bu; David M Holtzman; Godfrey S Getz
Lipoproteins in the central nervous system.
Annals of the New York Academy of Sciences 2000;903():167-75.
2000: Min Zhuo; David M Holtzman; Y Li; H Osaka; JA DeMaro; M Jacquin; Guojun Bu
Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(2):542-9.
1999: Y Li; Guojun Bu
Genetics and molecular biology.
Current opinion in lipidology 1999;10(6):627-9.
1999: Roger Savonen; LM Obermoeller; Julie S Trausch-Azar; Alan L Schwartz; Guojun Bu
The carboxyl-terminal domain of receptor-associated protein facilitates proper folding and trafficking of the very low density lipoprotein receptor by interaction with the three amino-terminal ligand-binding repeats of the receptor.
The Journal of biological chemistry 1999;274(36):25877-82.
1999: K L Moulder; M Narita; L K Chang; Guojun Bu; E M Johnson
Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide.
Journal of neurochemistry 1999;72(3):1069-80.
1999: Anne Hamik; Hendra Setiadi; Guojun Bu; Rodger P McEver; James Morrissey
Down-regulation of monocyte tissue factor mediated by tissue factor pathway inhibitor and the low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1999;274(8):4962-9.
1998: S C Rall; P Ye; Guojun Bu; Mark Wardell
The domain structure of human receptor-associated protein. Protease sensitivity and guanidine HCl denaturation.
The Journal of biological chemistry 1998;273(37):24152-7.
1998: LM Obermoeller; Z Chen; Alan L Schwartz; Guojun Bu
Ca2+ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1998;273(35):22374-81.
1998: Guojun Bu; A L Schwartz
RAP, a novel type of ER chaperone.
Trends in cell biology 1998;8(7):272-6.
1998: Anne M Fagan; B A Murphy; S N Patel; JF Kilbridge; William C. Mobley; Guojun Bu; David M Holtzman
Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.
Experimental neurology 1998;151(2):314-25.
1998: Guojun Bu; Y Sun; Alan L Schwartz; David M Holtzman
Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1998;273(21):13359-65.
1998: Y Sun; S Wu; Guojun Bu; M K Onifade; S N Patel; Mary Jo Ladu; Anne M Fagan; David M Holtzman
Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(9):3261-72.
1998: Guojun Bu
Receptor-associated protein: a specialized chaperone and antagonist for members of the LDL receptor gene family.
Current opinion in lipidology 1998;9(2):149-55.
1997: M Narita; David M Holtzman; Alan L Schwartz; Guojun Bu
Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.
Journal of neurochemistry 1997;69(5):1904-11.
1997: LM Obermoeller; I Warshawsky; Mark Wardell; Guojun Bu
Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone.
The Journal of biological chemistry 1997;272(16):10761-8.
1997: ZS Farhangrazi; Howard S Ying; Guojun Bu; Laura L Dugan; A M Fagan; Dennis Choi; David M Holtzman
High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture.
Neuroreport 1997;8(5):1127-30.
1997: M M Hardy; J Feder; R A Wolfe; Guojun Bu
Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts.
The Journal of biological chemistry 1997;272(10):6812-7.
1997: M Narita; Guojun Bu; David M Holtzman; Alan L Schwartz
The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development.
Journal of neurochemistry 1997;68(2):587-95.
1997: Guojun Bu; S Rennke; Hans J Geuze
ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP).
Journal of cell science 1997;110 ( Pt 1)():65-73.
1996: Anne M Fagan; Guojun Bu; Y Sun; A Daugherty; David M Holtzman
Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1996;271(47):30121-5.
1996: Guojun Bu; S Rennke
Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1996;271(36):22218-24.
1995: M Narita; Guojun Bu; G M Olins; D A Higuchi; Joachim Herz; George J Broze; Alan L Schwartz
Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo.
The Journal of biological chemistry 1995;270(42):24800-4.
1995: David M Holtzman; R E Pitas; J Kilbridge; Britto P. Nathan; Robert W Mahley; Guojun Bu; A L Schwartz
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9480-4.
1995: M Narita; Guojun Bu; Joachim Herz; Alan L Schwartz
Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo.
The Journal of clinical investigation 1995;96(2):1164-8.
1995: Kim Vettenranta; Guojun Bu; Alan L Schwartz
Binding and endocytosis of 39 kDa protein by MDBK cells.
Journal of cellular physiology 1995;164(2):441-7.
1995: Guojun Bu; H J Geuze; G J Strous; Alan L Schwartz
39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein.
The EMBO journal 1995;14(10):2269-80.
1995: I Warshawsky; Guojun Bu; A Mast; J E Saffitz; George J Broze; Alan L Schwartz
The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo.
The Journal of clinical investigation 1995;95(4):1773-81.
1995: I Warshawsky; Guojun Bu; Alan L Schwartz
Sites within the 39-kDa protein important for regulating ligand binding to the low-density lipoprotein receptor-related protein.
Biochemistry 1995;34(10):3404-15.
1994: Guojun Bu; E A Maksymovitch; H Geuze; Alan L Schwartz
Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells.
The Journal of biological chemistry 1994;269(47):29874-82.
1994: I Warshawsky; Guojun Bu; Alan L Schwartz
LRP and the receptor-mediated endocytosis of plasminogen activators.
Annals of the New York Academy of Sciences 1994;737():70-87.
1994: I Warshawsky; Guojun Bu; Alan L Schwartz
Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor--related protein.
Annals of the New York Academy of Sciences 1994;737():514-7.
1994: Guojun Bu; E A Maksymovitch; J M Nerbonne; Alan L Schwartz
Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons.
The Journal of biological chemistry 1994;269(28):18521-8.
1994: Guojun Bu; I Warshawsky; Alan L Schwartz
Cellular receptors for the plasminogen activators.
Blood 1994;83(12):3427-36.
1994: I Warshawsky; Guojun Bu; Alan L Schwartz
Binding analysis of amino-terminal and carboxyl-terminal regions of the 39-kDa protein to the low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1994;269(5):3325-30.
1993: S P Iadonato; Guojun Bu; E A Maksymovitch; Alan L Schwartz
Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells.
The Biochemical journal 1993;296 ( Pt 3)():867-75.
1993: I Warshawsky; Guojun Bu; Alan L Schwartz
Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1993;268(29):22046-54.
1993: I Warshawsky; Guojun Bu; Alan L Schwartz
39-kD protein inhibits tissue-type plasminogen activator clearance in vivo.
The Journal of clinical investigation 1993;92(2):937-44.
1993: Guojun Bu; E A Maksymovitch; Alan L Schwartz
Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells.
The Journal of biological chemistry 1993;268(17):13002-9.
1992: Guojun Bu; S Williams; Dudley K Strickland; Alan L Schwartz
Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7427-31.
1992: Guojun Bu; P A Morton; Alan L Schwartz
Identification and partial characterization by chemical cross-linking of a binding protein for tissue-type plasminogen activator (t-PA) on rat hepatoma cells. A plasminogen activator inhibitor type 1-independent t-PA receptor.
The Journal of biological chemistry 1992;267(22):15595-602.