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Jan Potempa

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D P Byrne; Teresa Olczak; Jan Potempa; John W Smalley
Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia.
Ronan K Carroll; Marcin Drag; Danielle T Gagne; Jarrod M Lindenmuth; Marcin Poreba; Jan Potempa; Florian Veillard; Lindsey N Shaw
The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine.
Sabrina Ruggiero; Raluca Cosgarea; Sigrun Eick; Barbara Potempa; Jan Potempa; Matthias Chiquet
Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C.

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All Publications

2013: D P Byrne; Teresa Olczak; Jan Potempa; John W Smalley
Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia.
Molecular oral microbiology 2013;28(3):219-29.
2013: Ronan K Carroll; Marcin Drag; Danielle T Gagne; Jarrod M Lindenmuth; Marcin Poreba; Jan Potempa; Florian Veillard; Lindsey N Shaw
The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine.
Biological chemistry 2013;394(6):791-803.
2013: Sabrina Ruggiero; Raluca Cosgarea; Sigrun Eick; Barbara Potempa; Jan Potempa; Matthias Chiquet
Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C.
Biochimica et biophysica acta 2013;1832(4):517-26.
2013: Krzysztof Pyrc; Karol Stożek; Wojciech Galan; Jan Potempa
HexaPrime: a novel method for detection of coronaviruses.
Journal of virological methods 2013;188(1-2):29-36.
2013: Annelie Hellvard; Roland Jonsson; Katarzyna Maresz; Holger Cynis; Hans-Ulrich Demuth; Sigrid Graubner; Ulrich Heiser; Jan Potempa; Stephan Schilling; Piotr Mydel
Glutaminyl cyclases as novel targets for the treatment of septic arthritis.
The Journal of infectious diseases 2013;207(5):768-77.
2013: Aleksandra Milewska; Maria Nowakowska; Jan Potempa; Krzysztof Pyrc; Dorota Bielska; Berend Jan Bosch; Justyna Ciejka; Kamil Kaminski; Anna Karewicz; Wojciech Karolak; Slawomir Zeglen; Krzysztof Szczubialka
Novel polymeric inhibitors of HCoV-NL63.
Antiviral research 2013;97(2):112-21.
2013: Joanna Koziel; Jan Potempa
Protease-armed bacteria in the skin.
Cell and tissue research 2013;351(2):325-37.
2013: Joanna Koziel; Agnieszka Maciag-Gudowska; Katarzyna Maresz; Danuta Mizgalska; Piotr Mydel; Daniela Chmiest; Katarzyna Kmiecik; Jan Potempa
The role of Mcl-1 in S. aureus-induced cytoprotection of infected macrophages.
Mediators of inflammation 2013;2013():427021.
2013: Tomasz Kantyka; Marek Ochman; Karolina Plaza; Milosz Gruca; Krzysztof Guzik; Krzysztof Pyrc; Jan Smagur; Slawomir Zeglen; Jan Potempa
Staphylococcus aureus proteases degrade lung surfactant protein A potentially impairing innate immunity of the lung.
Journal of innate immunity 2013;5(3):251-60.
2013: Krzysztof Pyrc; Aneta Sroka; Joanna Kozieł; Jan J Enghild; Tomasz Kantyka; Anders Dahl Knudsen; Katarzyna Maresz; Aleksandra Milewska; Ky-Anh Nguyen; Jan Potempa
Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage.
Infection and immunity 2013;81(1):55-64.
2013: Grzegorz Dubin; Joanna Koziel; Krzysztof Pyrc; Benedykt Wladyka; Jan Potempa
Bacterial proteases in disease - role in intracellular survival, evasion of coagulation/ fibrinolysis innate defenses, toxicoses and viral infections.
Current pharmaceutical design 2013;19(6):1090-113.
2013: E Blazusiak; D Florczyk; Jolanta Jura; Jan Potempa; J Koziel
Differential regulation by Toll-like receptor agonists reveals that MCPIP1 is the potent regulator of innate immunity in bacterial and viral infections.
Journal of innate immunity 2013;5(1):15-23.
2012: Florian Veillard; Marcin Drag; Marcin Poreba; Barbara Potempa; Jan Potempa
Gingipain aminopeptidase activities in Porphyromonas gingivalis.
Biological chemistry 2012;393(12):1471-6.
2012: Michal Zdzalik; Sarah Brueggemann; Pawel Buda; Ann-Marie Calander; Sigrun Eick; Ing-Marie Jonsson; Abdulkarim Y Karim; Malgorzata Kubica; Jacek Miedzobrodzki; Klaudia Polakowska; Jan Potempa; Benedykt Wladyka; Piotr Wojciechowski; Kinga Wojcik; Krzysztof Wolski; Grzegorz Dubin
Prevalence of genes encoding extracellular proteases in Staphylococcus aureus - important targets triggering immune response in vivo.
FEMS immunology and medical microbiology 2012;66(2):220-9.
2012: Maryta Sztukowska; Ida B Thogersen; Florian Veillard; Matthew Bogyo; Jan J Enghild; Ky-Anh Nguyen; Barbara Potempa; Jan Potempa
Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes.
Biological chemistry 2012;393(9):971-7.
2012: Ronan K Carroll; Jessica E Davenport; Danuta Florczyk; Ing-Marie Jonsson; Joanna Koziel; Jan Potempa; Frances E Rivera; Tiffany M Robison; Andrej Tarkowski; Lindsey N Shaw
Identification of an intracellular M17 family leucine aminopeptidase that is required for virulence in Staphylococcus aureus.
Microbes and infection / Institut Pasteur 2012;14(11):989-99.
2012: Joanna Skrzeczynska-Moncznik; Agnieszka Wlodarczyk; Katarzyna Zabieglo; Adam Dubin; Monika Kapinska-Mrowiecka; Ewa Marewicz; Jan Potempa; Joanna Cichy
Secretory leukocyte proteinase inhibitor-competent DNA deposits are potent stimulators of plasmacytoid dendritic cells: implication for psoriasis.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1611-7.
2012: Monika Jusko; Abdulkarim Y Karim; Miroslaw Ksiazek; Jan Potempa; Kristian Riesbeck; Sigrun Eick; Peter Garred; Anna M Blom
A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(5):2338-49.
2012: Wieslaw Dobros; Krzysztof Guzik; Joanna Koziel; Karolina Burda; Jan Potempa
Apoptotic cell clearance in chronic inflammation of lateral neck cysts.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2012;269(3):965-70.
2012: O Laugisch; Wolfgang Pfister; Jan Potempa; M Schacht; Anton Sculean; Aneta Sroka; Henning Stennicke; Arndt Guentsch; T Kantyka; Sigrun Eick
Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid.
Molecular oral microbiology 2012;27(1):45-56.
2012: Magdalena Kalińska; Tomasz Kantyka; Katrine S Larsen; Adam Lesner; Jan Potempa; Krzysztof Rolka; Norbert Schaschke; Henning Stennicke; Benedykt Władyka; Magdalena Wysocka; Matthew Bogyo; Patrick S Daugherty; Adam Dubin; Doron C Greenbaum; Abeer Jabaiah; Marcelina Jaros; Grzegorz Dubin
Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.
Biochimie 2012;94(2):318-27.
2012: Karina Adamowicz; Ravi Jotwani; Jan Potempa; Huizhi Wang; Iris Zeller; David A Scott
Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice.
Molecular medicine (Cambridge, Mass.) 2012;18():1190-6.
2012: Sven Malm; Jan Potempa; Kristian Riesbeck; Sigrun Eick; Monika Jusko; Anna Blom
Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia.
PloS one 2012;7(4):e34852.
2012: Krzysztof Pyrc; Marek Sanak; Karol Stożek; Andrzej Szczeklik; Jacek Wojarski; Krzysztof Wojcik; Slawomir Zeglen; Marian Zembala; Grazyna Bochenek; Katarzyna Maria Gawron; Magdalena Hubalewska-Mazgaj; Wojciech Karolak; Marek Ochman; Jan Potempa
Use of sensitive, broad-spectrum molecular assays and human airway epithelium cultures for detection of respiratory pathogens.
PloS one 2012;7(3):e32582.
2012: Jan Potempa
Posttranslational modifications in innate immunity.
Journal of innate immunity 2012;4(2):119-20.
2011: Bjarne Vincents; Ulrich von Pawel-Rammingen; Sigrun Eick; Arndt Guentsch; Dominika Kostolowska; Jan Potempa; Magnus Abrahamson
Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(10):3741-50.
2011: Krzysztof Pyrc; Oliver Schildgen; Paulina Strzyz; Anna Golda; Aleksandra Milewska; Jan Potempa
Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro.
The Journal of general virology 2011;92(Pt 10):2324-32.
2011: Paulina Kulig; Jan Potempa; Anna Stefanska; Hua Tu; Brian A Zabel; Samantha J Allen; Magdalena Banas; Eugene C Butcher; Agnieszka Chyra; Tracy M Handel; Tomasz Kantyka; Andrzej Kozik; Joanna Cichy
Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1403-10.
2011: Stacey L Kolar; Joanna Koziel; Halie K Miller; Vijayaraj Nagarajan; Anna Oszmiana; Jan Potempa; James T Riordan; Frances E Rivera; David S Barber; Jessica E Davenport; Mohamed O Elasri; Lindsey N Shaw
NsaRS is a cell-envelope-stress-sensing two-component system of Staphylococcus aureus.
Microbiology (Reading, England) 2011;157(Pt 8):2206-19.
2011: Krzysztof Pyrc; Aleksandra Milewska; Jan Potempa
Development of loop-mediated isothermal amplification assay for detection of human coronavirus-NL63.
Journal of virological methods 2011;175(1):133-6.
2011: Arndt Guentsch; Martin Kramesberger; Wolfgang Pfister; Jan Potempa; Aneta Sroka; Sigrun Eick
Comparison of gingival crevicular fluid sampling methods in patients with severe chronic periodontitis.
Journal of periodontology 2011;82(7):1051-60.
2011: Anna Golda; Natalia Malek; Bartosz Dudek; Slawomir Zeglen; Jacek Wojarski; Marek Ochman; Ewa Kucewicz; Marian Zembala; Jan Potempa; Krzysztof Pyrc
Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells.
The Journal of general virology 2011;92(Pt 6):1358-68.
2011: Tomasz Kantyka; Karolina Plaza; Joanna Koziel; Danuta Florczyk; Henning Stennicke; Ida B Thogersen; Jan J Enghild; Gary A Silverman; Stephen C Pak; Jan Potempa
Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence.
Biological chemistry 2011;392(5):483-9.
2011: Takehisa Ohbayashi; Atsushi Irie; Yoji Murakami; Magdalena Nowak; Jan Potempa; Yasuharu Nishimura; Masanori Shinohara; Takahisa Imamura
Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus.
Microbiology (Reading, England) 2011;157(Pt 3):786-92.
2011: Maria Rapala-Kozik; Grazyna Bras; Barbara Chruscicka; Justyna Karkowska-Kuleta; Aneta Sroka; Heiko Herwald; Ky-Anh Nguyen; Sigrun Eick; Jan Potempa; Andrzej Kozik
Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.
Infection and immunity 2011;79(2):797-805.
2011: Tomasz Kantyka; Jan Potempa
Human SCCA serpins inhibit staphylococcal cysteine proteases by forming classic "serpin-like" covalent complexes.
Methods in enzymology 2011;499():331-45.
2011: Tang Yongqing; Robert N Pike; Jan Potempa; Lakshmi C Wijeyewickrema
The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition.
Advances in experimental medicine and biology 2011;712():15-29.
2011: Tomasz Kantyka; Lindsey N Shaw; Jan Potempa
Papain-like proteases of Staphylococcus aureus.
Advances in experimental medicine and biology 2011;712():1-14.
2011: Krzysztof Guzik; J Skret; J Smagur; Malgorzata Bzowska; Barbara Gajkowska; D A Scott; Jan Potempa
Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages.
Cell death & disease 2011;2():e131.
2011: John W Smalley; Dominic P Byrne; Andrew J Birss; Halina Wójtowicz; Aneta Sroka; Jan Potempa; Teresa Olczak
HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis.
PloS one 2011;6(2):e17182.
2011: Núria Cerdà-Costa; Tibisay Guevara; Abdulkarim Y Karim; Miroslaw Ksiazek; Ky-Anh Nguyen; Joan L Arolas; Jan Potempa; F Xavier Gomis-Rüth
The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases.
Molecular microbiology 2011;79(1):119-32.
2010: Michal Zdzalik; Katarzyna Pustelny; Sylwia Kedracka-Krok; Krzysztof Huben; Aleksandra Pecak; Benedykt Wladyka; Stefan Jankowski; Adam Dubin; Jan Potempa; Grzegorz Dubin
Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73.
Cell cycle (Georgetown, Tex.) 2010;9(22):4584-91.
2010: Tomasz Kantyka; Neil D Rawlings; Jan Potempa
Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function.
Biochimie 2010;92(11):1644-56.
2010: Yonghua Guo; Ky-Anh Nguyen; Jan Potempa
Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins.
Periodontology 2000 2010;54(1):15-44.
2010: Kazuyuki Ishihara; Katarzyna Wawrzonek; Lindesey N Shaw; Satoru Inagaki; Meguru Miyamoto; Jan Potempa
Dentipain, a Streptococcus pyogenes IdeS protease homolog, is a novel virulence factor of Treponema denticola.
Biological chemistry 2010;391(9):1047-55.
2010: Natalia Wegner; Robin Wait; Aneta Sroka; Sigrun Eick; Ky-Anh Nguyen; Karin Lundberg; Andrew Kinloch; Shauna Culshaw; Jan Potempa; Patrick J Venables
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis.
Arthritis and rheumatism 2010;62(9):2662-72.
2010: Jennifer L Krauss; Jan Potempa; John D Lambris; George Hajishengallis
Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host.
Periodontology 2000 2010;52(1):141-62.
2010: Abdulkarim Y Karim; Magdalena Kulczycka; Tomasz Kantyka; Grzegorz Dubin; Abeer Jabaiah; Patrick S Daugherty; Ida B Thogersen; Jan J Enghild; Ky-Anh Nguyen; Jan Potempa
A novel matrix metalloprotease-like enzyme (karilysin) of the periodontal pathogen Tannerella forsythia ATCC 43037.
Biological chemistry 2010;391(1):105-17.
2010: Dominic P Byrne; Katarzyna Wawrzonek; Anna Jaworska; Andrew J Birss; Jan Potempa; John W Smalley
Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin.
The Biochemical journal 2010;425(1):257-64.
2009: Tomasz Kantyka; Ties Latendorf; Oliver Wiedow; Joachim Bartels; Regine Gläser; Grzegorz Dubin; Jens-Michael Schröder; Jan Potempa; Ulf Meyer-Hoffert
Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage.
Biological chemistry 2009;390(12):1313-20.
2009: Ana Carolina Monteiro; Aline Scovino; Susane Raposo; Vinicius Mussa Gaze; Catia Cruz; Erik Svensjö; Marcelo Sampaio Narciso; Ana Paula Colombo; João B Pesquero; Eduardo Feres-Filho; Ky-Anh Nguyen; Aneta Sroka; Jan Potempa; Julio Scharfstein
Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3700-11.
2009: R E Fitzpatrick; P D Campbell; S Sivagurunathan; Charles N Pagel; Jan Potempa; Eleanor J Mackie; Robert N Pike
The gingipains from Porphyromonas gingivalis do not directly induce osteoclast differentiation in primary mouse bone marrow cultures.
Journal of periodontal research 2009;44(4):565-7.
2009: Arndt Guentsch; M Puklo; Philip M Preshaw; Eike Glockmann; Wolfgang Pfister; Jan Potempa; Sigrun Eick
Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.
Journal of periodontal research 2009;44(3):368-77.
2009: A D McAlister; A Sroka; R E Fitzpatrick; Noelene S Quinsey; James Travis; Jan Potempa; Robert N Pike
Gingipain enzymes from Porphyromonas gingivalis preferentially bind immobilized extracellular proteins: a mechanism favouring colonization?
Journal of periodontal research 2009;44(3):348-53.
2009: Halina Wójtowicz; Tibisay Guevara; Cynthia Tallant; Mariusz Olczak; Aneta Sroka; Jan Potempa; Maria Solà; Teresa Olczak; F Xavier Gomis-Rüth
Unique structure and stability of HmuY, a novel heme-binding protein of Porphyromonas gingivalis.
PLoS pathogens 2009;5(5):e1000419.
2009: Justyna Stec-Niemczyk; Katarzyna Pustelny; Magdalena Kisielewska; Michal Bista; Kevin T Boulware; Henning Stennicke; Ida B Thogersen; Patrick S Daugherty; Jan J Enghild; Krzysztof Baczynski; Grzegorz M Popowicz; Adam Dubin; Jan Potempa; Grzegorz Dubin
Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus.
The Biochemical journal 2009;419(3):555-64.
2009: Jan Smagur; Krzysztof Guzik; Malgorzata Bzowska; Mateusz Kuzak; Miroslaw Zarebski; Tomasz Kantyka; Michal Walski; Barbara Gajkowska; Jan Potempa
Staphylococcal cysteine protease staphopain B (SspB) induces rapid engulfment of human neutrophils and monocytes by macrophages.
Biological chemistry 2009;390(4):361-71.
2009: Rika Yasuhara; Yoichi Miyamoto; Masamichi Takami; Takahisa Imamura; Jan Potempa; Kentaro Yoshimura; Ryutaro Kamijo
Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin.
The Biochemical journal 2009;419(1):159-66.
2009: Michal Potempa; Jan Potempa; Tomasz Kantyka; Ky-Anh Nguyen; Katarzyna Wawrzonek; Surya P Manandhar; Katarzyna Popadiak; Kristian Riesbeck; Sigrun Eick; Anna Blom
Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3.
PLoS pathogens 2009;5(2):e1000316.
2009: Ky-Anh Nguyen; Jasiek Zylicz; Pawel Szczesny; Aneta Sroka; Neil Hunter; Jan Potempa
Verification of a topology model of PorT as an integral outer-membrane protein in Porphyromonas gingivalis.
Microbiology (Reading, England) 2009;155(Pt 2):328-37.
2009: Rebecca E Fitzpatrick; Andrea Aprico; Lakshmi C Wijeyewickrema; Charles N Pagel; David M Wong; Jan Potempa; Eleanor J Mackie; Robert N Pike
High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism.
Journal of innate immunity 2009;1(2):109-17.
2009: Jan Smagur; Krzysztof Guzik; Lukasz Magiera; Malgorzata Bzowska; Milosz Gruca; Ida B Thøgersen; Jan J Enghild; Jan Potempa
A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes.
Journal of innate immunity 2009;1(2):98-108.
2009: Jan Potempa; Robert N Pike
Corruption of innate immunity by bacterial proteases.
Journal of innate immunity 2009;1(2):70-87.
2009: Panagiota Giorgios Stathopoulou; Johnah Galicia; Manjunatha Benakanakere; Carlos A Garcia; Jan Potempa; Denis F Kinane
Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism.
BMC microbiology 2009;9():107.
2009: Joanna Koziel; Agnieszka Maciag-Gudowska; Tomasz Mikolajczyk; Malgorzata Bzowska; Daniel E Sturdevant; Adeline R Whitney; Lindsey N Shaw; Frank R DeLeo; Jan Potempa
Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors.
PloS one 2009;4(4):e5210.
2008: Michal Potempa; Jan Potempa; Marcin Okroj; Katarzyna Popadiak; Sigrun Eick; Ky-Anh Nguyen; Kristian Riesbeck; Anna Blom
Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5537-44.
2008: John W Smalley; Andrew J Birss; Borys Szmigielski; Jan Potempa
Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis.
Biological chemistry 2008;389(9):1235-8.
2008: M Puklo; Arndt Guentsch; P S Hiemstra; S Eick; Jan Potempa
Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria.
Oral microbiology and immunology 2008;23(4):328-35.
2008: Grzegorz Dubin; Justyna Stec-Niemczyk; Magdalena Kisielewska; Katarzyna Pustelny; Grzegorz M Popowicz; Michal Bista; Tomasz Kantyka; Kevin T Boulware; Henning Stennicke; Anna Czarna; Mullika Phopaisarn; Patrick S Daugherty; Ida B Thøgersen; Jan J Enghild; Nancy Thornberry; Adam Dubin; Jan Potempa
Enzymatic activity of the Staphylococcus aureus SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln.
Journal of molecular biology 2008;379(2):343-56.
2008: A Uehara; T Imamura; Jan Potempa; J Travis; H Takada
Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and NOD1/2 ligands in human monocytic cells.
Cellular microbiology 2008;10(5):1181-9.
2008: Akiko Uehara; Mariko Naito; Takahisa Imamura; Jan Potempa; James Travis; Koji Nakayama; Haruhiko Takada
Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis.
Journal of medical microbiology 2008;57(Pt 4):500-7.
2008: Ann-Marie Calander; Grzegorz Dubin; Jan Potempa; Andrej Tarkowski
Staphylococcus aureus infection triggers production of neutralizing, V8 protease-specific antibodies.
FEMS immunology and medical microbiology 2008;52(2):267-72.
2008: Teresa Olczak; Aneta Sroka; Jan Potempa; Mariusz Olczak
Porphyromonas gingivalis HmuY and HmuR: further characterization of a novel mechanism of heme utilization.
Archives of microbiology 2008;189(3):197-210.
2008: Nathalie Beaufort; Piotr Wojciechowski; Christian P Sommerhoff; Grzegorz Szmyd; Grzegorz Dubin; Sigrun Eick; Josef Kellermann; Manfred Schmitt; Jan Potempa; Viktor Magdolen
The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin.
The Biochemical journal 2008;410(1):157-65.
2008: Noemí Mallorquí-Fernández; Surya P Manandhar; Goretti Mallorquí-Fernández; Isabel Usón; Katarzyna Wawrzonek; Tomasz Kantyka; Maria Solà; Ida B Thøgersen; Jan J Enghild; Jan Potempa; F Xavier Gomis-Rüth
A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A.
The Journal of biological chemistry 2008;283(5):2871-82.
2008: Krzysztof Guzik; Jan Potempa
Friendly fire against neutrophils: proteolytic enzymes confuse the recognition of apoptotic cells by macrophages.
Biochimie 2008;90(2):405-15.
2008: Elisabet Josefsson; Malgorzata Kubica; Piotr M Mydel; Jan Potempa; Andrej Tarkowski
In vivo sortase A and clumping factor A mRNA expression during Staphylococcus aureus infection.
Microbial pathogenesis 2008;44(2):103-10.
2008: Lindsey N Shaw; Catharina Lindholm; Tomasz K Prajsnar; Halie K Miller; Melanie C Brown; Ewa Golonka; George C Stewart; Andrej Tarkowski; Jan Potempa
Identification and characterization of sigma, a novel component of the Staphylococcus aureus stress and virulence responses.
PloS one 2008;3(12):e3844.
2008: Malgorzata Kubica; Krzysztof Guzik; Joanna Koziel; Miroslaw Zarebski; Walter Richter; Barbara Gajkowska; Anna Golda; Agnieszka Maciag-Gudowska; Klaudia Brix; Les Shaw; Timothy Foster; Jan Potempa
A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages.
PloS one 2008;3(1):e1409.
2007: Ebru Kirdis; Ing-Marie Jonsson; Malgorzata Kubica; Jan Potempa; Elisabet Josefsson; MAHMUD MASALHA; Simon J Foster; Andrej Tarkowski
Ribonucleotide reductase class III, an essential enzyme for the anaerobic growth of Staphylococcus aureus, is a virulence determinant in septic arthritis.
Microbial pathogenesis 2007;43(5-6):179-88.
2007: John W Smalley; Andrew J Birss; Borys Szmigielski; Jan Potempa
Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin.
Archives of biochemistry and biophysics 2007;465(1):44-9.
2007: Jan Potempa; Ky-Anh Nguyen
Purification and characterization of gingipains.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2007;Chapter 21():Unit 21.20.
2007: Katarzyna Popadiak; Jan Potempa; Kristian Riesbeck; Anna Blom
Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7242-50.
2007: Zuzana Valnickova; Ida B Thøgersen; Jan Potempa; Jan J Enghild
The intrinsic enzymatic activity of procarboxypeptidase U (TAFI) does not significantly influence the fibrinolytic rate: reply to a rebuttal.
Journal of thrombosis and haemostasis : JTH 2007;5(6):1336-7.
2007: Bjarne Vincents; Patrik Onnerfjord; Milosz Gruca; Jan Potempa; Magnus Abrahamson
Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B.
Biological chemistry 2007;388(4):437-46.
2007: Paulina Kulig; Brian A Zabel; Grzegorz Dubin; Samantha J Allen; Takao Ohyama; Jan Potempa; Tracy M Handel; Eugene C Butcher; Joanna Cichy
Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3713-20.
2007: Zuzana Valnickova; Ida B Thøgersen; Jan Potempa; Jan J Enghild
Thrombin-activable fibrinolysis inhibitor (TAFI) zymogen is an active carboxypeptidase.
The Journal of biological chemistry 2007;282(5):3066-76.
2007: Grzegorz Dubin; Benedykt Wladyka; Justyna Stec-Niemczyk; Dorota Chmiel; Michal Zdzalik; Adam Dubin; Jan Potempa
The staphostatin family of cysteine protease inhibitors in the genus Staphylococcus as an example of parallel evolution of protease and inhibitor specificity.
Biological chemistry 2007;388(2):227-35.
2007: Ky-Anh Nguyen; James Travis; Jan Potempa
Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria?
Journal of bacteriology 2007;189(3):833-43.
2007: Krzysztof Guzik; Malgorzata Bzowska; J Smagur; O Krupa; M Sieprawska; James Travis; Jan Potempa
A new insight into phagocytosis of apoptotic cells: proteolytic enzymes divert the recognition and clearance of polymorphonuclear leukocytes by macrophages.
Cell death and differentiation 2007;14(1):171-82.
2006: Shaun M Sheets; Jan Potempa; James Travis; Hansel M Fletcher; Carlos A Casiano
Gingipains from Porphyromonas gingivalis W83 synergistically disrupt endothelial cell adhesion and can induce caspase-independent apoptosis.
Infection and immunity 2006;74(10):5667-78.
2006: Lindsey N Shaw; Joanne L Aish; Jessica E Davenport; Melanie C Brown; James K Lithgow; Kay Simmonite; Howard Crossley; James Travis; Jan Potempa; Simon J Foster
Investigations into sigmaB-modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus.
Journal of bacteriology 2006;188(17):6070-80.
2006: C A Cronan; Jan Potempa; James Travis; John A Mayo
Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II).
Oral microbiology and immunology 2006;21(4):212-7.
2006: Jonathan Moon; Lindsey N Shaw; John A Mayo; Jan Potempa; James Travis
Isolation and properties of extracellular proteinases of Penicillium marneffei.
Biological chemistry 2006;387(7):985-93.
2006: Nancy R Matheson; Jan Potempa; James Travis
Interaction of a novel form of Pseudomonas aeruginosa alkaline protease (aeruginolysin) with interleukin-6 and interleukin-8.
Biological chemistry 2006;387(7):911-5.
2006: Piotr M Mydel; Yusuke Takahashi; Hiromichi Yumoto; Maryta Sztukowska; Malgorzata Kubica; Frank C Gibson; Donald M Kurtz; James Travis; L Vincent Collins; Ky-Anh Nguyen; Caroline Attardo Genco; Jan Potempa
Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection.
PLoS pathogens 2006;2(7):e76.
2006: John W Smalley; Andrew J Birss; B Szmigielski; Jan Potempa
The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes micro-oxo bishaem formation from monomeric iron(III) protoporphyrin IX.
Microbiology (Reading, England) 2006;152(Pt 6):1839-45.
2006: Kenji Matsushita; Takahisa Imamura; Salunya tancharoen; Syouko Tatsuyama; Munehiro Tomikawa; James Travis; Jan Potempa; Mitsuo Torii; Ikuro Maruyama
Selective inhibition of Porphyromonas gingivalis growth by a factor Xa inhibitor, DX-9065a.
Journal of periodontal research 2006;41(3):171-6.
2006: Grzegorz M Popowicz; Grzegorz Dubin; Justyna Stec-Niemczyk; Anna Czarny; Adam Dubin; Jan Potempa; Tad A Holak
Functional and structural characterization of Spl proteases from Staphylococcus aureus.
Journal of molecular biology 2006;358(1):270-9.
2006: Arkadiusz Białas; Jolanta Grembecka; Daniel Krowarsch; Jacek Otlewski; Jan Potempa; Artur Mucha
Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity.
Journal of medicinal chemistry 2006;49(5):1744-53.
2006: Jan Potempa; James Travis; Ewa Golonka; Ln Shaw
Poison-antidote systems in bacteria: the co-evolution of functional counterparts.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(4):18-22.
2005: Akiko Uehara; Koji Muramoto; Takahisa Imamura; Koji Nakayama; Jan Potempa; James Travis; Shunji Sugawara; Haruhiko Takada
Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6076-84.
2005: Thomas M Krunkosky; Keishi Maruo; Jan Potempa; Carla L Jarrett; James Travis
Inhibition of tumor necrosis factor-alpha-induced RANTES secretion by alkaline protease in A549 cells.
American journal of respiratory cell and molecular biology 2005;33(5):483-9.
2005: Renata Mezyk-Kopeć; Malgorzata Bzowska; Monika Bzowska; Barbara Mickowska; Pawel Mak; Jan Potempa; Joanna Bereta
Effects of elastase and cathepsin G on the levels of membrane and soluble TNFalpha.
Biological chemistry 2005;386(8):801-11.
2005: Jan Potempa; Ewa Golonka; Renata Filipek; Lindsey N Shaw
Fighting an enemy within: cytoplasmic inhibitors of bacterial cysteine proteases.
Molecular microbiology 2005;57(3):605-10.
2005: Takahisa Imamura; Sumio Tanase; Grzegorz Szmyd; Andrzej Kozik; James Travis; Jan Potempa
Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus.
The Journal of experimental medicine 2005;201(10):1669-76.
2005: Salunya tancharoen; Krishna Pada Sarker; Takahisa Imamura; Kamal Krishna Biswas; Kenji Matsushita; Syouko Tatsuyama; James Travis; Jan Potempa; Mitsuo Torii; Ikuro Maruyama
Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5796-804.
2005: Renata Filipek; Jan Potempa; Matthias Bochtler
A comparison of staphostatin B with standard mechanism serine protease inhibitors.
The Journal of biological chemistry 2005;280(15):14669-74.
2005: Shaun M Sheets; Jan Potempa; James Travis; Carlos A Casiano; Hansel M Fletcher
Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells.
Infection and immunity 2005;73(3):1543-52.
2005: Renata Mezyk-Kopec; Malgorzata Bzowska; Jan Potempa; Malgorzata Bzowska; Natalia Jura; Aneta Sroka; Roy A Black; Joanna Bereta
Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis.
Infection and immunity 2005;73(3):1506-14.
2005: Lindsey N Shaw; Ewa Golonka; Grzegorz Szmyd; Simon J Foster; James Travis; Jan Potempa
Cytoplasmic control of premature activation of a secreted protease zymogen: deletion of staphostatin B (SspC) in Staphylococcus aureus 8325-4 yields a profound pleiotropic phenotype.
Journal of bacteriology 2005;187(5):1751-62.
2005: Magdalena Kawalec; Jan Potempa; Jonathan Moon; James Travis; Barbara E Murray
Molecular diversity of a putative virulence factor: purification and characterization of isoforms of an extracellular serine glutamyl endopeptidase of Enterococcus faecalis with different enzymatic activities.
Journal of bacteriology 2005;187(1):266-75.
2005: Jan Potempa; Robert N Pike
Bacterial peptidases.
Contributions to microbiology 2005;12():132-80.
2004: Magdalena Sieprawska-Lupa; Piotr M Mydel; Katarzyna Krawczyk; Katarzyna Wójcik; Magdalena Puklo; Boguslaw Lupa; Piotr Suder; Jerzy Silberring; Matthew Reed; jan pohl; William M Shafer; Fionnuala McAleese; Timothy Foster; James Travis; Jan Potempa
Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases.
Antimicrobial agents and chemotherapy 2004;48(12):4673-9.
2004: Maryta Sztukowska; Aneta Sroka; Marcin Bugno; Agnieszka Banbula; Yusuke Takahashi; Robert N Pike; Caroline Attardo Genco; James Travis; Jan Potempa
The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities.
Molecular microbiology 2004;54(5):1393-408.
2004: Renata Filipek; Roman H Szczepanowski; Artur Sabat; Jan Potempa; Matthias Bochtler
Prostaphopain B structure: a comparison of proregion-mediated and staphostatin-mediated protease inhibition.
Biochemistry 2004;43(44):14306-15.
2004: Ewa Golonka; Renata Filipek; Artur Sabat; Anna Sinczak; Jan Potempa
Genetic characterization of staphopain genes in Staphylococcus aureus.
Biological chemistry 2004;385(11):1059-67.
2004: Xinyan Liu; Aneta Sroka; Jan Potempa; Caroline Attardo Genco
Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR.
Biological chemistry 2004;385(11):1049-57.
2004: Takahisa Imamura; Jan Potempa; James Travis
Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases.
Biological chemistry 2004;385(11):989-96.
2004: Grzegorz Dubin; Justyna Stec-Niemczyk; Tomasz Dylag; Jerzy Silberring; Adam Dubin; Jan Potempa
Characterisation of a highly specific, endogenous inhibitor of cysteine protease from Staphylococcus epidermidis, a new member of the staphostatin family.
Biological chemistry 2004;385(6):543-6.
2004: Aneta Oleksy; Ewa Golonka; Agnieszka Bańbuła; Grzegorz Szmyd; Jonathan Moon; Malgorzata Kubica; Doron Greenbaum; Matthew Bogyo; Timothy J Foster; James Travis; Jan Potempa
Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis.
Biological chemistry 2004;385(6):525-35.
2004: Raquel García-Castellanos; Goretti Mallorquí-Fernández; Aniebrys Marrero; Jan Potempa; Miquel Coll; F Xavier Gomis-Rüth
On the transcriptional regulation of methicillin resistance: MecI repressor in complex with its operator.
The Journal of biological chemistry 2004;279(17):17888-96.
2004: Ozlem Dogan Ekici; Marion G Götz; Karen Ellis James; Zhao Zhao Li; Brian J Rukamp; Juliana L Asgian; Conor R Caffrey; Elizabeth Hansell; Jan Dvorák; James H McKerrow; Jan Potempa; James Travis; Jowita Mikolajczyk; Guy S Salvesen; James C Powers
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.
Journal of medicinal chemistry 2004;47(8):1889-92.
2004: Grzegorz Dubin; Grzegorz M Popowicz; Marcin Krajewski; Jan Potempa; Adam Dubin; Tad A Holak
1H, 15N and 13C NMR resonance assignments of staphostatin A, a specific Staphylococcus aureus cysteine proteinase inhibitor.
Journal of biomolecular NMR 2004;28(3):295-6.
2004: Lindsey Shaw; Ewa Golonka; Jan Potempa; Simon J Foster
The role and regulation of the extracellular proteases of Staphylococcus aureus.
Microbiology (Reading, England) 2004;150(Pt 1):217-28.
2003: Takahisa Imamura; James Travis; Jan Potempa
The biphasic virulence activities of gingipains: activation and inactivation of host proteins.
Current protein & peptide science 2003;4(6):443-50.
2003: Jan Potempa; Aneta Sroka; Takahisa Imamura; James Travis
Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes.
Current protein & peptide science 2003;4(6):397-407.
2003: Grzegorz Dubin; Marcin Krajewski; Grzegorz M Popowicz; Justyna Stec-Niemczyk; Matthias Bochtler; Jan Potempa; Adam Dubin; Tad A Holak
A novel class of cysteine protease inhibitors: solution structure of staphostatin A from Staphylococcus aureus.
Biochemistry 2003;42(46):13449-56.
2003: Renata Filipek; Malgorzata Rzychon; Aneta Oleksy; Milosz Gruca; Adam Dubin; Jan Potempa; Matthias Bochtler
The Staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease.
The Journal of biological chemistry 2003;278(42):40959-66.
2003: Nafisa Ally; James C Whisstock; Magdalena Sieprawska-Lupa; Jan Potempa; Bernard F Le Bonniec; James Travis; Robert N Pike
Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes.
Biochemistry 2003;42(40):11693-700.
2003: Raquel García-Castellanos; Aniebrys Marrero; Goretti Mallorquí-Fernández; Jan Potempa; Miquel Coll; F Xavier Gomis-Ruth
Three-dimensional structure of MecI. Molecular basis for transcriptional regulation of staphylococcal methicillin resistance.
The Journal of biological chemistry 2003;278(41):39897-905.
2003: Hiroyuki Tada; Shunji Sugawara; Eiji Nemoto; Takahisa Imamura; Jan Potempa; James Travis; Hidetoshi Shimauchi; Haruhiko Takada
Proteolysis of ICAM-1 on human oral epithelial cells by gingipains.
Journal of dental research 2003;82(10):796-801.
2003: Malgorzata Rzychon; Renata Filipek; Artur Sabat; Klaudia Kosowska; Adam Dubin; Jan Potempa; Matthias Bochtler
Staphostatins resemble lipocalins, not cystatins in fold.
Protein science : a publication of the Protein Society 2003;12(10):2252-6.
2003: Malgorzata Rzychon; Artur Sabat; Klaudia Kosowska; Jan Potempa; Adam Dubin
Staphostatins: an expanding new group of proteinase inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases.
Molecular microbiology 2003;49(4):1051-66.
2003: Robert Dulinski; Piotr Suder; Ibeth Guevara-Lora; Maria Rapała-Kozik; Jan Potempa; Jerzy Silberring; Takahisa Imamura; James Travis; Andrzej Kozik
Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins.
Biological chemistry 2003;384(6):929-37.
2003: Artur Sabat; Jolanta Krzyszton-Russjan; Wojciech Strzalka; Renata Filipek; Klaudia Kosowska; Waleria Hryniewicz; James Travis; Jan Potempa
New method for typing Staphylococcus aureus strains: multiple-locus variable-number tandem repeat analysis of polymorphism and genetic relationships of clinical isolates.
Journal of clinical microbiology 2003;41(4):1801-4.
2003: Jowita Mikolajczyk; Kelly M Boatright; Henning Stennicke; Tamim Nazif; Jan Potempa; Matthew Bogyo; Guy S Salvesen
Sequential autolytic processing activates the zymogen of Arg-gingipain.
The Journal of biological chemistry 2003;278(12):10458-64.
2002: Joanna Cichy; Robert Bals; Jan Potempa; Anne Mani; Ellen Puré
Proteinase-mediated release of epithelial cell-associated CD44. Extracellular CD44 complexes with components of cellular matrices.
The Journal of biological chemistry 2002;277(46):44440-7.
2002: Joel A Krauser; Jan Potempa; James Travis; James C Powers
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency.
Biological chemistry 2002;383(7-8):1193-8.
2002: Takahisa Imamura; Sumio Tanase; Izumi Hayashi; Jan Potempa; Andrzej Kozik; James Travis
Release of a new vascular permeability enhancing peptide from kininogens by human neutrophil elastase.
Biochemical and biophysical research communications 2002;294(2):423-8.
2002: Hiroyuki Tada; Shunji Sugawara; Eiji Nemoto; Nobuhiro Takahashi; Takahisa Imamura; Jan Potempa; James Travis; Hidetoshi Shimauchi; Haruhiko Takada
Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production.
Infection and immunity 2002;70(6):3304-7.
2002: Jannet Katz; Qiu-Bo Yang; Ping Zhang; Jan Potempa; James Travis; Suzanne M Michalek; Daniel F Balkovetz
Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains.
Infection and immunity 2002;70(5):2512-8.
2002: Klaudia Kosowska; Jesper Reinholdt; Lone K Rasmussen; Artur Sabat; Jan Potempa; Mogens Kilian; Knud Poulsen
The Clostridium ramosum IgA proteinase represents a novel type of metalloendopeptidase.
The Journal of biological chemistry 2002;277(14):11987-94.
2002: Aneta Oleksy; Agnieszka Banbula; Marcin Bugno; James Travis; Jan Potempa
Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activation.
Microbial pathogenesis 2002;32(4):173-81.
2002: Maryta Sztukowska; Marcin Bugno; Jan Potempa; James Travis; Donald M Kurtz
Role of rubrerythrin in the oxidative stress response of Porphyromonas gingivalis.
Molecular microbiology 2002;44(2):479-88.
2001: Takahisa Imamura; K Matsushita; James Travis; Jan Potempa
Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues.
Antimicrobial agents and chemotherapy 2001;45(10):2871-6.
2001: Aneta Sroka; Maryta Sztukowska; Jan Potempa; James Travis; Caroline Attardo Genco
Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis.
Journal of bacteriology 2001;183(19):5609-16.
2001: Agnieszka Banbula; Pawel Mak; Marek Smoluch; James Travis; Jan Potempa
Arginine-specific cysteine proteinase from porphyromonas gingivalis as a convenient tool in protein chemistry.
Biological chemistry 2001;382(9):1399-404.
2001: Fionnuala McAleese; Evelyn J Walsh; M Sieprawska; Jan Potempa; Timothy J Foster
Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease.
The Journal of biological chemistry 2001;276(32):29969-78.
2001: A Lourbakos; Jan Potempa; James Travis; M R D'Andrea; Patricia Andrade-Gordon; Rosemary J Santulli; Eleanor J Mackie; Robert N Pike
Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion.
Infection and immunity 2001;69(8):5121-30.
2001: T Nakagawa; T Sims; Q Fan; Jan Potempa; J Travis; Laura S Houston; Roy C Page
Functional characteristics of antibodies induced by Arg-gingipain (HRgpA) and Lys-gingipain (Kgp) from Porphyromonas gingivalis.
Oral microbiology and immunology 2001;16(4):202-11.
2001: Scott J Snipas; Henning Stennicke; Stefan J Riedl; Jan Potempa; J Travis; A J Barrett; Guy S Salvesen
Inhibition of distant caspase homologues by natural caspase inhibitors.
The Biochemical journal 2001;357(Pt 2):575-80.
2001: A Lourbakos; Y P Yuan; AL Jenkins; James Travis; Patricia Andrade-Gordon; Rosemary J Santulli; Jan Potempa; Robert N Pike
Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity.
Blood 2001;97(12):3790-7.
2001: Takahisa Imamura; A Banbula; P J Pereira; James Travis; Jan Potempa
Activation of human prothrombin by arginine-specific cysteine proteinases (Gingipains R) from porphyromonas gingivalis.
The Journal of biological chemistry 2001;276(22):18984-91.
2001: Agnieszka Banbula; J Yen; Aneta Oleksy; Pawel Mak; Marcin Bugno; James Travis; Jan Potempa
Porphyromonas gingivalis DPP-7 represents a novel type of dipeptidylpeptidase.
The Journal of biological chemistry 2001;276(9):6299-305.
2001: Heloisa Gusman; James Travis; Eva J Helmerhorst; Jan Potempa; Robert F Troxler; Frank G Oppenheim
Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.
Infection and immunity 2001;69(3):1402-8.
2001: Israel Rubinstein; Jan Potempa; J Travis; Xiao-Pei Gao
Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo.
Infection and immunity 2001;69(2):1199-201.
2001: Takahisa Imamura; Sumio Tanase; T Hamamoto; Jan Potempa; James Travis
Activation of blood coagulation factor IX by gingipains R, arginine-specific cysteine proteinases from Porphyromonas gingivalis.
The Biochemical journal 2001;353(Pt 2):325-31.
2001: Daniel Nelson; Jason Goldstein; K Boatright; Derek W S Harty; Simon L Cook; P J Hickman; Jan Potempa; James Travis; John A Mayo
pH-regulated secretion of a glyceraldehyde-3-phosphate dehydrogenase from Streptococcus gordonii FSS2: purification, characterization, and cloning of the gene encoding this enzyme.
Journal of dental research 2001;80(1):371-7.
2000: Jan Potempa; Agnieszka Banbula; James Travis
Role of bacterial proteinases in matrix destruction and modulation of host responses.
Periodontology 2000 2000;24():153-92.
2000: Takahisa Imamura; Jan Potempa; James Travis
Comparison of pathogenic properties between two types of arginine-specific cysteine proteinases (gingipains-R) from Porphyromonas gingivalis.
Microbial pathogenesis 2000;29(3):155-63.
2000: James Travis; Jan Potempa
Bacterial proteinases as targets for the development of second-generation antibiotics.
Biochimica et biophysica acta 2000;1477(1-2):35-50.
2000: Agnieszka Banbula; Marcin Bugno; Jason Goldstein; J Yen; Daniel Nelson; James Travis; Jan Potempa
Emerging family of proline-specific peptidases of Porphyromonas gingivalis: purification and characterization of serine dipeptidyl peptidase, a structural and functional homologue of mammalian prolyl dipeptidyl peptidase IV.
Infection and immunity 2000;68(3):1176-82.
2000: H Abaibou; Q Ma; G Jon Olango; Jan Potempa; James Travis; Hansel M Fletcher
Unaltered expression of the major protease genes in a non-virulent recA-defective mutant of Porphyromonas gingivalis W83.
Oral microbiology and immunology 2000;15(1):40-7.
2000: Artur Sabat; Klaudia Kosowska; Knud Poulsen; Andrzej Kasprowicz; A Sekowska; B van Den Burg; James Travis; Jan Potempa
Two allelic forms of the aureolysin gene (aur) within Staphylococcus aureus.
Infection and immunity 2000;68(2):973-6.
2000: J Travis; A Banbula; Jan Potempa
The role of bacterial and host proteinases in periodontal disease.
Advances in experimental medicine and biology 2000;477():455-65.
1999: Michael A Curtis; Howard Kuramitsu; M Lantz; F L Macrina; K Nakayama; Jan Potempa; E C Reynolds; Joseph Aduse-Opoku
Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis.
Journal of periodontal research 1999;34(8):464-72.
1999: A Eichinger; Hans-Georg Beisel; Uwe Jacob; Robert Huber; FJ Medrano; Agnieszka Banbula; Jan Potempa; James Travis; Wolfram Bode
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
The EMBO journal 1999;18(20):5453-62.
1999: Maria Rapala-Kozik; Jan Potempa; Daniel Nelson; Andrzej Kozik; James Travis
Comparative cleavage sites within the reactive-site loop of native and oxidized alpha1-proteinase inhibitor by selected bacterial proteinases.
Biological chemistry 1999;380(10):1211-6.
1999: Waltena Simpson; C Y Wang; J Mikolajczyk-Pawlinska; Jan Potempa; James Travis; Vincent Craig Bond; Caroline Attardo Genco
Transposition of the endogenous insertion sequence element IS1126 modulates gingipain expression in Porphyromonas gingivalis.
Infection and immunity 1999;67(10):5012-20.
1999: Agnieszka Banbula; Marcin Bugno; A Kuster; P C Heinrich; James Travis; Jan Potempa
Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalis.
Biochemical and biophysical research communications 1999;261(3):598-602.
1999: W T McGraw; Jan Potempa; D Farley; James Travis
Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase.
Infection and immunity 1999;67(7):3248-56.
1999: MJ Janusz; M Hare; SL Durham; Jan Potempa; W McGraw; R Pike; J Travis; S D Shapiro
Cartilage proteoglycan degradation by a mouse transformed macrophage cell line is mediated by macrophage metalloelastase.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48(5):280-8.
1999: Daniel Nelson; Jan Potempa; Tomasz Kordula; James Travis
Purification and characterization of a novel cysteine proteinase (periodontain) from Porphyromonas gingivalis. Evidence for a role in the inactivation of human alpha1-proteinase inhibitor.
The Journal of biological chemistry 1999;274(18):12245-51.
1999: Agnieszka Banbula; Pawel Mak; Marcin Bugno; Jerzy Silberring; Adam Dubin; Daniel Nelson; James Travis; Jan Potempa
Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis.
The Journal of biological chemistry 1999;274(14):9246-52.
1999: Caroline Attardo Genco; Jan Potempa; J Mikolajczyk-Pawlinska; James Travis
Role of gingipains R in the pathogenesis of Porphyromonas gingivalis-mediated periodontal disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1999;28(3):456-65.
1999: K Hosotaki; Takahisa Imamura; Jan Potempa; N Kitamura; James Travis
Activation of protein C by arginine-specific cysteine proteinases (gingipains-R) from Porphyromonas gingivalis.
Biological chemistry 1999;380(1):75-80.
1998: Andrzej Kozik; R B Moore; Jan Potempa; Takahisa Imamura; Maria Rapala-Kozik; James Travis
A novel mechanism for bradykinin production at inflammatory sites. Diverse effects of a mixture of neutrophil elastase and mast cell tryptase versus tissue and plasma kallikreins on native and oxidized kininogens.
The Journal of biological chemistry 1998;273(50):33224-9.
1998: J Mikolajczyk-Pawlinska; James Travis; Jan Potempa
Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: implications for pathogenicity of periodontal disease.
FEBS letters 1998;440(3):282-6.
1998: Agnieszka Banbula; Jan Potempa; James Travis; C Fernandez-Catalán; K Mann; Robert Huber; Wolfram Bode; FJ Medrano
Amino-acid sequence and three-dimensional structure of the Staphylococcus aureus metalloproteinase at 1.72 A resolution.
Structure (London, England : 1993) 1998;6(9):1185-93.
1998: A Lourbakos; Carla Chinni; P Thompson; Jan Potempa; James Travis; Eleanor J Mackie; Robert N Pike
Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis.
FEBS letters 1998;435(1):45-8.
1998: Caroline Attardo Genco; B M Odusanya; Jan Potempa; J Mikolajczyk-Pawlinska; James Travis
A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice.
Infection and immunity 1998;66(9):4108-14.
1998: Jan Potempa; J Mikolajczyk-Pawlinska; D Brassell; Daniel Nelson; Ida B Thøgersen; Jan J Enghild; James Travis
Comparative properties of two cysteine proteinases (gingipains R), the products of two related but individual genes of Porphyromonas gingivalis.
The Journal of biological chemistry 1998;273(34):21648-57.
1998: Jason M Mailhot; Jan Potempa; SH Stein; J Travis; John D Sterrett; Philip J Hanes; Carl M Russell
A relationship between proteinase activity and clinical parameters in the treatment of periodontal disease.
Journal of clinical periodontology 1998;25(7):578-84.
1998: Daniel Nelson; Jan Potempa; James Travis
Inactivation of alpha1-proteinase inhibitor as a broad screen for detecting proteolytic activities in unknown samples.
Analytical biochemistry 1998;260(2):230-6.
1998: Andrzej Kozik; Jan Potempa; James Travis
Spontaneous inactivation of human lung tryptase as probed by size-exclusion chromatography and chemical cross-linking: dissociation of active tetrameric enzyme into inactive monomers is the primary event of the entire process.
Biochimica et biophysica acta 1998;1385(1):139-48.
1998: Agnieszka Banbula; Jan Potempa; James Travis; Wolfram Bode; FJ Medrano
Crystallization and preliminary X-ray diffraction analysis of gingipain R2 from Porphyromonas gingivalis in complex with H-D-Phe-Phe-Arg-chloromethylketone.
Protein science : a publication of the Protein Society 1998;7(5):1259-61.
1998: C C Calkins; K Platt; Jan Potempa; James Travis
Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion.
The Journal of biological chemistry 1998;273(12):6611-4.
1998: DA Bagarozzi; Jan Potempa; James Travis
Purification and characterization of an arginine-specific peptidase from ragweed (Ambrosia artemisiifolia) pollen.
American journal of respiratory cell and molecular biology 1998;18(3):363-9.
1998: J Mikolajczyk-Pawlinska; Tomasz Kordula; N Pavloff; P A Pemberton; W C Chen; James Travis; Jan Potempa
Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity.
Biological chemistry 1998;379(2):205-11.
1997: Joanna Cichy; S Rose-John; Jan Potempa; Juliusz Pryjma; James Travis
Oncostatin M stimulates the expression and release of the IL-6 receptor in human hepatoma HepG2 cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5648-53.
1997: Magnus Abrahamson; M Wikström; Jan Potempa; S Renvert; A Hall
Modification of cystatin C activity by bacterial proteinases and neutrophil elastase in periodontitis.
Molecular pathology : MP 1997;50(6):291-7.
1997: Robert N Pike; Jan Potempa; Richard Skinner; Hazel L Fitton; W T McGraw; J Travis; M Owen; L Jin; Robin W Carrell
Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity.
The Journal of biological chemistry 1997;272(32):19652-5.
1997: T Imamura; Jan Potempa; S Tanase; James Travis
Activation of blood coagulation factor X by arginine-specific cysteine proteinases (gingipain-Rs) from Porphyromonas gingivalis.
The Journal of biological chemistry 1997;272(25):16062-7.
1997: Joanna Cichy; Jan Potempa; James Travis
Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells.
The Journal of biological chemistry 1997;272(13):8250-5.
1997: Jan Potempa; R Pike; James Travis
Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes.
Biological chemistry 1997;378(3-4):223-30.
1997: N Pavloff; P A Pemberton; Jan Potempa; W C Chen; R N Pike; V Prochazka; MC Kiefer; James Travis; P J Barr
Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases.
The Journal of biological chemistry 1997;272(3):1595-600.
1997: H Grøn; R Pike; Jan Potempa; James Travis; Ida B Thøgersen; Jan J Enghild; Salvatore V Pizzo
The potential role of alpha 2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis.
Journal of periodontal research 1997;32(1 Pt 1):61-8.
1997: James Travis; R Pike; T Imamura; Jan Potempa
Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis.
Journal of periodontal research 1997;32(1 Pt 2):120-5.
1996: H Koloczek; Agnieszka Banbula; G S Salvesen; Jan Potempa
Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy.
Protein science : a publication of the Protein Society 1996;5(11):2226-35.
1996: D A Bagarozzi; Robert N Pike; Jan Potempa; James Travis
Purification and characterization of a novel endopeptidase in ragweed (Ambrosia artemisiifolia) pollen.
The Journal of biological chemistry 1996;271(42):26227-32.
1996: P Hof; I Mayr; Robert Huber; E Korzus; Jan Potempa; James Travis; James C Powers; Wolfram Bode
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities.
The EMBO journal 1996;15(20):5481-91.
1996: MA Jagels; J Travis; Jan Potempa; R Pike; TE Hugli
Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis.
Infection and immunity 1996;64(6):1984-91.
1996: Robert N Pike; Jan Potempa; W McGraw; Theresa H T Coetzer; James Travis
Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis.
Journal of bacteriology 1996;178(10):2876-82.
1996: Richard G DiScipio; PJ Daffern; M Kawahara; R Pike; J Travis; TE Hugli; Jan Potempa
Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas (Bacteroides) gingivalis. Prior oxidation of C5 augments proteinase digestion of C5.
Immunology 1996;87(4):660-7.
1996: Jan Potempa; James Travis
Porphyromonas gingivalis proteinases in periodontitis, a review.
Acta biochimica Polonica 1996;43(3):455-65.
1996: MA Jagels; JA Ember; J Travis; Jan Potempa; R Pike; TE Hugli
Cleavage of the human C5A receptor by proteinases derived from Porphyromonas gingivalis: cleavage of leukocyte C5a receptor.
Advances in experimental medicine and biology 1996;389():155-64.
1995: T Imamura; Jan Potempa; R N Pike; James N Moore; M H Barton; J Travis
Effect of free and vesicle-bound cysteine proteinases of Porphyromonas gingivalis on plasma clot formation: implications for bleeding tendency at periodontitis sites.
Infection and immunity 1995;63(12):4877-82.
1995: Jan Potempa; N Pavloff; James Travis
Porphyromonas gingivalis: a proteinase/gene accounting audit.
Trends in microbiology 1995;3(11):430-4.
1995: J Travis; Jan Potempa; H Maeda
Are bacterial proteinases pathogenic factors?
Trends in microbiology 1995;3(10):405-7.
1995: Joanna Cichy; Jan Potempa; R K Chawla; James Travis
Stimulatory effect of inflammatory cytokines on alpha 1-antichymotrypsin expression in human lung-derived epithelial cells.
The Journal of clinical investigation 1995;95(6):2729-33.
1995: T Imamura; Jan Potempa; Robert N Pike; James Travis
Dependence of vascular permeability enhancement on cysteine proteinases in vesicles of Porphyromonas gingivalis.
Infection and immunity 1995;63(5):1999-2003.
1995: Jan Potempa; R Pike; James Travis
The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain.
Infection and immunity 1995;63(4):1176-82.
1995: Joanna Cichy; Jan Potempa; James Travis
Effect of dexamethasone on alpha 1-proteinase inhibitor synthesis in human cells of monocytic origin.
Biochemical and biophysical research communications 1995;208(1):216-22.
1995: Jan Potempa; Jan J Enghild; James Travis
The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin.
The Biochemical journal 1995;306 ( Pt 1)():191-7.
1995: Joanna Cichy; Jan Potempa; R K Chawla; James Travis
Regulation of alpha 1-antichymotrypsin synthesis in cells of epithelial origin.
FEBS letters 1995;359(2-3):262-6.
1995: N Pavloff; Jan Potempa; R N Pike; V Prochazka; M C Kiefer; James Travis; P J Barr
Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein.
The Journal of biological chemistry 1995;270(3):1007-10.
1995: Ludmila Prokesová; B Potuzníkovà; Jan Potempa; J Zikán; J Radl; Z Porwit-Bóbr; C John
Cleavage of human immunoglobulins by proteinase from Staphylococcus aureus.
Advances in experimental medicine and biology 1995;371A():613-6.
1994: James Travis; Robert N Pike; T Imamura; Jan Potempa
The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease.
American journal of respiratory and critical care medicine 1994;150(6 Pt 2):S143-6.
1994: T Imamura; Robert N Pike; Jan Potempa; James Travis
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.
The Journal of clinical investigation 1994;94(1):361-7.
1994: Jan Potempa; E Korzus; James Travis
The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
The Journal of biological chemistry 1994;269(23):15957-60.
1994: A Dubin; Jan Potempa; James Travis
Structural and functional characterization of elastases from horse neutrophils.
The Biochemical journal 1994;300 ( Pt 2)():401-6.
1994: Aleksander Koj; A Guzdek; Jan Potempa; E Korzus; James Travis
Origin of circulating acute phase cytokines: modified proteins may trigger IL-6 production by macrophages. Preliminary report.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1994;45(1):69-80.
1994: Robert N Pike; W McGraw; Jan Potempa; James Travis
Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins.
The Journal of biological chemistry 1994;269(1):406-11.
1994: M Wikström; Jan Potempa; A Polanowski; James Travis; S Renvert
Detection of Porphyromonas gingivalis in gingival exudate by a dipeptide-enhanced trypsin-like activity.
Journal of periodontology 1994;65(1):47-55.
1992: J A Wingrove; R G DiScipio; Z Chen; Jan Potempa; J Travis; T E Hugli
Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis.
The Journal of biological chemistry 1992;267(26):18902-7.
1992: Z Chen; Jan Potempa; A Polanowski; M Wikstrom; James Travis
Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis.
The Journal of biological chemistry 1992;267(26):18896-901.
1992: U Baumann; Wolfram Bode; Robert Huber; James Travis; Jan Potempa
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution.
Journal of molecular biology 1992;226(4):1207-18.
1992: A Dubin; James Travis; Jan J Enghild; Jan Potempa
Equine leukocyte elastase inhibitor. Primary structure and identification as a thymosin-binding protein.
The Journal of biological chemistry 1992;267(10):6576-83.
1992: Ludmila Prokesová; B Potuzníková; Jan Potempa; J Zikán; J Radl; L Hachová; K Baran; Z Porwit-Bobr; C John
Cleavage of human immunoglobulins by serine proteinase from Staphylococcus aureus.
Immunology letters 1992;31(3):259-65.
1991: Jan Potempa; D Fedak; A Dubin; A Mast; James Travis
Proteolytic inactivation of alpha-1-anti-chymotrypsin. Sites of cleavage and generation of chemotactic activity.
The Journal of biological chemistry 1991;266(32):21482-7.
1991: Z X Chen; Jan Potempa; A Polanowski; S Renvert; M Wikström; James Travis
Stimulation of proteinase and amidase activities in Porphyromonas (Bacteroides) gingivalis by amino acids and dipeptides.
Infection and immunity 1991;59(8):2846-50.
1991: B J Darien; Jan Potempa; James N Moore; J Travis
Antithrombin III activity in horses with colic: an analysis of 46 cases.
Equine veterinary journal 1991;23(3):211-4.
1991: H Kołoczek; A Waśniowska; Jan Potempa; Zygmunt Wasylewski
The fluorescence quenching resolved spectra and red-edge excitation fluorescence measurements of human alpha 1-proteinase inhibitor.
Biochimica et biophysica acta 1991;1073(3):619-25.
1991: Ludmila Prokesová; Z Porwit-Bóbr; K Baran; Jan Potempa; Miloslav Pospísil; C John
Effect of metalloproteinase from Staphylococcus aureus on in vitro stimulation of human lymphocytes.
Immunology letters 1991;27(3):225-30.
1991: Jan Potempa; J K Wunderlich; James Travis
Comparative properties of three functionally different but structurally related serpin variants from horse plasma.
The Biochemical journal 1991;274 ( Pt 2)():465-71.
1991: James Travis; A Dubin; Jan Potempa; W Watorek; A Kurdowska
Neutrophil proteinases. Caution signs in designing inhibitors against enzymes with possible multiple functions.
Annals of the New York Academy of Sciences 1991;624():81-6.
1991: E Korzus; A Dubin; Jan Potempa; James Travis
Elastase inhibitor from mammalian neutrophil cytosol.
Biomedica biochimica acta 1991;50(4-6):687-90.
1990: A Guzdek; Jan Potempa; A Dubin; James Travis
Comparative properties of human alpha-1-proteinase inhibitor glycosylation variants.
FEBS letters 1990;272(1-2):125-7.
1990: J Travis; A Guzdek; Jan Potempa; W Watorek
Serpins: structure and mechanism of action.
Biological chemistry Hoppe-Seyler 1990;371 Suppl():3-11.
1990: A Dubin; Jan Potempa; James Travis
Isolation of nine human plasma proteinase inhibitors by sequential affinity chromatography.
Preparative biochemistry 1990;20(1):63-74.
1989: Jan Potempa; Z Porwit-Bobr; James Travis
Stabilization vs. degradation of Staphylococcus aureus metalloproteinase.
Biochimica et biophysica acta 1989;993(2-3):301-4.
1989: K Baran; M Górka; Jan Potempa; Z Porwit-Bóbr
Chemoattractant activity of Staphylococcus aureus serine proteinase modified human plasma alpha-1-proteinase inhibitor.
Antonie van Leeuwenhoek 1989;56(4):361-5.
1989: Jan Potempa; K Kwon; R Chawla; James Travis
Inter-alpha-trypsin inhibitor. Inhibition spectrum of native and derived forms.
The Journal of biological chemistry 1989;264(25):15109-14.
1989: B H Shieh; Jan Potempa; James Travis
The use of alpha 2-antiplasmin as a model for the demonstration of complex reversibility in serpins.
The Journal of biological chemistry 1989;264(23):13420-3.
1989: Z Porwit-Bobr; T Ochalek; L Prokesova; C John; K Baran; Jan Potempa
Effects of serine proteinase from Staphylococcus aureus V8 cells on Con A stimulation of human lymphocytes.
Microbiologica 1989;12(2):139-42.
1989: B J Darien; Jan Potempa; James N Moore; J Travis
Antithrombin III activity (residual thrombin activity) in plasma from non-medicated or heparinized horses.
Veterinary research communications 1989;13(1):31-46.
1988: James Travis; B H Shieh; Jan Potempa
The functional role of acute phase plasma proteinase inhibitors.
The Tokai journal of experimental and clinical medicine 1988;13(6):313-20.
1988: Ludmila Prokesová; Z Porwit-Bóbr; K Baran; Jan Potempa; C John
Effect of serine proteinase from Staphylococcus aureus on in vitro stimulation of human lymphocytes.
Immunology letters 1988;19(2):127-32.
1988: Jan Potempa; B H Shieh; James Travis
Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites.
Science (New York, N.Y.) 1988;241(4866):699-700.
1988: Jan Potempa; A Dubin; W Watorek; James Travis
An elastase inhibitor from equine leukocyte cytosol belongs to the serpin superfamily. Further characterization and amino acid sequence of the reactive center.
The Journal of biological chemistry 1988;263(15):7364-9.
1988: Jan Potempa; A Dubin; G Korzus; James Travis
Degradation of elastin by a cysteine proteinase from Staphylococcus aureus.
The Journal of biological chemistry 1988;263(6):2664-7.
1988: Jan Potempa; E Korzus; J Silberring; A Dubin
Noncatalytic protein component of elastase from horse leucocytes. A protein with regulatory function.
The International journal of biochemistry 1988;20(1):105-8.
1986: Jan Potempa; W Watorek; J Travis
The inactivation of human plasma alpha 1-proteinase inhibitor by proteinases from Staphylococcus aureus.
The Journal of biological chemistry 1986;261(30):14330-4.
1986: Zygmunt Wasylewski; W Stryjewski; A Waśniowska; Jan Potempa; K Baran
Effect of calcium binding on conformational changes of staphylococcal metalloproteinase measured by means of intrinsic protein fluorescence.
Biochimica et biophysica acta 1986;871(2):177-81.
1986: A Dubin; Jan Potempa; H P Schnebli; Aleksander Koj
Comparison of specificity of human and horse leucocyte proteinases with synthetic peptide substrates.
Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 1986;24(2):157-61.
1986: Jan Potempa; E Korzus; A Dubin; J Silberring
Elastinolytic activity of horse leukocyte proteinases. Comparison with elastases from human leukocytes and porcine pancreas.
Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 1986;24(2):149-56.
1986: A Dubin; Jan Potempa; Bohdan Turyna
The interaction between some serine proteinases and horse leucocyte inhibitor.
Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 1986;24(2):163-8.
1986: A Dubin; Jan Potempa; A Kurdowska; W Pajdak; Aleksander Koj
Comparison of antiproteolytic activities of alpha-1-proteinase inhibitors from the plasma of some mammalian species.
Comparative biochemistry and physiology. B, Comparative biochemistry 1986;83(2):375-80.
1985: Jan Potempa; A Dubin; U Seemüller; H P Schnebli; Aleksander Koj
Inhibition of horse leucocyte proteinases by eglin, a proteinase inhibitor from leeches.
Biomedica biochimica acta 1985;44(2):335-9.
1985: Jan Potempa; A Dubin
[Evolution of the structure and function of serine proteolytic enzymes].
Postepy biochemii 1985;31(3-4):531-54.
1985: A Dubin; Jan Potempa; J Silberring
Horse leucocyte proteinase-inhibitor system. Kinetic parameters of the inhibition reaction.
The International journal of biochemistry 1985;17(4):509-13.
1984: A Dubin; Jan Potempa; J Silberring
Alpha 2-macroglobulin from horse plasma. Purification, properties and interaction with certain serine proteinases.
Biochemistry international 1984;8(4):589-96.
1982: Jan Potempa
Cibacron Blue-induced modification of neutral proteinase from horse blood leukocytes.
Acta biologica et medica Germanica 1982;41(1):47-52.
1982: Jan Potempa
Isolation and properties of an elastase-like proteinase from horse blood leucocytes.
Folia histochemica et cytochemica 1982;20(1-2):41-52.