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Grietje Molema

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Federico Iovino; Grietje Molema; Diederik van de Beek; Matthijs C Brouwer; Jetta J E Bijlsma
Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease.
Neng F Kurniati; Grietje Molema; Jill Moser; Michel M R F Struys; Matijs van Meurs; Franziska Vom Hagen; Johanna Westra; Jan G Zijlstra; Peter J Zwiers; Hans-Peter Hammes; Rianne M Jongman; Peter Heeringa
Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury.
J M Kułdo; Grietje Molema; K I Ogawara; Marianne G Rots; J A C Schalk; C Trautwein; P J Zwiers; Sigridur A Asgeirsdóttir; B Banas; Anna Rita Bellu; Hidde J Haisma; Jan A A M Kamps
Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo.

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2013: Federico Iovino; Grietje Molema; Diederik van de Beek; Matthijs C Brouwer; Jetta J E Bijlsma
Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease.
Cellular microbiology 2013;15(6):870-81.
2013: Neng F Kurniati; Grietje Molema; Jill Moser; Michel M R F Struys; Matijs van Meurs; Franziska Vom Hagen; Johanna Westra; Jan G Zijlstra; Peter J Zwiers; Hans-Peter Hammes; Rianne M Jongman; Peter Heeringa
Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013;28(3):567-75.
2013: J M Kułdo; Grietje Molema; K I Ogawara; Marianne G Rots; J A C Schalk; C Trautwein; P J Zwiers; Sigridur A Asgeirsdóttir; B Banas; Anna Rita Bellu; Hidde J Haisma; Jan A A M Kamps
Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo.
Journal of controlled release : official journal of the Controlled Release Society 2013;166(1):57-65.
2012: Lothar C Dieterich; Irina Alafuzoff; Hellmut G Augustin; Per-Henrik D Edqvist; Patrik Georgii-Hemming; Hua Huang; Theo Kraus; Elise Langenkamp; Erik Larsson; Sofie Mellberg; Grietje Molema; Tommie Olofsson; Fredrik Pontén; Henriikka Salomäki; Ola Söderberg; Martin Teichert; Lei Zhang; Agata Zieba; Anna Dimberg
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization.
The Journal of pathology 2012;228(3):378-90.
2012: Francis M Wulfert; Jan G Zijlstra; Michel M R F Struys; Matijs van Meurs; Peter Heeringa; Martin C Houwertjes; Rianne M Jongman; Neng F Kurniati; Grietje Molema
Age-dependent role of microvascular endothelial and polymorphonuclear cells in lipopolysaccharide-induced acute kidney injury.
Anesthesiology 2012;117(1):126-36.
2012: Sigridur A Asgeirsdóttir; B Banas; Peter Heeringa; Jan A A M Kamps; N F Kurniati; P W Mathieson; T J Rabelink; M A Saleem; S C Satchell; M van Meurs; C van Solingen; A J van Zonneveld; P J Zwiers; Grietje Molema
MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation.
American journal of physiology. Renal physiology 2012;302(12):F1630-9.
2012: Matijs van Meurs; Midori Yano; Jan G Zijlstra; William C Aird; Pedro Castro; Tohru Funahashi; Shulin Lu; Norikazu Maeda; Grietje Molema; Samir M Parikh; Nathan I Shapiro; Ichiro Shimomura; Kiichiro Yano
Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis.
Shock (Augusta, Ga.) 2012;37(4):392-8.
2012: Grietje Molema; William C Aird
Vascular heterogeneity in the kidney.
Seminars in nephrology 2012;32(2):145-55.
2012: Claudia Bergstraesser; Tobias Czymai; Linda Ermantraut; Matthias Goebeler; Simone Hoeger; Maxi Hottenrot; Ralf Loesel; Grietje Molema; Norbert Ponelies; Marc Schmidt; Marc Seelen; Hui Song; Carsten Stich; Willem van Son; Benito A Yard; Neysan Rafat
Inhibition of VCAM-1 expression in endothelial cells by CORM-3: the role of the ubiquitin-proteasome system, p38, and mitochondrial respiration.
Free radical biology & medicine 2012;52(4):794-802.
2012: Gopala K Yakala; Robert Kleemann; Teake Kooistra; Grietje Molema; Martin Schipper; Roel van der Heijden; Peter Y Wielinga; Peter Heeringa
Beneficial effects of an alternating high- fat dietary regimen on systemic insulin resistance, hepatic and renal inflammation and renal function.
PloS one 2012;7(9):e45866.
2011: Michael G Dickinson; Grietje Molema; Hannie Sietsma; Janny Takens; Michel Weij; Pieter Wichers; Beatrijs Bartelds; Bibiche Boersma; Marinus A Borgdorff; Rolf M F Berger
Egr-1 expression during neointimal development in flow-associated pulmonary hypertension.
The American journal of pathology 2011;179(5):2199-209.
2011: Matijs van Meurs; Michiel Vaneker; Francis M Wulfert; Jan G Zijlstra; Leon P H J Aarts; Peter Heeringa; Martin C Houwertjes; Rianne M Jongman; Gert Jan Scheffer; Martin Schipper; Luc J Teppema; Grietje Molema
Hemorrhagic shock-induced endothelial cell activation in a spontaneous breathing and a mechanical ventilation hemorrhagic shock model is induced by a proinflammatory response and not by hypoxia.
Anesthesiology 2011;115(3):474-82.
2011: Piotr S Kowalski; Niek G J Leus; Marcel H J Ruiters; Gerrit L Scherphof; Jan A A M Kamps; Grietje Molema
Targeted siRNA delivery to diseased microvascular endothelial cells: cellular and molecular concepts.
IUBMB life 2011;63(8):648-58.
2011: A H Sikkema; P J Zwiers; Eveline S J M de Bont; Sander H Diks; Anna Dimberg; Eelco W Hoving; W A Kamps; Grietje Molema; M P Peppelenbosch; Wilfred F A den Dunnen
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells.
Neuropathology and applied neurobiology 2011;37(5):538-48.
2011: Lei Yuan; Peter J Zwiers; William C Aird; Manoj Bhasin; George E Davis; Alexandra Le Bras; Grietje Molema; Janice A Nagy; Anastasia Sacharidou; Shou-Ching Shih; Katherine Spokes; Amber N Stratman; Peter Oettgen
RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.
Blood 2011;118(4):1145-53.
2011: M A Hegeman; Pieter M Cobelens; M P Hennus; N J G Jansen; Jaam Kamps; Grietje Molema; M J Schultz; Adrianus J van Vught; Cobi J Heijnen
Liposome-encapsulated dexamethasone attenuates ventilator-induced lung inflammation.
British journal of pharmacology 2011;163(5):1048-58.
2011: Willem M van der Veer; Frank B Niessen; José A Ferreira; Peter J Zwiers; Etty H de Jong; Esther Middelkoop; Grietje Molema
Time course of the angiogenic response during normotrophic and hypertrophic scar formation in humans.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2011;19(3):292-301.
2011: Betty S van der Veen; Min Chen; Ralf Müller; Mirjan M van Timmeren; Arjen H Petersen; Patrice A Lee; Simon C Satchell; Peter W Mathieson; Moin A Saleem; Coen A Stegeman; Jochen Zwerina; Grietje Molema; Peter Heeringa
Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo.
Annals of the rheumatic diseases 2011;70(2):356-65.
2011: Ju Liu; Lei Yuan; Grietje Molema; Erzsébet Regan; Lauren Janes; David Beeler; Katherine C Spokes; Yoshiaki Okada; Takashi Minami; Peter Oettgen; William C Aird
Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle.
Blood 2011;117(1):342-51.
2011: Frederick Pfister; Eva Riedl; Franziska Vom Hagen; Qian Wang; Benito A Yard; Martina Deinzer; Yuxi Feng; Martin Conrad Harmsen; Grietje Molema; Hans-Peter Hammes
Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;28(1):125-36.
2010: Willem M van der Veer; José A Ferreira; Etty H de Jong; Grietje Molema; Frank B Niessen
Perioperative conditions affect long-term hypertrophic scar formation.
Annals of plastic surgery 2010;65(3):321-5.
2010: Annette S H Gouw; Wenjiao Zeng; Marijke Buiskool; Inge Platteel; Marius C van den Heuvel; Sibrand Poppema; Koert P de Jong; Grietje Molema
Molecular characterization of the vascular features of focal nodular hyperplasia and hepatocellular adenoma: a role for angiopoietin-1.
Hepatology (Baltimore, Md.) 2010;52(2):540-9.
2010: Joanna E Adrian; Henriëtte W M Morselt; Regine Süss; Sabine Barnert; Jan Willem Kok; Sigridur A Asgeirsdóttir; Marcel H J Ruiters; Grietje Molema; Jan A A M Kamps
Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells.
Journal of controlled release : official journal of the Controlled Release Society 2010;144(3):341-9.
2010: Wenjiao Zeng; Annette S H Gouw; Marius C van den Heuvel; Grietje Molema; Sibrand Poppema; Eric J van der Jagt; Koert P de Jong
Hepatocellular carcinomas in cirrhotic and noncirrhotic human livers share angiogenic characteristics.
Annals of surgical oncology 2010;17(6):1564-71.
2010: Tobias Czymai; Dorothee Viemann; Carsten Sticht; Grietje Molema; Matthias Goebeler; Marc Schmidt
FOXO3 modulates endothelial gene expression and function by classical and alternative mechanisms.
The Journal of biological chemistry 2010;285(14):10163-78.
2010: Grietje Molema
Heterogeneity in endothelial responsiveness to cytokines, molecular causes, and pharmacological consequences.
Seminars in thrombosis and hemostasis 2010;36(3):246-64.
2010: Michiel Wagemakers; Mariska Sie; Eelco W Hoving; Grietje Molema; Eveline S J M de Bont; Wilfred F A den Dunnen
Tumor vessel biology in pediatric intracranial ependymoma.
Journal of neurosurgery. Pediatrics 2010;5(4):335-41.
2010: Sigridur A Asgeirsdóttir; Eduard G Talman; Inge A de Graaf; Jan A A M Kamps; Simon C Satchell; Peter W Mathieson; Marcel H J Ruiters; Grietje Molema
Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro--a quantitative study.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(2):241-51.
2010: Maria A Hegeman; Marije P Hennus; Matijs van Meurs; Pieter M Cobelens; Annemieke Kavelaars; Nicolaas J G Jansen; Marcus J Schultz; Adrianus J van Vught; Grietje Molema; Cobi J Heijnen
Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury.
PloS one 2010;5(12):e15653.
2010: Johanna Westra; Grietje Molema; C G M Kallenberg
Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis - therapeutic implications.
Current medicinal chemistry 2010;17(3):254-63.
2009: Iryna V Samarska; Matijs van Meurs; Hendrik Buikema; Martin C Houwertjes; Francis M Wulfert; Grietje Molema; Anne H Epema; Robert H Henning
Adjunct nitrous oxide normalizes vascular reactivity changes after hemorrhagic shock in mice under isoflurane anesthesia.
Anesthesiology 2009;111(3):600-8.
2009: Matijs van Meurs; Neng F Kurniati; Francis M Wulfert; Sigridur A Asgeirsdottir; Inge A de Graaf; Simon C Satchell; Peter W Mathieson; Rianne M Jongman; Philipp Kümpers; Jan G Zijlstra; Peter Heeringa; Grietje Molema
Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function.
American journal of physiology. Renal physiology 2009;297(2):F272-81.
2009: Yuxi Feng; Franziska Vom Hagen; Yumei Wang; Susanne Beck; Kay Schreiter; Frederick Pfister; Sigrid Hoffmann; Patrick Wagner; Mathias Seeliger; Grietje Molema; Urban Deutsch; Hans-Peter Hammes
The absence of angiopoietin-2 leads to abnormal vascular maturation and persistent proliferative retinopathy.
Thrombosis and haemostasis 2009;102(1):120-30.
2009: Michiel Wagemakers; Gesiena E van der Wal; Rosa Cuberes; Inés Alvarez; Eva Ma Andrés; Jordi Buxens; José M Vela; Henk Moorlag; J J A Mooij; Grietje Molema
COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature.
Translational oncology 2009;2(1):1-7.
2009: Willem M van der Veer; Monica C T Bloemen; Magda M W Ulrich; Grietje Molema; Paul P van Zuijlen; Esther Middelkoop; Frank B Niessen
Potential cellular and molecular causes of hypertrophic scar formation.
Burns : journal of the International Society for Burn Injuries 2009;35(1):15-29.
2009: Matijs van Meurs; Philipp Kümpers; Jack J M Ligtenberg; John H J M Meertens; Grietje Molema; Jan G Zijlstra
Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?
Critical care (London, England) 2009;13(2):207.
2009: Philipp Kümpers; Matijs van Meurs; Sascha David; Grietje Molema; Johan Bijzet; Alexander Lukasz; Frank Biertz; Hermann Haller; Jan G Zijlstra
Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis.
Critical care (London, England) 2009;13(3):R64.
2009: Mariska Sie; Michiel Wagemakers; Grietje Molema; Jan Jakob A Mooij; Eveline S J M de Bont; Wilfred F A den Dunnen
The angiopoietin 1/angiopoietin 2 balance as a prognostic marker in primary glioblastoma multiforme.
Journal of neurosurgery 2009;110(1):147-55.
2009: Elise Langenkamp; Grietje Molema
Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer.
Cell and tissue research 2009;335(1):205-22.
2008: Wenjiao Zeng; Annette S H Gouw; Marius C van den Heuvel; Peter J Zwiers; pieter zondervan; Sibrand Poppema; Nong Zhang; Inge Platteel; Koert P de Jong; Grietje Molema
The angiogenic makeup of human hepatocellular carcinoma does not favor vascular endothelial growth factor/angiopoietin-driven sprouting neovascularization.
Hepatology (Baltimore, Md.) 2008;48(5):1517-27.
2008: Frederick Pfister; Yuxi Feng; Franziska Vom Hagen; Sigrid Hoffmann; Grietje Molema; Jan-Luuk Hillebrands; Moshe Shani; Urban Deutsch; Hans-Peter Hammes
Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy.
Diabetes 2008;57(9):2495-502.
2008: Marcel H A M Fens; Enrico Mastrobattista; Anko M De Graaff; Frits M Flesch; A Ultee; Jan T Rasmussen; Grietje Molema; Gert Storm; Raymond Schiffelers
Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells.
Blood 2008;111(9):4542-50.
2008: Sigridur A Asgeirsdóttir; Peter J Zwiers; Henriëtte W M Morselt; Henk E Moorlag; Hester I Bakker; Peter Heeringa; Jan Willem Kok; Cees G M Kallenberg; Grietje Molema; Jan A A M Kamps
Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes.
American journal of physiology. Renal physiology 2008;294(3):F554-61.
2008: Marc Tarrus; Almer van der Sloot; Kai Temming; Marie Lacombe; Frank Opdam; Wim J Quax; Grietje Molema; Klaas Poelstra; Robbert J Kok
RGD-avidin-biotin pretargeting to alpha v beta 3 integrin enhances the proapoptotic activity of TNF alpha related apoptosis inducing ligand (TRAIL).
Apoptosis : an international journal on programmed cell death 2008;13(2):225-35.
2008: Matijs van Meurs; Francis M Wulfert; Ageeth J Knol; Ann De Haes; Martin Houwertjes; Leon P H J Aarts; Grietje Molema
Early organ-specific endothelial activation during hemorrhagic shock and resuscitation.
Shock (Augusta, Ga.) 2008;29(2):291-9.
2007: Kai Temming; Damon L Meyer; Roger F Zabinski; Peter D Senter; Klaas Poelstra; Grietje Molema; Robbert J Kok
Improved efficacy of alphavbeta3-targeted albumin conjugates by conjugation of a novel auristatin derivative.
Molecular pharmaceutics 2007;4(5):686-94.
2007: Sigridur A Asgeirsdóttir; Jan A A M Kamps; Hester I Bakker; Peter J Zwiers; Peter Heeringa; Karen van der Weide; Harry van Goor; Arjen H Petersen; Henriëtte W M Morselt; Henk E Moorlag; E Steenbergen; Cees G M Kallenberg; Grietje Molema
Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium.
Molecular pharmacology 2007;72(1):121-31.
2007: Debby M E I Hellebrekers; Veerle Melotte; Emmanuelle Viré; Elise Langenkamp; Grietje Molema; François Fuks; James G Herman; Wim van Criekinge; Arjan W Griffioen; Manon van Engeland
Identification of epigenetically silenced genes in tumor endothelial cells.
Cancer research 2007;67(9):4138-48.
2006: Kai Temming; Marie Lacombe; Henk E Moorlag; S A Asgeirsdottir; László Õrfi; György Kéri; Klaas Poelstra; Grietje Molema; Robbert J Kok
Targeting of the VEGF-kinase inhibitor PTK787 to angiogenic vasculature using RGD-equipped albumin carrier molecules.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e57.
2006: Debby M E I Hellebrekers; Karolien Castermans; Emmanuelle Viré; Ruud Dings; Nicole T H Hoebers; Kevin H Mayo; mirjam oude egbrink; Grietje Molema; François Fuks; Manon van Engeland; Arjan W Griffioen
Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications.
Cancer research 2006;66(22):10770-7.
2006: Kai Temming; Damon L Meyer; Roger F Zabinski; Eli C F Dijkers; Klaas Poelstra; Grietje Molema; Robbert J Kok
Evaluation of RGD-targeted albumin carriers for specific delivery of auristatin E to tumor blood vessels.
Bioconjugate chemistry 2006;17(6):1385-94.
2006: Kai Temming; Marie Lacombe; Roel Q J Schaapveld; László Õrfi; György Kéri; Klaas Poelstra; Grietje Molema; Robbert J Kok
Rational design of RGD-albumin conjugates for targeted delivery of the VEGF-R kinase inhibitor PTK787 to angiogenic endothelium.
ChemMedChem 2006;1(11):1200-3.
2006: Kai Temming; Marie Lacombe; Paul van der Hoeven; Jai Prakash; Teresa Gonzalo; Eli C F Dijkers; László Őrfi; György Kéri; Klaas Poelstra; Grietje Molema; Robbert J Kok
Delivery of the p38 MAPkinase inhibitor SB202190 to angiogenic endothelial cells: development of novel RGD-equipped and PEGylated drug-albumin conjugates using platinum(II)-based drug linker technology.
Bioconjugate chemistry 2006;17(5):1246-55.
2006: Luc Wasungu; Marco Scarzello; Gooitzen van Dam; Grietje Molema; Anno Wagenaar; Jan B F N Engberts; Dick Hoekstra
Transfection mediated by pH-sensitive sugar-based gemini surfactants; potential for in vivo gene therapy applications.
Journal of molecular medicine (Berlin, Germany) 2006;84(9):774-84.
2006: Agnieszka Loboda; Agnieszka Jazwa; Alicja Jozkowicz; Jerzy Dorosz; Jozsef Balla; Grietje Molema; Jozef Dulak
Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells.
Atherosclerosis 2006;187(1):26-30.
2006: Gerben A Koning; Raymond Schiffelers; Marca H M Wauben; Robbert J Kok; Enrico Mastrobattista; Grietje Molema; Timo L M ten Hagen; Gert Storm
Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis.
Arthritis and rheumatism 2006;54(4):1198-208.
2006: Agnieszka Loboda; Agnieszka Jazwa; Alicja Jozkowicz; Grietje Molema; Jozef Dulak
Angiogenic transcriptome of human microvascular endothelial cells: Effect of hypoxia, modulation by atorvastatin.
Vascular pharmacology 2006;44(4):206-14.
2006: Teresa Gonzalo; Eduard Talman; Anke van de Ven; Kai Temming; Rick Greupink; Leonie Beljaars; Catharina Reker-Smit; Dirk K F Meijer; Grietje Molema; Klaas Poelstra; Robbert J Kok
Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):193-203.
2006: Joanna E Adrian; Klaas Poelstra; Gerrit L Scherphof; Grietje Molema; Dirk K F Meijer; Catharina Reker-Smit; Henriëtte W M Morselt; Jan A A M Kamps
Interaction of targeted liposomes with primary cultured hepatic stellate cells: Involvement of multiple receptor systems.
Journal of hepatology 2006;44(3):560-7.
2006: Robert J Griffin; Grietje Molema; Ruud Dings
Angiogenesis treatment, new concepts on the horizon.
Angiogenesis 2006;9(2):67-72.
2006: Ken-ichi Ogawara; Joanna M Kułdo; Koen Oosterhuis; Bart-Jan Kroesen; Marianne G Rots; Christian Trautwein; Toshikiro Kimura; Hidde J Haisma; Grietje Molema
Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene.
Arthritis research & therapy 2006;8(1):R32.
2005: Raymond Schiffelers; A James Mixson; Aslam M Ansari; Marcel H A M Fens; Quingquan Tang; Qin Zhou; Jun Xu; Grietje Molema; Patrick Y Lu; Puthupparampil V Scaria; Gert Storm; Martin C Woodle
Transporting silence: design of carriers for siRNA to angiogenic endothelium.
Journal of controlled release : official journal of the Controlled Release Society 2005;109(1-3):5-14.
2005: Kai Temming; Raymond Schiffelers; Grietje Molema; Robbert J Kok
RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(6):381-402.
2005: Joanna M Kuldo; Jantine L Westra; Sigridur A Asgeirsdóttir; Robbert J Kok; Koen Oosterhuis; Marianne G Rots; Jan Schouten; Pieter C Limburg; Grietje Molema
Differential effects of NF-{kappa}B and p38 MAPK inhibitors and combinations thereof on TNF-{alpha}- and IL-1{beta}-induced proinflammatory status of endothelial cells in vitro.
American journal of physiology. Cell physiology 2005;289(5):C1229-39.
2005: Raymond Schiffelers; Marcel H A M Fens; Adriënne P C A Janssen; Grietje Molema; Gert Storm
Liposomal targeting of angiogenic vasculature.
Current drug delivery 2005;2(4):363-8.
2005: Rogier B Donker; Grietje Molema; Marijke M Faas; Cees G M Kallenberg; Marielle van Pampus; Albertus Timmer; Jan G Aarnoudse
Absence of in vivo generalized pro-inflammatory endothelial activation in severe, early-onset preeclampsia.
Journal of the Society for Gynecologic Investigation 2005;12(7):518-28.
2005: Jantine L Westra; Joanna M Kułdo; Martin H van Rijswijk; Grietje Molema; Pieter C Limburg
Chemokine production and E-selectin expression in activated endothelial cells are inhibited by p38 MAPK (mitogen activated protein kinase) inhibitor RWJ 67657.
International immunopharmacology 2005;5(7-8):1259-69.
2005: Raymond Schiffelers; Josbert M Metselaar; Marcel H A M Fens; Adriënne P C A Janssen; Grietje Molema; Gert Storm
Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice.
Neoplasia (New York, N.Y.) 2005;7(2):118-27.
2005: Rogier B Donker; Sigridur A Asgeirsdóttir; Frans Gerbens; Marielle van Pampus; Cees G M Kallenberg; Gerard te Meerman; Jan G Aarnoudse; Grietje Molema
Plasma factors in severe early-onset preeclampsia do not substantially alter endothelial gene expression in vitro.
Journal of the Society for Gynecologic Investigation 2005;12(2):98-106.
2005: Grietje Molema
Design of vascular endothelium-specific drug-targeting strategies for the treatment of cancer.
Acta biochimica Polonica 2005;52(2):301-10.
2005: Joanna M Kułdo; Ken Ichi Ogawara; Naomi Werner; Sigridur A Asgeirsdóttir; Jan A A M Kamps; Robbert J Kok; Grietje Molema
Molecular pathways of endothelial cell activation for (targeted) pharmacological intervention of chronic inflammatory diseases.
Current vascular pharmacology 2005;3(1):11-39.
2004: Astrid J Schraa; Robbert J Kok; Sander M Botter; Sebo Withoff; Dirk K F Meijer; Lou F M H De Leij; Grietje Molema
RGD-modified anti-CD3 antibodies redirect cytolytic capacity of cytotoxic T lymphocytes toward alphavbeta3-expressing endothelial cells.
International journal of cancer. Journal international du cancer 2004;112(2):279-85.
2004: Agnieszka Masztalerz; Marja J A van Luyn; Naomi Werner; Grietje Molema; Linda A Everse; Willem Den Otter
Treatment with IL-2 and IL-12 inhibits tumour cell division in SL2 lymphoma.
Anticancer research 2004;24(5A):2633-42.
2004: Leonie Beljaars; Barry W A van der Strate; Hester I Bakker; Catharina Reker-Smit; Anne-miek Van Loenen-Weemaes; Frouwke C Wiegmans; Martin C Harmsen; Grietje Molema; Dirk K F Meijer
Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo.
Antiviral research 2004;63(3):197-208.
2004: Willem J M Mulder; Gustav J Strijkers; Arjan W Griffioen; Louis van Bloois; Grietje Molema; Gert Storm; Gerben A Koning; Klaas Nicolay
A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets.
Bioconjugate chemistry 2004;15(4):799-806.
2004: Ken-ichi Ogawara; Marianne G Rots; Robbert J Kok; Henk E Moorlag; Anne-Miek Van Loenen; Dirk K F Meijer; Hidde J Haisma; Grietje Molema
A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo.
Human gene therapy 2004;15(5):433-43.
2004: Raymond Schiffelers; Aslam Ansari; Jun Xu; Qin Zhou; Qingquan Tang; Gert Storm; Grietje Molema; Patrick Y Lu; Puthupparampil V Scaria; Martin C Woodle
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle.
Nucleic acids research 2004;32(19):e149.
2003: Maaike Everts; Sigridur A Asgeirsdóttir; Robbert J Kok; J Twisk; B de Vries; Erik Lubberts; Erwin J Bos; N Werner; D K F Mejer; Grietje Molema
Comparison of E-selectin expression at mRNA and protein levels in murine models of inflammation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52(12):512-8.
2003: Joost A B van der Hoeven; Grietje Molema; Gert Ter Horst; Rennie L Freund; Janneke Wiersema; Reinout van Schilfgaarde; Henri G D Leuvenink; Rutger J Ploeg
Relationship between duration of brain death and hemodynamic (in)stability on progressive dysfunction and increased immunologic activation of donor kidneys.
Kidney international 2003;64(5):1874-82.
2003: Barry W A van der Strate; Jan-Luuk Hillebrands; S S Lycklama à Nijeholt; Leonie Beljaars; Cathrien A Bruggeman; Marja J A van Luyn; Jan Rozing; T Hauw The; Dirk K F Meijer; Grietje Molema; Martin C Harmsen
Dissemination of rat cytomegalovirus through infected granulocytes and monocytes in vitro and in vivo.
Journal of virology 2003;77(20):11274-8.
2003: Raymond Schiffelers; Gerben A Koning; Timo L M ten Hagen; Marcel H A M Fens; Astrid J Schraa; Adriënne P C A Janssen; Robbert J Kok; Grietje Molema; Gert Storm
Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(1-2):115-22.
2003: Sigridur A Asgeirsdóttir; Robbert J Kok; Maaike Everts; Dirk K F Meijer; Grietje Molema
Delivery of pharmacologically active dexamethasone into activated endothelial cells by dexamethasone-anti-E-selectin immunoconjugate.
Biochemical pharmacology 2003;65(10):1729-39.
2003: Marc Weeber; Rein Vos; Henny Klein; Lolkje T W de Jong van den Berg; Alan R Aronson; Grietje Molema
Generating hypotheses by discovering implicit associations in the literature: a case report of a search for new potential therapeutic uses for thalidomide.
Journal of the American Medical Informatics Association : JAMIA 2003;10(3):252-9.
2003: Barry W A van der Strate; Froukje M De Boer; Hester I Bakker; Dirk K F Meijer; Grietje Molema; Martin C Harmsen
Synergy of bovine lactoferrin with the anti-cytomegalovirus drug cidofovir in vitro.
Antiviral research 2003;58(2):159-65.
2003: Adriënne P C A Janssen; Raymond Schiffelers; Timo L M ten Hagen; Gerben A Koning; Astrid J Schraa; Robbert J Kok; Gert Storm; Grietje Molema
Peptide-targeted PEG-liposomes in anti-angiogenic therapy.
International journal of pharmaceutics 2003;254(1):55-8.
2003: Maaike Everts; Gerben A Koning; Robbert J Kok; Sigridur A Asgeirsdóttir; Dietmar Vestweber; Dirk K F Meijer; Gert Storm; Grietje Molema
In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium.
Pharmaceutical research 2003;20(1):64-72.
2002: Astrid J Schraa; Robbert J Kok; Henk E Moorlag; Erwin J Bos; Johannes H Proost; Dirk K F Meijer; Lou F M H De Leij; Grietje Molema
Targeting of RGD-modified proteins to tumor vasculature: a pharmacokinetic and cellular distribution study.
International journal of cancer. Journal international du cancer 2002;102(5):469-75.
2002: S A Asgeirsdottir; N Werner; G Harms; Anke Van den Berg; Grietje Molema
Analysis of in vivo endothelial cell activation applying RT-PCR following endothelial cell isolation by laser dissection microscopy.
Annals of the New York Academy of Sciences 2002;973():586-9.
2002: Robbert J Kok; Maaike Everts; Sigridur A Asgeirsdóttir; Dirk K F Meijer; Grietje Molema
Cellular handling of a dexamethasone-anti-E-selectin immunoconjugate by activated endothelial cells: comparison with free dexamethasone.
Pharmaceutical research 2002;19(11):1730-5.
2002: Sandrine A L Audouy; Lou F M H De Leij; Dick Hoekstra; Grietje Molema
In vivo characteristics of cationic liposomes as delivery vectors for gene therapy.
Pharmaceutical research 2002;19(11):1599-605.
2002: Astrid J Schraa; Robbert J Kok; Agnes D Berendsen; Henk E Moorlag; Erwin J Bos; Dirk K F Meijer; Lou F M H De Leij; Grietje Molema
Endothelial cells internalize and degrade RGD-modified proteins developed for tumor vasculature targeting.
Journal of controlled release : official journal of the Controlled Release Society 2002;83(2):241-51.
2002: Franciscus M H de Groot; Henk J Broxterman; Hans P H M Adams; Alexandra van Vliet; Godefridus I Tesser; Yvonne W Elderkamp; Astrid J Schraa; Robbert J Kok; Grietje Molema; HERBERT PINEDO; Hans W Scheeren
Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug.
Molecular cancer therapeutics 2002;1(11):901-11.
2002: Grietje Molema
Tumor vasculature directed drug targeting: applying new technologies and knowledge to the development of clinically relevant therapies.
Pharmaceutical research 2002;19(9):1251-8.
2002: Leonie Beljaars; René Floris; Ben Berkhout; Catharina Smit; Dirk K F Meijer; Grietje Molema
The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins.
Biochemical pharmacology 2002;63(9):1663-73.
2002: Bart-Jan Kroesen; Pamela M J McLaughlin; Petra H L Schuilenga-Hut; Susan C Jacobs; Grietje Molema; Wijnand Helfrich; Lou F M H De Leij
Tumor-targeted immune complex formation: effects on myeloid cell activation and tumor-directed immune cell migration.
International journal of cancer. Journal international du cancer 2002;98(6):857-63.
2002: Raymond Schiffelers; Grietje Molema; Timo L M ten Hagen; Adriënne P C A Janssen; Astrid J Schraa; Robbert J Kok; Gerben A Koning; Gert Storm
Ligand-targeted liposomes directed against pathological vasculature.
Journal of liposome research 2002;12(1-2):129-35.
2002: Maaike Everts; Robbert J Kok; Sigridur A Asgeirsdóttir; Barbro Melgert; Tom J M Moolenaar; Gerben A Koning; Marja J A van Luyn; Dirk K F Meijer; Grietje Molema
Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin-directed immunoconjugate.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):883-9.
2002: Machteld J van Amerongen; Grietje Molema; Josée Plantinga; Henk E Moorlag; Marja J A van Luyn
Neovascularization and vascular markers in a foreign body reaction to subcutaneously implanted degradable biomaterial in mice.
Angiogenesis 2002;5(3):173-80.
2002: Astrid J Schraa; Maaike Everts; Robbert J Kok; Sigridur A Asgeirsdóttir; Dirk K F Meijer; Lou F M H De Leij; Grietje Molema
Development of vasculature targeting strategies for the treatment of cancer and chronic inflammatory diseases.
Biotechnology annual review 2002;8():133-65.
2002: Raymond Schiffelers; Grietje Molema; Timo L M ten Hagen; Adriënne P C A Janssen; Astrid J Schraa; Robbert J Kok; Gerben A Koning; Gert Storm
Targeting of liposomes to angiogenic endothelial cells.
Cellular & molecular biology letters 2002;7(2):255.
2002: Leonie Beljaars; Hester I Bakker; Barry W A van der Strate; Catharina Smit; Adrian M Duijvestijn; Dirk K F Meijer; Grietje Molema
The antiviral protein human lactoferrin is distributed in the body to cytomegalovirus (CMV) infection-prone cells and tissues.
Pharmaceutical research 2002;19(1):54-62.
2002: Robbert J Kok; Astrid J Schraa; Erwin J Bos; Henk E Moorlag; Sigridur A Asgeirsdóttir; Maaike Everts; Dirk K F Meijer; Grietje Molema
Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics.
Bioconjugate chemistry 2002;13(1):128-35.
2001: Barry W A van der Strate; Leonie Beljaars; Grietje Molema; Martin C Harmsen; Dirk K F Meijer
Antiviral activities of lactoferrin.
Antiviral research 2001;52(3):225-39.
2001: Joost A B van der Hoeven; Susanne L Lindell; Reinout van Schilfgaarde; Grietje Molema; Gert Ter Horst; James H Southard; Rutger J Ploeg
Donor brain death reduces survival after transplantation in rat livers preserved for 20 hr.
Transplantation 2001;72(10):1632-6.
2001: Leonie Beljaars; Peter Olinga; Grietje Molema; Pieter De Bleser; Albert Geerts; Geny M M Groothuis; Dirk K F Meijer; Klaas Poelstra
Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA).
Liver 2001;21(5):320-8.
2001: Dirk K F Meijer; Leonie Beljaars; Grietje Molema; Klaas Poelstra
Disease-induced drug targeting using novel peptide-ligand albumins.
Journal of controlled release : official journal of the Controlled Release Society 2001;72(1-3):157-64.
2001: EB van Leeuwen; G Bea A Wisman; J W Tervaert; L L Palmans; R T van Wijk; Rense Veenstra; Grietje Molema; A G van der Zee; Jan van der Meer; Marcel H J Ruiters
An SV40 large T-antigen immortalized human umbilical vein endothelial cell line for anti-endothelial cell antibody detection.
Clinical and experimental rheumatology 2001;19(3):283-90.
2001: Sebo Withoff; Wijnand Helfrich; Lou F M H De Leij; Grietje Molema
Bi-specific antibody therapy for the treatment of cancer.
Current opinion in molecular therapeutics 2001;3(1):53-62.
2001: Diane Bouïs; Geke A P Hospers; Coby Meijer; Grietje Molema; Nanno H Mulder
Endothelium in vitro: a review of human vascular endothelial cell lines for blood vessel-related research.
Angiogenesis 2001;4(2):91-102.
2001: Grietje Molema; I van Veen-Hof; Anne-miek Van Loenen-Weemaes; Johannes H Proost; L F de Leij; Dirk K F Meijer
Pharmacokinetics and whole body distribution of elastase derived angiostatin (K1-3) in rats.
International journal of cancer. Journal international du cancer 2001;91(1):1-7.
2000: IM Khouw; Pauline B van Wachem; Grietje Molema; Josée Plantinga; Lou F M H De Leij; Marja J A van Luyn
The foreign body reaction to a biodegradable biomaterial differs between rats and mice.
Journal of biomedical materials research 2000;52(3):439-46.
2000: Joost A B van der Hoeven; Gert Ter Horst; Grietje Molema; Paul de Vos; AR Girbes; Folkert Postema; Rennie L Freund; J Wiersema; Reinout van Schilfgaarde; Rutger J Ploeg
Effects of brain death and hemodynamic status on function and immunologic activation of the potential donor liver in the rat.
Annals of surgery 2000;232(6):804-13.
2000: Sandrine A L Audouy; Grietje Molema; Lou de Leij; Dick Hoekstra
Serum as a modulator of lipoplex-mediated gene transfection: dependence of amphiphile, cell type and complex stability.
The journal of gene medicine 2000;2(6):465-76.
2000: EB van Leeuwen; Grietje Molema; Koert P de Jong; Marja J A van Luyn; Freark Dijk; Maarten J H Slooff; Marcel H J Ruiters; Jan van der Meer
One-step method for endothelial cell isolation from large human blood vessels using fibrin glue.
Laboratory investigation; a journal of technical methods and pathology 2000;80(6):987-9.
2000: EB van Leeuwen; Grietje Molema; Marja J A van Luyn; Koert P de Jong; Freark Dijk; Maarten J H Slooff; Marcel H J Ruiters; Jan van der Meer
Scanning electron microscopic analysis of endothelial cell coverage and quality in large vessels from multi-organ donors: effects of preservation on endothelial cell integrity.
Clinical transplantation 2000;14(3):246-51.
2000: Leonie Beljaars; Grietje Molema; Detlef Schuppan; Albert Geerts; Pieter De Bleser; Betty Weert; Dirk K F Meijer; Klaas Poelstra
Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor.
The Journal of biological chemistry 2000;275(17):12743-51.
2000: Wijnand Helfrich; Hidde J Haisma; Viktor Magdolen; T Luther; V J Bom; Jantine L Westra; R van der Hoeven; Bart-Jan Kroesen; Grietje Molema; Lou de Leij
A rapid and versatile method for harnessing scFv antibody fragments with various biological effector functions.
Journal of immunological methods 2000;237(1-2):131-45.
2000: Barbro Melgert; Peter Olinga; V K Jack; Grietje Molema; Dirk K F Meijer; Klaas Poelstra
Dexamethasone coupled to albumin is selectively taken up by rat nonparenchymal liver cells and attenuates LPS-induced activation of hepatic cells.
Journal of hepatology 2000;32(4):603-11.
2000: Grietje Molema; Bart-Jan Kroesen; Wijnand Helfrich; Dirk K F Meijer; Lou F M H De Leij
The use of bispecific antibodies in tumor cell and tumor vasculature directed immunotherapy.
Journal of controlled release : official journal of the Controlled Release Society 2000;64(1-3):229-39.
2000: EB van Leeuwen; Rense Veenstra; R van Wijk; Grietje Molema; A Hoekstra; Marcel H J Ruiters; Jan van der Meer
Characterization of immortalized human umbilical and iliac vein endothelial cell lines after transfection with SV40 large T-antigen.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2000;11(1):15-25.
2000: Grietje Molema; J W Tervaert; Bart-Jan Kroesen; Wijnand Helfrich; Dirk K F Meijer; Lou F M H De Leij
CD3 directed bispecific antibodies induce increased lymphocyte-endothelial cell interactions in vitro.
British journal of cancer 2000;82(2):472-9.
1999: Anneke C Muller Kobold; RT van Wijk; Casper F M Franssen; Grietje Molema; Cees G M Kallenberg; J W Cohen Tervaert
In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis.
Clinical and experimental rheumatology 1999;17(4):433-40.
1999: Leonie Beljaars; Grietje Molema; Betty Weert; H Bonnema; Peter Olinga; Geny M M Groothuis; Dirk K F Meijer; Klaas Poelstra
Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells.
Hepatology (Baltimore, Md.) 1999;29(5):1486-93.
1999: Joost A B van der Hoeven; Rutger J Ploeg; Folkert Postema; Grietje Molema; Paul de Vos; AR Girbes; PT van Suylichem; Gert Ter Horst
Induction of organ dysfunction and activation of inflammatory markers in donor liver and kidney during hypotensive brain death.
Transplantation proceedings 1999;31(1-2):1006-7.
1998: Leonie Beljaars; Klaas Poelstra; Grietje Molema; Dirk K F Meijer
Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation.
Journal of hepatology 1998;29(4):579-88.
1998: Grietje Molema; A W Griffioen
Rocking the foundations of solid tumor growth by attacking the tumor's blood supply.
Immunology today 1998;19(9):392-4.
1998: Grietje Molema; Dirk K F Meijer; L F de Leij
Tumor vasculature targeted therapies: getting the players organized.
Biochemical pharmacology 1998;55(12):1939-45.
1998: Grietje Molema; G Mesander; Bart-Jan Kroesen; Wijnand Helfrich; Dirk K F Meijer; Lou F M H De Leij
Analysis of in vitro lymphocyte adhesion and transendothelial migration by fluorescent-beads-based flow cytometric cell counting.
Cytometry 1998;32(1):37-43.
1998: Wijnand Helfrich; Bart-Jan Kroesen; Rob C Roovers; L Westers; Grietje Molema; Hennie Hoogenboom; Lou de Leij
Construction and characterization of a bispecific diabody for retargeting T cells to human carcinomas.
International journal of cancer. Journal international du cancer 1998;76(2):232-9.
1998: Barbro Melgert; E Wartna; C Lebbe; C Albrecht; Grietje Molema; Klaas Poelstra; Jürg Reichen; Dirk K F Meijer
Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver.
Journal of drug targeting 1998;5(5):329-42.
1997: Bart-Jan Kroesen; J Nieken; D T Sleijfer; Grietje Molema; Elisabeth G E de Vries; H J Groen; Wijnand Helfrich; T Hauw The; Nanno H Mulder; Lou de Leij
Approaches to lung cancer treatment using the CD3 x EGP-2-directed bispecific monoclonal antibody BIS-1.
Cancer immunology, immunotherapy : CII 1997;45(3-4):203-6.
1997: Grietje Molema; Lou F M H De Leij; Dirk K F Meijer
Tumor vascular endothelium: barrier or target in tumor directed drug delivery and immunotherapy.
Pharmaceutical research 1997;14(1):2-10.