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Jan Koster

Research Profile

Disorders

Neuroblastoma

Anatomy

Physiology

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Oligonucleotide Array Sequence Analysis

Chemicals & Drugs

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Protein Structure, Tertiary

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Publications

TOP 3
Jens Bunt; Nancy A Hasselt; Jan Koster; Rogier Versteeg; Danny A Zwijnenburg; Marcel Kool
OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.
Linda J Valentijn; Johan van Nes; Peter G van Sluis; Rachida Ait Aissa; Marloes E C Broekmans; Franciska Haneveld; Jan Koster; Jan J Molenaar; Rogier Versteeg
Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.
Jan J Molenaar; Alexander Schramm; Isabella Bray; Marloes Broekmans; Huib N Caron; Raquel Domingo-Fernández; Ksenija Drabek; Marli E Ebus; Angelika Eggert; Matthias Fischer; Franciska Haneveld; Lukas Heukamp; Kristina Kieckbusch; Ludger Klein-Hitpass; Jan Koster; Sven Lindner; Pieter Mestdagh; Frank Speleman; Annika Sprüssel; Raymond L Stallings; Theresa Thor; Linda J Valentijn; Johan van Nes; Max M van Noesel; Peter G van Sluis; Jo Vandesompele; Luigi Varesio; Rogier Versteeg; Richard Volckmann; Johannes H Schulte
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

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All Publications

2013: Jens Bunt; Nancy A Hasselt; Jan Koster; Rogier Versteeg; Danny A Zwijnenburg; Marcel Kool
OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.
Acta neuropathologica 2013;125(3):385-94.
2012: Linda J Valentijn; Johan van Nes; Peter G van Sluis; Rachida Ait Aissa; Marloes E C Broekmans; Franciska Haneveld; Jan Koster; Jan J Molenaar; Rogier Versteeg
Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(47):19190-5.
2012: Jan J Molenaar; Alexander Schramm; Isabella Bray; Marloes Broekmans; Huib N Caron; Raquel Domingo-Fernández; Ksenija Drabek; Marli E Ebus; Angelika Eggert; Matthias Fischer; Franciska Haneveld; Lukas Heukamp; Kristina Kieckbusch; Ludger Klein-Hitpass; Jan Koster; Sven Lindner; Pieter Mestdagh; Frank Speleman; Annika Sprüssel; Raymond L Stallings; Theresa Thor; Linda J Valentijn; Johan van Nes; Max M van Noesel; Peter G van Sluis; Jo Vandesompele; Luigi Varesio; Rogier Versteeg; Richard Volckmann; Johannes H Schulte
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.
Nature genetics 2012;44(11):1199-206.
2012: Fieke Lamers; Huib N Caron; Ilona J M den Hartog; Marli E Ebus; Jan Koster; Ingrid Øra; Linda Schild; Rogier Versteeg; Ellen M Westerhout; Jan J Molenaar
Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth.
European journal of cancer (Oxford, England : 1990) 2012;48(16):3093-103.
2012: Jens Bunt; Mohamed Hamdi; Nancy E Hasselt; Jan Koster; Rogier Versteeg; Danny A Zwijnenburg; Marcel Kool
OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells.
International journal of cancer. Journal international du cancer 2012;131(2):E21-32.
2012: Kristel Kemper; Jan Koster; Louis Vermeulen; Miranda Versloot; Rogier Versteeg; Joanne Bleackley; Katherine Cameron; Selçuk Colak; Joan H de Jong; Felipe de Sousa e Melo; Jan Paul Medema
Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(11):3132-41.
2012: Jan J Molenaar; Piet Molenaar; Ingrid Øra; Evan E Santo; Linda Schild; Peter Stroeken; Linda J Valentijn; Jennemiek van Arkel; Ida van der Ploeg; Johan van Nes; Max M van Noesel; Peter G van Sluis; Huib N Caron; Marli E Ebus; Mohamed Hamdi; Franciska Haneveld; Jan Koster; Arjan Lakeman; Ellen M Westerhout; Bart A Westerman; Danny A Zwijnenburg; Rogier Versteeg
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes.
Nature 2012;483(7391):589-93.
2012: Fieke Lamers; Huib N Caron; Jan Koster; Linda Schild; Rogier Versteeg; Jan J Molenaar
Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression.
European journal of cancer (Oxford, England : 1990) 2012;48(5):763-71.
2012: Fieke Lamers; Huib N Caron; Jan Koster; Linda Schild; Frank Speleman; Peter G van Sluis; Rogier Versteeg; Ellen M Westerhout; Ingrid Øra; Jan J Molenaar
Identification of BIRC6 as a novel intervention target for neuroblastoma therapy.
BMC cancer 2012;12():285.
2012: Jan J Molenaar; Ingrid Øra; Frank Speleman; Peter G van Sluis; Huib N Caron; Katleen De Preter; Marli E Ebus; David Gisselsson; Jan Koster; Ellen M Westerhout; Rogier Versteeg
Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis.
Genes, chromosomes & cancer 2012;51(1):10-9.
2011: Felipe de Sousa E Melo; Evelien Dekker; Evelyn Fessler; Jan Koster; Joyce Buikhuisen; Kate Cameron; Selcuk Colak; Joan H de Jong; Steven T Pals; Pramudita R Prasetyanti; Dick J Richel; Hans Rodermond; Jurriaan B Tuynman; Marc J van de Vijver; Saskia P van den Bergh; Chris M van der Loos; Louis Vermeulen; Rogier Versteeg; Jan Paul Medema
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.
Cell stem cell 2011;9(5):476-85.
2011: Fieke Lamers; Linda Schild; Ida van der Ploeg; Rogier Versteeg; Huib N Caron; Marli E Ebus; Bo R Hansen; Troels Koch; Jan Koster; Jan J Molenaar
Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe.
Endocrine-related cancer 2011;18(6):657-68.
2011: Jens Bunt; Nancy E Hasselt; Jan Koster; Rogier Versteeg; Danny A Zwijnenburg; Marcel Kool
Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma.
PloS one 2011;6(10):e26058.
2010: Jens Bunt; Talitha G de Haas; Nancy E Hasselt; Danny A Zwijnenburg; Jan Koster; Rogier Versteeg; Marcel Kool
Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines.
Molecular cancer research : MCR 2010;8(10):1344-57.
2010: Michael Hölzel; Sidong Huang; Jan Koster; Ingrid Øra; Arjan Lakeman; Huib Caron; Wouter Nijkamp; Jing Xie; Tom Callens; Shahab Asgharzadeh; Robert C Seeger; Ludwine MESSIAEN; Rogier Versteeg; René Bernards
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 2010;142(2):218-29.
2010: Tamás Borsics; Emma Lundberg; Dirk Geerts; Dana-Lynn Takeko Koomoa; Jan Koster; Kenneth Wester; André S Bachmann
Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration.
Cancer science 2010;101(7):1624-31.
2010: Dirk Geerts; Jan Koster; David Albert; Dana-Lynn Takeko Koomoa; David J Feith; Anthony E Pegg; Richard Volckmann; Huib N Caron; Rogier Versteeg; André S Bachmann
The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.
International journal of cancer. Journal international du cancer 2010;126(9):2012-24.
2010: Ingrid Revet; Gerda Huizenga; Jan Koster; Richard Volckmann; Peter G van Sluis; Rogier Versteeg; Dirk Geerts
MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3.
Cancer letters 2010;289(2):195-207.
2009: Jan J Molenaar; Marli E Ebus; Dirk Geerts; Jan Koster; Fieke Lamers; Linda J Valentijn; Ellen M Westerhout; Rogier Versteeg; Huib N Caron
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12968-73.
2009: Johannes H Schulte; Falk Pentek; Wolfgang Hartmann; Alexander Schramm; Nicolaus Friedrichs; Ingrid Øra; Jan Koster; Rogier Versteeg; Jutta Kirfel; Reinhard Buettner; Angelika Eggert
The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo.
International journal of cancer. Journal international du cancer 2009;124(10):2488-94.
2009: Sidong Huang; Jamila Laoukili; Mirjam T Epping; Jan Koster; Michael Hölzel; Bart A Westerman; Wouter Nijkamp; Akiko Hata; Shahab Asgharzadeh; Robert C Seeger; Rogier Versteeg; Roderick L Beijersbergen; René Bernards
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.
Cancer cell 2009;15(4):328-40.
2009: Sander R van Hooff; Jan Koster; Tim Hulsen; Barbera van Schaik; Marco Roos; Marcel F van Batenburg; Rogier Versteeg; Antoine H C van Kampen
The construction of genome-based transcriptional units.
Omics : a journal of integrative biology 2009;13(2):105-14.
2009: Johannes H Schulte; Soyoung Lim; Alexander Schramm; Nicolaus Friedrichs; Jan Koster; Rogier Versteeg; Ingrid Øra; Kristian Pajtler; Ludger Klein-Hitpass; Steffi Kuhfittig-Kulle; Eric Metzger; Roland Schüle; Angelika Eggert; Reinhard Buettner; Jutta Kirfel
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy.
Cancer research 2009;69(5):2065-71.
2008: Jan J Molenaar; Marli E Ebus; Jan Koster; Peter G van Sluis; Carel J M van Noesel; Rogier Versteeg; Huib N Caron
Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.
Cancer research 2008;68(8):2599-609.
2008: Pantelis Hatzis; Laurens G van der Flier; Marc A van Driel; Victor Guryev; Fiona Nielsen; Sergei Denissov; Isaäc J Nijman; Jan Koster; Evan E Santo; Willem Welboren; Rogier Versteeg; Edwin Cuppen; Marc van de Wetering; Hans Clevers; Hendrik G Stunnenberg
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.
Molecular and cellular biology 2008;28(8):2732-44.
2008: Arjen Koppen; Rachida Ait-Aissa; Jan Koster; Ingrid Øra; Johannes Bras; Peter G van Sluis; Huib N Caron; Rogier Versteeg; Linda J Valentijn
Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN.
International journal of cancer. Journal international du cancer 2008;122(7):1455-64.
2008: Ingrid Revet; Gerda Huizenga; Alvin Chan; Jan Koster; Richard Volckmann; Peter G van Sluis; Ingrid Øra; Rogier Versteeg; Dirk Geerts
The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma.
Experimental cell research 2008;314(4):707-19.
2008: Johannes H M Merks; Heval M Ozgen; Jan Koster; Aeilko H Zwinderman; Huib N Caron; Raoul Hennekam
Prevalence and patterns of morphological abnormalities in patients with childhood cancer.
JAMA : the journal of the American Medical Association 2008;299(1):61-9.
2008: Marcel Kool; Jan Koster; Jens Bunt; Nancy E Hasselt; Arjan Lakeman; Peter G van Sluis; Dirk Troost; Netteke Schouten-van Meeteren; Huib N Caron; Jacqueline Cloos; Alan Mrsić; Bauke Ylstra; Wieslawa Grajkowska; Wolfgang Hartmann; Torsten Pietsch; David Ellison; Steven C Clifford; Rogier Versteeg
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.
PloS one 2008;3(8):e3088.
2007: Dirk Geerts; Christopher J Wallick; Dana-Lynn Takeko Koomoa; Jan Koster; Rogier Versteeg; Ramon Christopher V Go; André S Bachmann
Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(21):6312-9.
2007: Arjen Koppen; Rachida Ait-Aissa; Jan Koster; Peter G van Sluis; Ingrid Øra; Huib N Caron; Richard Volckmann; Rogier Versteeg; Linda J Valentijn
Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma.
European journal of cancer (Oxford, England : 1990) 2007;43(16):2413-22.
2007: Arjen Koppen; Rachida Ait-Aissa; Saskia Hopman; Jan Koster; Franciska Haneveld; Rogier Versteeg; Linda J Valentijn
Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation.
Cancer letters 2007;256(2):218-28.
2007: Hinco J Gierman; Mireille H G Indemans; Jan Koster; Sandra Goetze; Jurgen Seppen; Dirk Geerts; Roel Van Driel; Rogier Versteeg
Domain-wide regulation of gene expression in the human genome.
Genome research 2007;17(9):1286-95.
2007: Sandra Goetze; Julio Mateos-Langerak; Hinco J Gierman; Wim de Leeuw; Osdilly Giromus; Mireille H G Indemans; Jan Koster; Vladan Ondrej; Rogier Versteeg; Roel Van Driel
The three-dimensional structure of human interphase chromosomes is related to the transcriptome map.
Molecular and cellular biology 2007;27(12):4475-87.
2007: Gaëll Mainguy; Jan Koster; Joost Woltering; Hans Jansen; Antony Durston
Extensive polycistronism and antisense transcription in the mammalian Hox clusters.
PloS one 2007;2(4):e356.
2006: Linda J Valentijn; Jan Koster; Rogier Versteeg
Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.
Genomics 2006;87(4):483-9.
2004: Jan Koster; S van Wilpe; Ingrid Kuikman; Sandy H M Litjens; Arnoud Sonnenberg
Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.
Molecular biology of the cell 2004;15(3):1211-23.
2004: Jan Koster; Luca Borradori; Arnoud Sonnenberg
Hemidesmosomes: molecular organization and their importance for cell adhesion and disease.
Handbook of experimental pharmacology 2004;(165):243-80.
2004: Lionel Fontao; Kaisa Tasanen; Marcel Huber; Daniel Hohl; Jan Koster; Leena Bruckner-Tuderman; Arnoud Sonnenberg; Luca Borradori
Molecular consequences of deletion of the cytoplasmic domain of bullous pemphigoid 180 in a patient with predominant features of epidermolysis bullosa simplex.
The Journal of investigative dermatology 2004;122(1):65-72.
2003: Sandy H M Litjens; Jan Koster; Ingrid Kuikman; Sandra van Wilpe; Jose M de Pereda; Arnoud Sonnenberg
Specificity of binding of the plectin actin-binding domain to beta4 integrin.
Molecular biology of the cell 2003;14(10):4039-50.
2003: Emmanuel Laffitte; Reza Shafaatian; Lionel Fontao; Bertrand Favre; Jan Koster; Jean-Hilaire Saurat; Michel Monod; Luca Borradori
Production of the bullous pemphigoid antigen 230 (BP230) by Saccharomyces cerevisiae and Pichia pastoris.
Protein expression and purification 2003;29(2):141-7.
2003: Jan Koster; Dirk Geerts; Bertrand Favre; Luca Borradori; Arnoud Sonnenberg
Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.
Journal of cell science 2003;116(Pt 2):387-99.
2002: Haquima El Mourabit; Patrice Poinat; Jan Koster; Holger Sondermann; Viktor Wixler; Elmar Wegener; Emmanuel Laplantine; Dirk Geerts; Elisabeth Georges-Labouesse; Arnoud Sonnenberg; Monique Aumailley
The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(2):207-14.
2001: Jan Koster; Ingrid Kuikman; Maaike Kreft; Arnoud Sonnenberg
Two different mutations in the cytoplasmic domain of the integrin beta 4 subunit in nonlethal forms of epidermolysis bullosa prevent interaction of beta 4 with plectin.
The Journal of investigative dermatology 2001;117(6):1405-11.
2001: Bertrand Favre; Lionel Fontao; Jan Koster; R Shafaatian; Fabienne Jaunin; Jean-Hilaire Saurat; Arnoud Sonnenberg; Luca Borradori
The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression.
The Journal of biological chemistry 2001;276(35):32427-36.
2001: Lionel Fontao; Dirk Geerts; Ingrid Kuikman; Jan Koster; Duco Kramer; Arnoud Sonnenberg
The interaction of plectin with actin: evidence for cross-linking of actin filaments by dimerization of the actin-binding domain of plectin.
Journal of cell science 2001;114(Pt 11):2065-76.