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Ole Henrik Brekke

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

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Lene Alsøe; John Stacy; Alexander Fosså; Steinar Funderud; Ole Henrik Brekke; Gustav Gaudernack
Identification of prostate cancer antigens by automated high-throughput filter immunoscreening.
Geir Åge Løset; Elin Lunde; Bjarne Bogen; Ole Henrik Brekke; Inger Sandlie
Functional phage display of two murine alpha/beta T-cell receptors is strongly dependent on fusion format, mode and periplasmic folding assistance.
Gøril Berntzen; Ole Henrik Brekke; Seyed Ali Mousavi; Jan Terje Andersen; Terje E Michaelsen; Trond Berg; Inger Sandlie; Vigdis Lauvrak
Characterization of an FcgammaRI-binding peptide selected by phage display.

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All Publications

2008: Lene Alsøe; John Stacy; Alexander Fosså; Steinar Funderud; Ole Henrik Brekke; Gustav Gaudernack
Identification of prostate cancer antigens by automated high-throughput filter immunoscreening.
Journal of immunological methods 2008;330(1-2):12-23.
2007: Geir Åge Løset; Elin Lunde; Bjarne Bogen; Ole Henrik Brekke; Inger Sandlie
Functional phage display of two murine alpha/beta T-cell receptors is strongly dependent on fusion format, mode and periplasmic folding assistance.
Protein engineering, design & selection : PEDS 2007;20(9):461-72.
2006: Gøril Berntzen; Ole Henrik Brekke; Seyed Ali Mousavi; Jan Terje Andersen; Terje E Michaelsen; Trond Berg; Inger Sandlie; Vigdis Lauvrak
Characterization of an FcgammaRI-binding peptide selected by phage display.
Protein engineering, design & selection : PEDS 2006;19(3):121-8.
2006: Terje E Michaelsen; John E Thommesen; Oistein Ihle; Tone F Gregers; Randi H Sandin; Ole Henrik Brekke; Inger Sandlie
A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells.
European journal of immunology 2006;36(1):129-38.
2005: Geir Åge Løset; Inger Løbersli; Anita Kavlie; John Stacy; Tine Borgen; Louise Kausmally; Else Hvattum; Bjørg Simonsen; Maria Befring Hovda; Ole Henrik Brekke
Construction, evaluation and refinement of a large human antibody phage library based on the IgD and IgM variable gene repertoire.
Journal of immunological methods 2005;299(1-2):47-62.
2005: Herald Reiersen; Inger Løbersli; Geir Åge Løset; Else Hvattum; Bjørg Simonsen; John Stacy; Duncan McGregor; Kevin Fitzgerald; Martin Welschof; Ole Henrik Brekke; Ole J Marvik
Covalent antibody display--an in vitro antibody-DNA library selection system.
Nucleic acids research 2005;33(1):e10.
2004: Louise Kausmally; K Waalen; Inger Løbersli; Else Hvattum; G Berntsen; Terje E Michaelsen; Ole Henrik Brekke
Neutralizing human antibodies to varicella-zoster virus (VZV) derived from a VZV patient recombinant antibody library.
The Journal of general virology 2004;85(Pt 12):3493-500.
2003: John Stacy; Louise Kausmally; Bjørg Simonsen; Silje H Nordgard; Lene Alsøe; Terje E Michaelsen; Ole Henrik Brekke
Direct isolation of recombinant human antibodies against group B Neisseria meningitidis from scFv expression libraries.
Journal of immunological methods 2003;283(1-2):247-59.
2003: Ole Henrik Brekke; Geir Åge Løset
New technologies in therapeutic antibody development.
Current opinion in pharmacology 2003;3(5):544-50.
2003: Amir Moghaddam; Tine Borgen; John Stacy; Louise Kausmally; Bjørg Simonsen; Ole J Marvik; Ole Henrik Brekke; Michael Braunagel
Identification of scFv antibody fragments that specifically recognise the heroin metabolite 6-monoacetylmorphine but not morphine.
Journal of immunological methods 2003;280(1-2):139-55.
2003: Ole Henrik Brekke; Inger Sandlie
Therapeutic antibodies for human diseases at the dawn of the twenty-first century.
Nature reviews. Drug discovery 2003;2(1):52-62.
2003: Ole Henrik Brekke; John E Thommesen
Tailoring natural effector functions. Antibody engineering beyond humanization.
Methods in molecular biology (Clifton, N.J.) 2003;207():383-91.
2002: Elin Lunde; Vigdis Lauvrak; Ingunn B Rasmussen; Karoline W Schjetne; Keith M Thompson; Terje E Michaelsen; Ole Henrik Brekke; Ludvig M Sollid; Bjarne Bogen; Inger Sandlie
Troybodies and pepbodies.
Biochemical Society transactions 2002;30(4):500-6.
2000: John E Thommesen; Terje E Michaelsen; Inger Sandlie; G Å Løset; Ole Henrik Brekke
Lysine 322 in the human IgG3 C(H)2 domain is crucial for antibody dependent complement activation.
Molecular immunology 2000;37(16):995-1004.
1998: Kenneth H Roux; L Strelets; Ole Henrik Brekke; Inger Sandlie; Terje E Michaelsen
Comparisons of the ability of human IgG3 hinge mutants, IgM, IgE, and IgA2, to form small immune complexes: a role for flexibility and geometry.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):4083-90.
1997: Vigdis Lauvrak; Ole Henrik Brekke; Oistein Ihle; BH Lindqvist
Identification and characterisation of C1q-binding phage displayed peptides.
Biological chemistry 1997;378(12):1509-19.
1996: Ole Henrik Brekke; Terje E Michaelsen; R Sandlin; Inger Sandlie
Activation of complement by an IgG molecule without a genetic hinge.
Nature 1996;383(6595):103.
1995: Ole Henrik Brekke; Terje E Michaelsen; Inger Sandlie
The structural requirements for complement activation by IgG: does it hinge on the hinge?
Immunology today 1995;16(2):85-90.
1994: Ole Henrik Brekke; Terje E Michaelsen; Audun Aase; Randi H Sandin; Inger Sandlie
Human IgG isotype-specific amino acid residues affecting complement-mediated cell lysis and phagocytosis.
European journal of immunology 1994;24(10):2542-7.
1994: Terje E Michaelsen; Ole Henrik Brekke; Audun Aase; Randi H Sandin; Bjørn Bremnes; Inger Sandlie
One disulfide bond in front of the second heavy chain constant region is necessary and sufficient for effector functions of human IgG3 without a genetic hinge.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9243-7.
1993: Ole Henrik Brekke; Bjørn Bremnes; Randi H Sandin; Audun Aase; Terje E Michaelsen; Inger Sandlie
Human IgG3 can adopt the disulfide bond pattern characteristic for IgG1 without resembling it in complement mediated cell lysis.
Molecular immunology 1993;30(16):1419-25.
1993: Audun Aase; Inger Sandlie; Lars Norderhaug; Ole Henrik Brekke; Terje E Michaelsen
The extended hinge region of IgG3 is not required for high phagocytic capacity mediated by Fc gamma receptors, but the heavy chains must be disulfide bonded.
European journal of immunology 1993;23(7):1546-51.
1993: Ole Henrik Brekke; Terje E Michaelsen; Randi H Sandin; Inger Sandlie
Activation of complement by an IgG molecule without a genetic hinge.
Nature 1993;363(6430):628-30.
1991: Lars Norderhaug; Ole Henrik Brekke; Bjørn Bremnes; Randi H Sandin; Audun Aase; Terje E Michaelsen; Inger Sandlie
Chimeric mouse human IgG3 antibodies with an IgG4-like hinge region induce complement-mediated lysis more efficiently than IgG3 with normal hinge.
European journal of immunology 1991;21(10):2379-84.