FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Ajaikumar Kunnumakkara

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Tumor Cell Line

Living Beings

Procedures

Disorders

Phenomena

Blotting, Western

Co-author Network

Publications

TOP 3
Ajaikumar Kunnumakkara; Jayaraj Ravindran; Bokyung Sung; Zhimin Tong; Amit Deorukhkar; Sanjit Dey; Parmeswaran Diagaradjane; Juri G Gelovani; Sushovan Guha; Cemile Koca; Sunil Krishnan; Bharat B Aggarwal
Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets.
Preetha Anand; Ajaikumar Kunnumakkara; Kallikat N Rajasekharan; Bokyung Sung; Bharat B Aggarwal
Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.
Ajaikumar Kunnumakkara; Bokyung Sung; Jayaraj Ravindran; Parmeswaran Diagaradjane; Amit Deorukhkar; Sanjit Dey; Cemile Koca; Vivek R Yadav; Zhimin Tong; Juri G Gelovani; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Ajaikumar Kunnumakkara (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Ajaikumar Kunnumakkara; Jayaraj Ravindran; Bokyung Sung; Zhimin Tong; Amit Deorukhkar; Sanjit Dey; Parmeswaran Diagaradjane; Juri G Gelovani; Sushovan Guha; Cemile Koca; Sunil Krishnan; Bharat B Aggarwal
Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets.
International journal of cancer. Journal international du cancer 2012;131(3):E292-303.
2011: Preetha Anand; Ajaikumar Kunnumakkara; Kallikat N Rajasekharan; Bokyung Sung; Bharat B Aggarwal
Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.
Biochemical pharmacology 2011;82(12):1901-9.
2010: Ajaikumar Kunnumakkara; Bokyung Sung; Jayaraj Ravindran; Parmeswaran Diagaradjane; Amit Deorukhkar; Sanjit Dey; Cemile Koca; Vivek R Yadav; Zhimin Tong; Juri G Gelovani; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.
Cancer research 2010;70(21):8695-705.
2010: Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Gautam Sethi; Parmeswaran Diagaradjane; Preetha Anand; Manoj Pandey; Juri G Gelovani; Sunil Krishnan; Sushovan Guha; Bharat B Aggarwal
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.
International journal of cancer. Journal international du cancer 2010;127(2):257-68.
2010: Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Nobuo Ochi; Zhimin Tong; Amit Deorukhkar; Bokyung Sung; Lloyd Kelland; Stephen Jamieson; Rachel Sutherland; Tony Raynham; Mark Charles; Azadeh Bagherzadeh; Azadeh Bagherazadeh; Caroline Foxton; Alexandra Boakes; Muddasar Farooq; Dipen Maru; Parmeswaran Diagaradjane; Yoichi Matsuo; James Sinnett-Smith; Juri G Gelovani; Sunil Krishnan; Bharat B Aggarwal; Enrique Rozengurt; Christopher R Ireson; Sushovan Guha
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.
Molecular cancer therapeutics 2010;9(5):1136-46.
2010: Preetha Anand; Hareesh B. Nair; Bokyung Sung; Ajaikumar Kunnumakkara; Vivek R Yadav; Rajeshwar Tekmal; Bharat B Aggarwal
Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.
Biochemical pharmacology 2010;79(3):330-8.
2009: Ajaikumar Kunnumakkara; Parmeswaran Diagaradjane; Preetha Anand; Kuzhuvelil B Harikumar; Harikumar B Kuzhuvelil; Amit Deorukhkar; Juri G Gelovani; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
International journal of cancer. Journal international du cancer 2009;125(9):2187-97.
2009: Bharat B Aggarwal; Ajaikumar Kunnumakkara; Kuzhuvelil B Harikumar; Shan R Gupta; Sheeja T Tharakan; Cemile Koca; Sanjit Dey; Bokyung Sung
Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.
Annals of the New York Academy of Sciences 2009;1171():59-76.
2009: Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Preetha Anand; Sushovan Guha; Bharat B Aggarwal
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
Molecular cancer therapeutics 2009;8(4):959-70.
2009: Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Kwang Seok Ahn; Preetha Anand; Sunil Krishnan; Sushovan Guha; Bharat B Aggarwal
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Blood 2009;113(9):2003-13.
2008: Preetha Anand; Sherin G Thomas; Ajaikumar Kunnumakkara; Chitra Sundaram; Kuzhuvelil B Harikumar; Bokyung Sung; Sheeja T Tharakan; Krishna Misra; Indira K Priyadarsini; Kallikat N Rajasekharan; Bharat B Aggarwal
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Biochemical pharmacology 2008;76(11):1590-611.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
Biochemical pharmacology 2008;76(11):1404-16.
2008: Preetha Anand; Ajaikumar Kunnumakkara; Kuzhuvelil B Harikumar; Kwang Seok Ahn; Vladimir Badmaev; Bharat B Aggarwal
Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.
Cancer research 2008;68(21):8861-70.
2008: Ajaikumar Kunnumakkara; Preetha Anand; Bharat B Aggarwal
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
Cancer letters 2008;269(2):199-225.
2008: Ajaikumar Kunnumakkara; Haruyo Ichikawa; Preetha Anand; Chiramel J Mohankumar; Padmanabhan S Hema; Mangalam S Nair; Bharat B Aggarwal
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Molecular cancer therapeutics 2008;7(10):3306-17.
2008: Bharat B Aggarwal; Ajaikumar Kunnumakkara; Kuzhuvelil B Harikumar; Sheeja T Tharakan; Bokyung Sung; Preetha Anand
Potential of spice-derived phytochemicals for cancer prevention.
Planta medica 2008;74(13):1560-9.
2008: Preetha Anand; Chitra Sundaram; Sonia Jhurani; Ajaikumar Kunnumakkara; Bharat B Aggarwal
Curcumin and cancer: an "old-age" disease with an "age-old" solution.
Cancer letters 2008;267(1):133-64.
2008: Zhimin Tong; Ajaikumar Kunnumakkara; Huamin Wang; Yoichi Matsuo; Parmeswaran Diagaradjane; Kuzhuvelil B Harikumar; Vijaya Ramachandran; Bokyung Sung; Arup Chakraborty; Robert S Bresalier; Craig D Logsdon; Bharat B Aggarwal; Sunil Krishnan; Sushovan Guha
Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer.
Cancer research 2008;68(15):6100-8.
2008: Navneet Dhillon; Bharat B Aggarwal; Robert A Newman; Robert A Wolff; Ajaikumar Kunnumakkara; James L Abbruzzese; Chaan S Ng; Vladimir Badmaev; Razelle Kurzrock
Phase II trial of curcumin in patients with advanced pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(14):4491-9.
2008: Manoj Pandey; Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Cancer research 2008;68(13):5370-9.
2008: Chandra Iyer; Astrid Kosters; Gautam Sethi; Ajaikumar Kunnumakkara; Bharat B Aggarwal; James Versalovic
Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling.
Cellular microbiology 2008;10(7):1442-52.
2008: Amit Verma; Sushovan Guha; Parmeswaran Diagaradjane; Ajaikumar Kunnumakkara; Angela M Sanguino; Gabriel Lopez-Berestein; Anil K Sood; Bharat B Aggarwal; Sunil Krishnan; Juri G Gelovani; Kapil Mehta
Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(8):2476-83.
2008: Ajaikumar Kunnumakkara; Parmeswaran Diagaradjane; Sushovan Guha; Amit Deorukhkar; Shujun Shentu; Bharat B Aggarwal; Sunil Krishnan
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2128-36.
2008: Ajay Goel; Ajaikumar Kunnumakkara; Bharat B Aggarwal
Curcumin as "Curecumin": from kitchen to clinic.
Biochemical pharmacology 2008;75(4):787-809.
2007: Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.
Blood 2007;110(10):3517-25.
2007: Preetha Anand; Ajaikumar Kunnumakkara; Robert A Newman; Bharat B Aggarwal
Bioavailability of curcumin: problems and promises.
Molecular pharmaceutics 2007;4(6):807-18.
2007: Santosh K Sandur; Haruyo Ichikawa; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Gautam Sethi; Bharat B Aggarwal
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
Free radical biology & medicine 2007;43(4):568-80.
2007: Manoj Pandey; Santosh K Sandur; Bokyung Sung; Gautam Sethi; Ajaikumar Kunnumakkara; Bharat B Aggarwal
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
The Journal of biological chemistry 2007;282(24):17340-50.
2007: Ajaikumar Kunnumakkara; Asha S Nair; Kwang Seok Ahn; Manoj Pandey; Zhengfang Yi; Mingyao Liu; Bharat B Aggarwal
Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.
Blood 2007;109(12):5112-21.
2007: Yvonne G Lin; Ajaikumar Kunnumakkara; Asha Nair; William M Merritt; Liz Y Han; Guillermo N Armaiz-Pena; Aparna A Kamat; Whitney A Spannuth; David M Gershenson; Susan K Lutgendorf; Bharat B Aggarwal; Anil K Sood
Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3423-30.
2007: Dinesh Khanna; Gautam Sethi; Kwang Seok Ahn; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Amita Aggarwal; Bharat B Aggarwal
Natural products as a gold mine for arthritis treatment.
Current opinion in pharmacology 2007;7(3):344-51.
2007: Manisha Bhutani; Ashutosh K Pathak; Asha S Nair; Ajaikumar Kunnumakkara; Sushovan Guha; Gautam Sethi; Bharat B Aggarwal
Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):3024-32.
2007: Ajaikumar Kunnumakkara; Sushovan Guha; Sunil Krishnan; Parmeswaran Diagaradjane; Juri G Gelovani; Bharat B Aggarwal
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Cancer research 2007;67(8):3853-61.
2006: Bharat B Aggarwal; Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Haruyo Ichikawa
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Annals of the New York Academy of Sciences 2006;1091():151-69.
2006: Asha S Nair; Shishir Shishodia; Kwang Seok Ahn; Ajaikumar Kunnumakkara; Gautam Sethi; Bharat B Aggarwal
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5612-22.
2006: Aman P Mann; Amit Verma; Gautam Sethi; Bramanandam Manavathi; Huamin Wang; Jansina Y Fok; Ajaikumar Kunnumakkara; Rakesh Kumar; Bharat B Aggarwal; Kapil Mehta
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway.
Cancer research 2006;66(17):8788-95.