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Annalisa Bucchi

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Annalisa Bucchi; Andrea Barbuti; Mirko Baruscotti; Martino Bolognesi; Stefano Micheloni; Marco Nardini; Dario DiFrancesco
Identification of the molecular site of ivabradine binding to HCN4 channels.
Annalisa Bucchi; Dario DiFrancesco; Andrea Barbuti; Mirko Baruscotti
Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models.
Jacopo C DiFrancesco; Carlo Ferrarese; Silvana Franceschetti; Raffaella Milanesi; Benedetta Terragni; Andrea Barbuti; Mirko Baruscotti; Georgia Bottelli; Annalisa Bucchi; Stefania Coco; Dario DiFrancesco
Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.

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All Publications

2013: Annalisa Bucchi; Andrea Barbuti; Mirko Baruscotti; Martino Bolognesi; Stefano Micheloni; Marco Nardini; Dario DiFrancesco
Identification of the molecular site of ivabradine binding to HCN4 channels.
PloS one 2013;8(1):e53132.
2012: Annalisa Bucchi; Dario DiFrancesco; Andrea Barbuti; Mirko Baruscotti
Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models.
Frontiers in physiology 2012;3():240.
2011: Jacopo C DiFrancesco; Carlo Ferrarese; Silvana Franceschetti; Raffaella Milanesi; Benedetta Terragni; Andrea Barbuti; Mirko Baruscotti; Georgia Bottelli; Annalisa Bucchi; Stefania Coco; Dario DiFrancesco
Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(48):17327-37.
2011: Mirko Baruscotti; Annalisa Bucchi; Carlo Viscomi; G Mandelli; G Giacomo Consalez; Tomaso Gnecchi-Rusconi; Nicola Montano; Karina Rabello Casali; Stefano Micheloni; Andrea Barbuti; Dario DiFrancesco
Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1705-10.
2010: Mirko Baruscotti; Andrea Barbuti; Annalisa Bucchi
The cardiac pacemaker current.
Journal of molecular and cellular cardiology 2010;48(1):55-64.
2009: Xin Zhao; Annalisa Bucchi; Ronit V Oren; Yelena Kryukova; Wen Dun; colleen clancy; Richard B Robinson
In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality.
The Journal of physiology 2009;587(Pt 7):1513-25.
2009: Lev Protas; Wen Dun; Zhiheng Jia; Jia Lu; Annalisa Bucchi; Sindhu Kumari; Ming Chen; Ira S Cohen; Michael R Rosen; Emilia Entcheva; Richard B Robinson
Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium.
Cardiovascular research 2009;81(3):528-35.
2008: Alexei N Plotnikov; Annalisa Bucchi; Iryna N Shlapakova; Peter Danilo; Peter R Brink; Richard B Robinson; Ira S Cohen; Michael R Rosen
HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade.
Heart rhythm : the official journal of the Heart Rhythm Society 2008;5(2):282-8.
2007: Phillip Pian; Annalisa Bucchi; Anthony DeCostanzo; Richard B Robinson; Steven A Siegelbaum
Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C.
Pflügers Archiv : European journal of physiology 2007;455(1):125-45.
2007: Annalisa Bucchi; Mirko Baruscotti; Richard B Robinson; Dario DiFrancesco
Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current.
Journal of molecular and cellular cardiology 2007;43(1):39-48.
2007: Annalisa Bucchi; Andrea Barbuti; Mirko Baruscotti; Dario DiFrancesco
Heart rate reduction via selective 'funny' channel blockers.
Current opinion in pharmacology 2007;7(2):208-13.
2006: Phillip Pian; Annalisa Bucchi; Richard B Robinson; Steven A Siegelbaum
Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2.
The Journal of general physiology 2006;128(5):593-604.
2006: Annalisa Bucchi; Alexei N Plotnikov; Iryna N Shlapakova; Peter Danilo; Yelena Kryukova; Jihong Qu; Zhongju Lu; Huilin Liu; Zongming Pan; Irina A Potapova; Bruce H Kenknight; Steven Girouard; Ira S Cohen; Peter R Brink; Richard B Robinson; Michael R Rosen
Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker.
Circulation 2006;114(10):992-9.
2006: Annalisa Bucchi; A Tognati; Raffaella Milanesi; Mirko Baruscotti; Dario DiFrancesco
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.
The Journal of physiology 2006;572(Pt 2):335-46.
2005: Mirko Baruscotti; Annalisa Bucchi; Dario DiFrancesco
Physiology and pharmacology of the cardiac pacemaker ("funny") current.
Pharmacology & therapeutics 2005;107(1):59-79.
2003: Annalisa Bucchi; Mirko Baruscotti; Richard B Robinson; Dario DiFrancesco
I(f)-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells.
Journal of molecular and cellular cardiology 2003;35(8):905-13.
2002: Jihong Qu; Claudia Altomare; Annalisa Bucchi; Dario DiFrancesco; Richard B Robinson
Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.
Pflügers Archiv : European journal of physiology 2002;444(5):597-601.
2002: Annalisa Bucchi; Mirko Baruscotti; Dario DiFrancesco
Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine.
The Journal of general physiology 2002;120(1):1-13.
2001: Carlo Viscomi; Claudia Altomare; Annalisa Bucchi; E Camatini; Mirko Baruscotti; Anna Moroni; Dario DiFrancesco
C terminus-mediated control of voltage and cAMP gating of hyperpolarization-activated cyclic nucleotide-gated channels.
The Journal of biological chemistry 2001;276(32):29930-4.
2001: Claudia Altomare; Annalisa Bucchi; E Camatini; Mirko Baruscotti; Carlo Viscomi; Anna Moroni; Dario DiFrancesco
Integrated allosteric model of voltage gating of HCN channels.
The Journal of general physiology 2001;117(6):519-32.