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luigi franchi

Research Profile

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Publications

TOP 3
V U Ozkurede; luigi franchi
Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes.
Seth L Masters; Aisling Dunne; Shoba L Subramanian; Rebecca L Hull; Gillian M Tannahill; Fiona A Sharp; Christine Becker; luigi franchi; Eiji Yoshihara; Zhe Chen; Niamh Mullooly; Lisa A Mielke; James Harris; Rebecca C Coll; Kingston H G Mills; K Hun Mok; Philip Newsholme; Gabriel Nuñez; Junji Yodoi; Steven E Kahn; E C Lavelle; Luke A J O'Neill
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Hana M Russo; Kevin J Wickenheiser; Wei Luo; Miina Ohman; luigi franchi; Andrew P Wright; Peter F Bodary; Gabriel Núñez; Núñez Gabriel; Daniel T Eitzman
P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue.

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All Publications

2012: V U Ozkurede; luigi franchi
Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes.
Clinical and experimental immunology 2012;167(3):382-90.
2010: Seth L Masters; Aisling Dunne; Shoba L Subramanian; Rebecca L Hull; Gillian M Tannahill; Fiona A Sharp; Christine Becker; luigi franchi; Eiji Yoshihara; Zhe Chen; Niamh Mullooly; Lisa A Mielke; James Harris; Rebecca C Coll; Kingston H G Mills; K Hun Mok; Philip Newsholme; Gabriel Nuñez; Junji Yodoi; Steven E Kahn; E C Lavelle; Luke A J O'Neill
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Nature immunology 2010;11(10):897-904.
2010: Hana M Russo; Kevin J Wickenheiser; Wei Luo; Miina Ohman; luigi franchi; Andrew P Wright; Peter F Bodary; Gabriel Núñez; Núñez Gabriel; Daniel T Eitzman
P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue.
Circulation research 2010;107(3):388-97.
2010: luigi franchi; Gabriel Nuñez
AIM2 joins the gang of microbial sensors.
Cell host & microbe 2010;7(5):340-1.
2010: Peter Duewell; Hajime Kono; Katey J Rayner; Cherilyn M Sirois; Gregory Vladimer; Franz G Bauernfeind; George S Abela; luigi franchi; Gabriel Nuñez; Max Schnurr; Terje Espevik; Egil Lien; Katherine A Fitzgerald; Kenneth L Rock; Kathryn J Moore; Samuel D Wright; Veit Hornung; Eicke Latz
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Nature 2010;464(7293):1357-61.
2010: luigi franchi; Raul Muñoz-Planillo; Thornik Reimer; Tatjana Eigenbrod; Gabriel Núñez
Inflammasomes as microbial sensors.
European journal of immunology 2010;40(3):611-5.
2010: Thornik Reimer; Michael H Shaw; luigi franchi; Cevayir Coban; Ken J Ishii; Shizuo Akira; Toshihiro Horii; Ana Rodriguez; Gabriel Núñez
Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome.
European journal of immunology 2010;40(3):764-9.
2009: Jürgen Harder; luigi franchi; Raúl Muñoz-Planillo; Jong-Hwan Park; Thornik Reimer; Gabriel Núñez
Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5823-9.
2009: Jessica Chu; L Michael Thomas; simon simon watkins; luigi franchi; Gabriel Núñez; Russell D Salter
Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner.
Journal of leukocyte biology 2009;86(5):1227-38.
2009: Raúl Muñoz-Planillo; luigi franchi; Lloyd S Miller; Gabriel Núñez
A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3942-8.
2009: luigi franchi; Tatjana Eigenbrod; Gabriel Núñez
Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):792-6.
2009: Lobelia Samavati; Ruchi Rastogi; Wenjin Du; Maik Huttemann; Alemu Fite; luigi franchi
STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria.
Molecular immunology 2009;46(8-9):1867-77.
2009: Yan Qu; Lakshmi Ramachandra; Susanne Mohr; luigi franchi; Clifford V Harding; Gabriel Nunez; George R Dubyak
P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):5052-62.
2009: Noemí Marina-García; luigi franchi; Yun-Gi Kim; Yonjun Hu; David E Smith; Gerardus Josephus Boons; Gabriel Núñez
Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4321-7.
2009: luigi franchi; Tatjana Eigenbrod; Raúl Muñoz-Planillo; Gabriel Nuñez
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.
Nature immunology 2009;10(3):241-7.
2009: Catherine Sanders; luigi franchi; Felix Yarovinsky; Satoshi Uematsu; Shizuo Akira; Gabriel Núñez; Andrew T Gewirtz
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity.
European journal of immunology 2009;39(2):359-71.
2009: luigi franchi; Grace Chen; Noemi Marina-Garcia; Akira Abe; Yan Qu; Shunzhong Bao; James A Shayman; John Turk; George R Dubyak; Gabriel Núñez
Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.
Journal of innate immunity 2009;1(6):607-17.
2009: luigi franchi; Neil Warner; Kyle Viani; Gabriel Nuñez
Function of Nod-like receptors in microbial recognition and host defense.
Immunological reviews 2009;227(1):106-28.
2008: Marco Radi; Lucilla Angeli; luigi franchi; Lorenzo Contemori; giovanni maga; Alberta Samuele; Samantha Zanoli; Mercedes Armand-Ugon; Emmanuel Gonzalez; Anuska Llano; José A Esté; Maurizio Botta
Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies.
Bioorganic & medicinal chemistry letters 2008;18(21):5777-80.
2008: luigi franchi; Gabriel Núñez
The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity.
European journal of immunology 2008;38(8):2085-9.
2008: Noemí Marina-García; luigi franchi; Yun-Gi Kim; Douglas Miller; Christine McDonald; Gerardus Josephus Boons; Gabriel Núñez
Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):4050-7.
2008: Yun-Gi Kim; Jong-Hwan Park; Michael H Shaw; luigi franchi; Naohiro Inohara; Gabriel Núñez
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.
Immunity 2008;28(2):246-57.
2008: luigi franchi; Jong-Hwan Park; Michael H Shaw; Noemi Marina-Garcia; Grace Chen; Yun-Gi Kim; Gabriel Núñez
Intracellular NOD-like receptors in innate immunity, infection and disease.
Cellular microbiology 2008;10(1):1-8.
2007: luigi franchi; Joshua Stoolman; Thirumala-Devi Kanneganti; Amrisha Verma; Reuben Ramphal; Gabriel Núñez
Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation.
European journal of immunology 2007;37(11):3030-9.
2007: Toshihiko Suzuki; luigi franchi; Claudia Toma; Hiroshi Ashida; Michinaga Ogawa; Yuko Yoshikawa; Hitomi Mimuro; Naohiro Inohara; Chihiro Sasakawa; Gabriel Nuñez
Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.
PLoS pathogens 2007;3(8):e111.
2007: Yan Qu; luigi franchi; Gabriel Nunez; George R Dubyak
Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1913-25.
2007: Mohamed Lamkanfi; Thirumala-Devi Kanneganti; luigi franchi; Gabriel Núñez
Caspase-1 inflammasomes in infection and inflammation.
Journal of leukocyte biology 2007;82(2):220-5.
2007: luigi franchi; Thirumala-Devi Kanneganti; George R Dubyak; Gabriel Núñez
Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria.
The Journal of biological chemistry 2007;282(26):18810-8.
2007: Thirumala-Devi Kanneganti; Mohamed Lamkanfi; Yun-Gi Kim; Grace Chen; Jong-Hwan Park; luigi franchi; Peter Vandenabeele; Gabriel Núñez
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.
Immunity 2007;26(4):433-43.
2006: Thirumala-Devi Kanneganti; Mathilde Body-Malapel; Amal Amer; Jong-Hwan Park; Joel Whitfield; luigi franchi; Zenobia F Taraporewala; David C Miller; John T Patton; Naohiro Inohara; Gabriel Núñez
Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA.
The Journal of biological chemistry 2006;281(48):36560-8.
2006: Amal Amer; luigi franchi; Thirumala-Devi Kanneganti; Mathilde Body-Malapel; Nesrin Ozören; Graham Brady; Sasha Meshinchi; Rajesh Jagirdar; Andrew T Gewirtz; Shizuo Akira; Gabriel Núñez
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.
The Journal of biological chemistry 2006;281(46):35217-23.
2006: Daniele Fina; luigi franchi; Roberta Caruso; Ilaria Peluso; Gian Carlo Naccari; Salvatore Bellinvia; Roberto Testi; Francesco Pallone; Giovanni Monteleone
5-aminosalicylic acid enhances anchorage-independent colorectal cancer cell death.
European journal of cancer (Oxford, England : 1990) 2006;42(15):2609-16.
2006: luigi franchi; Christine McDonald; Thirumala-Devi Kanneganti; Amal Amer; Gabriel Núñez
Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3507-13.
2006: luigi franchi; Amal Amer; Mathilde Body-Malapel; Thirumala-Devi Kanneganti; Nesrin Ozören; Rajesh Jagirdar; Naohiro Inohara; Peter Vandenabeele; John Bertin; Anthony J Coyle; Ethan P Grant; Gabriel Núñez
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.
Nature immunology 2006;7(6):576-82.
2006: Nesrin Ozören; Junya Masumoto; luigi franchi; Thirumala-Devi Kanneganti; Mathilde Body-Malapel; Ilkim Ertürk; Rajesh Jagirdar; Li Zhu; Naohiro Inohara; John Bertin; Anthony J Coyle; Ethan P Grant; Gabriel Núñez
Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4337-42.
2006: Thirumala-Devi Kanneganti; Nesrin Ozören; Mathilde Body-Malapel; Amal Amer; Jong-Hwan Park; luigi franchi; Joel Whitfield; Winfried Barchet; Marco COLONna; Peter Vandenabeele; John Bertin; Anthony J Coyle; Ethan P Grant; Shizuo Akira; Gabriel Núñez
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
Nature 2006;440(7081):233-6.
2006: Giovanni Monteleone; luigi franchi; Daniele Fina; Roberta Caruso; Piero Vavassori; Ivan Monteleone; Emma Calabrese; Gian Carlo Naccari; S Bellinvia; Roberto Testi; Francesco Pallone
Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells.
Cell death and differentiation 2006;13(2):202-11.
2006: luigi franchi; Florence Malisan; Barbara Tomassini; Roberto Testi
Ceramide catabolism critically controls survival of human dendritic cells.
Journal of leukocyte biology 2006;79(1):166-72.
2004: Barbara Tomassini; Florence Malisan; luigi franchi; Chiara Nicolò; Gloria Brea Calvo; Takashi Saito; Roberto Testi
Calnexin suppresses GD3 synthase-induced apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(13):1553-5.
2003: luigi franchi; Ivano Condò; Barbara Tomassini; Chiara Nicolò; Roberto Testi
A caspaselike activity is triggered by LPS and is required for survival of human dendritic cells.
Blood 2003;102(8):2910-5.
2002: Florence Malisan; luigi franchi; Barbara Tomassini; Natascia Ventura; Ivano Condò; Maria Rita Rippo; Alessandra Rufini; Laura Liberati; Claudia Nachtigall; Bernhard Kniep; Roberto Testi
Acetylation suppresses the proapoptotic activity of GD3 ganglioside.
The Journal of experimental medicine 2002;196(12):1535-41.
2002: luigi franchi; Roberto Testi
Is it cytotoxicity or apoptosis which causes cell death in autoimmunity?
Springer seminars in immunopathology 2002;24(3):331-41.