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DAVID WATKINS

Research Profile

Living Beings

Disorders

Physiology

Chemicals & Drugs

Anatomy

Genes & Molecular Sequences

Genes, Tumor Suppressor

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Publications

TOP 3
Nicholas J Clemons; Daniel Croagh; Christina M Fennell; Carmel Murone; Andrew M Scott; Anjali Tikoo; David H Wang; DAVID WATKINS; Wayne A Phillips
Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus.
Helai P Mohammad; H S Prevas; DAVID WATKINS; M Zhang; W Zhang; James G Herman; Craig M Hooker; David L Huso; Baktiar O Karim; B R Leadem; Stephen B Baylin
Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.
David H Wang; Nicholas J Clemons; Tomoharu Miyashita; Adam J Dupuy; Wei Zhang; Anette Szczepny; Ian M Corcoran-Schwartz; Daniel L Wilburn; Elizabeth Montgomery; JEAN WANG; Nancy A Jenkins; Neal A Copeland; John W Harmon; Wayne A Phillips; DAVID WATKINS
Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.

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All Publications

2012: Nicholas J Clemons; Daniel Croagh; Christina M Fennell; Carmel Murone; Andrew M Scott; Anjali Tikoo; David H Wang; DAVID WATKINS; Wayne A Phillips
Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(12):G1335-46.
2011: Helai P Mohammad; H S Prevas; DAVID WATKINS; M Zhang; W Zhang; James G Herman; Craig M Hooker; David L Huso; Baktiar O Karim; B R Leadem; Stephen B Baylin
Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.
Oncogene 2011;30(23):2659-69.
2010: David H Wang; Nicholas J Clemons; Tomoharu Miyashita; Adam J Dupuy; Wei Zhang; Anette Szczepny; Ian M Corcoran-Schwartz; Daniel L Wilburn; Elizabeth Montgomery; JEAN WANG; Nancy A Jenkins; Neal A Copeland; John W Harmon; Wayne A Phillips; DAVID WATKINS
Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.
Gastroenterology 2010;138(5):1810-22.
2010: W Zhang; X Zeng; K J Briggs; ROBERT BEATY; B Simons; R-W Chiu Yen; M A Tyler; H-C Tsai; Y Ye; G S Gesell; James G Herman; Stephen B Baylin; DAVID WATKINS
A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Oncogene 2010;29(17):2467-76.
2010: Benjamin Tang; Jie Fu; DAVID WATKINS; Justin Hanes
Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo.
Biomaterials 2010;31(2):339-44.
2009: Vincent C Daniel; LUIGI MARCHIONNI; Jared S Hierman; Jonathan T Rhodes; Wendy L Devereux; Charles Rudin; Rex C-W Yung; Giovanni Parmigiani; Marion Dorsch; CRAIG PEACOCK; DAVID WATKINS
A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro.
Cancer research 2009;69(8):3364-73.
2009: Tianyun Jiang; Brendan J Collins; Ning Jin; DAVID WATKINS; Malcolm V Brock; William Matsui; Barry D Nelkin; Douglas W Ball
Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer.
Cancer research 2009;69(3):845-54.
2008: Kimberly J Briggs; Charles G Eberhart; DAVID WATKINS
Just say no to ATOH: how HIC1 methylation might predispose medulloblastoma to lineage addiction.
Cancer research 2008;68(21):8654-6.
2008: CRAIG PEACOCK; DAVID WATKINS
Cancer stem cells and the ontogeny of lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(17):2883-9.
2008: Wei Zhang; Sabine C Glöckner; Mingzhou Guo; Emi Ota Machida; David H Wang; Hariharan Easwaran; Leander Van Neste; James G Herman; Kornel E Schuebel; DAVID WATKINS; NITA AHUJA; Stephen B Baylin
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer.
Cancer research 2008;68(8):2764-72.
2008: CHRISTINE HANN; Vincent C Daniel; Elizabeth Sugar; Irina Dobromilskaya; Sara C Murphy; Leslie Cope; Xue Lin; Jared S Hierman; Daniel L Wilburn; DAVID WATKINS; Charles Rudin
Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer.
Cancer research 2008;68(7):2321-8.
2008: Kimberly J Briggs; Ian M Corcoran-Schwartz; Wei Zhang; Thomas Harcke; Wendy L Devereux; Stephen B Baylin; Charles G Eberhart; DAVID WATKINS
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.
Genes & development 2008;22(6):770-85.
2008: Charles Rudin; CHRISTINE HANN; CRAIG PEACOCK; DAVID WATKINS
Novel systemic therapies for small cell lung cancer.
Journal of the National Comprehensive Cancer Network : JNCCN 2008;6(3):315-22.
2008: William Matsui; Qiuju Wang; James P Barber; Sarah Brennan; B Douglas Smith; Ivan Borrello; Ian K McNiece; Lan Lin; Richard F Ambinder; CRAIG PEACOCK; DAVID WATKINS; Carol Ann Huff; Richard J Jones
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance.
Cancer research 2008;68(1):190-7.
2007: P Seshidhar Reddy; Kevin D Burroughs; Laura M Hales; Shanthi Ganesh; Brian H Jones; Neeraja Idamakanti; Carl Hay; Shawn S Li; Kristine L Skele; Ann-Jeanette Vasko; Jingping Yang; DAVID WATKINS; Charles Rudin; Paul L Hallenbeck
Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers.
Journal of the National Cancer Institute 2007;99(21):1623-33.
2007: Wah K Lam; DAVID WATKINS
Lung cancer: future directions.
Respirology (Carlton, Vic.) 2007;12(4):471-7.
2007: Sandra A Biankin; Michael I Collector; Andrew V Biankin; Lindsey J Brown; Wolfram Kleeberger; Wendy L Devereux; Cynthia A Zahnow; Stephen B Baylin; DAVID WATKINS; Saul J Sharkis; Steven D Leach
A histological survey of green fluorescent protein expression in 'green' mice: implications for stem cell research.
Pathology 2007;39(2):247-51.
2007: CRAIG PEACOCK; Qiuju Wang; Gregory S Gesell; Ian M Corcoran-Schwartz; Evan Jones; Jynho Kim; Wendy L Devereux; Jonathan T Rhodes; Carol Ann Huff; Philip A Beachy; DAVID WATKINS; William Matsui
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4048-53.
2007: Joyce E Ohm; Kelly M McGarvey; Xiaobing Yu; Linzhao Cheng; Kornel E Schuebel; Leslie Cope; Helai P Mohammad; Wei Chen; Vincent C Daniel; Wayne Yu; berman david; Thomas Jenuwein; Kevin Pruitt; Saul J Sharkis; DAVID WATKINS; James G Herman; Stephen B Baylin
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
Nature genetics 2007;39(2):237-42.
2007: Nikolas Nikolaidis; Dimitra Chalkia; DAVID WATKINS; Roxanne K Barrow; Solomon H Snyder; Damian B van Rossum; Randen L Patterson
Ancient origin of the new developmental superfamily DANGER.
PloS one 2007;2(2):e204.
2006: Damian B van Rossum; Randen L Patterson; King-Ho Cheung; Roxanne K Barrow; Viktoriya Syrovatkina; Gregory S Gessell; Scott G Burkholder; DAVID WATKINS; J Kevin Foskett; Solomon H Snyder
DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity.
The Journal of biological chemistry 2006;281(48):37111-6.
2006: Vincent C Daniel; CRAIG PEACOCK; DAVID WATKINS
Developmental signalling pathways in lung cancer.
Respirology (Carlton, Vic.) 2006;11(3):234-40.
2006: Kevin Pruitt; Rebekah L Zinn; Joyce E Ohm; Kelly M McGarvey; Sung-Hae L Kang; DAVID WATKINS; James G Herman; Stephen B Baylin
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.
PLoS genetics 2006;2(3):e40.
2004: DAVID WATKINS; CRAIG PEACOCK
Hedgehog signalling in foregut malignancy.
Biochemical pharmacology 2004;68(6):1055-60.
2004: Hiromu Suzuki; DAVID WATKINS; Kam-Wing Jair; Kornel E Schuebel; Sanford D Markowitz; Wei Dong Chen; Theresa P Pretlow; Bin Yang; Yoshimitsu Akiyama; Manon van Engeland; Minoru Toyota; Takashi Tokino; Yuji Hinoda; Kohzoh Imai; James G Herman; Stephen B Baylin
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.
Nature genetics 2004;36(4):417-22.
2003: berman david; Sunil S Karhadkar; Anirban Maitra; Rocio Montes De Oca; Meg R Gerstenblith; Kimberly Briggs; Antony R Parker; Yutaka Shimada; James R Eshleman; DAVID WATKINS; Philip A Beachy
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.
Nature 2003;425(6960):846-51.
2003: DAVID WATKINS; berman david; Stephen B Baylin
Hedgehog signaling: progenitor phenotype in small-cell lung cancer.
Cell cycle (Georgetown, Tex.) 2003;2(3):196-8.
2003: DAVID WATKINS; berman david; Scott G Burkholder; Baolin Wang; Philip A Beachy; Stephen B Baylin
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
Nature 2003;422(6929):313-7.
2003: Wen Yong Chen; Xiaobei Zeng; Mark Carter; Craig N Morrell; Ray-Whay Chiu Yen; Manel Esteller; DAVID WATKINS; James G Herman; Joseph L Mankowski; Stephen B Baylin
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.
Nature genetics 2003;33(2):197-202.
2002: berman david; Sunil S Karhadkar; Andrew R Hallahan; Joel I Pritchard; Charles G Eberhart; DAVID WATKINS; James Kenneth Chen; Michael K Cooper; Jussi Taipale; James M Olson; Philip A Beachy
Medulloblastoma growth inhibition by hedgehog pathway blockade.
Science (New York, N.Y.) 2002;297(5586):1559-61.
2002: Virote Sriuranpong; Michael W Borges; Christopher L Strock; Eric K Nakakura; DAVID WATKINS; Christine M Blaumueller; Barry D Nelkin; Douglas W Ball
Notch signaling induces rapid degradation of achaete-scute homolog 1.
Molecular and cellular biology 2002;22(9):3129-39.
2002: S Ray; DAVID WATKINS; Neil Misso; Philip J Thompson
Oxidant stress induces gamma-glutamylcysteine synthetase and glutathione synthesis in human bronchial epithelial NCI-H292 cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(4):571-7.
2001: Eric K Nakakura; DAVID WATKINS; Virote Sriuranpong; Michael W Borges; Barry D Nelkin; Douglas W Ball
Mammalian Scratch participates in neuronal differentiation in P19 embryonal carcinoma cells.
Brain research. Molecular brain research 2001;95(1-2):162-6.
2001: Eleanor B Carson-Walter; DAVID WATKINS; Akash Nanda; Bert Vogelstein; Kenneth W Kinzler; Brad St Croix
Cell surface tumor endothelial markers are conserved in mice and humans.
Cancer research 2001;61(18):6649-55.
2001: Manel Esteller; C Cordon-Cardo; P G Corn; Meltzer Stephen J.; K S Pohar; DAVID WATKINS; Gabriel Capella; Miguel A Peinado; X Matias-Guiu; J Prat; Stephen B Baylin; James G Herman
p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2.
Cancer research 2001;61(7):2816-21.
2001: Eric K Nakakura; DAVID WATKINS; Kornel E Schuebel; Virote Sriuranpong; Michael W Borges; Barry D Nelkin; Douglas W Ball
Mammalian Scratch: a neural-specific Snail family transcriptional repressor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4010-5.
2000: Darryl A Knight; Nithiananthan Asokananthan; DAVID WATKINS; Neil Misso; Philip J Thompson; Geoffrey A Stewart
Oncostatin M synergises with house dust mite proteases to induce the production of PGE(2) from cultured lung epithelial cells.
British journal of pharmacology 2000;131(3):465-72.
2000: Manel Esteller; M Toyota; Montserrat Sanchez-Cespedes; Gabriel Capella; Miguel A Peinado; DAVID WATKINS; Jean-Pierre J Issa; David Sidransky; Stephen B Baylin; James G Herman
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Cancer research 2000;60(9):2368-71.
2000: Neil Misso; CRAIG PEACOCK; DAVID WATKINS; Philip J Thompson
Nitrite generation and antioxidant effects during neutrophil apoptosis.
Free radical biology & medicine 2000;28(6):934-43.
1999: DAVID WATKINS; J C Lenzo; A Segal; MJ Garlepp; P J Thompson
Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer.
The European respiratory journal 1999;14(2):412-8.
1999: CRAIG PEACOCK; Neil Misso; DAVID WATKINS; Philip J Thompson
PGE 2 and dibutyryl cyclic adenosine monophosphate prolong eosinophil survival in vitro.
The Journal of allergy and clinical immunology 1999;104(1):153-62.
1999: DAVID WATKINS; D J Peroni; J C Lenzo; D A Knight; MJ Garlepp; P J Thompson
Expression and localization of COX-2 in human airways and cultured airway epithelial cells.
The European respiratory journal 1999;13(5):999-1007.
1998: ML Taylor; MK Ilton; Neil Misso; DAVID WATKINS; Joseph Hung; PJ Thompson
The effect of aspirin on thrombin stimulated platelet adhesion receptor expression and the role of neutrophils.
British journal of clinical pharmacology 1998;46(2):139-45.
1998: DAVID WATKINS; R H Lewis; K A Basclain; P H Fisher; D J Peroni; MJ Garlepp; P J Thompson
Expression and localization of the inducible isoform of nitric oxide synthase in nasal polyp epithelium.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(2):211-9.
1998: Neil Misso; D J Peroni; DAVID WATKINS; Geoffrey A Stewart; Philip J Thompson
Glutathione peroxidase activity and mRNA expression in eosinophils and neutrophils of asthmatic and non-asthmatic subjects.
Journal of leukocyte biology 1998;63(1):124-30.
1997: DAVID WATKINS; MJ Garlepp; P J Thompson
Regulation of the inducible cyclo-oxygenase pathway in human cultured airway epithelial (A549) cells by nitric oxide.
British journal of pharmacology 1997;121(7):1482-8.
1997: DAVID WATKINS; D J Peroni; K A Basclain; MJ Garlepp; P J Thompson
Expression and activity of nitric oxide synthases in human airway epithelium.
American journal of respiratory cell and molecular biology 1997;16(6):629-39.
1995: Ian Jenkins; Peter V van Heerden; DAVID WATKINS
Cerebral lupus presenting a sepsis syndrome.
Anaesthesia and intensive care 1995;23(3):364-6.
1995: L P Wang; Ian Jenkins; DAVID WATKINS; S Chaudri
Antecubital central venous catheters revisited.
Anesthesia and analgesia 1995;80(1):211.
1994: R M Graham; M E Strahan; K W Norman; DAVID WATKINS; M J Sturm; Roger R Taylor
Platelet and plasma platelet-activating factor in sepsis and myocardial infarction.
Journal of lipid mediators and cell signalling 1994;9(2):167-82.
1993: DAVID WATKINS; Ian Jenkins; JM Rankin; G M Clarke
Inhaled nitric oxide in severe acute respiratory failure--its use in intensive care and description of a delivery system.
Anaesthesia and intensive care 1993;21(6):861-6.
1991: G L Cullingford; DAVID WATKINS; A D Watts; D F Mallon
Severe late postsplenectomy infection.
The British journal of surgery 1991;78(6):716-21.