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Florian Schelter; Bastian Seubert; Susanne Schaten; Carla Boccaccio; paolo comoglio; Michael Gerg; Martina Grandl; Stephanie Hauser; Achim Krüger
Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10.
Cristina Basilico; Addolorata Arnesano; Maria Galluzzo; paolo comoglio; Paolo Michieli
A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met.
Jose Rafael Sierra; Simona Corso; Luisa Caione; Virna Cepero; Paolo Conrotto; Alessandro Cignetti; Wanda Piacibello; Atsushi Kumanogoh; Hitoshi Kikutani; paolo comoglio; Luca Tamagnone; silvia giordano
Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages.

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All Publications

2011: Florian Schelter; Bastian Seubert; Susanne Schaten; Carla Boccaccio; paolo comoglio; Michael Gerg; Martina Grandl; Stephanie Hauser; Achim Krüger
Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10.
Clinical & experimental metastasis 2011;28(8):793-802.
2008: Cristina Basilico; Addolorata Arnesano; Maria Galluzzo; paolo comoglio; Paolo Michieli
A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met.
The Journal of biological chemistry 2008;283(30):21267-77.
2008: Jose Rafael Sierra; Simona Corso; Luisa Caione; Virna Cepero; Paolo Conrotto; Alessandro Cignetti; Wanda Piacibello; Atsushi Kumanogoh; Hitoshi Kikutani; paolo comoglio; Luca Tamagnone; silvia giordano
Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages.
The Journal of experimental medicine 2008;205(7):1673-85.
2008: paolo comoglio; silvia giordano; livio trusolino
Drug development of MET inhibitors: targeting oncogene addiction and expedience.
Nature reviews. Drug discovery 2008;7(6):504-16.
2008: Terumi Takahara; Feng Xue; Massimiliano Mazzone; Yutaka Yata; Kazunobu Nonome; Masami Kanayama; Kengo Kawai; Alberto M Pisacane; Shiro Takahara; Xiao-Kang Li; paolo comoglio; Toshiro Sugiyama; Paolo Michieli
Metron factor-1 prevents liver injury without promoting tumor growth and metastasis.
Hepatology (Baltimore, Md.) 2008;47(6):2010-25.
2008: Charlotte Rolny; Lorena Capparuccia; Andrea Casazza; Massimiliano Mazzone; Antonella Vallario; Alessandro Cignetti; Enzo Medico; Peter Carmeliet; paolo comoglio; Luca Tamagnone
The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment.
The Journal of experimental medicine 2008;205(5):1155-71.
2008: Alessandra Gentile; livio trusolino; paolo comoglio
The Met tyrosine kinase receptor in development and cancer.
Cancer metastasis reviews 2008;27(1):85-94.
2008: Simona Corso; C Migliore; E Ghiso; G De Rosa; paolo comoglio; silvia giordano
Silencing the MET oncogene leads to regression of experimental tumors and metastases.
Oncogene 2008;27(5):684-93.
2007: Silvia Benvenuti; paolo comoglio
The MET receptor tyrosine kinase in invasion and metastasis.
Journal of cellular physiology 2007;213(2):316-25.
2007: Sabrina Arena; Alberto Pisacane; Massimiliano Mazzone; paolo comoglio; Alberto Bardelli
Genetic targeting of the kinase activity of the Met receptor in cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11412-7.
2007: Andrea Rasola; Michela Fassetta; F De Bacco; Lorenza D'Alessandro; Daniela Gramaglia; Maria Flavia Di Renzo; paolo comoglio
A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth.
Oncogene 2007;26(7):1078-87.
2007: paolo comoglio; livio trusolino; Carla Boccaccio
Scatter factor-dependent branching morphogenesis: structural and histological features.
European journal of histochemistry : EJH 2007;51 Suppl 1():79-92.
2007: Pietro Fazzari; Junia Penachioni; Sara Gianola; Ferdinando Rossi; Britta J Eickholt; Flavio Maina; Lena Alexopoulou; Antonino Sottile; paolo comoglio; Richard A Flavell; Luca Tamagnone
Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis.
BMC developmental biology 2007;7():55.
2006: Andrea Bertotti; paolo comoglio; livio trusolino
Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth.
The Journal of cell biology 2006;175(6):993-1003.
2006: Massimiliano Mazzone; paolo comoglio
The Met pathway: master switch and drug target in cancer progression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1611-21.
2006: Carla Boccaccio; paolo comoglio
Invasive growth: a MET-driven genetic programme for cancer and stem cells.
Nature reviews. Cancer 2006;6(8):637-45.
2006: Nadia Coltella; Andrea Rasola; Elisa Nano; Chiara Bardella; Michela Fassetta; Nicoletta Filigheddu; Andrea Graziani; paolo comoglio; Maria Flavia Di Renzo
p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis.
International journal of cancer. Journal international du cancer 2006;118(12):2981-90.
2006: Salvatore Patanè; Sofia Avnet; Nadia Coltella; Barbara Costa; Simone Sponza; Martina Olivero; Elisa Vigna; Luigi Naldini; Nicola Baldini; Riccardo Ferracini; Simona Corso; silvia giordano; paolo comoglio; Maria Flavia Di Renzo
MET overexpression turns human primary osteoblasts into osteosarcomas.
Cancer research 2006;66(9):4750-7.
2006: Annalisa Petrelli; Paola Circosta; Luisa Granziero; Massimiliano Mazzone; Alberto Pisacane; Silvia Fenoglio; paolo comoglio; silvia giordano
Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):5090-5.
2005: Claudia Ghigna; Silvia Giordano; Haihong Shen; Federica Benvenuto; Fabio Castiglioni; paolo comoglio; Michael R Green; Silvano Riva; Giuseppe Biamonti
Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene.
Molecular cell 2005;20(6):881-90.
2005: Andrea Bertotti; paolo comoglio; livio trusolino
Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.
Cancer research 2005;65(23):10674-9.
2005: paolo comoglio; livio trusolino
Cancer: the matrix is now in control.
Nature medicine 2005;11(11):1156-9.
2005: Davide Barberis; Andrea Casazza; Raffaella Sordella; Simona Corso; Stefania Artigiani; Jeffrey Settleman; paolo comoglio; Luca Tamagnone
p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.
Journal of cell science 2005;118(Pt 20):4689-700.
2005: Carla Boccaccio; paolo comoglio
A functional role for hemostasis in early cancer development.
Cancer research 2005;65(19):8579-82.
2005: Claus Christensen; Noona Ambartsumian; Giorgio F Gilestro; Birthe Thomsen; paolo comoglio; Luca Tamagnone; Per Guldberg; Eugene Lukanidin
Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis.
Cancer research 2005;65(14):6167-77.
2005: Simona Corso; paolo comoglio; silvia giordano
Cancer therapy: can the challenge be MET?
Trends in molecular medicine 2005;11(6):284-92.
2005: Paolo Conrotto; Donatella Valdembri; Simona Corso; Guido Serini; Luca Tamagnone; paolo comoglio; Federico Bussolino; silvia giordano
Sema4D induces angiogenesis through Met recruitment by Plexin B1.
Blood 2005;105(11):4321-9.
2005: M Cristina Stella; livio trusolino; Selma Pennacchietti; paolo comoglio
Negative feedback regulation of Met-dependent invasive growth by Notch.
Molecular and cellular biology 2005;25(10):3982-96.
2005: Giorgio Valabrega; Filippo Montemurro; Ivana Sarotto; Annalisa Petrelli; Patrizia Rubini; Carlo Tacchetti; Massimo Aglietta; paolo comoglio; silvia giordano
TGFalpha expression impairs Trastuzumab-induced HER2 downregulation.
Oncogene 2005;24(18):3002-10.
2005: Carla Boccaccio; Gabriella Sabatino; Enzo Medico; Flavia Girolami; Antonia Follenzi; Gigliola Reato; Antonino Sottile; Luigi Naldini; paolo comoglio
The MET oncogene drives a genetic programme linking cancer to haemostasis.
Nature 2005;434(7031):396-400.
2004: paolo comoglio; Luca Tamagnone; Silvia Giordano
Invasive growth: a two-way street for semaphorin signalling.
Nature cell biology 2004;6(12):1155-7.
2004: Massimiliano Mazzone; Cristina Basilico; Silvia Cavassa; Selma Pennacchietti; Mauro Risio; Luigi Naldini; paolo comoglio; Paolo Michieli
An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice.
The Journal of clinical investigation 2004;114(10):1418-32.
2004: Chiara Bardella; Barbara Costa; Piera Maggiora; Salvatore Patane'; Martina Olivero; Guglielmina Nadia Ranzani; Michele De Bortoli; paolo comoglio; Maria Flavia Di Renzo
Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression.
Cancer research 2004;64(15):5154-61.
2004: Oliver M Fischer; Silvia Giordano; paolo comoglio; Axel Ullrich
Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells.
The Journal of biological chemistry 2004;279(28):28970-8.
2004: Paolo Michieli; Massimiliano Mazzone; Cristina Basilico; Silvia Cavassa; Antonino Sottile; Luigi Naldini; paolo comoglio
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.
Cancer cell 2004;6(1):61-73.
2004: Stefania Artigiani; Paolo Conrotto; Pietro Fazzari; Giorgio F Gilestro; Davide Barberis; silvia giordano; paolo comoglio; Luca Tamagnone
Plexin-B3 is a functional receptor for semaphorin 5A.
EMBO reports 2004;5(7):710-4.
2004: Paolo Conrotto; Simona Corso; Sara Gamberini; paolo comoglio; silvia giordano
Interplay between scatter factor receptors and B plexins controls invasive growth.
Oncogene 2004;23(30):5131-7.
2004: Luca Tamagnone; paolo comoglio
To move or not to move? Semaphorin signalling in cell migration.
EMBO reports 2004;5(4):356-61.
2004: Andrea Rasola; Sergio Anguissola; Norma Ferrero; Daniela Gramaglia; Antonella Maffe; Piera Maggiora; paolo comoglio; Maria Flavia Di Renzo
Hepatocyte growth factor sensitizes human ovarian carcinoma cell lines to paclitaxel and cisplatin.
Cancer research 2004;64(5):1744-50.
2004: Davide Barberis; Stefania Artigiani; Andrea Casazza; Simona Corso; silvia giordano; C A Love; E Y Jones; paolo comoglio; Luca Tamagnone
Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(3):592-4.
2004: Alessandra Gentile; paolo comoglio
Invasive growth: a genetic program.
The International journal of developmental biology 2004;48(5-6):451-6.
2003: Margarida Carrolo; silvia giordano; Laura Cabrita-Santos; Simona Corso; Ana Margarida Vigário; Susana Silva; Patrícia Leirião; Daniel Carapau; Rosario Armas-Portela; paolo comoglio; Ana Rodriguez; Maria M Mota
Hepatocyte growth factor and its receptor are required for malaria infection.
Nature medicine 2003;9(11):1363-9.
2003: Andrea Bertotti; paolo comoglio
Tyrosine kinase signal specificity: lessons from the HGF receptor.
Trends in biochemical sciences 2003;28(10):527-33.
2003: paolo comoglio; Carla Boccaccio; livio trusolino
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
Current opinion in cell biology 2003;15(5):565-71.
2003: Piera Maggiora; Annalisa Lorenzato; Stefano Fracchioli; Barbara Costa; Massimo Castagnaro; RICCARDO ARISIO; Dionyssios Katsaros; Marco Massobrio; paolo comoglio; Maria Flavia Di Renzo
The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness.
Experimental cell research 2003;288(2):382-9.
2003: Federica Chiara; Paolo Michieli; Luisa Pugliese; paolo comoglio
Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity.
The Journal of biological chemistry 2003;278(31):29352-8.
2003: Selma Pennacchietti; Paolo Michieli; Maria Galluzzo; Massimiliano Mazzone; silvia giordano; paolo comoglio
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.
Cancer cell 2003;3(4):347-61.
2003: Stefania Artigiani; Davide Barberis; Pietro Fazzari; Paola Longati; Paola Angelini; Jan-Willem van de Loo; paolo comoglio; Luca Tamagnone
Functional regulation of semaphorin receptors by proprotein convertases.
The Journal of biological chemistry 2003;278(12):10094-101.
2002: Annalisa Lorenzato; Martina Olivero; Salvatore Patanè; Edoardo Rosso; Alberto Oliaro; paolo comoglio; Maria Flavia Di Renzo
Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion.
Cancer research 2002;62(23):7025-30.
2002: silvia giordano; Simona Corso; Paolo Conrotto; Stefania Artigiani; Giorgio F Gilestro; Davide Barberis; Luca Tamagnone; paolo comoglio
The semaphorin 4D receptor controls invasive growth by coupling with Met.
Nature cell biology 2002;4(9):720-4.
2002: Paolo Michieli; Silvia Cavassa; Cristina Basilico; Annarita De Luca; Massimiliano Mazzone; Cinzia Asti; Riccardo Chiusaroli; Mario Guglielmi; Paola Bossù; Francesco Colotta; Gianfranco Caselli; paolo comoglio
An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity.
Nature biotechnology 2002;20(5):488-95.
2002: livio trusolino; paolo comoglio
Scatter-factor and semaphorin receptors: cell signalling for invasive growth.
Nature reviews. Cancer 2002;2(4):289-300.
2002: paolo comoglio; livio trusolino
Invasive growth: from development to metastasis.
The Journal of clinical investigation 2002;109(7):857-62.
2002: Annalisa Petrelli; Giorgio F Gilestro; Stefania Lanzardo; paolo comoglio; Nicola Migone; silvia giordano
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.
Nature 2002;416(6877):187-90.
2002: Raffaella De Maria; Piera Maggiora; Bartolomeo Biolatti; Maria Prat; paolo comoglio; Massimo Castagnaro; Maria Flavia Di Renzo
Feline STK gene expression in mammary carcinomas.
Oncogene 2002;21(11):1785-90.
2002: Carla Boccaccio; Margherita Ando'; paolo comoglio
A differentiation switch for genetically modified hepatocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(1):120-2.
2001: S Grisendi; B Chambraud; I Gout; paolo comoglio; crepaldi tiziana
Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor.
The Journal of biological chemistry 2001;276(49):46632-8.
2001: livio trusolino; Andrea Bertotti; paolo comoglio
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.
Cell 2001;107(5):643-54.
2001: ML Winberg; Luca Tamagnone; J Bai; paolo comoglio; Denise Montell; Corey S Goodman
The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance.
Neuron 2001;32(1):53-62.
2001: P Gual; silvia giordano; Sergio Anguissola; paolo comoglio
Differential requirement of the last C-terminal tail of Met receptor for cell transformation and invasiveness.
Oncogene 2001;20(39):5493-502.
2001: Enzo Medico; Alessandra Gentile; C Lo Celso; Tracy A Williams; Giovanna Gambarotta; livio trusolino; paolo comoglio
Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth.
Cancer research 2001;61(15):5861-8.
2001: paolo comoglio
Pathway specificity for Met signalling.
Nature cell biology 2001;3(7):E161-2.
2001: Enzo Medico; Giovanna Gambarotta; Alessandra Gentile; paolo comoglio; P Soriano
A gene trap vector system for identifying transcriptionally responsive genes.
Nature biotechnology 2001;19(6):579-82.
2001: M Cristina Stella; Alessandro Vercelli; Mariaelena Repici; Antonia Follenzi; paolo comoglio
Macrophage stimulating protein is a novel neurotrophic factor.
Molecular biology of the cell 2001;12(5):1341-52.
2001: paolo comoglio; C Boccaccio
Scatter factors and invasive growth.
Seminars in cancer biology 2001;11(2):153-65.
2001: Paola Longati; paolo comoglio; Alberto Bardelli
Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene.
Current drug targets 2001;2(1):41-55.
2001: Francesco Galimi; E Cottone; Elisa Vigna; Nicolò Arena; Carla Boccaccio; silvia giordano; Luigi Naldini; paolo comoglio
Hepatocyte growth factor is a regulator of monocyte-macrophage function.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1241-7.
2001: P Gual; silvia giordano; Sergio Anguissola; P J Parker; paolo comoglio
Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling.
Oncogene 2001;20(2):156-66.
2001: Andrea Rasola; Daniela Gramaglia; Carla Boccaccio; paolo comoglio
Apoptosis enhancement by the HIV-1 Nef protein.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):81-8.
2000: Giorgio Cortesina; Paola Rosso; P Mola; E Ricci; Andrea Luigi Cavalot; Tiziana Martone; paolo comoglio; Francesco Di Renzo
[Molecular markers study in pTNM of squamous carcinoma of the head and neck].
Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale 2000;20(6):380-2.
2000: Santina Cutrupi; Gianluca Baldanzi; Daniela Gramaglia; A Maffè; D Schaap; Enrico Giraudo; Wim J van Blitterswijk; Federico Bussolino; paolo comoglio; Andrea Graziani
Src-mediated activation of alpha-diacylglycerol kinase is required for hepatocyte growth factor-induced cell motility.
The EMBO journal 2000;19(17):4614-22.
2000: Luca Tamagnone; paolo comoglio
Signalling by semaphorin receptors: cell guidance and beyond.
Trends in cell biology 2000;10(9):377-83.
2000: livio trusolino; Silvia Cavassa; P Angelini; M Andó; Andrea Bertotti; paolo comoglio; Carla Boccaccio
HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1629-40.
2000: Antonia Follenzi; S Bakovic; P Gual; M Cristina Stella; Paola Longati; paolo comoglio
Cross-talk between the proto-oncogenes Met and Ron.
Oncogene 2000;19(27):3041-9.
2000: Giorgio Cortesina; Tiziana Martone; E Galeazzi; Martina Olivero; Antonella De Stefani; Mario Bussi; Guido Valente; paolo comoglio; Maria Flavia Di Renzo
Staging of head and neck squamous cell carcinoma using the MET oncogene product as marker of tumor cells in lymph node metastases.
International journal of cancer. Journal international du cancer 2000;89(3):286-92.
2000: Maria Flavia Di Renzo; Martina Olivero; Tiziana Martone; Antonella Maffe; Piera Maggiora; A D Stefani; Guido Valente; silvia giordano; Giorgio Cortesina; paolo comoglio
Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas.
Oncogene 2000;19(12):1547-55.
2000: P Gual; silvia giordano; Tracy A Williams; Stéphane Rocchi; Emmanuel Van Obberghen; paolo comoglio
Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.
Oncogene 2000;19(12):1509-18.
2000: silvia giordano; Antonella Maffe; Tracy A Williams; Stefania Artigiani; P Gual; Alberto Bardelli; Cristina Basilico; Paolo Michieli; paolo comoglio
Different point mutations in the met oncogene elicit distinct biological properties.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(2):399-406.
1999: M Cristina Stella; paolo comoglio
HGF: a multifunctional growth factor controlling cell scattering.
The international journal of biochemistry & cell biology 1999;31(12):1357-62.
1999: Stefania Scarpino; Antonella Stoppacciaro; Cristina Colarossi; F Cancellario; Antonella Marzullo; Maurizio Marchesi; Mauro Biffoni; paolo comoglio; Maria Prat; Luigi Ruco
Hepatocyte growth factor (HGF) stimulates tumour invasiveness in papillary carcinoma of the thyroid.
The Journal of pathology 1999;189(4):570-5.
1999: paolo comoglio; Luca Tamagnone; Carla Boccaccio
Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth.
Experimental cell research 1999;253(1):88-99.
1999: Stefania Artigiani; paolo comoglio; Luca Tamagnone
Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals?
IUBMB life 1999;48(5):477-82.
1999: Alberto Bardelli; Paola Longati; Tracy A Williams; Silvia Benvenuti; paolo comoglio
A peptide representing the carboxyl-terminal tail of the met receptor inhibits kinase activity and invasive growth.
The Journal of biological chemistry 1999;274(41):29274-81.
1999: Luca Tamagnone; Stefania Artigiani; H Chen; Z He; Guo-Li Ming; Hongjun Song; A Chedotal; ML Winberg; Corey S Goodman; M Poo; Marc Tessier-Lavigne; paolo comoglio
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.
Cell 1999;99(1):71-80.
1999: Paolo Michieli; Cristina Basilico; Selma Pennacchietti; A Maffè; Luca Tamagnone; silvia giordano; Alberto Bardelli; paolo comoglio
Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists.
Oncogene 1999;18(37):5221-31.
1999: Martina Olivero; Guido Valente; Alberto Bardelli; Paola Longati; Norma Ferrero; Cecilia Cracco; Carlo Terrone; Salvatore Rocca Rossetti; paolo comoglio; Maria Flavia Di Renzo
Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family.
International journal of cancer. Journal international du cancer 1999;82(5):640-3.
1999: Elisa Vigna; Daniela Gramaglia; Paola Longati; Alberto Bardelli; paolo comoglio
Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET.
Oncogene 1999;18(29):4275-81.
1999: Alberto Bardelli; M L Basile; Enrica Audero; silvia giordano; S Wennström; S Ménard; paolo comoglio; Carola Ponzetto
Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.
Oncogene 1999;18(5):1139-46.
1998: ML Winberg; Jasprina N Noordermeer; Luca Tamagnone; paolo comoglio; M K Spriggs; Marc Tessier-Lavigne; Corey S Goodman
Plexin A is a neuronal semaphorin receptor that controls axon guidance.
Cell 1998;95(7):903-16.
1998: Alberto Bardelli; Paola Longati; Daniela Gramaglia; Cristina Basilico; Luca Tamagnone; silvia giordano; D Ballinari; Paolo Michieli; paolo comoglio
Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14379-83.
1998: Emma Villa-Moruzzi; F Puntoni; Alberto Bardelli; Elisa Vigna; S De Rosa; paolo comoglio
Protein tyrosine phosphatase PTP-S binds to the juxtamembrane region of the hepatocyte growth factor receptor Met.
The Biochemical journal 1998;336 ( Pt 1)():235-9.
1998: A Zanetti; Antonella Stoppacciaro; Antonella Marzullo; M Ciabatta; F Fazioli; Maria Prat; paolo comoglio; Carlo Davide Baroni; Luigi Ruco
Expression of Met protein and urokinase-type plasminogen activator receptor (uPA-R) in papillary carcinoma of the thyroid.
The Journal of pathology 1998;186(3):287-91.
1998: livio trusolino; Luisa Pugliese; paolo comoglio
Interactions between scatter factors and their receptors: hints for therapeutic applications.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(13):1267-80.
1998: A Maffè; paolo comoglio
HGF controls branched morphogenesis in tubular glands.
European journal of morphology 1998;36 Suppl():74-81.
1998: Piera Maggiora; S Marchio; M Cristina Stella; Maurizia Giai; Antonino Belfiore; Michele De Bortoli; Maria Flavia Di Renzo; Angela Costantino; Piero Sismondi; paolo comoglio
Overexpression of the RON gene in human breast carcinoma.
Oncogene 1998;16(22):2927-33.
1998: Carla Boccaccio; M Andò; Luca Tamagnone; Alberto Bardelli; Paolo Michieli; C Battistini; paolo comoglio
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway.
Nature 1998;391(6664):285-8.
1998: M Prat; crepaldi tiziana; Selma Pennacchietti; Federico Bussolino; paolo comoglio
Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF.
Journal of cell science 1998;111 ( Pt 2)():237-47.
1997: Alberto Bardelli; Paola Longati; Daniela Gramaglia; M Cristina Stella; paolo comoglio
Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.
Oncogene 1997;15(25):3103-11.
1997: Alberto Bardelli; Luisa Pugliese; paolo comoglio
"Invasive-growth" signaling by the Met/HGF receptor: the hereditary renal carcinoma connection.
Biochimica et biophysica acta 1997;1333(3):M41-51.
1997: silvia giordano; Alberto Bardelli; Z Zhen; S Menard; Carola Ponzetto; paolo comoglio
A point mutation in the MET oncogene abrogates metastasis without affecting transformation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13868-72.
1997: Piera Maggiora; Giovanna Gambarotta; Martina Olivero; silvia giordano; Maria Flavia Di Renzo; paolo comoglio
Control of invasive growth by the HGF receptor family.
Journal of cellular physiology 1997;173(2):183-6.
1997: crepaldi tiziana; Alexis Gautreau; paolo comoglio; Daniel Louvard; Monique Arpin
Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells.
The Journal of cell biology 1997;138(2):423-34.
1997: Antonino Belfiore; Pietro Gangemi; Angela Costantino; G Russo; GM Santonocito; O Ippolito; Maria Flavia Di Renzo; paolo comoglio; Agata Fiumara; Riccardo Vigneri
Negative/low expression of the Met/hepatocyte growth factor receptor identifies papillary thyroid carcinomas with high risk of distant metastases.
The Journal of clinical endocrinology and metabolism 1997;82(7):2322-8.
1997: S Anastasi; silvia giordano; Olga Sthandier; Giovanna Gambarotta; Rossella Maione; paolo comoglio; Paolo Amati
A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiation.
The Journal of cell biology 1997;137(5):1057-68.
1997: Luca Tamagnone; paolo comoglio
Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors.
Cytokine & growth factor reviews 1997;8(2):129-42.
1997: Mircea Ivan; Jane A Bond; M Prat; paolo comoglio; David Wynford-Thomas
Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells.
Oncogene 1997;14(20):2417-23.
1997: Daniel Besser; Alberto Bardelli; S Didichenko; M Thelen; paolo comoglio; Carola Ponzetto; Yoshikuni Nagamine
Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2.
Oncogene 1997;14(6):705-11.
1997: Laura Amicone; Francesca M Spagnoli; GF Späth; silvia giordano; C Tommasini; S Bernardini; V De Luca; Carlo Della Rocca; Mary C Weiss; paolo comoglio; Marco Tripodi
Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes.
The EMBO journal 1997;16(3):495-503.
1997: Giovanni Camussi; Giuseppe Montrucchio; Enrico Lupia; R Soldi; paolo comoglio; Federico Bussolino
Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1302-9.
1997: Alberto Bardelli; paolo comoglio
Scatter factor receptors are key players in a unique multistep program leading to invasive growth.
Ciba Foundation symposium 1997;212():133-44; discussion 144-7.
1997: E Galeazzi; Martina Olivero; F C Gervasio; Antonella De Stefani; Guido Valente; paolo comoglio; Maria Flavia Di Renzo; Giorgio Cortesina
Detection of MET oncogene/hepatocyte growth factor receptor in lymph node metastases from head and neck squamous cell carcinomas.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 1997;254 Suppl 1():S138-43.
1996: Martina Olivero; M Rizzo; Roberto Madeddu; C Casadio; Selma Pennacchietti; Maria Rita Nicotra; M Prat; G Maggi; N Arena; P G Natali; paolo comoglio; Maria Flavia Di Renzo
Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas.
British journal of cancer 1996;74(12):1862-8.
1996: M M Santoro; C Collesi; S Grisendi; Giovanni Gaudino; paolo comoglio
Constitutive activation of the RON gene promotes invasive growth but not transformation.
Molecular and cellular biology 1996;16(12):7072-83.
1996: Alberto Bardelli; Paola Longati; D Albero; S Goruppi; C Schneider; Carola Ponzetto; paolo comoglio
HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.
The EMBO journal 1996;15(22):6205-12.
1996: Giovanna Gambarotta; Carla Boccaccio; silvia giordano; M Andŏ; M Cristina Stella; paolo comoglio
Ets up-regulates MET transcription.
Oncogene 1996;13(9):1911-7.
1996: Luigi Ruco; T Ranalli; A Marzullo; Paolo Bianco; M Prat; paolo comoglio; Carlo Davide Baroni
Expression of Met protein in thyroid tumours.
The Journal of pathology 1996;180(3):266-70.
1996: Flavio Maina; F Casagranda; Enrica Audero; A Simeone; paolo comoglio; Rudiger Klein; Carola Ponzetto
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development.
Cell 1996;87(3):531-42.
1996: Katia Scotlandi; Nicola Baldini; M Oliviero; Maria Flavia Di Renzo; M Martano; Massimo Serra; Maria Cristina Manara; paolo comoglio; R Ferracini
Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors.
The American journal of pathology 1996;149(4):1209-19.
1996: C Collesi; M M Santoro; Giovanni Gaudino; paolo comoglio
A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype.
Molecular and cellular biology 1996;16(10):5518-26.
1996: J Maier; M Mariotti; paolo comoglio; Marco Soria
Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells.
Oncogene 1996;13(5):1009-15.
1996: Maria Grano; Francesco Galimi; G Zambonin; Silvia Colucci; E Cottone; A Z Zallone; paolo comoglio
Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7644-8.
1996: P G Natali; M Prat; Maria Rita Nicotra; A Bigotti; Martina Olivero; paolo comoglio; Maria Flavia Di Renzo
Overexpression of the met/HGF receptor in renal cell carcinomas.
International journal of cancer. Journal international du cancer 1996;69(3):212-7.
1996: Carola Ponzetto; Z Zhen; Enrica Audero; Flavio Maina; Alberto Bardelli; M L Basile; silvia giordano; R Narsimhan; paolo comoglio
Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility.
The Journal of biological chemistry 1996;271(24):14119-23.
1996: R Ferracini; Martina Olivero; Maria Flavia Di Renzo; M Martano; Carla De Giovanni; Patrizia Nanni; G Basso; Katia Scotlandi; P L Lollini; paolo comoglio
Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas.
Oncogene 1996;12(8):1697-705.
1996: paolo comoglio; Carla Boccaccio
The HGF receptor family: unconventional signal transducers for invasive cell growth.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(4):347-54.
1996: E Medico; A M Mongiovi; J Huff; M A Jelinek; Antonia Follenzi; Giovanni Gaudino; Thomas J Parsons; paolo comoglio
The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro.
Molecular biology of the cell 1996;7(4):495-504.
1996: Andrea Graziani; Francesco Galimi; E Medico; E Cottone; Daniela Gramaglia; Carla Boccaccio; paolo comoglio
The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.
The Journal of biological chemistry 1996;271(12):6590-3.
1996: E Maestrini; Luca Tamagnone; Paola Longati; O Cremona; Massimo Gulisano; Silvia Bione; F Tamanini; B G Neel; Daniela Toniolo; paolo comoglio
A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):674-8.
1996: Paola Longati; D Albero; paolo comoglio
Hepatocyte growth factor is a pleiotropic factor protecting epithelial cells from apoptosis.
Cell death and differentiation 1996;3(1):23-8.
1995: Giovanni Gaudino; V Avantaggiato; Antonia Follenzi; D Acampora; A Simeone; paolo comoglio
The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.
Oncogene 1995;11(12):2627-37.
1995: F Silvagno; Antonia Follenzi; M Arese; M Prat; E Giraudo; Giovanni Gaudino; Giovanni Camussi; paolo comoglio; Federico Bussolino
In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(11):1857-65.
1995: Walter Franco Grigioni; Michelangelo Fiorentino; A D'Errico; A Ponzetto; crepaldi tiziana; M Prat; paolo comoglio
Overexpression of c-met protooncogene product and raised Ki67 index in hepatocellular carcinomas with respect to benign liver conditions.
Hepatology (Baltimore, Md.) 1995;21(6):1543-6.
1995: Maria Flavia Di Renzo; Richard Poulsom; Martina Olivero; paolo comoglio; Nick Lemoine
Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer.
Cancer research 1995;55(5):1129-38.
1995: R Ferracini; Maria Flavia Di Renzo; Katia Scotlandi; Nicola Baldini; Martina Olivero; P Lollini; O Cremona; M Campanacci; paolo comoglio
The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit.
Oncogene 1995;10(4):739-49.
1995: A J Ridley; paolo comoglio; Alan Hall
Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells.
Molecular and cellular biology 1995;15(2):1110-22.
1995: L Naldini; Elisa Vigna; Alberto Bardelli; Antonia Follenzi; Francesco Galimi; paolo comoglio
Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction.
The Journal of biological chemistry 1995;270(2):603-11.
1994: Francesco Galimi; Gian Paolo Bagnara; Laura Bonsi; E Cottone; Antonia Follenzi; A Simeone; paolo comoglio
Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors.
The Journal of cell biology 1994;127(6 Pt 1):1743-54.
1994: Alberto Bardelli; Carola Ponzetto; paolo comoglio
Identification of functional domains in the hepatocyte growth factor and its receptor by molecular engineering.
Journal of biotechnology 1994;37(2):109-22.
1994: Maria Flavia Di Renzo; Martina Olivero; Dionyssios Katsaros; crepaldi tiziana; P Gaglia; P Zola; Piero Sismondi; paolo comoglio
Overexpression of the Met/HGF receptor in ovarian cancer.
International journal of cancer. Journal international du cancer 1994;58(5):658-62.
1994: Giovanni Gaudino; Antonia Follenzi; L Naldini; C Collesi; M Santoro; Kathleen A Gallo; Paul J Godowski; paolo comoglio
RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.
The EMBO journal 1994;13(15):3524-32.
1994: Elisa Vigna; L Naldini; Luca Tamagnone; Paola Longati; Alberto Bardelli; Flavio Maina; Carola Ponzetto; paolo comoglio
Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene.
Cellular and molecular biology (Noisy-le-Grand, France) 1994;40(5):597-604.
1994: Z Zhen; silvia giordano; Paola Longati; E Medico; M Campiglio; paolo comoglio
Structural and functional domains critical for constitutive activation of the HGF-receptor (Met).
Oncogene 1994;9(6):1691-7.
1994: Giovanna Gambarotta; S Pistoi; silvia giordano; paolo comoglio; C Santoro
Structure and inducible regulation of the human MET promoter.
The Journal of biological chemistry 1994;269(17):12852-7.
1994: Carla Boccaccio; Giovanni Gaudino; Giovanna Gambarotta; Francesco Galimi; paolo comoglio
Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF.
The Journal of biological chemistry 1994;269(17):12846-51.
1994: Carola Ponzetto; Alberto Bardelli; Z Zhen; Flavio Maina; P dalla Zonca; silvia giordano; Andrea Graziani; G Panayotou; paolo comoglio
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family.
Cell 1994;77(2):261-71.
1994: crepaldi tiziana; A L Pollack; M Prat; A Zborek; K Mostov; paolo comoglio
Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells.
The Journal of cell biology 1994;125(2):313-20.
1994: Tatsuo Yamada; H Tsubouchi; Y Daikuhara; M Prat; paolo comoglio; Patrick L McGeer; Edith G McGeer
Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues.
Brain research 1994;637(1-2):308-12.
1994: L Gandino; Paola Longati; E Medico; M Prat; paolo comoglio
Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase.
The Journal of biological chemistry 1994;269(3):1815-20.
1994: crepaldi tiziana; M Prat; silvia giordano; E Medico; paolo comoglio
Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum.
The Journal of biological chemistry 1994;269(3):1750-5.
1994: Paola Longati; Alberto Bardelli; Carola Ponzetto; L Naldini; paolo comoglio
Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).
Oncogene 1994;9(1):49-57.
1993: Pier Giorgio Natali; Maria Rita Nicotra; Maria Flavia Di Renzo; M Prat; A Bigotti; R Cavaliere; paolo comoglio
Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression.
British journal of cancer 1993;68(4):746-50.
1993: Emma Villa-Moruzzi; S Lapi; M Prat; Giovanni Gaudino; paolo comoglio
A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor.
The Journal of biological chemistry 1993;268(24):18176-80.
1993: Carola Ponzetto; Alberto Bardelli; Flavio Maina; Paola Longati; G Panayotou; R Dhand; Michael D Waterfield; paolo comoglio
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor.
Molecular and cellular biology 1993;13(8):4600-8.
1993: Francesco Galimi; Maria Felice Brizzi; paolo comoglio
The hepatocyte growth factor and its receptor.
Stem cells (Dayton, Ohio) 1993;11 Suppl 2():22-30.
1993: Andrea Graziani; Daniela Gramaglia; P dalla Zonca; paolo comoglio
Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger.
The Journal of biological chemistry 1993;268(13):9165-8.
1993: F Buzzetti; M G Brasca; A Crugnola; S Fustinoni; A Longo; S Penco; P Dalla Zonca; paolo comoglio
Cinnamamide analogs as inhibitors of protein tyrosine kinases.
Farmaco (Società chimica italiana : 1989) 1993;48(5):615-36.
1993: silvia giordano; Z Zhen; E Medico; Giovanni Gaudino; Francesco Galimi; paolo comoglio
Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):649-53.
1993: Maria Flavia Di Renzo; Antonio Bertolotto; Martina Olivero; P Putzolu; crepaldi tiziana; D Schiffer; C A Pagni; paolo comoglio
Selective expression of the Met/HGF receptor in human central nervous system microglia.
Oncogene 1993;8(1):219-22.
1993: K M Weidner; Guido Hartmann; L Naldini; paolo comoglio; Martin Sachs; C Fonatsch; H Rieder; Walter Birchmeier
Molecular characteristics of HGF-SF and its role in cell motility and invasion.
EXS 1993;65():311-28.
1993: paolo comoglio
Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells.
EXS 1993;65():131-65.
1992: G Rege-Cambrin; P Scaravaglio; F Carozzi; silvia giordano; Carola Ponzetto; paolo comoglio; Giuseppe Saglio
Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene.
Cancer genetics and cytogenetics 1992;64(2):170-3.
1992: L Naldini; Luca Tamagnone; Elisa Vigna; Martin Sachs; Guido Hartmann; Walter Birchmeier; Y Daikuhara; H Tsubouchi; F Blasi; paolo comoglio
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
The EMBO journal 1992;11(13):4825-33.
1992: Guido Hartmann; L Naldini; K M Weidner; Martin Sachs; Elisa Vigna; paolo comoglio; Walter Birchmeier
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11574-8.
1992: Federico Bussolino; Maria Flavia Di Renzo; Marina Ziche; E Bocchietto; Martina Olivero; L Naldini; Giovanni Gaudino; Luca Tamagnone; A Coffer; paolo comoglio
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.
The Journal of cell biology 1992;119(3):629-41.
1992: silvia giordano; Maria Flavia Di Renzo; Martina Olivero; A Mondino; Z Zhen; E Medico; paolo comoglio
The c-met/HGF receptor in human tumours.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1992;1 Suppl 3():45-9.
1992: Alberto Bardelli; Flavio Maina; Ivan T Gout; M J Fry; Michael D Waterfield; paolo comoglio; Carola Ponzetto
Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains.
Oncogene 1992;7(10):1973-8.
1992: Salvatore Saccone; R P Narsimhan; Giovanni Gaudino; L Dalprà; paolo comoglio; G Della Valle
Regional mapping of the human hepatocyte growth factor (HGF)-scatter factor gene to chromosome 7q21.1.
Genomics 1992;13(3):912-4.
1991: M Prat; crepaldi tiziana; L Gandino; silvia giordano; Paola Longati; paolo comoglio
C-terminal truncated forms of Met, the hepatocyte growth factor receptor.
Molecular and cellular biology 1991;11(12):5954-62.
1991: A Mondino; silvia giordano; paolo comoglio
Defective posttranslational processing activates the tyrosine kinase encoded by the MET proto-oncogene (hepatocyte growth factor receptor).
Molecular and cellular biology 1991;11(12):6084-92.
1991: Andrea Graziani; Daniela Gramaglia; L C Cantley; paolo comoglio
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1991;266(33):22087-90.
1991: Maria Flavia Di Renzo; R P Narsimhan; Martina Olivero; S Bretti; silvia giordano; E Medico; P Gaglia; P Zara; paolo comoglio
Expression of the Met/HGF receptor in normal and neoplastic human tissues.
Oncogene 1991;6(11):1997-2003.
1991: R Ferracini; Paola Longati; L Naldini; Elisa Vigna; paolo comoglio
Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase.
The Journal of biological chemistry 1991;266(29):19558-64.
1991: M Prat; R P Narsimhan; crepaldi tiziana; M R Nicotra; Pier Giorgio Natali; paolo comoglio
The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors.
International journal of cancer. Journal international du cancer 1991;49(3):323-8.
1991: L Gandino; Luca Munaron; L Naldini; R Ferracini; M Magni; paolo comoglio
Intracellular calcium regulates the tyrosine kinase receptor encoded by the MET oncogene.
The Journal of biological chemistry 1991;266(24):16098-104.
1991: L Naldini; Elisa Vigna; R Ferracini; Paola Longati; L Gandino; M Prat; paolo comoglio
The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation.
Molecular and cellular biology 1991;11(4):1793-803.
1991: L Naldini; Elisa Vigna; R P Narsimhan; Giovanni Gaudino; R Zarnegar; G K Michalopoulos; paolo comoglio
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.
Oncogene 1991;6(4):501-4.
1991: Carola Ponzetto; silvia giordano; F Peverali; G Della Valle; M L Abate; Giovanna Vaula; paolo comoglio
c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase.
Oncogene 1991;6(4):553-9.
1991: M Prat; Maria Flavia Di Renzo; Giovanni Gaudino; Carola Ponzetto; paolo comoglio
Phosphotyrosine antibodies as probes for activated oncogene products endowed with tyrosine kinase activity.
Annali dell'Istituto superiore di sanità 1991;27(1):175-81.
1991: L Lehtola; L Sistonen; P Koskinen; H Lehväslaiho; M F Di Renzo; paolo comoglio; Kari Alitalo
Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation.
Journal of cellular biochemistry 1991;45(1):69-81.
1991: Carla Boccaccio; Giovanni Gaudino; Michele Cilli; A Mondino; paolo comoglio
Ligand-independent tyrosine phosphorylation of the receptor encoded by the c-neu oncogene.
Growth factors (Chur, Switzerland) 1991;5(3):233-42.
1990: Emmapaola Sturani; Renata Zippel; L Morello; R Brambilla; paolo comoglio; Lilia Alberghina
Kinetics of tyrosine phosphorylation and internalization of human EGF receptors overexpressed in NIH 3T3 fibroblasts.
Experimental cell research 1990;191(2):323-7.
1990: R De Castiglione; L Gozzini; R Mena; M Brugnolotti; M Ciomei; Isabella Molinari; paolo comoglio; Giovanni Gaudino
Bombesin receptor antagonists [corrected]. 1. Analogues with deleted, inverted or substituted amino acid residues.
Farmaco (Società chimica italiana : 1989) 1990;45(12):1251-63.
1990: paolo comoglio; Maria Flavia Di Renzo; Giovanni Gaudino; Carola Ponzetto; M Prat
Tyrosine kinase and control of cell proliferation.
The American review of respiratory disease 1990;142(6 Pt 2):S16-9.
1990: S Bretti; A P Cappa; paolo comoglio; Maria Flavia Di Renzo
[Tyrosine-phosphorylated proteins in human breast carcinoma].
The Journal of nuclear medicine and allied sciences 1990;34(4 Suppl):205-10.
1990: D Cirillo; L Naldini; Terry W Moody; paolo comoglio; Joseph Schlessinger; R Kris
Characterization of the detergent solubilized receptor for gastrin-releasing peptide.
Peptides 1990;11(4):737-45.
1990: L Naldini; D Cirillo; Terry W Moody; paolo comoglio; Joseph Schlessinger; R Kris
Solubilization of the receptor for the neuropeptide gastrin-releasing peptide (bombesin) with functional ligand binding properties.
Biochemistry 1990;29(21):5153-60.
1990: L Gandino; Maria Flavia Di Renzo; silvia giordano; Federico Bussolino; paolo comoglio
Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein.
Oncogene 1990;5(5):721-5.
1989: Renata Zippel; L Morello; R Brambilla; paolo comoglio; Lilia Alberghina; Emmapaola Sturani
Inhibition of phosphotyrosine phosphatases reveals candidate substrates of the PDGF receptor kinase.
European journal of cell biology 1989;50(2):428-34.
1989: silvia giordano; Maria Flavia Di Renzo; R P Narsimhan; C S Cooper; C Rosa; paolo comoglio
Biosynthesis of the protein encoded by the c-met proto-oncogene.
Oncogene 1989;4(11):1383-8.
1989: Lido Calorini; A Fallani; D Tombaccini; Emanuela Barletta; Gabriele Mugnai; M F Di Renzo; paolo comoglio; Salvatore Ruggieri
Lipid characteristics of RSV-transformed Balb/c 3T3 cell lines with different spontaneous metastatic potentials.
Lipids 1989;24(8):685-90.
1989: M Prat; E Medico; C Garrino; paolo comoglio
Biochemical and immunological properties of the human carcinoma antigen CAR-5 defined by the monoclonal antibody BD-5.
International journal of cancer. Journal international du cancer 1989;44(1):67-74.
1989: silvia giordano; Carola Ponzetto; Maria Flavia Di Renzo; C S Cooper; paolo comoglio
Tyrosine kinase receptor indistinguishable from the c-met protein.
Nature 1989;339(6220):155-6.
1989: M Prat; E Medico; P Rossino; C Garrino; paolo comoglio
Biochemical and immunological properties of the human carcinoma-associated CAR-3 epitope defined by the monoclonal antibody AR-3.
Cancer research 1989;49(6):1415-21.
1989: S Bretti; P Neri; Luisa Lozzi; M Rustici; paolo comoglio; Filippo G Giancotti; Guido Tarone
Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site.
International journal of cancer. Journal international du cancer 1989;43(1):102-6.
1989: Paola Brusa; F Pietribiasi; Gianni Bussolati; Franco Dosio; R Arione; paolo comoglio; M Prat; Luigi Cattel
Blocked and not blocked whole-ricin-antibody immunotoxins: intraperitoneal therapy of human tumour xenografted in nude mice.
Cancer immunology, immunotherapy : CII 1989;29(3):185-92.
1989: paolo comoglio
Growth factor receptors and class 1 oncogenes in cancer.
Animal genetics 1989;20(3):348-50.
1988: silvia giordano; Maria Flavia Di Renzo; R P Narsimhan; Luca Tamagnone; E V Gerbaudo; L Chiadó-Piat; paolo comoglio
Evidence for autocrine activation of a tyrosine kinase in a human gastric carcinoma cell line.
Journal of cellular biochemistry 1988;38(4):229-36.
1988: Renata Zippel; L Morello; L Toschi; Lilia Alberghina; paolo comoglio; Emmapaola Sturani
Effect of the growth conditions on the expression of cell-surface-associated platelet-derived growth factor receptors in mouse fibroblasts.
Biochimica et biophysica acta 1988;971(3):351-7.
1988: silvia giordano; Maria Flavia Di Renzo; R Ferracini; Loredana Chiadò-Piat; paolo comoglio
p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line.
Molecular and cellular biology 1988;8(8):3510-7.
1988: Pier Carlo Marchisio; N D'Urso; paolo comoglio; Filippo G Giancotti; Guido Tarone
Vanadate-treated baby hamster kidney fibroblasts show cytoskeleton and adhesion patterns similar to their Rous sarcoma virus-transformed counterparts.
Journal of cellular biochemistry 1988;37(2):151-9.
1988: Giovanni Gaudino; D Cirillo; L Naldini; P Rossino; paolo comoglio
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2166-70.
1988: Emmapaola Sturani; Renata Zippel; L Toschi; L Morello; paolo comoglio; Lilia Alberghina
Kinetics and regulation of the tyrosine phosphorylation of epidermal growth factor receptor in intact A431 cells.
Molecular and cellular biology 1988;8(3):1345-51.
1988: Luigi Cattel; L Delprino; Paola Brusa; Franco Dosio; paolo comoglio; M Prat
Comparison of blocked and non-blocked ricin-antibody immunotoxins against human gastric carcinoma and colorectal adenocarcinoma cell lines.
Cancer immunology, immunotherapy : CII 1988;27(3):233-40.
1988: paolo comoglio; Maria Flavia Di Renzo; R Ferracini; Giovanni Gaudino; silvia giordano
Detection of deregulated tyrosine-kinases in experimental and human metastatic tumors.
Advances in experimental medicine and biology 1988;233():303-8.
1988: M Prat; E Medico; P Piantino; S Bretti; F P Rossini; paolo comoglio
The monoclonal antibody-defined CAR-3 antigen is a serological marker associated with pancreatic carcinoma.
The International journal of biological markers 1988;3(1):29-35.
1988: Giovanni Gaudino; Michele Cilli; L Gandino; P Rossino; A Mondino; paolo comoglio
A tyrosine protein kinase activated by bombesin in normal fibroblasts and small cell carcinomas.
Annals of the New York Academy of Sciences 1988;547():293-302.
1987: Adriana Albini; G Allavena; A Melchiori; Filippo G Giancotti; H Richter; paolo comoglio; Stefano Parodi; G R Martin; Guido Tarone
Chemotaxis of 3T3 and SV3T3 cells to fibronectin is mediated through the cell-attachment site in fibronectin and a fibronectin cell surface receptor.
The Journal of cell biology 1987;105(4):1867-72.
1987: C B Underhill; Shawn Green; paolo comoglio; G Tarone
The hyaluronate receptor is identical to a glycoprotein of Mr 85,000 (gp85) as shown by a monoclonal antibody that interferes with binding activity.
The Journal of biological chemistry 1987;262(27):13142-6.
1987: M Prat; B Griselli; A Bernardi; P Rossino; G L Candelaresi; A P Cappa; paolo comoglio
Expression of the monoclonal antibody-defined CAR-3 epitope on neoplastic and preneoplastic lesions of the colon mucosa.
European journal of cancer & clinical oncology 1987;23(7):923-32.
1987: M Prat; S Bretti; M Amedeo; S Landolfo; paolo comoglio
Monoclonal antibodies against murine IFN-gamma abrogate in vivo tumor immunity against RSV-induced murine sarcomas.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(12):4530-3.
1987: silvia giordano; Maria Flavia Di Renzo; D Cirillo; L Naldini; L Chiado'Piat; paolo comoglio
Proteins phosphorylated on tyrosine as markers of human tumor cell lines.
International journal of cancer. Journal international du cancer 1987;39(4):482-7.
1987: M Prat; P Rossino; G Bussolati; I Morra; paolo comoglio
Production of monoclonal antibodies for the immunohistochemical detection of gastric carcinomas.
Cancer detection and prevention 1987;10(3-4):293-301.
1987: Filippo G Giancotti; paolo comoglio; Guido Tarone
Interaction of fibroblasts, hemopoietic cells and platelets with extracellular matrix: characterization and role of a common cell surface glycoprotein.
Annals of the New York Academy of Sciences 1987;511():65-76.
1987: G Gribaudo; F Di Renzo; L Naldini; paolo comoglio; G Cavallo; S Landolfo
Interferon-gamma inhibits cell replication, but not pp60src activity of RSV-transformed fibroblasts.
Microbiologica 1987;10(1):47-53.
1987: paolo comoglio; Maria Flavia Di Renzo; Giovanni Gaudino
Protein tyrosine kinases associated with human malignancies.
Annals of the New York Academy of Sciences 1987;511():256-61.
1986: D M Cirillo; Giovanni Gaudino; L Naldini; paolo comoglio
Receptor for bombesin with associated tyrosine kinase activity.
Molecular and cellular biology 1986;6(12):4641-9.
1986: A P Palumbo; P Rossino; paolo comoglio
Bombesin stimulation of c-fos and c-myc gene expression in cultures of Swiss 3T3 cells.
Experimental cell research 1986;167(1):276-80.
1986: Filippo G Giancotti; paolo comoglio; Guido Tarone
Fibronectin-plasma membrane interaction in the adhesion of hemopoietic cells.
The Journal of cell biology 1986;103(2):429-37.
1986: Maria Flavia Di Renzo; R Ferracini; L Naldini; silvia giordano; paolo comoglio
Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases.
European journal of biochemistry / FEBS 1986;158(2):383-91.
1986: Emmapaola Sturani; Lucia Maria Vicentini; Renata Zippel; L Toschi; A Pandiella-Alonso; paolo comoglio; J Meldolesi
PDGF-induced receptor phosphorylation and phosphoinositide hydrolysis are unaffected by protein kinase C activation in mouse Swiss 3T3 and human skin fibroblasts.
Biochemical and biophysical research communications 1986;137(1):343-50.
1986: L Naldini; A Stacchini; D M Cirillo; M Aglietta; F Gavosto; paolo comoglio
Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells.
Molecular and cellular biology 1986;6(5):1803-11.
1986: D Saggioro; R Ferracini; Maria Flavia Di Renzo; L Naldini; L Chieco-Bianchi; paolo comoglio
Protein phosphorylation at tyrosine residues in v-abl transformed mouse lymphocytes and fibroblasts.
International journal of cancer. Journal international du cancer 1986;37(4):623-8.
1986: Renata Zippel; Emmapaola Sturani; L Toschi; L Naldini; Lilia Alberghina; paolo comoglio
In vivo phosphorylation and dephosphorylation of the platelet-derived growth factor receptor studied by immunoblot analysis with phosphotyrosine antibodies.
Biochimica et biophysica acta 1986;881(1):54-61.
1986: Filippo G Giancotti; paolo comoglio; Guido Tarone
A 135,000 molecular weight plasma membrane glycoprotein involved in fibronectin-mediated cell adhesion. Immunofluorescence localization in normal and RSV-transformed fibroblasts.
Experimental cell research 1986;163(1):47-62.
1986: M Prat; G C Corbascio; P Rossino; F Tusco; paolo comoglio; Pier Carlo Marchisio
Production of a monoclonal antibody reacting with vimentin, a structural protein of intermediate filaments.
Basic and applied histochemistry 1986;30(4):417-24.
1985: M Prat; I Morra; G Bussolati; paolo comoglio
CAR-3, a monoclonal antibody-defined antigen expressed on human carcinomas.
Cancer research 1985;45(11 Pt 2):5799-807.
1985: Guido Tarone; D Cirillo; Filippo G Giancotti; paolo comoglio; P C Marchisio
Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes.
Experimental cell research 1985;159(1):141-57.
1985: Luisa Doneda; M F Di Renzo; paolo comoglio; Lidia Larizza
Role of heterochromatin variation in the instability of a marker chromosome during tumor progression.
Cancer genetics and cytogenetics 1985;15(3-4):283-91.
1985: paolo comoglio; M Prat; S Bretti
Enhancement of immunity against RSV-induced sarcomas by generation of hapten-reactive helper T lymphocytes.
Immunology 1985;54(2):289-95.
1985: M Prat; G Bussolati; M R Spinnato; paolo comoglio
Monoclonal antibodies against the human epidermoid carcinoma A 431.
Cancer detection and prevention 1985;8(1-2):169-79.
1985: D Saggioro; Maria Flavia Di Renzo; paolo comoglio; L Chieco-Bianchi
Different cellular substrates of Abelson leukemia virus transforming protein kinase in murine fibroblasts and lymphocytes.
Haematology and blood transfusion 1985;29():298-301.
1985: M F Di Renzo; G Tarone; paolo comoglio; P C Marchisio
Organization of cytoskeleton and fibronectin matrix in Rous sarcoma virus (RSV)-transformed fibroblast lines with different metastatic potential.
European journal of cancer & clinical oncology 1985;21(1):85-96.
1985: Filippo G Giancotti; Guido Tarone; K Knudsen; C Damsky; paolo comoglio
Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin.
Experimental cell research 1985;156(1):182-90.
1984: F Cofano; paolo comoglio; S Landolfo; G Tarone
Mouse immune interferon enhances fibronectin production of elicited macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(6):3102-6.
1984: D Cirillo; paolo comoglio; L Naldini; Pier Carlo Marchisio
Visualization of phosphotyrosine containing molecules within the detergent insoluble cell matrix of v-src transformed fibroblasts.
Cell biology international reports 1984;8(11):959-69.
1984: P C Marchisio; M F Di Renzo; paolo comoglio
Immunofluorescence localization of phosphotyrosine containing proteins in RSV-transformed mouse fibroblasts.
Experimental cell research 1984;154(1):112-24.
1984: Gérard Gacon; Remi Fagard; J P Boissel; S Fischer; L Reibel; J P Piau; G Schapira; paolo comoglio
Identification of a 58,000 daltons phosphoprotein with tyrosine protein kinase activity in a murine lymphoma cell line.
Biochemical and biophysical research communications 1984;122(2):563-70.
1984: M Prat; G Gribaudo; paolo comoglio; G Cavallo; S Landolfo
Monoclonal antibodies against murine gamma interferon.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(14):4515-9.
1984: paolo comoglio; Maria Flavia Di Renzo; Guido Tarone; Filippo G Giancotti; L Naldini; P C Marchisio
Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies.
The EMBO journal 1984;3(3):483-9.
1983: M Prat; M F Di Renzo; paolo comoglio
Characterization of T lymphocytes mediating in vivo protection against RSV-induced murine sarcomas.
International journal of cancer. Journal international du cancer 1983;31(6):757-64.
1983: M F Di Renzo; Luisa Doneda; Lidia Larizza; paolo comoglio
Metastatic clones selected from an RSV-induced mouse sarcoma share a common marker chromosome.
International journal of cancer. Journal international du cancer 1983;31(4):455-61.
1982: Guido Tarone; GIORGIO GALETTO; M Prat; paolo comoglio
Cell surface molecules and fibronectin-mediated cell adhesion: effect of proteolytic digestion of membrane proteins.
The Journal of cell biology 1982;94(1):179-86.
1982: R Ferracini; M Prat; paolo comoglio
Dissection of the antigenic determinants expressed on the cell surface of RSV-transformed fibroblasts by monoclonal antibodies.
International journal of cancer. Journal international du cancer 1982;29(4):477-81.
1982: M Bertini; GIORGIO GALETTO; paolo comoglio
Immune complexes and circulating antibodies against autologous leukaemic cells in patients with acute leukaemias.
Immunology 1982;45(3):569-75.
1981: G Tarone; P Ceschi; M Prat; paolo comoglio
Transformation-sensitive protein with molecular weight of 45,000 secreted by mouse fibroblasts.
Cancer research 1981;41(9 Pt 1):3648-52.
1981: M Prat; G Tarone; paolo comoglio
Mouse fibroblasts transformed by Rous sarcoma virus express a virus-specific non-virion transplantation antigen.
International journal of cancer. Journal international du cancer 1981;27(6):797-805.
1980: G Tarone; M Prat; paolo comoglio
Identification and partial characterization of five major membrane glycoproteins of BHK fibroblasts.
The Journal of membrane biology 1980;53(1):55-61.
1980: M Prat; F Tatò; Guido Tarone; paolo comoglio
Interaction between cellular and viral genes in the expression of the RSV-induced transformation-specific cell-surface antigen VCSA.
International journal of cancer. Journal international du cancer 1980;25(3):355-62.
1980: M Prat; F Tato; G Tarone; paolo comoglio
Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts.
Immunology 1980;39(2):179-85.