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Huiyuan Li

Research Profile

Chemicals & Drugs

Disorders

Alzheimer's Disease

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Cristian Ripoli; Huiyuan Li; Lucia Leone; Domenica D Li Puma; Roberto Piacentini; Elisa Riccardi; Claudio Grassi
Effects of different amyloid β-protein analogues on synaptic function.
Aida Attar; Sally A Frautschy; Greg D Gale; Claudio Grassi; Jane Hayes; Mychica R Jones; Frank-Gerrit Klärner; Domenica D Li Puma; Kristin Lichti-Kaiser; Tingyu Liu; Panchanan Maiti; Elisa Riccardi; Cristian Ripoli; Thomas Schrader; Jeffrey L Straudinger; Miao Tan; Chi-Hong Tseng; Cui-Wei Xie; Fusheng Yang; Huiyuan Li
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
Sharmistha Sinha; Dahabada H J Lopes; Huiyuan Li
A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity.

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All Publications

2013: Cristian Ripoli; Huiyuan Li; Lucia Leone; Domenica D Li Puma; Roberto Piacentini; Elisa Riccardi; Claudio Grassi
Effects of different amyloid β-protein analogues on synaptic function.
Neurobiology of aging 2013;34(4):1032-44.
2012: Aida Attar; Sally A Frautschy; Greg D Gale; Claudio Grassi; Jane Hayes; Mychica R Jones; Frank-Gerrit Klärner; Domenica D Li Puma; Kristin Lichti-Kaiser; Tingyu Liu; Panchanan Maiti; Elisa Riccardi; Cristian Ripoli; Thomas Schrader; Jeffrey L Straudinger; Miao Tan; Chi-Hong Tseng; Cui-Wei Xie; Fusheng Yang; Huiyuan Li
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
Brain : a journal of neurology 2012;135(Pt 12):3735-48.
2012: Sharmistha Sinha; Dahabada H J Lopes; Huiyuan Li
A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity.
ACS chemical neuroscience 2012;3(6):473-81.
2012: Sharmistha Sinha; Chunyu Wang; Zhenming Du; Frank-Gerrit Klärner; Panchanan Maiti; Thomas Schrader; Huiyuan Li
Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.
ACS chemical neuroscience 2012;3(6):451-8.
2012: Shubhangi Prabhudesai; Thomas Schrader; Sharmistha Sinha; Mark Stahl; Ravi Lakshmanan; Arthur G Fitzmaurice; Magdalena I Ivanova; Frank-Gerrit Klärner; Aswani Kotagiri; Rajeswari Lakshmanan; Joseph A Loo; Aida Attar; Huiyuan Li; Jeff M Bronstein
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2012;9(2):464-76.
2012: Tingyu Liu; Huiyuan Li
Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms.
ChemMedChem 2012;7(3):359-74.
2012: Huiyuan Li; Dahabada H J Lopes; Bernhard H Monien; Reeve Zemel; Huiyuan Li
A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors.
ChemMedChem 2012;7(3):515-22.
2012: Clark Rosensweig; Huiyuan Li; Devin K Lowenstein; Kazuma Murakami; Kenjiro Ono; David B Teplow
Preparation of stable amyloid β-protein oligomers of defined assembly order.
Methods in molecular biology (Clifton, N.J.) 2012;849():23-31.
2012: Dahabada H J Lopes; Clark Rosensweig; Sharmistha Sinha; Huiyuan Li
Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins.
Methods in molecular biology (Clifton, N.J.) 2012;849():11-21.
2011: Brigita Urbanc; M Betnel; Luis Cruz; E A Fradinger; H Li; B H Monien; Huiyuan Li
Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study.
Journal of molecular biology 2011;410(2):316-28.
2010: Huiyuan Li; Bernhard H Monien; Aleksey Lomakin; Reeve Zemel; Erica A Fradinger; Miao Tan; Sean M Spring; Brigita Urbanc; Cui-Wei Xie; George B. Benedek; Huiyuan Li
Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments.
Biochemistry 2010;49(30):6358-64.
2010: Huiyuan Li; Bernhard H Monien; Erica A Fradinger; Brigita Urbanc; Huiyuan Li
Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity.
Biochemistry 2010;49(6):1259-67.
2008: Erica A Fradinger; Bernhard H Monien; Brigita Urbanc; Aleksey Lomakin; Miao Tan; Huiyuan Li; Sean M Spring; Margaret M Condron; Luis Cruz; Cui-Wei Xie; George B. Benedek; Huiyuan Li
C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):14175-80.
2006: Huiyuan Li; Yi Jin; Christophe Morisseau; Bruce D Hammock; Ya-Qiu Long
The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase.
Bioorganic & medicinal chemistry 2006;14(19):6586-92.
2006: Huiyuan Li; Zahrah Zawahir; Lai-Dong Song; Ya-Qiu Long; Nouri Neamati
Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.
Journal of medicinal chemistry 2006;49(15):4477-86.
2006: Huiyuan Li
Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins.
Methods in enzymology 2006;413():217-36.
2005: Erica A Fradinger; Huiyuan Li
En route to early diagnosis of Alzheimer's disease--are we there yet?
Trends in biotechnology 2005;23(11):531-3.
2005: Yi Jin; Huiyuan Li; Li-Ping Lin; Jinzhi Tan; Jian Ding; Xiaomin Luo; Ya-Qiu Long
Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors.
Bioorganic & medicinal chemistry 2005;13(19):5613-22.
2005: Huiyuan Li; Erica A Fradinger; Sean M Spring; David B Teplow
Neurotoxic protein oligomers--what you see is not always what you get.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2005;12(2):88-95.
2005: Summer L Bernstein; Thomas Wyttenbach; Andrij Baumketner; Joan-Emma Shea; Huiyuan Li; David B Teplow; Michael T Bowers
Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.
Journal of the American Chemical Society 2005;127(7):2075-84.
2005: Sabrina S Vollers; David B Teplow; Huiyuan Li
Determination of Peptide oligomerization state using rapid photochemical crosslinking.
Methods in molecular biology (Clifton, N.J.) 2005;299():11-8.
2005: Huiyuan Li; David B Teplow
Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays.
Methods in molecular biology (Clifton, N.J.) 2005;299():3-9.
2004: Brigita Urbanc; Luis Cruz; S Yun; Sergey V Buldyrev; Huiyuan Li; David B Teplow; H Eugene Stanley
In silico study of amyloid beta-protein folding and oligomerization.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17345-50.
2004: Huiyuan Li; David B Teplow
Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies.
Accounts of chemical research 2004;37(6):357-64.
2003: Huiyuan Li; Bogdan Tarus; Sabrina S Vollers; Hilal A Lashuel; Margaret M Condron; John E Straub; David B Teplow
A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization.
Journal of the American Chemical Society 2003;125(50):15359-65.
2003: Huiyuan Li; Sabrina S Vollers; David B Teplow
Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.
The Journal of biological chemistry 2003;278(37):34882-9.
2003: Alon Monsonego; Victor Zota; Arnon Karni; Jeffrey I Krieger; Amit Bar-Or; Huiyuan Li; Andrew E Budson; Reisa Sperling; Dennis J Selkoe; Howard L Weiner
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease.
The Journal of clinical investigation 2003;112(3):415-22.
2003: Huiyuan Li; Marina D Kirkitadze; Aleksey Lomakin; Sabrina S Vollers; George B. Benedek; David B Teplow
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):330-5.
2002: Banghua Sun; Wei Fan; Aldona Balciunas; Jillian K Cooper; Huiyuan Li; Shirley Steavenson; Paul E Denis; Yunjen Young; Beverly Adler; Larry Daugherty; Raffi Manoukian; Gary Elliott; Wenyan Shen; Jane Talvenheimo; David B Teplow; Mitsuru Haniu; Raj Haldankar; Jette Wypych; Christopher A Ross; Martin Citron; William G Richards
Polyglutamine repeat length-dependent proteolysis of huntingtin.
Neurobiology of disease 2002;11(1):111-22.
2002: Marina D Kirkitadze; Huiyuan Li; David B Teplow
Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.
Journal of neuroscience research 2002;69(5):567-77.
2001: L Scheibler; DF Mierke; Huiyuan Li; Michael Rosenblatt; Michael Chorev
Identification of a contact domain between echistatin and the integrin alpha(v)beta(3) by photoaffinity cross-linking.
Biochemistry 2001;40(50):15117-26.
2001: Huiyuan Li; Aleksey Lomakin; David B Teplow
Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins.
The Journal of biological chemistry 2001;276(37):35176-84.
2000: Huiyuan Li; L Scheibler; H Teng; Michael Rosenblatt; Michael Chorev
Design and evaluation of benzophenone-containing conformationally constrained ligands as tools for photoaffinity scanning of the integrin alphaVbeta3-ligand bimolecular interaction.
The journal of peptide research : official journal of the American Peptide Society 2000;55(3):181-94.