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Maikel Peppelenbosch

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A van de Winkel; L J W van der Laan; Ernst J Kuipers; R Massl; Maikel Peppelenbosch
Digestive disease week 2011: highlights of clinical and preclinical research on Barrett's esophagus and associated esophageal adenocarcinoma.
R Somasundaram; C Janneke van der Woude; J J Deuring; Maikel Peppelenbosch; Gwenny M Fuhler
Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease.
Karla C S Queiroz; Roberta R Ruela-de-Sousa; C Arnold Spek; Willian F Zambuzzi; Sander H Diks; Nelson Duran; Carmen Veríssima Ferreira; Gwenny M Fuhler; Giselle Z Justo; Renato Milani; Maikel Peppelenbosch
Violacein induces death of resistant leukaemia cells via kinome reprogramming, endoplasmic reticulum stress and Golgi apparatus collapse.

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All Publications

2013: A van de Winkel; L J W van der Laan; Ernst J Kuipers; R Massl; Maikel Peppelenbosch
Digestive disease week 2011: highlights of clinical and preclinical research on Barrett's esophagus and associated esophageal adenocarcinoma.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E 2013;26(2):130-40.
2012: R Somasundaram; C Janneke van der Woude; J J Deuring; Maikel Peppelenbosch; Gwenny M Fuhler
Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease.
Gut 2012;61(7):1097; author reply 1097-8.
2012: Karla C S Queiroz; Roberta R Ruela-de-Sousa; C Arnold Spek; Willian F Zambuzzi; Sander H Diks; Nelson Duran; Carmen Veríssima Ferreira; Gwenny M Fuhler; Giselle Z Justo; Renato Milani; Maikel Peppelenbosch
Violacein induces death of resistant leukaemia cells via kinome reprogramming, endoplasmic reticulum stress and Golgi apparatus collapse.
PloS one 2012;7(10):e45362.
2012: Inge L Huibregtse; Martien L Kapsenberg; Maikel Peppelenbosch; Maria A Sartori da Silva; Sander J H van Deventer; Sebatian A Zaat; Henri Braat
Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells.
Gastroenterology research and practice 2012;2012():639291.
2011: Liudmila L Kodach; Hans Morreau; Maikel Peppelenbosch; Gijs R van den Brink; Tom van Wezel; Hein Verspaget; Philip W Voorneveld; Manon E Wildenberg; Daan W Hommes; Rutger J Jacobs; James C H Hardwick
Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.
Gut 2011;60(11):1544-53.
2011: Amy L Hazen; Sander H Diks; Gwenny M Fuhler; Maikel Peppelenbosch; Joseph A Wahle; William G Kerr
Major remodelling of the murine stem cell kinome following differentiation in the hematopoietic compartment.
Journal of proteome research 2011;10(8):3542-50.
2011: W van Veelen; S E Korsse; L van de Laar; Maikel Peppelenbosch
The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.
Oncogene 2011;30(20):2289-303.
2011: Zuzana Zelinkova; Colin de Haar; Lissy de Ridder; M J Pierik; Ernst J Kuipers; Maikel Peppelenbosch; C Janneke van der Woude
High intra-uterine exposure to infliximab following maternal anti-TNF treatment during pregnancy.
Alimentary pharmacology & therapeutics 2011;33(9):1053-8.
2011: Linda B C Bralten; Nanne K Kloosterhof; Rutger Balvers; Andrea Sacchetti; Lariesa Lapre; Martine Lamfers; Sieger Leenstra; Hugo R de Jonge; Johan M Kros; Erwin E W Jansen; Eduard A Struys; Cornelis Jakobs; Gajja S Salomons; Sander H Diks; Maikel Peppelenbosch; Andreas Kremer; Casper C Hoogenraad; Peter A E Sillevis Smitt; Pim J French
IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo.
Annals of neurology 2011;69(3):455-63.
2011: David J van Westerloo; Goda Choi; Ester C Löwenberg; Jasper Truijen; Alex F de Vos; Erik Endert; Joost C M Meijers; Lu Zhou; Manuel P F L Pereira; Karla C S Queiroz; Sander H Diks; Marcel Levi; Maikel Peppelenbosch; Tom van der Poll
Acute stress elicited by bungee jumping suppresses human innate immunity.
Molecular medicine (Cambridge, Mass.) 2011;17(3-4):180-8.
2011: Arja ter Elst; Sander H Diks; Kim R Kampen; Peter M Hoogerbrugge; Rob Ruijtenbeek; Piet J Boender; Arend H Sikkema; Frank J G Scherpen; Willem A Kamps; Maikel Peppelenbosch; Eveline S J M de Bont
Identification of new possible targets for leukemia treatment by kinase activity profiling.
Leukemia & lymphoma 2011;52(1):122-30.
2010: Karla C S Queiroz; R R Ruela-de-Sousa; Gwenny M Fuhler; H L Aberson; Carmen Veríssima Ferreira; Maikel Peppelenbosch; C Arnold Spek
Hedgehog signaling maintains chemoresistance in myeloid leukemic cells.
Oncogene 2010;29(48):6314-22.
2010: Keren Borensztajn; Paul Bresser; Chris M van der Loos; Ilze Bot; Bernt van den Blink; Michael A den Bakker; Joost Daalhuisen; Angelique P Groot; Maikel Peppelenbosch; Jan H von der Thüsen; C Arnold Spek
Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosis.
The American journal of pathology 2010;177(6):2753-64.
2010: Roberta R Ruela-de-Sousa; Karla C S Queiroz; Maikel Peppelenbosch; Gwenny M Fuhler
Reversible phosphorylation in haematological malignancies: potential role for protein tyrosine phosphatases in treatment?
Biochimica et biophysica acta 2010;1806(2):287-303.
2010: Karla C S Queiroz; Rene A Tio; Clark J Zeebregts; Maarten F Bijlsma; Felix Zijlstra; Bahram Badlou; Marcel de Vries; Carmen V Ferreira; C Arnold Spek; Maikel Peppelenbosch; Farhad Rezaee
Human plasma very low density lipoprotein carries Indian hedgehog.
Journal of proteome research 2010;9(11):6052-9.
2010: Gwenny M Fuhler; Mirjam Baanstra; Daniel Chesik; Rajesh Somasundaram; Anja Seckinger; Dirk Hose; Maikel Peppelenbosch; Nico A Bos
Bone marrow stromal cell interaction reduces syndecan-1 expression and induces kinomic changes in myeloma cells.
Experimental cell research 2010;316(11):1816-28.
2010: Keren Borensztajn; Maikel Peppelenbosch; C Arnold Spek
Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation.
Thrombosis research 2010;125(6):e323-8.
2010: Maria A Sartori da Silva; Jin-Ming Tee; Judith Paridaen; Anke Brouwers; Vincent Runtuwene; Danica Zivkovic; Sander H Diks; Daniele Guardavaccaro; Maikel Peppelenbosch
Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo.
PloS one 2010;5(11):e14023.
2009: K Borensztajn; Maikel Peppelenbosch; C A Spek
Letter in response to 'Coagulation and fibrosis in chronic liver disease'.
Gut 2009;58(11):1565-6.
2009: Arend H Sikkema; Sander H Diks; Wilfred F A den Dunnen; Arja ter Elst; Frank J G Scherpen; Eelco W Hoving; Rob Ruijtenbeek; Piet J Boender; Rik de Wijn; Willem A Kamps; Maikel Peppelenbosch; Eveline S J M de Bont
Kinome profiling in pediatric brain tumors as a new approach for target discovery.
Cancer research 2009;69(14):5987-95.
2009: Sali Al-Ansari; Clark J Zeebregts; Riemer H J A Slart; Maikel Peppelenbosch; René A Tio
Galectins in atherosclerotic disease.
Trends in cardiovascular medicine 2009;19(5):164-9.
2009: Keren Borensztajn; Maarten F Bijlsma; Pieter H Reitsma; Maikel Peppelenbosch; C Arnold Spek
Coagulation factor Xa inhibits cancer cell migration via protease-activated receptor-1 activation.
Thrombosis research 2009;124(2):219-25.
2009: Tita Ritsema; David Brodmann; Sander H Diks; Carina L Bos; Vinay Nagaraj; Corné M J Pieterse; Thomas Boller; Andres Wiemken; Maikel Peppelenbosch
Are small GTPases signal hubs in sugar-mediated induction of fructan biosynthesis?
PloS one 2009;4(8):e6605.
2009: Kaushal Parikh; Sander H Diks; Jurriaan H B Tuynman; Auke Verhaar; Mark Löwenberg; Daan W Hommes; Jos Joore; Akhilesh Pandey; Maikel Peppelenbosch
Comparison of peptide array substrate phosphorylation of c-Raf and mitogen activated protein kinase kinase kinase 8.
PloS one 2009;4(7):e6440.
2009: Kaushal Parikh; Maikel Peppelenbosch; Tita Ritsema
Kinome profiling using peptide arrays in eukaryotic cells.
Methods in molecular biology (Clifton, N.J.) 2009;527():269-80, x.
2009: L Zhou; Henri Braat; Klaas Nico Faber; G Dijkstra; Maikel Peppelenbosch
Monocytes and their pathophysiological role in Crohn's disease.
Cellular and molecular life sciences : CMLS 2009;66(2):192-202.
2009: Maikel Peppelenbosch; Carmen V Ferreira
Immunology of pre- and probiotic supplementation.
The British journal of nutrition 2009;101(1):2-4.
2008: Keren Borensztajn; Maikel Peppelenbosch; C Arnold Spek
Factor Xa: at the crossroads between coagulation and signaling in physiology and disease.
Trends in molecular medicine 2008;14(10):429-40.
2008: H H Versteeg; K S Borensztajn; M E Kerver; W Ruf; Pieter H Reitsma; C A Spek; Maikel Peppelenbosch
TF:FVIIa-specific activation of CREB upregulates proapoptotic proteins via protease-activated receptor-2.
Journal of thrombosis and haemostasis : JTH 2008;6(9):1550-7.
2008: Saravanan Yuvaraj; Saed Lahham; Ravi Marreddy; Gerard Dijkstra; Wout A M Wolken; Juke S Lolkema; Wijnand Helfrich; Finn-Erik Johansen; Maikel Peppelenbosch; Sa'ad Al-Lahham; Nicolaas A Bos
Human scFv SIgA expressed on Lactococcus lactis as a vector for the treatment of mucosal disease.
Molecular nutrition & food research 2008;52(8):913-20.
2008: Maarten F Bijlsma; Peter J A Leenders; Ben J A Janssen; Maikel Peppelenbosch; Hugo ten Cate; C Arnold Spek
Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury.
Experimental biology and medicine (Maywood, N.J.) 2008;233(8):989-96.
2008: Agnieszka M Rygiel; Francesca Milano; Fiebo J W Ten Kate; Annet Schaap; Kenneth K Wang; Maikel Peppelenbosch; Jacques J G H M Bergman; Kausilia K Krishnadath
Gains and amplifications of c-myc, EGFR, and 20.q13 loci in the no dysplasia-dysplasia-adenocarcinoma sequence of Barrett's esophagus.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(6):1380-5.
2008: Marcelo de Jesus; Willian Fernando Zambuzzi; Roberta Ruela de Sousa; Carlos Areche; Ana Carolina Santos de Souza; Hiroshi Aoyama; Guillermo Schmeda-Hirschmann; Jaime A Rodríguez; Alba Regina Monteiro de Souza Brito; Maikel Peppelenbosch; Jeroen den Hertog; Eneida de Paula; Carmen Veríssima Ferreira
Ferruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells.
Biochimie 2008;90(6):843-54.
2008: Liudmila L Kodach; Eliza Wiercinska; Noel F C C de Miranda; Sylvia A Bleuming; Alex R Musler; Maikel Peppelenbosch; Evelien Dekker; Gijs R van den Brink; Carel J M van Noesel; Hans Morreau; Daan W Hommes; Peter ten Dijke; G Johan A Offerhaus; James C H Hardwick
The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.
Gastroenterology 2008;134(5):1332-41.
2008: Maarten F Bijlsma; Maikel Peppelenbosch; C Arnold Spek; Henk Roelink
Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation.
Stem cells (Dayton, Ohio) 2008;26(5):1138-45.
2008: Agnieszka M Rygiel; Francesca Milano; Fiebo J W Ten Kate; John G de Groot; Maikel Peppelenbosch; Jacques J G H M Bergman; Kausilia K Krishnadath
Assessment of chromosomal gains as compared to DNA content changes is more useful to detect dysplasia in Barrett's esophagus brush cytology specimens.
Genes, chromosomes & cancer 2008;47(5):396-404.
2008: Jurriaan B Tuynman; Louis Vermeulen; Elles M Boon; Kristel Kemper; Aeilko H Zwinderman; Maikel Peppelenbosch; Dick J Richel
Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer.
Cancer research 2008;68(4):1213-20.
2008: Keren Borensztajn; Jurriën Stiekema; Sebastiaan Nijmeijer; Pieter H Reitsma; Maikel Peppelenbosch; C Arnold Spek
Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation.
The American journal of pathology 2008;172(2):309-20.
2008: Liudmila L Kodach; Sylvia A Bleuming; Alex R Musler; Maikel Peppelenbosch; Daan W Hommes; Gijs R van den Brink; Carel J M van Noesel; G Johan A Offerhaus; James C H Hardwick
The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer.
Cancer 2008;112(2):300-6.
2008: Jantine van Baal; Agnieszka M Rygiel; Francesca Milano; M Anderson; Jacques J G H M Bergman; C Arnold Spek; Kenneth K Wang; Maikel Peppelenbosch; Kausilia K Krishnadath
Gene expression profile comparison of Barrett's esophagus epithelial cell cultures and biopsies.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E 2008;21(7):628-33.
2008: Jantine van Baal; Andreas Bozikas; Rick Pronk; Fibo J W Ten Kate; Francesca Milano; Agnieszka M Rygiel; Wilda D Rosmolen; Maikel Peppelenbosch; Jacques J G H M Bergman; Kausilia K Krishnadath
Cytokeratin and CDX-2 expression in Barrett's esophagus.
Scandinavian journal of gastroenterology 2008;43(2):132-40.
2008: Jantine van Baal; Francesco Milana; Agnieszka M Rygiel; Carine M T Sondermeijer; C Arnold Spek; Jacques J G H M Bergman; Maikel Peppelenbosch; Kausilia K Krishnadath
A comparative analysis by SAGE of gene expression profiles of esophageal adenocarcinoma and esophageal squamous cell carcinoma.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2008;30(1):63-75.
2008: Maarten F Bijlsma; Maikel Peppelenbosch; C Arnold Spek
(Pro-)vitamin D as treatment option for hedgehog-related malignancies.
Medical hypotheses 2008;70(1):202-3.
2007: Karla Cristiana de Souza Queiroz; Willian Fernando Zambuzzi; Ana Carolina Santos de Souza; Rodrigo Augusto da Silva; Daisy Machado; Giselle Z Justo; Hernandes F Carvalho; Maikel Peppelenbosch; Carmen Veríssima Ferreira
A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours.
Cancer letters 2007;258(1):126-34.
2007: Maarten F Bijlsma; Keren S Borensztajn; Henk Roelink; Maikel Peppelenbosch; C Arnold Spek
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites.
Cellular signalling 2007;19(12):2596-604.
2007: Gerard Dijkstra; Saravanan Yuvaraj; Han-Qing Jiang; Judy C A M Bun; Han Moshage; Natasha Kushnir; Maikel Peppelenbosch; John J Cebra; Nicolaas A Bos
Early bacterial dependent induction of inducible nitric oxide synthase (iNOS) in epithelial cells upon transfer of CD45RB(high) CD4(+) T cells in a model for experimental colitis.
Inflammatory bowel diseases 2007;13(12):1467-74.
2007: Francesca Milano; Agnieszka M Rygiel; Navtej S Buttar; Jacques J G H M Bergman; Carine Sondermeijer; Jantine van Baal; Anja ten Brinke; Martien L Kapsenberg; S Marieke Van Ham; Maikel Peppelenbosch; Kausilia K Krishnadath
An ex vivo readout for evaluation of dendritic cell-induced autologous cytotoxic T lymphocyte responses against esophageal cancer.
Cancer immunology, immunotherapy : CII 2007;56(12):1967-77.
2007: Liudmila L Kodach; Sylvia A Bleuming; Maikel Peppelenbosch; Daan W Hommes; Gijs R van den Brink; James C H Hardwick
The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway.
Gastroenterology 2007;133(4):1272-81.
2007: Sylvia A Bleuming; Xi C He; Liudmila L Kodach; James C H Hardwick; Frieda A Koopman; Fiebo J W Ten Kate; Sander J H van Deventer; Daan W Hommes; Maikel Peppelenbosch; G Johan A Offerhaus; Linheng Li; Gijs R van den Brink
Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice.
Cancer research 2007;67(17):8149-55.
2007: Roberta R Ruela de Sousa; Karla Cristiana Souza Queiroz; Ana Carolina Santos Souza; Sonia A Gurgueira; Amanda Cavallari Augusto; Marcio André Miranda; Maikel Peppelenbosch; Carmen Veríssima Ferreira; Hiroshi Aoyama
Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):439-44.
2007: Keren S Borensztajn; Maarten F Bijlsma; Angelique P Groot; Lois W Brüggemann; Henri H Versteeg; Pieter H Reitsma; Maikel Peppelenbosch; C Arnold Spek
Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation.
Experimental cell research 2007;313(12):2622-33.
2007: Martin H de Borst; Sander H Diks; Juliane Bolbrinker; Mark Schellings; Mario B A van Dalen; Maikel Peppelenbosch; Reinhold Kreutz; Yigal M Pinto; gerjan navis; Harry van Goor
Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage.
American journal of physiology. Renal physiology 2007;293(1):F428-37.
2007: Francesca Milano; Jantine van Baal; Navtej S Buttar; Agnieszka M Rygiel; Floor de Kort; Cathrine J DeMars; Wilda D Rosmolen; Jacques J G H M Bergman; Jan VAn Marle; Kenneth K Wang; Maikel Peppelenbosch; Kausilia K Krishnadath
Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells.
Gastroenterology 2007;132(7):2412-21.
2007: Agnieszka M Rygiel; Jantine van Baal; Francesca Milano; Kenneth K Wang; Fiebo J W Ten Kate; Paul Fockens; Wilda D Rosmolen; Jacques J G H M Bergman; Maikel Peppelenbosch; Kausilia K Krishnadath
Efficient automated assessment of genetic abnormalities detected by fluorescence in situ hybridization on brush cytology in a Barrett esophagus surveillance population.
Cancer 2007;109(10):1980-8.
2007: Francesca Milano; Jantine van Baal; Agnieszka M Rygiel; Jacques J G H M Bergman; Sander J H van Deventer; Martien L Kapsenberg; Maikel Peppelenbosch; Kausilia K Krishnadath
An improved protocol for generation of immuno-potent dendritic cells through direct electroporation of CD14+ monocytes.
Journal of immunological methods 2007;321(1-2):94-106.
2007: Jan M H Van Den Brande; Tamara C Koehler; Zuzana Zelinkova; Roelof J Bennink; Anje A Te Velde; Fibo J W ten Cate; Sander J H van Deventer; Maikel Peppelenbosch; Daan W Hommes
Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease.
Gut 2007;56(4):509-17.
2007: Tom O'Toole; Maikel Peppelenbosch
Phosphatidyl inositol-3-phosphate kinase mediates CD14 dependent signaling.
Molecular immunology 2007;44(9):2362-9.
2007: Sander H Diks; Kaushal Parikh; Marijke van der Sijde; Jos Joore; Tita Ritsema; Maikel Peppelenbosch
Evidence for a minimal eukaryotic phosphoproteome?
PloS one 2007;2(8):e777.
2007: Jan M H Van Den Brande; Maikel Peppelenbosch; Daan W Hommes
Synergistic effect of methotrexate and infliximab on activated lymphocyte apoptosis.
Inflammatory bowel diseases 2007;13(1):118-9.
2007: Saravanan Yuvaraj; Maikel Peppelenbosch; Nicolaas A Bos
Transgenic probiotica as drug delivery systems: the golden bullet?
Expert opinion on drug delivery 2007;4(1):1-3.
2006: Cui-Ping Xu; Wen-Min Ji; Gijs R van den Brink; Maikel Peppelenbosch
Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver.
World journal of gastroenterology : WJG 2006;12(47):7621-5.
2006: Jantine van Baal; Sander H Diks; Ronald J A Wanders; Agnieszka M Rygiel; Francesca Milano; Jos Joore; Jacques J G H M Bergman; Maikel Peppelenbosch; Kausilia K Krishnadath
Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia.
Cancer research 2006;66(24):11605-12.
2006: Carmen Veríssima Ferreira; Giselle Z Justo; Ana C S Souza; Karla C S Queiroz; William F Zambuzzi; Hiroshi Aoyama; Maikel Peppelenbosch
Natural compounds as a source of protein tyrosine phosphatase inhibitors: application to the rational design of small-molecule derivatives.
Biochimie 2006;88(12):1859-73.
2006: Carina L Bos; Sander H Diks; James C H Hardwick; Kimberley V Walburg; Maikel Peppelenbosch; Dick J Richel
Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity.
Carcinogenesis 2006;27(12):2371-82.
2006: Maarten F Bijlsma; Maikel Peppelenbosch; C Arnold Spek
Hedgehog morphogen in cardiovascular disease.
Circulation 2006;114(18):1985-91.
2006: Carina L Bos; Liudmila L Kodach; Gijs R van den Brink; Sander H Diks; Marije M van Santen; Dick J Richel; Maikel Peppelenbosch; James C H Hardwick
Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A.
Oncogene 2006;25(49):6447-56.
2006: Jan M H Van Den Brande; Maikel Peppelenbosch; Daan W Hommes
Steroid-independent Crohn's disease patients also benefit from combination therapy of infliximab plus azathioprine.
Gastroenterology 2006;131(4):1362-3.
2006: Maarten F Bijlsma; Maikel Peppelenbosch; C Arnold Spek
A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling?
Development (Cambridge, England) 2006;133(20):3951; author reply 3952-3.
2006: Maarten F Bijlsma; C Arnold Spek; Maikel Peppelenbosch
Hedgehog turns lipoproteins into Janus-faced particles.
Trends in cardiovascular medicine 2006;16(7):217-20.
2006: Ana Carolina Santos de Souza; Liudmila Kodach; Fernanda R Gadelha; Carina L Bos; Alexandre D Martins Cavagis; Hiroshi Aoyama; Maikel Peppelenbosch; Carmen Veríssima Ferreira
A promising action of riboflavin as a mediator of leukaemia cell death.
Apoptosis : an international journal on programmed cell death 2006;11(10):1761-71.
2006: Mark Löwenberg; Auke Verhaar; Joyce Bilderbeek; Frank Buttgereit; Maikel Peppelenbosch; Sander J H van Deventer; Jan van Marle; Daan W Hommes
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.
EMBO reports 2006;7(10):1023-9.
2006: Mònica Comalada; Maikel Peppelenbosch
Impaired innate immunity in Crohn's disease.
Trends in molecular medicine 2006;12(9):397-9.
2006: Sander H Diks; Robert J Bink; Sandra van de Water; Jos Joore; Carina van Rooijen; Fons J Verbeek; Jeroen den Hertog; Maikel Peppelenbosch; Danica Zivkovic
The novel gene asb11: a regulator of the size of the neural progenitor compartment.
The Journal of cell biology 2006;174(4):581-92.
2006: Henri Braat; Maikel Peppelenbosch; Daan W Hommes
Immunology of Crohn's disease.
Annals of the New York Academy of Sciences 2006;1072():135-54.
2006: Maarten F Bijlsma; C Arnold Spek; Danica Zivkovic; Sandra van de Water; Farhad Rezaee; Maikel Peppelenbosch
Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.
PLoS biology 2006;4(8):e232.
2006: Mark Löwenberg; Meike Scheffer; Auke Verhaar; Maikel Peppelenbosch; Daan W Hommes
A role for STAT5 in steroid-resistant UC?
Inflammatory bowel diseases 2006;12(7):665.
2006: Mark Löwenberg; Jurriaan Tuynman; Meike Scheffer; Auke Verhaar; Louis Vermeulen; Sander J H van Deventer; Daan W Hommes; Maikel Peppelenbosch
Kinome analysis reveals nongenomic glucocorticoid receptor-dependent inhibition of insulin signaling.
Endocrinology 2006;147(7):3555-62.
2006: Henri Braat; Pieter Rottiers; Daan W Hommes; Nathalie Huyghebaert; Erik Remaut; Jean Paul Remon; Sander J H van Deventer; Sabine Neirynck; Maikel Peppelenbosch; Lothar Steidler
A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2006;4(6):754-9.
2006: Sylvia A Bleuming; Liudmila L Kodach; M J Garcia Leon; D J Richel; Maikel Peppelenbosch; P H Reitsma; James C H Hardwick; Gijs R van den Brink
Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach.
The Journal of pathology 2006;209(2):190-7.
2006: Liudmila L Kodach; Carina L Bos; Nelson Durán; Maikel Peppelenbosch; Carmen Veríssima Ferreira; James C H Hardwick
Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells.
Carcinogenesis 2006;27(3):508-16.
2006: Gijs R van den Brink; Maikel Peppelenbosch
Expression of hedgehog pathway components in the adult colon.
Gastroenterology 2006;130(2):619.
2006: Alexandre D Martins Cavagis; Carmen Veríssima Ferreira; Henri H Versteeg; Cristiane Fernandes Assis; Carina L Bos; Sylvia A Bleuming; Sander H Diks; Hiroshi Aoyama; Maikel Peppelenbosch
Tetrahydroxyquinone induces apoptosis of leukemia cells through diminished survival signaling.
Experimental hematology 2006;34(2):188-96.
2006: Mark Löwenberg; Maikel Peppelenbosch; Daan W Hommes
Biological therapy in the management of recent-onset Crohn's disease: why, when and how?
Drugs 2006;66(11):1431-9.
2005: Jantine van Baal; Francesca Milano; Agnieszka M Rygiel; Jacques J G H M Bergman; Wilda D Rosmolen; Sander J H van Deventer; Kenneth K Wang; Maikel Peppelenbosch; Kausilia K Krishnadath
A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia.
Gastroenterology 2005;129(4):1274-81.
2005: Mark Löwenberg; Jurriaan Tuynman; Joyce Bilderbeek; Timo Gaber; Frank Buttgereit; Sander J H van Deventer; Maikel Peppelenbosch; Daan W Hommes
Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn.
Blood 2005;106(5):1703-10.
2005: Mark Löwenberg; Auke Verhaar; Bernt van den Blink; Fibo ten Kate; Sander J H van Deventer; Maikel Peppelenbosch; Daan W Hommes
Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2293-300.
2005: Henri Braat; Pieter C F Stokkers; Tijmen Hommes; Danny Cohn; Esther Vogels; Inge Pronk; Arnold Spek; Antoine H C van Kampen; Sander J H van Deventer; Maikel Peppelenbosch; Daan W Hommes
Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients.
Journal of molecular medicine (Berlin, Germany) 2005;83(8):601-9.
2005: Jan M H Van Den Brande; Daan W Hommes; Maikel Peppelenbosch
Infliximab induced T lymphocyte apoptosis in Crohn's disease.
The Journal of rheumatology. Supplement 2005;74():26-30.
2004: Henri Braat; Jan M H Van Den Brande; Erik van Tol; Daan W Hommes; Maikel Peppelenbosch; Sander J H van Deventer
Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function.
The American journal of clinical nutrition 2004;80(6):1618-25.
2004: Sander H Diks; Maikel Peppelenbosch
Single cell proteomics for personalised medicine.
Trends in molecular medicine 2004;10(12):574-7.
2004: Sander H Diks; Klaartje Kok; Tom O'Toole; Daan W Hommes; Peter van Dijken; Jos Joore; Maikel Peppelenbosch
Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells.
The Journal of biological chemistry 2004;279(47):49206-13.
2004: Jurriaan B Tuynman; Maikel Peppelenbosch; Dick J Richel
COX-2 inhibition as a tool to treat and prevent colorectal cancer.
Critical reviews in oncology/hematology 2004;52(2):81-101.
2004: Maikel Peppelenbosch; Sander J H van Deventer
T cell apoptosis and inflammatory bowel disease.
Gut 2004;53(11):1556-8.
2004: Carmen Veríssima Ferreira; Carina L Bos; Henri H Versteeg; Giselle Z Justo; Nelson Durán; Maikel Peppelenbosch
Molecular mechanism of violacein-mediated human leukemia cell death.
Blood 2004;104(5):1459-64.
2004: Carina L Bos; Dick J Richel; Tita Ritsema; Maikel Peppelenbosch; Henri H Versteeg
Prostanoids and prostanoid receptors in signal transduction.
The international journal of biochemistry & cell biology 2004;36(7):1187-205.
2004: James C H Hardwick; Marije M van Santen; Gijs R van den Brink; Sander J H van Deventer; Maikel Peppelenbosch
DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1.
Carcinogenesis 2004;25(7):1293-8.
2004: Henri H Versteeg; C Arnold Spek; Sjoukje H Slofstra; Sander H Diks; Dick J Richel; Maikel Peppelenbosch
FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production.
Circulation research 2004;94(8):1032-40.
2004: Henri H Versteeg; Dick J Richel; Maikel Peppelenbosch; C Arnold Spek
Concerted action of coagulation factors on cell survival.
Journal of thrombosis and haemostasis : JTH 2004;2(4):673-4.
2004: Maarten F Bijlsma; C Arnold Spek; Maikel Peppelenbosch
Hedgehog: an unusual signal transducer.
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(4):387-94.
2004: Gijs R van den Brink; Sylvia A Bleuming; James C H Hardwick; Berber L Schepman; G Johan A Offerhaus; Josbert J Keller; Corinne Nielsen; William Gaffield; Sander J H van Deventer; Drucilla J Roberts; Maikel Peppelenbosch
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.
Nature genetics 2004;36(3):277-82.
2004: Henri Braat; Esther C de Jong; Jan M H Van Den Brande; Martien L Kapsenberg; Maikel Peppelenbosch; Eric A F van Tol; Sander J H van Deventer
Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function.
Journal of molecular medicine (Berlin, Germany) 2004;82(3):197-205.
2004: Mark Löwenberg; Maikel Peppelenbosch; Daan W Hommes
Therapeutic modulation of signal transduction pathways.
Inflammatory bowel diseases 2004;10 Suppl 1():S52-7.
2004: Sylvia A Bleuming; Maikel Peppelenbosch; Drucilla J Roberts; Gijs R van den Brink
Homeostasis of the adult colonic epithelium: a role for morphogens.
Scandinavian journal of gastroenterology 2004;39(2):93-8.
2004: Henri H Versteeg; C Arnold Spek; Dick J Richel; Maikel Peppelenbosch
Coagulation factors VIIa and Xa inhibit apoptosis and anoikis.
Oncogene 2004;23(2):410-7.
2004: Henri H Versteeg; C Arnold Spek; Maikel Peppelenbosch; Dick J Richel
Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways.
Molecular medicine (Cambridge, Mass.) 2004;10(1-6):6-11.
2004: Sander H Diks; Dick J Richel; Maikel Peppelenbosch
LPS signal transduction: the picture is becoming more complex.
Current topics in medicinal chemistry 2004;4(11):1115-26.
2004: Bernt van den Blink; Judith Branger; Sebastiaan Weijer; Abhya Gupta; Sander J H van Deventer; Maikel Peppelenbosch; Tom van der Poll
P38 mitogen activated protein kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia.
Journal of clinical immunology 2004;24(1):37-41.
2004: James C H Hardwick; Gijs R van den Brink; Sylvia A Bleuming; Isabel Ballester; Jan M H Van Den Brande; Josbert J Keller; G Johan A Offerhaus; Sander J H van Deventer; Maikel Peppelenbosch
Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon.
Gastroenterology 2004;126(1):111-21.
2003: Sander H Diks; James C H Hardwick; Remco M Diab; Marije M van Santen; Henri H Versteeg; Sander J H van Deventer; Dick J Richel; Maikel Peppelenbosch
Activation of the canonical beta-catenin pathway by histamine.
The Journal of biological chemistry 2003;278(52):52491-6.
2003: Henri Braat; Maikel Peppelenbosch; Daan W Hommes
Interleukin-10-based therapy for inflammatory bowel disease.
Expert opinion on biological therapy 2003;3(5):725-31.
2003: Henri H Versteeg; Maikel Peppelenbosch; C Arnold Spek
Tissue factor signal transduction in angiogenesis.
Carcinogenesis 2003;24(6):1009-13.
2003: Jan M H Van Den Brande; Henri Braat; Gijs R van den Brink; Henri H Versteeg; Christiaan A Bauer; Inge Hoedemaeker; Catherine van Montfrans; Daan W Hommes; Maikel Peppelenbosch; Sander J H van Deventer
Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease.
Gastroenterology 2003;124(7):1774-85.
2003: Judith Branger; Bernt van den Blink; Sebastiaan Weijer; Abhya Gupta; Sander J H van Deventer; C Erik Hack; Maikel Peppelenbosch; Tom van der Poll
Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia.
Blood 2003;101(11):4446-8.
2003: Henri H Versteeg; H L Bresser; C Arnold Spek; Dick J Richel; Sander J H van Deventer; Maikel Peppelenbosch
Regulation of the p21Ras-MAP kinase pathway by factor VIIa.
Journal of thrombosis and haemostasis : JTH 2003;1(5):1012-8.
2003: Maikel Peppelenbosch; Henri H Versteeg; C Arnold Spek
In silico tissue factor analysis: a bit-to-bit comparison.
Thrombosis and haemostasis 2003;89(3):592-3.
2003: Daan W Hommes; Maikel Peppelenbosch; Sander J H van Deventer
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets.
Gut 2003;52(1):144-51.
2002: Maikel Peppelenbosch; C Arnold Spek
Type I diabetes: a role for tissue factor in pancreatic islet transplantation?
Lancet 2002;360(9350):1999-2000.
2002: Walter L Vervenne; Carina L Bos; Linda S Rens; Maikel Peppelenbosch; Dick J Richel
Farnesyl protein transferase inhibition interferes with activation of MAP kinase family members in human peripheral blood monocytes.
Molecular medicine (Cambridge, Mass.) 2002;8(12):857-62.
2002: Bernt van den Blink; Tessa ten Hove; Gijs R van den Brink; Maikel Peppelenbosch; Sander J H van Deventer
From extracellular to intracellular targets, inhibiting MAP kinases in treatment of Crohn's disease.
Annals of the New York Academy of Sciences 2002;973():349-58.
2002: Jan M H Van Den Brande; Maikel Peppelenbosch; Sander J H van Deventer
Treating Crohn's disease by inducing T lymphocyte apoptosis.
Annals of the New York Academy of Sciences 2002;973():166-80.
2002: Arnon P Kater; Maikel Peppelenbosch; D P M Brandjes; Mika Lumbantobing
Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction.
Clinical and diagnostic laboratory immunology 2002;9(6):1396-7.
2002: Gijs R van den Brink; James C H Hardwick; C Nielsen; C Xu; Fiebo J W Ten Kate; J Glickman; Sander J H van Deventer; Drucilla J Roberts; Maikel Peppelenbosch
Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract.
Gut 2002;51(5):628-33.
2002: Catherine van Montfrans; Maikel Peppelenbosch; Anje A Te Velde; Sander J H van Deventer
Inflammatory signal transduction in Crohn's disease and novel therapeutic approaches.
Biochemical pharmacology 2002;64(5-6):789-95.
2002: Henri H Versteeg; Brit Sorensen; Sjoukje H Slofstra; Jan H M Van den Brande; Jord Stam; Paul M P van Bergen en Henegouwen; Dick J Richel; Lars C Petersen; Maikel Peppelenbosch
VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation.
The Journal of biological chemistry 2002;277(30):27065-72.
2002: Bernt van den Blink; A J van der Kleij; Henri H Versteeg; Maikel Peppelenbosch
Immunomodulatory effect of oxygen and pressure.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2002;132(1):193-7.
2002: Judith Branger; Bernt van den Blink; Sebastiaan Weijer; Jeffrey Madwed; Carina L Bos; Abhya Gupta; Chan-Loi Yong; Stephen H Polmar; Dariusz P Olszyna; C Erik Hack; Sander J H van Deventer; Maikel Peppelenbosch; Tom van der Poll
Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):4070-7.
2002: Tessa ten Hove; Bernt van den Blink; I Pronk; Paul Drillenburg; Maikel Peppelenbosch; Sander J H van Deventer
Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis.
Gut 2002;50(4):507-12.
2002: T ten Hove; Catherine van Montfrans; Maikel Peppelenbosch; Sander J H van Deventer
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease.
Gut 2002;50(2):206-11.
2002: Luisa Camoglio; Nicole P Juffermans; Maikel Peppelenbosch; Anje A Te Velde; Fibo J ten Kate; Sander J H van Deventer; Manfred Kopf
Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis.
European journal of immunology 2002;32(1):261-9.
2002: Daan W Hommes; Bernt van den Blink; Terry Plasse; Joep F W M Bartelsman; Cuiping Xu; Bret Macpherson; Guido Tytgat; Maikel Peppelenbosch; Sander J H van Deventer
Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease.
Gastroenterology 2002;122(1):7-14.
2002: Gijs R van den Brink; Daniëlle E M van den Boogaardt; Sander J H van Deventer; Maikel Peppelenbosch
Feed a cold, starve a fever?
Clinical and diagnostic laboratory immunology 2002;9(1):182-3.
2001: Henri H Versteeg; Maikel Peppelenbosch; C Arnold Spek
The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling?
Thrombosis and haemostasis 2001;86(6):1353-9.
2001: Bernt van den Blink; Judith Branger; Sebastiaan Weijer; S H Deventer; Tom van der Poll; Maikel Peppelenbosch
Human endotoxemia activates p38 MAP kinase and p42/44 MAP kinase, but not c-Jun N-terminal kinase.
Molecular medicine (Cambridge, Mass.) 2001;7(11):755-60.
2001: Maikel Peppelenbosch; Henri H Versteeg
Cell biology of tissue factor, an unusual member of the cytokine receptor family.
Trends in cardiovascular medicine 2001;11(8):335-9.
2001: Gijs R van den Brink; James C H Hardwick; G N J Tytgat; M A Brink; Fiebo J W Ten Kate; Sander J H van Deventer; Maikel Peppelenbosch
Sonic hedgehog regulates gastric gland morphogenesis in man and mouse.
Gastroenterology 2001;121(2):317-28.
2001: James C H Hardwick; Gijs R van den Brink; G Johan A Offerhaus; Sander J H van Deventer; Maikel Peppelenbosch
Leptin is a growth factor for colonic epithelial cells.
Gastroenterology 2001;121(1):79-90.
2001: Marcus Schultz; J Wijnholds; Maikel Peppelenbosch; Margriet J Vervoordeldonk; Peter Speelman; Sander J H van Deventer; P Borst; Tom van der Poll
Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):4059-64.
2001: James C H Hardwick; Gijs R van den Brink; G Johan A Offerhaus; Sander J H van Deventer; Maikel Peppelenbosch
NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps.
Oncogene 2001;20(7):819-27.
2001: Sander H Diks; Sander J H van Deventer; Maikel Peppelenbosch
Lipopolysaccharide recognition, internalisation, signalling and other cellular effects.
Journal of endotoxin research 2001;7(5):335-48.
2001: Bernt van den Blink; Nicole P Juffermans; Tessa ten Hove; Marcus Schultz; Sander J H van Deventer; Tom van der Poll; Maikel Peppelenbosch
p38 mitogen-activated protein kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):582-7.
2000: Henri H Versteeg; Evert H J Nijhuis; Gijs R van den Brink; M Evertzen; Gwenda Pynaert; Sander J H van Deventer; Paul J Coffer; Maikel Peppelenbosch
A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein.
The Biochemical journal 2000;350 Pt 3():717-22.
2000: Henri H Versteeg; I Hoedemaeker; Sander H Diks; Jord Stam; M Spaargaren; Paul M P van Bergen en Henegouwen; Sander J H van Deventer; Maikel Peppelenbosch
Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac.
The Journal of biological chemistry 2000;275(37):28750-6.
2000: Gijs R van den Brink; T O'Toole; James C H Hardwick; Daniëlle E M van den Boogaardt; Henri H Versteeg; Sander J H van Deventer; Maikel Peppelenbosch
Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase.
Molecular cell biology research communications : MCBRC 2000;4(3):144-50.
2000: Nicole P Juffermans; Pascale E P Dekkers; Maikel Peppelenbosch; Peter Speelman; Sander J H van Deventer; Tom van der Poll
Expression of the chemokine receptors CXCR1 and CXCR2 on granulocytes in human endotoxemia and tuberculosis: involvement of the p38 mitogen-activated protein kinase pathway.
The Journal of infectious diseases 2000;182(3):888-94.
2000: Maikel Peppelenbosch; M Desmedt; Gwenda Pynaert; Sander J H van Deventer; Johan Grooten
Macrophages present pinocytosed exogenous antigen via MHC class I whereas antigen ingested by receptor-mediated endocytosis is presented via MHC class II.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1984-91.
2000: G R van Den Brink; F J ten Kate; C Y Ponsioen; M M Rive; G N Tytgat; S J van Deventer; Maikel Peppelenbosch
Expression and activation of NF-kappa B in the antrum of the human stomach.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3353-9.
2000: Henri H Versteeg; M W Evertzen; Sander J H van Deventer; Maikel Peppelenbosch
The role of phosphatidylinositide-3-kinase in basal mitogen-activated protein kinase activity and cell survival.
FEBS letters 2000;465(1):69-73.
2000: Bernt van den Blink; H M Jansen; Maikel Peppelenbosch
Idiopathic pulmonary fibrosis: molecular mechanisms and possible therapeutic strategies.
Archivum immunologiae et therapiae experimentalis 2000;48(6):539-45.
1999: Gwenda Pynaert; Johan Grooten; Sander J H van Deventer; Maikel Peppelenbosch
Cysteinyl leukotrienes mediate histamine hypersensitivity ex vivo by increasing histamine receptor numbers.
Molecular medicine (Cambridge, Mass.) 1999;5(10):685-92.
1999: Gijs R van den Brink; S M Bloemers; Bernt van den Blink; Leon Tertoolen; Sander J H van Deventer; Maikel Peppelenbosch
Study of calcium signaling in non-excitable cells.
Microscopy research and technique 1999;46(6):418-33.
1999: Maikel Peppelenbosch; M Desmedt; Tessa ten Hove; Sander J H van Deventer; Johan Grooten
Lipopolysaccharide regulates macrophage fluid phase pinocytosis via CD14-dependent and CD14-independent pathways.
Blood 1999;93(11):4011-8.
1999: Henri H Versteeg; Paul M P van Bergen en Henegouwen; Sander J H van Deventer; Maikel Peppelenbosch
Cyclooxygenase-dependent signalling: molecular events and consequences.
FEBS letters 1999;445(1):1-5.
1999: AA van Puijenbroek; S Wissink; Paul T van der Saag; Maikel Peppelenbosch
Phospholipase A2 inhibitors and leukotriene synthesis inhibitors block TNF-induced NF-kappaB activation.
Cytokine 1999;11(2):104-10.
1999: Maikel Peppelenbosch; Elke Boone; G E Jones; S J van Deventer; Guy Haegeman; Walter Fiers; Johan Grooten; Anne J Ridley
Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNF.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):837-45.
1999: Anne J Ridley; William E Allen; Maikel Peppelenbosch; Gareth E Jones
Rho family proteins and cell migration.
Biochemical Society symposium 1999;65():111-23.
1998: S M Bloemers; S Verheule; Maikel Peppelenbosch; M J Smit; Leon Tertoolen; SW De Laat
Sensitization of the histamine H1 receptor by increased ligand affinity.
The Journal of biological chemistry 1998;273(4):2249-55.
1996: W G van Inzen; Maikel Peppelenbosch; M W van den Brand; Leon Tertoolen; SW De Laat
Neuronal differentiation of embryonic stem cells.
Biochimica et biophysica acta 1996;1312(1):21-6.
1996: Maikel Peppelenbosch; Leon Tertoolen; Alida M M de Vries-Smits; R G Qiu; L M'Rabet; Marc Symons; SW De Laat; Johannes L Bos
Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx.
The Journal of biological chemistry 1996;271(14):7883-6.
1996: W G van Inzen; Maikel Peppelenbosch; M W van den Brand; Leon Tertoolen; SW De Laat
The role of receptor protein tyrosine phosphatase alpha in neuronal differentiation of embryonic stem cells.
Brain research. Developmental brain research 1996;91(2):304-7.
1995: Paul J Coffer; Boudewijn M T Burgering; Maikel Peppelenbosch; Johannes L Bos; Wiebe Kruijer
UV activation of receptor tyrosine kinase activity.
Oncogene 1995;11(3):561-9.
1995: Maikel Peppelenbosch; R G Qiu; Alida M M de Vries-Smits; Leon Tertoolen; SW De Laat; F McCormick; Alan Hall; Marc Symons; Johannes L Bos
Rac mediates growth factor-induced arachidonic acid release.
Cell 1995;81(6):849-56.
1995: Maikel Peppelenbosch; Leon Tertoolen; SW De Laat; Danica Zivkovic
Ionic responses to epidermal growth factor in zebrafish cells.
Experimental cell research 1995;218(1):183-8.
1995: Maikel Peppelenbosch; Leon Tertoolen; Arjan van der Flier; SW De Laat
Evaluation of single-channel gating kinetics produced after amplitude-based separation of unitary currents.
Journal of neuroscience methods 1995;58(1-2):49-59.
1993: Jeroen den Hertog; C E Pals; Maikel Peppelenbosch; Leon Tertoolen; SW De Laat; Wiebe Kruijer
Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.
The EMBO journal 1993;12(10):3789-98.
1993: Maikel Peppelenbosch; Leon Tertoolen; WJ Hage; SW De Laat
Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products.
Cell 1993;74(3):565-75.
1992: Maikel Peppelenbosch; Leon Tertoolen; Jeroen den Hertog; SW De Laat
Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase-mediated leukotriene C4 production.
Cell 1992;69(2):295-303.
1991: Maikel Peppelenbosch; Leon Tertoolen; SW De Laat
Epidermal growth factor-activated calcium and potassium channels.
The Journal of biological chemistry 1991;266(30):19938-44.