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Pierre Nicolas

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Genes & Molecular Sequences

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Feten Abbassi; Thierry Foulon; Elodie Gazanion; Pierre Nicolas; Bruno Oury; Christophe Piesse; Zahid Raja; Denis Sereno; Ali Ladram
Antibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide.
Aurélia Delauné; Sarah Dubrac; Catherine Fitting; Aurélia Hiron; Aurélie Leduc; Ulrike Mäder; Minou Adib-Conquy; Charlène Blanchet; Jean-Marc Cavaillon; Pierre Nicolas; Olivier Poupel; Tarek Msadek
The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response.
Feten Abbassi; Olivier Lequin; Christophe Piesse; Nicole Goasdoué; Thierry Foulon; Pierre Nicolas; Ali Ladram
Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide.

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All Publications

2013: Feten Abbassi; Thierry Foulon; Elodie Gazanion; Pierre Nicolas; Bruno Oury; Christophe Piesse; Zahid Raja; Denis Sereno; Ali Ladram
Antibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide.
Biochimie 2013;95(2):388-99.
2012: Aurélia Delauné; Sarah Dubrac; Catherine Fitting; Aurélia Hiron; Aurélie Leduc; Ulrike Mäder; Minou Adib-Conquy; Charlène Blanchet; Jean-Marc Cavaillon; Pierre Nicolas; Olivier Poupel; Tarek Msadek
The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response.
Infection and immunity 2012;80(10):3438-53.
2010: Feten Abbassi; Olivier Lequin; Christophe Piesse; Nicole Goasdoué; Thierry Foulon; Pierre Nicolas; Ali Ladram
Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide.
The Journal of biological chemistry 2010;285(22):16880-92.
2009: Pierre Nicolas; Yvonne Rosenstein
Multifunctional host defense peptides.
The FEBS journal 2009;276(22):6464.
2009: Pierre Nicolas
Multifunctional host defense peptides: intracellular-targeting antimicrobial peptides.
The FEBS journal 2009;276(22):6483-96.
2009: Pierre Joanne; Mélanie Falord; Olivier Chesneau; Claire Lacombe; Sabine Castano; Bernard Desbat; Constance Auvynet; Pierre Nicolas; Tarek Msadek; Chahrazade El Amri
Comparative study of two plasticins: specificity, interfacial behavior, and bactericidal activity.
Biochemistry 2009;48(40):9372-83.
2009: Pierre Joanne; Cécile Galanth; Nicole Goasdoué; Pierre Nicolas; Sandrine Sagan; Solange Lavielle; Gérard Chassaing; Chahrazade El Amri; Isabel D Alves
Lipid reorganization induced by membrane-active peptides probed using differential scanning calorimetry.
Biochimica et biophysica acta 2009;1788(9):1772-81.
2009: Pierre Nicolas; Chahrazade El Amri
The dermaseptin superfamily: a gene-based combinatorial library of antimicrobial peptides.
Biochimica et biophysica acta 2009;1788(8):1537-50.
2009: P Joanne; Pierre Nicolas; Chahrazade El Amri
Antimicrobial peptides and viral fusion peptides: how different they are?
Protein and peptide letters 2009;16(7):743-50.
2008: Mohamed Amiche; Ali Ladram; Pierre Nicolas
A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae.
Peptides 2008;29(11):2074-82.
2008: Feten Abbassi; Cécile Galanth; Mohamed Amiche; Kazuko Saito; Christophe Piesse; Loussiné Zargarian; Khaled Hani; Pierre Nicolas; Olivier Lequin; Ali Ladram
Solution structure and model membrane interactions of temporins-SH, antimicrobial peptides from amphibian skin. A NMR spectroscopy and differential scanning calorimetry study.
Biochemistry 2008;47(40):10513-25.
2008: Feten Abbassi; Bruno Oury; Thierry Blasco; Denis Sereno; Gérard Bolbach; Pierre Nicolas; Khaled Hani; Mohamed Amiche; Ali Ladram
Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica.
Peptides 2008;29(9):1526-33.
2008: Constance Auvynet; Chahrazade El Amri; Claire Lacombe; Francine Bruston; Julie Bourdais; Pierre Nicolas; Yvonne Rosenstein
Structural requirements for antimicrobial versus chemoattractant activities for dermaseptin S9.
The FEBS journal 2008;275(16):4134-51.
2008: Ali Ladram; Isabelle Besné; Lionel Breton; Olivier de Lacharrière; Pierre Nicolas; Mohamed Amiche
Pharmacologic study of C-terminal fragments of frog skin calcitonin gene-related peptide.
Peptides 2008;29(7):1150-6.
2008: Chahrazade El Amri; Pierre Nicolas
Plasticins: membrane-damaging peptides with 'chameleon-like' properties.
Cellular and molecular life sciences : CMLS 2008;65(6):895-909.
2007: Chahrazade El Amri; Francine Bruston; P Joanne; Claire Lacombe; Pierre Nicolas
Intrinsic flexibility and structural adaptability of Plasticins membrane-damaging peptides as a strategy for functional versatility.
European biophysics journal : EBJ 2007;36(8):901-9.
2007: Francine Bruston; Claire Lacombe; K Zimmermann; Christophe Piesse; Pierre Nicolas; Chahrazade El Amri
Structural malleability of plasticins: preorganized conformations in solution and relevance for antimicrobial activity.
Biopolymers 2007;86(1):42-56.
2007: Viet-Laï Pham; Marie-Sandrine Cadel; Cécile Gouzy-Darmon; Chantal Hanquez; Margery C Beinfeld; Pierre Nicolas; Catherine Etchebest; Thierry Foulon
Aminopeptidase B, a glucagon-processing enzyme: site directed mutagenesis of the Zn2+-binding motif and molecular modelling.
BMC biochemistry 2007;8():21.
2006: Chahrazade El Amri; Claire Lacombe; Karel Zimmerman; Ali Ladram; Mohamed Amiche; Pierre Nicolas; Francine Bruston
The plasticins: membrane adsorption, lipid disorders, and biological activity.
Biochemistry 2006;45(48):14285-97.
2006: Olivier Lequin; Ali Ladram; Ludovic Chabbert; Francine Bruston; Odile Convert; Damien Vanhoye; Gérard Chassaing; Pierre Nicolas; Mohamed Amiche
Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini.
Biochemistry 2006;45(2):468-80.
2006: Constance Auvynet; Nabila Seddiki; Irene Dunia; Pierre Nicolas; Mohamed Amiche; Claire Lacombe
Post-translational amino acid racemization in the frog skin peptide deltorphin I in the secretion granules of cutaneous serous glands.
European journal of cell biology 2006;85(1):25-34.
2005: Ludovic Galas; Isabelle Bidaud; Marc Bulant; Bruce G Jenks; D T W M Ouwens; Sylvie Jégou; Ali Ladram; Eric W Roubos; Pierre Nicolas; Marie-Christine Tonon; Hubert Vaudry
In situ hybridization localization of TRH precursor and TRH receptor mRNAs in the brain and pituitary of Xenopus laevis.
Annals of the New York Academy of Sciences 2005;1040():95-105.
2004: Isabelle Bidaud; Ludovic Galas; Marc Bulant; Bruce G Jenks; D T W M Ouwens; Sylvie Jégou; Ali Ladram; Eric W Roubos; Marie-Christine Tonon; Pierre Nicolas; Hubert Vaudry
Distribution of the mRNAs encoding the thyrotropin-releasing hormone (TRH) precursor and three TRH receptors in the brain and pituitary of Xenopus laevis: effect of background color adaptation on TRH and TRH receptor gene expression.
The Journal of comparative neurology 2004;477(1):11-28.
2004: Damien Vanhoye; Francine Bruston; Shaharazade El Amri; Ali Ladram; Mohamed Amiche; Pierre Nicolas
Membrane association, electrostatic sequestration, and cytotoxicity of Gly-Leu-rich peptide orthologs with differing functions.
Biochemistry 2004;43(26):8391-409.
2003: Pierre Nicolas; Damien Vanhoye; Mohamed Amiche
Molecular strategies in biological evolution of antimicrobial peptides.
Peptides 2003;24(11):1669-80.
2003: Olivier Lequin; Francine Bruston; Odile Convert; Gérard Chassaing; Pierre Nicolas
Helical structure of dermaseptin B2 in a membrane-mimetic environment.
Biochemistry 2003;42(34):10311-23.
2003: Sylvie Noinville; Francine Bruston; Chahrazade El Amri; D Baron; Pierre Nicolas
Conformation, orientation, and adsorption kinetics of dermaseptin B2 onto synthetic supports at aqueous/solid interface.
Biophysical journal 2003;85(2):1196-206.
2003: Damien Vanhoye; Francine Bruston; Pierre Nicolas; Mohamed Amiche
Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.
European journal of biochemistry / FEBS 2003;270(9):2068-81.
2002: Jacques Riand; Pierre Nicolas; Daniel Baron
The mu-selective heptapeptide opioid dermorphin has two conformations around Phe3 psi with no head-to-tail interaction. A quantitative 2-D NMR and molecular modeling analysis.
Journal of biomolecular structure & dynamics 2002;20(3):359-73.
2002: Isabelle Bidaud; Philippe Lory; Pierre Nicolas; Marc Bulant; Ali Ladram
Characterization and functional expression of cDNAs encoding thyrotropin-releasing hormone receptor from Xenopus laevis.
European journal of biochemistry / FEBS 2002;269(18):4566-76.
2002: Thomas F Duda; Damien Vanhoye; Pierre Nicolas
Roles of diversifying selection and coordinated evolution in the evolution of amphibian antimicrobial peptides.
Molecular biology and evolution 2002;19(6):858-64.
2002: Ran Nir-Paz; Marie-Christine Prévost; Pierre Nicolas; Alain Blanchard; Henri Wróblewski
Susceptibilities of Mycoplasma fermentans and Mycoplasma hyorhinis to membrane-active peptides and enrofloxacin in human tissue cell cultures.
Antimicrobial agents and chemotherapy 2002;46(5):1218-25.
2001: L Dumery; F Bourdel; Y Soussan; A Fialkowsky; S Viale; Pierre Nicolas; Michèle Reboud-Ravaux
beta-Amyloid protein aggregation: its implication in the physiopathology of Alzheimer's disease.
Pathologie-biologie 2001;49(1):72-85.
2001: Irene Dunia; Michel Recouvreur; Pierre Nicolas; Nalin M Kumar; Hans Bloemendal; Ennio-Lucio Benedetti
Sodium dodecyl sulfate-freeze-fracture immunolabeling of gap junctions.
Methods in molecular biology (Clifton, N.J.) 2001;154():33-55.
2000: Claire Lacombe; C Cifuentes-Diaz; Irene Dunia; M Auber-Thomay; Pierre Nicolas; Mohamed Amiche
Peptide secretion in the cutaneous glands of South American tree frog Phyllomedusa bicolor: an ultrastructural study.
European journal of cell biology 2000;79(9):631-41.
2000: Ennio-Lucio Benedetti; Irene Dunia; Michel Recouvreur; Pierre Nicolas; Nalin M Kumar; Hans Bloemendal
Structural organization of gap junctions as revealed by freeze-fracture and SDS fracture-labeling.
European journal of cell biology 2000;79(8):575-82.
2000: Mohamed Amiche; AA Seon; H Wroblewski; Pierre Nicolas
Isolation of dermatoxin from frog skin, an antibacterial peptide encoded by a novel member of the dermaseptin genes family.
European journal of biochemistry / FEBS 2000;267(14):4583-92.
2000: AA Seon; TN Pierre; V Redeker; Claire Lacombe; A Delfour; Pierre Nicolas; Mohamed Amiche
Isolation, structure, synthesis, and activity of a new member of the calcitonin gene-related peptide family from frog skin and molecular cloning of its precursor.
The Journal of biological chemistry 2000;275(8):5934-40.
2000: TN Pierre; AA Seon; Mohamed Amiche; Pierre Nicolas
Phylloxin, a novel peptide antibiotic of the dermaseptin family of antimicrobial/opioid peptide precursors.
European journal of biochemistry / FEBS 2000;267(2):370-8.
1999: J Riand; D Baron; Pierre Nicolas; A Benajiba; Y Teng; M Naim
The delta-selective opioid peptide dermenkephalin and the mu-selective hybrid peptide dermenkephalin-[1-4]-dermophin-[5-7] display strikingly different conformations despite identical tetrapeptide N-termini. A quantitative 2-D NMR and molecular modeling analysis.
Journal of biomolecular structure & dynamics 1999;17(3):445-60.
1999: Hubert Vaudry; Nicolas Chartrel; Laurence Desrues; Ludovic Galas; Sakae Kikuyama; A Mor; Pierre Nicolas; Marie-Christine Tonon
The pituitary-skin connection in amphibians. Reciprocal regulation of melanotrope cells and dermal melanocytes.
Annals of the New York Academy of Sciences 1999;885():41-56.
1999: Mohamed Amiche; AA Seon; TN Pierre; Pierre Nicolas
The dermaseptin precursors: a protein family with a common preproregion and a variable C-terminal antimicrobial domain.
FEBS letters 1999;456(3):352-6.
1999: Jean-Jacques Montagne; Ali Ladram; Pierre Nicolas; Marc Bulant
Cloning of thyrotropin-releasing hormone precursor and receptor in rat thymus, adrenal gland, and testis.
Endocrinology 1999;140(3):1054-9.
1998: M Naim; Pierre Nicolas; A Benajiba; D Baron
Solution conformations of deltorphin-I obtained from combined use of quantitative 2D-NMR and energy calculations: a comparison with dermenkephalin.
The journal of peptide research : official journal of the American Peptide Society 1998;52(6):443-56.
1998: Irene Dunia; Michel Recouvreur; Pierre Nicolas; Nalin M Kumar; Hans Bloemendal; Ennio-Lucio Benedetti
Assembly of connexins and MP26 in lens fiber plasma membranes studied by SDS-fracture immunolabeling.
Journal of cell science 1998;111 ( Pt 15)():2109-20.
1998: B Ammar; Axel Périanin; A Mor; G Sarfati; Michèle Tissot; Pierre Nicolas; Jean-Paul Giroud; Monique Roch-Arveiller
Dermaseptin, a peptide antibiotic, stimulates microbicidal activities of polymorphonuclear leukocytes.
Biochemical and biophysical research communications 1998;247(3):870-5.
1998: S Charpentier; Mohamed Amiche; J Mester; V Vouille; J P Le Caer; Pierre Nicolas; A Delfour
Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics.
The Journal of biological chemistry 1998;273(24):14690-7.
1998: Y Fleury; V Vouille; L Beven; Mohamed Amiche; Henri Wróblewski; A Delfour; Pierre Nicolas
Synthesis, antimicrobial activity and gene structure of a novel member of the dermaseptin B family.
Biochimica et biophysica acta 1998;1396(2):228-36.
1998: Mohamed Amiche; A Delfour; Pierre Nicolas
Opioid peptides from frog skin.
EXS 1998;85():57-71.
1997: Jean-Jacques Montagne; Ali Ladram; D Grouselle; Pierre Nicolas; Marc Bulant
Thyrotropin-releasing hormone immunoreactivity in rat adrenal tissue is localized in mast cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(12):1623-7.
1997: V Vouille; Mohamed Amiche; Pierre Nicolas
Structure of genes for dermaseptins B, antimicrobial peptides from frog skin. Exon 1-encoded prepropeptide is conserved in genes for peptides of highly different structures and activities.
FEBS letters 1997;414(1):27-32.
1996: Y Fleury; M A Dayem; Jean-Jacques Montagne; E Chaboisseau; J P Le Caer; Pierre Nicolas; A Delfour
Covalent structure, synthesis, and structure-function studies of mesentericin Y 105(37), a defensive peptide from gram-positive bacteria Leuconostoc mesenteroides.
The Journal of biological chemistry 1996;271(24):14421-9.
1996: M A Dayem; Y Fleury; G Devilliers; E Chaboisseau; R Girard; Pierre Nicolas; A Delfour
The putative immunity protein of the gram-positive bacteria Leuconostoc mesenteroides is preferentially located in the cytoplasm compartment.
FEMS microbiology letters 1996;138(2-3):251-9.
1996: M Naim; Pierre Nicolas; D Baron
Folded conformations of the delta-selective opioid dermenkephalin with head-to-tail interactions. A simulated annealing study through NMR restraints.
International journal of peptide and protein research 1996;47(5):353-60.
1996: I Vouldoukis; Y Shai; Pierre Nicolas; A Mor
Broad spectrum antibiotic activity of the skin-PYY.
FEBS letters 1996;380(3):237-40.
1996: Jean-Jacques Montagne; Ali Ladram; D Grouselle; Pierre Nicolas; Marc Bulant
Identification and cellular localization of thyrotropin-releasing hormone-related peptides in rat testis.
Endocrinology 1996;137(1):185-91.
1995: Pierre Nicolas; A Mor
Peptides as weapons against microorganisms in the chemical defense system of vertebrates.
Annual review of microbiology 1995;49():277-304.
1995: K Abdoun; M Mesnier-Sabin; N Baudry-Partiaoglou; Pierre Nicolas; P Cohen
Separation of oviposition-stimulating peptides and myotropic factors from head extracts of Galleria mellonella L.: comparative effects of myotropic and non-myotropic factors on egg laying.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 1995;165(2):102-9.
1994: A Mor; K Hani; Pierre Nicolas
The vertebrate peptide antibiotics dermaseptins have overlapping structural features but target specific microorganisms.
The Journal of biological chemistry 1994;269(50):31635-41.
1994: A Mor; Nicolas Chartrel; H Vaudry; Pierre Nicolas
Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10295-9.
1994: J Strahilevitz; A Mor; Pierre Nicolas; Yechiel Shai
Spectrum of antimicrobial activity and assembly of dermaseptin-b and its precursor form in phospholipid membranes.
Biochemistry 1994;33(36):10951-60.
1994: Mohamed Amiche; Frédéric Ducancel; A Mor; Jean-Claude Boulain; A Menez; Pierre Nicolas
Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins.
The Journal of biological chemistry 1994;269(27):17847-52.
1994: A Mor; Mohamed Amiche; Pierre Nicolas
Structure, synthesis, and activity of dermaseptin b, a novel vertebrate defensive peptide from frog skin: relationship with adenoregulin.
Biochemistry 1994;33(21):6642-50.
1994: Ali Ladram; Marc Bulant; Jean-Jacques Montagne; Pierre Nicolas
Distribution of TRH-potentiating peptide (Ps4) and its receptors in rat brain and peripheral tissues.
Biochemical and biophysical research communications 1994;200(2):958-65.
1994: Pierre Nicolas; A Delfour
[Peptides of chemical immunity in vertebrates].
Pathologie-biologie 1994;42(4):287-91.
1994: A Mor; Pierre Nicolas
The NH2-terminal alpha-helical domain 1-18 of dermaseptin is responsible for antimicrobial activity.
The Journal of biological chemistry 1994;269(3):1934-9.
1994: A Mor; Pierre Nicolas
Isolation and structure of novel defensive peptides from frog skin.
European journal of biochemistry / FEBS 1994;219(1-2):145-54.
1994: S Charpentier; S Sagan; M Naim; A Delfour; Pierre Nicolas
Mechanism of delta-opioid receptor selection by the address domain of dermenkephalin.
European journal of pharmacology 1994;266(2):175-80.
1994: Ali Ladram; Jean-Jacques Montagne; Marc Bulant; Pierre Nicolas
Analysis of structural requirements for TRH-potentiating peptide receptor binding by analogue design.
Peptides 1994;15(3):429-33.
1994: Ali Ladram; Marc Bulant; A Delfour; Jean-Jacques Montagne; H Vaudry; Pierre Nicolas
Modulation of the biological activity of thyrotropin-releasing hormone by alternate processing of pro-TRH.
Biochimie 1994;76(3-4):320-8.
1993: M Naim; S Charpentier; Pierre Nicolas; D Baron
Quantitative two-dimensional NMR study of dermenkephalin, a highly potent and selective delta-opioid peptide.
Biopolymers 1993;33(12):1889-900.
1993: D Duchesne; M Naim; Pierre Nicolas; D Baron
Folding trends in a flexible peptide: two-dimensional NMR study of deltorphin-I, a delta selective opioid heptapeptide.
Biochemical and biophysical research communications 1993;195(2):630-6.
1993: Mohamed Amiche; Frédéric Ducancel; Evelyne Lajeunesse; Jean-Claude Boulain; A Ménez; Pierre Nicolas
Molecular cloning of a cDNA encoding the precursor of adenoregulin from frog skin. Relationships with the vertebrate defensive peptides, dermaseptins.
Biochemical and biophysical research communications 1993;191(3):983-90.
1992: Ali Ladram; Marc Bulant; Pierre Nicolas
Characterization of receptors for thyrotropin-releasing hormone-potentiating peptide on rat anterior pituitary membranes.
The Journal of biological chemistry 1992;267(36):25697-702.
1992: Marc Bulant; Ali Ladram; Jean-Jacques Montagne; A Delfour; Pierre Nicolas
Isolation and amino acid sequence of the TRH-potentiating peptide from bovine hypothalamus.
Biochemical and biophysical research communications 1992;189(2):1110-8.
1992: Y Pouny; D Rapaport; A Mor; Pierre Nicolas; Yechiel Shai
Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes.
Biochemistry 1992;31(49):12416-23.
1992: C Hernandez; A Mor; Fracehuli Dagger; Pierre Nicolas; A Hernandez; E L Benedetti; Irene Dunia
Functional and structural damage in Leishmania mexicana exposed to the cationic peptide dermaseptin.
European journal of cell biology 1992;59(2):414-24.
1992: A Mor; Mohamed Amiche; Pierre Nicolas
Enter a new post-translational modification: D-amino acids in gene-encoded peptides.
Trends in biochemical sciences 1992;17(12):481-5.
1992: S Sagan; S Charpentier; A Delfour; Mohamed Amiche; Pierre Nicolas
The aspartic acid in deltorphin I and dermenkephalin promotes targeting to delta-opioid receptor independently of receptor binding.
Biochemical and biophysical research communications 1992;187(3):1203-10.
1992: J C Ebiou; M Bulant; Pierre Nicolas; S Aratan-Spire
Pattern of thyrotropin-releasing hormone secretion from the adult and neonatal rat pancreas: comparison with insulin secretion.
Endocrinology 1992;130(3):1371-9.
1991: S Sagan; Alistair D Corbett; Mohamed Amiche; A Delfour; Pierre Nicolas; H W Kosterlitz
Opioid activity of dermenkephalin analogues in the guinea-pig myenteric plexus and the hamster vas deferens.
British journal of pharmacology 1991;104(2):428-32.
1991: S Charpentier; S Sagan; A Delfour; Pierre Nicolas
Dermenkephalin and deltorphin I reveal similarities within ligand-binding domains of mu- and delta-opioid receptors and an additional address subsite on the delta-receptor.
Biochemical and biophysical research communications 1991;179(3):1161-8.
1991: A Mor; V H Nguyen; A Delfour; D Migliore-Samour; Pierre Nicolas
Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin.
Biochemistry 1991;30(36):8824-30.
1991: A Mor; A Delfour; Pierre Nicolas
Identification of a D-alanine-containing polypeptide precursor for the peptide opioid, dermorphin.
The Journal of biological chemistry 1991;266(10):6264-70.
1991: N Liao; M Bulant; Pierre Nicolas; Hubert Vaudry; Georges Pelletier
Anatomical interactions of proopiomelanocortin (POMC)-related peptides, neuropeptide Y (NPY) and dopamine beta-hydroxylase (D beta H) fibers and thyrotropin-releasing hormone (TRH) neurons in the paraventricular nucleus of rat hypothalamus.
Neuropeptides 1991;18(2):63-7.
1990: Marc Bulant; J C Beauvillain; A Delfour; H Vaudry; Pierre Nicolas
Processing of thyrotropin-releasing hormone (TRH) prohormone in the rat olfactory bulb generates novel TRH-related peptides.
Endocrinology 1990;127(4):1978-85.
1990: A Mor; Philippe Pradelles; A Delfour; Jean-Jacques Montagne; F L Quintero; Marie Conrath; Pierre Nicolas
Evidence for Pro-dermorphin processing products in rat tissues.
Biochemical and biophysical research communications 1990;170(1):30-8.
1990: M Bulant; J P Roussel; H Astier; Pierre Nicolas; Hubert Vaudry
Processing of thyrotropin-releasing hormone prohormone (pro-TRH) generates a biologically active peptide, prepro-TRH-(160-169), which regulates TRH-induced thyrotropin secretion.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4439-43.
1990: Mohamed Amiche; S Sagan; A Mor; D Pelaprat; W Rostene; A Delfour; Pierre Nicolas
Characterisation and visualisation of [3H]dermorphin binding to mu opioid receptors in the rat brain. Combined high selectivity and affinity in a natural peptide agonist for the morphine (mu) receptor.
European journal of biochemistry / FEBS 1990;189(3):625-35.
1990: N Liao; M Bulant; Pierre Nicolas; Hubert Vaudry; Georges Pelletier
Immunoelectron microscopic localization of thyrotropin-releasing hormone (TRH) precursor in the rat raphe nuclei.
Peptides 1990;11(2):397-400.
1990: M C Tonon; L Désy; Pierre Nicolas; H Vaudry; G Pelletier
Immunocytochemical localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in the rat brain.
Neuropeptides 1990;15(1):17-24.
1989: A Robichon; Pierre Nicolas
Evidence for the synthesis of pro-CRF (corticotropin-releasing factor) in cultured fetal pancreatic islets of rats.
Experimental cell research 1989;185(1):283-91.
1989: S Sagan; Mohamed Amiche; A Delfour; A Mor; A Camus; Pierre Nicolas
Molecular determinants of receptor affinity and selectivity of the natural delta-opioid agonist, dermenkephalin.
The Journal of biological chemistry 1989;264(29):17100-6.
1989: A Mor; A Delfour; S Sagan; Mohamed Amiche; Philippe Pradelles; J Rossier; Pierre Nicolas
Isolation of dermenkephalin from amphibian skin, a high-affinity delta-selective opioid heptapeptide containing a D-amino acid residue.
FEBS letters 1989;255(2):269-74.
1989: S Sagan; Mohamed Amiche; A Delfour; A Camus; A Mor; Pierre Nicolas
Differential contribution of C-terminal regions of dermorphin and dermenkephalin to opioid-sites selection and binding potency.
Biochemical and biophysical research communications 1989;163(2):726-32.
1989: Leduque Patrick; M Bulant; P M Dubois; Pierre Nicolas; H Vaudry
Processing of thyrotropin-releasing hormone prohormone (pro-TRH) in the adult rat pancreas: identification and localization of pro-TRH-related peptides in beta-cells of pancreatic islets.
Endocrinology 1989;125(3):1492-7.
1989: N Liao; M Bulant; Pierre Nicolas; Hubert Vaudry; Georges Pelletier
Thyroid hormone regulation of neurons staining for a pro-TRH-derived cryptic peptide sequence in the rat hypothalamic paraventricular nucleus.
Neuroendocrinology 1989;50(2):217-21.
1989: Mohamed Amiche; S Sagan; A Mor; A Delfour; Pierre Nicolas
Dermenkephalin (Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2): a potent and fully specific agonist for the delta opioid receptor.
Molecular pharmacology 1989;35(6):774-9.
1989: Anne Dutour; M Bulant; P Giraud; Pierre Nicolas; H Vaudry; Charles Oliver
Pro-TRH-connecting peptides in the rat pancreas during ontogenesis.
Peptides 1989;10(3):523-7.
1989: A Mor; A Delfour; Mohamed Amiche; S Sagan; Pierre Nicolas; J Grassi; Philippe Pradelles
Dermorphin and related peptides in rat tissues.
Neuropeptides 1989;13(1):51-7.
1989: Marie-Christine Tonon; S Adjeroud; M Lamacz; Estelle Louiset; J M Danger; Laurence Desrues; L Cazin; Pierre Nicolas; Hubert Vaudry
Central-type benzodiazepines and the octadecaneuropeptide modulate the effects of GABA on the release of alpha-melanocyte-stimulating hormone from frog neurointermediate lobe in vitro.
Neuroscience 1989;31(2):485-93.
1988: Mohamed Amiche; S Sagan; A Mor; A Delfour; Pierre Nicolas
Characterization of the receptor binding profile of (3H)-dermorphin in the rat brain.
International journal of peptide and protein research 1988;32(6):506-11.
1988: Marc Bulant; A Delfour; H Vaudry; Pierre Nicolas
Processing of thyrotropin-releasing hormone prohormone (pro-TRH) generates pro-TRH-connecting peptides. Identification and characterization of prepro-TRH-(160-169) and prepro-TRH-(178-199) in the rat nervous system.
The Journal of biological chemistry 1988;263(32):17189-96.
1988: Mohamed Amiche; A Delfour; Pierre Nicolas
Structural requirements for dermorphin opioid receptor binding.
International journal of peptide and protein research 1988;32(1):28-34.
1988: N Liao; M Bulant; Pierre Nicolas; Hubert Vaudry; Georges Pelletier
Immunocytochemical distribution of neurons containing a peptide derived from thyrotropin-releasing hormone precursor in the rat brain.
Neuroscience letters 1988;85(1):24-8.
1988: Pierre Nicolas
Secondary processing of neurohormones: intracellular proteolytic cleavage of beta-endorphin generates new active neuropeptides.
Biochimie 1988;70(2):177-82.
1987: Mohamed Amiche; A Delfour; J L Morgat; J Roy; J Houvet; Pierre Nicolas
Specific opioid binding sites for dermorphin in rat brain. A radioreceptor assay using the tritiated hormone as primary ligand.
Biochemical and biophysical research communications 1987;148(3):1432-9.
1986: M Rholam; Pierre Nicolas; P Cohen
Precursors for peptide hormones share common secondary structures forming features at the proteolytic processing sites.
FEBS letters 1986;207(1):1-6.
1986: C Clamagirand; M Camier; H Boussetta; C Fahy; Alain Morel; Pierre Nicolas; Paul Cohen
An endopeptidase associated with bovine neurohypophysis secretory granules cleaves pro-ocytocin/neurophysin peptide at paired basic residues.
Biochemical and biophysical research communications 1986;134(3):1190-6.
1985: M Rholam; Pierre Nicolas; P Cohen
Salt-dependent structural changes of neurohormones: lithium ions induce conformational rearrangements of ocytocin to a vasopressin-like structure.
Biochemistry 1985;24(13):3345-9.
1985: Pierre Nicolas; C H Li
Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(10):3178-81.
1985: M Rholam; Pierre Nicolas
Conformational flexibility of neurophysin as investigated by local motions of fluorophores. Relationships with neurohypophyseal hormone binding.
Biochemistry 1985;24(8):1928-33.
1985: Pierre Nicolas; C H Li
Inhibition of analgesia by C-terminal deletion analogs of human beta-endorphin.
Biochemical and biophysical research communications 1985;127(2):649-55.
1985: Paul Cohen; Alain Morel; P Gluschankof; S Gomez; Pierre Nicolas
Proteolytic events in the post-translational processing of somatostatin precursors from rat brain cortex and anglerfish pancreatic islets.
Advances in experimental medicine and biology 1985;188():109-21.
1984: P Gluschankof; Alain Morel; S Gomez; Pierre Nicolas; C Fahy; Paul Cohen
Enzymes processing somatostatin precursors: an Arg-Lys esteropeptidase from the rat brain cortex converting somatostatin-28 into somatostatin-14.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(21):6662-6.
1984: Pierre Nicolas; R G Hammonds; C H Li
beta-Endorphin-induced analgesia is inhibited by synthetic analogs of beta-endorphin.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(10):3074-7.
1984: R G Hammonds; Pierre Nicolas; C H Li
beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(5):1389-90.
1983: A Morel; Pierre Nicolas; P Cohen
Evidence for a predominant form of Mr = 15,000 prosomatostatin in the mouse hypothalamus. Relationship with somatostatin-14 and -28.
The Journal of biological chemistry 1983;258(13):8273-6.
1983: S Gomez; A Morel; Pierre Nicolas; P Cohen
Regional distribution of the Mr 15,000 somatostatin precursor, somatostatin-28 and somatostatin-14 in the rat brain suggests a differential intracellular processing of the high molecular weight species.
Biochemical and biophysical research communications 1983;112(1):297-305.
1983: D Yamashiro; Pierre Nicolas; C H Li
Synthesis and properties of dermorphin and an analog of beta-endorphin containing the dermorphin sequence.
International journal of peptide and protein research 1983;21(3):219-22.
1982: R G Hammonds; Pierre Nicolas; C H Li
Characterization of beta-endorphin binding protein (receptor) from rat brain membranes.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(21):6494-6.
1982: J Blake; C H Li; Pierre Nicolas
Beta-endorphin: synthesis and properties of analogs with replacement of lysine residues by arginine.
International journal of peptide and protein research 1982;20(4):308-11.
1982: M Rholam; Pierre Nicolas; P Cohen
Binding of neurohypophyseal peptides to neurophysin dimer promotes formation of compact and spherical complexes.
Biochemistry 1982;21(20):4968-73.
1982: R Garzia; D Yamashiro; C H Li; Pierre Nicolas
beta-Endorphin: synthesis and properties of human beta-endorphin-(1--28) and its analogs.
International journal of peptide and protein research 1982;20(3):194-8.
1982: Pierre Nicolas; R G Hammonds; S Gomez; C H Li
Beta-endorphin: thermodynamics of the binding reaction with rat brain membranes.
Archives of biochemistry and biophysics 1982;217(1):80-6.
1982: D Yamashiro; Pierre Nicolas; C H Li
beta-Endorphin: synthesis and properties of analogs modified in positions 8 and 31.
International journal of peptide and protein research 1982;20(1):43-6.
1982: R G Hammonds; Pierre Nicolas; C H Li
beta-Endorphin: analgesic and receptor binding activity of non-mammalian homologs.
International journal of peptide and protein research 1982;19(5):556-61.
1982: D Yamashiro; C H Li; Pierre Nicolas; R G Hammonds
Beta-Endorphin. Synthesis and properties of double-headed and related analogs.
International journal of peptide and protein research 1982;19(4):348-53.
1982: Pierre Nicolas; R G Hammonds; C H Li
Beta-endorphin: opiate receptor binding activities of six naturally occurring beta-endorphin homologs studied by using tritiated human hormone and naloxone as primary ligands--effects of sodium ion.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(7):2191-3.
1982: C H Li; D Yamashiro; Pierre Nicolas
Beta-endorphin: replacement of tyrosine in position 27 by tryptophan increases analgesic potency--preparation and properties of the 2-nitrophenylsulfenyl derivative.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(4):1042-4.
1981: Pierre Nicolas; T A Bewley; László Gráf; C H Li
beta-Endorphin: demonstration of a tertiary structure in aqueous solution.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(12):7290-3.
1981: M Lauber; Pierre Nicolas; H Boussetta; C Fahy; P Béguin; M Camier; H Vaudry; Paul Cohen
The Mr 80,000 common forms of neurophysin and vasopressin from bovine neurohypophysis have corticotropin- and beta-endorphin-like sequences and liberate by proteolysis biologically active corticotropin.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(10):6086-90.
1981: M Rholam; Pierre Nicolas
Side-by-side dimerization of neurophysin: sedimentation velocity, viscometry, and fluorescence polarization studies.
Biochemistry 1981;20(20):5837-43.
1981: P Béguin; Pierre Nicolas; H Boussetta; C Fahy; Paul Cohen
Characterization of the 80,000 molecular weight form of neurophysin isolated from bovine neurohypophysis.
The Journal of biological chemistry 1981;256(17):9289-94.
1981: C H Li; D Yamashiro; R G Hammonds; Pierre Nicolas; L F Tseng
beta-Endorphin: replacement of glutamic acid in position 8 by glutamine increases analgesic potency and opiate receptor-binding activity.
Biochemical and biophysical research communications 1981;101(1):118-23.
1980: M Camier; M Lauber; Pierre Nicolas; M J Masse; H Boussetta; P Beguin; Paul Cohen
[Biosynthesis of some hypothalamic neuropeptides. Identification of precursor forms (author's transl)].
Annales d'endocrinologie 1980;41(6):466-77.
1980: Pierre Nicolas; G Batelier; M Rholam; P Cohen
Bovine neurophysin dimerization and neurohypophyseal hormone binding.
Biochemistry 1980;19(15):3565-73.
1980: Pierre Nicolas; M Camier; M Lauber; M J Masse; J Möhring; Paul Cohen
Immunological identification of high molecular weight forms common to bovine neurophysin and vasopressin.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(5):2587-91.
1979: P Cohen; Pierre Nicolas; M Camier
Biochemical aspects of neurosecretion: neurophysin--neurohypophyseal hormone complexes.
Current topics in cellular regulation 1979;15():263-318.
1978: Pierre Nicolas; J Wolff; M Camier; C Di Bello; P Cohen
Importance of neurophysin dimer and of tyrosine-49 in the binding of neurohypophyseal peptides.
The Journal of biological chemistry 1978;253(8):2633-9.
1978: Pierre Nicolas; P Dessen; M Camier; P Cohen
Cooperative binding of ocytocin to bovine neurophysin. A comparison of two theoretical models.
FEBS letters 1978;86(2):188-92.
1977: O Convert; J H Griffin; C Di Bello; Pierre Nicolas; P Cohen
Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for the analysis of peptide hormone interactions with bovine neurophysin I using 13C nuclear magnetic resonance spectroscopy.
Biochemistry 1977;16(23):5061-5.
1977: J H Griffin; C DiBello; R Alazard; Pierre Nicolas; P Cohen
Carbon-13 nuclear magnetic resonance studies of the binding of selectively 13C-enriched oxytocins to the neurophypophyseal protein, bovine neurophysin II.
Biochemistry 1977;16(19):4194-8.
1977: D Bonne; Pierre Nicolas; M Lauber; M Camier; A Tixier-vidal; P Cohen
Evidence for an adenylate-cyclase activity in neurosecretory granule membranes from bovine neurohypophysis.
European journal of biochemistry / FEBS 1977;78(2):337-42.
1976: M Camier; Pierre Nicolas; P Cohen
A comparative study of the lipid content and lecithin-binding capacity of bovine neurophysins.
FEBS letters 1976;67(2):137-42.
1976: Pierre Nicolas; M Camier; P Dessen; P Cohen
Interactions of oxytocin and vasopressin with bovine neurophysins I and II. Effects of hormone binding on the protein quaternary structure: a simple model.
The Journal of biological chemistry 1976;251(13):3965-71.