Kapil Bhalla

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Ustun Celalettin; DeRemer David L; Jillella Anand P; Bhalla Kapil N
Investigational drugs targeting FLT3 for leukemia.
Dickinson Michael; Ritchie David; DeAngelo Daniel J; Spencer Andrew; Ottmann Oliver G; Fischer Thomas; Bhalla Kapil N; Liu Angela; Parker Katie; Scott Jeffrey W; Bishton Mark; Prince H Miles
Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma.
Robertson Keith D; Bhalla Kapil N
Missteps in "tango" for epigenome targeting.

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All Publications

2009: Ustun Celalettin; DeRemer David L; Jillella Anand P; Bhalla Kapil N
Investigational drugs targeting FLT3 for leukemia.
Expert opinion on investigational drugs 2009;18(10):1445-56.
2009: Dickinson Michael; Ritchie David; DeAngelo Daniel J; Spencer Andrew; Ottmann Oliver G; Fischer Thomas; Bhalla Kapil N; Liu Angela; Parker Katie; Scott Jeffrey W; Bishton Mark; Prince H Miles
Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma.
British journal of haematology 2009;147(1):97-101.
2009: Robertson Keith D; Bhalla Kapil N
Missteps in "tango" for epigenome targeting.
Blood 2009;114(13):2569-70.
2009: Fiskus Warren; Wang Yongchao; Sreekumar Arun; Buckley Kathleen M; Shi Huidong; Jillella Anand; Ustun Celalettin; Rao Rekha; Fernandez Pravina; Chen Jianguang; Balusu Ramesh; Koul Sanjay; Atadja Peter; Marquez Victor E; Bhalla Kapil N
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.
Blood 2009;114(13):2733-43.
2009: Rao Rekha; Lee Pearl; Fiskus Warren; Yang Yonghua; Joshi Rajeshree; Wang Yongchao; Buckley Kate; Balusu Ramesh; Chen Jianguang; Koul Sanjay; Joshi Atul; Upadhyay Sunil; Tao Jianguo; Sotomayor Eduardo; Bhalla Kapil N
Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells.
Cancer biology & therapy 2009;8(13):1273-80.
2009: Mahalingam D; Swords R; Carew J S; Nawrocki S T; Bhalla K; Giles F J
Targeting HSP90 for cancer therapy.
British journal of cancer 2009;100(10):1523-9.
2009: Buckley Kathleen; Fiskus Warren; Bhalla Kapil
Activation of mTOR: A new mechanism "PIMed".
Cancer biology & therapy 2009;8(9):854-5.
2009: Fiskus Warren; Buckley Kate; Rao Rekha; Mandawat Aditya; Yang Yonghua; Joshi Rajeshree; Wang Yongchao; Balusu Ramesh; Chen Jianguang; Koul Sanjay; Joshi Atul; Upadhyay Sunil; Atadja Peter; Bhalla Kapil N
Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells.
Cancer biology & therapy 2009;8(10):939-50.
2009: Ustun Celalettin; Corless Christopher L; Savage Natasha; Fiskus Warren; Manaloor Elizabeth; Heinrich Michael C; Lewis Grant; Ramalingam Preetha; Kepten Ilana; Jillella Anand; Bhalla Kapil
Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V.
Leukemia research 2009;33(5):735-41.
2009: Yamaguchi Hirohito; Woods Nicholas T; Piluso Landon G; Lee Heng-Huan; Chen Jiandong; Bhalla Kapil N; Monteiro Alvaro; Liu Xuan; Hung Mien-Chie; Wang Hong-Gang
p53 acetylation is crucial for its transcription-independent proapoptotic functions.
The Journal of biological chemistry 2009;284(17):11171-83.
2009: Chen Jianguang; Fiskus Warren; Eaton Kelly; Fernandez Pravina; Wang Yongchao; Rao Rekha; Lee Pearl; Joshi Rajeshree; Yang Yonghua; Kolhe Ravindra; Balusu Ramesh; Chappa Prasanthi; Natarajan Kavita; Jillella Anand; Atadja Peter; Bhalla Kapil N
Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77-based mechanism.
Blood 2009;113(17):4038-48.
2009: Kimmick G G; Cirrincione C; Duggan D B; Bhalla K; Robert N; Berry D; Norton L; Lemke S; Henderson I C; Hudis C; Winer E;
Fifteen-year median follow-up results after neoadjuvant doxorubicin, followed by mastectomy, followed by adjuvant cyclophosphamide, methotrexate, and fluorouracil (CMF) followed by radiation for stage III breast cancer: a phase II trial (CALGB 8944).
Breast cancer research and treatment 2009;113(3):479-90.
2009: Villagra Alejandro; Cheng Fengdong; Wang Hong-Wei; Suarez Ildelfonso; Glozak Michelle; Maurin Michelle; Nguyen Danny; Wright Kenneth L; Atadja Peter W; Bhalla Kapil; Pinilla-Ibarz Javier; Seto Edward; Sotomayor Eduardo M
The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance.
Nature immunology 2009;10(1):92-100.
2008: Fiskus Warren; Wang Yongchao; Joshi Rajeshree; Rao Rekha; Yang Yonghua; Chen Jianguang; Kolhe Ravindra; Balusu Ramesh; Eaton Kelly; Lee Pearl; Ustun Celalettin; Jillella Anand; Buser Carolyn A; Peiper Stephen; Bhalla Kapil
Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(19):6106-15.
2008: Fiskus Warren; Rao Rekha; Fernandez Pravina; Herger Bryan; Yang Yonghua; Chen Jianguang; Kolhe Ravindra; Mandawat Aditya; Wang Yongchao; Joshi Rajeshree; Eaton Kelly; Lee Pearl; Atadja Peter; Peiper Stephen; Bhalla Kapil
Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.
Blood 2008;112(7):2896-905.
2008: Rao Rekha; Fiskus Warren; Yang Yonghua; Lee Pearl; Joshi Rajeshree; Fernandez Pravina; Mandawat Aditya; Atadja Peter; Bradner James E; Bhalla Kapil
HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.
Blood 2008;112(5):1886-93.
2008: Yang Yonghua; Rao Rehka; Shen Jie; Tang Yun; Fiskus Warren; Nechtman John; Atadja Peter; Bhalla Kapil
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion.
Cancer research 2008;68(12):4833-42.
2008: Jilani Iman; Kantarjian Hagop; Faraji Homan; Gorre Mercedes; Cortes Jorge; Ottmann Oliver; Bhalla Kapil; O'Brien Susan; Giles Francis; Albitar Maher
An immunological method for the detection of BCR-ABL fusion protein and monitoring its activation.
Leukemia research 2008;32(6):936-43.
2008: Jilani Iman; Kantarjian Hagop; Gorre Mercedes; Cortes Jorge; Ottmann Oliver; Bhalla Kapil; Giles Francis J; Albitar Maher
Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy.
Leukemia research 2008;32(4):643-9.
2008: Chawla R; Bhalla P; Bhalla K; Singh M Meghachandra; Garg S
Community-based study on seroprevalence of herpes simplex virus type 2 infection in New Delhi.
Indian journal of medical microbiology 2008;26(1):34-9.
2007: Woods Nicholas T; Yamaguchi Hirohito; Lee Francis Y; Bhalla Kapil N; Wang Hong-Gang
Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis.
Cancer research 2007;67(22):10744-52.
2007: Yang Yonghua; Fu Wei; Chen Jiandong; Olashaw Nancy; Zhang Xiaohong; Nicosia Santo V; Bhalla Kapil; Bai Wenlong
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress.
Nature cell biology 2007;9(11):1253-62.
2007: Kantarjian Hagop M; Giles Francis; Gattermann Norbert; Bhalla Kapil; Alimena Giuliana; Palandri Francesca; Ossenkoppele Gert J; Nicolini Franck-Emmanuel; O'Brien Stephen G; Litzow Mark; Bhatia Ravi; Cervantes Francisco; Haque Ariful; Shou Yaping; Resta Debra J; Weitzman Aaron; Hochhaus Andreas; le Coutre Philipp
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance.
Blood 2007;110(10):3540-6.
2007: Edwards Arthur; Li Jiannong; Atadja Peter; Bhalla Kapil; Haura Eric B
Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor-dependent human lung cancer cells.
Molecular cancer therapeutics 2007;6(9):2515-24.
2007: Fiskus Warren; Ren Yuan; Mohapatra Alex; Bali Purva; Mandawat Aditya; Rao Rekha; Herger Bryan; Yang Yonghua; Atadja Peter; Wu Jie; Bhalla Kapil
Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(16):4882-90.
2007: Khaki P; Bhalla P; Sharma P; Chawla R; Bhalla K
Epidemilogical analysis of Neisseria gonorrhoeae isolates by antimicrobial susceptibility testing, auxotyping and serotyping.
Indian journal of medical microbiology 2007;25(3):225-9.
2007: O'Brien Susan; Berman Ellin; Bhalla Kapil; Copelan Edward A; Devetten Marcel P; Emanuel Peter D; Erba Harry P; Greenberg Peter L; Moore Joseph O; Przepiorka Donna; Radich Jerald P; Schilder Russell J; Shami Paul; Smith B Douglas; Snyder David S; Soiffer Robert J; Tallman Martin S; Talpaz Moshe; Wetzler Meir;
Chronic myelogenous leukemia.
Journal of the National Comprehensive Cancer Network : JNCCN 2007;5(5):474-96.
2007: Nam Sangkil; Williams Ann; Vultur Adina; List Alan; Bhalla Kapil; Smith David; Lee Francis Y; Jove Richard
Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells.
Molecular cancer therapeutics 2007;6(4):1400-5.
2007: Bhalla Preena; Baveja U K; Chawla R; Saini S; Khaki P; Bhalla K; Mahajan S; Reddy B S N
Simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis by PCR in genitourinary specimens from men and women attending an STD clinic.
The Journal of communicable diseases 2007;39(1):1-6.
2006: Fiskus Warren; Pranpat Michael; Balasis Maria; Herger Bryan; Rao Rekha; Chinnaiyan Arul; Atadja Peter; Bhalla Kapil
Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells.
Molecular cancer therapeutics 2006;5(12):3096-104.
2006: Ma W; Kantarjian H; Jilani I; Gorre M; Bhalla K; Ottmann O; Giles F; Albitar M
Heterogeneity in detecting Abl kinase mutations and better sensitivity using circulating plasma RNA.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(11):1989-91.
2006: Fiskus Warren; Pranpat Michael; Balasis Maria; Bali Purva; Estrella Veronica; Kumaraswamy Sandhya; Rao Rekha; Rocha Kathy; Herger Bryan; Lee Francis; Richon Victoria; Bhalla Kapil
Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5869-78.
2006: Demidenko Z N; Vivo C; Halicka H D; Li C J; Bhalla K; Broude E V; Blagosklonny M V
Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection.
Cell death and differentiation 2006;13(9):1434-41.
2006: Giles Francis; Fischer Thomas; Cortes Jorge; Garcia-Manero Guillermo; Beck Joachim; Ravandi Farhad; Masson Eric; Rae Patricia; Laird Glen; Sharma Sunil; Kantarjian Hagop; Dugan Margaret; Albitar Maher; Bhalla Kapil
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4628-35.
2006: Lau Quek Choon; Raja Erna; Salto-Tellez Manuel; Liu Qiang; Ito Kosei; Inoue Masafumi; Putti Thomas Choudary; Loh Marie; Ko Tun Kiat; Huang Canhua; Bhalla Kapil N; Zhu Tao; Ito Yoshiaki; Sukumar Saraswati
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer.
Cancer research 2006;66(13):6512-20.
2006: Fiskus Warren; Pranpat Michael; Bali Purva; Balasis Maria; Kumaraswamy Sandhya; Boyapalle Sandhya; Rocha Kathy; Wu Jie; Giles Francis; Manley Paul W; Atadja Peter; Bhalla Kapil
Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells.
Blood 2006;108(2):645-52.
2006: Kantarjian Hagop; Giles Francis; Wunderle Lydia; Bhalla Kapil; O'Brien Susan; Wassmann Barbara; Tanaka Chiaki; Manley Paul; Rae Patricia; Mietlowski William; Bochinski Kathy; Hochhaus Andreas; Griffin James D; Hoelzer Dieter; Albitar Maher; Dugan Margaret; Cortes Jorge; Alland Leila; Ottmann Oliver G
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL.
The New England journal of medicine 2006;354(24):2542-51.
2006: Chen Zhengming; Lee Francis Y; Bhalla Kapil N; Wu Jie
Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib).
Molecular pharmacology 2006;69(5):1527-33.
2006: Basu Aruna; Castle Valerie P; Bouziane Mohammed; Bhalla Kapil; Haldar Subrata
Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family.
Cancer research 2006;66(8):4309-18.
2006: Chandra Joya; Tracy Jeannette; Loegering David; Flatten Karen; Verstovsek Srdan; Beran Miloslav; Gorre Mercedes; Estrov Zeev; Donato Nicholas; Talpaz Moshe; Sawyers Charles; Bhalla Kapil; Karp Judith; Sausville Edward; Kaufmann Scott H
Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance.
Blood 2006;107(6):2501-6.
2005: O'Brien Susan; Berman Ellin; Bhalla Kapil; Copelan Edward A; Devetten Marcel P; Emanuel Peter D; Erba Harry P; Greenberg Peter L; Moore Joseph O; Przepiorka Donna; Radich Jerald P; Schilder Russell J; Shami Paul; Smith B Douglas; Snyder David S; Soiffer Robert J; Tallman Martin S; Talpaz Moshe; Wetzler Meir
Chronic myelogenous leukemia.
Journal of the National Comprehensive Cancer Network : JNCCN 2005;3(6):732-55.
2005: Guo Fei; Rocha Kathy; Bali Purva; Pranpat Michael; Fiskus Warren; Boyapalle Sandhya; Kumaraswamy Sandhya; Balasis Maria; Greedy Benjamin; Armitage E Simon M; Lawrence Nicholas; Bhalla Kapil
Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin.
Cancer research 2005;65(22):10536-44.
2005: Chen Liwei; Meng Songshu; Wang Hai; Bali Purva; Bai Wenlong; Li Benyi; Atadja Peter; Bhalla Kapil N; Wu Jie
Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824.
Molecular cancer therapeutics 2005;4(9):1311-9.
2005: Bali Purva; Pranpat Michael; Swaby Ramona; Fiskus Warren; Yamaguchi Hirohito; Balasis Maria; Rocha Kathy; Wang Hong-Gang; Richon Victoria; Bhalla Kapil
Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6382-9.
2005: Swaby Ramona F; Bhalla Kapil N
Importance of rational pre-clinical development: gemcitabine comes of age.
Cancer biology & therapy 2005;4(8):872-3.
2005: Bali Purva; Pranpat Michael; Bradner James; Balasis Maria; Fiskus Warren; Guo Fei; Rocha Kathy; Kumaraswamy Sandhya; Boyapalle Sandhya; Atadja Peter; Seto Edward; Bhalla Kapil
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.
The Journal of biological chemistry 2005;280(29):26729-34.
2005: Bhalla Kapil N
Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(17):3971-93.
2005: George Prince; Bali Purva; Annavarapu Srinivas; Scuto Anna; Fiskus Warren; Guo Fei; Sigua Celia; Sondarva Gautam; Moscinski Lynn; Atadja Peter; Bhalla Kapil
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.
Blood 2005;105(4):1768-76.
2005: Wang Hongwei; Cheng Fengdong; Cuenca Alex; Horna Pedro; Zheng Zheng; Bhalla Kapil; Sotomayor Eduardo M
Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance.
Blood 2005;105(3):1135-43.
2005: Guo Fei; Sigua Celia; Bali Purva; George Prince; Fiskus Warren; Scuto Anna; Annavarapu Srinivas; Mouttaki Abdelmoughite; Sondarva Gautam; Wei Sheng; Wu Jie; Djeu Julie; Bhalla Kapil
Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.
Blood 2005;105(3):1246-55.
2005: Xu Rui-Hua; Pelicano Helene; Zhou Yan; Carew Jennifer S; Feng Li; Bhalla Kapil N; Keating Michael J; Huang Peng
Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.
Cancer research 2005;65(2):613-21.
2004: Bhalla Kapil; List Alan
Histone deacetylase inhibitors in myelodysplastic syndrome.
Best practice & research. Clinical haematology 2004;17(4):595-611.
2004: Staley Charles A; Harris Wayne B; Landry Jerome; Small William; Kooby David; Gillespie Theresa W; Meyers Mary; Bhalla Kapil N
Neoadjuvant induction chemotherapy followed by chemoradiation: a phase I trial of gemcitabine, cisplatin, and 5-fluorouracil for advanced pancreatic/gastrointestinal malignancies.
Surgical oncology clinics of North America 2004;13(4):697-709, x.
2004: Chawla R; Bhalla P; Garg S; Meghachandra Singh M; Bhalla K; Sodhani P; Sharma V K
Community based study on sero-prevalence of syphilis in New Delhi (India).
The Journal of communicable diseases 2004;36(3):205-11.
2004: Gasparetto Maura; Gentry Tracy; Sebti Said; O'Bryan Erica; Nimmanapalli Ramadevi; Blaskovich Michelle A; Bhalla Kapil; Rizzieri David; Haaland Perry; Dunne Jack; Smith Clay
Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screening.
Journal of immunological methods 2004;292(1-2):59-71.
2004: Yamaguchi Hirohito; Chen Jiandong; Bhalla Kapil; Wang Hong-Gang
Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways.
The Journal of biological chemistry 2004;279(38):39431-7.
2004: Bali Purva; George Prince; Cohen Pamela; Tao Jianguo; Guo Fei; Sigua Celia; Vishvanath Anasuya; Scuto Anna; Annavarapu Srinivas; Fiskus Warren; Moscinski Lynn; Atadja Peter; Bhalla Kapil
Superior activity of the combination of histone deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 against human acute myelogenous leukemia cells with mutant FLT-3.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):4991-7.
2004: George Prince; Bali Purva; Cohen Pamela; Tao Jianguo; Guo Fei; Sigua Celia; Vishvanath Anasuya; Fiskus Warren; Scuto Anna; Annavarapu Srinivas; Moscinski Lynn; Bhalla Kapil
Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.
Cancer research 2004;64(10):3645-52.
2004: Guo Fei; Sigua Celia; Tao Jianguo; Bali Purva; George Prince; Li Yunqing; Wittmann Sylvie; Moscinski Lynn; Atadja Peter; Bhalla Kapil
Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells.
Cancer research 2004;64(7):2580-9.
2004: Atadja Peter; Hsu Meier; Kwon Paul; Trogani Nancy; Bhalla Kapil; Remiszewski Stacy
Molecular and cellular basis for the anti-proliferative effects of the HDAC inhibitor LAQ824.
Novartis Foundation symposium 2004;259():249-66; discussion 266-8, 285-8.
2003: Bhalla Kapil N
Microtubule-targeted anticancer agents and apoptosis.
Oncogene 2003;22(56):9075-86.
2003: Nimmanapalli Ramadevi; Bali Purva; O'Bryan Erica; Fuino Lianne; Guo Fei; Wu Jie; Houghton Peter; Bhalla Kapil
Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells.
Cancer research 2003;63(22):7950-8.
2003: Fuino Lianne; Bali Purva; Wittmann Sylvie; Donapaty Sreenivas; Guo Fei; Yamaguchi Hirohito; Wang Hong-Gang; Atadja Peter; Bhalla Kapil
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B.
Molecular cancer therapeutics 2003;2(10):971-84.
2003: Sun Mei; Yang Lin; Feldman Richard I; Sun Xia-meng; Bhalla Kapil N; Jove Richard; Nicosia Santo V; Cheng Jin Q
Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src.
The Journal of biological chemistry 2003;278(44):42992-3000.
2003: Nimmanapalli Ramadevi; Fuino Lianne; Bali Purva; Gasparetto Maura; Glozak Michele; Tao Jianguo; Moscinski Lynn; Smith Clayton; Wu Jie; Jove Richard; Atadja Peter; Bhalla Kapil
Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.
Cancer research 2003;63(16):5126-35.
2003: Nimmanapalli Ramadevi; O'Bryan Erica; Kuhn Deborah; Yamaguchi Hirohito; Wang Hong-Gang; Bhalla Kapil N
Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases.
Blood 2003;102(1):269-75.
2003: Griffin David; Wittmann Sylvie; Guo Fei; Nimmanapalli Ramadevi; Bali Purva; Wang Hong Gang; Bhalla Kapil
Molecular determinants of epothilone B derivative (BMS 247550) and Apo-2L/TRAIL-induced apoptosis of human ovarian cancer cells.
Gynecologic oncology 2003;89(1):37-47.
2003: Yamaguchi Hirohito; Bhalla Kapil; Wang Hong-Gang
Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria.
Cancer research 2003;63(7):1483-9.
2003: Nimmanapalli Ramadevi; Fuino Lianne; Stobaugh Corinne; Richon Victoria; Bhalla Kapil
Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells.
Blood 2003;101(8):3236-9.
2003: Wittmann Sylvie; Bali Purva; Donapaty Sreenivasa; Nimmanapalli Ramadevi; Guo Fei; Yamaguchi Hirohito; Huang Mei; Jove Richard; Wang Hong Gang; Bhalla Kapil
Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.
Cancer research 2003;63(1):93-9.
2003: Nimmanapalli Ramadevi; Bhalla Kapil
Targets in apoptosis signaling: promise of selective anticancer therapy.
Methods in molecular biology (Clifton, N.J.) 2003;223():465-83.
2002: Huang Mei; Dorsey Jay F; Epling-Burnette P K; Nimmanapalli Ramadevi; Landowski Terry H; Mora Linda B; Niu Guilian; Sinibaldi Dominic; Bai Fanqi; Kraker Alan; Yu Hua; Moscinski Lynn; Wei Sheng; Djeu Julie; Dalton William S; Bhalla Kapil; Loughran Thomas P; Wu Jie; Jove Richard
Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells.
Oncogene 2002;21(57):8804-16.
2002: Nimmanapalli Ramadevi; Bhalla Kapil
Novel targeted therapies for Bcr-Abl positive acute leukemias: beyond STI571.
Oncogene 2002;21(56):8584-90.
2002: Nimmanapalli Ramadevi; Bhalla Kapil
Mechanisms of resistance to imatinib mesylate in Bcr-Abl-positive leukemias.
Current opinion in oncology 2002;14(6):616-20.
2002: Nimmanapalli Ramadevi; O'Bryan Erica; Huang Mei; Bali Purva; Burnette Pearlie Kay; Loughran Thomas; Tepperberg James; Jove Richard; Bhalla Kapil
Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin.
Cancer research 2002;62(20):5761-9.
2002: Guo Fei; Bhalla Kapil
The FLIP variation on the TRAIL DISC: doxorubicin conducts the swan song.
Cancer biology & therapy 2002;1(5):528-9.
2002: Dorsey J F; Cunnick J M; Lanehart R; Huang M; Kraker A J; Bhalla K N; Jove R; Wu J
Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(9):1589-95.
2002: Mukhopadhyay Asok; Shishodia Shishir; Suttles Jill; Brittingham Katherine; Lamothe Betty; Nimmanapalli Ramdevi; Bhalla Kapil N; Aggarwal Bharat B
Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors.
The Journal of biological chemistry 2002;277(34):30622-8.
2002: Guo Fei; Nimmanapalli Ramadevi; Paranawithana Shanthi; Wittman Sylvie; Griffin David; Bali Purva; O'Bryan Erica; Fumero Carlos; Wang Hong Gang; Bhalla Kapil
Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis.
Blood 2002;99(9):3419-26.
2002: O'Dwyer Michael E; La Rosée Paul; Nimmanapalli Ramedivi; Bhalla Kapil N; Druker Brian J
Recent advances in Philadelphia chromosome-positive malignancies: the potential role of arsenic trioxide.
Seminars in hematology 2002;39(2 Suppl 1):18-21.
2002: Yamaguchi Hirohito; Paranawithana Shanthi R; Lee Michael W; Huang Ziwei; Bhalla Kapil N; Wang Hong-Gang
Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells.
Cancer research 2002;62(2):466-71.
2001: Blagosklonny M V; Fojo T; Bhalla K N; Kim J S; Trepel J B; Figg W D; Rivera Y; Neckers L M
The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(10):1537-43.
2001: Porosnicu M; Nimmanapalli R; Nguyen D; Worthington E; Perkins C; Bhalla K N
Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(5):772-8.
2001: Nimmanapalli R; O'Bryan E; Bhalla K
Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts.
Cancer research 2001;61(5):1799-804.
2001: Nimmanapalli R; Porosnicu M; Nguyen D; Worthington E; O'Bryan E; Perkins C; Bhalla K
Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):350-7.
2001: Nimmanapalli R; Perkins C L; Orlando M; O'Bryan E; Nguyen D; Bhalla K N
Pretreatment with paclitaxel enhances apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels.
Cancer research 2001;61(2):759-63.
2000: Wen J; Ramadevi N; Nguyen D; Perkins C; Worthington E; Bhalla K
Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells.
Blood 2000;96(12):3900-6.
2000: Fang G; Kim C N; Perkins C L; Ramadevi N; Winton E; Wittmann S; Bhalla K N
CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs.
Blood 2000;96(6):2246-53.
2000: Perkins C L; Fang G; Kim C N; Bhalla K N
The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis.
Cancer research 2000;60(6):1645-53.
2000: Perkins C; Kim C N; Fang G; Bhalla K N
Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L).
Blood 2000;95(3):1014-22.
2000: Balachandran S; Roberts P C; Kipperman T; Bhalla K N; Compans R W; Archer D R; Barber G N
Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway.
Journal of virology 2000;74(3):1513-23.
2000: Cai J; Zheng T; Masood R; Smith D L; Hinton D R; Kim C N; Fang G; Bhalla K; Gill P S
Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells.
Sarcoma 2000;4(1-2):37-45.
1999: Bhalla K N; Kumar G N; Walle U K; Ibrado A M; Javed T; Stuart R K; Reed C; Arbuck S G; Walle T
Phase I and pharmacologic study of a 3-hour infusion of paclitaxel followed by cisplatinum and 5-fluorouracil in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1723-30.
1999: Kim C N; Bhalla K; Kreitman R J; Willingham M C; Hall P; Tagge E P; Jia T; Frankel A E
Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor and Ara-C exert synergistic toxicity against human AML HL-60 cells.
Leukemia research 1999;23(6):527-38.
1999: Han Z; Bhalla K; Pantazis P; Hendrickson E A; Wyche J H
Cif (Cytochrome c efflux-inducing factor) activity is regulated by Bcl-2 and caspases and correlates with the activation of Bid.
Molecular and cellular biology 1999;19(2):1381-9.
1999: Burri S H; Kim C N; Fang G; Chang B S; Perkins C; Harris W; Davis L W; Thompson C B; Bhalla K N
'Loop' domain deletional mutant of Bcl-xL is as effective as p29Bcl-xL in inhibiting radiation-induced cytosolic accumulation of cytochrome c (cyt c), caspase-3 activity, and apoptosis.
International journal of radiation oncology, biology, physics 1999;43(2):423-30.
1999: Yu Y; Black J B; Goldsmith C S; Browning P J; Bhalla K; Offermann M K
Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells.
The Journal of general virology 1999;80 ( Pt 1)():83-90.
1998: Ibrado A M; Kim C N; Bhalla K
Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(12):1930-6.
1998: Balachandran S; Kim C N; Yeh W C; Mak T W; Bhalla K; Barber G N
Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling.
The EMBO journal 1998;17(23):6888-902.
1998: Perkins C; Kim C N; Fang G; Bhalla K N
Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells.
Cancer research 1998;58(20):4561-6.
1998: Fang G; Chang B S; Kim C N; Perkins C; Thompson C B; Bhalla K N
"Loop" domain is necessary for taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting taxol-induced cytosolic accumulation of cytochrome c and apoptosis.
Cancer research 1998;58(15):3202-8.
1998: Ilson D H; Ajani J; Bhalla K; Forastiere A; Huang Y; Patel P; Martin L; Donegan J; Pazdur R; Reed C; Kelsen D P
Phase II trial of paclitaxel, fluorouracil, and cisplatin in patients with advanced carcinoma of the esophagus.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(5):1826-34.
1998: Bhalla K; Harris W B
Molecular and biologic determinants of neoadjuvant chemotherapy of locoregional breast cancer.
Seminars in oncology 1998;25(2 Suppl 3):19-24.
1998: Amarante-Mendes G P; Naekyung Kim C; Liu L; Huang Y; Perkins C L; Green D R; Bhalla K
Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3.
Blood 1998;91(5):1700-5.
1998: Fontana J A; Sun R J; Rishi A K; Dawson M I; Ordónez J V; Zhang Y; Tschang S H; Bhalla K; Han Z; Wyche J; Poirer G; Sheikh M S; Shroot B; Reichert U
Overexpression of bcl-2 or bcl-XL fails to inhibit apoptosis mediated by a novel retinoid.
Oncology research 1998;10(6):313-24.
1997: Frankel A E; Hall P D; Burbage C; Vesely J; Willingham M; Bhalla K; Kreitman R J
Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein.
Blood 1997;90(9):3654-61.
1997: Kim C N; Wang X; Huang Y; Ibrado A M; Liu L; Fang G; Bhalla K
Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis.
Cancer research 1997;57(15):3115-20.
1997: Ibrado A M; Liu L; Bhalla K
Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells.
Cancer research 1997;57(6):1109-15.
1997: Yang J; Liu X; Bhalla K; Kim C N; Ibrado A M; Cai J; Peng T I; Jones D P; Wang X
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.
Science (New York, N.Y.) 1997;275(5303):1129-32.
1997: Huang Y; Ibrado A M; Reed J C; Bullock G; Ray S; Tang C; Bhalla K
Co-expression of several molecular mechanisms of multidrug resistance and their significance for paclitaxel cytotoxicity in human AML HL-60 cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(2):253-7.
1997: Huang Y; Ray S; Reed J C; Ibrado A M; Tang C; Nawabi A; Bhalla K
Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells.
Breast cancer research and treatment 1997;42(1):73-81.
1996: Ray S; Bullock G; Nuñez G; Tang C; Ibrado A M; Huang Y; Bhalla K
Enforced expression of Bcl-XS induces differentiation and sensitizes chronic myelogenous leukemia-blast crisis K562 cells to 1-beta-D-arabinofuranosylcytosine-mediated differentiation and apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(12):1617-23.
1996: Bullock G; Ray S; Reed J C; Krajewski S; Ibrado A M; Huang Y; Bhalla K
Intracellular metabolism of Ara-C and resulting DNA fragmentation and apoptosis of human AML HL-60 cells possessing disparate levels of Bcl-2 protein.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(11):1731-40.
1996: Ibrado A M; Huang Y; Fang G; Liu L; Bhalla K
Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells.
Cancer research 1996;56(20):4743-8.
1996: Ibrado A M; Huang Y; Fang G; Bhalla K
Bcl-xL overexpression inhibits taxol-induced Yama protease activity and apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(8):1087-94.
1995: Ponnathpur V; Ibrado A M; Reed J C; Ray S; Huang Y; Self S; Bullock G; Nawabi A; Bhalla K
Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(11):1399-406.
1995: Agarwal B R; Bhalla K; Dalvi R; Currimbhoy Z E; Mehta K P
Myelofibrosis secondary to SLE and its reversal on steroid therapy.
Indian pediatrics 1995;32(11):1207-10.
1995: Bhalla K; Ibrado A M; Bradt J E; Ray S; Huang Y; Tang C; Nawabi A; Hoffman R
pIXY321 protects against Ara-C or taxol-induced apoptosis and loss of clonogenic survival of normal human bone marrow progenitor cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(11):1851-6.
1995: Agarwal B R; Gulvady A; Bhalla K; Dalvi R; Currimbhoy Z E
Treatment of aplastic anemia in children with high dose methyl prednisolone.
Indian pediatrics 1995;32(10):1061-5.
1995: Bullock G; Ray S; Reed J; Miyashita T; Maria Ibrado A; Huang Y; Bhalla K
Evidence against a direct role for the induction of c-jun expression in the mediation of drug-induced apoptosis in human acute leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(5):559-64.
1995: Walle T; Walle U K; Kumar G N; Bhalla K N
Taxol metabolism and disposition in cancer patients.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(4):506-12.
1995: Kumar G; Ray S; Walle T; Huang Y; Willingham M; Self S; Bhalla K
Comparative in vitro cytotoxic effects of taxol and its major human metabolite 6 alpha-hydroxytaxol.
Cancer chemotherapy and pharmacology 1995;36(2):129-35.
1994: Tang C; Huang Y; Ponnathpur V S; Ray S; Mahoney M E; Bullock G; Ibrado A M; Bhalla K
Combined antileukemic activity of pIXY 321 and Ara-C against human acute myeloid leukemia cells.
Leukemia & lymphoma 1994;15(5-6):445-51.
1994: Tang C; Willingham M C; Reed J C; Miyashita T; Ray S; Ponnathpur V; Huang Y; Mahoney M E; Bullock G; Bhalla K
High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(11):1960-9.
1994: Liu Y; Bhalla K; Hill C; Priest D G
Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in a human ovarian tumor cell line.
Biochemical pharmacology 1994;48(6):1265-72.
1994: Willingham M C; Bhalla K
Transient mitotic phase localization of bcl-2 oncoprotein in human carcinoma cells and its possible role in prevention of apoptosis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(4):441-50.
1994: Bhalla K; Huang Y; Tang C; Self S; Ray S; Mahoney M E; Ponnathpur V; Tourkina E; Ibrado A M; Bullock G
Characterization of a human myeloid leukemia cell line highly resistant to taxol.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(3):465-75.
1994: Brandt J E; Bhalla K; Hoffman R
Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells.
Blood 1994;83(6):1507-14.
1994: Ray S; Ponnathpur V; Huang Y; Tang C; Mahoney M E; Ibrado A M; Bullock G; Bhalla K
1-beta-D-arabinofuranosylcytosine-, mitoxantrone-, and paclitaxel-induced apoptosis in HL-60 cells: improved method for detection of internucleosomal DNA fragmentation.
Cancer chemotherapy and pharmacology 1994;34(5):365-71.
1993: Grant S; Baker M; Bhalla K
Phase I study of a continuous infusion of high-dose ara-C in conjunction with a fixed dose of 2'-deoxycytidine (IND 28108) in patients with refractory leukemia: an interim report.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(12):1933-8.
1993: Bullock G; Tang C; Tourkina E; Ibrado A M; Lutzky J; Huang Y; Mahoney M E; Bhalla K
Effect of combined treatment with interleukin-3 and interleukin-6 on 4-hydroperoxycyclo-phosphamide-induced programmed cell death or apoptosis in human myeloid leukemia cells.
Experimental hematology 1993;21(13):1640-7.
1993: Bhalla K; Ibrado A M; Tourkina E; Tang C; Grant S; Bullock G; Huang Y; Ponnathpur V; Mahoney M E
High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells.
Blood 1993;82(10):3133-40.
1993: Kumar G N; Walle U K; Bhalla K N; Walle T
Binding of taxol to human plasma, albumin and alpha 1-acid glycoprotein.
Research communications in chemical pathology and pharmacology 1993;80(3):337-44.
1993: Bhalla K; Ibrado A M; Tourkina E; Tang C; Mahoney M E; Huang Y
Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(4):563-8.
1993: Bhalla K; Ross R; Jeter E; Madyastha P; Stuart R
G-CSF improves granulocytopenia in Felty's syndrome without flare-up of arthritis.
American journal of hematology 1993;42(2):230-1.
1993: Bhalla K; Tourkina E; Huang Y; Tang C; Mahoney M E; Ibrado A M
Effect of hemopoietic growth factors G-CSF and pIXY 321 on the activity of high dose Ara-C in human myeloid leukemia cells.
Leukemia & lymphoma 1993;10 Suppl():123-31.
1992: Bhalla K; Tang C; Ibrado A M; Grant S; Tourkina E; Holladay C; Hughes M; Mahoney M E; Huang Y
Granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) enhances high-dose Ara-C-induced programmed cell death or apoptosis in human myeloid leukemia cells.
Blood 1992;80(11):2883-90.
1992: Bhalla K; Bullock G; Lutzky J; Holladay C; Ibrado A M; Jasiok M; Singh S
Effect of combined treatment with interleukin-3 and interleukin-6 on 4-hydroperoxycyclophosphamide-mediated reduction of glutathione levels and cytotoxicity in normal and leukemic bone marrow progenitor cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(8):814-9.
1992: Grant S; Traylor R; Bhalla K; McCrady C; Pettit G R
Effect of a combined exposure to cytosine arabinoside, bryostatin 1, and recombinant granulocyte-macrophage colony-stimulating factor on the clonogenic growth in vitro of normal and leukemic human hematopoietic progenitor cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(5):432-9.
1992: Bhalla K; Holladay C; Lutzky J; Ibrado A M; Bullock G; Jasiok M; Singh S
Deoxycytidine protects normal bone marrow progenitors against Ara-C and gemcitabine cytotoxicity without compromising their activity against cisplatin-resistant human ovarian cancer cells.
Gynecologic oncology 1992;45(1):32-9.
1991: Bhalla K; Birkhofer M; Bhalla M; Lutzky J; Hindenburg A; Cole J; Ince C
A phase I study of a combination of allopurinol, 5-fluorouracil and leucovorin followed by hydroxyurea in patients with advanced gastrointestinal and breast cancer.
American journal of clinical oncology 1991;14(6):509-13.
1991: Bhalla K; Swerdlow P; Grant S
Effects of thymidine and hydroxyurea on the metabolism and cytotoxicity of 1-B-D arabinofuranosylcytosine in highly resistant human leukemia cells.
Blood 1991;78(11):2937-44.
1991: Bhalla K; Holladay C; Arlin Z; Grant S; Ibrado A M; Jasiok M
Treatment with interleukin-3 plus granulocyte-macrophage colony-stimulating factors improves the selectivity of Ara-C in vitro against acute myeloid leukemia blasts.
Blood 1991;78(10):2674-9.
1991: Bhalla K; Birkhofer M; Arlin Z; Grant S; Lutzky J; Safah H; Graham G
Differential effect of interleukin 3 on the metabolism of high-dose cytosine arabinoside in normal versus leukemic human bone marrow cells.
Experimental hematology 1991;19(7):669-73.
1991: Grant S; Bhalla K; McCrady C
Effect of tetrahydrouridine and deoxytetrahydrouridine on the interaction between 2'-deoxycytidine and 1-beta-D-arabinofuranosylcytosine in human leukemia cells.
Leukemia research 1991;15(4):205-13.
1991: Gervasoni J E; Taub R N; Rosado M; Krishna S; Stewart V J; Knowles D M; Bhalla K; Ross D D; Baker M A; Lutzky J
Membrane glycoprotein changes associated with anthracycline resistance in HL-60 cells.
Cancer chemotherapy and pharmacology 1991;28(2):93-101.
1990: Bhalla K N; Li G R; Grant S; Cole J T; MacLaughlin W W; Volsky D J
The effect in vitro of 2'-deoxycytidine on the metabolism and cytotoxicity of 2',3'-dideoxycytidine.
AIDS (London, England) 1990;4(5):427-31.
1990: Grant S; Bhalla K; Arlin Z; Howe C W
The effect of a prolonged in vitro exposure to 1-beta-D arabinofuranosylcytosine and deoxycytidine on the survival of normal (CFU-GM) and leukemic (L-CFU) human myeloid progenitor cells in suspension culture.
Experimental hematology 1990;18(1):41-8.
1989: Bhalla K; Birkhofer M; Li G R; Grant S; MacLaughlin W; Cole J; Graham G; Volsky D J
2'-Deoxycytidine protects normal human bone marrow progenitor cells in vitro against the cytotoxicity of 3'-azido-3'-deoxythymidine with preservation of antiretroviral activity.
Blood 1989;74(6):1923-8.
1989: Lutzky J; Astor M B; Taub R N; Baker M A; Bhalla K; Gervasoni J E; Rosado M; Stewart V; Krishna S; Hindenburg A A
Role of glutathione and dependent enzymes in anthracycline-resistant HL60/AR cells.
Cancer research 1989;49(15):4120-5.
1989: Hindenburg A A; Gervasoni J E; Krishna S; Stewart V J; Rosado M; Lutzky J; Bhalla K; Baker M A; Taub R N
Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells.
Cancer research 1989;49(16):4607-14.
1989: Bhalla K; Birkhofer M; Grant S; Graham G
The effect of recombinant human granulocyte-macrophage colony-stimulating factor (rGM-CSF) on 3'-azido-3'-deoxythymidine (AZT)-mediated biochemical and cytotoxic effects on normal human myeloid progenitor cells.
Experimental hematology 1989;17(1):17-20.
1988: Bhalla K; Birkhofer M; Arlin Z; Grant S; Lutzky J; Graham G
Effect of recombinant GM-CSF on the metabolism of cytosine arabinoside in normal and leukemic human bone marrow cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(12):810-3.
1988: Bhalla K; Birkhofer M; Grant S; Baker M; MacLaughlin W; Cole J; Graham G
Phase I clinical and pharmacologic study of deoxycytidine.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(10):709-10.
1987: Bhalla K; Cole J; MacLaughlin W; Arlin Z; Baker M; Graham G; Grant S
Effect of deoxycytidine on the metabolism and cytotoxicity of 5-aza-2'-deoxycytidine and arabinosyl 5-azacytosine in normal and leukemic human myeloid progenitor cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(12):814-9.
1987: Bhalla K; MacLaughlin W; Cole J; Arlin Z; Baker M; Graham G; Grant S
Deoxycytidine preferentially protects normal versus leukemic myeloid progenitor cells from cytosine arabinoside-mediated cytotoxicity.
Blood 1987;70(2):568-71.
1987: Bhalla K; Grant S
Effect of deoxycytidine on the in vitro response of human leukemia cells to inhibitors of de novo pyrimidine biosynthesis.
Cancer chemotherapy and pharmacology 1987;19(3):226-32.
1986: Bhalla K; Cole J; MacLaughlin W; Baker M; Arlin Z; Graham G; Grant S
Deoxycytidine stimulates the in vitro growth of normal CFU-GM and reverses the negative regulatory effects of acidic isoferritin and prostaglandin E1.
Blood 1986;68(5):1136-41.
1986: Grant S; Bhalla K; Gleyzer M
Interaction of deoxycytidine and deoxycytidine analogs in normal and leukemic human myeloid progenitor cells.
Leukemia research 1986;10(9):1139-46.
1985: Bhalla K; Hindenburg A; Taub R N; Grant S
Isolation and characterization of an anthracycline-resistant human leukemic cell line.
Cancer research 1985;45(8):3657-62.
1985: Grant S; Bhalla K; Weinstein B; Pestka S; Mileno M D; Fisher P B
Recombinant human interferon sensitizes resistant myeloid leukemic cells to induction of terminal differentiation.
Biochemical and biophysical research communications 1985;130(1):379-88.
1984: Grant S; Bhalla K; Gleyzer M
Effect of uridine on response of 5-azacytidine-resistant human leukemic cells to inhibitors of de novo pyrimidine synthesis.
Cancer research 1984;44(12 Pt 1):5505-10.
1984: Bhalla K; Nayak R; Grant S
Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine.
Cancer research 1984;44(11):5029-37.
1984: Bhalla K; Nayak R; Deitch A; Grant S
Synergistic interaction between acivicin (AT-125) and 6-thioguanine in the murine leukemia L1210. Biochemical and cytokinetic considerations.
Biochemical pharmacology 1984;33(2):247-54.
1983: Grant S; Bhalla K; Rauscher F; Cadman E
Potentiation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity by 2,3-dihydro-1H-imidazolo[1,2-b]pyrazole in the human promyelocytic leukemic cell, HL-60.
Cancer research 1983;43(11):5093-100.
1982: Grant S; Bhalla K; Weinstein I B; Pestka S; Fisher P B
Differential effect of recombinant human leukocyte interferon on human leukemic and normal myeloid progenitor cells.
Biochemical and biophysical research communications 1982;108(3):1048-55.

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