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Phillip Chandler

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Babak Baban; Bruce R Blazar; Phillip R Chandler; Loise M Francisco; Lei Huang; Burles A Johnson; Minghui Li; David H Munn; Arlene H Sharpe; Marlon L Sharpe; Andrew L Mellor
Physiologic control of IDO competence in splenic dendritic cells.
Levi Makala; Babak Baban; Henrique Lemos; Ahmed R El-Awady; Phillip R Chandler; Deyan Hou; David H Munn; Andrew L Mellor
Leishmania major attenuates host immunity by stimulating local indoleamine 2,3-dioxygenase expression.
Madhav D Sharma; Deyan Hou; Babak Baban; Pandelakis Koni; Yukai He; Phillip R Chandler; Bruce R Blazar; Andrew L Mellor; David H Munn
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.

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2011: Babak Baban; Bruce R Blazar; Phillip R Chandler; Loise M Francisco; Lei Huang; Burles A Johnson; Minghui Li; David H Munn; Arlene H Sharpe; Marlon L Sharpe; Andrew L Mellor
Physiologic control of IDO competence in splenic dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2329-35.
2011: Levi Makala; Babak Baban; Henrique Lemos; Ahmed R El-Awady; Phillip R Chandler; Deyan Hou; David H Munn; Andrew L Mellor
Leishmania major attenuates host immunity by stimulating local indoleamine 2,3-dioxygenase expression.
The Journal of infectious diseases 2011;203(5):715-25.
2010: Madhav D Sharma; Deyan Hou; Babak Baban; Pandelakis Koni; Yukai He; Phillip R Chandler; Bruce R Blazar; Andrew L Mellor; David H Munn
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.
Immunity 2010;33(6):942-54.
2010: Qifeng Zhou; Haiyan Xiao; Yanjun Liu; Yibing Peng; Yuan Hong; Hideo Yagita; Phillip R Chandler; David H Munn; Andrew L Mellor; Ning Fu; Yukai He
Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(9):5082-92.
2010: Burles A Johnson; David J Kahler; Babak Baban; Phillip R Chandler; Baolin Kang; Michiko Shimoda; Pandelakis Koni; Jeanene Pihkala; Bojan Vilagos; Meinrad Busslinger; David H Munn; Andrew L Mellor
B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10644-8.
2010: Mary Zimmerman; Dafeng Yang; Xiaolin Hu; Feiyan Liu; Nagendra Singh; Darren Browning; Vadivel Ganapathy; Phillip R Chandler; Divaker Choubey; Scott I Abrams; Kebin Liu
IFN-γ upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells.
PloS one 2010;5(11):e14076.
2009: Babak Baban; Phillip R Chandler; Madhav D Sharma; Jeanene P S Pihkala; Pandelakis Koni; David H Munn; Andrew L Mellor
IDO activates regulatory T cells and blocks their conversion into Th17-like T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2475-83.
2009: Madhav D Sharma; Deyan Hou; Yanjun Liu; Pandelakis Koni; Richard Metz; Phillip R Chandler; Andrew L Mellor; Yukai He; David H Munn
Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.
Blood 2009;113(24):6102-11.
2008: Alexander J Muller; Madhav D Sharma; Phillip R Chandler; James B DuHadaway; Mary E Everhart; Burles A Johnson; David J Kahler; Jeanene P S Pihkala; Alejandro Peralta Soler; David H Munn; George C Prendergast; Andrew L Mellor
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):17073-8.
2007: Madhav D Sharma; Babak Baban; Phillip R Chandler; Deyan Hou; Nagendra Singh; Hideo Yagita; Miyuki Azuma; Bruce R Blazar; Andrew L Mellor; David H Munn
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase.
The Journal of clinical investigation 2007;117(9):2570-82.
2007: Nagendra Singh; Phillip R Chandler; Yoichi Seki; Babak Baban; Mayuko Takezaki; David J Kahler; David H Munn; Christian P Larsen; Andrew L Mellor; Makio Iwashima
Role of CD28 in fatal autoimmune disorder in scurfy mice.
Blood 2007;110(4):1199-206.
2007: Anna Manlapat; David J Kahler; Phillip R Chandler; David H Munn; Andrew L Mellor
Cell-autonomous control of interferon type I expression by indoleamine 2,3-dioxygenase in regulatory CD19+ dendritic cells.
European journal of immunology 2007;37(4):1064-71.
2006: Nagendra Singh; Yoichi Seki; Mariko Takami; Babak Baban; Phillip R Chandler; Davood Khosravi; Xiangjian Zheng; Mayuko Takezaki; Jeffrey R Lee; Andrew L Mellor; Wendy B Bollag; Makio Iwashima
Enrichment of regulatory CD4(+)CD25(+) T cells by inhibition of phospholipase D signaling.
Nature methods 2006;3(8):629-36.
2005: Andrew L Mellor; Babak Baban; Phillip R Chandler; Anna Manlapat; David J Kahler; David H Munn
Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5601-5.
2005: Babak Baban; Anna M Hansen; Phillip R Chandler; Anna Manlapat; Adam Bingaman; David J Kahler; David H Munn; Andrew L Mellor
A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation.
International immunology 2005;17(7):909-19.
2004: Andrew L Mellor; Phillip R Chandler; Babak Baban; Anna M Hansen; Brendan Marshall; Jeanene P S Pihkala; Herman Waldmann; Stephen P Cobbold; Elizabeth Adams; David H Munn
Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase.
International immunology 2004;16(10):1391-401.
2004: David H Munn; Madhav D Sharma; Deyan Hou; Babak Baban; Jeffrey R Lee; Scott J Antonia; Jane L Messina; Phillip R Chandler; Pandelakis Koni; Andrew L Mellor
Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.
The Journal of clinical investigation 2004;114(2):280-90.
2004: Babak Baban; Phillip R Chandler; Doris McCool; Brendan Marshall; David H Munn; Andrew L Mellor
Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific.
Journal of reproductive immunology 2004;61(2):67-77.
2003: Andrew L Mellor; Babak Baban; Phillip R Chandler; Brendan Marshall; Kanchan Jhaver; Anna Hansen; Pandelakis Koni; Makio Iwashima; David H Munn
Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1652-5.
2003: Toru Koike; Hiroko Yamagishi; Yasue Hatanaka; Atsuki Fukushima; Jing-wen Chang; Yan Xia; Mark A Fields; Phillip R Chandler; Makio Iwashima
A novel ERK-dependent signaling process that regulates interleukin-2 expression in a late phase of T cell activation.
The Journal of biological chemistry 2003;278(18):15685-92.
2003: Andrew L Mellor; David H Munn; Phillip R Chandler; Derin B Keskin; Theodore M Johnson; Brendan Marshall; Kanchan Jhaver; Babak Baban
Tryptophan catabolism and T cell responses.
Advances in experimental medicine and biology 2003;527():27-35.
2002: Geon Kook Lee; Hyeon Jin Park; Megan Macleod; Phillip R Chandler; David H Munn; Andrew L Mellor
Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division.
Immunology 2002;107(4):452-60.
2002: Edward James; Diane Scott; Jian-Guo Chai; Maggie Millrain; Phillip R Chandler; Elizabeth Simpson
HY peptides modulate transplantation responses to skin allografts.
International immunology 2002;14(11):1333-42.
2002: Andrew L Mellor; Phillip R Chandler; Geon Kook Lee; Theodore M Johnson; Derin B Keskin; Jeffrey R Lee; David H Munn
Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy.
Journal of reproductive immunology 2002;57(1-2):143-50.
2002: David H Munn; Madhav D Sharma; Jeffrey R Lee; Kanchan Jhaver; Theodore S Johnson; Derin B Keskin; Brendan Marshall; Phillip R Chandler; Scott J Antonia; Russell Burgess; Craig L Slingluff; Andrew L Mellor
Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase.
Science (New York, N.Y.) 2002;297(5588):1867-70.
2002: Andrew L Mellor; Derin B Keskin; Theodore M Johnson; Phillip R Chandler; David H Munn
Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3771-6.
2001: Maggie Millrain; Phillip R Chandler; Francesco Dazzi; Diane Scott; Elizabeth Simpson; PJ Dyson
Examination of HY response: T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3756-64.
2001: Stipo Jurcevic; Phillip R Chandler; Steven H Sacks; Elizabeth Simpson
Rapid rejection of HLA-A2 transgenic skin graft due to indirect allorecognition.
Transplantation 2001;72(6):994-7.
2001: Andrew L Mellor; J Sivakumar; Phillip R Chandler; K Smith; H Molina; D Mao; David H Munn
Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy.
Nature immunology 2001;2(1):64-8.
2000: C Rivas; Phillip R Chandler; J V Melo; E Simpson; J F Apperley
Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T lymphoma.
Cancer gene therapy 2000;7(6):954-62.
2000: Michelle E K Haywood; MB Hogarth; JH Slingsby; S Jane Rose; P J Allen; EM Thompson; M A Maibaum; Phillip R Chandler; Kevin A Davies; E Simpson; Mark J Walport; Bernard J Morley
Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice.
Arthritis and rheumatism 2000;43(2):349-55.
1999: Kanchan Jhaver; Phillip R Chandler; E Simpson; Andrew L Mellor
Thymocyte antigens do not induce tolerance in the CD4+ T cell compartment.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4851-8.
1999: Jian-Guo Chai; Istvan Bartok; Phillip R Chandler; S Vendetti; A Antoniou; Julian Dyson; Robert Lechler
Anergic T cells act as suppressor cells in vitro and in vivo.
European journal of immunology 1999;29(2):686-92.
1998: MB Hogarth; JH Slingsby; P J Allen; EM Thompson; Phillip R Chandler; Kevin A Davies; E Simpson; Bernard J Morley; Mark J Walport
Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):2753-61.
1998: Diana Zelenika; Elizabeth Adams; Andrew L Mellor; E Simpson; Phillip R Chandler; B Stockinger; Herman Waldmann; Stephen P Cobbold
Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: no requirement for CD8+ T cells or B cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1868-74.
1997: K Takács; Phillip R Chandler; Daniel M Altmann
Relapsing and remitting experimental allergic encephalomyelitis: a focused response to the encephalitogenic peptide rather than epitope spread.
European journal of immunology 1997;27(11):2927-34.
1997: LA Cotterill; H J Stauss; Maggie Millrain; Darryl Pappin; Dinah Rahman; Benito Canas; Phillip R Chandler; A Stackpoole; Elizabeth Simpson; P J Robinson; PJ Dyson
Qa-1 interaction and T cell recognition of the Qa-1 determinant modifier peptide.
European journal of immunology 1997;27(9):2123-32.
1997: D M Scott; IE Ehrmann; PS Ellis; Phillip R Chandler; Elizabeth Simpson
Why do some females reject males? The molecular basis for male-specific graft rejection.
Journal of molecular medicine (Berlin, Germany) 1997;75(2):103-14.
1997: Elizabeth Simpson; D Scott; Phillip R Chandler
The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning.
Annual review of immunology 1997;15():39-61.
1996: Antony N Antoniou; D McCormick; D Scott; H Yeoman; Phillip R Chandler; Andrew L Mellor; Julian Dyson
T cell tolerance and activation to a transgene-encoded tumor antigen.
European journal of immunology 1996;26(5):1094-102.
1996: R A Hederer; Phillip R Chandler; P J Dyson; Antony N Antoniou; Maggie Millrain; Andrew L Mellor; Elizabeth Simpson; P J Robinson
Acceptance of skin grafts between mice bearing different allelic forms of beta 2-microglobulin.
Transplantation 1996;61(2):299-304.
1996: Clio Mamalaki; M Murdjeva; Mauro Tolaini; Trisha Norton; Phillip R Chandler; A Townsend; Elizabeth Simpson; Dimitris Kioussis
Tolerance in TCR/cognate antigen double-transgenic mice mediated by incomplete thymic deletion and peripheral receptor downregulation.
Developmental immunology 1996;4(4):299-315.
1995: Elizabeth Simpson; Phillip R Chandler; Anne_Marit Sponaas; Maggie Millrain; P J Dyson
T cells with dual antigen specificity in T cell receptor transgenic mice rejecting allografts.
European journal of immunology 1995;25(10):2813-7.
1995: Phillip R Chandler; A J Frater; D C Douek; J L Viney; G Kay; MJ Owen; Adrian C Hayday; Elizabeth Simpson; Daniel M Altmann
Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells.
Immunology 1995;85(4):531-7.
1995: D Healey; P Ozegbe; S Arden; Phillip R Chandler; J Hutton; Anne Cooke
In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice.
The Journal of clinical investigation 1995;95(6):2979-85.
1995: R Quartey-Papafio; T Lund; Phillip R Chandler; J Picard; P Ozegbe; S Day; Patricia Hutchings; L O'Reilly; D Kioussis; Elizabeth Simpson
Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5567-75.
1994: Francesco Colucci; U Dahl; L O'Reilly; Anne Cooke; Phillip R Chandler; Elizabeth Simpson; T Matsunaga
Non-diabetogenic insulitis in NOD<-->B10.GD allophenic mice in spite of permissive class I MHC antigens.
Scandinavian journal of immunology 1994;40(6):659-64.
1994: L A O'Reilly; D Healey; Elizabeth Simpson; Phillip R Chandler; T Lund; M A Ritter; Anne Cooke
Studies on the thymus of non-obese diabetic (NOD) mice: effect of transgene expression.
Immunology 1994;82(2):275-86.
1994: Elizabeth Simpson; P J Robinson; Phillip R Chandler; Maggie Millrain; H P Pircher; D Brändle; P Tomlinson; J Antoniou; Andrew L Mellor
Separation of thymic education from antigen presenting functions of major histocompatibility complex class I molecules.
Immunology 1994;81(1):132-6.
1993: Nicole Parish; Phillip R Chandler; R Quartey-Papafio; Elizabeth Simpson; Anne Cooke
The effect of bone marrow and thymus chimerism between non-obese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes.
European journal of immunology 1993;23(10):2667-75.
1993: Clio Mamalaki; Y Tanaka; P Corbella; Phillip R Chandler; Elizabeth Simpson; Dimitris Kioussis
T cell deletion follows chronic antigen specific T cell activation in vivo.
International immunology 1993;5(10):1285-92.
1993: Elizabeth Simpson; Phillip R Chandler; E Goulmy; K Ma; T B Hargreave; A C Chandley
Loss of the 'azoospermia factor' (AZF) on Yq in man is not associated with loss of HYA.
Human molecular genetics 1993;2(4):469-71.
1993: Clio Mamalaki; J Elliott; Trisha Norton; N Yannoutsos; A R Townsend; Phillip R Chandler; Elizabeth Simpson; Dimitris Kioussis
Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen.
Developmental immunology 1993;3(3):159-74.
1992: Clio Mamalaki; Trisha Norton; Y Tanaka; A R Townsend; Phillip R Chandler; Elizabeth Simpson; Dimitris Kioussis
Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11342-6.
1992: S D Husbands; G Schönrich; Bernd Arnold; Phillip R Chandler; Elizabeth Simpson; K L Philpott; P Tomlinson; L O'Reilly; Anne Cooke; Andrew L Mellor
Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non-deletional mechanism.
European journal of immunology 1992;22(10):2655-61.
1992: A J O'Reilly; Nabeel A Affara; Elizabeth Simpson; Phillip R Chandler; E Goulmy; Malcolm A Ferguson-Smith
A molecular deletion map of the Y chromosome long arm defining X and autosomal homologous regions and the localisation of the HYA locus to the proximal region of the Yq euchromatin.
Human molecular genetics 1992;1(6):379-85.
1991: Elizabeth Simpson; J Farrant; Phillip R Chandler
Phenotypic and functional studies of human peripheral blood lymphocytes engrafted in scid mice.
Immunological reviews 1991;124():97-111.
1991: Andrew L Mellor; P D Tomlinson; J Antoniou; Phillip R Chandler; P Robinson; M Felstein; J Sloan; A Edwards; L O'Reilly; Anne Cooke
Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice.
International immunology 1991;3(5):493-502.
1990: T Lund; L O'Reilly; Patricia Hutchings; O Kanagawa; Elizabeth Simpson; R Gravely; Phillip R Chandler; Julian Dyson; J K Picard; A Edwards
Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain.
Nature 1990;345(6277):727-9.
1988: Phillip R Chandler; SP Fairchild; Elizabeth Simpson
H-Y responses of non-obese diabetic (NOD) mice.
Journal of immunogenetics 1988;15(5-6):321-30.
1987: Elizabeth Simpson; Phillip R Chandler; A McLaren; E Goulmy; C M Disteche; D C Page; M A Ferguson-Smith
Mapping the H-Y gene.
Development (Cambridge, England) 1987;101 Suppl():157-61.