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Ian Chambers

Research Profile

Living Beings

Mouse

Anatomy

Chemicals & Drugs

Physiology

Procedures

Nuclear Reprogramming

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Publications

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Violetta Karwacki-Neisius; Nicholas P Mullin; Huck-Hui Ng; Jia Hui Ng; Rodrigo Osorno; Simon R Tomlinson; Andrea Y Weiße; Frederick C K Wong; Douglas Colby; Nicola Festuccia; Alessia Gagliardi; Jonathan Göke; Florian Halbritter; Ian Chambers
Reduced oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by oct4 and nanog.
Pablo Navarro; Rodrigo Osorno; Morag Robertson; Wensheng Zhang; Douglas Colby; Nicola Festuccia; Alessia Gagliardi; Violetta Karwacki-Neisius; David Kelly; Nicholas P Mullin; Ian Chambers
OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.
Nicola Festuccia; Florian Halbritter; Violetta Karwacki-Neisius; Pablo Navarro; Rodrigo Osorno; Simon R Tomlinson; Frederick Wong; Adam Yates; Douglas Colby; Ian Chambers
Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells.

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All Publications

2013: Violetta Karwacki-Neisius; Nicholas P Mullin; Huck-Hui Ng; Jia Hui Ng; Rodrigo Osorno; Simon R Tomlinson; Andrea Y Weiße; Frederick C K Wong; Douglas Colby; Nicola Festuccia; Alessia Gagliardi; Jonathan Göke; Florian Halbritter; Ian Chambers
Reduced oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by oct4 and nanog.
Cell stem cell 2013;12(5):531-45.
2012: Pablo Navarro; Rodrigo Osorno; Morag Robertson; Wensheng Zhang; Douglas Colby; Nicola Festuccia; Alessia Gagliardi; Violetta Karwacki-Neisius; David Kelly; Nicholas P Mullin; Ian Chambers
OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.
The EMBO journal 2012;31(24):4547-62.
2012: Nicola Festuccia; Florian Halbritter; Violetta Karwacki-Neisius; Pablo Navarro; Rodrigo Osorno; Simon R Tomlinson; Frederick Wong; Adam Yates; Douglas Colby; Ian Chambers
Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells.
Cell stem cell 2012;11(4):477-90.
2012: Ian Chambers; Timm Schroeder
Stem cell powwow in Squaw Valley.
Development (Cambridge, England) 2012;139(14):2457-61.
2012: Rodrigo Osorno; Paul J Scotting; Anestis Tsakiridis; Ronald Wilkie; Guillaume Blin; Noemí Cambray; Ian Chambers; Constantinos Economou; Frederick Wong; Valerie Wilson
The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression.
Development (Cambridge, England) 2012;139(13):2288-98.
2011: Nicola Festuccia; Ian Chambers
Quantification of pluripotency transcription factor levels in embryonic stem cells by flow cytometry.
Current protocols in stem cell biology 2011;Chapter 1():Unit 1B.9.
2011: Rodrigo Osorno; Ian Chambers
Transcription factor heterogeneity and epiblast pluripotency.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1575):2230-7.
2011: Ian Wilmut; Gareth J Sullivan; Ian Chambers
The evolving biology of cell reprogramming.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1575):2183-97.
2011: Pablo Navarro; Michael Moffat; Nicholas P Mullin; Ian Chambers
The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells.
Human genetics 2011;130(2):255-64.
2010: Pablo Navarro; Ian Chambers
Is the umbilical cord a lifeline for regenerative therapy?
Cell cycle (Georgetown, Tex.) 2010;9(8):1464.
2009: Anestis Tsakiridis; Elena Tzouanacou; Afifah Rahman; Douglas Colby; Richard Axton; Ian Chambers; Valerie Wilson; Lesley Forrester; Joshua M Brickman
Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells.
Nucleic acids research 2009;37(19):e129.
2009: Jose Silva; Jennifer Nichols; Thorold W Theunissen; Ge Guo; Anouk L van Oosten; Ornella Barrandon; Jason Wray; Shinya Yamanaka; Ian Chambers; Austin Smith
Nanog is the gateway to the pluripotent ground state.
Cell 2009;138(4):722-37.
2009: Ian Chambers; Simon R Tomlinson
The transcriptional foundation of pluripotency.
Development (Cambridge, England) 2009;136(14):2311-22.
2008: Nicholas P Mullin; Adam Yates; Arthur J Rowe; Bianca Nijmeijer; Douglas Colby; Paul N Barlow; Malcolm D Walkinshaw; Ian Chambers
The pluripotency rheostat Nanog functions as a dimer.
The Biochemical journal 2008;411(2):227-31.
2007: Ian Chambers; Jose Silva; Douglas Colby; Jennifer Nichols; Bianca Nijmeijer; Morag Robertson; Jan Vrana; Ken Jones; Lars Grotewold; Austin Smith
Nanog safeguards pluripotency and mediates germline development.
Nature 2007;450(7173):1230-4.
2006: Morag Robertson; Frances Stenhouse; Douglas Colby; Jamie R K Marland; Jennifer Nichols; Susan Tweedie; Ian Chambers
Nanog retrotransposed genes with functionally conserved open reading frames.
Mammalian genome : official journal of the International Mammalian Genome Society 2006;17(7):732-43.
2006: Jose Silva; Ian Chambers; Steven Pollard; Austin Smith
Nanog promotes transfer of pluripotency after cell fusion.
Nature 2006;441(7096):997-1001.
2005: A Yates; Ian Chambers
The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells.
Biochemical Society transactions 2005;33(Pt 6):1518-21.
2005: A A Fouladi-Nashta; C J P Jones; N Nijjar; L Mohamet; A Smith; Ian Chambers; Susan J Kimber
Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice.
Developmental biology 2005;281(1):1-21.
2004: Ian Chambers; Austin Smith
Self-renewal of teratocarcinoma and embryonic stem cells.
Oncogene 2004;23(43):7150-60.
2004: J R A Sherwin; Tom C Freeman; R J Stephens; Susan J Kimber; A G Smith; Ian Chambers; Stephen K Smith; Andrew M Sharkey
Identification of genes regulated by leukemia-inhibitory factor in the mouse uterus at the time of implantation.
Molecular endocrinology (Baltimore, Md.) 2004;18(9):2185-95.
2004: Ian Chambers
The molecular basis of pluripotency in mouse embryonic stem cells.
Cloning and stem cells 2004;6(4):386-91.
2003: Qi-Long Ying; Jennifer Nichols; Ian Chambers; Austin Smith
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3.
Cell 2003;115(3):281-92.
2003: Ian Chambers; Douglas Colby; Morag Robertson; Jennifer Nichols; Sonia Lee; Susan Tweedie; Austin Smith
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.
Cell 2003;113(5):643-55.
2003: Giuseppe Testa; Youming Zhang; Kristina Vintersten; Vladimir Benes; W W M Pim Pijnappel; Ian Chambers; Andrew J H Smith; Austin G Smith; A Francis Stewart
Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles.
Nature biotechnology 2003;21(4):443-7.
2002: Jerôme Aubert; Hannah Dunstan; Ian Chambers; Austin Smith
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation.
Nature biotechnology 2002;20(12):1240-5.
2002: Hitoshi Niwa; Shinji Masui; Ian Chambers; Austin G Smith; Jun-ichi Miyazaki
Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.
Molecular and cellular biology 2002;22(5):1526-36.
2001: Jennifer Nichols; Ian Chambers; T Taga; Austin Smith
Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines.
Development (Cambridge, England) 2001;128(12):2333-9.
1999: T Burdon; C Stracey; Ian Chambers; Jennifer Nichols; Austin Smith
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.
Developmental biology 1999;210(1):30-43.
1999: T Burdon; Ian Chambers; C Stracey; H Niwa; Austin Smith
Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells.
Cells, tissues, organs 1999;165(3-4):131-43.
1998: C Dani; Ian Chambers; S Johnstone; Morag Robertson; Bahram Ebrahimi; M Saito; T Taga; Meng Li; T Burdon; Jennifer Nichols; Austin Smith
Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway.
Developmental biology 1998;203(1):149-62.
1998: Jennifer Nichols; B Zevnik; Konstantinos Anastassiadis; H Niwa; D Klewe-Nebenius; Ian Chambers; Heinz F Schöler; Austin Smith
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.
Cell 1998;95(3):379-91.
1998: H Niwa; T Burdon; Ian Chambers; Austin Smith
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.
Genes & development 1998;12(13):2048-60.
1997: Ian Chambers; A Cozens; J Broadbent; Morag Robertson; M Lee; Meng Li; Austin Smith
Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5' untranslated region.
The Biochemical journal 1997;328 ( Pt 3)():879-88.
1996: Jennifer Nichols; D Davidson; Tetsuya Taga; Kanji Yoshida; Ian Chambers; Austin Smith
Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis.
Mechanisms of development 1996;57(2):123-31.
1994: Jennifer Nichols; Ian Chambers; Austin Smith
Derivation of germline competent embryonic stem cells with a combination of interleukin-6 and soluble interleukin-6 receptor.
Experimental cell research 1994;215(1):237-9.
1994: P Mountford; B Zevnik; A Düwel; Jennifer Nichols; Meng Li; C Dani; Morag Robertson; Ian Chambers; Austin Smith
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4303-7.
1994: Kanji Yoshida; Ian Chambers; Jennifer Nichols; Austin Smith; M Saito; K Yasukawa; M Shoyab; Tetsuya Taga; Tadamitsu Kishimoto
Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways.
Mechanisms of development 1994;45(2):163-71.
1993: Jim O'Prey; S Ramsay; Ian Chambers; Paul R Harrison
Transcriptional up-regulation of the mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3' enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors.
Molecular and cellular biology 1993;13(10):6290-303.
1993: Morag Robertson; Ian Chambers; P Rathjen; Jennifer Nichols; Austin Smith
Expression of alternative forms of differentiation inhibiting activity (DIA/LIF) during murine embryogenesis and in neonatal and adult tissues.
Developmental genetics 1993;14(3):165-73.