Arthur Vandenbark

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Vandenbark Arthur A; Huan Jianya; Agotsch Marisa; La Tocha Dorian; Goelz Susan; Offner Halina; Lanker Stefan; Bourdette Dennis
Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis.
Subramanian Sandhya; Zhang Bing; Kosaka Yasuharu; Burrows Gregory G; Grafe Marjorie R; Vandenbark Arthur A; Hurn Patricia D; Offner Halina
Recombinant T cell receptor ligand treats experimental stroke.
Abulafia-Lapid R; Afentoulis M; Vandenbark A A
Peptide therapy for anti-CD4 autoimmunity in HIV-1 infection: toward the development of an autoimmune animal model.

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All Publications

2009: Vandenbark Arthur A; Huan Jianya; Agotsch Marisa; La Tocha Dorian; Goelz Susan; Offner Halina; Lanker Stefan; Bourdette Dennis
Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis.
Journal of neuroimmunology 2009;215(1-2):125-8.
2009: Subramanian Sandhya; Zhang Bing; Kosaka Yasuharu; Burrows Gregory G; Grafe Marjorie R; Vandenbark Arthur A; Hurn Patricia D; Offner Halina
Recombinant T cell receptor ligand treats experimental stroke.
Stroke; a journal of cerebral circulation 2009;40(7):2539-45.
2009: Abulafia-Lapid R; Afentoulis M; Vandenbark A A
Peptide therapy for anti-CD4 autoimmunity in HIV-1 infection: toward the development of an autoimmune animal model.
Vaccine 2009;27(25-26):3475-80.
2009: Sinha Sushmita; Subramanian Sandhya; Miller Lisa; Proctor Thomas M; Roberts Chris; Burrows Gregory G; Vandenbark Arthur A; Offner Halina
Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single recombinant T-cell receptor ligand.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(12):3816-23.
2009: Wang Chunhe; Dehghani Babak; Li Yuexin; Kaler Laurie J; Vandenbark Arthur A; Offner Halina
Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1.
Immunology 2009;126(3):329-35.
2009: Wang Chunhe; Dehghani Babak; Li Yuexin; Kaler Laurie J; Proctor Thomas; Vandenbark Arthur A; Offner Halina
Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):3294-303.
2009: Offner H; Vandenbark A A; Hurn P D
Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression.
Neuroscience 2009;158(3):1098-111.
2008: Vandenbark Arthur A; Offner Halina
Critical evaluation of regulatory T cells in autoimmunity: are the most potent regulatory specificities being ignored?
Immunology 2008;125(1):1-13.
2008: Wang Chunhe; Dehghani Babak; Magrisso I Jack; Rick Elizabeth A; Bonhomme Edna; Cody David B; Elenich Laura A; Subramanian Sandhya; Murphy Stephanie J; Kelly Martin J; Rosenbaum Jan S; Vandenbark Arthur A; Offner Halina
GPR30 contributes to estrogen-induced thymic atrophy.
Molecular endocrinology (Baltimore, Md.) 2008;22(3):636-48.
2008: Sinha Sushmita; Kaler Laurie J; Proctor Thomas M; Teuscher Cory; Vandenbark Arthur A; Offner Halina
IL-13-mediated gender difference in susceptibility to autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2679-85.
2008: Huan Jianya; Kaler Laurie J; Mooney Jeffery L; Subramanian Sandhya; Hopke Corwyn; Vandenbark Arthur A; Rosloniec Edward F; Burrows Gregory G; Offner Halina
MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1249-57.
2008: Smyk-Pearson Susan; Golden-Mason Lucy; Klarquist Jared; Burton James R; Tester Ian A; Wang Chia C; Culbertson Nicole; Vandenbark Arthur A; Rosen Hugo R
Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection.
The Journal of infectious diseases 2008;197(1):46-57.
2008: Vandenbark Arthur A; Culbertson Nicole E; Bartholomew Richard M; Huan Jianya; Agotsch Marci; LaTocha Dorian; Yadav Vijayshree; Mass Michele; Whitham Ruth; Lovera Jesus; Milano June; Theofan Georgia; Chou Yuan K; Offner Halina; Bourdette Dennis N
Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis.
Immunology 2008;123(1):66-78.
2008: Offner Halina; Sinha Sushmita; Wang Chunhe; Burrows Gregory G; Vandenbark Arthur A
Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis.
Reviews in the neurosciences 2008;19(4-5):327-39.
2008: Vandenbark Arthur A; Abulafia-Lapid Rivka
Autologous T-cell vaccination for multiple sclerosis: a perspective on progress.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2008;22(4):265-73.
2007: Sinha Sushmita; Subramanian Sandhya; Proctor Thomas M; Kaler Laurie J; Grafe Marjorie; Dahan Rony; Huan Jianya; Vandenbark Arthur A; Burrows Gregory G; Offner Halina
A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(46):12531-9.
2007: Hurn Patricia D; Subramanian Sandhya; Parker Susan M; Afentoulis Michael E; Kaler Laurie J; Vandenbark Arthur A; Offner Halina
T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(11):1798-805.
2007: Imam Sarah A; Guyton Mary K; Haque Azizul; Vandenbark Arthur; Tyor William R; Ray Swapan K; Banik Naren L
Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients.
Journal of neuroimmunology 2007;190(1-2):139-45.
2007: Klyushnenkova Elena N; Kouiavskaia Diana V; Kodak James A; Vandenbark Arthur A; Alexander Richard B
Identification of HLA-DRB1*1501-restricted T-cell epitopes from human prostatic acid phosphatase.
The Prostate 2007;67(10):1019-28.
2007: Link Jason M; Rich Cathleen M; Korat Maya; Burrows Gregory G; Offner Halina; Vandenbark Arthur A
Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of experimental encephalomyelitis in DR2 transgenic mice.
Clinical immunology (Orlando, Fla.) 2007;123(1):95-104.
2007: Polanczyk Magdalena J; Hopke Corwyn; Vandenbark Arthur A; Offner Halina
Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1).
International immunology 2007;19(3):337-43.
2006: Fontenot Andrew P; Keizer Timothy S; McCleskey Mark; Mack Douglas G; Meza-Romero Roberto; Huan Jianya; Edwards David M; Chou Yuan K; Vandenbark Arthur A; Scott Brian; Burrows Gregory G
Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3874-83.
2006: Wang Chunhe; Gold Bruce G; Kaler Laurie J; Yu Xiaolin; Afentoulis Michael E; Burrows Gregory G; Vandenbark Arthur A; Bourdette Dennis N; Offner Halina
Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE.
Journal of neurochemistry 2006;98(6):1817-27.
2006: Polanczyk Magdalena J; Hopke Corwyn; Vandenbark Arthur A; Offner Halina
Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway.
Journal of neuroscience research 2006;84(2):370-8.
2006: Wang Chunhe; Chou Yuan K; Rich Cathleen M; Link Jason M; Afentoulis Michael E; van Noort Johannes M; Wawrousek Eric F; Offner Halina; Vandenbark Arthur A
AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic.
Journal of neuroimmunology 2006;176(1-2):51-62.
2006: Adamus Grazyna; Burrows Gregory G; Vandenbark Arthur A; Offner Halina
Treatment of autoimmune anterior uveitis with recombinant TCR ligands.
Investigative ophthalmology & visual science 2006;47(6):2555-61.
2006: Offner Halina; Subramanian Sandhya; Parker Susan M; Wang Chunhe; Afentoulis Michael E; Lewis Anne; Vandenbark Arthur A; Hurn Patricia D
Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6523-31.
2006: Offner Halina; Subramanian Sandhya; Parker Susan M; Afentoulis Michael E; Vandenbark Arthur A; Hurn Patricia D
Experimental stroke induces massive, rapid activation of the peripheral immune system.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(5):654-65.
2006: Fontenot Andrew P; Edwards David M; Chou Yuan K; Mack Douglas G; LaTocha Dorian; Vandenbark Arthur A; Burrows Gregory G
Self-presentation of beryllium by BAL CD4+ T cells: T cell-T cell interactions and their potential role in chronic beryllium disease.
European journal of immunology 2006;36(4):930-9.
2005: Polanczyk Magdalena J; Hopke Corwyn; Huan Jianya; Vandenbark Arthur A; Offner Halina
Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice.
Journal of neuroimmunology 2005;170(1-2):85-92.
2005: Bourdette D N; Edmonds E; Smith C; Bowen J D; Guttmann C R G; Nagy Z P; Simon J; Whitham R; Lovera J; Yadav V; Mass M; Spencer L; Culbertson N; Bartholomew R M; Theofan G; Milano J; Offner H; Vandenbark A A
A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) 2005;11(5):552-61.
2005: Offner Halina; Vandenbark Arthur A
Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS.
International reviews of immunology 2005;24(5-6):447-77.
2005: Offner Halina; Subramanian Sandhya; Wang Chunhe; Afentoulis Michael; Vandenbark Arthur A; Huan Jianya; Burrows Gregory G
Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injury.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):4103-11.
2005: Huan Jianya; Culbertson Nicole; Spencer Leslie; Bartholomew Richard; Burrows Gregory G; Chou Yuan K; Bourdette Dennis; Ziegler Steven F; Offner Halina; Vandenbark Arthur A
Decreased FOXP3 levels in multiple sclerosis patients.
Journal of neuroscience research 2005;81(1):45-52.
2005: Subramanian Sandhya; Tovey Micah; Afentoulis Michael; Krogstad Aric; Vandenbark Arthur A; Offner Halina
Ethinyl estradiol treats collagen-induced arthritis in DBA/1LacJ mice by inhibiting the production of TNF-alpha and IL-1beta.
Clinical immunology (Orlando, Fla.) 2005;115(2):162-72.
2005: Vandenbark Arthur A
TCR peptide vaccination in multiple sclerosis: boosting a deficient natural regulatory network that may involve TCR-specific CD4+CD25+ Treg cells.
Current drug targets. Inflammation and allergy 2005;4(2):217-29.
2005: Klyushnenkova Elena N; Link Jason; Oberle Warren T; Kodak James; Rich Cathleen; Vandenbark Arthur A; Alexander Richard B
Identification of HLA-DRB1*1501-restricted T-cell epitopes from prostate-specific antigen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(8):2853-61.
2005: Chou Yuan K; Edwards David M; Weinberg Andrew D; Vandenbark Arthur A; Kotzin Brian L; Fontenot Andrew P; Burrows Gregory G
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4316-24.
2005: Matejuk Agata; Hopke Corwyn; Vandenbark Arthur A; Hurn Patricia D; Offner Halina
Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2387-95.
2004: Polanczyk Magdalena J; Jones Richard E; Subramanian Sandhya; Afentoulis Michael; Rich Cathleen; Zakroczymski Melissa; Cooke Paul; Vandenbark Arthur A; Offner Halina
T lymphocytes do not directly mediate the protective effect of estrogen on experimental autoimmune encephalomyelitis.
The American journal of pathology 2004;165(6):2069-77.
2004: Zucker Stanley; Crabbe John C; Cooper George; Finkelman Fred; Largman Corey; McCarley Robert W; Rice Louis; Rubin Janet; Richardson Bruce; Seil Frederick; Snider Gordon L; Vandenbark Arthur A
Veterans Administration support for medical research: opinions of the endangered species of physician-scientists.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(13):1481-6.
2004: Finn Thomas P; Jones Richard E; Rich Cathleen; Dahan Rony; Link Jason; David Chella S; Chou Yuan K; Offner Halina; Vandenbark Arthur A
HLA-DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes.
Journal of neuroscience research 2004;78(1):100-14.
2004: Chou Yuan K; Culbertson Nicole; Rich Cathleen; LaTocha Dorian; Buenafe Abigail C; Huan Jianya; Link Jason; Wands J M; Born Willi K; Offner Halina; Bourdette Dennis N; Burrows Gregory G; Vandenbark Arthur A
T-cell hybridoma specific for myelin oligodendrocyte glycoprotein-35-55 peptide produced from HLA-DRB1*1501-transgenic mice.
Journal of neuroscience research 2004;77(5):670-80.
2004: Polanczyk Magdalena J; Carson Bryan D; Subramanian Sandhya; Afentoulis Michael; Vandenbark Arthur A; Ziegler Steven F; Offner Halina
Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2227-30.
2004: Matejuk Agata; Bakke Antony C; Hopke Corwyn; Dwyer Jami; Vandenbark Arthur A; Offner Halina
Estrogen treatment induces a novel population of regulatory cells, which suppresses experimental autoimmune encephalomyelitis.
Journal of neuroscience research 2004;77(1):119-26.
2004: Polanczyk Magdalena; Yellayi Srikanth; Zamora Alex; Subramanian Sandhya; Tovey Micah; Vandenbark Arthur A; Offner Halina; Zachary James F; Fillmore Parley D; Blankenhorn Elizabeth P; Gustafsson Jan-Ake; Teuscher Cory
Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice.
The American journal of pathology 2004;164(6):1915-24.
2004: Rich Cathleen; Link Jason M; Zamora Alex; Jacobsen Helle; Meza-Romero Roberto; Offner Halina; Jones Richard; Burrows Gregory G; Fugger Lars; Vandenbark Arthur A
Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice.
European journal of immunology 2004;34(5):1251-61.
2004: Buenafe Abigail C; Tsaknaridis Laura; Spencer Leslie; Hicks Kevin S; McMahan Rachel H; Watson Lisa; Culbertson Nicole E; Latocha Dorian; Wegmann Keith; Finn Tom; Bartholomew Richard; Burrows Gregory G; Whitham Ruth; Bourdette Dennis N; Jones Richard E; Offner Halina; Chou Yuan K; Vandenbark Arthur A
Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants.
Journal of neuroscience research 2004;76(1):129-40.
2004: Huan Jianya; Subramanian Sandhya; Jones Richard; Rich Cathleen; Link Jason; Mooney Jeff; Bourdette Dennis N; Vandenbark Arthur A; Burrows Gregory G; Offner Halina
Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4556-66.
2004: Chou Yuan K; Burrows Gregory G; LaTocha Dorian; Wang Chunhe; Subramanian Sandhya; Bourdette Dennis N; Vandenbark Arthur A
CD4 T-cell epitopes of human alpha B-crystallin.
Journal of neuroscience research 2004;75(4):516-23.
2004: Matejuk Agata; Dwyer Jami; Hopke Corwyn; Vandenbark Arthur A; Offner Halina
Opposing roles for TGF-beta1 and TGF-beta3 isoforms in experimental autoimmune encephalomyelitis.
Cytokine 2004;25(2):45-51.
2003: Tsaknaridis Laura; Spencer Leslie; Culbertson Nicole; Hicks Kevin; LaTocha Dorian; Chou Yuan K; Whitham Ruth H; Bakke Antony; Jones Richard E; Offner Halina; Bourdette Dennis N; Vandenbark Arthur A
Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity.
Journal of neuroscience research 2003;74(2):296-308.
2003: Polanczyk Magdalena; Zamora Alex; Subramanian Sandhya; Matejuk Agata; Hess David L; Blankenhorn Elizabeth P; Teuscher Cory; Vandenbark Arthur A; Offner Halina
The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha.
The American journal of pathology 2003;163(4):1599-605.
2003: Matejuk Agata; Hopke Corwyn; Dwyer Jami; Subramanian Sandhya; Jones Richard E; Bourdette Dennis N; Vandenbark Arthur A; Offner Halina
CNS gene expression pattern associated with spontaneous experimental autoimmune encephalomyelitis.
Journal of neuroscience research 2003;73(5):667-78.
2003: Wang Chunhe; Mooney Jeffery L; Meza-Romero Roberto; Chou Yuan K; Huan Jianya; Vandenbark Arthur A; Offner Halina; Burrows Gregory G
Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1934-40.
2003: Vandenbark Arthur A; Rich Cathleen; Mooney Jeff; Zamora Alex; Wang Chunhe; Huan Jianya; Fugger Lars; Offner Halina; Jones Richard; Burrows Gregory G
Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):127-33.
2003: Ito Atsushi; Matejuk Agata; Hopke Corwyn; Drought Heather; Dwyer Jami; Zamora Alex; Subramanian Sandhya; Vandenbark Arthur A; Offner Halina
Transfer of severe experimental autoimmune encephalomyelitis by IL-12- and IL-18-potentiated T cells is estrogen sensitive.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4802-9.
2003: Jones Richard E; Bourdette Dennis; Moes Nicole; Vandenbark Arthur; Zamora Alex; Offner Halina
Epitope spreading is not required for relapses in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1690-8.
2003: Subramanian Sandhya; Matejuk Agata; Zamora Alex; Vandenbark Arthur A; Offner Halina
Oral feeding with ethinyl estradiol suppresses and treats experimental autoimmune encephalomyelitis in SJL mice and inhibits the recruitment of inflammatory cells into the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1548-55.
2003: Matejuk Agata; Buenafe Abigail C; Dwyer Jami; Ito Atsushi; Silverman Marc; Zamora Alex; Subramanian Sandhya; Vandenbark Arthur A; Offner Halina
Endogenous CD4+BV8S2- T cells from TG BV8S2+ donors confer complete protection against spontaneous experimental encephalomyelitis (Sp-EAE) in TCR transgenic, RAG-/- mice.
Journal of neuroscience research 2003;71(1):89-103.
2003: Matejuk Agata; Dwyer Jami; Hopke Corwyn; Vandenbark Arthur A; Offner Halina
17Beta-estradiol treatment profoundly down-regulates gene expression in spinal cord tissue in mice protected from experimental autoimmune encephalomyelitis.
Archivum immunologiae et therapiae experimentalis 2003;51(3):185-93.
2002: Liu Hong Yan; Buenafe Abigail C; Matejuk Agata; Ito Atsushi; Zamora Alex; Dwyer Jami; Vandenbark Arthur A; Offner Halina
Estrogen inhibition of EAE involves effects on dendritic cell function.
Journal of neuroscience research 2002;70(2):238-48.
2002: Offner Halina; Zamora Alex; Drought Heather; Matejuk Agata; Auci Dominick L; Morgan Elizabeth E; Vandenbark Arthur A; Reading Christopher L
A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing-remitting EAE.
Journal of neuroimmunology 2002;130(1-2):128-39.
2002: Matejuk Agata; Dwyer Jami; Ito Atsushi; Bruender Zachary; Vandenbark Arthur A; Offner Halina
Effects of cytokine deficiency on chemokine expression in CNS of mice with EAE.
Journal of neuroscience research 2002;67(5):680-8.
2002: Ito Atsushi; Buenafe Abigail C; Matejuk Agata; Zamora Alex; Silverman Marc; Dwyer Jami; Vandenbark Arthur A; Offner Halina
Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis.
Clinical immunology (Orlando, Fla.) 2002;102(3):275-82.
2002: Zamora Alex; Matejuk Agata; Silverman Marc; Vandenbark Arthur A; Offner Halina
Inhibitory effects of incomplete Freund's adjuvant on experimental autoimmune encephalomyelitis.
Autoimmunity 2002;35(1):21-8.
2002: Matejuk Agata; Dwyer Jami; Zamora Alex; Vandenbark Arthur A; Offner Halina
Evaluation of the effects of 17beta-estradiol (17beta-e2) on gene expression in experimental autoimmune encephalomyelitis using DNA microarray.
Endocrinology 2002;143(1):313-9.
2001: Vandenbark A A; Finn T; Barnes D; Culbertson N; Chou Y K; Hicks K; Bakke A; Mass M; Whitham R; Offner H; Bourdette D
Diminished frequency of interleukin-10-secreting, T-cell receptor peptide-reactive T cells in multiple sclerosis patients might allow expansion of activated memory T cells bearing the cognate BV gene.
Journal of neuroscience research 2001;66(2):171-6.
2001: Burrows G G; Chou Y K; Wang C; Chang J W; Finn T P; Culbertson N E; Kim J; Bourdette D N; Lewinsohn D A; Lewinsohn D M; Ikeda M; Yoshioka T; Allen C N; Offner H; Vandenbark A A
Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4386-95.
2001: Matejuk A; Adlard K; Zamora A; Silverman M; Vandenbark A A; Offner H
17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis.
Journal of neuroscience research 2001;65(6):529-42.
2001: Vandenbark A A; Morgan E; Bartholomew R; Bourdette D; Whitham R; Carlo D; Gold D; Hashim G; Offner H
TCR peptide therapy in human autoimmune diseases.
Neurochemical research 2001;26(6):713-30.
2001: Bebo B F; Fyfe-Johnson A; Adlard K; Beam A G; Vandenbark A A; Offner H
Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):2080-9.
2001: Subramanian S; Bourdette D N; Corless C; Vandenbark A A; Offner H; Jones R E
T lymphocytes promote the development of bone marrow-derived APC in the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):370-6.
2001: Buenafe A C; Tsu R C; McMahan R; Bebo B F; Vandenbark A A; Offner H
Rat RT1.B-transfected fibroblast lines process and present myelin antigens and activate T cells to induce experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2001;112(1-2):106-14.
2000: Burrows G G; Adlard K L; Bebo B F; Chang J W; Tenditnyy K; Vandenbark A A; Offner H
Regulation of encephalitogenic T cells with recombinant TCR ligands.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6366-71.
2000: Offner H; Adlard K; Zamora A; Vandenbark A A
Estrogen potentiates treatment with T-cell receptor protein of female mice with experimental encephalomyelitis.
The Journal of clinical investigation 2000;105(10):1465-72.
2000: Bebo B F; Schuster J C; Adlard K; Vandenbark A A; Offner H
Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis.
Cytokine 2000;12(4):324-31.
2000: Matejuk A; Vandenbark A A; Burrows G G; Bebo B F; Offner H
Reduced chemokine and chemokine receptor expression in spinal cords of TCR BV8S2 transgenic mice protected against experimental autoimmune encephalomyelitis with BV8S2 protein.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3924-31.
2000: Vandenbark A A; Barnes D; Finn T; Bourdette D N; Whitham R; Robey I; Kaleeba J; Bebo B F; Miller S D; Offner H; Chou Y K
Differential susceptibility of human T(h)1 versus T(h) 2 cells to induction of anergy and apoptosis by ECDI/antigen-coupled antigen-presenting cells.
International immunology 2000;12(1):57-66.
2000: Vandenbark A A; Culbertson N; Finn T; Barnes D; Buenafe A; Burrows G G; Law S; Chou Y K; Offner H
Human TCR as antigen: homologies and potentially cross-reactive HLA-DR2-restricted epitopes within the AV and BV CDR2 loops.
Critical reviews in immunology 2000;20(1):57-83.
1999: Burrows G G; Chang J W; Bächinger H P; Bourdette D N; Offner H; Vandenbark A A
Design, engineering and production of functional single-chain T cell receptor ligands.
Protein engineering 1999;12(9):771-8.
1999: Chou Y K; Bourdette D N; Barnes D; Finn T P; Murray S; Unsicker L; Robey I; Whitham R H; Buenafe A C; Allegretta M; Offner H; Vandenbark A A
IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R alpha and gamma chains.
Journal of neuroimmunology 1999;96(1):101-11.
1999: Bebo B F; Adlard K; Schuster J C; Unsicker L; Vandenbark A A; Offner H
Gender differences in protection from EAE induced by oral tolerance with a peptide analogue of MBP-Ac1-11.
Journal of neuroscience research 1999;55(4):432-40.
1999: Bebo B F; Schuster J C; Vandenbark A A; Offner H
Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):35-40.
1999: Adlard K; Tsaknardis L; Beam A; Bebo B F; Vandenbark A A; Offner H
Immunoregulation of encephalitogenic MBP-NAc1-11-reactive T cells by CD4+ TCR-specific T cells involves IL-4, IL-10 and IFN-gamma.
Autoimmunity 1999;31(4):237-48.
1999: Offner H; Vandenbark A A
T cell receptor V genes in multiple sclerosis: increased use of TCRAV8 and TCRBV5 in MBP-specific clones.
International reviews of immunology 1999;18(1-2):9-36.
1999: Offner H; Jacobs R; Bebo B F; Vandenbark A A
Treatments targeting the T cell receptor (TCR): effects of TCR peptide-specific T cells on activation, migration, and encephalitogenicity of myelin basic protein-specific T cells.
Springer seminars in immunopathology 1999;21(1):77-90.
1998: Burrows G G; Bebo B F; Adlard K L; Vandenbark A A; Offner H
Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5987-96.
1998: Chou Y K; Robey I; Woody C N; Li W; Offner H; Vandenbark A A; Davey M P
Induction of T cell anergy by high concentrations of immunodominant native peptide is accompanied by IL-10 production and a block in JNK activity.
Cellular immunology 1998;188(2):125-36.
1998: Offner H; Adlard K; Bebo B F; Schuster J; Burrows G G; Buenafe A C; Vandenbark A A
Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2178-86.
1998: Buenafe A C; Offner H; Machnicki M; Elerding H; Adlard K; Jacobs R; Vandenbark A A; Adamus G
EAE TCR motifs and antigen recognition in myelin basic protein-induced anterior uveitis in Lewis rats.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):2052-9.
1998: Bourdette D N; Chou Y K; Whitham R H; Buckner J; Kwon H J; Nepom G T; Buenafe A; Cooper S A; Allegretta M; Hashim G A; Offner H; Vandenbark A A
Immunity to T cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity-determining region 2 peptides from disease-associated T cell receptor BV genes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):1034-44.
1998: Siklodi B; Jacobs R; Vandenbark A A; Offner H
Neonatal exposure of TCR BV8S2 transgenic mice to recombinant TCR BV8S2 results in reduced T cell proliferation and elevated antibody response to BV8S2, and increased severity of EAE.
Journal of neuroscience research 1998;52(6):750-6.
1998: Bebo B F; Schuster J C; Vandenbark A A; Offner H
Gender differences in experimental autoimmune encephalomyelitis develop during the induction of the immune response to encephalitogenic peptides.
Journal of neuroscience research 1998;52(4):420-6.
1998: Bebo B F; Zelinka-Vincent E; Adamus G; Amundson D; Vandenbark A A; Offner H
Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 1998;84(2):122-30.
1998: Kaleeba J A; Offner H; Vandenbark A A; Lublinski A; Weinberg A D
The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells.
International immunology 1998;10(4):453-61.
1998: Vandenbark A A; Chou Y K; Whitham R; Bourdette D N; Offner H
Effects of vaccination with T cell receptor peptides: epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide.
Immunology and cell biology 1998;76(1):83-90.
1998: Ariail K S; Bebo B F; Adlard K; Robey I; Burrows G; Newman M J; Todd C W; Vandenbark A A; Offner H
Novel adjuvants for induction of T-cell and antibody responses to encephalitogenic and regulatory determinants in Lewis rats.
Vaccine 1998;16(1):99-108.
1997: Burrows G G; Ariail K; Celnik B; Gambee J E; Offner H; Vandenbark A A
Multiple class I motifs revealed by sequencing naturally processed peptides eluted from rat T cell MHC molecules.
Journal of neuroscience research 1997;49(1):107-16.
1997: Buenafe A C; Tsu R C; Bebo B; Bakke A C; Vandenbark A A; Offner H
A TCR V alpha CDR3-specific motif associated with Lewis rat autoimmune encephalomyelitis and basic protein-specific T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5472-83.
1997: Buenafe A C; Tsu R C; Bebo B; Vandenbark A A; Offner H
Myelin basic protein-specific and TCR V beta 8.2-specific T-cell lines from TCR V beta 8.2 transgenic mice utilize the same V alpha and V beta genes: specificity associated with the V alpha CDR3-J alpha region.
Journal of neuroscience research 1997;47(5):489-99.
1996: Vandenbark A A; Chou Y K; Whitham R; Mass M; Buenafe A; Liefeld D; Kavanagh D; Cooper S; Hashim G A; Offner H
Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial.
Nature medicine 1996;2(10):1109-15.
1996: Chou Y K; Weinberg A D; Buenafe A; Bourdette D N; Whitham R; Kaleeba J A; Robey I F; Kavanagh D G; Offner H; Vandenbark A A
MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR V beta CDR2 peptides: comparison with myelin basic protein-specific T cells.
Journal of neuroscience research 1996;45(6):838-51.
1996: Burrows G G; Ariail K; Celnik B; Gambee J E; Bebo B F; Offner H; Vandenbark A A
Variation in H-2K(k) peptide motif revealed by sequencing naturally processed peptides from T-cell hybridoma class I molecules.
Journal of neuroscience research 1996;45(6):803-11.
1996: Bebo B F; Vandenbark A A; Offner H
Male SJL mice do not relapse after induction of EAE with PLP 139-151.
Journal of neuroscience research 1996;45(6):680-9.
1996: Vainiene M; Burrows G G; Ariail K; Robey I; Vandenbark A A; Offner H
Neonatal injection of Lewis rats with recombinant V beta 8.2 induces T cell but not B cell tolerance and increased severity of experimental autoimmune encephalomyelitis.
Journal of neuroscience research 1996;45(4):475-86.
1996: Vandenbark A A; Vainiene M; Ariail K; Miller S D; Offner H
Prevention and treatment of relapsing autoimmune encephalomyelitis with myelin peptide-coupled splenocytes.
Journal of neuroscience research 1996;45(4):430-8.
1996: Whitham R H; Wingett D; Wineman J; Mass M; Wegmann K; Vandenbark A; Offner H
Treatment of relapsing autoimmune encephalomyelitis with T cell receptor V beta-specific antibodies when proteolipid protein is the autoantigen.
Journal of neuroscience research 1996;45(2):104-16.
1996: Buenafe A C; Weinberg A D; Culbertson N E; Vandenbark A A; Offner H
V beta CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of Lewis rats with EAE.
Journal of neuroscience research 1996;44(6):562-7.
1996: Vandenbark A A; Hashim G A; Offner H
T cell receptor peptides in treatment of autoimmune disease: rationale and potential.
Journal of neuroscience research 1996;43(4):391-402.
1996: Weinberg A D; Bourdette D N; Sullivan T J; Lemon M; Wallin J J; Maziarz R; Davey M; Palida F; Godfrey W; Engleman E; Fulton R J; Offner H; Vandenbark A A
Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis.
Nature medicine 1996;2(2):183-9.
1996: Weinberg A D; Lemon M; Jones A J; Vainiene M; Celnik B; Buenafe A C; Culbertson N; Bakke A; Vandenbark A A; Offner H
OX-40 antibody enhances for autoantigen specific V beta 8.2+ T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis.
Journal of neuroscience research 1996;43(1):42-9.
1996: Vainiene M; Celnik B; Vandenbark A A; Hashim G A; Offner H
Natural immunodominant and experimental autoimmune encephalomyelitis-protective determinants within the Lewis rat V beta 8.2 sequence include CDR2 and framework 3 idiotopes.
Journal of neuroscience research 1996;43(2):137-45.
1995: Morrison W J; Kennedy N J; Offner H; Vandenbark A A
Antigen-specific T-cell activations distinguished by in vivo anti-CD4 antibody treatment.
International journal of immunopharmacology 1995;17(12):1017-25.
1995: Vandenbark A A; Celnik B; Vainiene M; Miller S D; Offner H
Myelin antigen-coupled splenocytes suppress experimental autoimmune encephalomyelitis in Lewis rats through a partially reversible anergy mechanism.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5861-7.
1995: Buenafe A C; Vainiene M; Celnik B; Vandenbark A A; Offner H
Analysis of V beta 8.2 CDR3 sequences from spinal cord T cells of Lewis rats vaccinated or treated with TCR V beta 8.2-39-59 peptide.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1556-64.
1995: Xian C J; Simmons R D; Willenborg D O; Vandenbark A A; Hashim G A; Carnegie P R
Studies on T-cell receptors involved in experimental autoimmune encephalomyelitis using the complementary peptide recognition approach.
Journal of neuroscience research 1995;41(5):620-7.
1995: Morrison W J; Kennedy N J; Offner H; Vandenbark A A
Effects of anti-CD4 antibody: enhancement of lymph node PPD-memory T cell response.
Cellular immunology 1995;163(1):106-12.
1995: Vandenbark A A
Autoimmune diseases: promising emerging therapies.
The Journal of investigative dermatology 1995;104(5 Suppl):10S-12S.
1995: Jones R E; Chou Y; Young A; Mass M; Vandenbark A; Offner H; Bourdette D
T cells with encephalitogenic potential from multiple sclerosis patients and Lewis rats fail to induce disease in SCID mice following intracisternal injection.
Journal of neuroimmunology 1995;56(2):119-26.
1995: Offner H; Malotky M K; Pope L; Vainiene M; Celnik B; Miller S D; Vandenbark A A
Increased severity of experimental autoimmune encephalomyelitis in rats tolerized as adults but not neonatally to a protective TCR V beta 8 CDR2 idiotope.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):928-35.
1995: Vandenbark A A; Hashim G A; Offner H
Idiotypic regulation directed at T-cell receptor determinants.
Chemical immunology 1995;60():100-25.
1994: Offner H; Vainiene M; Celnik B; Weinberg A D; Buenafe A; Vandenbark A A
Coculture of TCR peptide-specific T cells with basic protein-specific T cells inhibits proliferation, IL-3 mRNA, and transfer of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):4988-96.
1994: Buenafe A C; Vainiene M; Celnik B; Vandenbark A A; Offner H
Analysis of V beta 8-CDR3 sequences derived from central nervous system of Lewis rats with experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):386-94.
1994: Vandenbark A A; Vainiene M; Celnik B; Hashim G A; Buenafe A; Offner H
Definition of encephalitogenic and immunodominant epitopes of guinea pig myelin basic protein (Gp-BP) in Lewis rats tolerized neonatally with Gp-BP or Gp-BP peptides.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):852-61.
1994: Offner H; Hashim G A; Vandenbark A A
Immunity to T cell receptor peptides: theory and applications.
Regulatory peptides 1994;51(2):77-90.
1994: Morrison W J; Offner H; Vandenbark A A
Understanding the CD4 molecule: surface expression and function.
Journal of neuroscience research 1994;38(1):1-5.
1994: Weinberg A D; Wallin J J; Jones R E; Sullivan T J; Bourdette D N; Vandenbark A A; Offner H
Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4712-21.
1994: Chou Y K; Morrison W J; Weinberg A D; Dedrick R; Whitham R; Bourdette D N; Hashim G; Offner H; Vandenbark A A
Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2520-9.
1994: Bourdette D N; Whitham R H; Chou Y K; Morrison W J; Atherton J; Kenny C; Liefeld D; Hashim G A; Offner H; Vandenbark A A
Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2510-9.
1994: Morrison W J; Offner H; Vandenbark A A
Enhanced T-helper cell function following CD4 modulation.
Cellular immunology 1994;153(2):392-400.
1994: Weinberg A D; Celnik B; Vainiene M; Buenafe A C; Vandenbark A A; Offner H
The effect of TCR V beta 8 peptide protection and therapy on T cell populations isolated from the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 1994;49(1-2):161-70.
1994: Vandenbark A A; Offner H; Hashim G A
Modulation of EAE by vaccination with T cell receptor peptides: V beta 8 T cell receptor peptide-specific CD4+ lymphocytes lack direct immunoregulatory activity.
Journal of neuroimmunology 1994;49(1-2):221; author reply 222.
1994: Chou Y K; Jones R E; Bourdette D; Whitham R; Hashim G; Atherton J; Offner H; Vandenbark A A
Human myelin basic protein (MBP) epitopes recognized by mouse MBP-selected T cell lines from multiple sclerosis patients.
Journal of neuroimmunology 1994;49(1-2):45-50.
1993: Vandenbark A A; Bourdette D N; Whitham R; Chou Y K; Hashim G A; Offner H
Episodic changes in T-cell frequencies to myelin basic protein in patients with multiple sclerosis.
Neurology 1993;43(11):2416-7.
1993: Weinberg A D; Wyrick G; Celnik B; Vainiene M; Bakke A; Offner H; Vandenbark A A
Lymphokine mRNA expression in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis is associated with a host recruited CD45R hi/CD4+ population during recovery.
Journal of neuroimmunology 1993;48(1):105-17.
1993: Offner H; Buenafe A C; Vainiene M; Celnik B; Weinberg A D; Gold D P; Hashim G; Vandenbark A A
Where, when, and how to detect biased expression of disease-relevant V beta genes in rats with experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):506-17.
1993: Whitham R H; Kotzin B L; Buenafe A C; Weinberg A D; Jones R E; Hashim G A; Hoy C M; Vandenbark A A; Offner H
Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides.
Journal of neuroscience research 1993;35(2):115-28.
1993: Jones R E; Bourdette D N; Whitham R H; Offner H; Vandenbark A A
Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4620-9.
1993: Satyanarayana K; Chou Y K; Bourdette D; Whitham R; Hashim G A; Offner H; Vandenbark A A
Epitope specificity and V gene expression of cerebrospinal fluid T cells specific for intact versus cryptic epitopes of myelin basic protein.
Journal of neuroimmunology 1993;44(1):57-67.
1993: Vandenbark A A; Bourdette D N; Whitham R; Chou Y K; Hashim G A; Offner H
T-cell receptor peptide therapy in EAE and MS.
Clinical and experimental rheumatology 1993;11 Suppl 8():S51-3.
1993: Morrison W J; Young K; Offner H; Vandenbark A A
Ganglioside (GM1) distinguishes the effects of CD4 on signal transduction through the TCR/CD3 complex in human lymphocytes.
Cellular & molecular biology research 1993;39(2):159-65.
1993: Vandenbark A A; Hashim G; Offner H
TCR peptide therapy in autoimmune diseases.
International reviews of immunology 1993;9(4):251-76.
1992: Hashim G A; Offner H; Wang R Y; Shukla K; Carvalho E; Morrison W J; Vandenbark A A
Spontaneous development of protective anti-T cell receptor autoimmunity targeted against a natural EAE-regulatory idiotope located within the 39-59 region of the TCR-V beta 8.2 chain.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2803-9.
1992: Vandenbark A A; Vainiene M; Celnik B; Hashim G; Offner H
TCR peptide therapy decreases the frequency of encephalitogenic T cells in the periphery and the central nervous system.
Journal of neuroimmunology 1992;39(3):251-60.
1992: Chou Y K; Bourdette D N; Offner H; Whitham R; Wang R Y; Hashim G A; Vandenbark A A
Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis.
Journal of neuroimmunology 1992;38(1-2):105-13.
1992: Vandenbark A A; Chou Y K; Bourdette D N; Whitham R; Hashim G A; Offner H
T cell receptor peptide therapy for autoimmune disease.
Journal of autoimmunity 1992;5 Suppl A():83-92.
1992: Jones R E; Bourdette D; Offner H; Vandenbark A A
The synthetic 87-99 peptide of myelin basic protein is encephalitogenic in Buffalo rats.
Journal of neuroimmunology 1992;37(3):203-12.
1992: Weinberg A D; Whitham R; Swain S L; Morrison W J; Wyrick G; Hoy C; Vandenbark A A; Offner H
Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2109-17.
1992: Vainiene M; Gold D P; Celnik B; Hashim G A; Vandenbark A A; Offner H
Common sequence on distinct V beta genes defines a protective idiotope in experimental encephalomyelitis.
Journal of neuroscience research 1992;31(3):413-20.
1992: Gold D P; Vainiene M; Celnik B; Wiley S; Gibbs C; Hashim G A; Vandenbark A A; Offner H
Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. II. Biased T cell receptor V beta expression predominates in spinal cord infiltrating T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1712-7.
1992: Offner H; Vainiene M; Gold D P; Celnik B; Wang R; Hashim G A; Vandenbark A A
Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. I. T cell receptor peptide regulation of T cell clones expressing cross-reactive V beta genes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1706-11.
1992: Chou Y K; Henderikx P; Jones R E; Kotzin B; Hashim G A; Offner H; Vandenbark A A
Human CD8+ T cell clone regulates autologous CD4+ myelin basic protein specific T cells.
Autoimmunity 1992;14(2):111-9.
1991: Gold D P; Offner H; Sun D; Wiley S; Vandenbark A A; Wilson D B
Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3.
The Journal of experimental medicine 1991;174(6):1467-76.
1991: Whitham R H; Jones R E; Hashim G A; Hoy C M; Wang R Y; Vandenbark A A; Offner H
Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3803-8.
1991: Bourdette D N; Vainiene M; Morrison W; Jones R; Turner M J; Hashim G A; Vandenbark A A; Offner H
Myelin basic protein specific T cell lines and clones derived from the CNS of rats with EAE only recognize encephalitogenic epitopes.
Journal of neuroscience research 1991;30(2):308-15.
1991: Kotzin B L; Karuturi S; Chou Y K; Lafferty J; Forrester J M; Better M; Nedwin G E; Offner H; Vandenbark A A
Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(20):9161-5.
1991: Morrison W J; Offner H; Vandenbark A A
Ganglioside (GM1)-treated T cells shed CD4.
Immunopharmacology 1991;22(2):77-84.
1991: Vainiene M; Offner H; Morrison W J; Wilkinson M; Vandenbark A A
Clonal diversity of basic protein specific T cells in Lewis rats recovered from experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 1991;33(3):207-16.
1991: Offner H; Vainiene M; Gold D P; Morrison W J; Wang R Y; Hashim G A; Vandenbark A A
Protection against experimental encephalomyelitis. Idiotypic autoregulation induced by a nonencephalitogenic T cell clone expressing a cross-reactive T cell receptor V gene.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(12):4165-72.
1991: Chou Y K; Henderikx P; Vainiene M; Whitham R; Bourdette D; Chou C H; Hashim G; Offner H; Vandenbark A A
Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein.
Journal of neuroscience research 1991;28(2):280-90.
1991: Hashim G A; Vandenbark A A; Offner H
Antibodies against T-cell receptor peptide arrest autoimmune rejection of normal central nervous system myelin.
Transplantation proceedings 1991;23(1 Pt 1):83-5.
1991: Offner H; Hashim G A; Vandenbark A A
T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis.
Science (New York, N.Y.) 1991;251(4992):430-2.
1991: Hashim G; Vandenbark A A; Gold D P; Diamanduros T; Offner H
T cell lines specific for an immunodominant epitope of human basic protein define an encephalitogenic determinant for experimental autoimmune encephalomyelitis-resistant LOU/M rats.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):515-20.
1991: Whitham R H; Bourdette D N; Hashim G A; Herndon R M; Ilg R C; Vandenbark A A; Offner H
Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(1):101-7.
1991: Vandenbark A A; Chou Y K; Hashim G; Offner H
Immunization with T cell receptor peptides.
British journal of rheumatology 1991;30 Suppl 2():20-3.
1990: Jones R E; Bourdette D N; Offner H; Vandenbark A A
Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in Buffalo rats.
Journal of neuroimmunology 1990;30(1):61-9.
1990: Morrison W J; Offner H; Vandenbark A A
Transmembrane signalling associated with ganglioside-induced CD4 modulation.
Immunopharmacology 1990;20(2):135-41.
1990: Offner H; Celnik B; Bringman T S; Casentini-Borocz D; Nedwin G E; Vandenbark A A
Recombinant human beta-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 1990;28(2):177-84.
1990: Hashim G A; Vandenbark A A; Galang A B; Diamanduros T; Carvalho E; Srinivasan J; Jones R; Vainiene M; Morrison W J; Offner H
Antibodies specific for VB8 receptor peptide suppress experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(12):4621-7.
1990: Whitham R H; Vandenbark A A; Bourdette D N; Chou Y K; Offner H
Suppressor cell regulation of encephalitogenic T cell lines: generation of suppressor macrophages with cyclosporin A and myelin basic protein.
Cellular immunology 1990;126(2):290-303.
1990: Bourdette D N; Turner M J; Vandenbark A A; Offner H
Characterization of basic protein-specific T cell lines selected from Lewis rats with relapsing experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 1990;26(1):81-5.
1990: Vandenbark A A; Hashim G; Offner H
Myelin basic protein, MHC restriction molecules and T cell repertoire.
Progress in clinical and biological research 1990;336():93-108.
1989: Vandenbark A A; Hashim G A; Celnik B; Galang A; Li X B; Heber-Katz E; Offner H
Determinants of human myelin basic protein that induce encephalitogenic T cells in Lewis rats.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3512-6.
1989: Hashim G A; Galang A B; Srinivasan J V; Carvalho E F; Offner H; Vandenbark A A; Cleveland W L; Day E D
Defective T helper cell epitope responsible for the failure of region 69-84 of the human myelin basic protein to induce experimental allergic encephalomyelitis in the Lewis rat.
Journal of neuroscience research 1989;24(2):222-30.
1989: Vandenbark A A; Hashim G; Offner H
Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis.
Nature 1989;341(6242):541-4.
1989: Jones R E; Offner H; Dietsch G; Hinrichs D; Vandenbark A A
PHA activation of encephalitogenic T cells: in vitro line selection overcomes splenic suppression.
Cellular immunology 1989;123(1):60-9.
1989: Zhang J W; Lambrechts J; Heyligen H; Vandenbark A A; Raus J C
Human B cell lines secreting IgM antibody specific for myelin basic protein.
Journal of neuroimmunology 1989;24(1-2):9-16.
1989: Zhang J W; Vandenbark A A; Jacobs M P; Offner H; Raus J C
Murine monoclonal anti-myelin basic protein (MBP) antibodies inhibit proliferation and cytotoxicity of MBP-specific human T cell clones.
Journal of neuroimmunology 1989;24(1-2):87-94.
1989: Offner H; Hashim G A; Celnik B; Galang A; Li X B; Burns F R; Shen N; Heber-Katz E; Vandenbark A A
T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.
The Journal of experimental medicine 1989;170(2):355-67.
1989: Zhang J W; Lambrechts J; Heyligen H; Vandenbark A A; Raus J
Human B cell lines secreting IgM antibody specific for myelin basic protein.
Journal of neuroimmunology 1989;23(3):249-56.
1989: Chou Y K; Vainiene M; Whitham R; Bourdette D; Chou C H; Hashim G; Offner H; Vandenbark A A
Response of human T lymphocyte lines to myelin basic protein: association of dominant epitopes with HLA class II restriction molecules.
Journal of neuroscience research 1989;23(2):207-16.
1989: Zhang J W; Weber W E; Borst J; Vandenbark A A; Raus J C
A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):3917-22.
1989: Vandenbark A A; Chou Y K; Bourdette D; Whitham R; Chilgren J; Chou C H; Konat G; Hashim G; Vainiene M; Offner H
Human T lymphocyte response to myelin basic protein: selection of T lymphocyte lines from MBP-responsive donors.
Journal of neuroscience research 1989;23(1):21-30.
1989: Bourdette D N; Vandenbark A A; Hashim G; Whitham R H; Offner H
T cell lines selected with synthetic peptides are highly encephalitogenic in SJL/J mice.
Journal of neuroimmunology 1989;22(3):255-60.
1989: Chou Y K; Vandenbark A A; Jones R E; Hashim G; Offner H
Selection of encephalitogenic rat T-lymphocyte clones recognizing an immunodominant epitope on myelin basic protein.
Journal of neuroscience research 1989;22(2):181-7.
1989: Offner H; Jones R; Celnik B; Vandenbark A A
Lymphocyte vaccination against experimental autoimmune encephalomyelitis: evaluation of vaccination protocols.
Journal of neuroimmunology 1989;21(1):13-22.
1989: Burns F R; Li X B; Shen N; Offner H; Chou Y K; Vandenbark A A; Heber-Katz E
Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.
The Journal of experimental medicine 1989;169(1):27-39.
1989: Morrison W J; Offner H; Vandenbark A A
Specific ganglioside binding to receptor sites on T lymphocytes that couple to ganglioside-induced decrease of CD4 expression.
Life sciences 1989;45(14):1219-26.
1988: Offner H; Hashim G A; Chou Y K; Celnik B; Jones R; Vandenbark A A
Encephalitogenic T cell clones with variant receptor specificity.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3828-32.
1988: Happ M P; Kiraly A S; Offner H; Vandenbark A; Heber-Katz E
The autoreactive T cell population in experimental allergic encephalomyelitis: T cell receptor beta-chain rearrangements.
Journal of neuroimmunology 1988;19(3):191-204.
1988: Bourdette D N; Vandenbark A A; Meshul C; Whitham R; Offner H
Basic protein-specific T-cell lines that induce experimental autoimmune encephalomyelitis in SJL/J mice: comparison with Lewis rat lines.
Cellular immunology 1988;112(2):351-63.
1988: Whitham R H; Bourdette D N; Offner H; Meshul C K; Vandenbark A A
Suppressor cell regulation of chronic relapsing experimental allergic encephalomyelitis.
Annals of the New York Academy of Sciences 1988;540():537-9.
1988: Offner H; Jones R; Vandenbark A A
Attenuated T-lymphocyte lines as vaccinating agents against experimental autoimmune encephalomyelitis.
Annals of the New York Academy of Sciences 1988;540():540-2.
1988: Vandenbark A A; Hashim G; Offner H
Response of rat encephalitogenic T cells to synthetic peptides of guinea pig myelin basic protein.
Annals of the New York Academy of Sciences 1988;540():337-9.
1987: Offner H; Thieme T; Vandenbark A A
Gangliosides induce selective modulation of CD4 from helper T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3295-305.
1987: Vandenbark A A; Teal P; Offner H
Activation of an encephalitogenic T lymphocyte line with a cellfree supernatant containing basic protein and I region gene products.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(2):452-9.
1987: Offner H; Hashim G; Vandenbark A A
Response of rat encephalitogenic T lymphocyte lines to synthetic peptides of myelin basic protein.
Journal of neuroscience research 1987;17(4):344-8.
1986: Offner H; Brostoff S W; Vandenbark A A
Antibodies against I-A and I-E determinants inhibit the activation and function of encephalitogenic T-lymphocyte lines.
Cellular immunology 1986;100(2):364-73.
1986: Ashorn R G; Vandenbark A A; Acott K M; Krohn K J
Dialysable leukocyte extracts (transfer factor) augment nonspecifically keyhole limpet haemocyanin and horseshoe crab haemocyanin skin reactivity in unimmunized human recipients.
Scandinavian journal of immunology 1986;23(2):161-7.
1986: Beraud E; Reshef T; Vandenbark A A; Offner H; Friz R; Chou C H; Bernard D; Cohen I R
Experimental autoimmune encephalomyelitis mediated by T lymphocyte lines: genotype of antigen-presenting cells influences immunodominant epitope of basic protein.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(2):511-5.
1986: Vandenbark A A; Nilaver G; Konat G; Teal P; Offner H
Chronic neurologic dysfunction and demyelination induced in Lewis rats by repeated injections of encephalitogenic T-lymphocyte lines.
Journal of neuroscience research 1986;16(4):643-56.
1985: Offner H; Vandenbark A A
Gangliosides inhibit phenotypic and functional properties of an encephalitogenic T-helper lymphocyte line.
Cellular immunology 1985;95(1):84-94.
1985: Offner H; Standage B A; Burger D R; Vandenbark A A
Delayed type hypersensitivity to gangliosides in the Lewis rat.
Journal of neuroimmunology 1985;9(3-4):147-57.
1985: Vandenbark A A; Offner H; Reshef T; Fritz R; Chou C H; Cohen I R
Specificity of T lymphocyte lines for peptides of myelin basic protein.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(1):229-33.
1985: Vandenbark A A; Gill T; Offner H
A myelin basic protein-specific T lymphocyte line that mediates experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(1):223-8.
1985: Vandenbark A A; De Saedeleer J; Heyligen H; Dom R; Raus J; Stragier J; Carton H
Leu-3+ lymphocytes account for increased CSF cellularity.
Journal of neuroimmunology 1985;8(2-3):103-14.
1983: Tong A W; Vandenbark A A; Kraybill W; Regan D; Burger D R
Detection of antigen specific rosette formation with the FACS.
Journal of immunological methods 1983;56(1):63-74.
1982: Anderson D J; Alexander N J; Fulgham D L; Vandenbark A A; Burger D R
Immunity to tumor-associated antigens in vasectomized men.
Journal of the National Cancer Institute 1982;69(3):551-5.
1982: White M W; Vandenbark A A; Barney C L; Ferro A J
Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation.
Biochemical pharmacology 1982;31(4):503-7.
1981: Bagby G C; Rigas V D; Bennett R M; Vandenbark A A; Garewal H S
Interaction of lactoferrin, monocytes, and T lymphocyte subsets in the regulation of steady-state granulopoiesis in vitro.
The Journal of clinical investigation 1981;68(1):56-63.
1981: Vandenbark A A; Yoshihara P; Carveth L; Burger D R
All KLH preparations are not created equal.
Cellular immunology 1981;60(1):240-3.
1981: Ferro A J; Vandenbark A A; MacDonald M R
Inactivation of S-adenosylhomocysteine hydrolase by 5'-deoxy-5'-methylthioadenosine.
Biochemical and biophysical research communications 1981;100(2):523-31.
1980: Stubbs E G; Budden S S; Burger D R; Vandenbark A A
Transfer factor immunotherapy of an autistic child with congenital cytomegalovirus.
Journal of autism and developmental disorders 1980;10(4):451-8.
1980: Dunnick W; Burger D R; Vandenbark A A
Lack of antigen fragments in guinea pig transfer factor-like activity.
Clinical immunology and immunopathology 1980;17(1):55-65.
1980: Vandenbark A A; Ferro A J; Barney C L
Inhibition of lymphocyte transformation by a naturally occurring metabolite: 5'-methylthioadenosine.
Cellular immunology 1980;49(1):26-33.
1979: Ferro A J; Vandenbark A A; Marchitto K
The role of 5'-methylthioadenosine phosphorylase in 5'-methylthioadenosine-mediated inhibition of lymphocyte transformation.
Biochimica et biophysica acta 1979;588(3):294-301.
1979: Vandenbark A A; Greene M H; Burger D R; Vetto R M; Reimer R R
Immune response to melanoma extracts in three melanoma-prone families.
Journal of the National Cancer Institute 1979;63(5):1147-51.
1979: Vandenbark A A; Hallum J V; Swank R L; Tong A; Burger D R
Myelin basic protein binding cells in active multiple sclerosis.
Annals of neurology 1979;6(1):8-12.
1979: Burger D R; Klesius P H; Vandenbark A A; Vetto R M; Swann A I
Transfer of keyhole limpet hemocyanin dermal reactivity to man with bovine transfer factor.
Cellular immunology 1979;43(1):192-6.
1979: Burger D R; Vandenbark A A; Dunnick W; Kraybill W; Daves G D; Vetto R M
Human transfer factors: structural properties suggested by HPRP chromatography and enzymatic sensitivities.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(3):1091-8.
1979: Tong A W; Burger D R; Finke P; Barney C; Vandenbark A A; Vetto R M
Assessment of the mechanism of the leukocyte adherence inhibition test.
Cancer research 1979;39(2 Pt 2):597-603.
1979: Malley A; Burger D R; Vandenbark A A; Frikke M; Finke P; Begley D; Acott K; Black J; Vetto R M
Association of melanoma tumor antigen activity with beta2-microglobulin.
Cancer research 1979;39(2 Pt 2):619-23.
1979: Burger D R; Wampler P A; Vandenbark A A; Regan D H
A structural model for human transfer factor.
Annals of the New York Academy of Sciences 1979;332():236-40.
1978: Burger D R; Vandenbark A A; Dunnick W; Kraybill W G; Vetto R M
Properties of human transfer factor from KLH-immunized donors: dissociation of dermal transfer and proliferation augmenting activities.
Journal of the Reticuloendothelial Society 1978;24(4):385-402.
1978: Vetto R M; Burger D R; Vandenbark A A; Finke P E
Changes in tumor immunity during therapy determined by leukocyte adherence inhibition and dermal testing.
Cancer 1978;41(3):1034-9.
1977: Vandenbark A A; Burger D R; Vetto R M
Human transfer factor activity in the guinea pig: absence of antigen specificity.
Clinical immunology and immunopathology 1977;8(1):7-16.
1977: Burger D R; Vandenbark A A; Finke P; Vetto R M
De novo appearance of KLH transfer factor following immunization.
Cellular immunology 1977;29(2):410-3.
1977: Vandenbark A A; Burger D R; Dreyer D L; Daves G D; Vetto R M
Human transfer factor: fractionation by electrofocusing and high pressure, reverse phase chromatography.
Journal of immunology (Baltimore, Md. : 1950) 1977;118(2):636-41.
1976: Burger D R; Vandenbark A A; Finke P; Nolte J E; Vetto R M
Human transfer factor: effects on lymphocyte transformation.
Journal of immunology (Baltimore, Md. : 1950) 1976;117(3):782-8.
1976: Burger D R; Vandenbark A A; Daves D; Anderson W A; Vetto R M; Finke P
Nicotinamide: suppression of lymphocyte transformation with a component identified in human transfer factor.
Journal of immunology (Baltimore, Md. : 1950) 1976;117(3):797-801.
1976: Burger D R; Vandenbark A A; Daves D; Anderson W A; Vetto R M; Finke P
Human transfer factor: fractionation and biologic activity.
Journal of immunology (Baltimore, Md. : 1950) 1976;117(3):789-96.
1976: Burger D R; Finke P; Vandenbark A A; Tong A; Vetto R M; Campbell J R
Letter: Sensitisation to neuroblastoma.
Lancet 1976;2(7980):310.
1976: Vandenbark A A; Burger D R; Finke P; Vetto R M
The effects of plasma from guinea pigs with tumor on PHA stimulated lymphocyte cultures.
Cellular immunology 1976;22(2):334-44.
1976: Vandenbark A A; Burger D R; Vetto R M
Automated counting of T cell rosettes.
Journal of immunological methods 1976;10(2-3):261-70.
1976: Vetto R M; Burger D R; Nolte J E; Vandenbark A A; Baker H W
Transfer factor therapy in patients with cancer.
Cancer 1976;37(1):90-7.
1975: Vetto R M; Burger D R; Vandenbark A A; Nolte J
Influence of serum blocking factors on cancer patients undergoing immunotherapy.
American journal of surgery 1975;130(2):237-43.
1975: Vandenbark A A; Burger D R; Vetto R M
Cell-mediated immunity in experimental allergic encephalomyelitis: cross reactivity between myelin basic protein and mycobacteria antigens.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1975;148(4):1233-6.
1974: Burger D R; Vetto R M; Vandenbark A A
Preparation of human transfer factor: a time-saving modification for preparing dialyzable transfer factor.
Cellular immunology 1974;14(2):332-3.
1974: Vandenbark A A; Hinrichs D J
Experimental allergic encephalomyelitis and cellular immunity in the Lewis rat.
Cellular immunology 1974;12(1):85-93.
1974: Vandenbark A A; Gibbins B L; Hinrichs D J
Immunosuppressive activity of serum during the development of experimental allergic encephalomyelitis.
Cellular immunology 1974;11(1-3):1-10.
1974: Burger D R; Vetto R M; Vandenbark A A
Transfer factor immunotherapy in human cancer.
Surgical forum 1974;25(0):93-5.

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