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Guillermo García-Cardeña

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Anatomy

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Andrew Koo; C Forbes Dewey; Guillermo García-Cardeña
Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells.
Giusi Marrone; Eugenio Rosado; Lucia Russo; Diana Hide; Jaime Bosch; Guillermo García-Cardeña; Juan Carlos García-Pagán; Jorge Gracia-Sancho
The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins.
Michael A Gimbrone; Guillermo García-Cardeña
Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis.

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All Publications

2013: Andrew Koo; C Forbes Dewey; Guillermo García-Cardeña
Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells.
American journal of physiology. Cell physiology 2013;304(2):C137-46.
2013: Giusi Marrone; Eugenio Rosado; Lucia Russo; Diana Hide; Jaime Bosch; Guillermo García-Cardeña; Juan Carlos García-Pagán; Jorge Gracia-Sancho
The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins.
Journal of hepatology 2013;58(1):98-103.
2013: Michael A Gimbrone; Guillermo García-Cardeña
Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2013;22(1):9-15.
2012: William J Adams; Guillermo García-Cardeña
Novel stem cell-based drug discovery platforms for cardiovascular disease.
Journal of biomolecular screening 2012;17(9):1117-27.
2012: Marc-Olivier Timsit; Guillermo García-Cardeña
Flow-dependent endothelial function and kidney dysfunction.
Seminars in nephrology 2012;32(2):185-91.
2012: Lucia Russo; Héctor García-Calderó; Guillermo García-Cardeña; Juan Carlos García-Pagán; Jorge Gracia-Sancho; Giusi Marrone; Jaime Bosch
Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers.
Hepatology (Baltimore, Md.) 2012;55(3):921-30.
2011: Luigi Adamo; Guillermo García-Cardeña
Directed stem cell differentiation by fluid mechanical forces.
Antioxidants & redox signaling 2011;15(5):1463-73.
2011: Wei Wu; Han Xiao; Yuzhi Zhang; Jing Zhou; Shu Chien; Guillermo García-Cardeña; Greg G Geary; Hsien-Da Huang; Andrés Laguna-Fernandez; Yi-Shuan Li; Guadalupe Villarreal; Kuei-Chun Wang; Wei-Chi Wang; John Y-J Shyy
Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a.
Circulation 2011;124(5):633-41.
2011: Jorge Gracia-Sancho; Lucia Russo; Héctor García-Calderó; Juan Carlos García-Pagán; Guillermo García-Cardeña; Jaime Bosch
Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver.
Gut 2011;60(4):517-24.
2010: Jorge Gracia-Sancho; Guadalupe Villarreal; Yuzhi Zhang; Jessica X Yu; Yao Liu; Stefan G Tullius; Guillermo García-Cardeña
Flow cessation triggers endothelial dysfunction during organ cold storage conditions: strategies for pharmacologic intervention.
Transplantation 2010;90(2):142-9.
2010: De-xiu Bu; Margarite Tarrio; Nir Grabie; Yuzhi Zhang; Hiroyuki Yamazaki; George Stavrakis; Elena Maganto-Garcia; Zachary Pepper-Cunningham; Petr Jarolim; Masanori Aikawa; Guillermo García-Cardeña; Andrew H Lichtman
Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.
The Journal of clinical investigation 2010;120(6):1961-70.
2010: Xiaodong Yuan; Ashok J Theruvath; Xupeng Ge; Bernhard Floerchinger; Anke Jurisch; Guillermo García-Cardeña; Stefan G Tullius
Machine perfusion or cold storage in organ transplantation: indication, mechanisms, and future perspectives.
Transplant international : official journal of the European Society for Organ Transplantation 2010;23(6):561-70.
2010: Eli J Weinberg; Peter J Mack; Frederick J Schoen; Guillermo García-Cardeña; Mohammad MR Kaazempur-Mofrad
Hemodynamic environments from opposing sides of human aortic valve leaflets evoke distinct endothelial phenotypes in vitro.
Cardiovascular engineering (Dordrecht, Netherlands) 2010;10(1):5-11.
2010: Jorge Gracia-Sancho; Guadalupe Villarreal; Yuzhi Zhang; Guillermo García-Cardeña
Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype.
Cardiovascular research 2010;85(3):514-9.
2010: Jeffrey Borenstein; Malinda M Tupper; Peter J Mack; Eli J Weinberg; Ahmad S Khalil; James Hsiao; Guillermo García-Cardeña
Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate.
Biomedical microdevices 2010;12(1):71-9.
2010: Guadalupe Villarreal; Yuzhi Zhang; H Benjamin Larman; Jorge Gracia-Sancho; Andrew Koo; Guillermo García-Cardeña
Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells.
Biochemical and biophysical research communications 2010;391(1):984-9.
2009: Angela Young; Wei Wu; Wei Sun; H Benjamin Larman; Harry B Larman; Nanping Wang; Yi-Shuan Li; John Y Shyy; Shu Chien; Guillermo García-Cardeña
Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(11):1902-8.
2009: Luigi Adamo; Olaia Naveiras; Pamela L Wenzel; Shannon L McKinney-Freeman; Peter J Mack; Jorge Gracia-Sancho; Astrid Suchy-Dicey; Momoko Yoshimoto; M William Lensch; Mervin C Yoder; Guillermo García-Cardeña; George Q Daley
Biomechanical forces promote embryonic haematopoiesis.
Nature 2009;459(7250):1131-5.
2009: Peter J Mack; Yuzhi Zhang; Seok Chung; Vernella Vickerman; Roger Kamm; Guillermo García-Cardeña
Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling.
The Journal of biological chemistry 2009;284(13):8412-20.
2009: Luigi Adamo; Yuzhi Zhang; Guillermo García-Cardeña
AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts.
BMC pharmacology 2009;9():2.
2009: Stefan G Tullius; Guillermo García-Cardeña
Organ procurement and perfusion before transplantation.
The New England journal of medicine 2009;360(1):78-80.
2008: Meng Liu; Martin S Kluger; Alessio D'Alessio; Guillermo García-Cardeña; Jordan S Pober
Regulation of arterial-venous differences in tumor necrosis factor responsiveness of endothelial cells by anatomic context.
The American journal of pathology 2008;172(4):1088-99.
2007: Guohao Dai; Saran Vaughn; Yuzhi Zhang; Eric T Wang; Guillermo García-Cardeña; Michael A Gimbrone
Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.
Circulation research 2007;101(7):723-33.
2007: Ravi M Rao; Lin Yang; Guillermo García-Cardeña; Francis W Luscinskas
Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall.
Circulation research 2007;101(3):234-47.
2006: Deborah Abeles; Stephanie Kwei; George Stavrakis; Yuzhi Zhang; Eric T Wang; Guillermo García-Cardeña
Gene expression changes evoked in a venous segment exposed to arterial flow.
Journal of vascular surgery 2006;44(4):863-70.
2006: Guillermo García-Cardeña; Michael A Gimbrone
Biomechanical modulation of endothelial phenotype: implications for health and disease.
Handbook of experimental pharmacology 2006;(176 Pt 2):79-95.
2006: Kush M Parmar; H Benjamin Larman; Guohao Dai; Yuzhi Zhang; Eric T Wang; Sripriya N Moorthy; Johannes R Kratz; Zhiyong Lin; Mukesh K Jain; Michael A Gimbrone; Guillermo García-Cardeña
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.
The Journal of clinical investigation 2006;116(1):49-58.
2005: Kush M Parmar; Vinod Nambudiri; Guohao Dai; H Benjamin Larman; Michael A Gimbrone; Guillermo García-Cardeña
Statins exert endothelial atheroprotective effects via the KLF2 transcription factor.
The Journal of biological chemistry 2005;280(29):26714-9.
2005: Zhiyong Lin; Ajay Kumar; Sucharita SenBanerjee; Kristine Staniszewski; Kush M Parmar; Douglas E Vaughan; Michael A Gimbrone; Viji Balasubramanian; Guillermo García-Cardeña; Mukesh K Jain
Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function.
Circulation research 2005;96(5):e48-57.
2004: Guohao Dai; Mohammad MR Kaazempur-Mofrad; Sripriya Natarajan; Yuzhi Zhang; Saran Vaughn; Brett R Blackman; Roger Kamm; Guillermo García-Cardeña; Michael A Gimbrone
Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14871-6.
2004: Elena Rabkin-Aikawa; Masanori Aikawa; Mark Farber; Johannes R Kratz; Guillermo García-Cardeña; Nicholas T Kouchoukos; Max B Mitchell; Richard A Jonas; Frederick J Schoen
Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site.
The Journal of thoracic and cardiovascular surgery 2004;128(4):552-61.
2004: Sucharita SenBanerjee; Zhiyong Lin; G Brandon Atkins; Daniel M Greif; Ravi M Rao; Ajay Kumar; Mark W Feinberg; Zhiping Chen; Daniel I Simon; Francis W Luscinskas; Thomas Michel; Michael A Gimbrone; Guillermo García-Cardeña; Mukesh K Jain
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.
The Journal of experimental medicine 2004;199(10):1305-15.
2004: Jason Comander; Sripriya Natarajan; Michael A Gimbrone; Guillermo García-Cardeña
Improving the statistical detection of regulated genes from microarray data using intensity-based variance estimation.
BMC genomics 2004;5(1):17.
2004: Andreas Papapetropoulos; David J Fulton; Michelle I Lin; Jason Fontana; Timothy J McCabe; Stefan Zoellner; Guillermo García-Cardeña; Zongmin Zhou; Jean-Philippe Gratton; William C Sessa
Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein.
Molecular pharmacology 2004;65(2):407-15.
2004: Stephanie Kwei; George Stavrakis; Masaya Takahas; George Taylor; M Judah Folkman; Michael A Gimbrone; Guillermo García-Cardeña
Early adaptive responses of the vascular wall during venous arterialization in mice.
The American journal of pathology 2004;164(1):81-9.
2003: Jeanne-Marie Kiely; Yenya Hu; Guillermo García-Cardeña; Michael A Gimbrone
Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3216-24.
2003: Yaw-Chyn Lim; Guillermo García-Cardeña; Jennifer R Allport; Mandy Zervoglos; Andrew J Connolly; Michael A Gimbrone; Francis W Luscinskas
Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment.
The American journal of pathology 2003;162(5):1591-601.
2002: Brett R Blackman; Guillermo García-Cardeña; Michael A Gimbrone
A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms.
Journal of biomechanical engineering 2002;124(4):397-407.
2001: Guillermo García-Cardeña; Jason Comander; Brett R Blackman; KR Anderson; Michael A Gimbrone
Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis?
Annals of the New York Academy of Sciences 2001;947():1-6.
2001: Jason Comander; Griffin Weber; M A Gimbrone; Guillermo García-Cardeña
Argus--a new database system for Web-based analysis of multiple microarray data sets.
Genome research 2001;11(9):1603-10.
2001: D Shin; Guillermo García-Cardeña; S Hayashi; Sebastian S Gerety; T Asahara; George Stavrakis; J Isner; J Folkman; M A Gimbrone; David J Anderson
Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization.
Developmental biology 2001;230(2):139-50.
2000: Jean-Philippe Gratton; Jason Fontana; Daniel S O'Connor; Guillermo García-Cardeña; Timothy J McCabe; William C Sessa
Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1.
The Journal of biological chemistry 2000;275(29):22268-72.
2000: Guillermo García-Cardeña; KR Anderson; L Mauri; Michael A Gimbrone
Distinct mechanical stimuli differentially regulate the PI3K/Akt survival pathway in endothelial cells.
Annals of the New York Academy of Sciences 2000;902():294-7.
1999: V Shah; Reiner Wiest; Guillermo García-Cardeña; Gregory W Cadelina; Roberto J Groszmann; William C Sessa
Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension.
The American journal of physiology 1999;277(2 Pt 1):G463-8.
1999: Andreas Papapetropoulos; Guillermo García-Cardeña; T J Dengler; P C Maisonpierre; George D Yancopoulos; William C Sessa
Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.
Laboratory investigation; a journal of technical methods and pathology 1999;79(2):213-23.
1998: M Rocío Sierra-Honigmann; Anjali K Nath; C Murakami; Guillermo García-Cardeña; Andreas Papapetropoulos; William C Sessa; Lisa A Madge; Jeffrey S Schechner; M B Schwabb; Peter J Polverini; Jaime Flores-Riveros
Biological action of leptin as an angiogenic factor.
Science (New York, N.Y.) 1998;281(5383):1683-6.
1998: Guillermo García-Cardeña; R Fan; V Shah; R Sorrentino; Giuseppe Cirino; Andreas Papapetropoulos; William C Sessa
Dynamic activation of endothelial nitric oxide synthase by Hsp90.
Nature 1998;392(6678):821-4.
1998: Guillermo García-Cardeña; J Folkman
Is there a role for nitric oxide in tumor angiogenesis?
Journal of the National Cancer Institute 1998;90(8):560-1.
1998: Amy S Woodard; Guillermo García-Cardeña; M Leong; Joseph A Madri; William C Sessa; Lucia R Languino
The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration.
Journal of cell science 1998;111 ( Pt 4)():469-78.
1998: V Shah; Guillermo García-Cardeña; William C Sessa; Roberto J Groszmann
The hepatic circulation in health and disease: report of a single-topic symposium.
Hepatology (Baltimore, Md.) 1998;27(1):279-88.
1997: Andreas Papapetropoulos; Guillermo García-Cardeña; Joseph A Madri; William C Sessa
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
The Journal of clinical investigation 1997;100(12):3131-9.
1997: V Shah; F G Haddad; Guillermo García-Cardeña; J A Frangos; Albert Mennone; Roberto J Groszmann; William C Sessa
Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids.
The Journal of clinical investigation 1997;100(11):2923-30.
1997: Teresa Caulin-Glaser; Guillermo García-Cardeña; Philip M Sarrel; William C Sessa; Jeffrey R Bender
17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization.
Circulation research 1997;81(5):885-92.
1997: Guillermo García-Cardeña; Pavel Martasek; Bettie Sue Masters; P M Skidd; J Couet; Shengwen Li; M P Lisanti; William C Sessa
Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo.
The Journal of biological chemistry 1997;272(41):25437-40.
1997: Andreas Papapetropoulos; K M Desai; Radu Daniel Rudic; B Mayer; Rong Zhang; M P Ruiz-Torres; Guillermo García-Cardeña; Joseph A Madri; William C Sessa
Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro.
The American journal of pathology 1997;150(5):1835-44.
1997: Marcia A Wheeler; S D Smith; Guillermo García-Cardeña; C F Nathan; Robert M Weiss; William C Sessa
Bacterial infection induces nitric oxide synthase in human neutrophils.
The Journal of clinical investigation 1997;99(1):110-6.
1996: N M Atucha; V Shah; Guillermo García-Cardeña; W E Sessa; Roberto J Groszmann
Role of endothelium in the abnormal response of mesenteric vessels in rats with portal hypertension and liver cirrhosis.
Gastroenterology 1996;111(6):1627-32.
1996: Guillermo García-Cardeña; R Fan; David F Stern; J Liu; William C Sessa
Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1.
The Journal of biological chemistry 1996;271(44):27237-40.
1996: J Liu; Guillermo García-Cardeña; William C Sessa
Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization.
Biochemistry 1996;35(41):13277-81.
1996: Guillermo García-Cardeña; Phil Oh; J Liu; Jan Schnitzer; William C Sessa
Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6448-53.
1995: J Liu; Guillermo García-Cardeña; William C Sessa
Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme.
Biochemistry 1995;34(38):12333-40.
1995: William C Sessa; Guillermo García-Cardeña; J Liu; A Keh; Jennifer Pollock; J Bradley; S Thiru; I M Braverman; K M Desai
The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide.
The Journal of biological chemistry 1995;270(30):17641-4.