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HERBERT PINEDO

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Anatomy

Cultured Tumor Cells

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Co-Publications
Name
144
Peters, Godefridus
85
Boven, Epie
72
van Groeningen, Cees
71
Giaccone, Giuseppe
61
Lankelma, Jan
44
Broxterman, Henk
40
Vermorken, Jan
39
Haisma, Hidde
36
Van der Wilt, Clasina
35
van der Vijgh, Wim
35
Hoekman, Klaas
35
Scheper, Rik
35
Smid, Kees
34
Wagstaff, John
30
Schuurhuis, Gerrit

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Publications

TOP 3
Mauritz Robert; Peters Godefridus J; Kathmann Ietje; Teshale Habte; Noordhuis Paul; Comijn Elizabeth M; Pinedo Herbert M; Jansen Gerrit
Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.
de Gruijl Tanja D; van den Eertwegh Alfons J M; Pinedo Herbert M; Scheper Rik J
Whole-cell cancer vaccination: from autologous to allogeneic tumor- and dendritic cell-based vaccines.
Emmering J; Krak N C; Van der Hoeven J J M; Spreeuwenberg M D; Twisk J W R; Meijer S; Pinedo H M; Hoekstra O S
Preoperative [18F] FDG-PET after chemotherapy in locally advanced breast cancer: prognostic value as compared with histopathology.

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All Publications

2008: Mauritz Robert; Peters Godefridus J; Kathmann Ietje; Teshale Habte; Noordhuis Paul; Comijn Elizabeth M; Pinedo Herbert M; Jansen Gerrit
Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.
Cancer chemotherapy and pharmacology 2008;62(6):937-48.
2008: de Gruijl Tanja D; van den Eertwegh Alfons J M; Pinedo Herbert M; Scheper Rik J
Whole-cell cancer vaccination: from autologous to allogeneic tumor- and dendritic cell-based vaccines.
Cancer immunology, immunotherapy : CII 2008;57(10):1569-77.
2008: Emmering J; Krak N C; Van der Hoeven J J M; Spreeuwenberg M D; Twisk J W R; Meijer S; Pinedo H M; Hoekstra O S
Preoperative [18F] FDG-PET after chemotherapy in locally advanced breast cancer: prognostic value as compared with histopathology.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(9):1573-7.
2008: Park Byeong-Ho; Hwang Taeho; Liu Ta-Chiang; Sze Daniel Y; Kim Jae-Seok; Kwon Hyuk-Chan; Oh Sung Yong; Han Sang-Young; Yoon Jin-Han; Hong Sook-Hee; Moon Anne; Speth Kelly; Park Chohee; Ahn Young-Joo; Daneshmand Manijeh; Rhee Byung Geon; Pinedo Herbert M; Bell John C; Kirn David H
Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial.
The lancet oncology 2008;9(6):533-42.
2007: Fontijn Dennis; Adema Auke D; Bhakat Kishor K; Pinedo Herbert M; Peters Godefridus J; Boven Epie
O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells.
Molecular cancer therapeutics 2007;6(10):2807-15.
2007: Duyndam Monique C A; van Berkel Maria P A; Dorsman Josephine C; Rockx Davy A P; Pinedo Herbert M; Boven Epie
Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells.
Biochemical pharmacology 2007;74(2):191-201.
2007: Eekhoff E M W; Pinedo H M; Lips P
[Osteoporosis in patients under treatment for cancer and the possibilities for prevention and treatment]
Nederlands tijdschrift voor geneeskunde 2007;151(25):1388-93.
2007: Verheul Henk M W; Pinedo Herbert M
Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition.
Nature reviews. Cancer 2007;7(6):475-85.
2007: Fontijn Dennis; Duyndam Monique C A; Beliën Jeroen A M; Gallegoz Ruiz Marielle I; Pinedo Herbert M; Boven Epie
The 18 kDa isoform of basic fibroblast growth factor is sufficient to stimulate human melanoma growth and angiogenesis.
Melanoma research 2007;17(3):155-68.
2007: Mauritz Robert; van Groeningen Cees J; Smid Kees; Jansen Gerrit; Pinedo Herbert M; Peters Godefridus J
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer.
International journal of cancer. Journal international du cancer 2007;120(12):2609-12.
2007: Giovannetti E; Backus H H J; Wouters D; Ferreira C G; van Houten V M M; Brakenhoff R H; Poupon M-F; Azzarello A; Pinedo H M; Peters G J
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
British journal of cancer 2007;96(5):769-75.
2006: Santegoets Saskia J A M; Masterson Allan J; van der Sluis Pieter C; Lougheed Sinéad M; Fluitsma Donna M; van den Eertwegh Alfons J M; Pinedo Herbert M; Scheper Rik J; de Gruijl Tanja D
A CD34(+) human cell line model of myeloid dendritic cell differentiation: evidence for a CD14(+)CD11b(+) Langerhans cell precursor.
Journal of leukocyte biology 2006;80(6):1337-44.
2006: Kroep J R; Smit E F; Giaccone G; Van der Born K; Beijnen J H; Van Groeningen C J; Van der Vijgh W J F; Postmus P E; Pinedo H M; Peters G J
Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer.
Cancer chemotherapy and pharmacology 2006;58(4):509-16.
2006: Hanna Michael G; Hoover Herbert C; Pinedo H M; Finer Mitchell
Active specific immunotherapy with autologous tumor cell vaccines for stage II colon cancer: logistics, efficacy, safety and immunological Pharmacodynamics.
Human vaccines 2006;2(4):185-91.
2006: Boddaert Manon S A; Gerritsen Winald R; Pinedo Herbert M
On our way to targeted therapy for cachexia in cancer?
Current opinion in oncology 2006;18(4):335-40.
2006: de Gruijl Tanja D; Sombroek Claudia C; Lougheed Sinéad M; Oosterhoff Dinja; Buter Jan; van den Eertwegh Alfons J M; Scheper Rik J; Pinedo Herbert M
A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7232-42.
2006: Fontijn D; Duyndam M C A; van Berkel M P A; Yuana Y; Shapiro L H; Pinedo H M; Broxterman H J; Boven E
CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells.
British journal of cancer 2006;94(11):1627-36.
2006: Haanen J B A G; Baars A; Gomez R; Weder P; Smits M; de Gruijl T D; von Blomberg B M E; Bloemena E; Scheper R J; van Ham S M; Pinedo H M; van den Eertwegh A J M
Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients.
Cancer immunology, immunotherapy : CII 2006;55(4):451-8.
2006: Peters Godefridus J; Van Moorsel Catharina J A; Lakerveld Bianca; Smid Kees; Noordhuis Paul; Comijn Elizabeth C; Weaver Dennis; Willey James C; Voorn Daphne; Van der Vijgh Wim J F; Pinedo Herbert M
Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines.
International journal of oncology 2006;28(1):237-44.
2006: Smorenburg C H; Peters G J; van Groeningen C J; Noordhuis P; Smid K; van Riel A M G H; Dercksen W; Pinedo H M; Giaccone G
Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(1):35-42.
2005: Hansma A H G; Broxterman H J; van der Horst I; Yuana Y; Boven E; Giaccone G; Pinedo H M; Hoekman K
Recombinant human endostatin administered as a 28-day continuous intravenous infusion, followed by daily subcutaneous injections: a phase I and pharmacokinetic study in patients with advanced cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(10):1695-701.
2005: Kuenen Bart C; Giaccone Giuseppe; Ruijter Rita; Kok Astrid; Schalkwijk Casper; Hoekman Klaas; Pinedo Herbert M
Dose-finding study of the multitargeted tyrosine kinase inhibitor SU6668 in patients with advanced malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6240-6.
2005: Codacci-Pisanelli G; Pinedo H M; Lankelma J; Van Groeningen C J; Van Kuilenburg A B P; Van Gennip A H; Peters G J
Pharmacokinetics of bolus 5-fluorouracil: relationship between dose, plasma concentrations, area-under-the-curve and toxicity.
Journal of chemotherapy (Florence, Italy) 2005;17(3):315-20.
2005: Oosterhoff D; Pinedo H M; Witlox M A; Carette J E; Gerritsen W R; van Beusechem V W
Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdDelta24.
Gene therapy 2005;12(12):1011-8.
2005: Verheul Henk M W; Pinedo Herbert M
Inhibition of angiogenesis in cancer patients.
Expert opinion on emerging drugs 2005;10(2):403-12.
2005: Oosterhoff D; Overmeer R M; de Graaf M; van der Meulen I H; Giaccone G; van Beusechem V W; Haisma H J; Pinedo H M; Gerritsen W R
Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11.
British journal of cancer 2005;92(5):882-7.
2005: Middelburg Rutger; de Haas Richard R; Dekker Henk; Kerkhoven Ron M; Pohlmann Paula R; Fuentes-Alburo Adolfo; Mohar Alejandro; Pinedo Herbert M; Lankelma Jan
Induction of p53 up-regulated modulator of apoptosis messenger RNA by chemotherapeutic treatment of locally advanced breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1863-9.
2005: Uyl-de Groot C A; Vermorken J B; Hanna M G; Verboom P; Groot M T; Bonsel G J; Meijer C J L M; Pinedo H M
Immunotherapy with autologous tumor cell-BCG vaccine in patients with colon cancer: a prospective study of medical and economic benefits.
Vaccine 2005;23(17-18):2379-87.
2004: de Graaf Michelle; Nevalainen Tapio J; Scheeren Hans W; Pinedo Herbert M; Haisma Hidde J; Boven Epie
A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy.
Biochemical pharmacology 2004;68(11):2273-81.
2004: de Bruin M; van Capel T; Smid K; van der Born K; Fukushima M; Hoekman K; Pinedo H M; Peters G J
Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1485-90.
2004: Mauritz R; Beumer I J; Marsh S; McLeod H L; Smid K; van Groeningen C J; Pinedo H M; Peters G J
Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1381-4.
2004: de Bruin M; Smid K; van der Ent M A; Fukushima M; Pinedo H M; Peters G J
Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1367-70.
2004: de Bruin Michiel; Peters Godefridus J; Oerlemans Ruud; Assaraf Yehuda G; Masterson Allan J; Adema Auke D; Dijkmans Ben A C; Pinedo Herbert M; Jansen Gerrit
Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells.
Molecular pharmacology 2004;66(4):1054-60.
2004: van der Vliet Hans J J; Molling Johan W; von Blomberg B Mary E; Nishi Nobusuke; Kölgen Wendy; van den Eertwegh Alfons J M; Pinedo Herbert M; Giaccone Giuseppe; Scheper Rik J
The immunoregulatory role of CD1d-restricted natural killer T cells in disease.
Clinical immunology (Orlando, Fla.) 2004;112(1):8-23.
2004: Noordhuis P; Holwerda U; Van der Wilt C L; Van Groeningen C J; Smid K; Meijer S; Pinedo H M; Peters G J
5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(7):1025-32.
2004: De Bruin Michiel; Van Capel Toni; Smid Kees; Fukushima Masakazu; Hoekman Klaas; Pinedo Herbert M; Peters Godefridus J
The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase.
European journal of pharmacology 2004;491(2-3):93-9.
2004: Hansma A H G; van Hensbergen Y; Kuenen B C; van Diest P J; Hanemaaijer R; Meijer S; Pinedo H M; Hoekman K
A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour.
Journal of clinical pathology 2004;57(5):536-8.
2004: Verweij J; de Mulder P H; Pinedo H M
[The Dutch Health Council report on palliative chemotherapy: possible confusion on ideas]
Nederlands tijdschrift voor geneeskunde 2004;148(14):651-4.
2004: van der Hoeven Jacobus J M; Krak Nanda C; Hoekstra Otto S; Comans Emile F I; Boom Robert P A; van Geldere Dick; Meijer Sybren; van der Wall Elsken; Buter Jan; Pinedo Herbert M; Teule Gerrit J J; Lammertsma Adriaan A
18F-2-fluoro-2-deoxy-d-glucose positron emission tomography in staging of locally advanced breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(7):1253-9.
2004: de Graaf Michelle; Pinedo Herbert M; Oosterhoff Dinja; van der Meulen-Muileman Ida H; Gerritsen Winald R; Haisma Hidde J; Boven Epie
Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein.
Human gene therapy 2004;15(3):229-38.
2004: De Lange S M; van Groeningen C J; Kroep J R; Van Bochove A; Snijders J F; Peters G J; Pinedo H M; Giaccone G
Phase II trial of cisplatin and gemcitabine in patients with advanced gastric cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(3):484-8.
2004: van Hensbergen Yvette; Broxterman Henk J; Rana Sareena; van Diest Paul J; Duyndam Monique C A; Hoekman Klaas; Pinedo Herbert M; Boven Epie
Reduced growth, increased vascular area, and reduced response to cisplatin in CD13-overexpressing human ovarian cancer xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1180-91.
2004: Kroep J R; Pinedo H M; Giaccone G; Van Bochove A; Peters G J; Van Groeningen C J
Phase II study of cisplatin preceding gemcitabine in patients with advanced oesophageal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(2):230-5.
2004: Witlox Adhiambo M; Van Beusechem Victor W; Molenaar Bonnie; Bras Hans; Schaap Gerard R; Alemany Ramon; Curiel David T; Pinedo Herbert M; Wuisman Paul I J M; Gerritsen Winald R
Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):61-7.
2004: van Riel J M G H; van Groeningen C J; de Greve J; Gruia G; Pinedo H M; Giaccone G
Continuous infusion of hepatic arterial irinotecan in pretreated patients with colorectal cancer metastatic to the liver.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(1):59-63.
2004: Hoekman K; Pinedo H M
Angiogenesis: a potential target for therapy of soft tissue sarcomas.
Cancer treatment and research 2004;120():169-80.
2003: Bos Reinhard; van Diest Paul J; van der Groep Petra; Greijer Astrid E; Hermsen Mario A J A; Heijnen Ingrid; Meijer Gerrit A; Baak Jan P A; Pinedo Herbert M; van der Wall Elsken; Shvarts Avi
Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha).
Oncogene 2003;22(55):8948-51.
2003: van Beusechem V W; Mastenbroek D C J; van den Doel P B; Lamfers M L M; Grill J; Würdinger T; Haisma H J; Pinedo H M; Gerritsen W R
Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors.
Gene therapy 2003;10(23):1982-91.
2003: Baars A; Pinedo H M
[Good response to treatment with the selective tyrosine-kinase inhibitor imatinib in a patient with metastatic dermatofibrosarcoma protuberans]
Nederlands tijdschrift voor geneeskunde 2003;147(42):2072-6.
2003: Kuenen B C; Pinedo H M
[New oncological treatment principle with imatinib]
Nederlands tijdschrift voor geneeskunde 2003;147(42):2044-5.
2003: Stam A G M; Santegoets S J A M; Westers T M; Sombroek C C; Janssen J J W M; Tillman B W; van de Loosdrecht A A; Pinedo H M; Curiel D T; Ossenkoppele G J; Scheper R J; de Gruijl T D
CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation.
British journal of cancer 2003;89(7):1162-5.
2003: Kroep Judith R; Van Groeningen Cornelis J; Cuesta Miguel A; Craanen Mike E; Hoekstra Otto S; Comans Emile F I; Bloemena Elisabeth; Hoekstra Corneline J; Golding Richard P; Twisk Jos W R; Peters Godefridus J; Pinedo Herbert M; Lammertsma Adriaan A
Positron emission tomography using 2-deoxy-2-[18F]-fluoro-D-glucose for response monitoring in locally advanced gastroesophageal cancer; a comparison of different analytical methods.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2003;5(5):337-46.
2003: Verheul Henk M W; Pinedo Herbert M
The importance of platelet counts and their contents in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(9):3219-21.
2003: Oosterhoff Dinja; Witlox M Adhiambo; van Beusechem Victor W; Haisma Hidde J; Schaap Gerard R; Bras Johannes; Kruyt Frank A; Molenaar Bonnie; Boven Epie; Wuisman Paul I J M; Pinedo Herbert M; Gerritsen Winald R
Gene-directed enzyme prodrug therapy for osteosarcoma: sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2.
Molecular cancer therapeutics 2003;2(8):765-71.
2003: Lankelma Jan; Fernández Luque Rafael; Dekker Henk; Pinedo Herbert M
Simulation model of doxorubicin activity in islets of human breast cancer cells.
Biochimica et biophysica acta 2003;1622(3):169-78.
2003: van der Vliet Hans J J; Molling Johan W; Nishi Nobusuke; Masterson Allan J; Kölgen Wendy; Porcelli Steven A; van den Eertwegh Alfons J M; von Blomberg B Mary E; Pinedo Herbert M; Giaccone Giuseppe; Scheper Rik J
Polarization of Valpha24+ Vbeta11+ natural killer T cells of healthy volunteers and cancer patients using alpha-galactosylceramide-loaded and environmentally instructed dendritic cells.
Cancer research 2003;63(14):4101-6.
2003: Pinedo Herbert M
Thrombosis, prevalence and new evidence on current perceptions of risk.
Cancer treatment reviews 2003;29 Suppl 2():3-5.
2003: Bergman A M; Pinedo H M; Talianidis I; Veerman G; Loves W J P; van der Wilt C L; Peters G J
Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines.
British journal of cancer 2003;88(12):1963-70.
2003: Braybrooke J P; Boven E; Bates N P; Ruijter R; Dobbs N; Cheverton P D; Pinedo H M; Talbot D C
Phase I and pharmacokinetic study of the topoisomerase I inhibitor, exatecan mesylate (DX-8951f), using a weekly 30-minute intravenous infusion, in patients with advanced solid malignancies.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(6):913-21.
2003: de Graaf Michelle; Pinedo Herbert M; Quadir Razi; Haisma Hidde J; Boven Epie
Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin.
Biochemical pharmacology 2003;65(11):1875-81.
2003: Kuenen B C; Levi M; Meijers J C M; van Hinsbergh V W M; Berkhof J; Kakkar A K; Hoekman K; Pinedo H M
Potential role of platelets in endothelial damage observed during treatment with cisplatin, gemcitabine, and the angiogenesis inhibitor SU5416.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(11):2192-8.
2003: Backus H H J; Wouters D; Ferreira C G; van Houten V M M; Brakenhoff R H; Pinedo H M; Peters G J
Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.
European journal of cancer (Oxford, England : 1990) 2003;39(9):1310-7.
2003: Brandão Joana G; Scheper Rik J; Lougheed Sinéad M; Curiel David T; Tillman Bryan W; Gerritsen Winald R; van den Eertwegh Alfons J M; Pinedo Herbert M; Haisma Hidde J; de Gruijl Tanja D
CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation.
Vaccine 2003;21(19-20):2268-72.
2003: Pinedo H M; Buter J; Luykx-de Bakker S A; Pohlmann P R; van Hensbergen Y; Heideman D A M; van Diest P J; de Gruijl T D; van der Wall E
Extended neoadjuvant chemotherapy in locally advanced breast cancer combined with GM-CSF: effect on tumour-draining lymph node dendritic cells.
European journal of cancer (Oxford, England : 1990) 2003;39(8):1061-7.
2003: Buter Jan; Pinedo Herbert M
Neoadjuvant chemoimmunotherapy in locally advanced breast cancer: a new avenue to be explored.
Current oncology reports 2003;5(3):171-6.
2003: de Bruin M; van Capel T; Van der Born K; Kruyt F A; Fukushima M; Hoekman K; Pinedo H M; Peters G J
Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity.
British journal of cancer 2003;88(6):957-64.
2003: Bos Reinhard; van der Groep Petra; Greijer Astrid E; Shvarts Avi; Meijer Sybren; Pinedo Herbert M; Semenza Gregg L; van Diest Paul J; van der Wall Elsken
Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma.
Cancer 2003;97(6):1573-81.
2003: de Bruin M; Smid K; Laan A C; Noordhuis P; Fukushima M; Hoekman K; Pinedo H M; Peters G J
Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells.
Biochemical and biophysical research communications 2003;301(3):675-9.
2003: Duyndam Monique C A; Hulscher Saskia T M; van der Wall Elsken; Pinedo Herbert M; Boven Epie
Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite.
The Journal of biological chemistry 2003;278(9):6885-95.
2003: Baars Arnold; Buter Jan; Pinedo Herbert M
Making use of the primary tumour.
BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25(1):79-86.
2003: Van Moorsel C J A; Smid K; Voorn D A; Bergman A M; Pinedo H M; Peters G J
Effect of gemcitabine and cis-platinum combinations on ribonucleotide and deoxyribonucleotide pools in ovarian cancer cell lines.
International journal of oncology 2003;22(1):201-7.
2003: Verheul H M W; Pinedo H M
Vascular endothelial growth factor and its inhibitors.
Drugs of today (Barcelona, Spain : 1998) 2003;39 Suppl C():81-93.
2003: Pinedo Herbert M
The role of VEGF in oncology: effects on hemostasis and thrombosis.
Pathophysiology of haemostasis and thrombosis 2003;33 Suppl 1():11-2.
2003: Kakkar Ajay K; Levine Mark; Pinedo H M; Wolff Robert; Wong John
Venous thrombosis in cancer patients: insights from the FRONTLINE survey.
The oncologist 2003;8(4):381-8.
2002: de Boer Fransien; Dräger Angelika M; Pinedo Herbert M; Kessler Floortje L; Monnee-van Muijen M; Weijers Geert; Westra Guus; van der Wall Elsken; Netelenbos Tanja; Oberink Jan W; Huijgens Peter C; Schuurhuis Gerrit J
Early apoptosis largely accounts for functional impairment of CD34+ cells in frozen-thawed stem cell grafts.
Journal of hematotherapy & stem cell research 2002;11(6):951-63.
2002: van Hensbergen Yvette; Broxterman Henk J; Hanemaaijer Roeland; Jorna Anita S; van Lent Natascha A; Verheul Henk M W; Pinedo Herbert M; Hoekman Klaas
Soluble aminopeptidase N/CD13 in malignant and nonmalignant effusions and intratumoral fluid.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3747-54.
2002: Giaccone Giuseppe; Punt Cornelis J A; Ando Yoshitaka; Ruijter Rita; Nishi Nobusuke; Peters Marlies; von Blomberg B Mary E; Scheper Rik J; van der Vliet Hans J J; van den Eertwegh Alfons J M; Roelvink Marja; Beijnen Jos; Zwierzina Heinz; Pinedo Herbert M
A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3702-9.
2002: Noorda E M; Vrouenraets B C; Nieweg O E; Pinedo H M; Kroon B B R
Isolated limb perfusion with melphalan for femoral metastases of breast cancer: case report.
Journal of surgical oncology 2002;81(4):209-12.
2002: van Beusechem Victor W; van den Doel Petra B; Grill Jacques; Pinedo Herbert M; Gerritsen Winald R
Conditionally replicative adenovirus expressing p53 exhibits enhanced oncolytic potency.
Cancer research 2002;62(21):6165-71.
2002: Grill Jacques; Lamfers Martine L M; van Beusechem Victor W; Dirven Clemens M; Pherai D Shareen; Kater Mathijs; Van der Valk Paul; Vogels Ronald; Vandertop W Peter; Pinedo Herbert M; Curiel David T; Gerritsen Winald R
The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):609-14.
2002: de Gruijl Tanja D; Luykx-de Bakker Sylvia A; Tillman Bryan W; van den Eertwegh Alfons J M; Buter Jan; Lougheed Sinéad M; van der Bij Gerben J; Safer A Mahmoud; Haisma Hidde J; Curiel David T; Scheper Rik J; Pinedo Herbert M; Gerritsen Winald R
Prolonged maturation and enhanced transduction of dendritic cells migrated from human skin explants after in situ delivery of CD40-targeted adenoviral vectors.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5322-31.
2002: Lamfers Martine L M; Grill Jacques; Dirven Clemens M F; Van Beusechem Victor W; Geoerger Birgit; Van Den Berg Jaap; Alemany Ramon; Fueyo Juan; Curiel David T; Vassal Gilles; Pinedo Herbert M; Vandertop W Peter; Gerritsen Winald R
Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy.
Cancer research 2002;62(20):5736-42.
2002: van Hattum Annemarie H; Pinedo Herbert M; Schlüper Hennie M M; Erkelens Caroline A M; Tohgo Akiko; Boven Epie
The activity profile of the hexacyclic camptothecin derivative DX-8951f in experimental human colon cancer and ovarian cancer.
Biochemical pharmacology 2002;64(8):1267-77.
2002: de Groot Franciscus M H; Broxterman Henk J; Adams Hans P H M; van Vliet Alexandra; Tesser Godefridus I; Elderkamp Yvonne W; Schraa Astrid J; Kok Robert Jan; Molema Grietje; Pinedo Herbert M; Scheeren Hans W
Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug.
Molecular cancer therapeutics 2002;1(11):901-11.
2002: Heideman Daniëlle A M; van Beusechem Victor W; Offerhaus G Johan A; Wickham Thomas J; Roelvink Peter W; Craanen Mikael E; Pinedo Herbert M; Meijer Chris J L M; Gerritsen Winald R
Selective gene transfer into primary human gastric tumors using epithelial cell adhesion molecule-targeted adenoviral vectors with ablated native tropism.
Human gene therapy 2002;13(14):1677-85.
2002: van Hattum A H; Hoogsteen I J; Schlüper H M M; Maliepaard M; Scheffer G L; Scheper R J; Kohlhagen G; Pommier Y; Pinedo H M; Boven E
Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity.
British journal of cancer 2002;87(6):665-72.
2002: Oosterhoff D; Pinedo H M; van der Meulen I H; de Graaf M; Sone T; Kruyt F A; van Beusechem V W; Haisma H J; Gerritsen W R
Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
British journal of cancer 2002;87(6):659-64.
2002: Kuenen B C; Levi M; Meijers J C M; Kakkar A K; van Hinsbergh V W M; Kostense P J; Pinedo H M; Hoekman K
Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(9):1500-5.
2002: Witlox M A; Van Beusechem V W; Grill J; Haisma H J; Schaap G; Bras J; Van Diest P; De Gast A; Curiel D T; Pinedo H M; Gerritsen W R; Wuisman P I J M
Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma.
The journal of gene medicine 2002;4(5):510-6.
2002: van der Vliet Hans J J; Pinedo Herbert M; von Blomberg B Mary E; van den Eertwegh Alfons J M; Scheper Rik J; Giaccone Giuseppe
Natural Killer T cells.
The lancet oncology 2002;3(9):574.
2002: Dirven Clemens M F; Grill Jacques; Lamfers Martine L M; Van der Valk Paul; Leonhart Angelique M; Van Beusechem Victor W; Haisma Hidde J; Pinedo Herbert M; Curiel David T; Vandertop W Peter; Gerritsen Winald R
Gene therapy for meningioma: improved gene delivery with targeted adenoviruses.
Journal of neurosurgery 2002;97(2):441-9.
2002: Van Hattum Annemarie H; Schlüper Hennie M M; Hausheer Frederick H; Pinedo Herbert M; Boven Epie
Novel camptothecin derivative BNP1350 in experimental human ovarian cancer: determination of efficacy and possible mechanisms of resistance.
International journal of cancer. Journal international du cancer 2002;100(1):22-9.
2002: Masterson Allan J; Sombroek Claudia C; De Gruijl Tanja D; Graus Yvo M F; van der Vliet Hans J J; Lougheed Sinéad M; van den Eertwegh Alfons J M; Pinedo Herbert M; Scheper Rik J
MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors.
Blood 2002;100(2):701-3.
2002: Peters G J; Backus H H J; Freemantle S; van Triest B; Codacci-Pisanelli G; van der Wilt C L; Smid K; Lunec J; Calvert A H; Marsh S; McLeod H L; Bloemena E; Meijer S; Jansen G; van Groeningen C J; Pinedo H M
Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
Biochimica et biophysica acta 2002;1587(2-3):194-205.
2002: de Boer Fransien; Kessler Floortje L; Netelenbos Tanja; Zweegman Sonja; Huijgens Peter C; van der Wall Elsken; van der Linden Jan A M; Pinedo Herbert M; Schuurhuis Gerrit Jan; Dräger Angelika M
Homing and clonogenic outgrowth of CD34(+) peripheral blood stem cells: a role for L-selectin?
Experimental hematology 2002;30(6):590-7.
2002: de Lange S M; van Groeningen C J; Meijer O W M; Cuesta M A; Langendijk J A; van Riel J M G H; Pinedo H M; Peters G J; Meijer S; Slotman B J; Giaccone G
Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer.
European journal of cancer (Oxford, England : 1990) 2002;38(9):1212-7.
2002: Baars A; van Riel J M G H; Cuesta M A; Jaspars E H; Pinedo H M; van den Eertwegh A J M
Metastasectomy and active specific immunotherapy for a large single melanoma metastasis.
Hepato-gastroenterology 2002;49(45):691-3.
2002: Boven E; Verschraagen M; Hulscher T M; Erkelens C A M; Hausheer F H; Pinedo H M; van der Vijgh W J F
BNP7787, a novel protector against platinum-related toxicities, does not affect the efficacy of cisplatin or carboplatin in human tumour xenografts.
European journal of cancer (Oxford, England : 1990) 2002;38(8):1148-56.
2002: Sombroek Claudia C; Stam Anita G M; Masterson Allan J; Lougheed Sinéad M; Schakel Marcel J A G; Meijer Chris J L M; Pinedo Herbert M; van den Eertwegh Alfons J M; Scheper Rik J; de Gruijl Tanja D
Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4333-43.
2002: Kroep Judith R; Loves Willem J P; van der Wilt Clasina L; Alvarez Enrique; Talianidis Iannis; Boven Epie; Braakhuis Boudewijn J M; van Groeningen Cornelis J; Pinedo Herbert M; Peters Godefridus J
Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity.
Molecular cancer therapeutics 2002;1(6):371-6.
2002: Baars A; Claessen A M E; Wagstaff J; Giaccone G; Scheper R J; Meijer S; Schakel M J A G; Gall H E; Meijer C J L M; Vermorken J B; Pinedo H M; van den Eertwegh A J M
A phase II study of active specific immunotherapy and 5-FU/Leucovorin as adjuvant therapy for stage III colon carcinoma.
British journal of cancer 2002;86(8):1230-4.
2002: van Hensbergen Yvette; Broxterman Henk J; Elderkamp Yvonne W; Lankelma Jan; Beers Judith C C; Heijn Marc; Boven Epie; Hoekman Klaas; Pinedo Herbert M
A doxorubicin-CNGRC-peptide conjugate with prodrug properties.
Biochemical pharmacology 2002;63(5):897-908.
2002: Kuenen Bart C; Rosen Lee; Smit Egbert F; Parson Mandy R N; Levi Marcel; Ruijter Rita; Huisman Holger; Kedde Marc A; Noordhuis Paul; van der Vijgh Wim J F; Peters Godefridus J; Cropp Gillian F; Scigalla Paul; Hoekman Klaus; Pinedo Herbert M; Giaccone Giuseppe
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(6):1657-67.
2002: Backus H H J; Van Groeningen C J; Vos W; Dukers D F; Bloemena E; Wouters D; Pinedo H M; Peters G J
Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases.
Journal of clinical pathology 2002;55(3):206-11.
2002: de Graaf M; Boven E; Oosterhoff D; van der Meulen-Muileman I H; Huls G A; Gerritsen W R; Haisma H J; Pinedo H M
A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug.
British journal of cancer 2002;86(5):811-8.
2002: van Beusechem Victor W; Grill Jacques; Mastenbroek D C Jeroen; Wickham Thomas J; Roelvink Peter W; Haisma Hidde J; Lamfers Martine L M; Dirven Clemens M F; Pinedo Herbert M; Gerritsen Winald R
Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished.
Journal of virology 2002;76(6):2753-62.
2002: Kolfschoten G M; Hulscher T M; Schrier S M; van Houten V M M; Pinedo H M; Boven E
Time-dependent changes in factors involved in the apoptotic process in human ovarian cancer cells as a response to cisplatin.
Gynecologic oncology 2002;84(3):404-12.
2002: Bergman Andries M; Pinedo Herbert M; Peters Godefridus J
Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2002;5(1):19-33.
2002: Kolfschoten Geertruida M; Hulscher Theresia M; Duyndam Monique C A; Pinedo Herbert M; Boven Epie
Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel.
Biochemical pharmacology 2002;63(4):733-43.
2002: de Boer F; Dräger A M; Pinedo H M; Kessler F L; van der Wall E; Jonkhoff A R; van der Lelie J; Huijgens P C; Ossenkoppele G J; Schuurhuis G J
Extensive early apoptosis in frozen-thawed CD34-positive stem cells decreases threshold doses for haematological recovery after autologous peripheral blood progenitor cell transplantation.
Bone marrow transplantation 2002;29(3):249-55.
2002: van Riel Johanna M G H; van Groeningen Cees J; Kedde Mark A; Gall Helen; Leisink Johanna M A; Gruia Gabriella; Pinedo Herbert M; van der Vijgh Wim J F; Giaccone Giuseppe
Continuous administration of irinotecan by hepatic arterial infusion: a phase I and pharmacokinetic study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):405-12.
2002: Duyndam Monique C A; Hilhorst Marion C G W; Schlüper Hennie M M; Verheul Henk M W; van Diest Paul J; Kraal Georg; Pinedo Herbert M; Boven Epie
Vascular endothelial growth factor-165 overexpression stimulates angiogenesis and induces cyst formation and macrophage infiltration in human ovarian cancer xenografts.
The American journal of pathology 2002;160(2):537-48.
2002: van der Vliet Hans J J; von Blomberg B Mary E; Hazenberg Mette D; Nishi Nobusuke; Otto Sigrid A; van Benthem Birgit H; Prins Maria; Claessen Frans A; van den Eertwegh Alfons J M; Giaccone Giuseppe; Miedema Frank; Scheper Rik J; Pinedo Herbert M
Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1490-5.
2002: Mauritz Robert; Peters Godefridus J; Priest David G; Assaraf Yehuda G; Drori Stavit; Kathmann Ietje; Noordhuis Paul; Bunni Marlene A; Rosowsky Andre; Schornagel Jan H; Pinedo Herbert M; Jansen Gerrit
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Biochemical pharmacology 2002;63(2):105-15.
2002: Bodar Evelien; Buter Jan; de Gruijl Tanja D; van der Wall Elsken W A; Pinedo Herbert M
Immunologic and biologic properties of the primary tumor during prolonged neoadjuvant chemoimmunotherapy.
Oncology (Williston Park, N.Y.) 2002;16(1 Suppl 1):32-9.
2002: Codacci-Pisanelli Giovanni; Van der Wilt Clasina L; Smid Kees; Noordhuis Paul; Voorn Daphne; Pinedo Herbert M; Peters Godefridus J
High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.
Oncology 2002;62(4):363-70.
2002: de Graaf Michelle; Boven Epie; Scheeren Hans W; Haisma Hidde J; Pinedo Herbert M
Beta-glucuronidase-mediated drug release.
Current pharmaceutical design 2002;8(15):1391-403.
2002: de Graaf Michelle; van der Meulen-Muileman Ida H; Pinedo Herbert M; Haisma Hidde J
Expression of scFvs and scFv fusion proteins in eukaryotic cells.
Methods in molecular biology (Clifton, N.J.) 2002;178():379-87.
2001: Duyndam M C; Hulscher T M; Fontijn D; Pinedo H M; Boven E
Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite.
The Journal of biological chemistry 2001;276(51):48066-76.
2001: Pinedo H M
Advances in the use of angiogenesis inhibitors in cancer.
Cancer journal (Sudbury, Mass.) 2001;7 Suppl 3():S107-8.
2001: Ferreira C G; van der Valk P; Span S W; Ludwig I; Smit E F; Kruyt F A; Pinedo H M; van Tinteren H; Giaccone G
Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2468-74.
2001: van der Vliet H J; von Blomberg B M; Nishi N; Reijm M; Voskuyl A E; van Bodegraven A A; Polman C H; Rustemeyer T; Lips P; van den Eertwegh A J; Giaccone G; Scheper R J; Pinedo H M
Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage.
Clinical immunology (Orlando, Fla.) 2001;100(2):144-8.
2001: Backus H H; van Riel J M; van Groeningen C J; Vos W; Dukers D F; Bloemena E; Wouters D; Pinedo H M; Peters G J
Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(6):779-85.
2001: de Graaf M; van Veen I C; van der Meulen-Muileman I H; Gerritsen W R; Pinedo H M; Haisma H J
Cloning and characterization of human liver cytosolic beta-glycosidase.
The Biochemical journal 2001;356(Pt 3):907-10.
2001: Bergman A M; Munch-Petersen B; Jensen P B; Sehested M; Veerman G; Voorn D A; Smid K; Pinedo H M; Peters G J
Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
Biochemical pharmacology 2001;61(11):1401-8.
2001: Heideman D A; Snijders P J; Craanen M E; Bloemena E; Meijer C J; Meuwissen S G; van Beusechem V W; Pinedo H M; Curiel D T; Haisma H J; Gerritsen W R
Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors.
Cancer gene therapy 2001;8(5):342-51.
2001: Savonije J H; Spanier B W; van Groeningen C J; Giaccone G; Pinedo H M
[Decline in the need for blood transfusions in cancer patients due to the use of epoietin alfa during cisplatin based chemotherapy]
Nederlands tijdschrift voor geneeskunde 2001;145(18):878-81.
2001: Grill J; Van Beusechem V W; Van Der Valk P; Dirven C M; Leonhart A; Pherai D S; Haisma H J; Pinedo H M; Curiel D T; Gerritsen W R
Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3):641-50.
2001: Bergman A M; Pinedo H M; Peters G J
Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells.
European journal of pharmacology 2001;416(1-2):19-24.
2001: Hanna M G; Hoover H C; Vermorken J B; Harris J E; Pinedo H M
Adjuvant active specific immunotherapy of stage II and stage III colon cancer with an autologous tumor cell vaccine: first randomized phase III trials show promise.
Vaccine 2001;19(17-19):2576-82.
2001: Backus H H; Dukers D F; van Groeningen C J; Vos W; Bloemena E; Wouters D; van Riel J M; Smid K; Giaccone G; Pinedo H M; Peters G J
5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(2):209-16.
2001: Houba P H; Boven E; van der Meulen-Muileman I H; Leenders R G; Scheeren J W; Pinedo H M; Haisma H J
Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.
International journal of cancer. Journal international du cancer 2001;91(4):550-4.
2001: Houba P H; Boven E; van der Meulen-Muileman I H; Leenders R G; Scheeren J W; Pinedo H M; Haisma H J
A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer.
British journal of cancer 2001;84(4):550-7.
2001: Bos R; Zhong H; Hanrahan C F; Mommers E C; Semenza G L; Pinedo H M; Abeloff M D; Simons J W; van Diest P J; van der Wall E
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis.
Journal of the National Cancer Institute 2001;93(4):309-14.
2001: van der Vliet HJ; Nishi N; Koezuka Y; von Blomberg BM; van den Eertwegh AJ; Porcelli S A; Pinedo H M; Scheper R J; Giaccone G
Potent expansion of human natural killer T cells using alpha-galactosylceramide (KRN7000)-loaded monocyte-derived dendritic cells, cultured in the presence of IL-7 and IL-15.
Journal of immunological methods 2001;247(1-2):61-72.
2001: van den Eertwegh A J; Baars A; Pinedo H M
Adjuvant treatment of colorectal cancer: towards tumor-specific immunotherapies.
Cancer metastasis reviews 2001;20(1-2):101-8.
2001: van Hensbergen Y; Luykx-de Bakker S A; Heideman D A; Meijer G A; Pinedo H M; van Diest P J
Rapid stereology based quantitative immunohistochemistry of dendritic cells in lymph nodes: a methodological study.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 2001;22(3):143-9.
2001: Pinedo H M; van Groeningen C J
Emerging new opportunities for patients with hepatic metastases from colorectal cancer or primary hepatocellular cancer.
The oncologist 2001;6(1):12-3.
2000: van Riel J M; van Groeningen C J; Albers S H; Cazemier M; Meijer S; Bleichrodt R; van den Berg F G; Pinedo H M; Giaccone G
Hepatic arterial 5-fluorouracil in patients with liver metastases of colorectal cancer: single-centre experience in 145 patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(12):1563-70.
2000: de Boer F; Dräger A M; Van Haperen M J; van der Wall E; Kessler F; Huijgens P C; Pinedo H M; Schuurhuis G J
The phenotypic profile of CD34-positive peripheral blood stem cells in different mobilization regimens.
British journal of haematology 2000;111(4):1138-44.
2000: Verheul H M; Jorna A S; Hoekman K; Broxterman H J; Gebbink M F; Pinedo H M
Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets.
Blood 2000;96(13):4216-21.
2000: van Moorsel C J; Pinedo H M; Smid K; Comijn E M; Voorn D A; Veerman G; Lakerveld B; Van der Vijgh W J; Giaccone G; Postmus P E; Peters G J
Schedule-dependent pharmacodynamic effects of gemcitabine and cisplatin in mice bearing Lewis lung murine non-small cell lung tumours.
European journal of cancer (Oxford, England : 1990) 2000;36(18):2420-9.
2000: van Beusechem V W; van Rijswijk A L; van Es H H; Haisma H J; Pinedo H M; Gerritsen W R
Recombinant adenovirus vectors with knobless fibers for targeted gene transfer.
Gene therapy 2000;7(22):1940-6.
2000: Pinedo H M; van den Eertwegh A J
Aggressive combination therapy to cure patients with metastatic cancer.
The lancet oncology 2000;1():72-3.
2000: Van Hattum A H; Pinedo H M; Schlüper H M; Hausheer F H; Boven E
New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer.
International journal of cancer. Journal international du cancer 2000;88(2):260-6.
2000: Bergman A M; Giaccone G; van Moorsel C J; Mauritz R; Noordhuis P; Pinedo H M; Peters G J
Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
European journal of cancer (Oxford, England : 1990) 2000;36(15):1974-83.
2000: Kroep J R; Giaccone G; Tolis C; Voorn D A; Loves W J; Groeningen C J; Pinedo H M; Peters G J
Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines.
British journal of cancer 2000;83(8):1069-76.
2000: Kolfschoten G M; Hulscher T M; Pinedo H M; Boven E
Drug resistance features and S-phase fraction as possible determinants for drug response in a panel of human ovarian cancer xenografts.
British journal of cancer 2000;83(7):921-7.
2000: Verheul H M; Pinedo H M
The role of vascular endothelial growth factor (VEGF) in tumor angiogenesis and early clinical development of VEGF-receptor kinase inhibitors.
Clinical breast cancer 2000;1 Suppl 1():S80-4.
2000: van den Eertwegh A J; Pinedo H M
New developments in autologous tumor cell vaccination therapy for renal cell carcinoma.
Current oncology reports 2000;2(5):369-71.
2000: Backus H H; Pinedo H M; Wouters D; Padrón J M; Molders N; van Der Wilt C L; van Groeningen C J; Jansen G; Peters G J
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
International journal of cancer. Journal international du cancer 2000;87(6):771-8.
2000: Baars A; Claessen A M; van den Eertwegh A J; Gall H E; Stam A G; Meijer S; Giaccone G; Meijer C J; Scheper R J; Wagstaff J; Vermorken J B; Pinedo H M
Skin tests predict survival after autologous tumor cell vaccination in metastatic melanoma: experience in 81 patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(8):965-70.
2000: van Riel J M; van Groeningen C J; Giaccone G; Pinedo H M
Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver.
Oncology 2000;59(2):89-97.
2000: van Groeningen C J; Peters G J; Schornagel J H; Gall H; Noordhuis P; de Vries M J; Turner S L; Swart M S; Pinedo H M; Hanauske A R; Giaccone G
Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(14):2772-9.
2000: Haisma H J; Grill J; Curiel D T; Hoogeland S; van Beusechem V W; Pinedo H M; Gerritsen W R
Targeting of adenoviral vectors through a bispecific single-chain antibody.
Cancer gene therapy 2000;7(6):901-4.
2000: Broxterman H J; Sonneveld P; van Putten W J; Lankelma J; Eekman C A; Ossenkoppele G J; Pinedo H M; Löwenberg B; Schuurhuis G J
P-glycoprotein in primary acute myeloid leukemia and treatment outcome of idarubicin/cytosine arabinoside-based induction therapy.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(6):1018-24.
2000: Van Triest B; Loftus B M; Pinedo H M; Backus H H; Schoenmakers P; Telleman F; Tadema T; Aherne G W; Van Groeningen C J; Zoetmulder F A; Taal B G; Johnston P G; Peters G J
Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(6):755-60.
2000: Pinedo H M
New development of treatment for locally advanced breast cancer.
Gan to kagaku ryoho. Cancer & chemotherapy 2000;27 Suppl 2():272-3.
2000: Peters G J; van Triest B; Backus H H; Kuiper C M; van der Wilt C L; Pinedo H M
Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
European journal of cancer (Oxford, England : 1990) 2000;36(7):916-24.
2000: Van Triest B; Pinedo H M; Giaccone G; Peters G J
Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(4):385-91.
2000: van Groeningen C J; Van der Vijgh W J; Baars J J; Stieltjes H; Huibregtse K; Pinedo H M
Altered pharmacokinetics and metabolism of CPT-11 in liver dysfunction: a need for guidelines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1342-6.
2000: van Der Vliet H J; Nishi N; de Gruijl T D; von Blomberg B M; van den Eertwegh A J; Pinedo H M; Giaccone G; Scheper R J
Human natural killer T cells acquire a memory-activated phenotype before birth.
Blood 2000;95(7):2440-2.
2000: Nishi N; van der Vliet H J; Koezuka Y; von Blomberg B M; Scheper R J; Pinedo H M; Giaccone G
Synergistic effect of KRN7000 with interleukin-15, -7, and -2 on the expansion of human V alpha 24+V beta 11+ T cells in vitro.
Human immunology 2000;61(4):357-65.
2000: van Triest B; Pinedo H M; Blaauwgeers J L; van Diest P J; Schoenmakers P S; Voorn D A; Smid K; Hoekman K; Hoitsma H F; Peters G J
Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1063-72.
2000: Hooijberg J H; Pinedo H M; Vrasdonk C; Priebe W; Lankelma J; Broxterman H J
The effect of glutathione on the ATPase activity of MRP1 in its natural membranes.
FEBS letters 2000;469(1):47-51.
2000: van Moorsel C J; Bergman A M; Veerman G; Voorn D A; Ruiz van Haperen V W; Kroep J R; Pinedo H M; Peters G J
Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines.
Biochimica et biophysica acta 2000;1474(1):5-12.
2000: Kolfschoten G M; Pinedo H M; Scheffer P G; Schlüper H M; Erkelens C A; Boven E
Development of a panel of 15 human ovarian cancer xenografts for drug screening and determination of the role of the glutathione detoxification system.
Gynecologic oncology 2000;76(3):362-8.
2000: Bom J B; Verheul H M; Hoekman K; Pinedo H M
[Coagulation disorders in cancer patients: possible opportunity for therapy]
Nederlands tijdschrift voor geneeskunde 2000;144(6):258-63.
2000: Giaccone G; Smit E F; van Meerbeeck J P; Splinter T; Golding R P; Pinedo H M; Laan D; van Tinteren H; Postmus P E
A phase I-II study of gemcitabine and paclitaxel in advanced non-small-cell lung cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(1):109-12.
2000: Ferreira C G; Tolis C; Span S W; Peters G J; van Lopik T; Kummer A J; Pinedo H M; Giaccone G
Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):203-12.
2000: Verheul H M; Hoekman K; Lupu F; Broxterman H J; van der Valk P; Kakkar A K; Pinedo H M
Platelet and coagulation activation with vascular endothelial growth factor generation in soft tissue sarcomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):166-71.
2000: Lankelma J; Fernández Luque R; Dekker H; Schinkel W; Pinedo H M
A mathematical model of drug transport in human breast cancer.
Microvascular research 2000;59(1):149-61.
2000: Backus H H; Wouters D; van der Wilt C L; Kuiper C M; van Groeningen C J; Pinedo H M; Peters G J
Thymidylate synthase inhibition induces p53 dependent and independent cell death.
Advances in experimental medicine and biology 2000;486():303-6.
2000: Peters G J; De Bruin M; Fukushima M; Van Triest B; Hoekman K; Pinedo H M; Ackland S P
Thymidine phosphorylase in angiogenesis and drug resistance. Homology with platelet-derived endothelial cell growth factor.
Advances in experimental medicine and biology 2000;486():291-4.
2000: van der Wilt C L; Kroep J R; Bergman A M; Loves W J; Alvarez E; Talianidis I; Eriksson S; van Groeningen C J; Pinedo H M; Peters G J
The role of deoxycytidine kinase in gemcitabine cytotoxicity.
Advances in experimental medicine and biology 2000;486():287-90.
2000: Backus H H; Pinedo H M; Wouters D; Kuiper C M; Jansen G; van Groeningen C J; Peters G J
Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates.
Oncology research 2000;12(5):231-9.
2000: Boven E; Van Hattum A H; Hoogsteen I; Schlüper H M; Pinedo H M
New analogues of camptothecins. Activity and resistance.
Annals of the New York Academy of Sciences 2000;922():175-7.
2000: Pinedo H M; de Gruijl T D; van Der Wall E; Buter J
Biological concepts of prolonged neoadjuvant treatment plus GM-CSF in locally advanced tumors.
The oncologist 2000;5(6):497-500.
2000: Verheul H M; Hoekman K; Jorna A S; Smit E F; Pinedo H M
Targeting vascular endothelial growth factor blockade: ascites and pleural effusion formation.
The oncologist 2000;5 Suppl 1():45-50.
1999: Kroep J R; Peters G J; van Moorsel C J; Catik A; Vermorken J B; Pinedo H M; van Groeningen C J
Gemcitabine-cisplatin: a schedule finding study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(12):1503-10.
1999: Van Der Vliet H J; Nishi N; Koezuka Y; Peyrat M A; Von Blomberg B M; Van Den Eertwegh A J; Pinedo H M; Giaccone G; Scheper R J
Effects of alpha-galactosylceramide (KRN7000), interleukin-12 and interleukin-7 on phenotype and cytokine profile of human Valpha24+ Vbeta11+ T cells.
Immunology 1999;98(4):557-63.
1999: Jansen G; Peters G J; Pinedo H M; Priest D G; Assaraf Y G
Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
Journal of the National Cancer Institute 1999;91(23):2047-50.
1999: Peters G J; Smitskamp-Wilms E; Smid K; Pinedo H M; Jansen G
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Cancer research 1999;59(21):5529-35.
1999: Verheul H M; Panigrahy D; Flynn E; Pinedo H M; D'Amato R J
Treatment of the Kasabach-Merritt syndrome with pegylated recombinant human megakaryocyte growth and development factor in mice: elevated platelet counts, prolonged survival, and tumor growth inhibition.
Pediatric research 1999;46(5):562-5.
1999: Hooijberg J H; Broxterman H J; Scheffer G L; Vrasdonk C; Heijn M; de Jong M C; Scheper R J; Lankelma J; Pinedo H M
Potent interaction of flavopiridol with MRP1.
British journal of cancer 1999;81(2):269-76.
1999: Hoekman K; van Doorn J; Gloudemans T; Maassen J A; Schuller A G; Pinedo H M
Hypoglycaemia associated with the production of insulin-like growth factor II and insulin-like growth factor binding protein 6 by a haemangiopericytoma.
Clinical endocrinology 1999;51(2):247-53.
1999: Haisma H J; Pinedo H M; Rijswijk A; der Meulen-Muileman I; Sosnowski B A; Ying W; Beusechem V W; Tillman B W; Gerritsen W R; Curiel D T
Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM.
Gene therapy 1999;6(8):1469-74.
1999: Lobbezoo M W; Krul M R; Pinedo H M
Discovery of new anti-cancer agents.
Forum (Genoa, Italy) 1999;9(3 Suppl 3):47-53.
1999: Kroep J R; Giaccone G; Voorn D A; Smit E F; Beijnen J H; Rosing H; van Moorsel C J; van Groeningen C J; Postmus P E; Pinedo H M; Peters G J
Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(7):2190-7.
1999: Verheul H M; Bom J B; Hoekman K; Pinedo H M
[Inhibition of tumor angiogenesis as a cancer treatment]
Nederlands tijdschrift voor geneeskunde 1999;143(30):1549-55.
1999: Pinedo H M; van Groeningen C J
[National cancer fund (Koningin Wilhelmina Fonds) justifiably calls for continued focus on the cancer problem in Netherlands]
Nederlands tijdschrift voor geneeskunde 1999;143(29):1499-502.
1999: Lankelma J; Dekker H; Luque F R; Luykx S; Hoekman K; van der Valk P; van Diest P J; Pinedo H M
Doxorubicin gradients in human breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1703-7.
1999: Hooijberg J H; Broxterman H J; Kool M; Assaraf Y G; Peters G J; Noordhuis P; Scheper R J; Borst P; Pinedo H M; Jansen G
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
Cancer research 1999;59(11):2532-5.
1999: van Moorsel C J; Pinedo H M; Veerman G; Bergman A M; Kuiper C M; Vermorken J B; van der Vijgh W J; Peters G J
Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines.
British journal of cancer 1999;80(7):981-90.
1999: Tillman B W; de Gruijl T D; Luykx-de Bakker S A; Scheper R J; Pinedo H M; Curiel T J; Gerritsen W R; Curiel D T
Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6378-83.
1999: van Moorsel C J; Pinedo H M; Veerman G; Vermorken J B; Postmus P E; Peters G J
Scheduling of gemcitabine and cisplatin in Lewis lung tumour bearing mice.
European journal of cancer (Oxford, England : 1990) 1999;35(5):808-14.
1999: Tolis C; Peters G J; Ferreira C G; Pinedo H M; Giaccone G
Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines.
European journal of cancer (Oxford, England : 1990) 1999;35(5):796-807.
1999: van Moorsel C J; Kroep J R; Pinedo H M; Veerman G; Voorn D A; Postmus P E; Vermorken J B; van Groeningen C J; van der Vijgh W J; Peters G J
Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(4):441-8.
1999: Sikora K; Advani S; Koroltchouk V; Magrath I; Levy L; Pinedo H; Schwartsmann G; Tattersall M; Yan S
Essential drugs for cancer therapy: a World Health Organization consultation.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(4):385-90.
1999: van Triest B; Pinedo H M; van Hensbergen Y; Smid K; Telleman F; Schoenmakers P S; van der Wilt C L; van Laar J A; Noordhuis P; Jansen G; Peters G J
Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):643-54.
1999: Houba P H; Boven E; van der Meulen-Muileman I H; Leenders R G; Scheeren J W; Pinedo H M; Haisma H J
Distribution and pharmacokinetics of the prodrug daunorubicin-GA3 in nude mice bearing human ovarian cancer xenografts.
Biochemical pharmacology 1999;57(6):673-80.
1999: Luykx-de Bakker S A; Verheul H M; de Gruijl T D; Pinedo H M
Prolonged neoadjuvant treatment in locally advanced tumours: a novel concept based on biological considerations.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(2):155-60.
1999: Broxterman H J; Sonneveld P; Pieters R; Lankelma J; Eekman C A; Loonen A H; Schoester M; Ossenkoppele G J; Löwenberg B; Pinedo H M; Schuurhuis G J
Do P-glycoprotein and major vault protein (MVP/LRP) expression correlate with in vitro daunorubicin resistance in acute myeloid leukemia?
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(2):258-65.
1999: van Moorsel C J; Pinedo H M; Veerman G; Guechev A; Smid K; Loves W J; Vermorken J B; Postmus P E; Peters G J
Combination chemotherapy studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines.
Biochemical pharmacology 1999;57(4):407-15.
1999: Bergman A M; Pinedo H M; Jongsma A P; Brouwer M; Ruiz van Haperen V W; Veerman G; Leyva A; Eriksson S; Peters G J
Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
Biochemical pharmacology 1999;57(4):397-406.
1999: Luykx-de Bakker S A; de Gruijl T D; Scheper R J; Wagstaff J; Pinedo H M
Dendritic cells: a novel therapeutic modality.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(1):21-7.
1999: Vermorken J B; Claessen A M; van Tinteren H; Gall H E; Ezinga R; Meijer S; Scheper R J; Meijer C J; Bloemena E; Ransom J H; Hanna M G; Pinedo H M
Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial.
Lancet 1999;353(9150):345-50.
1999: van Riel J M; Giaccone G; Pinedo H M
Pancreaticobiliary cancer: the future aspects of medical oncology.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():296-9.
1999: Kroep J R; Pinedo H M; van Groeningen C J; Peters G J
Experimental drugs and drug combinations in pancreatic cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():234-8.
1999: van Riel J M; van Groeningen C J; Pinedo H M; Giaccone G
Current chemotherapeutic possibilities in pancreaticobiliary cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():157-61.
1999: Honkoop A H; Luykx-de Bakker S A; Hoekman K; Meyer S; Meyer O W; van Groeningen C J; van Diest P J; Boven E; van der Wall E; Giaccone G; Wagstaff J; Pinedo H M
Prolonged neoadjuvant chemotherapy with GM-CSF in locally advanced breast cancer.
The oncologist 1999;4(2):106-11.
1998: De Boer F; Dräger A M; Van der Wall E; Pinedo H M; Schuurhuis G J
Changes in L-selectin expression on CD34-positive cells upon cryopreservation of peripheral blood stem cell transplants.
Bone marrow transplantation 1998;22(11):1103-10.
1998: Houba P H; Boven E; Erkelens C A; Leenders R G; Scheeren J W; Pinedo H M; Haisma H J
The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.
British journal of cancer 1998;78(12):1600-6.
1998: Boven E; Pinedo H M; van Hattum A H; Scheffer P G; Peters W H; Erkelens C A; Schlüper H M; Kuiper C M; van Ark-Otte J; Giaccone G
Characterization of human soft-tissue sarcoma xenografts for use in secondary drug screening.
British journal of cancer 1998;78(12):1586-93.
1998: Pinedo H M; Verheul H M; D'Amato R J; Folkman J
Involvement of platelets in tumour angiogenesis?
Lancet 1998;352(9142):1775-7.
1998: Jansen G; Mauritz R; Drori S; Sprecher H; Kathmann I; Bunni M; Priest D G; Noordhuis P; Schornagel J H; Pinedo H M; Peters G J; Assaraf Y G
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
The Journal of biological chemistry 1998;273(46):30189-98.
1998: Dingemans A M; Pinedo H M; Giaccone G
Clinical resistance to topoisomerase-targeted drugs.
Biochimica et biophysica acta 1998;1400(1-3):275-88.
1998: Haisma H J; Sernee M F; Hooijberg E; Brakenhoff R H; vd Meulen-Muileman I H; Pinedo H M; Boven E
Construction and characterization of a fusion protein of single-chain anti-CD20 antibody and human beta-glucuronidase for antibody-directed enzyme prodrug therapy.
Blood 1998;92(1):184-90.
1998: van Ark-Otte J; Kedde M A; van der Vijgh W J; Dingemans A M; Jansen W J; Pinedo H M; Boven E; Giaccone G
Determinants of CPT-11 and SN-38 activities in human lung cancer cells.
British journal of cancer 1998;77(12):2171-6.
1998: Smitskamp-Wilms E; Pinedo H M; Veerman G; Ruiz van Haperen V W; Peters G J
Postconfluent multilayered cell line cultures for selective screening of gemcitabine.
European journal of cancer (Oxford, England : 1990) 1998;34(6):921-6.
1998: Honkoop A H; Wagstaff J; Pinedo H M
Management of stage III breast cancer.
Oncology 1998;55(3):218-27.
1998: Abrahams P J; Houweling A; Cornelissen-Steijger P D; Jaspers N G; Darroudi F; Meijers C M; Mullenders L H; Filon R; Arwert F; Pinedo H M; Natarajan A P; Terleth C; Van Zeeland A A; van der Eb A J
Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes.
Mutation research 1998;407(2):189-201.
1998: Honkoop A H; van Diest P J; de Jong J S; Linn S C; Giaccone G; Hoekman K; Wagstaff J; Pinedo H M
Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer.
British journal of cancer 1998;77(4):621-6.
1998: Kievit E; van Gog F B; Schlüper H M; van Dongen G A; Pinedo H M; Boven E
[186Re]-labeled mouse and chimeric monoclonal antibody 323/A3: a comparison of the efficacy in experimental human ovarian cancer.
Nuclear medicine and biology 1998;25(1):37-45.
1998: van Ark-Otte J; Samelis G; Rubio G; Lopez Saez J B; Pinedo H M; Giaccone G
Effects of tubulin-inhibiting agents in human lung and breast cancer cell lines with different multidrug resistance phenotypes.
Oncology reports 1998;5(1):249-55.
1998: Haisma H J; Brakenhoff R H; vd Meulen-Muileman I; Pinedo H M; Boven E
Construction and characterization of a fusion protein of single-chain anti-carcinoma antibody 323/A3 and human beta-glucuronidase.
Cancer immunology, immunotherapy : CII 1998;45(5):266-72.
1998: Pinedo H M
European drug development and its impact on national activities: the Dutch example.
Cancer chemotherapy and pharmacology 1998;42 Suppl():S98-101.
1998: Peters G J; Kuiper C M; van Triest B; Backus H; van der Wilt C L; van Laar J A; Jansen G; van Groeningen C J; Pinedo H M
Determinants of the therapeutic efficacy of thymidylate synthase inhibitors.
Advances in experimental medicine and biology 1998;431():699-704.
1998: Kroep J R; van Moorsel C J; Veerman G; Voorn D A; Schultz R M; Worzalla J F; Tanzer L R; Merriman R L; Pinedo H M; Peters G J
Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC).
Advances in experimental medicine and biology 1998;431():657-60.
1998: Peters G J; van Groeningen C J; Pinedo H M
Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil.
Advances in experimental medicine and biology 1998;431():633-6.
1998: Bergman A M; Pinedo H M; Veerman G; Kuiper C M; Peters G J
Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines.
Advances in experimental medicine and biology 1998;431():591-4.
1998: Bergman A M; Pinedo H M; Ruiz van Haperen V W; Veerman G; Kuiper C M; Peters G J
Cross-resistance of the gemcitabine resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
Advances in experimental medicine and biology 1998;431():587-90.
1998: van Moorsel C J; Veerman G; Vermorken J B; Voorn D A; Kroep J R; Bergman A M; Pinedo H M; Peters G J
Mechanisms of synergism between gemcitabine and cisplatin.
Advances in experimental medicine and biology 1998;431():581-5.
1998: Jansen W J; Hulscher T M; van Ark-Otte J; Giaccone G; Pinedo H M; Boven E
CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug resistance-associated protein.
British journal of cancer 1998;77(3):359-65.
1997: Verheul H M; Hoekman K; Luykx-de Bakker S; Eekman C A; Folman C C; Broxterman H J; Pinedo H M
Platelet: transporter of vascular endothelial growth factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 1):2187-90.
1997: Pinedo H
Future perspectives.
Seminars in oncology 1997;24(6 Suppl 19):S19-112-S19-113.
1997: Jansen W J; Kolfschoten G M; Erkelens C A; Van Ark-Otte J; Pinedo H M; Boven E
Anti-tumor activity of CPT-11 in experimental human ovarian cancer and human soft-tissue sarcoma.
International journal of cancer. Journal international du cancer 1997;73(6):891-6.
1997: Giaccone G; Linn S C; Welink J; Catimel G; Stieltjes H; van der Vijgh W J; Eeltink C; Vermorken J B; Pinedo H M
A dose-finding and pharmacokinetic study of reversal of multidrug resistance with SDZ PSC 833 in combination with doxorubicin in patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2005-15.
1997: Hoekman K; van Holten-Verzantvoort A T; Pinedo H M
[Bisphosphonates in the treatment and prevention of bone metastases]
Nederlands tijdschrift voor geneeskunde 1997;141(46):2217-22.
1997: Honkoop A H; van der Wall E; Feller N; Schuurhuis G J; van der Vijgh W J; Boven E; van Groeningen C J; Giaccone G; Hoekman K; Vermorken J B; Wagstaff J; Pinedo H M
Multiple cycles of high-dose doxorubicin and cyclophosphamide with G-CSF mobilized peripheral blood progenitor cell support in patients with metastatic breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1997;8(10):957-62.
1997: Hooijberg J H; Broxterman H J; Heijn M; Fles D L; Lankelma J; Pinedo H M
Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein.
FEBS letters 1997;413(2):344-8.
1997: Kievit E; van Gog F B; Schlüper H M; van Dongen G A; Pinedo H M; Boven E
Comparison of the biodistribution and the efficacy of monoclonal antibody 323/A3 labeled with either 131I or 186Re in human ovarian cancer xenografts.
International journal of radiation oncology, biology, physics 1997;38(4):813-23.
1997: Broxterman H J; Lankelma J; Pinedo H M; Eekman C A; Währer D C; Ossenkoppele G J; Schuurhuis G J
Theoretical and practical considerations for the measurement of P-glycoprotein function in acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(7):1110-8.
1997: van Triest B; Pinedo H M; Telleman F; van der Wilt C L; Jansen G; Peters G J
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
Biochemical pharmacology 1997;53(12):1855-66.
1997: Apolinario R M; van der Valk P; de Jong J S; Deville W; van Ark-Otte J; Dingemans A M; van Mourik J C; Postmus P E; Pinedo H M; Giaccone G
Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(6):2456-66.
1997: Kievit E; Pinedo H M; Schlüper H M; Boven E
Addition of cisplatin improves efficacy of 131I-labeled monoclonal antibody 323/A3 in experimental human ovarian cancer.
International journal of radiation oncology, biology, physics 1997;38(2):419-28.
1997: Linn S C; Pinedo H M; van Ark-Otte J; van der Valk P; Hoekman K; Honkoop A H; Vermorken J B; Giaccone G
Expression of drug resistance proteins in breast cancer, in relation to chemotherapy.
International journal of cancer. Journal international du cancer 1997;71(5):787-95.
1997: Pinedo H M; Giaccone G
Chemotherapy.
Lancet 1997;349 Suppl 2():SII7-9.
1997: Kievit E; Pinedo H M; Schlüper H M; Haisma H J; Boven E
Determination of tumor-related factors of influence on the uptake of the monoclonal antibody 323/A3 in experimental human ovarian cancer.
International journal of cancer. Journal international du cancer 1997;71(2):237-45.
1997: Feller N; Hoekman K; Kuiper C M; Linn S C; Verheul H M; Wolthers B G; Popp-Snijders C; Pinedo H M
A patient with adrenocortical carcinoma: characterization of its biological activity and drug resistance profile.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):389-94.
1997: Honkoop A H; Pinedo H M; De Jong J S; Verheul H M; Linn S C; Hoekman K; Wagstaff J; van Diest P J
Effects of chemotherapy on pathologic and biologic characteristics of locally advanced breast cancer.
American journal of clinical pathology 1997;107(2):211-8.
1997: Jansen W J; Zwart B; Hulscher S T; Giaccone G; Pinedo H M; Boven E
CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants.
International journal of cancer. Journal international du cancer 1997;70(3):335-40.
1997: Meijs W E; Haisma H J; Klok R P; van Gog F B; Kievit E; Pinedo H M; Herscheid J D
Zirconium-labeled monoclonal antibodies and their distribution in tumor-bearing nude mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(1):112-8.
1997: Huizing M T; Giaccone G; van Warmerdam L J; Rosing H; Bakker P J; Vermorken J B; Postmus P E; van Zandwijk N; Koolen M G; ten Bokkel Huinink W W; van der Vijgh W J; Bierhorst F J; Lai A; Dalesio O; Pinedo H M; Veenhof C H; Beijnen J H
Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(1):317-29.
1997: van der Wilt C L; van Groeningen C J; Pinedo H M; Smid K; Hoekman K; Meijer S; Peters G J
5-fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man.
Journal of cancer research and clinical oncology 1997;123(11-12):595-601.
1997: Jansen G; Mauritz R M; Assaraf Y G; Sprecher H; Drori S; Kathmann I; Westerhof G R; Priest D G; Bunni M; Pinedo H M; Schornagel J H; Peters G J
Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
Advances in enzyme regulation 1997;37():59-76.
1997: Broxterman H J; Schuurhuis G J; Lankelma J; Oberink J W; Eekman C A; Claessen A M; Hoekman K; Poot M; Pinedo H M
Highly sensitive and specific detection of P-glycoprotein function for haematological and solid tumour cells using a novel nucleic acid stain.
British journal of cancer 1997;76(8):1029-34.
1997: Verweij J; Pinedo H M
Adjuvant chemotherapy of soft tissue sarcomas.
Cancer treatment and research 1997;91():173-87.
1996: Honkoop A H; Hoekman K; Wagstaff J; van Groeningen C J; Vermorken J B; Boven E; Pinedo H M
Continuous infusion or subcutaneous injection of granulocyte-macrophage colony-stimulating factor: increased efficacy and reduced toxicity when given subcutaneously.
British journal of cancer 1996;74(7):1132-6.
1996: van Laar J A; van der Wilt C L; Rustum Y M; Noordhuis P; Smid K; Pinedo H M; Peters G J
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(8):1327-33.
1996: Houba P H; Leenders R G; Boven E; Scheeren J W; Pinedo H M; Haisma H J
Characterization of novel anthracycline prodrugs activated by human beta-glucuronidase for use in antibody-directed enzyme prodrug therapy.
Biochemical pharmacology 1996;52(3):455-63.
1996: Linn S C; Honkoop A H; Hoekman K; van der Valk P; Pinedo H M; Giaccone G
p53 and P-glycoprotein are often co-expressed and are associated with poor prognosis in breast cancer.
British journal of cancer 1996;74(1):63-8.
1996: Broxterman H J; Lankelma J; Pinedo H M
How to probe clinical tumour samples for P-glycoprotein and multidrug resistance-associated protein.
European journal of cancer (Oxford, England : 1990) 1996;32A(6):1024-33.
1996: Abrahams P J; Houweling A; Cornelissen-Steijger D M; Arwert F; Menko F H; Pinedo H M; Terleth C; van der Eb A J
Inheritance of abnormal expression of SOS-like response in xeroderma pigmentosum and hereditary cancer-prone syndromes.
Cancer research 1996;56(11):2621-5.
1996: Giaccone G; van Ark-Otte J; Rubio G J; Gazdar A F; Broxterman H J; Dingemans A M; Flens M J; Scheper R J; Pinedo H M
MRP is frequently expressed in human lung-cancer cell lines, in non-small-cell lung cancer and in normal lungs.
International journal of cancer. Journal international du cancer 1996;66(6):760-7.
1996: Broxterman H J; Sonneveld P; Feller N; Ossenkoppele G J; Währer D C; Eekman C A; Schoester M; Lankelma J; Pinedo H M; Löwenberg B; Schuurhuis G J
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity.
Blood 1996;87(11):4809-16.
1996: Meijs W E; Haisma H J; Van der Schors R; Wijbrandts R; Van den Oever K; Klok R P; Pinedo H M; Herscheid J D
A facile method for the labeling of proteins with zirconium isotopes.
Nuclear medicine and biology 1996;23(4):439-48.
1996: van Haperen V W; Veerman G; Vermorken J B; Pinedo H M; Peters G
Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine.
Biochemical pharmacology 1996;51(7):911-8.
1996: Pinedo H M
Drug resistance, illustration of the complexity of translational research. Steiner Award lecture 1995.
International journal of cancer. Journal international du cancer 1996;65(5):561-6.
1996: Kievit E; Pinedo H M; Schlüper H M; Haisma H J; Boven E
Comparison of monoclonal antibodies 17-1A and 323/A3: the influence of the affinity on tumour uptake and efficacy of radioimmunotherapy in human ovarian cancer xenografts.
British journal of cancer 1996;73(4):457-64.
1996: Mülder H S; Pinedo H M; Timmer A T; Rao B R; Lankelma J
Multidrug resistance-modifying components in human plasma with potential clinical significance.
Journal of experimental therapeutics & oncology 1996;1(1):13-22.
1996: Honkoop A H; Hoekman K; Wagstaff J; Boven E; van Groeningen C J; Giaccone G; Vermorken J B; Pinedo H M
Dose-intensive chemotherapy with doxorubicin, cyclophosphamide and GM-CSF fails to improve survival of metastatic breast cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7(1):35-9.
1996: Van Laar J A; Rustum Y M; Van der Wilt C L; Smid K; Kuiper C M; Pinedo H M; Peters G J
Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas.
Cancer chemotherapy and pharmacology 1996;39(1-2):79-89.
1996: Veerman G; Ruiz van Haperen V W; Vermorken J B; Noordhuis P; Braakhuis B J; Pinedo H M; Peters G J
Antitumor activity of prolonged as compared with bolus administration of 2',2'-difluorodeoxycytidine in vivo against murine colon tumors.
Cancer chemotherapy and pharmacology 1996;38(4):335-42.
1996: Pinedo H M; Longo D L; Chabner B A
Cancer chemotherapy and biological response modifiers annual 16. Introduction.
Cancer chemotherapy and biological response modifiers 1996;16():xvii-xviii.
1995: Huizing M T; Sparreboom A; Rosing H; van Tellingen O; Pinedo H M; Beijnen J H
Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1995;674(2):261-8.
1995: Boven E; Haisma H J; Pinedo H M
[Monoclonal antibodies for diagnosis and therapy in oncological patients]
Nederlands tijdschrift voor geneeskunde 1995;139(49):2552-8.
1995: Jansen W J; Pinedo H M; van der Wilt C L; Feller N; Bamberger U; Boven E
The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts.
European journal of cancer (Oxford, England : 1990) 1995;31A(13-14):2313-9.
1995: Dercksen M W; Weimar I S; Richel D J; Breton-Gorius J; Vainchenker W; Slaper-Cortenbach C M; Pinedo H M; von dem Borne A E; Gerritsen W R; van der Schoot C E
The value of flow cytometric analysis of platelet glycoprotein expression of CD34+ cells measured under conditions that prevent P-selectin-mediated binding of platelets.
Blood 1995;86(10):3771-82.
1995: Pinedo H M; Giaccone G
P-glycoprotein--a marker of cancer-cell behavior.
The New England journal of medicine 1995;333(21):1417-9.
1995: Peters G J; Noordhuis P; Komissarov A; Holwerda U; Kok M; Van Laar J A; Van der Wilt C L; Van Groeningen V; Pinedo H M
Quantification of 5-fluorouracil incorporation into RNA of human and murine tumors as measured with a sensitive gas chromatography-mass spectrometry assay.
Analytical biochemistry 1995;231(1):157-63.
1995: Smitskamp-Wilms E; Giaccone G; Pinedo H M; van der Laan B F; Peters G J
DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
British journal of cancer 1995;72(4):917-21.
1995: Huizing M T; Vermorken J B; Rosing H; ten Bokkel Huinink W W; Mandjes I; Pinedo H M; Beijnen J H
Pharmacokinetics of paclitaxel and three major metabolites in patients with advanced breast carcinoma refractory to anthracycline therapy treated with a 3-hour paclitaxel infusion: a European Cancer Centre (ECC) trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(7):699-704.
1995: Linn S C; Giaccone G; van Diest P J; Blokhuis W M; van der Valk P; van Kalken C K; Kuiper C M; Pinedo H M; Baak J P
Prognostic relevance of P-glycoprotein expression in breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(7):679-85.
1995: Feller N; Kuiper C M; Lankelma J; Ruhdal J K; Scheper R J; Pinedo H M; Broxterman H J
Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry.
British journal of cancer 1995;72(3):543-9.
1995: Westerhof G R; Rijnboutt S; Schornagel J H; Pinedo H M; Peters G J; Jansen G
Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
Cancer research 1995;55(17):3795-802.
1995: Mülder H S; Dekker H; Pinedo H M; Lankelma J
The P-glycoprotein-mediated relative decrease in cytosolic free drug concentration is similar for several anthracyclines with varying lipophilicity.
Biochemical pharmacology 1995;50(7):967-74.
1995: Westerhof G R; Schornagel J H; Kathmann I; Jackman A L; Rosowsky A; Forsch R A; Hynes J B; Boyle F T; Peters G J; Pinedo H M
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
Molecular pharmacology 1995;48(3):459-71.
1995: Haisma H J; Van Muijen M; Scheffer G; Scheper R J; Pinedo H M; Boven E
A monoclonal antibody against human beta-glucuronidase for application in antibody-directed enzyme prodrug therapy.
Hybridoma 1995;14(4):377-82.
1995: Izquierdo M A; van der Zee A G; Vermorken J B; van der Valk P; Beliën J A; Giaccone G; Scheffer G L; Flens M J; Pinedo H M; Kenemans P
Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma.
Journal of the National Cancer Institute 1995;87(16):1230-7.
1995: Giaccone G; Huizing M; Postmus P E; ten Bokkel Huinink W W; Koolen M; van Zandwijk N; Vermorken J B; Beijnen J H; Dalesio O; Pinedo H M
Dose-finding and sequencing study of paclitaxel and carboplatin in non-small cell lung cancer.
Seminars in oncology 1995;22(4 Suppl 9):78-82.
1995: Vermorken J B; ten Bokkel Huinink W W; Mandjes I A; Postma T J; Huizing M T; Heimans J J; Beijnen J H; Bierhorst F; Winograd B; Pinedo H M
High-dose paclitaxel with granulocyte colony-stimulating factor in patients with advanced breast cancer refractory to anthracycline therapy: a European Cancer Center trial.
Seminars in oncology 1995;22(4 Suppl 8):16-22.
1995: Dercksen M W; Rodenhuis S; Dirkson M K; Schaasberg W P; Baars J W; van der Wall E; Slaper-Cortenbach I C; Pinedo H M; Von dem Borne A E; van der Schoot C E
Subsets of CD34+ cells and rapid hematopoietic recovery after peripheral-blood stem-cell transplantation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(8):1922-32.
1995: Feller N; Broxterman H J; Währer D C; Pinedo H M
ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion.
FEBS letters 1995;368(2):385-8.
1995: Peters G J; van der Wilt C L; van Triest B; Codacci-Pisanelli G; Johnston P G; van Groeningen C J; Pinedo H M
Thymidylate synthase and drug resistance.
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1299-305.
1995: van Triest B; van Groeningen C J; Pinedo H M
Current chemotherapeutic possibilities in the treatment of colorectal cancer.
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1193-7.
1995: Broxterman H J; Feller N; Kuiper C M; Boven E; Versantvoort C H; Teerlink T; Pinedo H M; Lankelma J
Correlation between functional and molecular analysis of mdr1 P-glycoprotein in human solid-tumor xenografts.
International journal of cancer. Journal international du cancer 1995;61(6):880-6.
1995: ten Bokkel Huinink W; Veenhof C; Helmerhorst T; Bierhorst F; Dalesio O; Winograd B; Depauw L; Pinedo H M
Paclitaxel plus carboplatin in the treatment of ovarian cancer.
Seminars in oncology 1995;22(3 Suppl 6):97-100.
1995: Scheffer G L; Wijngaard P L; Flens M J; Izquierdo M A; Slovak M L; Pinedo H M; Meijer C J; Clevers H C; Scheper R J
The drug resistance-related protein LRP is the human major vault protein.
Nature medicine 1995;1(6):578-82.
1995: Dercksen M W; Gerritsen W R; Rodenhuis S; Dirkson M K; Slaper-Cortenbach I C; Schaasberg W P; Pinedo H M; von dem Borne A E; van der Schoot C E
Expression of adhesion molecules on CD34+ cells: CD34+ L-selectin+ cells predict a rapid platelet recovery after peripheral blood stem cell transplantation.
Blood 1995;85(11):3313-9.
1995: Van der Wilt C L; Braakhuis B J; Pinedo H M; De Jong M; Smid K; Peters G J
Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect?
International journal of cancer. Journal international du cancer 1995;61(5):672-8.
1995: Postma T J; Vermorken J B; Liefting A J; Pinedo H M; Heimans J J
Paclitaxel-induced neuropathy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(5):489-94.
1995: Hoekman K; Huijskes R V; Burger C W; Verheijen R H; Pinedo H M; Vermorken J B
[Favorable results of paclitaxel (Taxol) in patients with ovary carcinoma pretreated with platinum]
Nederlands tijdschrift voor geneeskunde 1995;139(6):272-8.
1995: Dercksen M W; Hoekman K; Visser J J; ten Bokkel Huinink W W; Pinedo H M; Wagstaff J
Hypotension induced by interleukin-3 in patients on angiotensin-converting enzyme inhibitors.
Lancet 1995;345(8947):448.
1995: Huizing M T; Rosing H; Koopman F; Keung A C; Pinedo H M; Beijnen J H
High-performance liquid chromatographic procedures for the quantitative determination of paclitaxel (Taxol) in human urine.
Journal of chromatography. B, Biomedical applications 1995;664(2):373-82.
1995: Giaccone G; Linn S C; Pinedo H M
Multidrug resistance in breast cancer: mechanisms, strategies.
European journal of cancer (Oxford, England : 1990) 1995;31A Suppl 7():S15-7.
1995: van der Wilt C L; Cloos J; de Jong M; Pinedo H M; Peters G J
Screening of colon tumor cells and tissues for folylpolyglutamate synthetase activity.
Oncology research 1995;7(6):317-21.
1995: Rubio G J; Pinedo H M; Virizuela J; van Ark-Otte J; Giaccone G
Effects of suramin on human lung cancer cell lines.
European journal of cancer (Oxford, England : 1990) 1995;31A(2):244-51.
1995: van der Wilt C L; Marinelli A; Pinedo H M; Cloos J; Smid K; van de Velde C J; Peters G J
The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat.
European journal of cancer (Oxford, England : 1990) 1995;31A(5):754-60.
1995: Huizing M T; Misser V H; Pieters R C; ten Bokkel Huinink W W; Veenhof C H; Vermorken J B; Pinedo H M; Beijnen J H
Taxanes: a new class of antitumor agents.
Cancer investigation 1995;13(4):381-404.
1995: Codacci-Pisanelli G; van der Wilt C L; Pinedo H M; Franchi F; Noordhuis P; Braakhuis B J; van Laar J A; Peters G J
Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice.
European journal of cancer (Oxford, England : 1990) 1995;31A(9):1517-25.
1994: Baars J W; Wolbink G J; Hart M H; Hack C E; Eerenberg-Belmer A J; Pinedo H M; Wagstaff J
The release of interleukin-8 during intravenous bolus treatment with interleukin-2.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(10):929-34.
1994: Beijnen J H; Huizing M T; ten Bokkel Huinink W W; Veenhof C H; Vermorken J B; Giaccone G; Pinedo H M
Bioanalysis, pharmacokinetics, and pharmacodynamics of the novel anticancer drug paclitaxel (Taxol).
Seminars in oncology 1994;21(5 Suppl 8):53-62.
1994: Peters G J; van der Wilt C L; van Groeningen C J; Smid K; Meijer S; Pinedo H M
Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(10):2035-42.
1994: Mülder H S; Lankelma J; Dekker H; Broxterman H J; Pinedo H M
Daunorubicin efflux against a concentration gradient in non-P-glycoprotein multidrug-resistant lung-cancer cells.
International journal of cancer. Journal international du cancer 1994;59(2):275-81.
1994: Jansen W J; Pinedo H M; Kuiper C M; Lincke C; Bamberger U; Heckel A; Boven E
Biochemical modulation of 'classical' multidrug resistance by BIBW22BS, a potent derivative of dipyridamole.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(8):733-9.
1994: Pinedo H M; Van Groeningen C J
Vinorelbine: a horse of a different color?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(9):1745-7.
1994: Pizao P E; Smitskamp-Wilms E; Van Ark-Otte J; Beijnen J H; Peters G J; Pinedo H M; Giaccone G
Antiproliferative activity of the topoisomerase I inhibitors topotecan and camptothecin, on sub- and postconfluent tumor cell cultures.
Biochemical pharmacology 1994;48(6):1145-54.
1994: Versantvoort C H; Broxterman H J; Lankelma J; Feller N; Pinedo H M
Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells.
Biochemical pharmacology 1994;48(6):1129-36.
1994: Zaman G J; Flens M J; van Leusden M R; de Haas M; Mülder H S; Lankelma J; Pinedo H M; Scheper R J; Baas F; Broxterman H J
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):8822-6.
1994: Ruiz van Haperen V W; Veerman G; Eriksson S; Boven E; Stegmann A P; Hermsen M; Vermorken J B; Pinedo H M; Peters G J
Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780.
Cancer research 1994;54(15):4138-43.
1994: Lopez-Lopez R; Langeveld C H; Pizao P E; van Rijswijk R E; Wagstaff J; Pinedo H M; Peters G J
Effect of suramin on adenylate cyclase and protein kinase C.
Anti-cancer drug design 1994;9(4):279-90.
1994: Noteborn H P; Varossieau F J; Monshouwer M; Brands R; Pinedo H M
A reversed-phase high-performance liquid chromatographic method for the determination of Clanfenur in rat and human plasma.
Journal of pharmaceutical and biomedical analysis 1994;12(7):937-42.
1994: Linn S C; Giaccone G; Pinedo H M
Complete remission of metastatic colorectal cancer: a pitfall in a multidrug resistance reversal trial.
Lancet 1994;343(8913):1648-9.
1994: Hoekman K; Wagstaff J; Vermorken J B; Meijer S; Meijer O W; Pinedo H M
[Primary high-dose chemotherapy with hematopoietic growth factors followed by surgery and radiotherapy in stage III breast carcinoma; a Phase II study in 15 patients]
Nederlands tijdschrift voor geneeskunde 1994;138(21):1069-73.
1994: van Leeuwen F E; Chorus A M; van den Belt-Dusebout A W; Hagenbeek A; Noyon R; van Kerkhoff E H; Pinedo H M; Somers R
Leukemia risk following Hodgkin's disease: relation to cumulative dose of alkylating agents, treatment with teniposide combinations, number of episodes of chemotherapy, and bone marrow damage.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(5):1063-73.
1994: Spoelstra E C; Westerhoff H V; Pinedo H M; Dekker H; Lankelma J
The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate.
European journal of biochemistry / FEBS 1994;221(1):363-73.
1994: Linn S C; van Kalken C K; van Tellingen O; van der Valk P; van Groeningen C J; Kuiper C M; Pinedo H M; Giaccone G
Clinical and pharmacologic study of multidrug resistance reversal with vinblastine and bepridil.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(4):812-9.
1994: Smitskamp-Wilms E; Peters G J; Pinedo H M; van Ark-Otte J; Giaccone G
Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression.
Biochemical pharmacology 1994;47(8):1325-32.
1994: Ogilvie A C; Baars J W; Eerenberg A J; Hack C E; Pinedo H M; Thijs L G; Wagstaff J
A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2.
British journal of cancer 1994;69(3):596-8.
1994: Hoekman K; van Doorn J; Gloudemans T; Hoekstra O S; Maassen J A; Vermorken J B; Wagstaff J; Pinedo H M
Tumour-induced hypoglycaemia: a case report.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(3):277-81.
1994: Los G; van Vugt M J; Pinedo H M
Response of peritoneal solid tumours after intraperitoneal chemohyperthermia treatment with cisplatin or carboplatin.
British journal of cancer 1994;69(2):235-41.
1994: Oldenburg J; Begg A C; van Vugt M J; Ruevekamp M; Schornagel J H; Pinedo H M; Los G
Characterization of resistance mechanisms to cis-diamminedichloroplatinum(II) in three sublines of the CC531 colon adenocarcinoma cell line in vitro.
Cancer research 1994;54(2):487-93.
1994: Holdener E E; Clavel M; Sessa C; ten Bokkel Huinink W; Siegenthaler P; Ludwig C; Klepp O; Renard G; Decoster G; Pinedo H M
Phase II trial of anaxirone (TGU) in advanced colorectal cancer: an EORTC Early Clinical Trials Group (ECTG) study.
European journal of cancer (Oxford, England : 1990) 1994;30A(3):394-5.
1994: Treskes M; Boven E; van de Loosdrecht A A; Wijffels J F; Cloos J; Peters G J; Pinedo H M; van der Vijgh W J
Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice.
European journal of cancer (Oxford, England : 1990) 1994;30A(2):183-7.
1994: Lopez R; Peters G J; Smitskamp-Wilms E; Virizuela J A; van Ark-Otte J; Pinedo H M; Giaccone G
In vitro sequence-dependent synergistic effect of suramin and camptothecin.
European journal of cancer (Oxford, England : 1990) 1994;30A(11):1670-4.
1994: Lopez Lopez R; van Rijswijk R E; Wagstaff J; Pinedo H M; Peters G J
The synergistic and antagonistic effects of cytotoxic and biological agents on the in vitro antitumour effects of suramin.
European journal of cancer (Oxford, England : 1990) 1994;30A(10):1545-9.
1994: Haisma H J; van Muijen M; Pinedo H M; Boven E
Comparison of two anthracycline-based prodrugs for activation by a monoclonal antibody-beta-glucuronidase conjugate in the specific treatment of cancer.
Cell biophysics 1994;24-25():185-92.
1994: van Triest B; Telleman F; Pinedo H M; van der Wilt C L; Peters G J
Cross-resistance to thymidylate synthase inhibitors in P-glycoprotein and non-P-glycoprotein cell lines.
Advances in experimental medicine and biology 1994;370():189-93.
1993: van Gijn R; Kuijs S; Rosing H; Dubbelman A C; van Tellingen O; ten Bokkel Huinink W W; Pinedo H M; Beijnen J H
Determination of intoplicine, a new antitumour drug, in human faeces by normal-phase high-performance liquid chromatography with fluorescence detection.
Journal of pharmaceutical and biomedical analysis 1993;11(11-12):1345-8.
1993: Versantvoort C H; Schuurhuis G J; Pinedo H M; Eekman C A; Kuiper C M; Lankelma J; Broxterman H J
Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.
British journal of cancer 1993;68(5):939-46.
1993: Schuurhuis G J; van Heijningen T H; Cervantes A; Pinedo H M; de Lange J H; Keizer H G; Broxterman H J; Baak J P; Lankelma J
Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.
British journal of cancer 1993;68(5):898-908.
1993: Huizing M T; Keung A C; Rosing H; van der Kuij V; ten Bokkel Huinink W W; Mandjes I M; Dubbelman A C; Pinedo H M; Beijnen J H
Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(11):2127-35.
1993: Dercksen M W; Hoekman K; ten Bokkel Huinink W W; Rankin E M; Dubbelman R; van Tinteren H; Wagstaff J; Pinedo H M
Effects of interleukin-3 on myelosuppression induced by chemotherapy for ovarian cancer and small cell undifferentiated tumours.
British journal of cancer 1993;68(5):996-1003.
1993: van Groeningen C J; Meyer S; Vermorken J B; Nieweg M B; Cuesta M; Pinedo H M
[The treatment of liver metastases of colorectal tumors using intra-arterial fluorouracil via hepatic artery, administered with a completely implantable access system and a portable infusion pump]
Nederlands tijdschrift voor geneeskunde 1993;137(40):2039-43.
1993: Los G; van Vugt M J; den Engelse L; Pinedo H M
Effects of temperature on the interaction of cisplatin and carboplatin with cellular DNA.
Biochemical pharmacology 1993;46(7):1229-37.
1993: Pieters R C; Vermorken J B; Gall H E; Nauta J J; van Loenen A C; van Groeningen C J; van Rijswijk R E; Brenninkmeijer J H; Pinedo H M
A double-blind randomized crossover study to compare the antiemetic efficacy of 250 mg with 500 mg methylprednisolone succinate (Solu-Medrol) as a single intravenous dose in patients treated with noncisplatin chemotherapy.
Oncology 1993;50(4):316-22.
1993: Beijnen J H; Rosing H; ten Bokkel Huinink W W; Pinedo H M
High-performance liquid chromatographic analysis of the antitumour drug camptothecin and its lactone ring-opened form in rat plasma.
Journal of chromatography 1993;617(1):111-7.
1993: Peters G J; Laurensse E; Steinbusch H W; De Vente J; Smid K; Van der Wilt C L; Pinedo H M
Development, characterization and application of an antibody against 5-fluoro-2'deoxyuridine-5'monophosphate, the active metabolite of 5-fluorouracil.
Anticancer research 1993;13(4):835-9.
1993: Boven E; Schipper H; Erkelens C A; Hatty S A; Pinedo H M
The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer.
British journal of cancer 1993;68(1):52-6.
1993: Peters G J; Wets M; Keepers Y P; Oskam R; van Ark-Otte J; Noordhuis P; Smid K; Pinedo H M
Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism.
International journal of cancer. Journal international du cancer 1993;54(3):450-5.
1993: Pinedo H M
Dose effect relationship in breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(5):351-7.
1993: van Gijn R; Rosing H; ten Bokkel Huinink W W; van Tellingen O; Vermorken J B; Liefting A J; Bruno R; Pinedo H M; Beijnen J H
Determination of intoplicine, a new antitumour drug, in human whole blood and plasma by normal-phase high-performance liquid chromatography with fluorescence detection.
Journal of chromatography 1993;614(2):299-306.
1993: van Groeningen C J; Peters G J; Pinedo H M
Reversal of 5-fluorouracil-induced toxicity by oral administration of uridine.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(4):317-20.
1993: Boven E; Venema-Gaberscek E; Erkelens C A; Bissery M C; Pinedo H M
Antitumor activity of taxotere (RP 56976, NSC 628503), a new taxol analog, in experimental ovarian cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(4):321-4.
1993: van der Wilt C L; Pinedo H M; de Jong M; Peters G J
Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase.
Biochemical pharmacology 1993;45(5):1177-9.
1993: Baars J W; Wagstaff J; Van Groeningen C J; Vermorken J B; Bijvank E M; Pinedo H M; Nauta J J
Phase II study of interferon-gamma and interleukin-2: tachyphylaxis of toxicity to the liver during increasing immune enhancement.
Journal of the National Cancer Institute 1993;85(5):410-1.
1993: van Kalken C K; Broxterman H J; Pinedo H M; Feller N; Dekker H; Lankelma J; Giaccone G
Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
British journal of cancer 1993;67(2):284-9.
1993: Peters G J; Lankelma J; Kok R M; Noordhuis P; van Groeningen C J; van der Wilt C L; Meyer S; Pinedo H M
Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma.
Cancer chemotherapy and pharmacology 1993;31(4):269-76.
1993: Westerhof G R; Schornagel J H; Rijnboutt S; Pinedo H M; Jansen G
Identification of a reduced folate/methotrexate carrier in human KB-cells expressing high levels of membrane associated folate binding protein.
Advances in experimental medicine and biology 1993;338():771-4.
1993: Peters G J; van der Wilt C L; Cloos J; Pinedo H M
Development of a simple folylpolyglutamate synthetase assay in tissues and cell lines.
Advances in experimental medicine and biology 1993;338():651-4.
1993: Peters G J; Hoekman K; van Groeningen C J; van der Wilt C L; Smid K; Meijer S; Pinedo H M
Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent.
Advances in experimental medicine and biology 1993;338():613-6.
1993: van der Wilt C L; de Jong M; Braakhuis B J; Pinedo H M; Peters G J
The interval between methotrexate and leucovorin determines the efficacy of 5-fluorouracil modulation in vitro and in vivo.
Advances in experimental medicine and biology 1993;338():609-12.
1993: Los G; Tuyt L; van Vugt M; Schornagel J; Pinedo H M
Combination treatment of cis- and carboplatin in cancers restricted to the peritoneal cavity in the rat.
Cancer chemotherapy and pharmacology 1993;32(6):425-33.
1993: Pizao P E; Peters G J; Van Ark-Otte J; Smets L A; Smitskamp-Wilms E; Winograd B; Pinedo H M; Giaccone G
Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures.
European journal of cancer (Oxford, England : 1990) 1993;29A(11):1566-73.
1993: Peters G J; Codacci-Pisanelli G; van der Wilt C L; van Laar J A; Smid K; Noordhuis P; Pinedo H M
Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase.
Advances in experimental medicine and biology 1993;339():9-20; discussion 21.
1993: Verweij J; Pinedo H M
Changing concepts in the systemic treatment of locally advanced or metastatic soft tissue sarcomas.
Cancer treatment and research 1993;67():107-16.
1993: Van der Wilt C L; Smid K; Aherne G W; Pinedo H M; Peters G J
Evaluation of immunohistochemical staining and activity of thymidylate synthase in cell lines.
Advances in experimental medicine and biology 1993;338():605-8.
1992: Boven E; Hendriks H R; Erkelens C A; Pinedo H M
The anti-tumour effects of the prodrugs N-l-leucyl-doxorubicin and vinblastine-isoleucinate in human ovarian cancer xenografts.
British journal of cancer 1992;66(6):1044-7.
1992: Meijs W E; Herscheid J D; Haisma H J; Pinedo H M
Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1992;43(12):1443-7.
1992: Rodenhuis S; Baars J W; Schornagel J H; Vlasveld L T; Mandjes I; Pinedo H M; Richel D J
Feasibility and toxicity study of a high-dose chemotherapy regimen for autotransplantation incorporating carboplatin, cyclophosphamide and thiotepa.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3(10):855-60.
1992: ten Bokkel Huinink W W; Clavel M; Rodenhuis S; Guastalla J P; Franklin H R; Koier J J; Vlasveld T; Dalesio O; van Tinteren H; Pinedo H M
Mitoxantrone and GM-CSF: a phase I study with an escalated dose of mitoxantrone in breast cancer.
Pathologie-biologie 1992;39(9):962.
1992: Hendriks H R; Plowman J; Berger D P; Paull K D; Fiebig H H; Fodstad O; Dreef-van der Meulen H C; Henrar R E; Pinedo H M; Schwartsmann G
Preclinical antitumour activity and animal toxicology studies of rhizoxin, a novel tubulin-interacting agent.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3(9):755-63.
1992: Molthoff C F; Buist M R; Kenemans P; Pinedo H M; Boven E
Experimental and clinical analysis of the characteristics of a chimeric monoclonal antibody, MOv18, reactive with an ovarian cancer-associated antigen.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(11):2000-5.
1992: van Rijswijk R E; van Loenen A C; Wagstaff J; Meijer E; Lopez R; van Groeningen C J; Heimans J J; Pinedo H M
Suramin: rapid loading and weekly maintenance regimens for cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(11):1788-94.
1992: van Kalken C K; Giaccone G; van der Valk P; Kuiper C M; Hadisaputro M M; Bosma S A; Scheper R J; Meijer C J; Pinedo H M
Multidrug resistance gene (P-glycoprotein) expression in the human fetus.
The American journal of pathology 1992;141(5):1063-72.
1992: Baars J W; de Boer J P; Wagstaff J; Roem D; Eerenberg-Belmer A J; Nauta J; Pinedo H M; Hack C E
Interleukin-2 induces activation of coagulation and fibrinolysis: resemblance to the changes seen during experimental endotoxaemia.
British journal of haematology 1992;82(2):295-301.
1992: Baars J W; Coenen J L; Wagstaff J; van der Valk P; Pinedo H M
Lobular panniculitis after subcutaneous administration of interleukin-2 (IL-2), and its exacerbation during intravenous therapy with IL-2.
British journal of cancer 1992;66(4):698-9.
1992: Pizao P E; Lyaruu D M; Peters G J; van Ark-Otte J; Winograd B; Giaccone G; Pinedo H M
Growth, morphology and chemosensitivity studies on postconfluent cells cultured in 'V'-bottomed microtiter plates.
British journal of cancer 1992;66(4):660-5.
1992: van der Hem K G; Boven E; van Hennik M B; Pinedo H M
Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane.
The Journal of urology 1992;148(4):1256-9.
1992: Haisma H J; Boven E; van Muijen M; de Jong J; van der Vijgh W J; Pinedo H M
A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.
British journal of cancer 1992;66(3):474-8.
1992: Van der Wilt C L; Pinedo H M; Smid K; Peters G J
Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.
Cancer research 1992;52(18):4922-8.
1992: Haisma H J; Pinedo H M; Silva C A; Boven E
Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies directed against intracellular antigens.
Journal of immunological methods 1992;154(1):55-60.
1992: Lopez Lopez R; Peters G J; van Loenen A C; Pizao P E; van Rijswijk R E; Wagstaff J; Pinedo H M
The effect of schedule, protein binding and growth factors on the activity of suramin.
International journal of cancer. Journal international du cancer 1992;51(6):921-6.
1992: Pizao P E; Winograd B; Peters G J; Leyva A; Giaccone G; Pinedo H M
In vitro chemosensitivity testing of multilayered microcultures.
Anticancer research 1992;12(4):1319-22.
1992: Pinedo H M; van Rijswijk R E
Suramin awakes?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(6):875-7.
1992: Molthoff C F; Pinedo H M; Schlüper H M; Nijman H W; Boven E
Comparison of the pharmacokinetics, biodistribution and dosimetry of monoclonal antibodies OC125, OV-TL 3, and 139H2 as IgG and F(ab')2 fragments in experimental ovarian cancer.
British journal of cancer 1992;65(5):677-83.
1992: Molthoff C F; Pinedo H M; Schlüper H M; Rutgers D H; Boven E
Comparison of 131I-labelled anti-episialin 139H2 with cisplatin, cyclophosphamide or external-beam radiation for anti-tumor efficacy in human ovarian cancer xenografts.
International journal of cancer. Journal international du cancer 1992;51(1):108-15.
1992: Peters G J; van Groeningen C J; van der Wilt C L; Meijer S; Smid K; Laurensse E; Pinedo H M
Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin.
Seminars in oncology 1992;19(2 Suppl 3):26-35.
1992: van Groeningen C J; Peters G J; Pinedo H M
Modulation of fluorouracil toxicity with uridine.
Seminars in oncology 1992;19(2 Suppl 3):148-54.
1992: van der Wilt C L; Pinedo H M; Smid K; Cloos J; Noordhuis P; Peters G J
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Seminars in oncology 1992;19(2 Suppl 3):16-25.
1992: Treskes M; Boven E; Holwerda U; Pinedo H M; van der Vijgh W J
Time dependence of the selective modulation of cisplatin-induced nephrotoxicity by WR2721 in the mouse.
Cancer research 1992;52(8):2257-60.
1992: Los G; Smals O A; van Vugt M J; van der Vlist M; den Engelse L; McVie J G; Pinedo H M
A rationale for carboplatin treatment and abdominal hyperthermia in cancers restricted to the peritoneal cavity.
Cancer research 1992;52(5):1252-8.
1992: Baars J W; Wagstaff J; Hack C E; Wolbink G J; Eerenberg-Belmer A J; Pinedo H M
Angioneurotic oedema and urticaria during therapy with interleukin-2 (IL-2).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3(3):243-4.
1992: Scheper R J; Broxterman H J; Scheffer G L; Meijer C J; Pinedo H M
Drug-transporter proteins in clinical multidrug resistance.
Clinica chimica acta; international journal of clinical chemistry 1992;206(1-2):25-32.
1992: Peters G J; Kraal I; Pinedo H M
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
British journal of cancer 1992;65(2):229-33.
1992: Molthoff C F; Pinedo H M; Schlüper H M; Boven E
Influence of dose and schedule on the therapeutic efficacy of 131I-labelled monoclonal antibody 139H2 in a human ovarian cancer xenograft model.
International journal of cancer. Journal international du cancer 1992;50(3):474-80.
1992: Baars J W; Hack C E; Wagstaff J; Eerenberg-Belmer A J; Wolbink G J; Thijs L G; Strack van Schijndel R J; van der Vall H L; Pinedo H M
The activation of polymorphonuclear neutrophils and the complement system during immunotherapy with recombinant interleukin-2.
British journal of cancer 1992;65(1):96-101.
1992: Versantvoort C H; Broxterman H J; Pinedo H M; de Vries E G; Feller N; Kuiper C M; Lankelma J
Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression.
Cancer research 1992;52(1):17-23.
1992: Baars J W; Fonk J C; Scheper R J; von Blomberg-van der Flier B M; Bril H; von Valk P; Pinedo H M; Wagstaff J
Treatment with tumour infiltrating lymphocytes and interleukin-2 in patients with metastatic melanoma: a pilot study.
Biotherapy (Dordrecht, Netherlands) 1992;4(4):289-97.
1992: Tanis B C; Vermorken J B; ten Bokkel Huinink W W; van Oosterom A T; Splinter T A; Vendrik K J; Sleijfer D T; van der Burg M E; van der Putten E; Pinedo H M
Multicenter phase II study of spiroplatin.
Oncology 1992;49(2):99-103.
1992: Haisma H J; Boven E; van Muijen M; De Vries R; Pinedo H M
Analysis of a conjugate between anti-carcinoembryonic antigen monoclonal antibody and alkaline phosphatase for specific activation of the prodrug etoposide phosphate.
Cancer immunology, immunotherapy : CII 1992;34(5):343-8.
1992: de Lange J H; Schipper N W; Schuurhuis G J; ten Kate T K; van Heijningen T H; Pinedo H M; Lankelma J; Baak J P
Quantification by laser scan microscopy of intracellular doxorubicin distribution.
Cytometry 1992;13(6):571-6.
1992: Mans D R; Schuurhuis G J; Treskes M; Lafleur M V; Retèl J; Pinedo H M; Lankelma J
Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines.
European journal of cancer (Oxford, England : 1990) 1992;28A(8-9):1447-52.
1992: Treskes M; Holwerda U; Nijtmans L G; Pinedo H M; van der Vijgh W J
The reversal of cisplatin-protein interactions by the modulating agent WR2721 and its metabolites WR1065 and WR33278.
Cancer chemotherapy and pharmacology 1992;29(6):467-70.
1992: Peters G J; van der Wilt C L; Gyergyay F; van Laar J A; Treskes M; van der Vijgh W J; Pinedo H M
Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil.
International journal of radiation oncology, biology, physics 1992;22(4):785-9.
1991: van der Hem K G; van Groeningen C J; Pinedo H M
Late relapse of testicular cancer. A case report and a review of the literature.
The Netherlands journal of medicine 1991;39(5-6):353-5.
1991: Haisma H J; Pinedo H M; Kessel M A; van Muijen M; Roos J C; Plaizier M A; Martens H J; DeJager R; Boven E
Human IgM monoclonal antibody 16.88: pharmacokinetics and immunogenicity in colorectal cancer patients.
Journal of the National Cancer Institute 1991;83(24):1813-9.
1991: Hoekman K; Wagstaff J; van Groeningen C J; Vermorken J B; Boven E; Pinedo H M
Effects of recombinant human granulocyte-macrophage colony-stimulating factor on myelosuppression induced by multiple cycles of high-dose chemotherapy in patients with advanced breast cancer.
Journal of the National Cancer Institute 1991;83(21):1546-53.
1991: Schwartsmann G; Pinedo H M
Multicenter vs single center phase II evaluation of 4'-iodo-4'-deoxydoxorubicin in advanced breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1991;2(10):703-6.
1991: Peters G J; van Groeningen C J; Laurensse E J; Pinedo H M
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa.
Cancer 1991;68(9):1903-9.
1991: Schuurhuis G J; Broxterman H J; de Lange J H; Pinedo H M; van Heijningen T H; Kuiper C M; Scheffer G L; Scheper R J; van Kalken C K; Baak J P
Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein.
British journal of cancer 1991;64(5):857-61.
1991: Treskes M; Holwerda U; Klein I; Pinedo H M; van der Vijgh W J
The chemical reactivity of the modulating agent WR2721 (ethiofos) and its main metabolites with the antitumor agents cisplatin and carboplatin.
Biochemical pharmacology 1991;42(11):2125-30.
1991: Hoekman K; von Blomberg-van der Flier B M; Wagstaff J; Drexhage H A; Pinedo H M
Reversible thyroid dysfunction during treatment with GM-CSF.
Lancet 1991;338(8766):541-2.
1991: Maas I W; Boven E; Pinedo H M; Schlüper H M; Haisma H J
The effects of gamma-interferon combined with 5-fluorouracil or 5-fluoro-2'-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines.
International journal of cancer. Journal international du cancer 1991;48(5):749-56.
1991: Hack C E; Wagstaff J; Strack van Schijndel R J; Eerenberg A J; Pinedo H M; Thijs L G; Nuijens J H
Studies on the contact system of coagulation during therapy with high doses of recombinant IL-2: implications for septic shock.
Thrombosis and haemostasis 1991;65(5):497-503.
1991: Hoekman K; Wagstaff J; Boven E; van Groeningen C J; Vermorken J B; Pinedo H M
[The hematopoietic growth factor GM-CSF in chemotherapy for advanced breast carcinoma]
Nederlands tijdschrift voor geneeskunde 1991;135(10):415-9.
1991: Hoekman K; Wagstaff J; Ossenkoppele G J; Pinedo H M
[The application of hematopoietic growth factors in oncology]
Nederlands tijdschrift voor geneeskunde 1991;135(10):409-14.
1991: van Groeningen C J; Peters G J; Nadal J C; Laurensse E; Pinedo H M
Clinical and pharmacologic study of orally administered uridine.
Journal of the National Cancer Institute 1991;83(6):437-41.
1991: Molthoff C F; Calame J J; Pinedo H M; Boven E
Human ovarian cancer xenografts in nude mice: characterization and analysis of antigen expression.
International journal of cancer. Journal international du cancer 1991;47(1):72-9.
1991: Spoelstra E C; Pinedo H M; Dekker H; Peters G J; Lankelma J
Measurement of in vitro cellular pharmacokinetics of 5-fluorouracil in human and rat cancer cell lines and rat hepatocytes using a flow-through system.
Cancer chemotherapy and pharmacology 1991;27(4):320-5.
1991: Verweij J; Pinedo H M
Mitomycin C.
Cancer chemotherapy and biological response modifiers 1991;12():59-65.
1991: Leeuwenkamp O R; Neijt J P; van der Vijgh W J; Pinedo H M
Reaction kinetics of cisplatin and its monoaquated species with the modulating agents (di)mesna and thiosulphate.
European journal of cancer (Oxford, England : 1990) 1991;27(10):1243-7.
1991: Keepers Y P; Pizao P E; Peters G J; van Ark-Otte J; Winograd B; Pinedo H M
Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing.
European journal of cancer (Oxford, England : 1990) 1991;27(7):897-900.
1991: van Kalken C K; van der Hoeven J J; de Jong J; Giaccone G; Schuurhuis G J; Maessen P A; Blokhuis W M; van der Vijgh W J; Pinedo H M
Bepridil in combination with anthracyclines to reverse anthracycline resistance in cancer patients.
European journal of cancer (Oxford, England : 1990) 1991;27(6):739-44.
1991: Tanis B C; Vermorken J B; ten Bokkel Huinink W W; Klein I; Gall H; van Oosterom A T; Simonetti G; McVie J G; van der Vijgh W J; Pinedo H M
Phase I study of spiroplatin.
European journal of cancer (Oxford, England : 1990) 1991;27(3):268-73.
1991: Peters G J; van Groeningen C J; Laurensse E J; Pinedo H M
Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate.
European journal of cancer (Oxford, England : 1990) 1991;27(3):263-7.
1991: Peters G J; van Groeningen C J; van der Wilt C L; Smid K; Meijer S; Pinedo H M
Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in patients with colon cancer.
Advances in experimental medicine and biology 1991;309A():131-4.
1991: Van der Wilt C L; Marinelli A; Cloos J; Smid K; Pinedo H M; Peters G J
Isolated liver perfusion versus hepatic artery infusion with 5-fluorouracil in a rat model; effects on thymidylate synthase.
Advances in experimental medicine and biology 1991;309A():105-8.
1991: Molthoff C F; Pinedo H M; Schlüper H M; Boven E
Pharmacokinetics and biodistribution of a new anti-episialin monoclonal antibody 139H2 in ovarian-cancer-bearing nude mice.
Cancer immunology, immunotherapy : CII 1991;34(3):191-7.
1991: de Vries E G; Pinedo H M
Clinical implications of multidrug resistance to chemotherapy.
Cancer treatment and research 1991;57():171-86.
1991: van Kalken C K; Pinedo H M; Giaccone G
Multidrug resistance from the clinical point of view.
European journal of cancer (Oxford, England : 1990) 1991;27(11):1481-6.
1991: Verweij J; Pinedo H M
Systemic treatment of advanced or metastatic soft tissue sarcomas.
Cancer treatment and research 1991;56():75-91.
1990: Schuurhuis G J; Broxterman H J; Pinedo H M; van Heijningen T H; van Kalken C K; Vermorken J B; Spoelstra E C; Lankelma J
The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance.
British journal of cancer 1990;62(4):591-4.
1990: Verweij J; Pinedo H M
Mitomycin C: mechanism of action, usefulness and limitations.
Anti-cancer drugs 1990;1(1):5-13.
1990: Schuurhuis G J; Pinedo H M; Broxterman H J; van Kalken C K; Kuiper C M; Lankelma J
Differential sensitivity of multi-drug-resistant and -sensitive cells to resistance-modifying agents and the relation with reversal of anthracycline resistance.
International journal of cancer. Journal international du cancer 1990;46(2):330-6.
1990: de Jong J; Maessen P A; Akkerdaas A; Cheung S F; Pinedo H M; van der Vijgh W J
Sensitive method for the determination of daunorubicin and all its known metabolites in plasma and heart by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography 1990;529(2):359-68.
1990: Peters G J; Schwartsmann G; Nadal J C; Laurensse E J; van Groeningen C J; van der Vijgh W J; Pinedo H M
In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.
Cancer research 1990;50(15):4644-9.
1990: Broxterman H J; Pinedo H M; Schuurhuis G J; Lankelma J
Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
British journal of cancer 1990;62(1):85-8.
1990: Mans D R; Retèl J; van Maanen J M; Lafleur M V; van Schaik M A; Pinedo H M; Lankelma J
Role of the semi-quinone free radical of the anti-tumour agent etoposide (VP-16-213) in the inactivation of single- and double-stranded phi X174 DNA.
British journal of cancer 1990;62(1):54-60.
1990: de Jong J; Schoofs P R; Onderwater R C; van der Vijgh W J; Pinedo H M; Bast A
Isolated mouse atrium as a model to study anthracycline cardiotoxicity: the role of the beta-adrenoceptor system and reactive oxygen species.
Research communications in chemical pathology and pharmacology 1990;68(3):275-89.
1990: Boven E; Erkelens C A; Luning M; Pinedo H M
Activity of GR30921X (NSC 382057) and GR63178A (NSC D611615) in human ovarian cancer lines.
British journal of cancer 1990;61(5):709-11.
1990: Peters G J; Pinedo H M; Ferwerda W; de Graaf T W; van Dijk W
Do antimetabolites interfere with the glycosylation of cellular glycoconjugates?
European journal of cancer (Oxford, England : 1990) 1990;26(4):516-23.
1990: Peters G J; Nadal J C; Laurensse E J; de Kant E; Pinedo H M
Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer.
Biochemical pharmacology 1990;39(1):135-44.
1990: van der Vijgh W J; Maessen P A; Pinedo H M
Comparative metabolism and pharmacokinetics of doxorubicin and 4'-epidoxorubicin in plasma, heart and tumor of tumor-bearing mice.
Cancer chemotherapy and pharmacology 1990;26(1):9-12.
1990: Keizer H G; Pinedo H M; Schuurhuis G J; Joenje H
Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity.
Pharmacology & therapeutics 1990;47(2):219-31.
1990: Leeuwenkamp O R; van der Vijgh W J; Neijt J P; Pinedo H M
Reaction kinetics of cisplatin and its monoaquated species with the (potential) renal protecting agents (di)mesna and thiosulfate. Estimation of the effect of protecting agents on the plasma and peritoneal AUCs of CDDP.
Cancer chemotherapy and pharmacology 1990;27(2):111-4.
1990: Boven E; Schlüper H M; Erkelens C A; Pinedo H M
Doxorubicin compared with related compounds in a nude mouse model for human ovarian cancer.
European journal of cancer (Oxford, England : 1990) 1990;26(9):983-6.
1990: Verweij J; Pinedo H M
Mitomycin C.
Cancer chemotherapy and biological response modifiers 1990;11():67-73.
1990: van der Valk P; van Kalken C K; Ketelaars H; Broxterman H J; Scheffer G; Kuiper C M; Tsuruo T; Lankelma J; Meijer C J; Pinedo H M
Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1990;1(1):56-64.
1989: van Groeningen C J; Gall H E; Simons K A; van Loenen A C; Knobf M K; Nauta J; Vermorken J B; Pinedo H M
Comparison of two different high doses of metoclopramide in the prevention of chemotherapy-induced emesis.
The Netherlands journal of medicine 1989;35(5-6):283-94.
1989: Schuurhuis G J; Broxterman H J; Cervantes A; van Heijningen T H; de Lange J H; Baak J P; Pinedo H M; Lankelma J
Quantitative determination of factors contributing to doxorubicin resistance in multidrug-resistant cells.
Journal of the National Cancer Institute 1989;81(24):1887-92.
1989: Stoter G; Koopman A; Vendrik C P; Struyvenberg A; Sleyfer D T; Willemse P H; Schraffordt Koops H; van Oosterom A T; ten Bokkel Huinink W W; Pinedo H M
Ten-year survival and late sequelae in testicular cancer patients treated with cisplatin, vinblastine, and bleomycin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(8):1099-104.
1989: Nadal J C; van Groeningen C J; Pinedo H M; Peters G J
Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma.
Investigational new drugs 1989;7(2-3):163-72.
1989: Gundersen S; Dombernowsky P; Cavalli F; Bruntsch U; Renard J; Van Glabbeke M; Pinedo H
TCNU (LS 2667), a new active drug in the treatment of advanced colorectal cancer. EORTC Early Clinical Trials Group.
European journal of cancer & clinical oncology 1989;25(7):1095-7.
1989: Boven E; Schlüper H M; Erkelens C A; Luning M; Pinedo H M
A nude mouse-phase II model for human ovarian cancer.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1989;165(7):534-5.
1989: de Kant E; Pinedo H M; Laurensse E; Peters G J
The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by brequinar sodium.
Cancer letters 1989;46(2):123-7.
1989: Boven E; Calame J J; Molthoff C F; Pinedo H M
Characterization and chemotherapy of human soft tissue sarcoma (STS) lines grown in nude mice.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1989;165(7):538-9.
1989: Molthoff C F; Boven E; Calame J J; van Beek P J; Pinedo H M
Characterization of human ovarian cancer lines with a panel of monoclonal antibodies (MoAbs).
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1989;165(7):494-5.
1989: Keizer H G; De Leeuw S J; Van Rijn J; Pinedo H M; Joenje H
Effect of artificial electron acceptors on the cytotoxicity of mitomycin C and doxorubicin in human lung tumor cells.
European journal of cancer & clinical oncology 1989;25(7):1113-8.
1989: de Graeff A; Vendrik C P; Pinedo H M
Myelodysplastic syndrome and acute leukaemia following treatment of soft tissue sarcoma.
The Netherlands journal of medicine 1989;34(5-6):251-7.
1989: Keizer H G; Schuurhuis G J; Broxterman H J; Lankelma J; Schoonen W G; van Rijn J; Pinedo H M; Joenje H
Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells.
Cancer research 1989;49(11):2988-93.
1989: Wagstaff J; Vermorken J B; Schwartsmann G; Scheper R J; Hack C E; Nuijens J H; Eerenberg-Belmer A J; Pinedo H M
A progress report of a phase I study of interferon-gamma and interleukin-2 and some comments on the mechanism of the toxicity due to interleukin-2.
Cancer treatment reviews 1989;16 Suppl A():105-9.
1989: Smyth J F; Gundersen S; Renard J; Pinedo H M
Randomized phase II trial of TCNU versus mitozolomide in malignant melanoma. EORTC Early Clinical Trials Group.
European journal of cancer & clinical oncology 1989;25(4):755-7.
1989: Broxterman H J; Pinedo H M; Kuiper C M; Schuurhuis G J; Lankelma J
Glycolysis in P-glycoprotein-overexpressing human tumor cell lines. Effects of resistance-modifying agents.
FEBS letters 1989;247(2):405-10.
1989: Peters G J; Braakhuis B J; de Bruijn E A; Laurensse E J; van Walsum M; Pinedo H M
Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
British journal of cancer 1989;59(3):327-34.
1989: Broxterman H J; Pinedo H M; Kuiper C M; van der Hoeven J J; de Lange P; Quak J J; Scheper R J; Keizer H G; Schuurhuis G J; Lankelma J
Immunohistochemical detection of P-glycoprotein in human tumor cells with a low degree of drug resistance.
International journal of cancer. Journal international du cancer 1989;43(2):340-3.
1989: Dalton W S; Grogan T M; Rybski J A; Scheper R J; Richter L; Kailey J; Broxterman H J; Pinedo H M; Salmon S E
Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation.
Blood 1989;73(3):747-52.
1989: Pladdet I; Boven E; Nauta J; Pinedo H M
Palliative care for brain metastases of solid tumour types.
The Netherlands journal of medicine 1989;34(1-2):10-21.
1989: van Groeningen C J; Peters G J; Leyva A; Laurensse E; Pinedo H M
Reversal of 5-fluorouracil-induced myelosuppression by prolonged administration of high-dose uridine.
Journal of the National Cancer Institute 1989;81(2):157-62.
1989: van Groeningen C J; Peters G J; Pinedo H M
Lack of effectiveness of combined 5-fluorouracil and leucovorin in patients with 5-fluorouracil-resistant advanced colorectal cancer.
European journal of cancer & clinical oncology 1989;25(1):45-9.
1989: Schwartsmann G; Bork E; Vermorken J B; Nieboer C; Dodion P; ten Bokkel Huinink W W; Seldenrijk C A; Armand J P; Pinedo H M
Mucocutaneous side effects of Brequinar sodium. A new inhibitor of pyrimidine de novo biosynthesis.
Cancer 1989;63(2):243-8.
1989: van Hennik M B; van der Vijgh W J; Klein I; Vermorken J B; Pinedo H M
Human pharmacokinetics of carboplatin after oral administration.
Cancer chemotherapy and pharmacology 1989;23(2):126-7.
1989: Peters G J; Laurensse E J; van Groeningen C J; Meijer S; Pinedo H M
In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil.
Advances in experimental medicine and biology 1989;253A():439-45.
1989: Verweij J; van Groeningen C J; Pinedo H M
Chemotherapy in advanced soft tissue sarcomas.
Cancer treatment and research 1989;44():75-92.
1989: Peters G J; Laurensse E; de Kant E; Nadal J C; Pinedo H M
The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of brequinar sodium (DUP-785; NSC 368390).
Advances in experimental medicine and biology 1989;253B():375-82.
1989: Laurensse E J; Braakhuis B J; Pinedo H M; Peters G J
Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors.
Advances in experimental medicine and biology 1989;253B():327-34.
1988: Schwartsmann G; van der Vijgh W J; Klein I; van Groeningen C J; Vermorken J B; Pinedo H M
Pharmacokinetics of Brequinar sodium (NSC 368390; DUP 785) in cerebrospinal fluid.
European journal of cancer & clinical oncology 1988;24(12):1903-4.
1988: Brinkman-Woltjer L F; Vermorken J B; van Groeningen C J; Gall H E; Pinedo H M
[Phase I studies as non-therapeutic trials in oncology]
Nederlands tijdschrift voor geneeskunde 1988;132(51):2321-5.
1988: van Groeningen C J; Pinedo H M; Heddes J; Kok R M; de Jong A P; Wattel E; Peters G J; Lankelma J
Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule.
Cancer research 1988;48(23):6956-61.
1988: Boven E; Tierie A H; Stam J; Pinedo H M
Combined radiation therapy and daily low-dose cisplatin for inoperable, locally advanced non-small cell lung cancer: results of a phase II trial.
Seminars in oncology 1988;15(6 Suppl 7):18-9.
1988: van Maanen J M; Retèl J; de Vries J; Pinedo H M
Mechanism of action of antitumor drug etoposide: a review.
Journal of the National Cancer Institute 1988;80(19):1526-33.
1988: Laurensse E J; Pinedo H M; Peters G J
A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography.
Clinica chimica acta; international journal of clinical chemistry 1988;178(1):71-8.
1988: van der Vijgh W J; van Velzen D; van der Poort J S; Schlüper H M; Mross K; Feijen J; Pinedo H M
Morphometric study of myocardial changes during doxorubicin-induced cardiomyopathy in mice.
European journal of cancer & clinical oncology 1988;24(10):1603-8.
1988: Pinedo H M; Peters G F
Fluorouracil: biochemistry and pharmacology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(10):1653-64.
1988: van Maanen J M; Lafleur M V; Mans D R; van den Akker E; de Ruiter C; Kootstra P R; Pappie D; de Vries J; Retèl J; Pinedo H M
Effects of the ortho-quinone and catechol of the antitumor drug VP-16-213 on the biological activity of single-stranded and double-stranded phi X174 DNA.
Biochemical pharmacology 1988;37(19):3579-89.
1988: Van Maanen J M; van den Akker E; de Vries J; Bakkenist T R; Lankelma J; Retèl J; Pinedo H M
Structure-bioactivation relationship of a series of podophyllotoxin derivatives.
European journal of cancer & clinical oncology 1988;24(9):1415-9.
1988: Holdener E E; ten Bokkel Huinink W W; Decoster G; Ludwig C; Renard G; Pinedo H M
Phase II trial of menogaril in advanced colorectal cancer.
Investigational new drugs 1988;6(3):227-30.
1988: Schwartsmann G; Peters G J; Laurensse E; de Waal F C; Loonen A H; Leyva A; Pinedo H M
DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects.
Biochemical pharmacology 1988;37(17):3257-66.
1988: Keizer H G; van Rijn J; Pinedo H M; Joenje H
Effect of endogenous glutathione, superoxide dismutases, catalase, and glutathione peroxidase on adriamycin tolerance of Chinese hamster ovary cells.
Cancer research 1988;48(16):4493-7.
1988: Dombernowsky P; Clavel M; Smyth J F; Howell A; van Glabekke M; Renard J; Pinedo H M
Phase II study of TCNU in advanced breast cancer.
European journal of cancer & clinical oncology 1988;24(8):1377-8.
1988: Clavel M; Monfardini S; Gundersen S; Kaye S; Siegenthaler P; Renard J; van Glabbeke M; Pinedo H M
Phase II study of iproplatin (CHIP, JM-9) in advanced testicular cancers progressing after prior chemotherapy.
European journal of cancer & clinical oncology 1988;24(8):1345-8.
1988: Goey S H; Wagstaff J; Pinedo H M
Biological approaches to the treatment of cancer.
The Netherlands journal of medicine 1988;33(1-2):41-7.
1988: Schwartsmann G; Winograd B; Pinedo H M
The main steps in the development of anticancer agents.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1988;12(4):301-13.
1988: Cervantes A; Pinedo H M; Lankelma J; Schuurhuis G J
The role of oxygen-derived free radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells.
Cancer letters 1988;41(2):169-77.
1988: Broxterman H J; Kuiper C M; Schuurhuis G J; Tsuruo T; Pinedo H M; Lankelma J
Increase of daunorubicin and vincristine accumulation in multidrug resistant human ovarian carcinoma cells by a monoclonal antibody reacting with P-glycoprotein.
Biochemical pharmacology 1988;37(12):2389-93.
1988: van der Vijgh W J; Elferink F; Vermorken J B; ten Bokkel Huinink W W; Klein I; Gall H E; Simonetti G; McVie J G; Pinedo H M
Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of aqua (1,1-bis(aminomethyl)cyclohexane) sulfatoplatinum (II) (spiroplatin) during a phase I trial.
European journal of cancer & clinical oncology 1988;24(4):621-7.
1988: Broxterman H J; Pinedo H M; Kuiper C M; Kaptein L C; Schuurhuis G J; Lankelma J
Induction by verapamil of a rapid increase in ATP consumption in multidrug-resistant tumor cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(7):2278-82.
1988: Boven E; Winograd B; Fodstad O; Lobbezoo M W; Pinedo H M
Preclinical phase II studies in human tumor lines: a European multicenter study.
European journal of cancer & clinical oncology 1988;24(3):567-73.
1988: Peters G J; van Dijk J; Laurensse E; van Groeningen C J; Lankelma J; Leyva A; Nadal J C; Pinedo H M
In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.
British journal of cancer 1988;57(3):259-65.
1988: Goey S H; Voerman H J; Strack van Schijndel R J; van der Hoeven J J; Wagstaff J; Thijs L G; Pinedo H M
Swelling of metastatic tumors with high-dose interleukin therapy.
The New England journal of medicine 1988;318(10):643-4.
1988: Mross K; Maessen P; van der Vijgh W J; Gall H; Boven E; Pinedo H M
Pharmacokinetics and metabolism of epidoxorubicin and doxorubicin in humans.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(3):517-26.
1988: Lankelma J; Koopman G; van Grondelle R; Pinedo H M
In-beam light absorption measurement of anthracyclines in cells with a flow-through system.
Biochimica et biophysica acta 1988;964(2):200-6.
1988: van Glabbeke M; Renard J; Pinedo H M; Cavalli F; Vermorken J; Sessa C; Abele R; Clavel M; Monfardini S
Iproplatin and carboplatin induced toxicities: overview of phase II clinical trial conducted by the EORTC Early Clinical Trials Cooperative Group (ECTG).
European journal of cancer & clinical oncology 1988;24(2):255-62.
1988: Lankelma J; Stuurman M; van Hoogenhuijze J; van Bochove A; Vermorken J B; Verweij J; Pinedo H M
The pharmacokinetic plasma profile of mitomycin C, measured after sequential intermittent intravenous administration.
European journal of cancer & clinical oncology 1988;24(2):175-80.
1988: Joss R A; Monfardini S; Hansen M; Dombernowsky P; Renard J; Pinedo H M
Negative phase II trial of menogaril in advanced squamous, adeno- and large cell carcinoma of the lung.
European journal of cancer & clinical oncology 1988;24(2):263-5.
1988: Sessa C; Vermorken J; Renard J; Kaye S; Smith D; ten Bokkel Huinink W; Cavalli F; Pinedo H
Phase II study of iproplatin in advanced ovarian carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(1):98-105.
1988: Maessen P A; Pinedo H M; Mross K B; van der Vijgh W J
New method for the determination of doxorubicin, 4'-epidoxorubicin and all known metabolites in cardiac tissue.
Journal of chromatography 1988;424(1):103-10.
1988: den Hartigh J; Verweij J; Pinedo H M
Mitomycin C.
Cancer chemotherapy and biological response modifiers 1988;10():45-9.
1988: Verweij J; Funke-Küpper A J; Teule G J; Pinedo H M
A prospective study on the dose dependency of cardiotoxicity induced by mitomycin C.
Medical oncology and tumor pharmacotherapy 1988;5(3):159-63.
1988: Kerpel-Fronius S; Verwey J; Stuurman M; Kanyár B; Lelieveld P; Pinedo H M
Pharmacokinetics and toxicity of mitomycin C in rodents, given alone, in combination, or after induction of microsomal drug metabolism.
Cancer chemotherapy and pharmacology 1988;22(2):104-8.
1988: Verweij J; Kerpel-Fronius S; Stuurman M; van Triet A J; van Hattum L; de Vries J; Pinedo H M
Mitomycin C-induced organ toxicity in Wistar rats: a study with special focus on the kidney.
Journal of cancer research and clinical oncology 1988;114(2):137-41.
1988: van der Hoeven J J; Pinedo H M
Endocrine tumors.
Cancer chemotherapy and biological response modifiers 1988;10():265-70.
1988: Nadal J C; Van Groeningen C J; Pinedo H M; Peters G J
In vivo potentiation of 5-fluorouracil by leucovorin in murine colon carcinoma.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1988;42(6):387-93.
1988: van Maanen J M; Verkerk U H; Broersen J; Lafleur M V; De Vries J; Retèl J; Pinedo H M
Semi-quinone formation from the catechol and ortho-quinone metabolites of the antitumor agent VP-16-213.
Free radical research communications 1988;4(6):371-84.
1987: Peters G J; Laurensse E; Leyva A; Pinedo H M
Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity.
European journal of cancer & clinical oncology 1987;23(12):1869-81.
1987: Elferink F; van der Vijgh W J; Klein I; Vermorken J B; Gall H E; Pinedo H M
Pharmacokinetics of carboplatin after i.v. administration.
Cancer treatment reports 1987;71(12):1231-7.
1987: van Hennik M B; van der Vijgh W J; Klein I; Elferink F; Vermorken J B; Winograd B; Pinedo H M
Comparative pharmacokinetics of cisplatin and three analogues in mice and humans.
Cancer research 1987;47(23):6297-301.
1987: Abele R; Clavel M; Dodion P; Bruntsch U; Gundersen S; Smyth J; Renard J; van Glabbeke M; Pinedo H M
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas.
European journal of cancer & clinical oncology 1987;23(12):1921-4.
1987: van der Vijgh W J; Van Velzen D; Van der Poort J S; Schlüper H M; Mross K; Feijen J; Pinedo H M
Morphometric study of myocardial changes during puromycin aminonucleoside induced nephropathy in rats.
Anticancer research 1987;7(6):1111-5.
1987: Gundersen S; Monfardini S; Renard G; Van Glabbeke M; Pinedo H
Phase II trial of menogaril in advanced malignant melanoma. An EORTC trial.
European journal of cancer & clinical oncology 1987;23(11):1707-8.
1987: van Harskamp G; Boven E; Vermorken J B; van Deutekom H; Stam J; Njo K H; Karim A B; Tierie A H; Golding R P; Pinedo H M
Phase II trial of combined radiotherapy and daily low-dose cisplatin for inoperable, locally advanced non-small cell lung cancer (NSCLC).
International journal of radiation oncology, biology, physics 1987;13(11):1735-8.
1987: Wiggenraad R; Boven E; Vermorken J B; Pinedo H M
[Extensive soft-tissue sarcoma: a hopeless situation?]
Nederlands tijdschrift voor geneeskunde 1987;131(41):1793-6.
1987: Mouridsen H T; Bastholt L; Somers R; Santoro A; Bramwell V; Mulder J H; van Oosterom A T; Buesa J; Pinedo H M; Thomas D
Adriamycin versus epirubicin in advanced soft tissue sarcomas. A randomized phase II/phase III study of the EORTC Soft Tissue and Bone Sarcoma Group.
European journal of cancer & clinical oncology 1987;23(10):1477-83.
1987: Beer M; Cavalli F; Kaye S B; Lev L M; Clavel M; Smyth J; van Glabbeke M; Renard J; Pinedo H M
A phase II study of carboplatin in advanced or metastatic stomach cancer.
European journal of cancer & clinical oncology 1987;23(10):1565-7.
1987: van Maanen J M; de Vries J; Pappie D; van den Akker E; Lafleur V M; Retèl J; van der Greef J; Pinedo H M
Cytochrome P-450-mediated O-demethylation: a route in the metabolic activation of etoposide (VP-16-213).
Cancer research 1987;47(17):4658-62.
1987: Schwartsmann G; Madan K; Heins Y; Pinedo H M; Leyva A
Double-minute chromatin bodies in HL-60 leukemia cells sensitive and resistant to differentiation inducing agents.
Cell biology international reports 1987;11(9):651-5.
1987: Verweij J; van Zanten T; Souren T; Golding R; Pinedo H M
Prospective study on the dose relationship of mitomycin C-induced interstitial pneumonitis.
Cancer 1987;60(4):756-61.
1987: Maessen P A; Mross K B; Pinedo H M; van der Vijgh W J
Improved method for the determination of 4'-epidoxorubicin and seven metabolites in plasma by high-performance liquid chromatography.
Journal of chromatography 1987;417(2):339-46.
1987: Snow G B; De Vries N; Van Zandwijk N; Pinedo H M
Second primary cancers in the lung in head and neck cancer patients: a challenge.
European journal of cancer & clinical oncology 1987;23(6):883-6.
1987: Schwartsmann G; Pinedo H M
Clinical trials in advanced breast cancer.
European journal of cancer & clinical oncology 1987;23(6):595-7.
1987: van Hoogenhuijze J; Lankelma J; Stam J; Pinedo H M
Unchanged pharmacokinetics of VP-16-213 (etoposide, NSC 141540) during concomitant administration of doxorubicin and cyclophosphamide.
European journal of cancer & clinical oncology 1987;23(6):807-11.
1987: Schwartsmann G; Pinedo H M; Leyva A
Resistance of HL-60 promyelocytic leukemia cells to induction of differentiation and its reversal by combination treatment.
European journal of cancer & clinical oncology 1987;23(6):739-43.
1987: Dombernowsky P; Buesa J; Pinedo H M; Santoro A; Mouridsen H; Somers R; Bramwell V; Onsrud M; Rouesse J; Thomas D
VP-16 in advanced soft tissue sarcoma: a phase II study of the EORTC soft tissue and bone sarcoma group.
European journal of cancer & clinical oncology 1987;23(5):579-80.
1987: Mross K; Maessen P; van der Vijgh W J; Bogdanowicz J F; Kurth K H; Pinedo H M
Absorption of epi-doxorubicin after intravesical administration in patients with in situ transitional cell carcinoma of the bladder.
European journal of cancer & clinical oncology 1987;23(5):505-8.
1987: Abele R; Clavel M; Monfardini S; Bruntsch U; Renard J; van Glabbeke M; Pinedo H M
Phase II study of iproplatin (CHIP, JM-9) in advanced squamous cell carcinoma of the head and neck.
European journal of cancer & clinical oncology 1987;23(4):387-9.
1987: Broxterman H J; Kuiper C M; Schuurhuis G J; van der Hoeven J J; Pinedo H M; Lankelma J
Daunomycin accumulation in resistant tumor cells as a screening model for resistance modifying drugs: role of protein binding.
Cancer letters 1987;35(1):87-95.
1987: Peters G J; van Groeningen C J; Laurensse E; Kraal I; Leyva A; Lankelma J; Pinedo H M
Effect of pyrimidine nucleosides on body temperatures of man and rabbit in relation to pharmacokinetic data.
Pharmaceutical research 1987;4(2):113-9.
1987: Broxterman H J; Sprenkels-Schotte C; Engelen P; Leyva A; Pinedo H M
Analysis of human ascites effect on clonogenic growth of human tumor cell lines and NRK-49F cells in soft agar.
International journal of cell cloning 1987;5(2):158-69.
1987: Peters G J; Van Dijk J; Nadal J C; Van Groeningen C J; Lankelma J; Pinedo H M
Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer.
In vivo (Athens, Greece) 1987;1(2):113-7.
1987: Peters G J; Laurensse E; Leyva A; Pinedo H M
A sensitive, nonradiometric assay for dihydroorotic acid dehydrogenase using anion-exchange high-performance liquid chromatography.
Analytical biochemistry 1987;161(1):32-8.
1987: Verwey J; de Vries J; Pinedo H M
Mitomycin C-induced renal toxicity, a dose-dependent side effect?
European journal of cancer & clinical oncology 1987;23(2):195-9.
1987: Verweij J; van der Burg M E; Pinedo H M
Mitomycin C-induced hemolytic uremic syndrome. Six case reports and review of the literature on renal, pulmonary and cardiac side effects of the drug.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1987;8(1):33-41.
1987: Winograd B; Boven E; Lobbezoo M W; Pinedo H M
Human tumor xenografts in the nude mouse and their value as test models in anticancer drug development (review).
In vivo (Athens, Greece) 1987;1(1):1-13.
1987: Peters G J; van Groeningen C J; Laurensse E J; Lankelma J; Leyva A; Pinedo H M
Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites.
Cancer chemotherapy and pharmacology 1987;20(2):101-8.
1987: Schuurhuis G J; Broxterman H J; van der Hoeven J J; Pinedo H M; Lankelma J
Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and -sensitive cell lines. A comparison with verapamil.
Cancer chemotherapy and pharmacology 1987;20(4):285-90.
1987: Maessen P A; Mross K B; Pinedo H M; van der Vijgh W J
Metabolism of epidoxorubicin in animals: absence of glucuronidation.
Cancer chemotherapy and pharmacology 1987;20(1):85-7.
1987: Den Hartigh J; Verweij J; Pinedo H M
Mitomycin C.
Cancer chemotherapy and biological response modifiers 1987;9():56-62.
1987: Verweij J; den Hartigh J; Stuurman M; de Vries J; Pinedo H M
Relationship between clinical parameters and pharmacokinetics of mitomycin C.
Journal of cancer research and clinical oncology 1987;113(1):91-4.
1987: Verweij J; Kerpel-Fronius S; Stuurman M; de Vries J; Pinedo H M
Absence of interaction between furosemide and mitomycin C.
Cancer chemotherapy and pharmacology 1987;19(1):84-6.
1987: Hegedüs L; van der Vijgh W J; Klein I; Kerpel-Fronius S; Pinedo H M
Chemical reactivity of cisplatin bound to human plasma proteins.
Cancer chemotherapy and pharmacology 1987;20(3):211-2.
1987: Peters G J; Sharma S L; Laurensse E; Pinedo H M
Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390).
Investigational new drugs 1987;5(3):235-44.
1986: Weenen H; Osterop A P; van der Poort S E; Lankelma J; van der Vijgh W J; Pinedo H M
Analysis of doxorubicin, 4'-epidoxorubicin, and their metabolites by liquid chromatography.
Journal of pharmaceutical sciences 1986;75(12):1201-4.
1986: Levva A; Schwartsmann G; Boeije L C; Pinedo H M; de Waal F
Growth inhibitory effects of 5-aza-2'-deoxycytidine in HL-60 promyelocytic leukemia cells resistant to differentiation induction.
Biochemical and biophysical research communications 1986;141(2):629-35.
1986: van Groeningen C J; Pinedo H M
[Cisplatin in the treatment of testicular carcinoma]
Nederlands tijdschrift voor geneeskunde 1986;130(44):1980-4.
1986: Elferink F; van der Vijgh W J; Pinedo H M
On-line differential pulse polarographic detection of carboplatin in biological samples after chromatographic separation.
Analytical chemistry 1986;58(11):2293-6.
1986: van Groeningen C J; Leyva A; O'Brien A M; Gall H E; Pinedo H M
Phase I and pharmacokinetic study of 5-aza-2'-deoxycytidine (NSC 127716) in cancer patients.
Cancer research 1986;46(9):4831-6.
1986: Nauta M M; Boven E; Schlüper H M; Erkelens C A; Pinedo H M
Enhanced transplantability of human ovarian cancer lines in cyclophosphamide-pretreated nude mice.
British journal of cancer 1986;54(2):331-5.
1986: Peters G J; Laurensse E J; Leyva A; Pinedo H M
Tissue homogenization using a micro-dismembrator for the measurement of enzyme activities.
Clinica chimica acta; international journal of clinical chemistry 1986;158(2):193-8.
1986: Bruntsch U; Dodion P; Ten Bokkel Huinink W W; Hansen H H; Pinedo H M; Hansen M; Renard J; Van Glabbeke M
Primary resistance of renal adenocarcinoma to 1,2,4-triglycidylurazol (TGU, NSC 332488), a new triexpoxide cytostatic agent--a phase II study of the EORTC early clinical trials group.
European journal of cancer & clinical oncology 1986;22(6):697-9.
1986: van Groeningen C J; Leyva A; Kraal I; Peters G J; Pinedo H M
Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.
Cancer treatment reports 1986;70(6):745-50.
1986: Winograd B; Vermorken J B; ten Bokkel Huinink W W; Simonetti G; Gall H E; Knobf M K; van der Vijgh W J; McVie J G; Pinedo H M
Phase I study of ethylenediamine platinum(II) malonate (NSC 146 068), a second generation platinum analogue.
Cancer research 1986;46(4 Pt 2):2148-51.
1986: Elferink F; van der Vijgh W J; Klein I; Pinedo H M
Interaction of cisplatin and carboplatin with sodium thiosulfate: reaction rates and protein binding.
Clinical chemistry 1986;32(4):641-5.
1986: Pinedo H M; Verweij J
The treatment of soft tissue sarcomas with focus on chemotherapy: a review.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1986;5(3):193-205.
1986: van Groeningen C J; Meyer S; Dijkhuizen H; Gall H; Pinedo H M
[Clinical experience with a fully implantable delivery system (Port-a-Cath) for the cytostatic treatment of patients with cancer]
Nederlands tijdschrift voor geneeskunde 1986;130(6):258-61.
1986: Vermorken J B; van der Vijgh W J; Klein I; Gall H E; van Groeningen C J; Hart G A; Pinedo H M
Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of cisplatin.
Clinical pharmacology and therapeutics 1986;39(2):136-44.
1986: Boven E; Pinedo H M
Monoclonal antibodies in cancer treatment: where do we stand after 10 years?
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1986;5(2):109-17.
1986: Peters G J; Laurensse E; Leyva A; Lankelma J; Pinedo H M
Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.
Cancer research 1986;46(1):20-8.
1986: Dombernowsky P; Mouridsen H; Schütte J; Santoro A; Rouessé J; Somers R; Stewart W; Pinedo H M; von Oosterom A; Blackledge G
Phase II study of ifosfamide + adriamycin in advanced soft tissue sarcoma in adults. A preliminary analysis.
Cancer chemotherapy and pharmacology 1986;18 Suppl 2():S17.
1986: Vermorken J B; van der Vijgh W J; Klein I; Gall H E; Splinter T A; Hart A A; Pinedo H M
Pharmacokinetic comparison of cisplatin in solution with common lyophilized cisplatinum (Platinol).
Therapeutic drug monitoring 1986;8(3):264-8.
1986: Pinedo H M
Development of new anti-cancer drugs.
Medical oncology and tumor pharmacotherapy 1986;3(2):63-9.
1986: Verwey J; Van Lingen A; Teule J J; Heidendal G A; Pinedo H M
The cold pressor test during radionuclide ventriculography: a feasibility study in cancer patients.
Medical oncology and tumor pharmacotherapy 1986;3(1):11-4.
1986: Boven E; Nauta M M; Schlüper H M; Erkelens C A; Pinedo H M
Superior efficacy of trimelamol to hexamethylmelamine in human ovarian cancer xenografts.
Cancer chemotherapy and pharmacology 1986;18(2):124-8.
1986: Verweij J; Stuurman M; de Vries J; Pinedo H M
The difference in pharmacokinetics of mitomycin C, given either as a single agent or as a part of combination chemotherapy.
Journal of cancer research and clinical oncology 1986;112(3):283-4.
1986: Peters G J; van Dijk J; van Groeningen C; Laurensse E J; Leyva A; Lankelma J; Pinedo H M
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Advances in experimental medicine and biology 1986;195 Pt B():121-8.
1986: Alberto P; Rozencweig M; Clavel M; Siegenthaler P; Cavalli F; Gundersen S; Bruntsch U; Renard J; Pinedo H
Phase II study of 5'-deoxy-5-fluorouridine (doxifluridine) in advanced malignant melanoma.
Cancer chemotherapy and pharmacology 1986;16(1):78-9.
1986: Van Maanen J M; De Ruiter C; Kootstra P R; De Vries J; Pinedo H M
Free radical formation from the antineoplastic agent VP 16-213.
Free radical research communications 1986;1(4):263-72.
1986: Peters G J; Laurensse E; Leyva A; Pinedo H M
Modulation of cytotoxicity and metabolism of 5-fluorouracil in two intestine cell lines.
Advances in experimental medicine and biology 1986;195 Pt B():113-20.
1985: Verweij J; Kester D M; Breed W P; Hillen H F; Pinedo H M
The absence of influence of acetylsalicylic acid (ASA) on the transient decrease in platelet counts observed after infusion of bleomycin and vinblastine.
European journal of cancer & clinical oncology 1985;21(12):1471-4.
1985: de Bruijn E A; van Oosterom A T; Tjaden U R; Reeuwijk H J; Pinedo H M
Pharmacology of 5'-deoxy-5-fluorouridine in patients with resistant ovarian cancer.
Cancer research 1985;45(11 Pt 2):5931-5.
1985: Boven E; Nauta M M; Schluper H M; Elferink F; van der Vijgh W J; Pinedo H M
Secondary screening of platinum compounds in human ovarian cancer xenografts in nude mice.
European journal of cancer & clinical oncology 1985;21(10):1253-60.
1985: van Maanen J M; de Ruiter C; Kootstra P R; Lafleur M V; de Vries J; Retèl J; Pinedo H M
Inactivation of phi X174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213.
European journal of cancer & clinical oncology 1985;21(10):1215-8.
1985: van Maanen J M; de Ruiter C; de Vries J; Kootstra P R; Gobas F; Pinedo H M
The role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins.
European journal of cancer & clinical oncology 1985;21(9):1099-106.
1985: Van der Vijgh W J; Verbeek P C; Klein I; Pinedo H M
Biliary excretion of platinum in rats after administration of cisplatin and aqua(1,1-bis(aminomethyl)-cyclohexane)sulfatoplatinum(II) (spiroplatin, TNO-6).
Cancer letters 1985;28(1):103-9.
1985: Elferink F; van der Vijgh W J; Pinedo H M
Analysis of antitumour [1,1-bis(aminomethyl)cyclohexane]platinum(II) complexes derived from spiroplatin by high-performance liquid chromatography with differential pulse amperometric detection.
Journal of chromatography 1985;320(2):379-92.
1985: Boven E; van der Vijgh W J; Nauta M M; Schlüper H M; Pinedo H M
Comparative activity and distribution studies of five platinum analogues in nude mice bearing human ovarian carcinoma xenografts.
Cancer research 1985;45(1):86-90.
1985: den Hartigh J; Voortman G; van Oort W J; Weenen H; Pinedo H M
Handling of biological samples in the determination of the anti-neoplastic drug mitomycin C.
Journal of pharmaceutical and biomedical analysis 1985;3(5):417-23.
1985: Verwey J; Slater R; Kamphorst W; Pinedo H M
Neuroepithelioma (neuroblastoma) arising in an adult. A case report.
Journal of cancer research and clinical oncology 1985;110(2):165-9.
1985: Keizer H J; Pinedo H M
Cancer chemotherapy: alternative routes of drug administration. A review.
Cancer drug delivery 1985;2(2):147-69.
1985: Holdener E E; Hansen H H; Høst H; Bruntsch U; Cavalli F; Renard J; Pinedo H M; Rozencweig M
Epirubicin in colorectal cancer. A phase II study of the early clinical trials group (EORTC).
Investigational new drugs 1985;3(1):63-6.
1985: Peters G J; Laurensse E; Leyva A; Pinedo H M
The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites.
The International journal of biochemistry 1985;17(1):95-9.
1984: Uitendaal M P; Schornagel J H; Leyva A; Pinedo H M
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.
European journal of cancer & clinical oncology 1984;20(12):1527-32.
1984: Leyva A; van Groeningen C J; Kraal I; Gall H; Peters G J; Lankelma J; Pinedo H M
Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.
Cancer research 1984;44(12 Pt 1):5928-33.
1984: Verwey J; Boven E; van der Meulen J; Pinedo H M
Recovery from mitomycin C-induced hemolytic uremic syndrome. A case report.
Cancer 1984;54(12):2878-81.
1984: Elferink F; Van der Vijgh W J; Van der Poort S E; Henzen-Logmans S C; Pinedo H M
Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats.
Cancer letters 1984;25(1):61-9.
1984: Peters G J; Laurensse E; Lankelma J; Leyva A; Pinedo H M
Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars.
European journal of cancer & clinical oncology 1984;20(11):1425-31.
1984: van der Vijgh W J; Elferink F; Postma G J; Vermorken J B; Pinedo H M
Determination of ethylenediamineplatinum(II) malonate in infusion fluids, human plasma and urine by high-performance liquid chromatography.
Journal of chromatography 1984;310(2):335-42.
1984: Stoter G; Vendrik C P; Struyvenberg A; Sleyfer D T; Vriesendorp R; Schraffordt Koops H; van Oosterom A T; ten Bokkel Huinink W W; Pinedo H M
Five-year survival of patients with disseminated nonseminomatous testicular cancer treated with cisplatin, vinblastine, and bleomycin.
Cancer 1984;54(8):1521-4.
1984: Leyva A; Appel H; Pinedo H M
Diverse deoxyribonucleotide profiles in cultured human cells with differential sensitivity to thymidine.
Cancer biochemistry biophysics 1984;7(3):231-7.
1984: Weenen H; van Maanen J M; de Planque M M; McVie J G; Pinedo H M
Metabolism of 4'-modified analogs of doxorubicin. unique glucuronidation pathway for 4'-epidoxorubicin.
European journal of cancer & clinical oncology 1984;20(7):919-26.
1984: Weenen H; Pinedo H M; de Planque M M; Ten Bokkel Huinink W W; McVie J G; Lankelma J
Pharmacokinetics of carminomycin in man: biweekly schedule vs single dose every three weeks.
European journal of cancer & clinical oncology 1984;20(7):915-8.
1984: Neijt J P; ten Bokkel Huinink W W; van der Burg M E; van Oosterom A T; Vriesendorp R; Pinedo H M
Current status of systemic chemotherapy in the treatment of advanced ovarian cancer with emphasis on CHAP-5.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1984;2(1):19-29.
1984: Peters G J; Kraal I; Laurensse E; Leyva A; Pinedo H M
Separation of 5-fluorouracil and uracil by ion-pair reversed-phase high-performance liquid chromatography on a column with porous polymeric packing.
Journal of chromatography 1984;307(2):464-8.
1984: Pinedo H M; Bramwell V H; Mouridsen H T; Somers R; Vendrik C P; Santoro A; Buesa J; Wagener T; van Oosterom A T; van Unnik J A
Cyvadic in advanced soft tissue sarcoma: a randomized study comparing two schedules. A study of the EORTC Soft Tissue and Bone Sarcoma Group.
Cancer 1984;53(9):1825-32.
1984: Peters G J; Laurensse E; Leyva A; Pinedo H M
Fluctuations in phosphoribosyl pyrophosphate levels in monolayer tumor cell lines. Effects of drugs.
FEBS letters 1984;170(2):277-80.
1984: Leyva A; Appel H; Kraal I; Pinedo H M
Differential metabolism of thymidine in human lymphoid and melanoma cells in vitro.
Anticancer research 1984;4(3):173-8.
1984: Neijt J P; ten Bokkel Huinink W W; van der Burg M E; van Oosterom A T; Kooyman C D; van Houwelingen J C; Pinedo H M
Combination chemotherapy with or without hexamethylmelamine in alkylating-agent resistant ovarian carcinoma.
Cancer 1984;53(7):1467-72.
1984: Schornagel J H; Leyva A; Pinedo H M
Methotrexate with thymidine protection or rescue in advanced head and neck cancer: a phase II study.
Cancer treatment reports 1984;68(3):543-5.
1984: Vermorken J B; van der Vijgh W J; Klein I; Hart A A; Gall H E; Pinedo H M
Pharmacokinetics of free and total platinum species after short-term infusion of cisplatin.
Cancer treatment reports 1984;68(3):505-13.
1984: Boven E; Stolk J G; Tierie A H; Pinedo H M
[Ovarian carcinoma: a multidisciplinary approach]
Nederlands tijdschrift voor geneeskunde 1984;128(3):126-31.
1984: Keizer H J; Karim A B; Njo K H; Tierie A H; Snow G B; Vermorken J B; Pinedo H M
Feasibility study on daily administration of cis-diamminedichloroplatinum(II) in combination with radiotherapy.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1984;1(3):227-34.
1984: Boven E; Vermorken J B; van Slooten H; Pinedo H M
Complete response of metastasized adrenal cortical carcinoma with o,p'-DDD. Case report and literature review.
Cancer 1984;53(1):26-9.
1984: Leyva A; Schornagel J H; Kraal I; Wadman S K; Pinedo H M
Clinical and biochemical studies of high-dose thymidine treatment in patients with solid tumors.
Journal of cancer research and clinical oncology 1984;107(3):211-6.
1984: Uitendaal M P; Schornagel J H; Leyva A; Pinedo H M
Synergism between purines and thymidine (TDR) in reversal of methotrexate (MTX) toxicity in mice using continuous infusions.
Advances in experimental medicine and biology 1984;165 Pt B():401-5.
1984: Leyva A; Appel H; Pinedo H M
Thymidine sensitivity and deoxynucleotide pools of human lymphoid and melanoma cells in vitro.
Advances in experimental medicine and biology 1984;165 Pt B():389-93.
1984: Leyva A; Kraal I; Lankelma J; Pinedo H M
High uridine catabolic activity in cultured human melanoma cells.
Advances in experimental medicine and biology 1984;165 Pt B():395-9.
1984: Golding R P; Smith F W; Schröder F H; Pinedo H M
Clinical usefulness of nuclear magnetic resonance (NMR). Case report and summary of current applications.
The Netherlands journal of medicine 1984;27(3):80-3.
1983: den Hartigh J; McVie J G; van Oort W J; Pinedo H M
Pharmacokinetics of mitomycin C in humans.
Cancer research 1983;43(10):5017-21.
1983: Leyva A; Kraal I; Lankelma J; Delemarre J F; Pinedo H M
High uridine phosphorylase activity in human melanoma tumor.
Anticancer research 1983;3(4):227-31.
1983: Uitendaal M P; Hubers H A; McVie J G; Pinedo H M
Human tumour clonogenicity in agar is improved by cell-free ascites.
British journal of cancer 1983;48(1):55-9.
1983: Høst H; Joss R; Pinedo H; Bruntsch U; Cavalli F; Renard G; van Glabbeke M; Rozencweig M
Phase II trial of diaziquone (AZQ) in advanced malignant melanoma.
European journal of cancer & clinical oncology 1983;19(2):295-8.
1983: Vermorken J B; Kapteijn T S; Hart A A; Pinedo H M
Ototoxicity of cis-diamminedichloroplatinum (II): influence of dose, schedule and mode of administration.
European journal of cancer & clinical oncology 1983;19(1):53-8.
1983: Holthuis J J; Römkens F M; Pinedo H M; van Oort W J
Plasma assay for the antineoplastic agent VP 16-213 (etoposide) using high-performance liquid chromatography with electrochemical detection.
Journal of pharmaceutical and biomedical analysis 1983;1(1):89-97.
1983: Pinedo H M; Karim A B; van Vliet W H; Snow G B; Vermorken J B
Daily cis-dichlorodiammineplatinum (II) as a radio-enhancer: a preliminary toxicity report.
Journal of cancer research and clinical oncology 1983;105(1):79-82.
1983: Pinedo H M; Keizer H J
Potentials of pharmacokinetic studies in cancer chemotherapy.
Progress in clinical and biological research 1983;132E():121-8.
1983: Weenen H; Lankelma J; Penders P G; McVie J G; ten Bokkel Huinink W W; de Planque M M; Pinedo H M
Pharmacokinetics of 4'-epi-doxorubicin in man.
Investigational new drugs 1983;1(1):59-64.
1983: Boven E; Pinedo H M
Two patients with a fatal haemolytic-uremic syndrome after combination therapy including mitomycin C.
The Netherlands journal of medicine 1983;26(9):288.
1983: Boven E; Pinedo H M
Mitomycin C: interstitial pneumonitis and haemolytic-uraemic syndrome.
The Netherlands journal of medicine 1983;26(6):153-6.
1982: Lankelma J; Laurensse E; Pinedo H M
A flow-through tissue culture system with fast dynamic response.
Analytical biochemistry 1982;127(2):340-5.
1982: Schornagel J H; Leyva A; Pinedo H M
Is there a role for thymidine in cancer chemotherapy?
Cancer treatment reviews 1982;9(4):331-52.
1982: Vermorken J B; van der Vijgh W J; Klein I; Gall H E; Pinedo H M
Pharmacokinetics of free platinum species following rapid, 3-hr and 24-hr infusions of cis-diamminedichloroplatinum (II) and its therapeutic implications.
European journal of cancer & clinical oncology 1982;18(11):1069-74.
1982: Van Maanen J M; Van Oort W J; Pinedo H M
In vitro and in vivo metabolism of VP 16-213 in the rat.
European journal of cancer & clinical oncology 1982;18(9):885-90.
1982: Lankelma J; Penders P G; McVie J G; Leyva A; Ten Bokkel-Huinink W W; de Planque M M; Pinedo H M
Plasma concentrations of carminomycin and carminomycinol in man, measured by high pressure liquid chromatography.
European journal of cancer & clinical oncology 1982;18(4):363-7.
1982: Leyva A; Appel H; Pinedo H M
Purine modulation of thymidine activity in L1210 leukemia cells in vitro.
Leukemia research 1982;6(4):483-90.
1982: Vermorken J B; Pinedo H M
Gastrointestinal toxicity of cis-diamminedichloroplatinum (II).
The Netherlands journal of medicine 1982;25(8):270-4.
1982: Vermorken J B; Pinedo H M
Gastrointestinal toxicity of cis-diamminedichloroplatinum (II).
The Netherlands journal of medicine 1982;25(8):275-9.
1981: Lankelma J; Penders P G; Leyva A; Kleeberg U R; Kenny J B; Bramwell V; McVie J G; Pinedo H M
Concentrations of N-(phosphonacetyl)-L-aspartate (PALA) in plasma and tears in man.
European journal of cancer & clinical oncology 1981;17(11):1199-204.
1981: Sylvester R J; Pinedo H M; De Pauw M; Staquet M J; Buyse M E; Renard J; Bonadonna G
Quality of institutional participation in multicenter clinical trials.
The New England journal of medicine 1981;305(15):852-5.
1981: Leyva A; Appel H; Smith P; Lankelma J; Pinedo H M
Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro.
Cancer letters 1981;12(1-2):169-73.
1981: Lankelma J; Penders P G; Leyva A; Pinedo H M
Determination of thioproline in plasma using high performance liquid chromatography.
Cancer letters 1981;12(1-2):131-7.
1981: Nederbragt H; Uitendaal M P; van der Grint L; Leyva A; Pinedo H M
Reversal of methotrexate inhibition of colony growth of L1210 leukemia cells in semisolid medium.
Cancer research 1981;41(3):1193-8.
1981: Leyva A; Nederbragt H; Lankelma J; Pinedo H M
Methotrexate cytotoxicity: studies on its reversal by folates and nucleosides.
Cancer treatment reports 1981;65 Suppl 1():45-50.
1980: Lankelma J; Penders P G; Leyva A; Pinedo H M
Determination of N-(phosphonacetyl)-L-aspartic acid (PALA) in plasma and urine by high pressure liquid chromatography.
European journal of cancer 1980;16(11):1483-7.
1980: Neijt J P; Barents J W; Vendrik C P; van Lindert A C; Struyvenberg A; Pinedo H M
[Chemotherapy of stage III and IV ovarian carcinoma]
Nederlands tijdschrift voor geneeskunde 1980;124(38):1601-5.
1980: Breed J G; Zimmerman A N; Dormans J A; Pinedo H M
Failure of the antioxidant vitamin E to protect against adriamycin-induced cardiotoxicity in the rabbit.
Cancer research 1980;40(6):2033-8.
1980: Vermorken J B; van der Vijgh W J; Pinedo H M
Pharmacokinetic evidence for an enterohepatic circulation in a patient treated with cis-dichlorodiammineplatinum (II).
Research communications in chemical pathology and pharmacology 1980;28(2):319-28.
1980: Neijt J P; van Lindert A C; Vendrik C P; Roozendaal K J; Struyvenberg A; Pinedo H M
Treatment of advanced ovarian carcinoma with a combination of hexmethylmelamine, cyclophosphamide, methotrexate, and 5-fluorourcil (hexa-CAF) in patients with and without previous treatment.
Cancer treatment reports 1980;64(2-3):323-6.
1980: van Hoesel Q G; Pinedo H M
Complete remission of mediastinal germ-cell tumors with cis-dichlorodiammineplatinum(II) combination chemotherapy.
Cancer treatment reports 1980;64(2-3):319-21.
1980: Buesa-Perez J M; Leyva A; Pinedo H M
Effect of methotrexate on 5-phosphoribosyl 1-pyrophosphate levels in L1210 leukemia cells in vitro.
Cancer research 1980;40(1):139-44.
1979: Bramwell V H; Brugarolas A; Mouridsen H T; Cheix F; De Jager F; van Oosterom A T; Vendrik C P; Pinedo H M; Sylvester R; De Pauw M
E.O.R.T.C. phase II study of cisplatin in cyvadic-resistant soft tissue sarcoma.
European journal of cancer 1979;15(12):1511-3.
1979: Breed J G; Zimmerman A N; Meyler F L; Pinedo H M
The interval-force relationship: a technique for evaluating the cardiac toxicity of anthracycline analogs.
Cancer treatment reports 1979;63(5):869-73.
1979: Pinedo H M; Vendrik C P; Bramwell V H; van Slooten E A; Deakin D P; van Unnik J A; Staquet M; Sylvester R; Bonadonna G
Evaluation of adjuvant therapy in soft tissue sarcoma. A collaborative multidisciplinary approach. E.O.R.T.C. protocol 62771.
European journal of cancer 1979;15(5):811-20.
1979: Vermeer R J; Pinedo H M
Partial remission of advanced adenoid cystic carcinoma obtained with adriamycin: a case report with a review of the literature.
Cancer 1979;43(5):1604-6.
1979: Stoter G; Sleijfer D T; Vendrik C P; Schraffordt Koops H; Struyvenberg A; Van Oosterom A T; Brouwers T M; Pinedo H M
Combination chemotherapy with cis-diammine-dichloro-platinum, vinblastine, and bleomycin in advanced testicular non-seminoma.
Lancet 1979;1(8123):941-5.
1979: Leyva A; Schornagel J; Pinedo H M
High performance liquid chromatography of plasma pyrimidines and purines and its application in cancer chemotherapy.
Advances in experimental medicine and biology 1979;122B():389-94.
1979: Neijt J P; van Lindert A C; Vendrik C P; Roozendaal K J; Struyvenberg A; Pinedo H M
Hexa-CAF combination chemotherapy and other multiple-drug regimens in advanced ovarian carcinoma: present and future.
The Netherlands journal of medicine 1979;22(2):38-44.
1979: Buesa J M; Leyva A; Pinedo H M
Increase of phosphoribosylpyrophosphate levels in cultured L1210 leukemia cells exposed to methotrexate.
Advances in experimental medicine and biology 1979;122B():351-6.
1978: Pinedo H M; Vendrik C P; Staquet M; Sylvester R
Study of cis-diammine-dichloro-platinum in advanced soft tissue sarcoma. Protocol 62781, March 1978.
European journal of cancer 1978;14(10):1149-52.
1978: Leyva A; Baygell P D; van Loenen A C; van Asten P; Pintus C; Spreafico F; Pinedo H M
Characterization of methotrexate recovered from the urine of high dose patients for the purpose of clinical re-use.
European journal of cancer 1978;14(10):1017-28.
1978: Stoter G; Vendrik C P; Struyvenberg A; Pinedo H M
[The effect of platinum diamminodichloride (cis-platinum) in the treatment of metastasized testicular teratoma]
Nederlands tijdschrift voor geneeskunde 1978;122(28):1015-20.
1978: Lindert A C; Barents J W; Pinedo H M
[The silent killer: treatment of a patient by the oncological team]
Nederlands tijdschrift voor geneeskunde 1978;122(3):65-8.
1977: Pinedo H M; Chabner B A
Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity.
Cancer treatment reports 1977;61(4):709-15.
1977: Pinedo H M; Vendrik C P; Staquet M; Kenis Y; Sylvester R
E.O.R.T.C. protocol for the therapy of metastatic soft tissue sarcoma, a randomized trial.
European journal of cancer 1977;13(7):765-71.
1977: Pinedo H M; Kenis Y
Chemotherapy of advanced soft-tissue sarcomas in adults.
Cancer treatment reviews 1977;4(2):67-86.
1977: Pinedo H M; Zaharko D S; Bull J; Chabner B A
The relative contribution of drug concentration and duration of exposure to mouse bone marrow toxicity during continuous methotrexate infusion.
Cancer research 1977;37(2):445-50.
1976: Pinedo H M; Zaharko D S; Bull J M; Chabner B A
The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides.
Cancer research 1976;36(12):4418-24.
1976: Pinedo H M; Chabner B A; Zaharko D S; Bull J M
Evidence for early recruitment of granulocyte precursors during high-dose methotrexate infusions in mice.
Blood 1976;48(2):301-7.
1976: Pinedo H M; Zaharko D S; Dedrick R L
Device for constant Sc infusion of methotrexate: plasma results in mice.
Cancer treatment reports 1976;60(7):889-93.
1974: Pinedo H M; Struyvenberg A; de Graeff J
Renovascular hypertension. Forms, clinical findings, course and therapy in cases of renal artery stenosis.
The Netherlands journal of medicine 1974;17(2):66-87.
1973: Pinedo H M; De Graeff J; Struyvenberg A
Prognosis in arteriosclerotic renovascular hypertension.
Clinical science and molecular medicine. Supplement 1973;45 Suppl 1():309s-10.

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