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Yuan Zhu

Research Profile

Chemicals & Drugs

Living Beings

Genes & Molecular Sequences

Genes, Neurofibromatosis 1

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Publications

TOP 3
Jennifer A Oliver; Luis F Parada; Jackson S Turner; Yuan Zhu; Philip E Lapinski; Beth A Lubeck; Philip D King
The Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes.
Chenran Wang; Yuan Zhu; Z Christine Bian; Chun-Chi Liang; Jun-Lin Guan
FIP200 is required for maintenance and differentiation of postnatal neural stem cells.
Yuan Wang; Kazuaki Yoshikawa; Long-Sheng Chang; Edward Kim; Bennett G Novitch; Xiaojing Wang; Yuan Zhu
ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities.

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All Publications

2013: Jennifer A Oliver; Luis F Parada; Jackson S Turner; Yuan Zhu; Philip E Lapinski; Beth A Lubeck; Philip D King
The Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes.
Molecular immunology 2013;55(3-4):292-302.
2013: Chenran Wang; Yuan Zhu; Z Christine Bian; Chun-Chi Liang; Jun-Lin Guan
FIP200 is required for maintenance and differentiation of postnatal neural stem cells.
Nature neuroscience 2013;16(5):532-42.
2012: Yuan Wang; Kazuaki Yoshikawa; Long-Sheng Chang; Edward Kim; Bennett G Novitch; Xiaojing Wang; Yuan Zhu
ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities.
Cell 2012;150(4):816-30.
2011: Mingjia Tan; Yuan Zhu; Margaret Liu; Sun-Jung Kim; Thomas L Saunders; Yongchao Zhao; Lijun Jia; Yi Sun
SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation.
Developmental cell 2011;21(6):1062-76.
2011: Susan M Huson; Maria T Acosta; Allan J Belzberg; Andre Bernards; Jonathan Chernoff; Karen Cichowski; D Gareth Evans; Rosalie E Ferner; Marco Giovannini; Bruce R Korf; Robert Listernick; Kathryn N North; Roger J Packer; Luis F Parada; Juha Peltonen; Vijaya Ramesh; Karlyne M Reilly; John W Risner; Elizabeth K Schorry; Meena Upadhyaya; David H Viskochil; Yuan Zhu; Kim Hunter-Schaedle; Filippo G Giancotti
Back to the future: proceedings from the 2010 NF Conference.
American journal of medical genetics. Part A 2011;155A(2):307-21.
2009: Yuan Wang; Jiong Yang; Huarui Zheng; Gerald J Tomasek; Peng Zhang; Paul E McKeever; Eva Y-H P Lee; Yuan Zhu
Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model.
Cancer cell 2009;15(6):514-26.
2009: Mingjia Tan; Shannon W Davis; Thomas L Saunders; Yuan Zhu; Yi Sun
RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6203-8.
2008: Yijun Cui; Rui M Costa; Geoffrey G Murphy; Ype Elgersma; Yuan Zhu; David H Gutmann; Luis F Parada; Istvan Mody; Alcino J Silva
Neurofibromin regulation of ERK signaling modulates GABA release and learning.
Cell 2008;135(3):549-60.
2008: Feng-Chun Yang; David A Ingram; Shi Chen; Yuan Zhu; Jin Yuan; Xiaohong Li; Xianlin Yang; Scott Knowles; Whitney Horn; Yan Li; Shaobo Zhang; Yanzhu Yang; Saeed T Vakili; Menggang Yu; Dennis Burns; Kent Robertson; Gary Hutchins; Luis F Parada; D Wade Clapp
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow.
Cell 2008;135(3):437-48.
2008: Nancy M Joseph; Jack T Mosher; Johanna Buchstaller; Paige Snider; Paul E McKeever; Megan S Lim; Simon J Conway; Luis F Parada; Yuan Zhu; Sean J Morrison
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells.
Cancer cell 2008;13(2):129-40.
2008: Huarui Zheng; Lou Chang; Neha Patel; Jiong Yang; Lori Lowe; Dennis K Burns; Yuan Zhu
Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation.
Cancer cell 2008;13(2):117-28.
2008: Therese Roth; Poornapriya Ramamurthy; David Muir; Margaret R Wallace; Yuan Zhu; Lou Chang; Kate F Barald
Influence of hormones and hormone metabolites on the growth of Schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(2):513-24.
2007: Mario Romero; Lu Lin; Mark E Lush; Lei Lei; Luis F Parada; Yuan Zhu
Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(8):2124-34.
2005: Yuan Zhu; Takayuki Harada; Li Liu; Mark E Lush; Frantz Guignard; Chikako Harada; Dennis K Burns; Michaela Bajenaru; David H Gutmann; Luis F Parada
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation.
Development (Cambridge, England) 2005;132(24):5577-88.
2005: Yuan Zhu; Frantz Guignard; Dawen Zhao; Li Liu; Dennis K Burns; Ralph P Mason; Albee Messing; Luis F Parada
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.
Cancer cell 2005;8(2):119-30.
2005: Luis F Parada; C-H Kwon; Yuan Zhu
Modeling neurofibromatosis type 1 tumors in the mouse for therapeutic intervention.
Cold Spring Harbor symposia on quantitative biology 2005;70():173-6.
2004: Doan T Le; Namie Kong; Yuan Zhu; Jennifer O Lauchle; Abigail Aiyigari; Benjamin S Braun; Endi Wang; Scott C Kogan; Michelle M Le Beau; Luis F Parada; Kevin Shannon
Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder.
Blood 2004;103(11):4243-50.
2004: Anat Stemmer-Rachamimov; David N Louis; G Petur Nielsen; Cristina R Antonescu; Alexander D Borowsky; Roderick T Bronson; Dennis K Burns; Pascale Cervera; Margaret E McLaughlin; Guido Reifenberger; Michael C Schmale; Mia MacCollin; Richard C Chao; Karen Cichowski; Michel Kalamarides; Shanta M Messerli; Andrea I McClatchey; Michiko Niwa-Kawakita; Nancy Ratner; Karlyne M Reilly; Yuan Zhu; Marco Giovannini
Comparative pathology of nerve sheath tumors in mouse models and humans.
Cancer research 2004;64(10):3718-24.
2004: Aaron D Gitler; Yi Kong; John K Choi; Yuan Zhu; Warren S Pear; Jonathan A Epstein
Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia.
Pediatric research 2004;55(4):581-4.
2003: Michaela Bajenaru; M Rosario Hernandez; Arie Perry; Yuan Zhu; Luis F Parada; Joel R Garbow; David H Gutmann
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.
Cancer research 2003;63(24):8573-7.
2003: Aaron D Gitler; Yuan Zhu; Fraz A Ismat; Min Min Lu; Yasutaka Yamauchi; Luis F Parada; Jonathan A Epstein
Nf1 has an essential role in endothelial cells.
Nature genetics 2003;33(1):75-9.
2002: Yuan Zhu; Luis F Parada
The molecular and genetic basis of neurological tumours.
Nature reviews. Cancer 2002;2(8):616-26.
2002: Michaela Bajenaru; Yuan Zhu; Nicolé M Hedrick; Jessica Donahoe; Luis F Parada; David H Gutmann
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.
Molecular and cellular biology 2002;22(14):5100-13.
2002: Yuan Zhu; Pritam Ghosh; Patrick Charnay; Dennis K Burns; Luis F Parada
Neurofibromas in NF1: Schwann cell origin and role of tumor environment.
Science (New York, N.Y.) 2002;296(5569):920-2.
2001: David H Gutmann; Y L Wu; Nicolé M Hedrick; Yuan Zhu; Abhijit Guha; Luis F Parada
Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes.
Human molecular genetics 2001;10(26):3009-16.
2001: Yuan Zhu; Mario Romero; P Ghosh; Z Ye; Patrick Charnay; Elisabeth J Rushing; J D Marth; Luis F Parada
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain.
Genes & development 2001;15(7):859-76.
2001: Yuan Zhu; Luis F Parada
A particular GAP in mind.
Nature genetics 2001;27(4):354-5.
2001: Yuan Zhu; Luis F Parada
Neurofibromin, a tumor suppressor in the nervous system.
Experimental cell research 2001;264(1):19-28.
1998: Yuan Zhu; J A Richardson; Luis F Parada; Jonathan M Graff
Smad3 mutant mice develop metastatic colorectal cancer.
Cell 1998;94(6):703-14.