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John Lee

Research Profile

Chemicals & Drugs

Physiology

Phenomena

Phosphorylation

Anatomy

Concepts & Ideas

Biological Models

Disorders

Cell Transformation, Neoplastic

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Publications

TOP 3
John Lee; Brian D Lehmann; David M Terrian; William H Chappell; Franca Stivala; Massimo Libra; Alberto M Martelli; Linda Steelman; James A McCubrey
Targeting prostate cancer based on signal transduction and cell cycle pathways.
James A McCubrey; Michele Milella; Agostino Tafuri; Alberto M Martelli; Paolo Lunghi; Antonio Bonati; Melchiorre Cervello; John Lee; Linda Steelman
Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.
John Lee; Patricia Brafford; Meenhard Herlyn
Unraveling the mysteries of IGF-1 signaling in melanoma.

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2008: John Lee; Brian D Lehmann; David M Terrian; William H Chappell; Franca Stivala; Massimo Libra; Alberto M Martelli; Linda Steelman; James A McCubrey
Targeting prostate cancer based on signal transduction and cell cycle pathways.
Cell cycle (Georgetown, Tex.) 2008;7(12):1745-62.
2008: James A McCubrey; Michele Milella; Agostino Tafuri; Alberto M Martelli; Paolo Lunghi; Antonio Bonati; Melchiorre Cervello; John Lee; Linda Steelman
Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.
Current opinion in investigational drugs (London, England : 2000) 2008;9(6):614-30.
2008: John Lee; Patricia Brafford; Meenhard Herlyn
Unraveling the mysteries of IGF-1 signaling in melanoma.
The Journal of investigative dermatology 2008;128(6):1358-60.
2008: John Lee; Linda Steelman; William H Chappell; James A McCubrey
Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells.
Cell cycle (Georgetown, Tex.) 2008;7(5):631-6.
2008: James Tsai; John Lee; Weiru Wang; Jiazhong Zhang; Hanna Cho; Shumeye Mamo; Ryan Bremer; Sam Gillette; Jun Kong; Nikolas K Haass; Katrin Sproesser; Ling Li; Keiran S M Smalley; Daniel Fong; Yong-Liang Zhu; Adhirai Marimuthu; Hoa Nguyen; Billy Lam; Jennifer Liu; Ivana Cheung; Julie Rice; Yoshihisa Suzuki; Catherine Luu; Calvin Settachatgul; Rafe Shellooe; John Cantwell; Sung-Hou Kim; Joseph Schlessinger; Kam Y J Zhang; Brian L West; Ben Powell; Gaston Habets; Chao Zhang; Prabha N Ibrahim; Peter Hirth; Dean R Artis; Meenhard Herlyn; Gideon Bollag
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):3041-6.
2007: John Lee; Meenhard Herlyn
Old disease, new culprit: tumor stem cells in cancer.
Journal of cellular physiology 2007;213(3):603-9.
2007: John Lee; Meenhard Herlyn
Microenvironmental influences in melanoma progression.
Journal of cellular biochemistry 2007;101(4):862-72.
2007: Keiran Smalley; Rooha Contractor; Nikolas K Haass; John Lee; Katherine L Nathanson; C Angelina Medina; Keith T Flaherty; Meenhard Herlyn
Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels.
British journal of cancer 2007;96(3):445-9.
2006: John Lee; Meenhard Herlyn
Embryogenesis meets tumorigenesis.
Nature medicine 2006;12(8):882-4.
2006: James A McCubrey; Linda Steelman; Steven L Abrams; John Lee; Fumin Chang; Fred E Bertrand; Patrick M Navolanic; David M Terrian; Richard A Franklin; Antonio B D'Assoro; Jeffrey Salisbury; Maria Clorinda Mazzarino; Franca Stivala; Massimo Libra
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.
Advances in enzyme regulation 2006;46():249-79.
2005: John Lee; Linda Steelman; James A McCubrey
Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells.
International journal of oncology 2005;26(6):1637-44.
2004: John Lee; Linda Steelman; James A McCubrey
Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells.
Cancer research 2004;64(22):8397-404.
2004: John G Shelton; Fumin Chang; John Lee; Richard A Franklin; Linda Steelman; James A McCubrey
B-raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells.
Cell cycle (Georgetown, Tex.) 2004;3(2):189-96.
2003: Patrick M Navolanic; John Lee; James A McCubrey
Docetaxel cytotoxicity is enhanced by inhibition of the Raf/MEK/ERK signal transduction pathway.
Cancer biology & therapy 2003;2(6):677-8.
2003: John G Shelton; Phillip W Moye; Linda Steelman; William L Blalock; John Lee; Richard A Franklin; Martin McMahon; James A McCubrey
Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.
Leukemia 2003;17(9):1765-82.
2003: Fumin Chang; Linda Steelman; John Lee; John G Shelton; Patrick M Navolanic; William L Blalock; Richard A Franklin; James A McCubrey
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.
Leukemia 2003;17(7):1263-93.
2003: John Lee; James A McCubrey
BAY-43-9006 Bayer/Onyx.
Current opinion in investigational drugs (London, England : 2000) 2003;4(6):757-63.
2003: William L Blalock; Patrick M Navolanic; Linda Steelman; John G Shelton; Phillip W Moye; John Lee; Richard A Franklin; A Mirza; Martin McMahon; Martyn K White; James A McCubrey
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
Leukemia 2003;17(6):1058-67.
2003: John G Shelton; Linda Steelman; John Lee; Steven L Knapp; William L Blalock; Phillip W Moye; Richard A Franklin; Steven C Pohnert; Amer M Mirza; Martin McMahon; James A McCubrey
Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.
Oncogene 2003;22(16):2478-92.
2003: Fumin Chang; John Lee; Patrick M Navolanic; Linda Steelman; John G Shelton; William L Blalock; Richard A Franklin; James A McCubrey
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.
Leukemia 2003;17(3):590-603.
2003: Fumin Chang; Linda Steelman; John G Shelton; John Lee; Patrick M Navolanic; William L Blalock; Richard Franklin; James A McCubrey
Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).
International journal of oncology 2003;22(3):469-80.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Elucidation of signal transduction pathways by retroviral infection of cells with modified oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;218():221-52.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Elucidation of signal transduction pathways by transfection of cells with modified oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;218():203-20.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Fibroblastic, hematopoietic, and hormone responsive epithelial cell lines and culture conditions for elucidation of signal transduction and drug resistance pathways by gene transfer.
Methods in molecular biology (Clifton, N.J.) 2003;218():185-201.
2002: John Lee; James A McCubrey
Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies.
Expert opinion on therapeutic targets 2002;6(6):659-78.
2002: Christopher J Howe; Michelle M LaHair; Jill A Maxwell; John Lee; Penni J Robinson; Oswaldo Rodriguez-Mora; James A McCubrey; Richard A Franklin
Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes.
The Journal of biological chemistry 2002;277(34):30469-76.
2002: John Lee; James A McCubrey
The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia.
Leukemia 2002;16(4):486-507.
2001: James A McCubrey; William L Blalock; Oussama A Saleh; M Pearce; Carlo Burrows; Linda Steelman; John Lee; Richard A Franklin; Stephanie M Oberhaus; Phillip W Moye; Parul D Doshi; John P McKearn
Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells.
Leukemia 2001;15(8):1203-16.
2001: William L Blalock; M Pearce; Fumin Chang; John Lee; Steven C Pohnert; Carlo Burrows; Linda Steelman; Richard A Franklin; Martin McMahon; James A McCubrey
Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells.
Leukemia 2001;15(5):794-807.
2001: James A McCubrey; John Lee; Linda Steelman; William L Blalock; Phillip W Moye; Fumin Chang; M Pearce; John G Shelton; Martyn K White; Richard A Franklin; Steven C Pohnert
Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells.
Cancer detection and prevention 2001;25(4):375-93.
2001: James A McCubrey; Linda Steelman; William L Blalock; John Lee; Phillip W Moye; Fumin Chang; M Pearce; John G Shelton; Martyn K White; Richard A Franklin; Steven C Pohnert
Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.
Advances in enzyme regulation 2001;41():289-323.
2000: Caroline R Weinstein-Oppenheimer; Linda Steelman; P A Algate; William L Blalock; Carlo Burrows; PE Hoyle; John Lee; Phillip W Moye; John G Shelton; Richard Franklin; James A McCubrey
Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells.
Leukemia 2000;14(11):1921-38.