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Thomas Wang

Research Profile

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Gastrointestinal Endoscopes

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Mouse

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Optics and Photonics

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Matthew B Sturm; D Kim Turgeon; Henry D Appelman; David G Beer; Badih Joseph Elmunzer; Bishnu P Joshi; Supang Khondee; Richard S Kwon; Shaoying Lu; Cyrus R Piraka; Thomas D Wang
Targeted Imaging of Esophageal Neoplasia with a Fluorescently Labeled Peptide: First-in-Human Results.
Zhongyao Liu; Sharon J Miller; Bishnu P Joshi; Thomas D Wang
In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptide.
Zhen Qiu; Xiyu Duan; Bishnu Joshi; Supang Khondee; Katsuo Kurabayashi; Zhongyao Liu; Michael J Mandella; Kenn Oldham; Thomas D Wang
Targeted vertical cross-sectional imaging with handheld near-infrared dual axes confocal fluorescence endomicroscope.

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All Publications

2013: Matthew B Sturm; D Kim Turgeon; Henry D Appelman; David G Beer; Badih Joseph Elmunzer; Bishnu P Joshi; Supang Khondee; Richard S Kwon; Shaoying Lu; Cyrus R Piraka; Thomas D Wang
Targeted Imaging of Esophageal Neoplasia with a Fluorescently Labeled Peptide: First-in-Human Results.
Science translational medicine 2013;5(184):184ra61.
2013: Zhongyao Liu; Sharon J Miller; Bishnu P Joshi; Thomas D Wang
In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptide.
Gut 2013;62(3):395-403.
2013: Zhen Qiu; Xiyu Duan; Bishnu Joshi; Supang Khondee; Katsuo Kurabayashi; Zhongyao Liu; Michael J Mandella; Kenn Oldham; Thomas D Wang
Targeted vertical cross-sectional imaging with handheld near-infrared dual axes confocal fluorescence endomicroscope.
Biomedical optics express 2013;4(2):322-30.
2013: Supang Khondee; Thomas D Wang
Progress in molecular imaging in endoscopy and endomicroscopy for cancer imaging.
Journal of healthcare engineering 2013;4(1):1-22.
2013: Eva M Sevick-Muraca; Thomas D Wang; Walter J Akers; Christopher H Contag; Cathy S Cutler; Bishnu P Joshi; Gary D Luker; Lawrence J Marnett; Ali Azhdarinia
Advancing the translation of optical imaging agents for clinical imaging.
Biomedical optics express 2013;4(1):160-70.
2012: Bishnu P Joshi; Cameron M Lee; Sharon J Miller; Eric J Seibel; Thomas D Wang
Multispectral endoscopic imaging of colorectal dysplasia in vivo.
Gastroenterology 2012;143(6):1435-7.
2012: Bishnu P Joshi; Zhongyao Liu; Henry D Appelman; Sakib F Elahi; Thomas D Wang
Near-infrared-labeled peptide multimer functions as phage mimic for high affinity, specific targeting of colonic adenomas in vivo (with videos).
Gastrointestinal endoscopy 2012;76(6):1197-206.e1-5.
2012: Sharon J Miller; Alnawaz Rehemtulla; Brian D Ross; Eric R Fearon; Ying Feng; Craig J Galban; Kevin A Heist; Thomas D Wang
Multimodal imaging of growth and rapamycin-induced regression of colonic adenomas in apc mutation-dependent mouse.
Translational oncology 2012;5(5):313-20.
2012: Wen-Jie Zhang; Jian-Bao Zheng; Arun Budha; Ying-Chun Hou; Yan-Xia Sui; Xue-Jun Sun; Thomas D Wang; Shao-Ying Lu
Affinity peptide developed by phage display selection for targeting gastric cancer.
World journal of gastroenterology : WJG 2012;18(17):2053-60.
2012: Sharon J Miller; Eric J Seibel; Adam Gaustad; Bishnu P Joshi; Cameron M Lee; Thomas D Wang
Targeted detection of murine colonic dysplasia in vivo with flexible multispectral scanning fiber endoscopy.
Journal of biomedical optics 2012;17(2):021103.
2012: Wibool Piyawattanametha; Zhen Qiu; Hyejun Ra; Olav Solgaard; Thomas D Wang; Shai Friedland; Gordon S Kino; Jonathan T C Liu; Kevin Loewke; Michael J Mandella; Christopher H Contag
In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract.
Journal of biomedical optics 2012;17(2):021102.
2012: Nastaran Safdarian; Henry D Appelman; Timothy T Nostrant; Zhongyao Liu; Thomas D Wang; Xiaoming Zhou; Emily T Wang
Quantifying human eosinophils using three-dimensional volumetric images collected with multiphoton fluorescence microscopy.
Gastroenterology 2012;142(1):15-20.e1.
2011: Sakib F Elahi; Richard S Kwon; Zhongyao Liu; Gary D Luker; Kathryn E Luker; Thomas D Wang
Longitudinal molecular imaging with single cell resolution of disseminated ovarian cancer in mice with a LED-based confocal microendoscope.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2011;13(6):1157-62.
2011: Sakib F Elahi; Thomas D Wang
Future and advances in endoscopy.
Journal of biophotonics 2011;4(7-8):471-81.
2011: Nastaran Safdarian; Zhongyao Liu; Thomas D Wang; Emily T Wang
Identification of nasal eosinophils using two-photon excited fluorescence.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2011;106(5):394-400.
2011: Sarah Yentz; Thomas D Wang
Molecular imaging for guiding oncologic prognosis and therapy in esophageal adenocarcinoma.
Hospital practice (1995) 2011;39(2):97-106.
2011: Sakib F Elahi; Sharon J Miller; Bishnu Joshi; Thomas D Wang
Targeted imaging of colorectal dysplasia in living mice with fluorescence microendoscopy.
Biomedical optics express 2011;2(4):981-6.
2011: Sharon J Miller; Bishnu P Joshi; Ying Feng; Adam Gaustad; Eric R Fearon; Thomas D Wang
In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe.
PloS one 2011;6(3):e17384.
2010: Thomas D Wang
Targeted, multimodality PET-CT and optical imaging platform for visualizing biological function.
Gastroenterology 2010;139(5):1790-1.
2010: Meng Li; Constantinos P Anastassiades; Bishnu Joshi; Chris M Komarck; Cyrus R Piraka; Badih J Elmunzer; D Kim Turgeon; Timothy D Johnson; Henry D Appelman; David G Beer; Thomas D Wang
Affinity peptide for targeted detection of dysplasia in Barrett's esophagus.
Gastroenterology 2010;139(5):1472-80.
2010: Thomas D Wang
Targeted imaging of flat and depressed colonic neoplasms.
Gastrointestinal endoscopy clinics of North America 2010;20(3):579-83.
2010: Thomas D Wang
Switching on the light to see more disease.
Gastroenterology 2010;138(7):2553-4.
2010: Meng Li; Xin Qin; Xiaochang Xue; Cun Zhang; Zhen Yan; Wei Han; Chris Komarck; Thomas D Wang; Yingqi Zhang
Safety evaluation and pharmacokinetics of a novel human tumor necrosis factor-alpha exhibited a higher antitumor activity and a lower systemic toxicity.
Anti-cancer drugs 2010;21(3):243-51.
2010: Martin Goetz; Thomas D Wang
Molecular imaging in gastrointestinal endoscopy.
Gastroenterology 2010;138(3):828-33.e1.
2009: Mark A Mackanos; John Hargrove; Rolf Wolters; Christine B Du; Shai Friedland; Roy M Soetikno; Christopher H Contag; May R Arroyo; James M Crawford; Thomas D Wang
Use of an endoscope-compatible probe to detect colonic dysplasia with Fourier transform infrared spectroscopy.
Journal of biomedical optics 2009;14(4):044006.
2009: Meng Li; Thomas D Wang
Targeted endoscopic imaging.
Gastrointestinal endoscopy clinics of North America 2009;19(2):283-98.
2009: Geoffrey A Sonn; Kathleen E Mach; Kristin Jensen; Pei-Lin Hsiung; Sha-Nita Jones; Christopher H Contag; Thomas D Wang; Joseph C Liao
Fibered confocal microscopy of bladder tumors: an ex vivo study.
Journal of endourology / Endourological Society 2009;23(2):197-201.
2009: Thomas D Wang
A novel capsule endoscope: do we need new kids on the block?
Gastrointestinal endoscopy 2009;69(2):260-1.
2009: S Lu; Anson W Lowe; George Triadafilopoulos; Pei-Lin Hsiung; Y Hao; J M Crawford; Thomas D Wang
Endoscopic evaluation of esophago-gastro-jejunostomy in rat model of Barrett's esophagus.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E 2009;22(4):323-30.
2008: Ian M Thompson; Donna Pauler Ankerst; Ruth Etzioni; Thomas D Wang
It's time to abandon an upper limit of normal for prostate specific antigen: assessing the risk of prostate cancer.
The Journal of urology 2008;180(4):1219-22.
2008: Hyejun Ra; Wibool Piyawattanametha; Michael J Mandella; Pei-Lin Hsiung; Jonathan Hardy; Thomas D Wang; Christopher H Contag; Gordon S Kino; Olav Solgaard
Three-dimensional in vivo imaging by a handheld dual-axes confocal microscope.
Optics express 2008;16(10):7224-32.
2008: Jonathan T C Liu; Michael J Mandella; James M Crawford; Christopher H Contag; Thomas D Wang; Gordon S Kino
Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architecture.
Journal of biomedical optics 2008;13(3):034020.
2008: Pei-Lin Hsiung; Pei-Lei Hsiung; Jonathan Hardy; Shai Friedland; Roy Soetikno; Christine B Du; Amy P Wu; Peyman Sahbaie; James M Crawford; Anson W Lowe; Christopher H Contag; Thomas D Wang
Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy.
Nature medicine 2008;14(4):454-8.
2008: Shaoying Lu; Thomas D Wang
In vivo cancer biomarkers of esophageal neoplasia.
Cancer biomarkers : section A of Disease markers 2008;4(6):341-50.
2008: Pei-Lin Hsiung; Thomas D Wang
In vivo biomarkers for targeting colorectal neoplasms.
Cancer biomarkers : section A of Disease markers 2008;4(6):329-40.
2008: Thomas D Wang
Targeted imaging of neoplasia in the digestive tract.
Cancer biomarkers : section A of Disease markers 2008;4(6):285-6.
2007: Thomas D Wang; Shai Friedland; Peyman Sahbaie; Roy Soetikno; Pei-Lin Hsiung; Jonathan T C Liu; James M Crawford; Christopher H Contag
Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathology.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007;5(11):1300-5.
2007: Thomas D Wang; George Triadafilopoulos; James M Crawford; Lisa R Dixon; Tarun Bhandari; Peyman Sahbaie; Shai Friedland; Roy Soetikno; Christopher H Contag
Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15864-9.
2007: Larry K Wong; Michael J Mandella; Gordon S Kino; Thomas D Wang
Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture.
Optics letters 2007;32(12):1674-6.
2007: Jonathan T C Liu; Michael J Mandella; Hyejun Ra; Larry K Wong; Olav Solgaard; Gordon S Kino; Wibool Piyawattanametha; Christopher H Contag; Thomas D Wang
Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner.
Optics letters 2007;32(3):256-8.
2007: Gary J Kelloff; Daniel C Sullivan; Houston Baker; Lawrence P Clarke; Robert Nordstrom; James L Tatum; Gary S Dorfman; Paula Jacobs; Christine D Berg; Martin G Pomper; Michael J Birrer; Margaret Tempero; Howard R Higley; Brenda Gumbs Petty; Caroline C Sigman; Carlo Maley; Prateek Sharma; Adam Wax; Gregory G Ginsberg; Andrew J Dannenberg; Ernest T Hawk; Edward M Messing; H Barton Grossman; Mukesh Harisinghani; Irving J Bigio; Donna Griebel; Donald E Henson; Carol J Fabian; Katherine Ferrara; Sergio Fantini; Mitchell D Schnall; Jo Anne Zujewski; Wendy Hayes; Eric A Klein; Angelo M DeMarzo; Iclal Ocak; Jeffrey A Ketterling; Clare Tempany; Faina Shtern; Howard L Parnes; Jorge Gomez; sudhir srivastava; Eva Szabo; Stephen Lam; Eric J Seibel; Pierre Massion; Geoffrey McLennan; Kevin Cleary; Robert Suh; Randall W Burt; Ruth M Pfeiffer; John M Hoffman; Hemant K Roy; Thomas D Wang; Paul J Limburg; Wafik S El-Deiry; Vali Papadimitrakopoulou; Walter N Hittelman; Calum MacAulay; Robert W Veltri; Diane Solomon; Jose Jeronimo; Rebecca Richards-Kortum; Karen A Johnson; Jaye L Viner; Steven P Stratton; Milind Rajadhyaksha; Atam Dhawan
Workshop on imaging science development for cancer prevention and preemption.
Cancer biomarkers : section A of Disease markers 2007;3(1):1-33.
2006: Jonathan T C Liu; Michael J Mandella; Shai Friedland; Roy Soetikno; James M Crawford; Christopher H Contag; Gordon S Kino; Thomas D Wang
Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia.
Journal of biomedical optics 2006;11(5):054019.
2005: Olga Kovbasnjuk; Rakhilya Mourtazina; Boris Baibakov; Thomas D Wang; Christian G Elowsky; Michael A Choti; Anne Kane; Mark Donowitz
The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19087-92.
2005: Thomas D Wang
Confocal microscopy from the bench to the bedside.
Gastrointestinal endoscopy 2005;62(5):696-7.
2005: Thomas D Wang; George Triadafilopoulos
Autofluorescence imaging: have we finally seen the light?
Gastrointestinal endoscopy 2005;61(6):686-8.
2004: Thomas D Wang; Jacques Van Dam
Optical biopsy: a new frontier in endoscopic detection and diagnosis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2004;2(9):744-53.
2004: Thomas D Wang; Christopher H Contag; Michael J Mandella; Ning Y Chan; Gordon S Kino
Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanning.
Journal of biomedical optics 2004;9(4):735-42.
2003: Thomas D Wang; Christopher H Contag; Michael J Mandella; Ning Y Chan; Gordon S Kino
Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection.
Optics letters 2003;28(20):1915-7.
2003: Thomas D Wang; Michael J Mandella; Christopher H Contag; Gordon S Kino
Dual-axis confocal microscope for high-resolution in vivo imaging.
Optics letters 2003;28(6):414-6.
2002: Stephan Brand; Thomas D Wang; Kevin T Schomacker; John M Poneros; Gregory Y Lauwers; Carolyn Corlies Compton; Marcos C Pedrosa; Norman S Nishioka
Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
Gastrointestinal endoscopy 2002;56(4):479-87.
1999: Thomas D Wang; JM Crawford; Michael S Feld; Y Wang; Irving Itzkan; Jacques Van Dam
In vivo identification of colonic dysplasia using fluorescence endoscopic imaging.
Gastrointestinal endoscopy 1999;49(4 Pt 1):447-55.
1998: Thomas D Wang; G S Janes; Y Wang; Irving Itzkan; J Van Dam; Michael S Feld
Mathematical model of fluorescence endoscopic image formation.
Applied optics 1998;37(34):8103-11.
1996: Thomas D Wang; J Van Dam; J M Crawford; Elizabeth Preisinger; Y Wang; Michael S Feld
Fluorescence endoscopic imaging of human colonic adenomas.
Gastroenterology 1996;111(5):1182-91.