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Benjamin Margolis

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Adam T Comstock; Andrea N Faris; Shyamala Ganesan; Marc B Hershenson; Benjamin L Margolis; Asamanja Chattoraj; Umadevi S Sajjan
Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1.
Toby W Hurd; Shuling Fan; Benjamin L Margolis
Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2.
Jay Pieczynski; Benjamin L Margolis
Protein complexes that control renal epithelial polarity.

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2011: Adam T Comstock; Andrea N Faris; Shyamala Ganesan; Marc B Hershenson; Benjamin L Margolis; Asamanja Chattoraj; Umadevi S Sajjan
Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1.
Journal of virology 2011;85(13):6795-808.
2011: Toby W Hurd; Shuling Fan; Benjamin L Margolis
Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2.
Journal of cell science 2011;124(Pt 5):718-26.
2011: Jay Pieczynski; Benjamin L Margolis
Protein complexes that control renal epithelial polarity.
American journal of physiology. Renal physiology 2011;300(3):F589-601.
2010: Kim-Tat Teoh; Yu-Lam Siu; Wing-Lim Chan; Marc A Schlüter; Chia-Jen Liu; J S Malik Peiris; Roberto Bruzzone; Benjamin L Margolis; Béatrice Nal
The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis.
Molecular biology of the cell 2010;21(22):3838-52.
2010: John F Dishinger; Hooi Lynn Kee; Paul M Jenkins; Shuling Fan; Toby W Hurd; Jennetta W Hammond; Yen Nhu-Thi Truong; Benjamin L Margolis; Jeffrey R Martens; Kristen J Verhey
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP.
Nature cell biology 2010;12(7):703-10.
2009: Toby W Hurd; Benjamin L Margolis
Cystin, cilia, and cysts: unraveling trafficking determinants.
Journal of the American Society of Nephrology : JASN 2009;20(12):2485-6.
2009: Marc A Schlüter; Catherine S Pfarr; Jay Pieczynski; Eileen L Whiteman; Toby W Hurd; Shuling Fan; Chia-Jen Liu; Benjamin L Margolis
Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation.
Molecular biology of the cell 2009;20(22):4652-63.
2009: Marc A Schlüter; Benjamin L Margolis
Apical lumen formation in renal epithelia.
Journal of the American Society of Nephrology : JASN 2009;20(7):1444-52.
2008: E L Whiteman; Chia-Jen Liu; Eric R Fearon; Benjamin L Margolis
The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes.
Oncogene 2008;27(27):3875-9.
2008: Jennifer L Harder; Benjamin L Margolis
SnapShot: tight and adherens junction signaling.
Cell 2008;133(6):1118, 1118.e1-2.
2008: Shirley He; Sunil K Parapuram; Toby W Hurd; Babak Behnam; Benjamin L Margolis; Anand Swaroop; Babak Behnam
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies.
Vision research 2008;48(3):366-76.
2007: Q Wang; Benjamin L Margolis
Apical junctional complexes and cell polarity.
Kidney international 2007;72(12):1448-58.
2007: Shuling Fan; Vanessa C Fogg; Qian Wang; Xiao-Wei Chen; Chia-Jen Liu; Benjamin L Margolis
A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions.
The Journal of cell biology 2007;178(3):387-98.
2007: Qian Wang; Xiao-Wei Chen; Benjamin L Margolis
PALS1 regulates E-cadherin trafficking in mammalian epithelial cells.
Molecular biology of the cell 2007;18(3):874-85.
2007: Kunyoo Shin; Qian Wang; Benjamin L Margolis
PATJ regulates directional migration of mammalian epithelial cells.
EMBO reports 2007;8(2):158-64.
2006: Samuel W Straight; Jay N Pieczynski; Eileen L Whiteman; Chia-Jen Liu; Benjamin L Margolis
Mammalian lin-7 stabilizes polarity protein complexes.
The Journal of biological chemistry 2006;281(49):37738-47.
2006: Kunyoo Shin; Benjamin L Margolis
ZOning out tight junctions.
Cell 2006;126(4):647-9.
2006: Paul M Jenkins; Toby W Hurd; Lian Zhang; Dyke P McEwen; R Lane Brown; Benjamin L Margolis; Kristen J Verhey; Jeffrey R Martens
Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17.
Current biology : CB 2006;16(12):1211-6.
2006: Kunyoo Shin; Vanessa C Fogg; Benjamin L Margolis
Tight junctions and cell polarity.
Annual review of cell and developmental biology 2006;22():207-35.
2005: Benjamin L Margolis; Jean-Paul Borg
Apicobasal polarity complexes.
Journal of cell science 2005;118(Pt 22):5157-9.
2005: Hemant Khanna; Toby W Hurd; Concepcion Lillo; Xinhua Shu; Sunil K Parapuram; Shirley He; Masayuki Akimoto; Alan F Wright; Benjamin L Margolis; David S Williams; Anand Swaroop
RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins.
The Journal of biological chemistry 2005;280(39):33580-7.
2005: Isabel J Latorre; Benjamin L Margolis; Michael H Roh; Robert S Weiss; Kristopher K Frese; Ronald T Javier
Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells.
Journal of cell science 2005;118(Pt 18):4283-93.
2005: Vanessa C Fogg; Chia-Jen Liu; Benjamin L Margolis
Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells.
Journal of cell science 2005;118(Pt 13):2859-69.
2005: Toby W Hurd; Benjamin L Margolis
Pars and polarity: taking control of Rac.
Nature cell biology 2005;7(3):205-7.
2005: Edgar Otto; Bart Loeys; Hemant Khanna; Jan Hellemans; Ralf Sudbrak; Shuling Fan; Ulla Muerb; John F O'Toole; Juliana Helou; Massimo Attanasio; Boris Utsch; John A Sayer; Concepcion Lillo; David Jimeno; Paul Coucke; Anne De Paepe; Richard Reinhardt; Sven Klages; Motoyuki Tsuda; Isao Kawakami; Takehiro Kusakabe; Heymut Omran; Anita Imm; Melissa Tippens; Pamela A Raymond; Josephine Hill; Phil Beales; Shirley He; Andreas Kispert; Benjamin L Margolis; David S Williams; Anand Swaroop; Friedhelm Hildebrandt
Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin.
Nature genetics 2005;37(3):282-8.
2005: Kunyoo Shin; Samuel W Straight; Benjamin L Margolis
PATJ regulates tight junction formation and polarity in mammalian epithelial cells.
The Journal of cell biology 2005;168(5):705-11.
2004: Shuling Fan; Toby W Hurd; Chia-Jen Liu; Samuel W Straight; Thomas Weimbs; Elizabeth A Hurd; Steven E Domino; Benjamin L Margolis
Polarity proteins control ciliogenesis via kinesin motor interactions.
Current biology : CB 2004;14(16):1451-61.
2004: Yuanhe Li; David Karnak; Borries Demeler; Benjamin L Margolis; Arnon Lavie
Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes.
The EMBO journal 2004;23(14):2723-33.
2004: Qian Wang; Toby W Hurd; Benjamin L Margolis
Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust.
The Journal of biological chemistry 2004;279(29):30715-21.
2004: Samuel W Straight; Kunyoo Shin; Vanessa C Fogg; Shuling Fan; Chia-Jen Liu; Michael H Roh; Benjamin L Margolis
Loss of PALS1 expression leads to tight junction and polarity defects.
Molecular biology of the cell 2004;15(4):1981-90.
2003: Toby W Hurd; Shuling Fan; Chia-Jen Liu; Hye Kyong Kweon; Kristina Hakansson; Benjamin L Margolis
Phosphorylation-dependent binding of 14-3-3 to the polarity protein Par3 regulates cell polarity in mammalian epithelia.
Current biology : CB 2003;13(23):2082-90.
2003: Thomas M Lanigan; Albert Liu; Yang Z Huang; Lin Mei; Benjamin L Margolis; Kun-Liang Guan
Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2048-60.
2003: Michael Hortsch; Benjamin L Margolis
Septate and paranodal junctions: kissing cousins.
Trends in cell biology 2003;13(11):557-61.
2003: Michael H Roh; Benjamin L Margolis
Composition and function of PDZ protein complexes during cell polarization.
American journal of physiology. Renal physiology 2003;285(3):F377-87.
2003: Michael H Roh; Shuling Fan; Chia-Jen Liu; Benjamin L Margolis
The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells.
Journal of cell science 2003;116(Pt 14):2895-906.
2003: Benjamin L Margolis; Isinsu Kuzu; Marille Herrmann; Michele D Raible; Eric Hsi; Serhan Alkan
Rapid polymerase chain reaction-based confirmation of cat scratch disease and Bartonella henselae infection.
Archives of pathology & laboratory medicine 2003;127(6):706-10.
2003: David A Calderwood; Yosuke Fujioka; Jose M de Pereda; Begoña García-Alvarez; Tetsuya Nakamoto; Benjamin L Margolis; C Jane McGlade; Robert C Liddington; Mark H Ginsberg
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2272-7.
2003: Toby W Hurd; Lin Gao; Michael H Roh; Ian G Macara; Benjamin L Margolis
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.
Nature cell biology 2003;5(2):137-42.
2003: Olga Makarova; Michael H Roh; Chia-Jen Liu; Stephanie Laurinec; Benjamin L Margolis
Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).
Gene 2003;302(1-2):21-9.
2002: David Karnak; Seonok Lee; Benjamin L Margolis
Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97.
The Journal of biological chemistry 2002;277(48):46730-5.
2002: Kevin M Patrie; Andrew J Drescher; Ajith Welihinda; Peter Mundel; Benjamin L Margolis
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
The Journal of biological chemistry 2002;277(33):30183-90.
2002: Albert H Kim; Hiroko Yano; Han Cho; Debra Meyer; Bob Monks; Benjamin L Margolis; Morris J Birnbaum; Moses V Chao
Akt1 regulates a JNK scaffold during excitotoxic apoptosis.
Neuron 2002;35(4):697-709.
2002: Michael H Roh; Chia-Jen Liu; Stephanie Laurinec; Benjamin L Margolis
The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions.
The Journal of biological chemistry 2002;277(30):27501-9.
2002: Michael H Roh; Olga Makarova; Chia-Jen Liu; Kunyoo Shin; Seonok Lee; Stephanie Laurinec; Meera Goyal; Roger C Wiggins; Benjamin L Margolis
The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost.
The Journal of cell biology 2002;157(1):161-72.
2002: Seonok Lee; Shuling Fan; Olga Makarova; Samuel W Straight; Benjamin L Margolis
A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia.
Molecular and cellular biology 2002;22(6):1778-91.
2001: Samuel W Straight; Lieping Chen; David Karnak; Benjamin L Margolis
Interaction with mLin-7 alters the targeting of endocytosed transmembrane proteins in mammalian epithelial cells.
Molecular biology of the cell 2001;12(5):1329-40.
2001: Kevin M Patrie; A J Drescher; Meera Goyal; Roger C Wiggins; Benjamin L Margolis
The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes.
Journal of the American Society of Nephrology : JASN 2001;12(4):667-77.
2001: Kristen J Verhey; D Meyer; R Deehan; John Blenis; Bruce J Schnapp; Tom A Rapoport; Benjamin L Margolis
Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules.
The Journal of cell biology 2001;152(5):959-70.
2001: Edward Abraham; Pierre-François Laterre; Jorge Garbino; S Pingleton; T Butler; Thierry Dugernier; Benjamin L Margolis; K Kudsk; W Zimmerli; P Anderson; Marc Reynaert; D Lew; W Lesslauer; S Passe; P Cooper; A Burdeska; M Modi; A Leighton; M Salgo; P Van der Auwera
Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients.
Critical care medicine 2001;29(3):503-10.
2000: Carolyn A Worby; Benjamin L Margolis
Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5.
Science's STKE : signal transduction knowledge environment 2000;2000(63):pe2.
2000: Helena T Mueller; Jean-Paul Borg; Benjamin L Margolis; Raymond Scott Turner
Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.
The Journal of biological chemistry 2000;275(50):39302-6.
2000: Olga Makarova; ES Kamberov; Benjamin L Margolis
Generation of deletion and point mutations with one primer in a single cloning step.
BioTechniques 2000;29(5):970-2.
2000: David Zagzag; David R Friedlander; Benjamin L Margolis; Martin Grumet; Gregg L Semenza; Hua Zhong; Jonathan W Simons; Jocelyn Holash; Stanley J Wiegand; George D Yancopoulos
Molecular events implicated in brain tumor angiogenesis and invasion.
Pediatric neurosurgery 2000;33(1):49-55.
2000: Jean-Paul Borg; Sylvie Marchetto; André Le Bivic; Vincent Ollendorff; Fanny Jaulin-Bastard; Hiroko Saito; E Fournier; José Adélaïde; Benjamin L Margolis; Daniel Birnbaum
ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor.
Nature cell biology 2000;2(7):407-14.
2000: T Doerks; P Bork; ES Kamberov; Olga Makarova; S Muecke; Benjamin L Margolis
L27, a novel heterodimerization domain in receptor targeting proteins Lin-2 and Lin-7.
Trends in biochemical sciences 2000;25(7):317-8.
2000: ES Kamberov; Olga Makarova; Michael H Roh; Albert Liu; David Karnak; Samuel W Straight; Benjamin L Margolis
Molecular cloning and characterization of Pals, proteins associated with mLin-7.
The Journal of biological chemistry 2000;275(15):11425-31.
2000: Samuel W Straight; David Karnak; Jean-Paul Borg; ES Kamberov; H Dare; Benjamin L Margolis; James B Wade
mLin-7 is localized to the basolateral surface of renal epithelia via its NH(2) terminus.
American journal of physiology. Renal physiology 2000;278(3):F464-75.
1999: D Meyer; Albert Liu; Benjamin L Margolis
Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons.
The Journal of biological chemistry 1999;274(49):35113-8.
1999: Benjamin L Margolis; Jean-Paul Borg; Samuel W Straight; D Meyer
The function of PTB domain proteins.
Kidney international 1999;56(4):1230-7.
1999: K A Alvi; H Pu; M Luche; A Rice; H App; G McMahon; H Dare; Benjamin L Margolis
Asterriquinones produced by Aspergillus candidus inhibit binding of the Grb-2 adapter to phosphorylated EGF receptor tyrosine kinase.
The Journal of antibiotics 1999;52(3):215-23.
1999: Jean-Paul Borg; M O Lõpez-Figueroa; M de Taddèo-Borg; Dallas Kroon; Raymond Scott Turner; Stanley J Watson Jr; Benjamin L Margolis
Molecular analysis of the X11-mLin-2/CASK complex in brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(4):1307-16.
1999: E Fournier; PA Blaikie; O Rosnet; Benjamin L Margolis; Daniel Birnbaum; Jean-Paul Borg
Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling.
Oncogene 1999;18(2):507-14.
1998: BHumsoo Kim; Hsinlin Thomas Cheng; Benjamin L Margolis; Eva L Feldman
Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.
The Journal of biological chemistry 1998;273(51):34543-50.
1998: M Trommsdorff; Jean-Paul Borg; Benjamin L Margolis; Joachim Herz
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.
The Journal of biological chemistry 1998;273(50):33556-60.
1998: Jean-Paul Borg; Samuel W Straight; S M Kaech; M de Taddéo-Borg; Dallas Kroon; David Karnak; Raymond Scott Turner; S K Kim; Benjamin L Margolis
Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting.
The Journal of biological chemistry 1998;273(48):31633-6.
1998: Sean F Leavey; Lois J Arend; H Dare; Gregory R Dressler; Josephine Briggs; Benjamin L Margolis
Expression of Grb7 growth factor receptor signaling protein in kidney development and in adult kidney.
The American journal of physiology 1998;275(5 Pt 2):F770-6.
1998: Jean-Paul Borg; Y k Yang; M De Taddéo-Borg; Benjamin L Margolis; Raymond Scott Turner
The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.
The Journal of biological chemistry 1998;273(24):14761-6.
1998: Lauren Yaich; J Ooi; M Park; Jean-Paul Borg; C Landry; Rolf Bodmer; Benjamin L Margolis
Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis.
The Journal of biological chemistry 1998;273(17):10381-8.
1998: V Yajnik; PA Blaikie; Benjamin L Margolis
Cloning and mutational analysis of the Shc-phosphotyrosine interaction/phosphotyrosine-binding domain.
Methods in molecular biology (Clifton, N.J.) 1998;84():223-35.
1998: Jean-Paul Borg; Benjamin L Margolis
Function of PTB domains.
Current topics in microbiology and immunology 1998;228():23-38.
1997: S Okada; AW Kao; Brian P Ceresa; PA Blaikie; Benjamin L Margolis; Jeffrey Pessin
The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.
The Journal of biological chemistry 1997;272(44):28042-9.
1997: Z Zhang; C H Lee; Valsan Mandiyan; Jean-Paul Borg; Benjamin L Margolis; Joseph Schlessinger; John Kuriyan
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
The EMBO journal 1997;16(20):6141-50.
1997: HY She; S Rockow; J Tang; R Nishimura; E Y Skolnik; Minggui Chen; Benjamin L Margolis; Wenhui Li
Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells.
Molecular biology of the cell 1997;8(9):1709-21.
1997: PA Blaikie; E Fournier; S M Dilworth; Daniel Birnbaum; Jean-Paul Borg; Benjamin L Margolis
The role of the Shc phosphotyrosine interaction/phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen-mediated cell transformation.
The Journal of biological chemistry 1997;272(33):20671-7.
1997: J Manser; Chanland Roonprapunt; Benjamin L Margolis
C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development.
Developmental biology 1997;184(1):150-64.
1996: Koutaro Yokote; Benjamin L Margolis; Carl-Henrik Heldin; Lena Claesson-Welsh
Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.
The Journal of biological chemistry 1996;271(48):30942-9.
1996: Jean-Paul Borg; J Ooi; Efrat Levy; Benjamin L Margolis
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Molecular and cellular biology 1996;16(11):6229-41.
1996: Benjamin L Margolis
The PI/PTB domain: a new protein interaction domain involved in growth factor receptor signaling.
The Journal of laboratory and clinical medicine 1996;128(3):235-41.
1996: Andrea Morrione; B Valentinis; Shengwen Li; J Y Ooi; Benjamin L Margolis; Renato Baserga
Grb10: A new substrate of the insulin-like growth factor I receptor.
Cancer research 1996;56(14):3165-7.
1996: Valsan Mandiyan; R O'Brien; M Zhou; Benjamin L Margolis; Mark A Lemmon; Julian M Sturtevant; Joseph Schlessinger
Thermodynamic studies of SHC phosphotyrosine interaction domain recognition of the NPXpY motif.
The Journal of biological chemistry 1996;271(9):4770-5.
1996: Steven J Isakoff; Y P Yu; YC Su; PA Blaikie; V Yajnik; E Rose; K M Weidner; M Sachs; Benjamin L Margolis; Edward Y Skolnik
Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivo.
The Journal of biological chemistry 1996;271(8):3959-62.
1996: V Yajnik; PA Blaikie; P Bork; Benjamin L Margolis
Identification of residues within the SHC phosphotyrosine binding/phosphotyrosine interaction domain crucial for phosphopeptide interaction.
The Journal of biological chemistry 1996;271(4):1813-6.
1995: A G Batzer; PA Blaikie; K Nelson; Joseph Schlessinger; Benjamin L Margolis
The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor.
Molecular and cellular biology 1995;15(8):4403-9.
1995: Ivan Dikic; A G Batzer; PA Blaikie; A Obermeier; A Ullrich; Joseph Schlessinger; Benjamin L Margolis
Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain.
The Journal of biological chemistry 1995;270(25):15125-9.
1995: Zhou Songyang; Benjamin L Margolis; M Chaudhuri; Steven E Shoelson; Lewis C Cantley
The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif.
The Journal of biological chemistry 1995;270(25):14863-6.
1995: J Ooi; V Yajnik; D Immanuel; M Gordon; John Moskow; Arthur Buchberg; Benjamin L Margolis
The cloning of Grb10 reveals a new family of SH2 domain proteins.
Oncogene 1995;10(8):1621-30.
1995: P Bork; Benjamin L Margolis
A phosphotyrosine interaction domain.
Cell 1995;80(5):693-4.
1995: Benjamin L Margolis; E Y Skolnik; J Schlessinger
Use of tyrosine-phosphorylated proteins to screen bacterial expression libraries for SH2 domains.
Methods in enzymology 1995;255():360-9.
1994: PA Blaikie; D Immanuel; J Wu; N Li; V Yajnik; Benjamin L Margolis
A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.
The Journal of biological chemistry 1994;269(51):32031-4.
1994: N Li; Joseph Schlessinger; Benjamin L Margolis
Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.
Oncogene 1994;9(12):3457-65.
1994: Benjamin L Margolis; Edward Y Skolnik
Activation of Ras by receptor tyrosine kinases.
Journal of the American Society of Nephrology : JASN 1994;5(6):1288-99.
1994: C H Lee; D Kominos; S Jacques; Benjamin L Margolis; J Schlessinger; S E Shoelson; John Kuriyan
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure (London, England : 1993) 1994;2(5):423-38.
1994: D Stein; J Wu; S A Fuqua; Chanland Roonprapunt; V Yajnik; P D'Eustachio; John Moskow; Arthur Buchberg; C Kent Osborne; Benjamin L Margolis
The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer.
The EMBO journal 1994;13(6):1331-40.
1994: Benjamin L Margolis
The GRB family of SH2 domain proteins.
Progress in biophysics and molecular biology 1994;62(3):223-44.
1993: Edward Y Skolnik; A Batzer; N Li; C H Lee; E Lowenstein; Moosa Mohammadi; Benjamin L Margolis; Joseph Schlessinger
The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
Science (New York, N.Y.) 1993;260(5116):1953-5.
1993: N Li; A Batzer; R Daly; V Yajnik; Edward Y Skolnik; Pierre Chardin; Dafna Bar-Sagi; Benjamin L Margolis; Joseph Schlessinger
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
Nature 1993;363(6424):85-8.
1993: Jean Paul olivier; Thomas Raabe; Mark Henkemeyer; Barry J Dickson; Geraldine Mbamalu; Benjamin L Margolis; J Schlessinger; Ernst Hafen; Tony Pawson
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.
Cell 1993;73(1):179-91.
1993: Patrick J Hu; Benjamin L Margolis; Joseph Schlessinger
Vav: a potential link between tyrosine kinases and ras-like GTPases in hematopoietic cell signaling.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(3):179-83.
1992: Benjamin L Margolis; O Silvennoinen; F Comoglio; Chanland Roonprapunt; Edward Y Skolnik; A Ullrich; Joseph Schlessinger
High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8894-8.
1992: Jonathan M Backer; Martin G Myers Jr; Steven E Shoelson; D J Chin; Xiao Jian Sun; M Miralpeix; Patrick J Hu; Benjamin L Margolis; E Y Skolnik; J Schlessinger
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
The EMBO journal 1992;11(9):3469-79.
1992: E J Lowenstein; R J Daly; A G Batzer; W Li; Benjamin L Margolis; R Lammers; A Ullrich; Edward Y Skolnik; Dafna Bar-Sagi; Joseph Schlessinger
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Cell 1992;70(3):431-42.
1992: W Li; G G Deanin; Benjamin L Margolis; Joseph Schlessinger; J M Oliver
Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells.
Molecular and cellular biology 1992;12(7):3176-82.
1992: D Rotin; A M Honegger; Benjamin L Margolis; A Ullrich; Joseph Schlessinger
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.
The Journal of biological chemistry 1992;267(14):9678-83.
1992: Benjamin L Margolis; Patrick J Hu; S Katzav; W Li; J M Oliver; A Ullrich; A Weiss; Joseph Schlessinger
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs.
Nature 1992;356(6364):71-4.
1992: Patrick J Hu; Benjamin L Margolis; Edward Y Skolnik; R Lammers; A Ullrich; Joseph Schlessinger
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
Molecular and cellular biology 1992;12(3):981-90.
1992: D Rotin; Benjamin L Margolis; Moosa Mohammadi; R J Daly; G Daum; N Li; Edmond H Fischer; W H Burgess; A Ullrich; Joseph Schlessinger
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
The EMBO journal 1992;11(2):559-67.
1992: D C Renard; M M Bolton; S G Rhee; Benjamin L Margolis; A Zilberstein; J Schlessinger; Andrew P Thomas
Modified kinetics of platelet-derived growth factor-induced Ca2+ increases in NIH-3T3 cells overexpressing phospholipase C gamma 1.
The Biochemical journal 1992;281 ( Pt 3)():775-84.
1992: Benjamin L Margolis
Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(1):73-80.
1992: Joseph Schlessinger; Moosa Mohammadi; Benjamin L Margolis; A Ullrich
Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases.
Cold Spring Harbor symposia on quantitative biology 1992;57():67-74.
1991: W Li; N Hack; Benjamin L Margolis; A Ullrich; K Skorecki; Joseph Schlessinger
Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses.
Cell regulation 1991;2(8):641-9.
1991: Linda Cannizzaro; E Y Skolnik; Benjamin L Margolis; C M Croce; J Schlesinger; Kay Huebner
The human gene encoding phosphatidylinositol-3 kinase associated p85 alpha is at chromosome region 5q12-13.
Cancer research 1991;51(14):3818-20.
1991: N Hack; Benjamin L Margolis; J Schlessinger; K Skorecki
Interaction of epidermal growth factor with vasoactive hormones in the regulation of phospholipase A2.
Journal of basic and clinical physiology and pharmacology 1991;2(3):161-82.
1991: H K Kim; J W Kim; A Zilberstein; Benjamin L Margolis; J G Kim; J Schlessinger; Sue Goo Rhee
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.
Cell 1991;65(3):435-41.
1991: N Hack; Benjamin L Margolis; A Ullrich; J Schlessinger; K L Skorecki
Distinct structural specificities for functional coupling of the epidermal growth factor receptor to calcium-signalling versus phospholipase A2 responses.
The Biochemical journal 1991;275 ( Pt 3)():563-7.
1991: Edward Y Skolnik; Benjamin L Margolis; Moosa Mohammadi; E Lowenstein; R Fischer; A Drepps; A Ullrich; Joseph Schlessinger
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
Cell 1991;65(1):83-90.
1991: Susan H Hirsch; A C Gutierrez-Pickett; Benjamin L Margolis
Medication education for an elderly black and Hispanic population in the United States.
Hygie 1991;10(4):36-9.
1990: Benjamin L Margolis; N Li; A Koch; Moosa Mohammadi; D R Hurwitz; A Zilberstein; A Ullrich; T Pawson; Joseph Schlessinger
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
The EMBO journal 1990;9(13):4375-80.
1990: Benjamin L Margolis; Asher Zilberstein; C Franks; S Felder; S Kremer; A Ullrich; S G Rhee; K Skorecki; Joseph Schlessinger
Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis.
Science (New York, N.Y.) 1990;248(4955):607-10.
1990: H J Goldberg; M M Viegas; Benjamin L Margolis; J Schlessinger; K L Skorecki
The tyrosine kinase activity of the epidermal-growth-factor receptor is necessary for phospholipase A2 activation.
The Biochemical journal 1990;267(2):461-5.
1990: Benjamin L Margolis; F Bellot; A M Honegger; A Ullrich; Joseph Schlessinger; A Zilberstein
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.
Molecular and cellular biology 1990;10(2):435-41.
1990: Rachel B Hazan; Benjamin L Margolis; M Dombalagian; A Ullrich; Asher Zilberstein; Joseph Schlessinger
Identification of autophosphorylation sites of HER2/neu.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(1):3-7.
1989: J R Downing; Benjamin L Margolis; A Zilberstein; R A Ashmun; A Ullrich; Charles J Sherr; J Schlessinger
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.
The EMBO journal 1989;8(11):3345-50.
1989: Benjamin L Margolis; S G Rhee; S Felder; M Mervic; R Lyall; A Levitzki; A Ullrich; Asher Zilberstein; Joseph Schlessinger
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.
Cell 1989;57(7):1101-7.
1989: Benjamin L Margolis; I Lax; R Kris; M Dombalagian; A M Honegger; R Howk; D Givol; A Ullrich; Joseph Schlessinger
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.
The Journal of biological chemistry 1989;264(18):10667-71.
1989: S Kremer; Benjamin L Margolis; P Harper; K Skorecki
Cyclosporine induced alterations in vasopressin signalling in the glomerular mesangial cell.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(3):201-6.
1989: S Kremer; Benjamin L Margolis; K Skorecki
A novel calcium signalling response in the breast cancer cell line MDA-468.
Biochemical and biophysical research communications 1989;159(3):1290-6.
1988: Benjamin L Margolis; B J Holub; Dean A Troyer; K L Skorecki
Epidermal growth factor stimulates phospholipase A2 in vasopressin-treated rat glomerular mesangial cells.
The Biochemical journal 1988;256(2):469-74.
1988: Mitchell L Halperin; Benjamin L Margolis; L A Robinson; R M Halperin; M L West; R A Bear
The urine osmolal gap: a clue to estimate urine ammonium in "hybrid" types of metabolic acidosis.
Clinical and investigative medicine. Médecine clinique et experimentale 1988;11(3):198-202.
1988: Benjamin L Margolis; J V Bonventre; S G Kremer; J E Kudlow; K L Skorecki
Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells.
The Biochemical journal 1988;249(2):587-92.
1986: Benjamin L Margolis; M D Lifschitz
The Spitzer-Weinstein syndrome: one form of type IV renal tubular acidosis and its response to hydrochlorothiazide.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1986;7(3):241-4.
1986: Benjamin L Margolis; R A Bear
Role of cyclosporine in recurrent hemolytic uremic syndrome in a renal allograft recipient.
Clinical transplants 1986;():124.
1985: Benjamin L Margolis; M D Lifschitz
Ammonia production and amino acid metabolism by rat renal papillary epithelial cells in culture.
The Journal of biological chemistry 1985;260(1):501-7.
1984: Benjamin L Margolis; J H Stein
The renal circulation.
International anesthesiology clinics 1984;22(1):35-63.
1974: Benjamin L Margolis; W H Kroes; R P Quinn
Job stress: an unlisted occupational hazard.
Journal of occupational medicine. : official publication of the Industrial Medical Association 1974;16(10):659-61.
1973: Benjamin L Margolis
Stress is a work hazard, too.
IMS, Industrial medicine and surgery 1973;42(9):20-3.