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Martin Myers Jr

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TOP 3
Martin G Myers Jr
How Is the Hungry Brain like a Sieve?
Martin G Myers Jr; David P Olson
Central nervous system control of metabolism.
Joshua A Johnson; Martin G Myers Jr; Lekshmi Nair; Josh Skorupski; Sal Calo; Megan Greenwald-Yarnell; Heidi B IglayReger; Peter F Bodary
Testosterone interacts with the feedback mechanisms engaged by Tyr985 of the leptin receptor and diet-induced obesity.

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All Publications

2013: Martin G Myers Jr
How Is the Hungry Brain like a Sieve?
Cell metabolism 2013;17(4):467-8.
2012: Martin G Myers Jr; David P Olson
Central nervous system control of metabolism.
Nature 2012;491(7424):357-63.
2012: Joshua A Johnson; Martin G Myers Jr; Lekshmi Nair; Josh Skorupski; Sal Calo; Megan Greenwald-Yarnell; Heidi B IglayReger; Peter F Bodary
Testosterone interacts with the feedback mechanisms engaged by Tyr985 of the leptin receptor and diet-induced obesity.
The Journal of steroid biochemistry and molecular biology 2012;132(3-5):212-9.
2012: Peter Mancuso; Martin G Myers Jr; Edmund O'Brien; David M Aronoff; Deepti Goel; Jared Goldberg; Carlos H Serezani; Marc Peters-Golden
Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(2):867-75.
2012: Rebecca Leshan; Ian E Gonzalez; Megan Greenwald-Yarnell; Christa M Patterson; Martin G Myers Jr
Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance.
Nature medicine 2012;18(5):820-3.
2012: Martin G Myers Jr; Matthias H Tschöp; Carol Haft; Steven B Heymsfield; Barbara B Kahn; Maren R. Laughlin; Rudolph L Leibel; Jack A Yanovski
Challenges and opportunities of defining clinical leptin resistance.
Cell metabolism 2012;15(2):150-6.
2011: Gina M Leinninger; Jill B Becker; Laura A Cappellucci; Lyndsay Christensen; Miro Faouzi; Margaret E Gnegy; Young-Hwan Jo; Darren M Opland; Emmanuel N Pothos; Christopher J Rhodes; Audrey F Seasholtz; Robert C Thompson; Martin G Myers Jr
Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance.
Cell metabolism 2011;14(3):313-23.
2011: Aaron J Grossberg; Gina M Leinninger; Peter R Levasseur; Martin G Myers Jr; XinXia Zhu; Theodore P Braun; Daniel L Marks
Inflammation-induced lethargy is mediated by suppression of orexin neuron activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(31):11376-86.
2011: Gwendolyn W Louis; Megan Greenwald-Yarnell; Rebecca Phillips; Lique M Coolen; Michael N Lehman; Martin G Myers Jr
Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis.
Endocrinology 2011;152(6):2302-10.
2011: Martin G Myers Jr; Charles F Burant
PPAR-γ action: it's all in your head.
Nature medicine 2011;17(5):544-5.
2011: Christa M Patterson; Rebecca Leshan; Justin C Jones; Martin G Myers Jr
Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells.
Brain research 2011;1378():18-28.
2011: Peter Mancuso; Marc Peters-Golden; Deepti Goel; Jared Goldberg; Thomas G Brock; Megan Greenwald-Yarnell; Martin G Myers Jr
Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):1081-90.
2011: Erica L Scheller; Kurt D Hankenson; Gina M Leinninger; Martin G Myers Jr; Paul H Krebsbach
Ectopic expression of Col2.3 and Col3.6 promoters in the brain and association with leptin signaling.
Cells, tissues, organs 2011;194(2-4):268-73.
2011: Wei Luo; Peter F Bodary; Yuechun Shen; Kevin J Wickenheiser; Miina Ohman; Chiao Guo; Kristina L Bahrou; Martin G Myers Jr; Daniel T Eitzman
Leptin receptor-induced STAT3-independent signaling pathways are protective against atherosclerosis in a murine model of obesity and hyperlipidemia.
Atherosclerosis 2011;214(1):81-5.
2010: Barton Wicksteed; Marcela Brissova; Wenbo Yan; Darren M Opland; Jennifer L Plank; Rachel B Reinert; Lorna M Dickson; Natalia A Tamarina; Louis H Philipson; Alena Shostak; Ernesto Bernal-Mizrachi; Lynda Elghazi-Cras; Michael W Roe; Patricia A Labosky; Martin G Myers Jr; Maureen Gannon; Alvin C Powers; Peter J Dempsey
Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.
Diabetes 2010;59(12):3090-8.
2010: Martin G Myers Jr
Outstanding Scientific Achievement Award Lecture 2010: deconstructing leptin: from signals to circuits.
Diabetes 2010;59(11):2708-14.
2010: Martin G Myers Jr; Rudolph L Leibel; Randy J Seeley; Michael W Schwartz
Obesity and leptin resistance: distinguishing cause from effect.
Trends in endocrinology and metabolism: TEM 2010;21(11):643-51.
2010: Darren M Opland; Gina M Leinninger; Martin G Myers Jr
Modulation of the mesolimbic dopamine system by leptin.
Brain research 2010;1350():65-70.
2010: Gwendolyn W Louis; Gina M Leinninger; Christopher J Rhodes; Martin G Myers Jr
Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(34):11278-87.
2010: Stephanie R Thorn; Sarah L Giesy; Martin G Myers Jr; Yves R Boisclair
Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling.
Endocrinology 2010;151(8):3985-95.
2010: Maura L Perry; Gina M Leinninger; Rong Chen; Kathryn D Luderman; Hongyan Yang; Margaret E Gnegy; Martin G Myers Jr; Robert T Kennedy
Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats.
Journal of neurochemistry 2010;114(3):666-74.
2010: Garrett Heinrich; Sumona Ghosh; Anthony M Deangelis; Jill M Schroeder-Gloeckler; Payal R Patel; Tamara R Castaneda; Shane Jeffers; Abraham D Lee; Dae Young Jung; Zhiyou Zhang; Darren M Opland; Martin G Myers Jr; Jason K Kim; Sonia M Najjar
Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice.
Gastroenterology 2010;139(2):644-52, 652.e1.
2010: Lawrence S Argetsinger; Jeanne A Stuckey; Scott A Robertson; Rositsa I Koleva; Joel M Cline; Jarrod A Marto; Martin G Myers Jr; Christin Carter-Su
Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.
Molecular endocrinology (Baltimore, Md.) 2010;24(5):1062-76.
2010: Alison S Reed; Elizabeth K Unger; Louise E Olofsson; Merisa L Piper; Martin G Myers Jr; Allison W Xu
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.
Diabetes 2010;59(4):894-906.
2010: Scott Robertson; Ryoko Ishida-Takahashi; Isao Tawara; Jiang Hu; Christa M Patterson; Justin C Jones; Rohit N Kulkarni; Martin G Myers Jr
Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions.
Diabetes 2010;59(4):782-90.
2010: Huiyuan Zheng; Laurel M Patterson; Christopher J Rhodes; Gwendolyn W Louis; Karolina Skibicka; Harvey J Grill; Martin G Myers Jr; Hans-Rudolf Berthoud
A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;298(3):R720-8.
2010: Martin G Myers Jr; Richard B Simerly
The neuroendocrinology and neuroscience of energy balance.
Frontiers in neuroendocrinology 2010;31(1):1-3.
2009: Eneida C Villanueva; Heike Münzberg; Daniela Cota; Rebecca Leshan; Keely Kopp; Ryoko Ishida-Takahashi; Justin C Jones; Diane C Fingar; Randy J Seeley; Martin G Myers Jr
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status.
Endocrinology 2009;150(10):4541-51.
2009: Eiichi Hinoi; Nan Gao; Dae Young Jung; Vijay Yadav; Tatsuya Yoshizawa; Daisuke Kajimura; Martin G Myers Jr; Streamson Chua Jr.; Qin Wang; Jason K Kim; Klaus H Kaestner; Gerard Karsenty
An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion.
Annals of the New York Academy of Sciences 2009;1173 Suppl 1():E20-30.
2009: Gina M Leinninger; Young-Hwan Jo; Rebecca Leshan; Gwendolyn W Louis; Hongyan Yang; Jason G Barrera; Hilary Wilson; Darren M Opland; Miro A Faouzi; Yusong Gong; Justin C Jones; Christopher J Rhodes; Streamson Chua Jr.; Sabrina Diano; Tamas L Horvath; Randy J Seeley; Jill B Becker; Heike Münzberg; Martin G Myers Jr
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding.
Cell metabolism 2009;10(2):89-98.
2009: Scott A Robertson; Rositsa I Koleva; Lawrence S Argetsinger; Christin Carter-Su; Jarrod A Marto; Edward P Feener; Martin G Myers Jr
Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling.
Molecular and cellular biology 2009;29(12):3367-78.
2009: Elvira Isganaitis; Josep C Jimenez-Chillaron; Melissa Woo; Alice Chow; Jennifer DeCoste; Martha Vokes; Manway Liu; Simon Kasif; Ann Marie Zavacki; Rebecca Leshan; Martin G Myers Jr; Mary-Elizabeth Patti
Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice.
Diabetes 2009;58(5):1192-200.
2009: Hiroyuki Mori; Ken Inoki; Heike Münzberg; Darren Opland; Miro Faouzi; Eneida C Villanueva; Tsuneo Ikenoue; David Kwiatkowski; Ormond A MacDougald; Martin G Myers Jr; Kun-Liang Guan
Critical role for hypothalamic mTOR activity in energy balance.
Cell metabolism 2009;9(4):362-74.
2009: Isabelle Gerin; Gwendolyn W Louis; Xuan Zhang; Tyler C Prestwich; T Rajendra Kumar; Martin G Myers Jr; Ormond A MacDougald; Warren B Nothnick
Hyperphagia and obesity in female mice lacking tissue inhibitor of metalloproteinase-1.
Endocrinology 2009;150(4):1697-704.
2009: Rebecca Leshan; Gwendolyn W Louis; Young-Hwan Jo; Christopher J Rhodes; Heike Münzberg; Martin G Myers Jr
Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(10):3138-47.
2009: Melissa E Gove; Davina H Rhodes; Maria Pini; Jantine van Baal; Joseph A Sennello; Raja Fayad; Robert J Cabay; Martin G Myers Jr; Giamila Fantuzzi
Role of leptin receptor-induced STAT3 signaling in modulation of intestinal and hepatic inflammation in mice.
Journal of leukocyte biology 2009;85(3):491-6.
2009: Martin G Myers Jr
Cell biology. Moonlighting in mitochondria.
Science (New York, N.Y.) 2009;323(5915):723-4.
2009: Martin G Myers Jr; Heike Münzberg; Gina M Leinninger; Rebecca Leshan
The geometry of leptin action in the brain: more complicated than a simple ARC.
Cell metabolism 2009;9(2):117-23.
2009: Lale Ozcan; Ayse Seda Ergin; Allen Lu; Jason Chung; Sumit Sarkar; Duyu Nie; Martin G Myers Jr; Umut Ozcan
Endoplasmic reticulum stress plays a central role in development of leptin resistance.
Cell metabolism 2009;9(1):35-51.
2009: George Stratigopoulos; Charles A LeDuc; Naoki Matsuoka; Roee Gutman; Richard Rausch; Scott A Robertson; Martin G Myers Jr; Wendy Chung; Streamson Chua Jr.; Rudolph L Leibel
Functional consequences of the human leptin receptor (LEPR) Q223R transversion.
Obesity (Silver Spring, Md.) 2009;17(1):126-35.
2008: Eiichi Hinoi; Nan Gao; Dae Young Jung; Vijay Yadav; Tatsuya Yoshizawa; Martin G Myers Jr; Streamson Chua Jr.; Jason K Kim; Klaus kaestner; Gerard Karsenty
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity.
The Journal of cell biology 2008;183(7):1235-42.
2008: Yu Shi; Vijay Yadav; Nina Suda; X Sherry Liu; X Edward Guo; Martin G Myers Jr; Gerard Karsenty
Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(51):20529-33.
2008: Eneida C Villanueva; Martin G Myers Jr
Leptin receptor signaling and the regulation of mammalian physiology.
International journal of obesity (2005) 2008;32 Suppl 7():S8-12.
2008: Scott A Robertson; Gina M Leinninger; Martin G Myers Jr
Molecular and neural mediators of leptin action.
Physiology & behavior 2008;94(5):637-42.
2008: Martin G Myers Jr
Metabolic sensing and regulation by the hypothalamus.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E809.
2008: Esther van de Wall; Rebecca Leshan; Allison W Xu; Nina Balthasar; Roberto Coppari; Shun Mei Liu; Young-Hwan Jo; Robert George MacKenzie; David Allison; Nae J Dun; Joel K Elmquist; Bradford B Lowell; Gregory S Barsh; Carl de Luca; Martin G Myers Jr; Gary J Schwartz; Streamson Chua Jr.
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.
Endocrinology 2008;149(4):1773-85.
2008: Merisa L Piper; Elizabeth K Unger; Martin G Myers Jr; Allison W Xu
Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons.
Molecular endocrinology (Baltimore, Md.) 2008;22(3):751-9.
2008: Ji-Yeon Lee; Heike Muenzberg; Oksana Gavrilova; Jacquelyn A Reed; Darlene Berryman; Eneida C Villanueva; Gwendolyn W Louis; Gina M Leinninger; Stefano Bertuzzi; Randy J Seeley; Gertraud W Robinson; Martin G Myers Jr; Lothar Hennighausen
Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.
PloS one 2008;3(2):e1639.
2008: Gina M Leinninger; Martin G Myers Jr
LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action.
Acta physiologica (Oxford, England) 2008;192(1):49-59.
2008: Martin G Myers Jr; Michael Alexander cowley; Heike Münzberg
Mechanisms of leptin action and leptin resistance.
Annual review of physiology 2008;70():537-56.
2007: Yusong Gong; Ryoko Ishida-Takahashi; Eneida C Villanueva; Diane C Fingar; Heike Münzberg; Martin G Myers Jr
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms.
The Journal of biological chemistry 2007;282(42):31019-27.
2007: Ghada A Soliman; Ryoko Ishida-Takahashi; Yusong Gong; Justin C Jones; Rebecca Leshan; Thomas L Saunders; Diane C Fingar; Martin G Myers Jr
A simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cells.
Transgenic research 2007;16(5):665-70.
2007: Zhiqin Li; Yingjiang Zhou; Christin Carter-Su; Martin G Myers Jr; Liangyou Rui
SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2270-81.
2007: Gwendolyn W Louis; Martin G Myers Jr
The role of leptin in the regulation of neuroendocrine function and CNS development.
Reviews in endocrine & metabolic disorders 2007;8(2):85-94.
2007: Marie Björnholm; Heike Münzberg; Rebecca Leshan; Eneida C Villanueva; Sarah H Bates; Gwendolyn W Louis; Justin C Jones; Ryoko Ishida-Takahashi; Christian Bjørbaek; Martin G Myers Jr
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function.
The Journal of clinical investigation 2007;117(5):1354-60.
2007: Heike Münzberg; Erin E Jobst; Sarah H Bates; Justin Jones; Eneida C Villanueva; Rebecca Leshan; Marie Björnholm; Joel K Elmquist; Mark Sleeman; Michael Alexander cowley; Martin G Myers Jr
Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(1):69-74.
2007: Peter F Bodary; Yuechun Shen; Miina Ohman; Kristina L Bahrou; Fernando B Vargas; Sarah S Cudney; Kevin J Wickenheiser; Martin G Myers Jr; Daniel T Eitzman
Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(1):70-6.
2006: Karim C El Kasmi; Jeff Holst; Maryaline Coffre; Lisa A Mielke; Antoine de Pauw; Nouara Lhocine; Amber M Smith; Robert Rutschman; Deepak Kaushal; Yuhong Shen; Takashi Suda; Raymond P Donnelly; Martin G Myers Jr; Warren Alexander; Dario A A Vignali; Stephanie S Watowich; Matthias Ernst; Douglas J Hilton; Peter J Murray
General nature of the STAT3-activated anti-inflammatory response.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7880-8.
2006: Rebecca Leshan; Marie Björnholm; Heike Münzberg; Martin G Myers Jr
Leptin receptor signaling and action in the central nervous system.
Obesity (Silver Spring, Md.) 2006;14 Suppl 5():208S-212S.
2006: Christoph Buettner; Alessandro Pocai; Evan D Muse; Anne M Etgen; Martin G Myers Jr; Luciano Rossetti
Critical role of STAT3 in leptin's metabolic actions.
Cell metabolism 2006;4(1):49-60.
2006: Barbara B Kahn; Martin G Myers Jr
mTOR tells the brain that the body is hungry.
Nature medicine 2006;12(6):615-7.
2006: Ryoko Ishida-Takahashi; Felicia Rosario; Yusong Gong; Keely Kopp; Zlatina Stancheva; Xiaohong Chen; Edward P Feener; Martin G Myers Jr
Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling.
Molecular and cellular biology 2006;26(11):4063-73.
2006: Martin G Myers Jr
Role reversal: brain insulin and liver STAT3.
Cell metabolism 2006;3(4):231-2.
2006: Richard W Gelling; Gregory J Morton; Christopher D Morrison; Kevin D Niswender; Martin G Myers Jr; Christopher J Rhodes; Michael W Schwartz
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
Cell metabolism 2006;3(1):67-73.
2005: Martin G Myers Jr; Mary Elizabeth Patti; Rebecca Leshan
Hitting the target: leptin and perinatal nutrition in the predisposition to obesity.
Endocrinology 2005;146(10):4209-10.
2005: Heike Münzberg; Martin G Myers Jr
Molecular and anatomical determinants of central leptin resistance.
Nature neuroscience 2005;8(5):566-70.
2005: Sarah L Dunn; Marie Björnholm; Sarah H Bates; Zhibin Chen; Matthew Seifert; Martin G Myers Jr
Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.
Molecular endocrinology (Baltimore, Md.) 2005;19(4):925-38.
2005: Sarah H Bates; Rohit N Kulkarni; Matthew Seifert; Martin G Myers Jr
Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis.
Cell metabolism 2005;1(3):169-78.
2005: Heike Münzberg; Marie Björnholm; Sarah H Bates; Martin G Myers Jr
Leptin receptor action and mechanisms of leptin resistance.
Cellular and molecular life sciences : CMLS 2005;62(6):642-52.
2004: Sarah H Bates; Trevor A Dundon; Matthew Seifert; Michael Carlson; Eleftheria Maratos-Flier; Martin G Myers Jr
LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin.
Diabetes 2004;53(12):3067-73.
2004: Edward P Feener; Felicia Rosario; Sarah L Dunn; Zlatina Stancheva; Martin G Myers Jr
Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling.
Molecular and cellular biology 2004;24(11):4968-78.
2004: Martin G Myers Jr
Leptin receptor signaling and the regulation of mammalian physiology.
Recent progress in hormone research 2004;59():287-304.
2004: Sarah H Bates; Martin G Myers Jr
The role of leptin-->STAT3 signaling in neuroendocrine function: an integrative perspective.
Journal of molecular medicine (Berlin, Germany) 2004;82(1):12-20.
2003: Sarah H Bates; Martin G Myers Jr
The role of leptin receptor signaling in feeding and neuroendocrine function.
Trends in endocrinology and metabolism: TEM 2003;14(10):447-52.
2003: Melissa Kay Lingohr; Lorna M Dickson; Christian E Wrede; Isabelle Briaud; Jill F McCuaig; Martin G Myers Jr; Christopher J Rhodes
Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
Molecular and cellular endocrinology 2003;209(1-2):17-31.
2003: Gabriella Segal-Lieberman; Richard L Bradley; Efi Kokkotou; Michael Carlson; Daniel Trombly; Xiaomei Wang; Sarah Bates; Martin G Myers Jr; Jeffrey S Flier; Eleftheria Maratos-Flier
Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):10085-90.
2003: Melissa Kay Lingohr; Lorna M Dickson; Christian E Wrede; Jill F McCuaig; Martin G Myers Jr; Christopher J Rhodes
IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
Molecular and cellular endocrinology 2003;204(1-2):85-99.
2003: Gregory J Morton; Kevin D Niswender; Christopher J Rhodes; Martin G Myers Jr; James E Blevins; Denis Baskin; Michael W Schwartz
Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.
Endocrinology 2003;144(5):2016-24.
2003: Sarah H Bates; Walter H Stearns; Trevor A Dundon; Markus Schubert; Annette W K Tso; Yongping Wang; Alexander S Banks; Hugh J Lavery; Asma K Haq; Eleftheria Maratos-Flier; Benjamin G Neel; Michael W Schwartz; Martin G Myers Jr
STAT3 signalling is required for leptin regulation of energy balance but not reproduction.
Nature 2003;421(6925):856-9.
2003: Kevin D Niswender; Christopher D Morrison; Deborah J Clegg; Ryan Olson; Denis Baskin; Martin G Myers Jr; Randy J Seeley; Michael W Schwartz
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia.
Diabetes 2003;52(2):227-31.
2002: Carolyn Kloek; Asma K Haq; Sarah L Dunn; Hugh J Lavery; Alexander S Banks; Martin G Myers Jr
Regulation of Jak kinases by intracellular leptin receptor sequences.
The Journal of biological chemistry 2002;277(44):41547-55.
2001: Kevin D Niswender; Gregory J Morton; W H Stearns; Christopher J Rhodes; Martin G Myers Jr; Michael W Schwartz
Intracellular signalling. Key enzyme in leptin-induced anorexia.
Nature 2001;413(6858):794-5.
2001: Lorna M Dickson; Melissa Kay Lingohr; Jill F McCuaig; S R Hugl; L Snow; B B Kahn; Martin G Myers Jr; Christopher J Rhodes
Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
The Journal of biological chemistry 2001;276(24):21110-20.
2001: Christian Bjørbaek; R M Buchholz; SM Davis; Sarah H Bates; Dominique D Pierroz; H Gu; Benjamin G Neel; Martin G Myers Jr; Jeffrey S Flier
Divergent roles of SHP-2 in ERK activation by leptin receptors.
The Journal of biological chemistry 2001;276(7):4747-55.
2001: R Mendez; G Welsh; M Kleijn; Martin G Myers Jr; M F White; C G Proud; R E Rhoads
Regulation of protein synthesis by insulin through IRS-1.
Progress in molecular and subcellular biology 2001;26():49-93.
2001: S P Cousin; Sigrun R Hügl; Christian E Wrede; Hiroshi Kajio; Martin G Myers Jr; Christopher J Rhodes
Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
Endocrinology 2001;142(1):229-40.
2000: C Bjorbak; Hugh J Lavery; Sarah H Bates; R K Olson; SM Davis; Jeffrey S Flier; Martin G Myers Jr
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.
The Journal of biological chemistry 2000;275(51):40649-57.
2000: Deborah J Burks; Jaime Font de Mora; Markus Schubert; DJ Withers; Martin G Myers Jr; HH Towery; S L Altamuro; Carrie L Flint; Morris F White
IRS-2 pathways integrate female reproduction and energy homeostasis.
Nature 2000;407(6802):377-82.
2000: Kristina M Kriauciunas; Martin G Myers Jr; C Ronald Kahn
Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1.
Molecular and cellular biology 2000;20(18):6849-59.
2000: Alexander S Banks; SM Davis; Sarah H Bates; Martin G Myers Jr
Activation of downstream signals by the long form of the leptin receptor.
The Journal of biological chemistry 2000;275(19):14563-72.
2000: Anna Krook; Marie Björnholm; Dana Galuska; XJ Jiang; R Fahlman; Martin G Myers Jr; Harriet Wallberg-Henriksson; Juleen R Zierath
Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.
Diabetes 2000;49(2):284-92.
2000: T Uchida; Martin G Myers Jr; Morris F White
IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.
Molecular and cellular biology 2000;20(1):126-38.
1999: S P Cousin; Sigrun R Hügl; Martin G Myers Jr; M F White; A Reifel-Miller; Christopher J Rhodes
Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
The Biochemical journal 1999;344 Pt 3():649-58.
1999: Zhen Y Jiang; Q L Zhou; A Chatterjee; Edward P Feener; Martin G Myers Jr; M F White; George L King
Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells.
Diabetes 1999;48(5):1120-30.
1999: Diana M Pitterle; R T Sperling; Martin G Myers Jr; M F White; Perry Blackshear
Early biochemical events in insulin-stimulated fluid phase endocytosis.
The American journal of physiology 1999;276(1 Pt 1):E94-E105.
1998: Laurent Delahaye; Isabelle Mothe-Satney; Martin G Myers Jr; MF White; Emmanuel Van Obberghen
Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites.
Endocrinology 1998;139(12):4911-9.
1998: M Yamamoto; Yoshiyuki Toya; Carsten Schwencke; MP Lisanti; Martin G Myers Jr; Y Ishikawa
Caveolin is an activator of insulin receptor signaling.
The Journal of biological chemistry 1998;273(41):26962-8.
1998: Martin G Myers Jr; R Mendez; P Shi; J H Pierce; R Rhoads; Morris F White
The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling.
The Journal of biological chemistry 1998;273(41):26908-14.
1997: Deborah J Burks; S Pons; HH Towery; J Smith-Hall; Martin G Myers Jr; Lynne Yenush; Morris F White
Heterologous pleckstrin homology domains do not couple IRS-1 to the insulin receptor.
The Journal of biological chemistry 1997;272(44):27716-21.
1997: Xiao Jian Sun; S Pons; L M Wang; Y Zhang; Lynne Yenush; Deborah J Burks; Martin G Myers Jr; E Glasheen; N G Copeland; N A Jenkins; J H Pierce; Morris F White
The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.
Molecular endocrinology (Baltimore, Md.) 1997;11(2):251-62.
1996: Lynne Yenush; K J Makati; J Smith-Hall; O Ishibashi; Martin G Myers Jr; Morris F White
The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1.
The Journal of biological chemistry 1996;271(39):24300-6.
1996: Martin G Myers Jr; Y Zhang; G A Aldaz; T Grammer; E M Glasheen; Lynne Yenush; L M Wang; Xiao Jian Sun; John Blenis; J H Pierce; Morris F White
YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites.
Molecular and cellular biology 1996;16(8):4147-55.
1996: R Mèndez; Martin G Myers Jr; M F White; Robert E Rhoads
Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase.
Molecular and cellular biology 1996;16(6):2857-64.
1996: Xiao Jian Sun; S Pons; T Asano; Martin G Myers Jr; E Glasheen; Morris F White
The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation.
The Journal of biological chemistry 1996;271(18):10583-7.
1996: Lynne Yenush; R Fernandez; Martin G Myers Jr; T C Grammer; Xiao Jian Sun; John Blenis; J H Pierce; J Schlessinger; Morris F White
The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis.
Molecular and cellular biology 1996;16(5):2509-17.
1996: Martin G Myers Jr; Morris F White
Insulin signal transduction and the IRS proteins.
Annual review of pharmacology and toxicology 1996;36():615-58.
1995: Xiao Jian Sun; L M Wang; Y Zhang; Lynne Yenush; Martin G Myers Jr; E Glasheen; William Stratton Lane; J H Pierce; Morris F White
Role of IRS-2 in insulin and cytokine signalling.
Nature 1995;377(6545):173-7.
1995: Martin G Myers Jr; Bentley Cheatham; T L Fisher; B R Jachna; C Ronald Kahn; Jonathan M Backer; Morris F White
Common and distinct elements in insulin and PDGF signaling.
Annals of the New York Academy of Sciences 1995;766():369-87.
1995: S Pons; T Asano; E Glasheen; M Miralpeix; Y Zhang; T L Fisher; Martin G Myers Jr; Xiao Jian Sun; Morris F White
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase.
Molecular and cellular biology 1995;15(8):4453-65.
1995: Lawrence S Argetsinger; G W Hsu; Martin G Myers Jr; Nils Billestrup; M F White; Christin Carter-Su
Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1.
The Journal of biological chemistry 1995;270(24):14685-92.
1995: Martin G Myers Jr; T C Grammer; J Brooks; E M Glasheen; L M Wang; Xiao Jian Sun; John Blenis; J H Pierce; Morris F White
The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling.
The Journal of biological chemistry 1995;270(20):11715-8.
1994: Martin G Myers Jr; T C Grammer; L M Wang; Xiao Jian Sun; J H Pierce; John Blenis; Morris F White
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.
The Journal of biological chemistry 1994;269(46):28783-9.
1994: L M Chuang; S F Hausdorff; Martin G Myers Jr; Morris F White; Morris J Birnbaum; C Ronald Kahn
Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes.
The Journal of biological chemistry 1994;269(44):27645-9.
1994: Martin G Myers Jr; Xiao Jian Sun; Morris F White
The IRS-1 signaling system.
Trends in biochemical sciences 1994;19(7):289-93.
1994: Martin G Myers Jr; L M Wang; Xiao Jian Sun; Y Zhang; Lynne Yenush; J Schlessinger; J H Pierce; Morris F White
Role of IRS-1-GRB-2 complexes in insulin signaling.
Molecular and cellular biology 1994;14(6):3577-87.
1994: D J Van Horn; Martin G Myers Jr; Jonathan M Backer
Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.
The Journal of biological chemistry 1994;269(1):29-32.
1993: C H Lee; W Li; R Nishimura; M Zhou; A G Batzer; Martin G Myers Jr; M F White; Joseph Schlessinger; Edward Y Skolnik
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11713-7.
1993: Xiao Jian Sun; D L Crimmins; Martin G Myers Jr; M Miralpeix; Morris F White
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.
Molecular and cellular biology 1993;13(12):7418-28.
1993: L M Chuang; Martin G Myers Jr; Jonathan M Backer; Steven E Shoelson; Morris F White; M J Birnbaum; C Ronald Kahn
Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.
Molecular and cellular biology 1993;13(11):6653-60.
1993: Ling Mei Wang; Martin G Myers Jr; Xiao Jian Sun; Stuart A Aaronson; M White; JH Pierce
IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
Science (New York, N.Y.) 1993;261(5128):1591-4.
1993: Milenko J Tanasijevic; Martin G Myers Jr; R S Thoma; D L Crimmins; Morris F White; David B Sacks
Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.
The Journal of biological chemistry 1993;268(24):18157-66.
1993: L M Chuang; Martin G Myers Jr; G A Seidner; Morris J Birnbaum; Morris F White; C Ronald Kahn
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5172-5.
1993: Edward Y Skolnik; C H Lee; A Batzer; L M Vicentini; M Zhou; R Daly; Martin G Myers Jr; Jonathan M Backer; A Ullrich; M F White
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
The EMBO journal 1993;12(5):1929-36.
1993: Martin G Myers Jr; Morris F White
The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains.
Diabetes 1993;42(5):643-50.
1993: Ling Mei Wang; Achsah D Keegan; Weiqun Li; G E Lienhard; S Pacini; J Silvio Gutkind; Martin G Myers Jr; Xiao Jian Sun; Morris F White; Stuart A Aaronson
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4032-6.
1993: Jonathan M Backer; Martin G Myers Jr; Xiao Jian Sun; D J Chin; Steven E Shoelson; M Miralpeix; Morris F White
Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells.
The Journal of biological chemistry 1993;268(11):8204-12.
1993: Martin G Myers Jr; Xiao Jian Sun; Bentley Cheatham; B R Jachna; E M Glasheen; Jonathan M Backer; Morris F White
IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.
Endocrinology 1993;132(4):1421-30.
1992: Xiao Jian Sun; M Miralpeix; Martin G Myers Jr; E M Glasheen; Jonathan M Backer; C Ronald Kahn; Morris F White
Expression and function of IRS-1 in insulin signal transmission.
The Journal of biological chemistry 1992;267(31):22662-72.
1992: Martin G Myers Jr; Jonathan M Backer; Xiao Jian Sun; Steven E Shoelson; Patrick J Hu; J Schlessinger; M Yoakim; Brian Schaffhausen; Morris F White
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10350-4.
1992: M Miralpeix; Xiao Jian Sun; Jonathan M Backer; Martin G Myers Jr; E Araki; Morris F White
Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells.
Biochemistry 1992;31(37):9031-9.
1992: Jonathan M Backer; Martin G Myers Jr; Steven E Shoelson; D J Chin; Xiao Jian Sun; M Miralpeix; Patrick J Hu; Benjamin L Margolis; E Y Skolnik; J Schlessinger
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
The EMBO journal 1992;11(9):3469-79.
1992: Jonathan M Backer; G G Schroeder; C Ronald Kahn; Martin G Myers Jr; P A Wilden; D A Cahill; Morris F White
Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
The Journal of biological chemistry 1992;267(2):1367-74.
1991: Martin G Myers Jr; Jonathan M Backer; K Siddle; Morris F White
The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus.
The Journal of biological chemistry 1991;266(16):10616-23.
1979: Martin G Myers Jr; H F Hope-Gill
Effect of d- and dl-propranolol on glucose-stimulated insulin release.
Clinical pharmacology and therapeutics 1979;25(3):303-8.