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Clyde Smith

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Paul G Young; Clyde Smith; Peter Metcalf; Edward N Baker
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP.
K Linke; P D Mace; Clyde Smith; David L Vaux; J Silke; Catherine L Day
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans.
Laura J Byrnes; Adriana Badarau; Sergei B Vakulenko; Clyde Smith
Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2''-phosphotransferase-Ic [APH(2'')-Ic] from Enterococcus gallinarum.

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All Publications

2008: Paul G Young; Clyde Smith; Peter Metcalf; Edward N Baker
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP.
Acta crystallographica. Section D, Biological crystallography 2008;D64(Pt 7):745-53.
2008: K Linke; P D Mace; Clyde Smith; David L Vaux; J Silke; Catherine L Day
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans.
Cell death and differentiation 2008;15(5):841-8.
2008: Laura J Byrnes; Adriana Badarau; Sergei B Vakulenko; Clyde Smith
Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2''-phosphotransferase-Ic [APH(2'')-Ic] from Enterococcus gallinarum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 2):126-9.
2007: Clyde Smith; Marisa Caccamo; Katherine A Kantardjieff; Sergei B Vakulenko
Structure of GES-1 at atomic resolution: insights into the evolution of carbapenamase activity in the class A extended-spectrum beta-lactamases.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 9):982-92.
2007: Luciana Hannibal; Clyde Smith; Donald W Jacobsen; Nicola E Brasch
Nitroxylcob(III)alamin: synthesis and X-ray structural characterization.
Angewandte Chemie (International ed. in English) 2007;46(27):5140-3.
2006: taru deva; Edward N Baker; Christopher J Squire; Clyde Smith
Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 12):1466-74.
2006: Edward Suarez-Moreira; Luciana Hannibal; Clyde Smith; Roberto A Chavez; Donald W Jacobsen; Nicola E Brasch
A simple, convenient method to synthesize cobalamins: synthesis of homocysteinylcobalamin, N-acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, sulfitocobalamin and nitrocobalamin.
Dalton transactions (Cambridge, England : 2003) 2006;(44):5269-77.
2006: Jackson Colin; Paul D Carr; Hye-Kyung Kim; Jian-Wei Liu; Paul Herrald; Natasa Mitić; Gerhard Schenk; Clyde Smith; David L Ollis
Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site.
The Biochemical journal 2006;397(3):501-8.
2006: P G Young; Clyde Smith; X Sun; Edward N Baker; Peter Metcalf
Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosisfolylpolyglutamate synthase (MtbFPGS).
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 6):579-82.
2006: Clyde Smith; Jennifer A Cross; Andrew L Bognar; Xiaolin Sun
Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 5):548-58.
2005: Graeme L Card; Neil A Peterson; Clyde Smith; Bernhard Rupp; Brian M Schick; Edward N Baker
The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis.
The Journal of biological chemistry 2005;280(14):13978-86.
2005: Rupa Walanj; Paul Young; Heather M Baker; Edward N Baker; Peter Metcalf; Joseph W Chow; Stephen A Lerner; Sergei B Vakulenko; Clyde Smith
Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2''-phosphotransferase-Ib [APH(2'')-Ib].
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 4):410-3.
2003: taru deva; KellyAnn D Pryor; Barbara Leiting; Edward N Baker; Clyde Smith
Purification, crystallization and preliminary X-ray analysis of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 8):1510-3.
2003: Didier Nurizzo; Steven C Shewry; Michael H Perlin; Scott A Brown; Jaydev N Dholakia; Roy L Fuchs; taru deva; Edward N Baker; Clyde Smith
The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance.
Journal of molecular biology 2003;327(2):491-506.
2003: Esti Liani; Lilah Rothem; Marlene A Bunni; Clyde Smith; Gerrit Jansen; Yehuda G Assaraf
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
International journal of cancer. Journal international du cancer 2003;103(5):587-99.
2002: Clyde Smith; Edward N Baker
Aminoglycoside antibiotic resistance by enzymatic deactivation.
Current drug targets. Infectious disorders 2002;2(2):143-60.
2002: Yi Sheng; Jennifer A Cross; Yang Shen; Clyde Smith; Andrew L Bognar
Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding.
Archives of biochemistry and biophysics 2002;402(1):94-103.
2001: Xiaolin Sun; Jennifer A Cross; Andrew L Bognar; Edward N Baker; Clyde Smith
Folate-binding triggers the activation of folylpolyglutamate synthetase.
Journal of molecular biology 2001;310(5):1067-78.
2001: Mark J Banfield; M E Salvucci; Edward N Baker; Clyde Smith
Crystal structure of the NADP(H)-dependent ketose reductase from Bemisia argentifolii at 2.3 A resolution.
Journal of molecular biology 2001;306(2):239-50.
2000: Heather M Baker; C J Baker; Clyde Smith; Edward N Baker
Metal substitution in transferrins: specific binding of cerium(IV) revealed by the crystal structure of cerium-substituted human lactoferrin.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(6):692-8.
2000: Yi Sheng; Xiaolin Sun; Yang Shen; Andrew L Bognar; Edward N Baker; Clyde Smith
Structural and functional similarities in the ADP-forming amide bond ligase superfamily: implications for a substrate-induced conformational change in folylpolyglutamate synthetase.
Journal of molecular biology 2000;302(2):427-40.
2000: H S Toogood; Clyde Smith; E N Baker; Roy M Daniel
Purification and characterization of Ak.1 protease, a thermostable subtilisin with a disulphide bond in the substrate-binding cleft.
The Biochemical journal 2000;350 Pt 1():321-8.
2000: Ross T A MacGillivray; Maria C Bewley; Clyde Smith; Qing-Yu He; Anne Mason; Robert C Woodworth; Edward N Baker
Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release.
Biochemistry 2000;39(6):1211-6.
1999: Clyde Smith; H S Toogood; Heather M Baker; Roy M Daniel; Edward N Baker
Calcium-mediated thermostability in the subtilisin superfamily: the crystal structure of Bacillus Ak.1 protease at 1.8 A resolution.
Journal of molecular biology 1999;294(4):1027-40.
1998: X Sun; A L Bognar; Edward N Baker; Clyde Smith
Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6647-52.
1998: Ross T A MacGillivray; S A Moore; J Chen; Bryan F Anderson; H Baker; Y Luo; Maria C Bewley; Clyde Smith; Michael E P Murphy; Yili Wang; Anne Mason; Robert C Woodworth; Gary D Brayer; Edward N Baker
Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.
Biochemistry 1998;37(22):7919-28.
1996: Heather M Baker; Bryan F Anderson; Andrew M Brodie; M S Shongwe; Clyde Smith; Edward N Baker
Anion binding by transferrins: importance of second-shell effects revealed by the crystal structure of oxalate-substituted diferric lactoferrin.
Biochemistry 1996;35(28):9007-13.
1996: Clyde Smith; Ivan Rayment
X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution.
Biochemistry 1996;35(17):5404-17.
1996: Clyde Smith; Ivan Rayment
Active site comparisons highlight structural similarities between myosin and other P-loop proteins.
Biophysical journal 1996;70(4):1590-602.
1995: Clyde Smith; M L Pratchett; Edward N Baker
Crystallization and preliminary X-ray diffraction studies of arginase from a thermophilic organism Bacillus caldevelox.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):840-1.
1995: Clyde Smith; Ivan Rayment
X-ray structure of the magnesium(II)-pyrophosphate complex of the truncated head of Dictyostelium discoideum myosin to 2.7 A resolution.
Biochemistry 1995;34(28):8973-81.
1995: A J Fisher; Clyde Smith; James B Thoden; R Smith; K Sutoh; Hazel M Holden; Ivan Rayment
X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-.
Biochemistry 1995;34(28):8960-72.
1995: A J Fisher; Clyde Smith; James B Thoden; R Smith; K Sutoh; Hazel M Holden; Ivan Rayment
Structural studies of myosin:nucleotide complexes: a revised model for the molecular basis of muscle contraction.
Biophysical journal 1995;68(4 Suppl):19S-26S; discussion 27S-28S.
1994: Clyde Smith; Bryan F Anderson; Heather M Baker; Edward N Baker
Structure of copper- and oxalate-substituted human lactoferrin at 2.0 A resolution.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 3):302-16.
1994: Andrew M Brodie; Eric W Ainscough; Edward N Baker; Heather M Baker; M S Shongwe; Clyde Smith
Synergism and substitution in the lactoferrins.
Advances in experimental medicine and biology 1994;357():33-44.
1994: Clyde Smith; Heather M Baker; M S Shongwe; Bryan F Anderson; Edward N Baker
Crystallographic studies on metal and anion substituted human lactoferrin.
Advances in experimental medicine and biology 1994;357():265-9.
1994: Edward N Baker; Bryan F Anderson; Heather M Baker; C L Day; M Haridas; G E Norris; S V Rumball; Clyde Smith; D H Thomas
Three-dimensional structure of lactoferrin in various functional states.
Advances in experimental medicine and biology 1994;357():1-12.
1992: Clyde Smith; Bryan F Anderson; Heather M Baker; Edward N Baker
Metal substitution in transferrins: the crystal structure of human copper-lactoferrin at 2.1-A resolution.
Biochemistry 1992;31(18):4527-33.
1992: M S Shongwe; Clyde Smith; Eric W Ainscough; Heather M Baker; Andrew M Brodie; Edward N Baker
Anion binding by human lactoferrin: results from crystallographic and physicochemical studies.
Biochemistry 1992;31(18):4451-8.
1992: Edward N Baker; Heather M Baker; Clyde Smith; M R Stebbins; M Kahn; K E Hellström; I Hellström
Human melanotransferrin (p97) has only one functional iron-binding site.
FEBS letters 1992;298(2-3):215-8.
1991: Edward N Baker; Bryan F Anderson; Heather M Baker; M Haridas; Geoffrey B Jameson; G E Norris; S V Rumball; Clyde Smith
Structure, function and flexibility of human lactoferrin.
International journal of biological macromolecules 1991;13(3):122-9.
1991: Clyde Smith; Heather M Baker; Edward N Baker
Preliminary crystallographic studies of copper(II)- and oxalate-substituted human lactoferrin.
Journal of molecular biology 1991;219(2):155-9.