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David Lombard

Research Profile

Chemicals & Drugs

Living Beings

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Acetylation

Disorders

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Anatomy

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Publications

TOP 3
Nisha Narayan; Ilsa I Rovira; Michael N Sack; Junhui Sun; Guang Tong; Guanghui Wang; Renee Wong; Fredrick W Alt; Ronen Borenstein; Liu Cao; Hwei-Ling Cheng; Maria M Fergusson; Marjan Gucek; In Hye Lee; Jie Liu; David Lombard; Elizabeth Murphy; TOREN FINKEL
The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.
Carlos Sebastián; Paul G Shiels; Dafne M Silberman; Debra Toiber; Jessica Truelove; Ralph Weissleder; Lei Zhong; Bernadette M M Zwaans; Bradley E Bernstein; Claudia Cosentino; Joanne Edwards; Sofia Giacosa; Alon Goren; Joel K Greenson; Ernesto Guccione; Alexander R Guimaraes; Melissa Gymrek; David Lombard; Alasdair I MacDonald; Fraser Maxwell; Liane McGlynn; Oren Ram; Aviv Regev; Raul Mostoslavsky
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Nagalingam R Sundaresan; Prabhakaran Vasudevan; Lei Zhong; John M Cunningham; Chu-Xia Deng; Madhu Gupta; Valluvan Jeevanandam; Gene Kim; David Lombard; Raul Mostoslavsky; Vishwas Parekh; Vinodkumar B Pillai; P V Ravindra; Sadhana Samant; Mahesh P Gupta
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.

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All Publications

2012: Nisha Narayan; Ilsa I Rovira; Michael N Sack; Junhui Sun; Guang Tong; Guanghui Wang; Renee Wong; Fredrick W Alt; Ronen Borenstein; Liu Cao; Hwei-Ling Cheng; Maria M Fergusson; Marjan Gucek; In Hye Lee; Jie Liu; David Lombard; Elizabeth Murphy; TOREN FINKEL
The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.
Nature 2012;492(7428):199-204.
2012: Carlos Sebastián; Paul G Shiels; Dafne M Silberman; Debra Toiber; Jessica Truelove; Ralph Weissleder; Lei Zhong; Bernadette M M Zwaans; Bradley E Bernstein; Claudia Cosentino; Joanne Edwards; Sofia Giacosa; Alon Goren; Joel K Greenson; Ernesto Guccione; Alexander R Guimaraes; Melissa Gymrek; David Lombard; Alasdair I MacDonald; Fraser Maxwell; Liane McGlynn; Oren Ram; Aviv Regev; Raul Mostoslavsky
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Cell 2012;151(6):1185-99.
2012: Nagalingam R Sundaresan; Prabhakaran Vasudevan; Lei Zhong; John M Cunningham; Chu-Xia Deng; Madhu Gupta; Valluvan Jeevanandam; Gene Kim; David Lombard; Raul Mostoslavsky; Vishwas Parekh; Vinodkumar B Pillai; P V Ravindra; Sadhana Samant; Mahesh P Gupta
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Nature medicine 2012;18(11):1643-50.
2012: Wei-Chung Chiang; Mark Eckersdorff; Steven P Gygi; David Lombard; Travis Mazer; Daniel X Tishkoff; Joshua Wilson-Grady; Bo Yang; Xiaokun Yu; Ao-Lin Hsu
C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.
PLoS genetics 2012;8(9):e1002948.
2012: David Lombard; Richard A Miller
Ageing: Sorting out the sirtuins.
Nature 2012;483(7388):166-7.
2011: Chao Peng; Minjia Tan; Daniel Tishkoff; Eric Verdin; Zhongyu Xie; Ke Yang; Yang Ye; Yi Zhang; Yue Chen; Zhongyi Cheng; Junbiao Dai; Tong-Chuan He; Wendy He; Linh Ho; David Lombard; Zhike Lu; Hao Luo; Bernadette M M Zwaans; Yingming Zhao
The first identification of lysine malonylation substrates and its regulatory enzyme.
Molecular & cellular proteomics : MCP 2011;10(12):M111.012658.
2011: David Lombard; Scott D Pletcher; Carles Cantó; Johan Auwerx
Ageing: longevity hits a roadblock.
Nature 2011;477(7365):410-1.
2011: Enxuan Jing; Jeremie Boucher; Brice Emanuelli; Matthew David Hirschey; Kevin Y Lee; David Lombard; Eric M Verdin; C Ronald Kahn
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(35):14608-13.
2011: Zhongping Lu; Lance R Pohl; Angel M Aponte; Mohammed Bourdi; Yong Chen; Marjan Gucek; Jian H Li; David Lombard; Michael N Sack
SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.
EMBO reports 2011;12(8):840-6.
2011: David Lombard; Daniel X Tishkoff; Jianjun Bao
Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.
Handbook of experimental pharmacology 2011;206():163-88.
2010: Bjoern Schwer; Bjoern Schumacher; David Lombard; Cuiying Xiao; Martin V Kurtev; Jun Gao; Jennifer I Schneider; Hua Chai; Roderick T Bronson; Li-Huei Tsai; Chu-Xia Deng; Frederick W Alt
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21790-4.
2010: Tadahiro Shimazu; Matthew David Hirschey; Lan Hua; Kristin E Dittenhafer-Reed; Bjoern Schwer; David Lombard; Yu Li; Jakob Bunkenborg; Frederick W Alt; John M Denu; Matthew P Jacobson; Eric Verdin
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
Cell metabolism 2010;12(6):654-61.
2010: Matthew David Hirschey; Tadahiro Shimazu; Eric Goetzman; Enxuan Jing; Bjoern Schwer; David Lombard; Carrie A Grueter; Charles Harris; Sudha Biddinger; Olga R Ilkayeva; Robert D Stevens; Yu Li; Asish K Saha; Neil B Ruderman; James R Bain; Christopher B Newgard; Robert V Farese; Frederick W Alt; C Ronald Kahn; Eric Verdin
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Nature 2010;464(7285):121-5.
2009: Bjoern Schwer; Mark Eckersdorff; Yu Li; Jeffrey C Silva; Damian Fermin; Martin V Kurtev; Cosmas Giallourakis; Michael J Comb; Frederick W Alt; David Lombard
Calorie restriction alters mitochondrial protein acetylation.
Aging cell 2009;8(5):604-6.
2009: Bo Yang; Bernadette M M Zwaans; Mark Eckersdorff; David Lombard
The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability.
Cell cycle (Georgetown, Tex.) 2009;8(16):2662-3.
2009: David Lombard
Sirtuins at the breaking point: SIRT6 in DNA repair.
Aging 2009;1(1):12-6.
2008: In Hye Lee; Liu Cao; Raul Mostoslavsky; David Lombard; Jie Liu; Nicholas E Bruns; Maria Tsokos; Frederick W Alt; TOREN FINKEL
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3374-9.
2008: Yu Zhang; Sohee Kwon; Teppei Yamaguchi; fabien cubizolles; Sophie Rousseaux; Michaela Kneissel; Chun Cao; Na Li; Hwei-Ling Cheng; Katrin Chua; David Lombard; Adam Mizeracki; Gabriele Matthias; Frederick W Alt; Saadi Khochbin; Patrick Matthias
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.
Molecular and cellular biology 2008;28(5):1688-701.
2008: David Lombard; Bjoern Schwer; Frederick W Alt; Raul Mostoslavsky
SIRT6 in DNA repair, metabolism and ageing.
Journal of internal medicine 2008;263(2):128-41.
2007: David Lombard; Frederick W Alt; Hwei-Ling Cheng; Jakob Bunkenborg; Ryan S Streeper; Raul Mostoslavsky; Jennifer Kim; George D Yancopoulos; David M Valenzuela; Andrew Murphy; Yinhua Yang; Yaohui Chen; Matthew David Hirschey; Roderick T Bronson; Marcia Haigis; Leonard Guarente; Robert V Farese; Sherman Weissman; Eric Verdin; Bjoern Schwer
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Molecular and cellular biology 2007;27(24):8807-14.
2006: Raul Mostoslavsky; Katrin F Chua; David Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli P Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
Cell 2006;124(2):315-29.
2006: Sonia Franco; Monica Gostissa; Shan Zha; David Lombard; Michael M Murphy; Ali A Zarrin; Catherine Yan; Suprawee Tepsuporn; Julio Cesar Morales; Melissa M Adams; Zhenkun Lou; Craig H Bassing; John P Manis; Junjie Chen; Phillip B Carpenter; Frederick W Alt
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.
Molecular cell 2006;21(2):201-14.
2005: Katrin F Chua; Raul Mostoslavsky; David Lombard; Wendy W Pang; Shin'ichi Saito; Sonia Franco; Dhruv Kaushal; Hwei-Ling Cheng; Miriam R Fischer; Nicole Stokes; Michael M Murphy; Ettore Appella; Frederick W Alt
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.
Cell metabolism 2005;2(1):67-76.
2005: David Lombard; Katrin F Chua; Raul Mostoslavsky; Sonia Franco; Monica Gostissa; Frederick W Alt
DNA repair, genome stability, and aging.
Cell 2005;120(4):497-512.
2004: Xiaobing Du; Johnny Shen; Nishan Kugan; Emma E Furth; David Lombard; Catherine Cheung; Sally Pak; Guangbin Luo; Robert J Pignolo; Ronald A DePinho; Leonard Guarente; F Brad Johnson
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.
Molecular and cellular biology 2004;24(19):8437-46.
2004: Sandy Chang; Asha S Multani; Noelia G Cabrera; Maria L Naylor; Purnima Laud; David Lombard; Sen Pathak; Leonard Guarente; Ronald A DePinho
Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
Nature genetics 2004;36(8):877-82.
2003: Sean Rooney; Frederick W Alt; David Lombard; Scott Whitlow; Mark Eckersdorff; James Fleming; Sebastian D Fugmann; David O Ferguson; David G Schatz; JoAnn Sekiguchi
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.
The Journal of experimental medicine 2003;197(5):553-65.
2002: Sean Rooney; JoAnn Sekiguchi; Chengming Zhu; Hwei-Ling Cheng; John P Manis; Scott Whitlow; Jeff DeVido; Dan Foy; Jayanta Chaudhuri; David Lombard; Frederick W Alt
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.
Molecular cell 2002;10(6):1379-90.
2002: Paula Stein; Petr Svoboda; Deborah J Stumpo; Perry Blackshear; David Lombard; Brad Johnson; Richard M Schultz
Analysis of the role of RecQ helicases in RNAi in mammals.
Biochemical and biophysical research communications 2002;291(5):1119-22.
2000: David Lombard; Leonard Guarente
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres.
Cancer research 2000;60(9):2331-4.
2000: David Lombard; Caroline Beard; Brad Johnson; Robert Marciniak; Jessica Dausman; R Bronson; J E Buhlmann; R Lipman; R Curry; A Sharpe; Rudolf Jaenisch; Leonard Guarente
Mutations in the WRN gene in mice accelerate mortality in a p53-null background.
Molecular and cellular biology 2000;20(9):3286-91.
2000: F Brad Johnson; David Lombard; N F Neff; M A Mastrangelo; W Dewolf; Nathan Ellis; Robert Marciniak; Y Yin; Rudolf Jaenisch; Leonard Guarente
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.
Cancer research 2000;60(5):1162-7.
1998: Robert Marciniak; David Lombard; F Brad Johnson; Leonard Guarente
Nucleolar localization of the Werner syndrome protein in human cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6887-92.
1996: David Lombard; L Guarente
Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging.
Trends in genetics : TIG 1996;12(8):283-6.
1993: Gordon J Freeman; F Borriello; Richard J Hodes; H Reiser; Karen S Hathcock; G Laszlo; A J McKnight; J Kim; L Du; David Lombard
Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.
Science (New York, N.Y.) 1993;262(5135):907-9.
1993: T Lindsten; Kelvin P Lee; E S Harris; B Petryniak; Nancy Craighead; P J Reynolds; David Lombard; Gordon J Freeman; Lee M Nadler; GS Gray
Characterization of CTLA-4 structure and expression on human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(7):3489-99.
1992: Gordon J Freeman; David Lombard; C D Gimmi; S A Brod; K Lee; J C Laning; David A Hafler; M E Dorf; GS Gray; H Reiser
CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):3795-801.
1991: Gordon J Freeman; GS Gray; C D Gimmi; David Lombard; L J Zhou; M White; Joyce Diane Fingeroth; John G Gribben; Lee M Nadler
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.
The Journal of experimental medicine 1991;174(3):625-31.