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Johannes Buchner

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Physiology

Protein Folding

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TOP 3
Alina Röhl; Julia Rohrberg; Johannes Buchner
The chaperone Hsp90: changing partners for demanding clients.
Jing Li; Jochen Reinstein; Klaus Richter; Johannes Buchner
Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle.
Moritz Marcinowski; Mathias Rosam; Christine Seitz; Johannes Elferich; Matthias J Feige; Iris Antes; Christian F W Becker; Julia Behnke; Claudia Bello; Johannes Buchner
Conformational selection in substrate recognition by Hsp70 chaperones.

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All Publications

2013: Alina Röhl; Julia Rohrberg; Johannes Buchner
The chaperone Hsp90: changing partners for demanding clients.
Trends in biochemical sciences 2013;38(5):253-62.
2013: Jing Li; Jochen Reinstein; Klaus Richter; Johannes Buchner
Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle.
Nature structural & molecular biology 2013;20(3):326-31.
2013: Moritz Marcinowski; Mathias Rosam; Christine Seitz; Johannes Elferich; Matthias J Feige; Iris Antes; Christian F W Becker; Julia Behnke; Claudia Bello; Johannes Buchner
Conformational selection in substrate recognition by Hsp70 chaperones.
Journal of molecular biology 2013;425(3):466-74.
2013: Marco Retzlaff; Julia Rohrberg; Alexander Bepperling; Horst Kessler; Natascha Jennifer Küpper; Stephan Lagleder; Florian Manzenrieder; Jirka Peschek; Johannes Buchner
The regulatory domain stabilizes the p53 tetramer by intersubunit contacts with the DNA binding domain.
Journal of molecular biology 2013;425(1):144-55.
2013: Fatiha Kateb; Helene Perrin; Roberta Spadaccini; Konstantinos Tripsianes; Peijian Zou; Stéphane Ansieau; Matthew Bottomley; Johannes Buchner; Titus M Franzmann; Michael Sattler
Structural and functional analysis of the DEAF-1 and BS69 MYND domains.
PloS one 2013;8(1):e54715.
2012: Alexander Bepperling; Nathalie Braun; Ferdinand Alte; Michael Groll; Martin Haslbeck; Thomas Kriehuber; Sevil Weinkauf; Johannes Buchner
Alternative bacterial two-component small heat shock protein systems.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):20407-12.
2012: Joanna Soroka; Johannes Buchner
Mechanistic aspects of the Hsp90 phosphoregulation.
Cell cycle (Georgetown, Tex.) 2012;11(10):1870-1.
2012: Thiemo B Schreiber; Joanna Soroka; Sebastian K Wandinger; Johannes Buchner; Nina Mäusbacher; Henrik Daub
Global analysis of phosphoproteome regulation by the Ser/Thr phosphatase Ppt1 in Saccharomyces cerevisiae.
Journal of proteome research 2012;11(4):2397-408.
2012: Andreas B Schmid; Sebastian K Wandinger; Marc B Cox; Oliver Demmer; Melissa Ann Gräwert; Michael Groll; Franz Hagn; Horst Kessler; Stephan Lagleder; Klaus Richter; Alina Röhl; Johannes Buchner
The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
The EMBO journal 2012;31(6):1506-17.
2012: Joanna Soroka; Sebastian K Wandinger; Henrik Daub; Nina Mäusbacher; Klaus Richter; Thiemo Schreiber; Johannes Buchner
Conformational switching of the molecular chaperone Hsp90 via regulated phosphorylation.
Molecular cell 2012;45(4):517-28.
2011: Klaus Richter; Johannes Buchner
Closing in on the Hsp90 chaperone-client relationship.
Structure (London, England : 1993) 2011;19(4):445-6.
2011: Moritz Marcinowski; Matthias Höller; Matthias J Feige; Danae Baerend; Don C Lamb; Johannes Buchner
Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions.
Nature structural & molecular biology 2011;18(2):150-8.
2011: Jing Li; Klaus Richter; Johannes Buchner
Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle.
Nature structural & molecular biology 2011;18(1):61-6.
2010: Bernd Anselment; Danae Baerend; Elisabeth Mey; Johannes Buchner; Dirk Weuster-Botz; Martin Haslbeck
Experimental optimization of protein refolding with a genetic algorithm.
Protein science : a publication of the Protein Society 2010;19(11):2085-95.
2010: Klaus Richter; Martin Haslbeck; Johannes Buchner
The heat shock response: life on the verge of death.
Molecular cell 2010;40(2):253-66.
2010: Thomas Kriehuber; Thomas Rattei; Thomas Weinmaier; Alexander Bepperling; Martin Haslbeck; Johannes Buchner
Independent evolution of the core domain and its flanking sequences in small heat shock proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):3633-42.
2010: C Ratzke; M Mickler; B Hellenkamp; Johannes Buchner; Thorsten Hugel
Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(37):16101-6.
2010: Sylvia Welker; Birgit Rudolph; Elke Frenzel; Franz Hagn; Gerhard Liebisch; Gerd Schmitz; Johannes Scheuring; Andreas Kerth; Alfred Blume; Sevil Weinkauf; Martin Haslbeck; Horst Kessler; Johannes Buchner
Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function.
Molecular cell 2010;39(4):507-20.
2010: Morten Bertz; Jin Chen; Matthias J Feige; Titus M Franzmann; Johannes Buchner; Matthias Rief
Structural and mechanical hierarchies in the alpha-crystallin domain dimer of the hyperthermophilic small heat shock protein Hsp16.5.
Journal of molecular biology 2010;400(5):1046-56.
2010: Matthias Johannes Feige; Emma Rhiannon Simpson; Eva Maria Herold; Alexander Bepperling; Klaus Heger; Johannes Buchner
Dissecting the alternatively folded state of the antibody Fab fragment.
Journal of molecular biology 2010;399(5):719-30.
2010: Birgit Rudolph; Katharina M Gebendorfer; Johannes Buchner; Jeannette Winter
Evolution of Escherichia coli for growth at high temperatures.
The Journal of biological chemistry 2010;285(25):19029-34.
2010: Johannes Buchner
Bacterial Hsp90--desperately seeking clients.
Molecular microbiology 2010;76(3):540-4.
2010: Jin Chen; Matthias J Feige; Titus M Franzmann; Alexander Bepperling; Johannes Buchner
Regions outside the alpha-crystallin domain of the small heat shock protein Hsp26 are required for its dimerization.
Journal of molecular biology 2010;398(1):122-31.
2010: Matthias J Feige; Linda M Hendershot; Johannes Buchner
How antibodies fold.
Trends in biochemical sciences 2010;35(4):189-98.
2010: Marco Retzlaff; Franz Hagn; Lars Mitschke; Martin Hessling; Frederik Gugel; Horst Kessler; Klaus Richter; Johannes Buchner
Asymmetric activation of the hsp90 dimer by its cochaperone aha1.
Molecular cell 2010;37(3):344-54.
2009: Marco Retzlaff; Michael Stahl; H Christian Eberl; Stephan Lagleder; Jürgen Beck; Horst Kessler; Johannes Buchner
Hsp90 is regulated by a switch point in the C-terminal domain.
EMBO reports 2009;10(10):1147-53.
2009: Matthias J Feige; Susanne Nath; Silvia R Catharino; Daniel Weinfurtner; Stefan Steinbacher; Johannes Buchner
Structure of the murine unglycosylated IgG1 Fc fragment.
Journal of molecular biology 2009;391(3):599-608.
2009: Otmar Hainzl; Maria Claribel Lapina; Johannes Buchner; Klaus Richter
The charged linker region is an important regulator of Hsp90 function.
The Journal of biological chemistry 2009;284(34):22559-67.
2009: Jirka Peschek; Nathalie Braun; Titus M Franzmann; Yannis Georgalis; Martin Haslbeck; Sevil Weinkauf; Johannes Buchner
The eye lens chaperone alpha-crystallin forms defined globular assemblies.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13272-7.
2009: Matthias J Feige; Sandra Groscurth; Moritz Marcinowski; Yuichiro Shimizu; Horst Kessler; Linda M Hendershot; Johannes Buchner
An unfolded CH1 domain controls the assembly and secretion of IgG antibodies.
Molecular cell 2009;34(5):569-79.
2009: Tetyana Dashivets; Nichole Wood; Christoph Hergersberg; Johannes Buchner; Martin Haslbeck
Rapid matrix-assisted refolding of histidine-tagged proteins.
Chembiochem : a European journal of chemical biology 2009;10(5):869-76.
2009: Moritz Mickler; Martin Hessling; Christoph Ratzke; Johannes Buchner; Thorsten Hugel
The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis.
Nature structural & molecular biology 2009;16(3):281-6.
2009: Martin Hessling; Klaus Richter; Johannes Buchner
Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.
Nature structural & molecular biology 2009;16(3):287-93.
2008: Matthias J Feige; Sandra Groscurth; Moritz Marcinowski; Zu Thur Yew; Vincent Truffault; Emanuele Paci; Horst Kessler; Johannes Buchner
The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13373-8.
2008: Sebastian Karl Wandinger; Klaus Richter; Johannes Buchner
The Hsp90 chaperone machinery.
The Journal of biological chemistry 2008;283(27):18473-7.
2008: Klaus Richter; Joanna Soroka; Lukasz Skalniak; Adriane Leskovar; Martin Hessling; Jochen Reinstein; Johannes Buchner
Conserved conformational changes in the ATPase cycle of human Hsp90.
The Journal of biological chemistry 2008;283(26):17757-65.
2008: Martin Haslbeck; Andreas Kastenmüller; Johannes Buchner; Sevil Weinkauf; Nathalie Braun
Structural dynamics of archaeal small heat shock proteins.
Journal of molecular biology 2008;378(2):362-74.
2008: Adriane Leskovar; Harald Wegele; Nicolas D Werbeck; Johannes Buchner; Jochen Reinstein
The ATPase cycle of the mitochondrial Hsp90 analog Trap1.
The Journal of biological chemistry 2008;283(17):11677-88.
2008: Titus M Franzmann; Petra Menhorn; Stefan Walter; Johannes Buchner
Activation of the chaperone Hsp26 is controlled by the rearrangement of its thermosensor domain.
Molecular cell 2008;29(2):207-16.
2008: Stephan Frey; Martin Haslbeck; Otmar Hainzl; Johannes Buchner
Synthesis and characterization of a functional intact IgG in a prokaryotic cell-free expression system.
Biological chemistry 2008;389(1):37-45.
2007: Elke Janig; Martin Haslbeck; Ariane Aigelsreiter; Nathalie Braun; Daniela Unterthor; Peter Wolf; Noor Mohammad Khaskhely; Johannes Buchner; Helmut Denk; Kurt Zatloukal
Clusterin associates with altered elastic fibers in human photoaged skin and prevents elastin from ultraviolet-induced aggregation in vitro.
The American journal of pathology 2007;171(5):1474-82.
2007: Henriette Bendz; Sibylle C Ruhland; Maya J Pandya; Otmar Hainzl; Stefan Riegelsberger; Christoph Braüchle; Matthias P Mayer; Johannes Buchner; Rolf Issels; Elfriede Noessner
Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling.
The Journal of biological chemistry 2007;282(43):31688-702.
2007: Matthias J Feige; Franz Hagn; Julia Esser; Horst Kessler; Johannes Buchner
Influence of the internal disulfide bridge on the folding pathway of the CL antibody domain.
Journal of molecular biology 2007;365(4):1232-44.
2006: Klaus Richter; Johannes Buchner
hsp90: twist and fold.
Cell 2006;127(2):251-3.
2006: Lin Römer; Christian Klein; Alexander Dehner; Horst Kessler; Johannes Buchner
p53--a natural cancer killer: structural insights and therapeutic concepts.
Angewandte Chemie (International ed. in English) 2006;45(39):6440-60.
2006: Helen E White; Elena V Orlova; Shaoxia Chen; Luchun Wang; Athanasios Ignatiou; Brent Gowen; Thusnelda Stromer; Titus M Franzmann; Martin Haslbeck; Johannes Buchner; Helen R Saibil
Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein Hsp26.
Structure (London, England : 1993) 2006;14(7):1197-204.
2006: Klaus Richter; Sandra Moser; Franz Hagn; Rainer Friedrich; Otmar Hainzl; Markus Heller; Sandra Schlee; Horst Kessler; Jochen Reinstein; Johannes Buchner
Intrinsic inhibition of the Hsp90 ATPase activity.
The Journal of biological chemistry 2006;281(16):11301-11.
2006: Harald Wegele; Sebastian K Wandinger; Andreas B Schmid; Jochen Reinstein; Johannes Buchner
Substrate transfer from the chaperone Hsp70 to Hsp90.
Journal of molecular biology 2006;356(3):802-11.
2006: Sebastian K Wandinger; Michael H Suhre; Harald Wegele; Johannes Buchner
The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90.
The EMBO journal 2006;25(2):367-76.
2006: Thomas Scheibel; Johannes Buchner
Protein aggregation as a cause for disease.
Handbook of experimental pharmacology 2006;(172):199-219.
2005: Lance Shaner; Harald Wegele; Johannes Buchner; Kevin A Morano
The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb.
The Journal of biological chemistry 2005;280(50):41262-9.
2005: Martin Haslbeck; Titus Franzmann; Daniel Weinfurtner; Johannes Buchner
Some like it hot: the structure and function of small heat-shock proteins.
Nature structural & molecular biology 2005;12(10):842-6.
2005: Alexander Dehner; Christian Klein; Silke Hansen; Lin Müller; Johannes Buchner; Manfred Schwaiger; Horst Kessler
Cooperative binding of p53 to DNA: regulation by protein-protein interactions through a double salt bridge.
Angewandte Chemie (International ed. in English) 2005;44(33):5247-51.
2005: Titus M Franzmann; Martin Wühr; Klaus Richter; Stefan Walter; Johannes Buchner
The activation mechanism of Hsp26 does not require dissociation of the oligomer.
Journal of molecular biology 2005;350(5):1083-93.
2005: Martin Haslbeck; Anita Miess; Thusnelda Stromer; Stefan Walter; Johannes Buchner
Disassembling protein aggregates in the yeast cytosol. The cooperation of Hsp26 with Ssa1 and Hsp104.
The Journal of biological chemistry 2005;280(25):23861-8.
2004: Lin Müller; Andreas Schaupp; Dawid Walerych; Harald Wegele; Johannes Buchner
Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
The Journal of biological chemistry 2004;279(47):48846-54.
2004: S. Fabio Falsone; Sebastian Leptihn; Anja Osterauer; Martin Haslbeck; Johannes Buchner
Oncogenic mutations reduce the stability of SRC kinase.
Journal of molecular biology 2004;344(1):281-91.
2004: Matthias J Feige; Stefan Walter; Johannes Buchner
Folding mechanism of the CH2 antibody domain.
Journal of molecular biology 2004;344(1):107-18.
2004: Martin Haslbeck; Athanasios Ignatiou; Helen R Saibil; Sonja Helmich; Elke Frenzl; Thusnelda Stromer; Johannes Buchner
A domain in the N-terminal part of Hsp26 is essential for chaperone function and oligomerization.
Journal of molecular biology 2004;343(2):445-55.
2004: Tobias Gräwert; Johannes Kaiser; Ferdinand Zepeck; Ralf Laupitz; Stefan Hecht; Sabine Amslinger; Nicholas Schramek; Erik Schleicher; Stefan Weber; Martin Haslbeck; Johannes Buchner; Christoph Rieder; Duilio Arigoni; Adelbert Bacher; Wolfgang Eisenreich; Felix Rohdich
IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis.
Journal of the American Chemical Society 2004;126(40):12847-55.
2004: Otmar Hainzl; Harald Wegele; Klaus Richter; Johannes Buchner
Cns1 is an activator of the Ssa1 ATPase activity.
The Journal of biological chemistry 2004;279(22):23267-73.
2004: Floriana Vinci; Silvia Catharino; Stephen Frey; Johannes Buchner; Gennaro Marino; Piero Pucci; Margherita Ruoppolo
Hierarchical formation of disulfide bonds in the immunoglobulin Fc fragment is assisted by protein-disulfide isomerase.
The Journal of biological chemistry 2004;279(15):15059-66.
2004: Thusnelda Stromer; Elke Fischer; Klaus Richter; Martin Haslbeck; Johannes Buchner
Analysis of the regulation of the molecular chaperone Hsp26 by temperature-induced dissociation: the N-terminal domail is important for oligomer assembly and the binding of unfolding proteins.
The Journal of biological chemistry 2004;279(12):11222-8.
2004: Valerie Grimminger; Klaus Richter; Axel imhof; Johannes Buchner; Stefan Walter
The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104.
The Journal of biological chemistry 2004;279(9):7378-83.
2004: Martin Haslbeck; Nathalie Braun; Thusnelda Stromer; Bettina Richter; Natascha Model; Sevil Weinkauf; Johannes Buchner
Hsp42 is the general small heat shock protein in the cytosol of Saccharomyces cerevisiae.
The EMBO journal 2004;23(3):638-49.
2004: Harald Wegele; Lin Müller; Johannes Buchner
Hsp70 and Hsp90--a relay team for protein folding.
Reviews of physiology, biochemistry and pharmacology 2004;151():1-44.
2003: Harald Wegele; Paul Muschler; Melanie Bunck; Jochen Reinstein; Johannes Buchner
Dissection of the contribution of individual domains to the ATPase mechanism of Hsp90.
The Journal of biological chemistry 2003;278(41):39303-10.
2003: Roger Dawson; Lin Müller; Alexander Dehner; Christian Klein; Horst Kessler; Johannes Buchner
The N-terminal domain of p53 is natively unfolded.
Journal of molecular biology 2003;332(5):1131-41.
2003: Alexander Dehner; Julien Furrer; Klaus Richter; Ioana Schuster; Johannes Buchner; Horst Kessler
NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol.
Chembiochem : a European journal of chemical biology 2003;4(9):870-7.
2003: Harald Wegele; Martin Haslbeck; Jochen Reinstein; Johannes Buchner
Sti1 is a novel activator of the Ssa proteins.
The Journal of biological chemistry 2003;278(28):25970-6.
2003: Marcus Mayer; Jochen Reinstein; Johannes Buchner
Modulation of the ATPase cycle of BiP by peptides and proteins.
Journal of molecular biology 2003;330(1):137-44.
2003: Thusnelda Stromer; Monika Ehrnsperger; Matthias Gaestel; Johannes Buchner
Analysis of the interaction of small heat shock proteins with unfolding proteins.
The Journal of biological chemistry 2003;278(20):18015-21.
2003: Harald Wegele; Martin Haslbeck; Johannes Buchner
Recombinant expression and purification of Ssa1p (Hsp70) from Saccharomyces cerevisiae using Pichia pastoris.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;786(1-2):109-15.
2003: Klaus Richter; Paul Muschler; Otmar Hainzl; Jochen Reinstein; Johannes Buchner
Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle.
The Journal of biological chemistry 2003;278(12):10328-33.
2002: Klaus Richter; Jochen Reinstein; Johannes Buchner
N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle.
The Journal of biological chemistry 2002;277(47):44905-10.
2002: Stefan Bell; Christian Klein; Lin Müller; Silke Hansen; Johannes Buchner
p53 contains large unstructured regions in its native state.
Journal of molecular biology 2002;322(5):917-27.
2002: Michael J W Thies; Fabio Talamo; Marcus Mayer; Stefan Bell; Margherita Ruoppolo; Gennaro Marino; Johannes Buchner
Folding and oxidation of the antibody domain C(H)3.
Journal of molecular biology 2002;319(5):1267-77.
2002: Johannes Buchner; Rainer Rudolph; Hauke Lilie
Intradomain disulfide bonds impede formation of the alternatively folded state of antibody chains.
Journal of molecular biology 2002;318(3):829-36.
2002: Gerhard Knarr; Ursula Kies; Stefan Bell; Marcus Mayer; Johannes Buchner
Interaction of the chaperone BiP with an antibody domain: implications for the chaperone cycle.
Journal of molecular biology 2002;318(3):611-20.
2002: Isaac Kurek; Franziska Pirkl; Elke Fischer; Johannes Buchner; Adina Breiman
Wheat FKBP73 functions in vitro as a molecular chaperone independently of its peptidyl prolyl cis-trans isomerase activity.
Planta 2002;215(1):119-26.
2002: Stefan Walter; Johannes Buchner
Molecular chaperones--cellular machines for protein folding.
Angewandte Chemie (International ed. in English) 2002;41(7):1098-113.
2002: Martin Haslbeck; Johannes Buchner
Chaperone function of sHsps.
Progress in molecular and subcellular biology 2002;28():37-59.
2001: Franziska Pirkl; E Fischer; S Modrow; Johannes Buchner
Localization of the chaperone domain of FKBP52.
The Journal of biological chemistry 2001;276(40):37034-41.
2001: Klaus Richter; Paul Muschler; Otmar Hainzl; Johannes Buchner
Coordinated ATP hydrolysis by the Hsp90 dimer.
The Journal of biological chemistry 2001;276(36):33689-96.
2001: Klaus Richter; Johannes Buchner
Hsp90: chaperoning signal transduction.
Journal of cellular physiology 2001;188(3):281-90.
2001: Holger Grallert; Johannes Buchner
Review: a structural view of the GroE chaperone cycle.
Journal of structural biology 2001;135(2):95-103.
2001: Michael J W Thies; R Kammermeier; K Richter; Johannes Buchner
The alternatively folded state of the antibody C(H)3 domain.
Journal of molecular biology 2001;309(5):1077-85.
2001: Franziska Pirkl; Johannes Buchner
Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40.
Journal of molecular biology 2001;308(4):795-806.
2001: J G Augustine; A de La Calle; Gerhard Knarr; Johannes Buchner; Christin A Frederick
The crystal structure of the fab fragment of the monoclonal antibody MAK33. Implications for folding and interaction with the chaperone bip.
The Journal of biological chemistry 2001;276(5):3287-94.
2000: T Weikl; Paul Muschler; Klaus Richter; Thomas Veit; Jochen Reinstein; Johannes Buchner
C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle.
Journal of molecular biology 2000;303(4):583-92.
2000: Christine Mayr; Klaus Richter; Hauke Lilie; Johannes Buchner
Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties.
The Journal of biological chemistry 2000;275(44):34140-6.
2000: M Mayer; U Kies; R Kammermeier; Johannes Buchner
BiP and PDI cooperate in the oxidative folding of antibodies in vitro.
The Journal of biological chemistry 2000;275(38):29421-5.
2000: Holger Grallert; K Rutkat; Johannes Buchner
Limits of protein folding inside GroE complexes.
The Journal of biological chemistry 2000;275(27):20424-30.
2000: Robyn A Lindner; John A Carver; Monika Ehrnsperger; Johannes Buchner; G Esposito; Joachim Behlke; Gudrun Lutsch; Alexey Kotlyarov; M Gaestel
Mouse Hsp25, a small shock protein. The role of its C-terminal extension in oligomerization and chaperone action.
European journal of biochemistry / FEBS 2000;267(7):1923-32.
2000: Monika Ehrnsperger; Matthias Gaestel; Johannes Buchner
Analysis of chaperone properties of small Hsp's.
Methods in molecular biology (Clifton, N.J.) 2000;99():421-9.
1999: Martin Haslbeck; S Walke; Thusnelda Stromer; Monika Ehrnsperger; Helen E White; S Chen; Helen R Saibil; Johannes Buchner
Hsp26: a temperature-regulated chaperone.
The EMBO journal 1999;18(23):6744-51.
1999: Thomas Scheibel; T Weikl; R Rimerman; David Smith; Susan Lindquist; Johannes Buchner
Contribution of N- and C-terminal domains to the function of Hsp90 in Saccharomyces cerevisiae.
Molecular microbiology 1999;34(4):701-13.
1999: T Weikl; K Abelmann; Johannes Buchner
An unstructured C-terminal region of the Hsp90 co-chaperone p23 is important for its chaperone function.
Journal of molecular biology 1999;293(3):685-91.
1999: Gerhard Knarr; Susanne Modrow; A Todd; Mary-Jane Gething; Johannes Buchner
BiP-binding sequences in HIV gp160. Implications for the binding specificity of bip.
The Journal of biological chemistry 1999;274(42):29850-7.
1999: Michael J W Thies; J Mayer; J G Augustine; Christin A Frederick; Hauke Lilie; Johannes Buchner
Folding and association of the antibody domain CH3: prolyl isomerization preceeds dimerization.
Journal of molecular biology 1999;293(1):67-79.
1999: Holger Grallert; Johannes Buchner
Analysis of GroE-assisted folding under nonpermissive conditions.
The Journal of biological chemistry 1999;274(29):20171-7.
1999: T Rogalla; Monika Ehrnsperger; X Preville; Alexey Kotlyarov; Gudrun Lutsch; Cécile Ducasse; C Paul; M Wieske; André-Patrick Arrigo; Johannes Buchner; Matthias Gaestel
Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.
The Journal of biological chemistry 1999;274(27):18947-56.
1999: M Beissinger; K Rutkat; Johannes Buchner
Catalysis, commitment and encapsulation during GroE-mediated folding.
Journal of molecular biology 1999;289(4):1075-92.
1999: Monika Ehrnsperger; H Lilie; Matthias Gaestel; Johannes Buchner
The dynamics of Hsp25 quaternary structure. Structure and function of different oligomeric species.
The Journal of biological chemistry 1999;274(21):14867-74.
1999: Johannes Buchner
Hsp90 & Co. - a holding for folding.
Trends in biochemical sciences 1999;24(4):136-41.
1999: Thomas Scheibel; H I Siegmund; Rainer Jaenicke; P Ganz; H Lilie; Johannes Buchner
The charged region of Hsp90 modulates the function of the N-terminal domain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1297-302.
1998: Holger Grallert; K Rutkat; Johannes Buchner
GroEL traps dimeric and monomeric unfolding intermediates of citrate synthase.
The Journal of biological chemistry 1998;273(50):33305-10.
1998: A Nichtl; Johannes Buchner; Rainer Jaenicke; Rainer Rudolph; Thomas Scheibel
Folding and association of beta-Galactosidase.
Journal of molecular biology 1998;282(5):1083-91.
1998: Thomas Scheibel; Johannes Buchner
The Hsp90 complex--a super-chaperone machine as a novel drug target.
Biochemical pharmacology 1998;56(6):675-82.
1998: Monika Ehrnsperger; C Hergersberg; U Wienhues; A Nichtl; Johannes Buchner
Stabilization of proteins and peptides in diagnostic immunological assays by the molecular chaperone Hsp25.
Analytical biochemistry 1998;259(2):218-25.
1998: M Beissinger; Johannes Buchner
How chaperones fold proteins.
Biological chemistry 1998;379(3):245-59.
1998: Thomas Scheibel; T Weikl; Johannes Buchner
Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1495-9.
1998: Johannes Buchner; T Weikl; H Bügl; Franziska Pirkl; S Bose
Purification of Hsp90 partner proteins Hop/p60, p23, and FKBP52.
Methods in enzymology 1998;290():418-29.
1998: Johannes Buchner; S Bose; C Mayr; Ursula Jakob
Purification and characterization of prokaryotic and eukaryotic Hsp90.
Methods in enzymology 1998;290():409-18.
1998: Johannes Buchner; Monika Ehrnsperger; Matthias Gaestel; S Walke
Purification and characterization of small heat shock proteins.
Methods in enzymology 1998;290():339-49.
1998: Johannes Buchner; Holger Grallert; Ursula Jakob
Analysis of chaperone function using citrate synthase as nonnative substrate protein.
Methods in enzymology 1998;290():323-38.
1997: Thomas Scheibel; S Neuhofen; T Weikl; C Mayr; Jochen Reinstein; Pia Vogel; Johannes Buchner
ATP-binding properties of human Hsp90.
The Journal of biological chemistry 1997;272(30):18608-13.
1997: H Sparrer; Johannes Buchner
How GroES regulates binding of nonnative protein to GroEL.
The Journal of biological chemistry 1997;272(22):14080-6.
1997: H Sparrer; K Rutkat; Johannes Buchner
Catalysis of protein folding by symmetric chaperone complexes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1096-100.
1997: Monika Ehrnsperger; S Gräber; Matthias Gaestel; Johannes Buchner
Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.
The EMBO journal 1997;16(2):221-9.
1996: S Bose; T Weikl; H Bügl; Johannes Buchner
Chaperone function of Hsp90-associated proteins.
Science (New York, N.Y.) 1996;274(5293):1715-7.
1996: Ursula Jakob; Thomas Scheibel; S Bose; Jochen Reinstein; Johannes Buchner
Assessment of the ATP binding properties of Hsp90.
The Journal of biological chemistry 1996;271(17):10035-41.
1996: H Sparrer; H Lilie; Johannes Buchner
Dynamics of the GroEL-protein complex: effects of nucleotides and folding mutants.
Journal of molecular biology 1996;258(1):74-87.
1996: Johannes Buchner
Supervising the fold: functional principles of molecular chaperones.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(1):10-9.
1995: G Knarr; Mary-Jane Gething; S Modrow; Johannes Buchner
BiP binding sequences in antibodies.
The Journal of biological chemistry 1995;270(46):27589-94.
1995: H Lilie; Johannes Buchner
Interaction of GroEL with a highly structured folding intermediate: iterative binding cycles do not involve unfolding.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8100-4.
1995: Paul V Viitanen; Marion Schmidt; Johannes Buchner; T Suzuki; E Vierling; R Dickson; G H Lorimer; A Gatenby; Jürgen Soll
Functional characterization of the higher plant chloroplast chaperonins.
The Journal of biological chemistry 1995;270(30):18158-64.
1995: Ursula Jakob; I Meyer; H Bügl; S André; James C A Bardwell; Johannes Buchner
Structural organization of procaryotic and eucaryotic Hsp90. Influence of divalent cations on structure and function.
The Journal of biological chemistry 1995;270(24):14412-9.
1995: H Lilie; Rainer Jaenicke; Johannes Buchner
Characterization of a quaternary-structured folding intermediate of an antibody Fab-fragment.
Protein science : a publication of the Protein Society 1995;4(5):917-24.
1995: H Lilie; R Rudolph; Johannes Buchner
Association of antibody chains at different stages of folding: prolyl isomerization occurs after formation of quaternary structure.
Journal of molecular biology 1995;248(1):190-201.
1995: Ursula Jakob; H Lilie; I Meyer; Johannes Buchner
Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo.
The Journal of biological chemistry 1995;270(13):7288-94.
1995: H Lilie; Johannes Buchner
Domain interactions stabilize the alternatively folded state of an antibody Fab fragment.
FEBS letters 1995;362(1):43-6.
1995: S Bose; H Lilie; Johannes Buchner; Robert B Freedman
The in vitro catalysis of protein folding by endoplasmic reticulum luminal peptidyl prolyl cis-trans isomerase.
Biochemical Society transactions 1995;23(1):63S.
1994: Marion Schmidt; U Bücheler; B Kaluza; Johannes Buchner
Correlation between the stability of the GroEL-protein ligand complex and the release mechanism.
The Journal of biological chemistry 1994;269(45):27964-72.
1994: Marion Schmidt; K Rutkat; Reinhard Rachel; G Pfeifer; Rainer Jaenicke; Paul V Viitanen; G Lorimer; Johannes Buchner
Symmetric complexes of GroE chaperonins as part of the functional cycle.
Science (New York, N.Y.) 1994;265(5172):656-9.
1994: H Lilie; Stephen McLaughlin; R Freedman; Johannes Buchner
Influence of protein disulfide isomerase (PDI) on antibody folding in vitro.
The Journal of biological chemistry 1994;269(19):14290-6.
1994: Ursula Jakob; Johannes Buchner
Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones.
Trends in biochemical sciences 1994;19(5):205-11.
1994: Marion Schmidt; Johannes Buchner; M J Todd; G H Lorimer; Paul V Viitanen
On the role of groES in the chaperonin-assisted folding reaction. Three case studies.
The Journal of biological chemistry 1994;269(14):10304-11.
1994: U Knauf; Ursula Jakob; K Engel; Johannes Buchner; Matthias Gaestel
Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.
The EMBO journal 1994;13(1):54-60.
1993: H Lilie; K Lang; R Rudolph; Johannes Buchner
Prolyl isomerases catalyze antibody folding in vitro.
Protein science : a publication of the Protein Society 1993;2(9):1490-6.
1993: H Wiech; Johannes Buchner; M Zimmermann; Richard Zimmermann; Ursula Jakob
Hsc70, immunoglobulin heavy chain binding protein, and Hsp90 differ in their ability to stimulate transport of precursor proteins into mammalian microsomes.
The Journal of biological chemistry 1993;268(10):7414-21.
1993: Ursula Jakob; Matthias Gaestel; K Engel; Johannes Buchner
Small heat shock proteins are molecular chaperones.
The Journal of biological chemistry 1993;268(3):1517-20.
1992: Marion Schmidt; Johannes Buchner
Interaction of GroE with an all-beta-protein.
The Journal of biological chemistry 1992;267(24):16829-33.
1992: H Wiech; Johannes Buchner; Richard Zimmermann; Ursula Jakob
Hsp90 chaperones protein folding in vitro.
Nature 1992;358(6382):169-70.
1992: Gunther Kern; Marion Schmidt; Johannes Buchner; Rainer Jaenicke
Glycosylation inhibits the interaction of invertase with the chaperone GroEL.
FEBS letters 1992;305(3):203-5.
1991: T Kiefhaber; R Rudolph; H H Kohler; Johannes Buchner
Protein aggregation in vitro and in vivo: a quantitative model of the kinetic competition between folding and aggregation.
Bio/technology (Nature Publishing Company) 1991;9(9):825-9.
1991: Johannes Buchner; M Renner; H Lilie; Hans-Jürgen Hinz; Rainer Jaenicke; T Kiefhabel; R Rudolph
Alternatively folded states of an immunoglobulin.
Biochemistry 1991;30(28):6922-9.
1991: Johannes Buchner; Marion Schmidt; M Fuchs; Rainer Jaenicke; R Rudolph; Franz X Schmid; T Kiefhaber
GroE facilitates refolding of citrate synthase by suppressing aggregation.
Biochemistry 1991;30(6):1586-91.
1991: Johannes Buchner; R Rudolph
Renaturation, purification and characterization of recombinant Fab-fragments produced in Escherichia coli.
Bio/technology (Nature Publishing Company) 1991;9(2):157-62.
1990: Johannes Buchner; T Kiefhaber
Folding pathway enigma.
Nature 1990;343(6259):601-2.