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Sebastian Brandner

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Shaheen Akhtar; Sebastian Brandner; John Collinge; Mar Fernandez de Marco; Julia Grizenkova; Holger Hummerich; Adam Wenborn; Sarah E Lloyd
Sod1 deficiency reduces incubation time in mouse models of prion disease.
Julia Grizenkova; Holger Hummerich; Shaheen Akhtar; Emmanuel A Asante; Sebastian Brandner; John Collinge; Elizabeth M C Fisher; Jérémie Fizet; Mark Poulter; Andrew Tomlinson; Victor L J Tybulewicz; Adam Wenborn; Frances K Wiseman; Sarah E Lloyd
Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.
Olivia Sheppard; Amy Slender; Victor L J Tybulewicz; Sebastian Brandner; Elizabeth M C Fisher; Jacqueline M Linehan; Florian Plattner; Anna Rubin; Frances K Wiseman
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.

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2013: Shaheen Akhtar; Sebastian Brandner; John Collinge; Mar Fernandez de Marco; Julia Grizenkova; Holger Hummerich; Adam Wenborn; Sarah E Lloyd
Sod1 deficiency reduces incubation time in mouse models of prion disease.
PloS one 2013;8(1):e54454.
2012: Julia Grizenkova; Holger Hummerich; Shaheen Akhtar; Emmanuel A Asante; Sebastian Brandner; John Collinge; Elizabeth M C Fisher; Jérémie Fizet; Mark Poulter; Andrew Tomlinson; Victor L J Tybulewicz; Adam Wenborn; Frances K Wiseman; Sarah E Lloyd
Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(34):13722-7.
2012: Olivia Sheppard; Amy Slender; Victor L J Tybulewicz; Sebastian Brandner; Elizabeth M C Fisher; Jacqueline M Linehan; Florian Plattner; Anna Rubin; Frances K Wiseman
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Neurobiology of aging 2012;33(4):828.e31-44.
2012: Shabnam Ghazi-Noori; Emmanuel A Asante; Sebastian Brandner; John Collinge; Michael Farmer; Mar Fernandez de Marco; Elizabeth M C Fisher; Kristina E Froud; Sarah Mizielinska; Catherine O'Malley; Nick Parkinson; Caroline Powell; Michelle Smidak; Adrian M Isaacs
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.
Brain : a journal of neurology 2012;135(Pt 3):819-32.
2012: Harpreet Hyare; Anil Ramlackhansingh; Peter Rudge; Sebastian Brandner; David J Brooks; John Collinge; Paul Edison; Giorgio Gelosa; Simon Mead
11C-PiB PET does not detect PrP-amyloid in prion disease patients including variant Creutzfeldt-Jakob disease.
Journal of neurology, neurosurgery, and psychiatry 2012;83(3):340-1.
2012: Rocio Castro-Seoane; John Collinge; Mar Fernandez de Marco; Holger Hummerich; Jacqueline M Linehan; Trevor Sweeting; M Howard Tattum; Sebastian Brandner; Peter-Christian Klöhn
Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.
PLoS pathogens 2012;8(2):e1002538.
2012: Joachim Weis; Sebastian Brandner; Martin Lammens; Claudia Sommer; Jean-Michel Vallat
Processing of nerve biopsies: a practical guide for neuropathologists.
Clinical neuropathology 2012;31(1):7-23.
2011: Diego N Kaski; Catherine Pennington; Jon Beck; Mark Poulter; James Uphill; Matthew T Bishop; Jaqueline M Linehan; Catherine O'Malley; Jonathan D F Wadsworth; Susan Joiner; Richard S G Knight; James W Ironside; Sebastian Brandner; John Collinge; simon mead
Inherited prion disease with 4-octapeptide repeat insertion: disease requires the interaction of multiple genetic risk factors.
Brain : a journal of neurology 2011;134(Pt 6):1829-38.
2011: Gareth T Banks; Matilda A Haas; Samantha Line; Hazel L Shepherd; Mona Alqatari; Sammy Stewart; Ida Rishal; Amelia Philpott; Bernadett Kalmar; Anna Kuta; Michael Groves; Nicholas Parkinson; Abraham Acevedo-Arozena; Sebastian Brandner; David Bannerman; Linda Greensmith; Majid Hafezparast; Martin Koltzenburg; Robert Deacon; Mike Fainzilber; Elizabeth M C Fisher
Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(14):5483-94.
2011: Sinéad M Murphy; James Polke; Hadi Manji; Julian Blake; Lilla Reiniger; Mary Sweeney; Henry Houlden; Sebastian Brandner; Mary M Reilly
A novel mutation in the nerve-specific 5'UTR of the GJB1 gene causes X-linked Charcot-Marie-Tooth disease.
Journal of the peripheral nervous system : JPNS 2011;16(1):65-70.
2011: Jonathan D F Wadsworth; Inmaculada Dalmau-Mena; Susan Joiner; Jacqueline M Linehan; Catherine O'Malley; Caroline Powell; Sebastian Brandner; Emmanuel A Asante; James W Ironside; David A Hilton; John Collinge
Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study.
The Journal of pathology 2011;223(4):511-8.
2011: Julie Ann Edgeworth; Anita Sicilia; Jackie Linehan; Sebastian Brandner; Graham S Jackson; John Collinge
A standardized comparison of commercially available prion decontamination reagents using the Standard Steel-Binding Assay.
The Journal of general virology 2011;92(Pt 3):718-26.
2011: Tabish A Saifee; Mary M Reilly; Emmanuel Ako; Fergus Rugg-Gunn; Sebastian Brandner; Michael P Lunn; Siobhan M Leary
Sarcoidosis presenting as acute inflammatory demyelinating polyradiculoneuropathy.
Muscle & nerve 2011;43(2):296-8.
2011: Anna Sadnicka; Mary M Reilly; Cath Mummery; Sebastian Brandner; Nicholas Hirsch; M P T Lunn
Rituximab in the treatment of three coexistent neurological autoimmune diseases: chronic inflammatory demyelinating polyradiculoneuropathy, Morvan syndrome and myasthenia gravis.
Journal of neurology, neurosurgery, and psychiatry 2011;82(2):230-2.
2011: Sebastian Brandner
Diversity of prion diseases: (no) strains attached?
Acta neuropathologica 2011;121(1):1-4.
2011: Lilla Reiniger; Ana Lukic; Jacqueline Linehan; Peter Rudge; John Collinge; Simon Mead; Sebastian Brandner
Tau, prions and Aβ: the triad of neurodegeneration.
Acta neuropathologica 2011;121(1):5-20.
2010: Mar Fernandez de Marco; Jacqueline Linehan; O Noel Gill; Jonathan P Clewley; Sebastian Brandner
Large-scale immunohistochemical examination for lymphoreticular prion protein in tonsil specimens collected in Britain.
The Journal of pathology 2010;222(4):380-7.
2010: Klaus Schmierer; Janet R Thavarajah; Shu F An; Sebastian Brandner; David H Miller; Daniel J Tozer
Effects of formalin fixation on magnetic resonance indices in multiple sclerosis cortical gray matter.
Journal of magnetic resonance imaging : JMRI 2010;32(5):1054-60.
2010: Joerg D Hoeck; Anett Jandke; Sophia M Blake; Emma Nye; Bradley Spencer-Dene; Sebastian Brandner; Axel Behrens
Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.
Nature neuroscience 2010;13(11):1365-72.
2010: Durrenajaf Siddique; Harpreet Hyare; Stephen J Wroe; Thomas Webb; Rebecca Macfarlane; Peter Rudge; John Collinge; Caroline Powell; Sebastian Brandner; Po-Wah So; Sarah Walker; simon mead; Tarek A Yousry; John S Thornton
Magnetization transfer ratio may be a surrogate of spongiform change in human prion diseases.
Brain : a journal of neurology 2010;133(10):3058-68.
2010: Malin K Sandberg; Huda Al-Doujaily; Christina J Sigurdson; Markus Glatzel; Catherine O'Malley; Caroline Powell; Emmanuel A Asante; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein.
The Journal of general virology 2010;91(Pt 10):2651-7.
2010: Coro Paisan-Ruiz; Rocio Guevara; Monica Federoff; Hasmet Hanagasi; Fardaz Sina; Elahe Elahi; Susanne A Schneider; Petra Schwingenschuh; Nin Bajaj; Murat Emre; Andrew Singleton; John Hardy; Kailash P Bhatia; Sebastian Brandner; Andrew J Lees; Henry Houlden
Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations.
Movement disorders : official journal of the Movement Disorder Society 2010;25(12):1791-800.
2010: Jonathan M Schott; Lilla Reiniger; Maria Thom; Janice L Holton; Joan Grieve; Sebastian Brandner; Jason D Warren; Tamas Revesz
Brain biopsy in dementia: clinical indications and diagnostic approach.
Acta neuropathologica 2010;120(3):327-41.
2010: Sebastian Brandner
Nanog, Gli, and p53: a new network of stemness in development and cancer.
The EMBO journal 2010;29(15):2475-6.
2010: Frances K Wiseman; Olivia Sheppard; Jacqueline M Linehan; Sebastian Brandner; Victor L J Tybulewicz; Elizabeth M C Fisher
Generation of a panel of antibodies against proteins encoded on human chromosome 21.
Journal of negative results in biomedicine 2010;9():7.
2009: T Webb; simon mead; Jon Beck; J Uphill; S Pal; S Hampson; J D F Wadsworth; I Dalmau Mena; C O'Malley; Stephen J Wroe; A Schapira; Sebastian Brandner; John Collinge
Seven-year discordance in age at onset in monozygotic twins with inherited prion disease (P102L).
Neuropathology and applied neurobiology 2009;35(4):427-32.
2009: Emmanuel A Asante; Ian Gowland; Andrew Grimshaw; Jacqueline M Linehan; Michelle Smidak; Richard Houghton; Olufunmilayo Osiguwa; Andrew Tomlinson; Susan Joiner; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins.
The Journal of general virology 2009;90(Pt 3):546-58.
2008: Sebastian Brandner; Jerome Whitfield; Ken Boone; Anderson Puwa; Catherine O'Malley; Jacqueline M Linehan; Susan Joiner; Francesco Scaravilli; Ian Calder; Michael P Alpers; Jonathan D F Wadsworth; John Collinge
Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3755-63.
2008: Jonathan D F Wadsworth; Susan Joiner; Jacqueline M Linehan; Emmanuel A Asante; Sebastian Brandner; John Collinge
Review. The origin of the prion agent of kuru: molecular and biological strain typing.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3747-53.
2008: John Collinge; Jerome Whitfield; Edward McKintosh; Adam Frosh; simon mead; Andrew Hill; Sebastian Brandner; Dafydd Thomas; Michael P Alpers
A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New Guinea.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3725-39.
2008: T E F Webb; M Poulter; J Beck; J Uphill; G Adamson; T Campbell; J Linehan; C Powell; Sebastian Brandner; S Pal; D Siddique; J D Wadsworth; S Joiner; K Alner; C Petersen; S Hampson; C Rhymes; C Treacy; E Storey; M D Geschwind; A H Nemeth; S Wroe; J Collinge; simon mead
Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series.
Brain : a journal of neurology 2008;131(Pt 10):2632-46.
2008: Thomas E F Webb; Suvankar Pal; Durrenajaf Siddique; Dominic C Heaney; Jacqueline M Linehan; Jonathan D F Wadsworth; Susan Joiner; Jon Beck; Stephen J Wroe; Valerie Stevenson; Sebastian Brandner; simon mead; John Collinge
First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation.
Journal of neuropathology and experimental neurology 2008;67(9):838-41.
2008: Marie O'Shea; Emma G Maytham; Jacqueline M Linehan; Sebastian Brandner; John Collinge; Sarah E Lloyd
Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse.
Genetics 2008;180(1):559-66.
2008: A M Isaacs; C Powell; T E Webb; J M Linehan; J Collinge; Sebastian Brandner
Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases.
Neuropathology and applied neurobiology 2008;34(4):446-56.
2008: Melanie D White; Michael Farmer; Ilaria Mirabile; Sebastian Brandner; John Collinge; Giovanna R Mallucci
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):10238-43.
2008: Jonathan D F Wadsworth; Susan Joiner; Jacqueline M Linehan; Melanie Desbruslais; Katie Fox; Sharon Cooper; Sabrina Cronier; Emmanuel A Asante; simon mead; Sebastian Brandner; Andrew Hill; John Collinge
Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3885-90.
2008: Jonathan D F Wadsworth; Caroline Powell; Jonathan A Beck; Susan Joiner; Jacqueline M Linehan; Sebastian Brandner; simon mead; John Collinge
Molecular diagnosis of human prion disease.
Methods in molecular biology (Clifton, N.J.) 2008;459():197-227.
2008: Claudia Sommer; Sebastian Brandner; P J Dyck; L Magy; S I Mellgren; M Morbin; A Schenone; E Tan; J Weis
147th ENMC international workshop: guideline on processing and evaluation of sural nerve biopsies, 15-17 December 2006, Naarden, The Netherlands.
Neuromuscular disorders : NMD 2008;18(1):90-6.
2007: Abdolrahman S Nateri; Gennadij Raivich; Christine Gebhardt; Clive Da Costa; Heike Naumann; Martin Vreugdenhil; Milan Makwana; Sebastian Brandner; Ralf H Adams; John Jefferys; Oliver Kann; Axel Behrens
ERK activation causes epilepsy by stimulating NMDA receptor activity.
The EMBO journal 2007;26(23):4891-901.
2007: Naushaba Nayeem; Fiona Kerr; Heike Naumann; Jackie Linehan; Simon Lovestone; Sebastian Brandner
Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella.
Molecular and cellular neurosciences 2007;34(3):400-8.
2007: Giovanna Mallucci; Melanie D White; Michael Farmer; Andrew Dickinson; Husna Khatun; Andrew D Powell; Sebastian Brandner; John Jefferys; John Collinge
Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice.
Neuron 2007;53(3):325-35.
2007: Afua Mensah; Claire Mulligan; Jacqueline M Linehan; Sandra Ruf; Aideen O'Doherty; Beata Grygalewicz; Janet Shipley; Jürgen Groet; Victor L J Tybulewicz; Elizabeth Fisher; Sebastian Brandner; Dean Nizetic
An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model.
BMC developmental biology 2007;7():131.
2007: Jonathan D F Wadsworth; Susan Joiner; K Fox; Jacqueline M Linehan; Melanie Desbruslais; Sebastian Brandner; Emmanuel A Asante; John Collinge
Prion infectivity in variant Creutzfeldt-Jakob disease rectum.
Gut 2007;56(1):90-4.
2006: Stephen J Wroe; Suvankar Pal; Durrenajaf Siddique; Harpreet Hyare; Rebecca Macfarlane; Susan Joiner; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; Patricia Hewitt; John Collinge
Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report.
Lancet 2006;368(9552):2061-7.
2006: Emmanuel A Asante; Jacqueline M Linehan; Ian Gowland; Susan Joiner; Katie Fox; Sharon Cooper; Olufumilayo Osiguwa; Michelle Gorry; Julie Welch; Richard Houghton; Melanie Desbruslais; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Dissociation of pathological and molecular phenotype of variant Creutzfeldt-Jakob disease in transgenic human prion protein 129 heterozygous mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10759-64.
2006: Jonathan D F Wadsworth; Susan Joiner; Jacqueline M Linehan; Sharon Cooper; Caroline Powell; Gary Mallinson; Jennifer Buckell; Ian Gowland; Emmanuel A Asante; Herbert Budka; Sebastian Brandner; John Collinge
Phenotypic heterogeneity in inherited prion disease (P102L) is associated with differential propagation of protease-resistant wild-type and mutant prion protein.
Brain : a journal of neurology 2006;129(Pt 6):1557-69.
2006: Fiona Kerr; Annika Rickle; Naushaba Nayeem; Sebastian Brandner; Richard Frank Cowburn; Simon Lovestone
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3.
FEBS letters 2006;580(13):3121-8.
2005: Mark Kristiansen; Marcus J Messenger; Peter-Christian Klöhn; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge; Sarah J Tabrizi
Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis.
The Journal of biological chemistry 2005;280(46):38851-61.
2005: Susan Joiner; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
High levels of disease related prion protein in the ileum in variant Creutzfeldt-Jakob disease.
Gut 2005;54(10):1506-8.
2005: Aideen O'Doherty; Sandra Ruf; Claire Mulligan; Victoria Hildreth; Mick L Errington; Sam F Cooke; Abdul Sesay; Sonie A C Modino; Lesley Vanes; Diana Hernandez; Jacqueline M Linehan; Paul T Sharpe; Sebastian Brandner; T V P Bliss; Deborah J Henderson; Dean Nizetic; Victor L J Tybulewicz; Elizabeth M C Fisher
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
Science (New York, N.Y.) 2005;309(5743):2033-7.
2005: Alexei I Korenkov; Hans G Imhof; Sebastian Brandner; Ethan Taub; Pia Huguenin; Michael R Gaab; Yasuhiro Yonekawa
Growth retardation and bilateral cataracts followed by anaplastic meningioma 23 years after high-dose cranial and whole-body irradiation for acute lymphoblastic leukemia: case report and review of the literature.
Journal of neuro-oncology 2005;74(2):195-9.
2005: Gaia Skibinski; Nicholas J Parkinson; Jeremy M Brown; Lisa Chakrabarti; Sarah L Lloyd; Holger Hummerich; Jørgen E Nielsen; John R Hodges; Maria Grazia Spillantini; Tove Thusgaard; Sebastian Brandner; Arne Brun; Martin N Rossor; Anders Gade; Peter Johannsen; Sven Asger Sørensen; Susanne Gydesen; Elizabeth M C Fisher; John Collinge
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia.
Nature genetics 2005;37(8):806-8.
2005: Graham S Jackson; Edward McKintosh; Eckhard Flechsig; Kanella Prodromidou; Petra Hirsch; Jacqueline M Linehan; Sebastian Brandner; Anthony R Clarke; Charles Weissmann; John Collinge
An enzyme-detergent method for effective prion decontamination of surgical steel.
The Journal of general virology 2005;86(Pt 3):869-78.
2005: Majid Hafezparast; Sebastian Brandner; Jacqueline M Linehan; Joanne E Martin; John Collinge; Elizabeth M C Fisher
Prion disease incubation time is not affected in mice heterozygous for a dynein mutation.
Biochemical and biophysical research communications 2005;326(1):18-22.
2004: Jonathan D F Wadsworth; Emmanuel A Asante; Melanie Desbruslais; Jacqueline M Linehan; Susan Joiner; Ian Gowland; Julie Welch; Lisa Stone; Sarah E Lloyd; Andrew Hill; Sebastian Brandner; John Collinge
Human prion protein with valine 129 prevents expression of variant CJD phenotype.
Science (New York, N.Y.) 2004;306(5702):1793-6.
2004: L Miguel Martins; Alastair Morrison; Kristina Klupsch; Valentina Fedele; Nicoleta Moisoi; Peter Teismann; Alejandro Abuin; Evelyn Grau; Martin Geppert; George P Livi; Caretha L Creasy; Alison Martin; Iain P Hargreaves; Simon J R Heales; Hitoshi Okada; Sebastian Brandner; Jörg B Schulz; Tak Mak; Julian Downward
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
Molecular and cellular biology 2004;24(22):9848-62.
2004: Adam Frosh; Lorraine C Smith; Carl J Jackson; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Analysis of 2000 consecutive UK tonsillectomy specimens for disease-related prion protein.
Lancet 2004;364(9441):1260-2.
2004: Sarah E Lloyd; Jacqueline M Linehan; Melanie Desbruslais; Susan Joiner; Jennifer Buckell; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Characterization of two distinct prion strains derived from bovine spongiform encephalopathy transmissions to inbred mice.
The Journal of general virology 2004;85(Pt 8):2471-8.
2004: Sonja Horstmann; Arie Perry; Guido Reifenberger; Felice Giangaspero; Herve Huang; Akira Hara; Jun Masuoka; Nikolai G Rainov; Markus Bergmann; Frank L Heppner; Sebastian Brandner; Leila Chimelli; Nádia Montagna; Thad Jackson; Daron G Davis; William R Markesbery; David W Ellison; Roy O Weller; Gian L Taddei; Renato Conti; Marc R Del Bigio; Ricardo González-Cámpora; V V Radhakrishnan; Figen Söylemezoglu; Emmanuelle Uro-Coste; Jiang Qian; Paul Kleihues; Hiroko Ohgaki
Genetic and expression profiles of cerebellar liponeurocytomas.
Brain pathology (Zurich, Switzerland) 2004;14(3):281-9.
2004: Boris P Eckhardt; Sebastian Brandner; Christoph L Zollikofer; Klaus U Wentz
Primary cerebral leiomyosarcoma in a child.
Pediatric radiology 2004;34(6):495-8.
2004: Sarah E Lloyd; Simon R Thompson; Jonathan A Beck; Jacqueline M Linehan; Jonathan D F Wadsworth; Sebastian Brandner; John Collinge; Elizabeth M C Fisher
Identification and characterization of a novel mouse prion gene allele.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(5):383-9.
2004: B Himmelmann; Sebastian Brandner; H H Jung; Gabriele Schoedon; B Schuknecht; Andreas Schaffner
Severe hypothermia in a patient with cerebral relapse of Whipple's disease.
Infection 2004;32(2):119-21.
2004: Lucy Anderson; Daniela Rossi; Jacqueline M Linehan; Sebastian Brandner; Charles Weissmann
Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3644-9.
2004: Fabian Baumann; Miroslava Bjeljac; Spyros S Kollias; Brigitta Baumert; Sebastian Brandner; Valentin Rousson; Yasuhiro Yonekawa; René Bernays
Combined thalidomide and temozolomide treatment in patients with glioblastoma multiforme.
Journal of neuro-oncology 2004;67(1-2):191-200.
2003: Lorenz Haegele; Barbara Ingold; Heike Naumann; Ghazaleh Tabatabai; Birgit Ledermann; Sebastian Brandner
Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression.
Molecular and cellular neurosciences 2003;24(3):696-708.
2003: Giovanna Mallucci; Andrew Dickinson; Jacqueline M Linehan; Peter-Christian Klöhn; Sebastian Brandner; John Collinge
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
Science (New York, N.Y.) 2003;302(5646):871-4.
2003: Silvia Marino; Dennis Hoogervoorst; Sebastian Brandner; Anton Berns
Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence.
Development (Cambridge, England) 2003;130(15):3359-68.
2003: Peter Wiesli; Michael Brändle; Sebastian Brandner; S S Kollias; René Bernays
Extensive spherical amyloid deposition presenting as a pituitary tumor.
Journal of endocrinological investigation 2003;26(6):552-5.
2003: Anthony R White; Perry Enever; MOURAD TAYEBI; Rosey Mushens; Jacqueline M Linehan; Sebastian Brandner; David J Anstee; John Collinge; Simon Hawke
Monoclonal antibodies inhibit prion replication and delay the development of prion disease.
Nature 2003;422(6927):80-3.
2003: John Collinge; Sebastian Brandner; Angus Kennedy; Martin N Rossor; Peter Smith; John Stevens; Peter Rudge
A 38-year-old man with a 9 month history of neurological and cognitive impairment.
Lancet neurology 2003;2(3):189-94.
2003: Andrea Capone Mori; M Hoeltzenbein; M Poetsch; J F Schneider; Sebastian Brandner; Eugen Boltshauser
Lhermitte-Duclos disease in 3 children: a clinical long-term observation.
Neuropediatrics 2003;34(1):30-5.
2003: Sebastian Brandner
CNS pathogenesis of prion diseases.
British medical bulletin 2003;66():131-9.
2002: Susan Joiner; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Irregular presence of abnormal prion protein in appendix in variant Creutzfeldt-Jakob disease.
Journal of neurology, neurosurgery, and psychiatry 2002;73(5):597-8.
2002: Hans H Jung; Sebastian Brandner
Malignant McLeod myopathy.
Muscle & nerve 2002;26(3):424-7.
2002: René Bernays; Spyros S Kollias; Nadia Khan; Sebastian Brandner; Sonja Meier; Yasuhiro Yonekawa
Histological yield, complications, and technological considerations in 114 consecutive frameless stereotactic biopsy procedures aided by open intraoperative magnetic resonance imaging.
Journal of neurosurgery 2002;97(2):354-62.
2002: Silvia Marino; Paul Krimpenfort; Carly Leung; Hetty van der Korput; Jan Trapman; Isabelle Camenisch; Anton Berns; Sebastian Brandner
PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.
Development (Cambridge, England) 2002;129(14):3513-22.
2002: Detlev Boison; Louis Scheurer; Valérie Zumsteg; Thomas Rülicke; Piotr Litynski; Brian Fowler; Sebastian Brandner; Hanns Mohler
Neonatal hepatic steatosis by disruption of the adenosine kinase gene.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6985-90.
2002: Markus Glatzel; Sebastian Brandner; Michael A Klein; Sonja Horstmann; Adriano Aguzzi
Prions--role of the peripheral nervous system.
Virus research 2002;82(1-2):53.
2001: Hans H Jung; D Russo; C Redman; Sebastian Brandner
Kell and XK immunohistochemistry in McLeod myopathy.
Muscle & nerve 2001;24(10):1346-51.
2001: Jun Masuoka; Sebastian Brandner; W Paulus; D Soffer; A Vital; Leila Chimelli; A Jouvet; Yasuhiro Yonekawa; Paul Kleihues; Hiroko Ohgaki
Germline SDHD mutation in paraganglioma of the spinal cord.
Oncogene 2001;20(36):5084-6.
2001: H Alkadhi; M Keller; Sebastian Brandner; Yasuhiro Yonekawa; Spyros S Kollias
Neuroimaging of cerebellar liponeurocytoma. Case report.
Journal of neurosurgery 2001;95(2):324-31.
2001: Axel Behrens; Sebastian Brandner; Nicolas Genoud; Adriano Aguzzi
Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel.
EMBO reports 2001;2(4):347-52.
2001: Rui M Reis; R Herva; Sebastian Brandner; J Koivukangas; N Mironov; W Bär; Paul Kleihues; Hiroko Ohgaki
Second primary glioblastoma.
Journal of neuropathology and experimental neurology 2001;60(2):208-15.
2001: Adriano Aguzzi; Sebastian Brandner; MB Fischer; Hisako Furukawa; Markus Glatzel; C Hawkins; Frank L Heppner; Fabio Montrasio; Beatriz Navarro; P Parizek; Vladimir Pekarik; Marco Prinz; Alex J Raeber; C Röckl; Michael A Klein
Spongiform encephalopathies: insights from transgenic models.
Advances in virus research 2001;56():313-52.
2000: Sebastian Brandner; Michael A Klein; Rico Frigg; Vladimir Pekarik; P Parizek; Alex J Raeber; Markus Glatzel; Petra Schwarz; Thomas Rülicke; Charles Weissmann; Adriano Aguzzi
Neuroinvasion of prions: insights from mouse models.
Experimental physiology 2000;85(6):705-12.
2000: Stephan Krähenbühl; Sebastian Brandner; S Kleinle; S Liechti; D Straumann
Mitochondrial diseases represent a risk factor for valproate-induced fulminant liver failure.
Liver 2000;20(4):346-8.
2000: Y Benninger; S Marino; R Hardegger; Charles Weissmann; Adriano Aguzzi; Sebastian Brandner
Differentiation and histological analysis of embryonic stem cell-derived neural transplants in mice.
Brain pathology (Zurich, Switzerland) 2000;10(3):330-41.
2000: T A Huisman; Sebastian Brandner; Felix K Niggli; D R Betts; E Boltshauser; E Martin
Malignant rhabdoid tumor of the brain: quantitative 1H MR-spectroscopy and cytogenetics.
Neuropediatrics 2000;31(3):159-61.
2000: P Zehnder; W Jenni; Sebastian Brandner; M Stäubli; W Waespe; A Aeschlimann
[Vasculitis and mononeuritis multiplex].
Praxis 2000;89(18):776-84.
2000: Sebastian Brandner; Michael A Klein; Adriano Aguzzi
[Mechanisms of neuroinvasion by prions: molecular principles and present state of research].
Schweizerische medizinische Wochenschrift 2000;130(12):435-42.
2000: P Kreis; Sebastian Brandner; Michael W H Coughtrie; Ulrike Pabel; Walter Meinl; Hansruedi Glatt; Ulrich Andrae
Human phenol sulfotransferases hP-PST and hM-PST activate propane 2-nitronate to a genotoxicant.
Carcinogenesis 2000;21(2):295-9.
2000: Markus Glatzel; Michael A Klein; Sebastian Brandner; Adriano Aguzzi
Prions: from neurografts to neuroinvasion.
Archives of virology. Supplementum 2000;(16):3-12.
2000: Adriano Aguzzi; Michael A Klein; Fabio Montrasio; Vladimir Pekarik; Sebastian Brandner; Hisako Furukawa; P Käser; C Röckl; Markus Glatzel
Prions: pathogenesis and reverse genetics.
Annals of the New York Academy of Sciences 2000;920():140-57.
2000: Thierry A G M Huisman; Sebastian Brandner; F Niggli; G Kacl; Ulrich V Willi; E Martin
Meningeal hemangiopericytoma in childhood.
European radiology 2000;10(7):1073-5.
2000: P Moosmann; Sebastian Brandner; S Kleinle; Beat Frauchiger
Hyperventilation due to mitochondrial myopathy.
Journal of the Royal Society of Medicine 2000;93(1):25-6.
1999: W Paulus; Sebastian Brandner
Synaptophysin in choroid plexus epithelial cells: no useful aid in differential diagnosis.
Journal of neuropathology and experimental neurology 1999;58(10):1111-2.
1999: Adriano Aguzzi; Sebastian Brandner
The genetics of prions--a contradiction in terms?
Lancet 1999;354 Suppl 1():SI22-5.
1999: Peter Lichtlen; Oleg Georgiev; Walter Schaffner; Adriano Aguzzi; Sebastian Brandner
The heavy metal-responsive transcription factor-1 (MTF-1) is not required for neural differentiation.
Biological chemistry 1999;380(6):711-5.
1999: A Aguzzi; Sebastian Brandner
Shrinking prions: new folds to old questions.
Nature medicine 1999;5(5):486-7.
1999: Alex J Raeber; A Sailer; Ivan Hegyi; Michael A Klein; Thomas Rülicke; Marc Fischer; Sebastian Brandner; Adriano Aguzzi; Charles Weissmann
Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3987-92.
1999: Sebastian Brandner; Michael A Klein; Adriano Aguzzi
A crucial role for B cells in neuroinvasive scrapie.
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 1999;6(1):17-23.
1998: Adriano Aguzzi; M G D'Angelo; Michael A Klein; Rico Frigg; MB Fischer; Alex J Raeber; C Röckl; Christine Huber-Musahl; Ivan Hegyi; Sebastian Brandner
[The new research frontier on prion disease].
Pathologica 1998;90(6):743-52.
1998: Alex J Raeber; Sebastian Brandner; Michael A Klein; Y Benninger; Christine Huber-Musahl; Rico Frigg; C Roeckl; MB Fischer; Charles Weissmann; Adriano Aguzzi
Transgenic and knockout mice in research on prion diseases.
Brain pathology (Zurich, Switzerland) 1998;8(4):715-33.
1998: S Kleinle; V Schneider; P Moosmann; Sebastian Brandner; Stephan Krähenbühl; S Liechti-Gallati
A novel mitochondrial tRNA(Phe) mutation inhibiting anticodon stem formation associated with a muscle disease.
Biochemical and biophysical research communications 1998;247(1):112-5.
1998: David H Shmerling; Ivan Hegyi; Marc Fischer; Thomas Blättler; Sebastian Brandner; Jürgen Götz; Thomas Rülicke; Eckhard Flechsig; Antonio Cozzio; C von Mering; C Hangartner; Adriano Aguzzi; Charles Weissmann
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.
Cell 1998;93(2):203-14.
1998: Charles Weissmann; Marc Fischer; Alex J Raeber; Hansruedi Büeler; A Sailer; David H Shmerling; Thomas Rülicke; Sebastian Brandner; Adriano Aguzzi
The use of transgenic mice in the investigation of transmissible spongiform encephalopathies.
Revue scientifique et technique (International Office of Epizootics) 1998;17(1):278-90.
1998: Ugo Rovigatti; T Afanasyeva; Sebastian Brandner; Johannes A Hainfellner; M Kiess; AS Maddalena; G Malin; Thomas Rülicke; J Steinbach; J Weissenberger; Adriano Aguzzi
Transgenic mice as research tools in neurocarcinogenesis.
Journal of neurovirology 1998;4(2):159-74.
1998: Adriano Aguzzi; Michael A Klein; Christine Huber-Musahl; Alex J Raeber; Thomas Blättler; Ivan Hegyi; Rico Frigg; Sebastian Brandner
Use of brain grafts to study the pathogenesis of prion diseases.
Essays in biochemistry 1998;33():133-47.
1998: Alex J Raeber; Michael A Klein; Rico Frigg; Sebastian Brandner; Thomas Blättler; Adriano Aguzzi
[Significance of prion protein in transmission of prions and in pathogenesis of spongiform encephalopathies].
Wiener medizinische Wochenschrift (1946) 1998;148(4):74-7.
1998: Sebastian Brandner; S Isenmann; G Kühne; Adriano Aguzzi
Identification of the end stage of scrapie using infected neural grafts.
Brain pathology (Zurich, Switzerland) 1998;8(1):19-27.
1997: Alex J Raeber; Richard E Race; Sebastian Brandner; Suzette A Priola; A Sailer; RA Bessen; Lennart Mucke; J Manson; Adriano Aguzzi; M B Oldstone; Charles Weissmann; Bruce Chesebro
Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.
The EMBO journal 1997;16(20):6057-65.
1997: Adriano Aguzzi; AS Maddalena; Sebastian Brandner; M Klein
[Molecular pathogenesis of spongiform encephalopathy].
Pathologica 1997;89(5):481-90.
1997: Thomas Blättler; Sebastian Brandner; Alex J Raeber; Michael A Klein; T Voigtländer; Charles Weissmann; Adriano Aguzzi
PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain.
Nature 1997;389(6646):69-73.
1997: Adriano Aguzzi; Thomas Blättler; Michael A Klein; A J Räber; Ivan Hegyi; Rico Frigg; Sebastian Brandner; Charles Weissmann
Tracking prions: the neurografting approach.
Cellular and molecular life sciences : CMLS 1997;53(6):485-95.
1997: Frank Duffner; Sebastian Brandner; H Opitz; R Klier; Ernst H Grote
Primary Candida albicans empyema associated with epidural hematomas in craniocervical junction.
Clinical neuropathology 1997;16(3):143-6.
1997: Adriano Aguzzi; Alex J Raeber; Thomas Blättler; Eckhard Flechsig; M Klein; Charles Weissmann; Sebastian Brandner
Neurotoxicity and neuroinvasiveness of prions.
Journal of neurovirology 1997;3 Suppl 1():S23-4.
1996: Charles Weissmann; Marc Fischer; Alex J Raeber; Hansruedi Büeler; A Sailer; David H Shmerling; Thomas Rülicke; Sebastian Brandner; Adriano Aguzzi
The use of transgenic mice in the investigation of transmissible spongiform encephalopathies.
International journal of experimental pathology 1996;77(6):283-93.
1996: Sebastian Brandner; Alex J Raeber; A Sailer; Thomas Blättler; Marc Fischer; Charles Weissmann; Adriano Aguzzi
Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13148-51.
1996: S Isenmann; Sebastian Brandner; Adriano Aguzzi
Neuroectodermal grafting: a new tool for the study of neurodegenerative diseases.
Histology and histopathology 1996;11(4):1063-73.
1996: S Isenmann; Sebastian Brandner; G Kühne; J Boner; Adriano Aguzzi
Comparative in vivo and pathological analysis of the blood-brain barrier in mouse telencephalic transplants.
Neuropathology and applied neurobiology 1996;22(2):118-28.
1996: S Isenmann; Sebastian Brandner; Ulrich Sure; Adriano Aguzzi
Telencephalic transplants in mice: characterization of growth and differentiation patterns.
Neuropathology and applied neurobiology 1996;22(2):108-17.
1996: Jean-Marc Fritschy; Sebastian Brandner; Adriano Aguzzi; M Koedood; Bernhard Luscher; P J Mitchell
Brain cell type specificity and gliosis-induced activation of the human cytomegalovirus immediate-early promoter in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(7):2275-82.
1996: Marc Fischer; Thomas Rülicke; Alex J Raeber; A Sailer; M Moser; Bruno Oesch; Sebastian Brandner; Adriano Aguzzi; Charles Weissmann
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.
The EMBO journal 1996;15(6):1255-64.
1996: Adriano Aguzzi; Sebastian Brandner; S Marino; Joachim P Steinbach
Transgenic and knockout mice in the study of neurodegenerative diseases.
Journal of molecular medicine (Berlin, Germany) 1996;74(3):111-26.
1996: R R Tschopp; Sebastian Brandner; S Marino; K Bothe; Ivan Horak; Axel Rethwilm; Adriano Aguzzi
Analysis of the determinants of neurotropism and neurotoxicity of HFV in transgenic mice.
Virology 1996;216(2):338-46.
1996: RL Lindberg; C Porcher; B Grandchamp; Birgit Ledermann; K Bürki; Sebastian Brandner; A Aguzzi; Urs A Meyer
Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria.
Nature genetics 1996;12(2):195-9.
1996: Sebastian Brandner; S Isenmann; Alex J Raeber; Marc Fischer; A Sailer; Y Kobayashi; S Marino; Charles Weissmann; Adriano Aguzzi
Normal host prion protein necessary for scrapie-induced neurotoxicity.
Nature 1996;379(6563):339-43.
1996: U Müller; N Cristina; Z W Li; David P Wolfer; Hans-Peter Lipp; Thomas Rülicke; Sebastian Brandner; Adriano Aguzzi; C Weissman
Mice homozygous for a modified beta-amyloid precursor protein (beta APP) gene show impaired behavior and high incidence of agenesis of the corpus callosum.
Annals of the New York Academy of Sciences 1996;777():65-73.
1996: Charles Weissmann; Marc Fischer; Alex J Raeber; Hansruedi Büeler; A Sailer; David H Shmerling; Thomas Rülicke; Sebastian Brandner; Adriano Aguzzi
The role of PrP in pathogenesis of experimental scrapie.
Cold Spring Harbor symposia on quantitative biology 1996;61():511-22.
1996: W Hassler; Sebastian Brandner; I Slansky
Microsurgical management of lateral lumbar disc herniations: combined lateral and interlaminar approach.
Acta neurochirurgica 1996;138(8):907-10; discussion 910-1.
1995: S Isenmann; M Molthagen; Sebastian Brandner; Udo Bartsch; G Kühne; Josef Magyar; Ulrich Sure; Melitta Schachner; Adriano Aguzzi
The AMOG/beta 2 subunit of Na,K-ATPase is not necessary for long-term survival of telencephalic grafts.
Glia 1995;15(4):377-88.
1995: Adriano Aguzzi; Sebastian Brandner; S Isenmann; Joachim P Steinbach; Ulrich Sure
Transgenic and gene disruption techniques in the study of neurocarcinogenesis.
Glia 1995;15(3):348-64.
1995: K N Strommer; Sebastian Brandner; A C Sarioglu; Ulrich Sure; Yasuhiro Yonekawa
Symptomatic cerebellar metastasis and late local recurrence of a cauda equina paraganglioma. Case report.
Journal of neurosurgery 1995;83(1):166-9.
1995: S Marino; C Kretschmer; Sebastian Brandner; C Cavard; A Zider; Pascale Briand; S Isenmann; E F Wagner; Adriano Aguzzi
Activation of HIV transcription by human foamy virus in transgenic mice.
Laboratory investigation; a journal of technical methods and pathology 1995;73(1):103-10.
1995: Ulrich Sure; Helmut Bertalanffy; S Isenmann; Sebastian Brandner; W J Berghorn; Werner Seeger; Adriano Aguzzi
Secondary manifestation of medulloblastoma: metastases and local recurrences in 66 patients.
Acta neurochirurgica 1995;136(3-4):117-26.
1995: J A Kraus; J Koopmann; P Kaskel; D Maintz; Sebastian Brandner; Johannes Schramm; David N Louis; Otmar D Wiestler; Andreas von Deimling
Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma.
Journal of neuropathology and experimental neurology 1995;54(1):91-5.
1994: U Müller; N Cristina; Z W Li; David P Wolfer; Hans-Peter Lipp; Thomas Rülicke; Sebastian Brandner; Adriano Aguzzi; Charles Weissmann
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene.
Cell 1994;79(5):755-65.
1994: S Marino; Sebastian Brandner
Molecular analysis of development and neoplasia: homologous recombination and knock-out approaches, Schloss Reisenburg, Germany, March 22nd, 1994.
Brain pathology (Zurich, Switzerland) 1994;4(3):285-6.
1994: S Albrecht; A von Deimling; T Pietsch; F Giangaspero; Sebastian Brandner; P Kleihues; O D Wiestler
Microsatellite analysis of loss of heterozygosity on chromosomes 9q, 11p and 17p in medulloblastomas.
Neuropathology and applied neurobiology 1994;20(1):74-81.
1994: Adriano Aguzzi; Sebastian Brandner; Ulrich Sure; D Rüedi; S Isenmann
Transgenic and knock-out mice: models of neurological disease.
Brain pathology (Zurich, Switzerland) 1994;4(1):3-20.
1994: S Isenmann; Sebastian Brandner; Ulrich Sure; Josef Magyar; Melitta Schachner; Adriano Aguzzi
[Morphology and development of neural transplants of AMOG-deficient mice].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1994;78():433-7.
1990: Sebastian Brandner; H Redies
The projection from medial geniculate to field AI in cat: organization in the isofrequency dimension.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(1):50-61.
1989: H Redies; Sebastian Brandner; O D Creutzfeldt
Anatomy of the auditory thalamocortical system of the guinea pig.
The Journal of comparative neurology 1989;282(4):489-511.