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Stephen Buchwald

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TOP 3
Mao Chen; Stephen L Buchwald
Continuous-flow synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines in a C-N bond formation/hydrogenation/diazotization/cyclization sequence.
Xiao Wang; Stephen L Buchwald
Synthesis of optically pure 2-trifluoromethyl lactic acid by asymmetric hydroformylation.
Andrew DeAngelis; Dong-Hui Wang; Stephen L Buchwald
Mild and rapid Pd-catalyzed cross-coupling with hydrazine in continuous flow: application to the synthesis of functionalized heterocycles.

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All Publications

2013: Mao Chen; Stephen L Buchwald
Continuous-flow synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines in a C-N bond formation/hydrogenation/diazotization/cyclization sequence.
Angewandte Chemie (International ed. in English) 2013;52(15):4247-50.
2013: Xiao Wang; Stephen L Buchwald
Synthesis of optically pure 2-trifluoromethyl lactic acid by asymmetric hydroformylation.
The Journal of organic chemistry 2013;78(7):3429-33.
2013: Andrew DeAngelis; Dong-Hui Wang; Stephen L Buchwald
Mild and rapid Pd-catalyzed cross-coupling with hydrazine in continuous flow: application to the synthesis of functionalized heterocycles.
Angewandte Chemie (International ed. in English) 2013;52(12):3434-7.
2013: Ekaterina V Vinogradova; Brett P Fors; Nathaniel H Park; Stephen L Buchwald
Palladium-catalyzed synthesis of N-aryl carbamates.
Organic letters 2013;15(6):1394-7.
2013: Yang Yang; Nathan J Oldenhuis; Stephen L Buchwald
Mild and general conditions for negishi cross-coupling enabled by the use of palladacycle precatalysts.
Angewandte Chemie (International ed. in English) 2013;52(2):615-9.
2012: Phillip J Milner; Peter Müller; Mingjuan Su; Jiahao Chen; Thomas J Maimone; Stephen L Buchwald
Investigating the dearomative rearrangement of biaryl phosphine-ligated Pd(II) complexes.
Journal of the American Chemical Society 2012;134(48):19922-34.
2012: Satoshi Ueda; Stephen L Buchwald
Catalyst-controlled chemoselective arylation of 2-aminobenzimidazoles.
Angewandte Chemie (International ed. in English) 2012;51(41):10364-7.
2012: Matthias A Oberli; Stephen L Buchwald
A general method for Suzuki-Miyaura coupling reactions using lithium triisopropyl borates.
Organic letters 2012;14(17):4606-9.
2012: Chi Wai Cheung; Stephen L Buchwald
Room temperature copper(II)-catalyzed oxidative cyclization of enamides to 2,5-disubstituted oxazoles via vinylic C-H functionalization.
The Journal of organic chemistry 2012;77(17):7526-37.
2012: Natalia Chernyak; Stephen L Buchwald
Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts.
Journal of the American Chemical Society 2012;134(30):12466-9.
2012: Rong Zhu; Stephen L Buchwald
Copper-catalyzed oxytrifluoromethylation of unactivated alkenes.
Journal of the American Chemical Society 2012;134(30):12462-5.
2012: Ekaterina V Vinogradova; Brett P Fors; Stephen L Buchwald
Palladium-catalyzed cross-coupling of aryl chlorides and triflates with sodium cyanate: a practical synthesis of unsymmetrical ureas.
Journal of the American Chemical Society 2012;134(27):11132-5.
2012: Wei Shu; Stephen L Buchwald
Enantioselective β-arylation of ketones enabled by lithiation/borylation/1,4-addition sequence under flow conditions.
Angewandte Chemie (International ed. in English) 2012;51(22):5355-8.
2012: Mingjuan Su; Stephen L Buchwald
A bulky biaryl phosphine ligand allows for palladium-catalyzed amidation of five-membered heterocycles as electrophiles.
Angewandte Chemie (International ed. in English) 2012;51(19):4710-3.
2012: Andrew T Parsons; Todd D Senecal; Stephen L Buchwald
Iron(II)-catalyzed trifluoromethylation of potassium vinyltrifluoroborates.
Angewandte Chemie (International ed. in English) 2012;51(12):2947-50.
2012: Meredeth A McGowan; Jaclyn L Henderson; Stephen L Buchwald
Palladium-catalyzed N-arylation of 2-aminothiazoles.
Organic letters 2012;14(6):1432-5.
2012: Satoshi Ueda; Brett P Fors; Siraj Ali; Stephen L Buchwald
Me3(OMe)tBuXPhos: a surrogate ligand for Me4tBuXPhos in palladium-catalyzed C-N and C-O bond-forming reactions.
The Journal of organic chemistry 2012;77(5):2543-7.
2012: Rong Zhu; Stephen L Buchwald
Combined oxypalladation/C-H functionalization: palladium(II)-catalyzed intramolecular oxidative oxyarylation of hydroxyalkenes.
Angewandte Chemie (International ed. in English) 2012;51(8):1926-9.
2011: Xiao Wang; Stephen L Buchwald
Rh-catalyzed asymmetric hydroformylation of functionalized 1,1-disubstituted olefins.
Journal of the American Chemical Society 2011;133(47):19080-3.
2011: Thomas J Maimone; Phillip J Milner; Michael K Takase; Yong Zhang; Tom Kinzel; Stephen L Buchwald
Evidence for in situ catalyst modification during the Pd-catalyzed conversion of aryl triflates to aryl fluorides.
Journal of the American Chemical Society 2011;133(45):18106-9.
2011: Wei Shu; Matthias A Oberli; Laurent Pellegatti; Stephen L Buchwald
Continuous-flow synthesis of biaryls enabled by multistep solid-handling in a lithiation/borylation/Suzuki-Miyaura cross-coupling sequence.
Angewandte Chemie (International ed. in English) 2011;50(45):10665-9.
2011: Xiaoxing Wu; Brett P Fors; Stephen L Buchwald
A single phosphine ligand allows palladium-catalyzed intermolecular C-O bond formation with secondary and primary alcohols.
Angewandte Chemie (International ed. in English) 2011;50(42):9943-7.
2011: Timothy Noël; Stephen L Buchwald
Cross-coupling in flow.
Chemical Society reviews 2011;40(10):5010-29.
2011: Andrew T Parsons; Stephen L Buchwald
Copper-catalyzed trifluoromethylation of unactivated olefins.
Angewandte Chemie (International ed. in English) 2011;50(39):9120-3.
2011: Jun Pan; Xinyan Wang; Yong Zhang; Stephen L Buchwald
An improved palladium-catalyzed conversion of aryl and vinyl triflates to bromides and chlorides.
Organic letters 2011;13(18):4974-6.
2011: Dmitry Tsvelikhovsky; Stephen L Buchwald
Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues.
Journal of the American Chemical Society 2011;133(36):14228-31.
2011: Satoshi Ueda; Mingjuan Su; Stephen L Buchwald
Highly N2-selective palladium-catalyzed arylation of 1,2,3-triazoles.
Angewandte Chemie (International ed. in English) 2011;50(38):8944-7.
2011: Timothy Noël; Thomas J Maimone; Stephen L Buchwald
Accelerating palladium-catalyzed C-F bond formation: use of a microflow packed-bed reactor.
Angewandte Chemie (International ed. in English) 2011;50(38):8900-3.
2011: Jun Pan; Mingjuan Su; Stephen L Buchwald
Palladium(0)-catalyzed intermolecular amination of unactivated C(sp³)-H bonds.
Angewandte Chemie (International ed. in English) 2011;50(37):8647-51.
2011: Georgiy Teverovskiy; David S Surry; Stephen L Buchwald
Pd-catalyzed synthesis of Ar-SCF3 compounds under mild conditions.
Angewandte Chemie (International ed. in English) 2011;50(32):7312-4.
2011: Pengfei Li; Stephen L Buchwald
Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed α-arylation/alkylation sequence.
Angewandte Chemie (International ed. in English) 2011;50(28):6396-400.
2011: Sophie Rousseaux; Miguel Angel Del Aguila Sanchez; Jorge García-Fortanet; Stephen L Buchwald
Palladium(0)-catalyzed arylative dearomatization of phenols.
Journal of the American Chemical Society 2011;133(24):9282-5.
2011: Timothy Noël; Klavs F Jensen; Simon Kuhn; Andrew J Musacchio; Stephen L Buchwald
Suzuki-Miyaura cross-coupling reactions in flow: multistep synthesis enabled by a microfluidic extraction.
Angewandte Chemie (International ed. in English) 2011;50(26):5943-6.
2011: Simon Breitler; Brett P Fors; Nathan J Oldenhuis; Stephen L Buchwald
Synthesis of unsymmetrical diarylureas via Pd-catalyzed C-N cross-coupling reactions.
Organic letters 2011;13(12):3262-5.
2011: Todd D Senecal; Andrew T Parsons; Stephen L Buchwald
Room temperature aryl trifluoromethylation via copper-mediated oxidative cross-coupling.
The Journal of organic chemistry 2011;76(4):1174-6.
2010: John R Naber; Stephen L Buchwald
Packed-bed reactors for continuous-flow C-N cross-coupling.
Angewandte Chemie (International ed. in English) 2010;49(49):9469-74.
2010: Brett P Fors; Stephen L Buchwald
A multiligand based Pd catalyst for C-N cross-coupling reactions.
Journal of the American Chemical Society 2010;132(45):15914-7.
2010: Jaclyn L Henderson; Stephen L Buchwald
Efficient Pd-catalyzed amination reactions for heterocycle functionalization.
Organic letters 2010;12(20):4442-5.
2010: Jaclyn L Henderson; Sarah M McDermott; Stephen L Buchwald
Palladium-catalyzed amination of unprotected halo-7-azaindoles.
Organic letters 2010;12(20):4438-41.
2010: Dmitry Tsvelikhovsky; Stephen L Buchwald
Synthesis of heterocycles via Pd-ligand controlled cyclization of 2-chloro-N-(2-vinyl)aniline: preparation of carbazoles, indoles, dibenzazepines, and acridines.
Journal of the American Chemical Society 2010;132(40):14048-51.
2010: Tom Kinzel; Yong Zhang; Stephen L Buchwald
A new palladium precatalyst allows for the fast Suzuki-Miyaura coupling reactions of unstable polyfluorophenyl and 2-heteroaryl boronic acids.
Journal of the American Chemical Society 2010;132(40):14073-5.
2010: Xiaoqiang Shen; Alan M Hyde; Stephen L Buchwald
Palladium-catalyzed conversion of aryl and vinyl triflates to bromides and chlorides.
Journal of the American Chemical Society 2010;132(40):14076-8.
2010: Jonathan P McMullen; Matthew T Stone; Stephen L Buchwald; Klavs F Jensen
An integrated microreactor system for self-optimization of a Heck reaction: from micro- to mesoscale flow systems.
Angewandte Chemie (International ed. in English) 2010;49(39):7076-80.
2010: Xiaoqiang Shen; Gavin O Jones; Donald A Watson; Brijesh Bhayana; Stephen L Buchwald
Enantioselective synthesis of axially chiral biaryls by the Pd-catalyzed Suzuki-Miyaura reaction: substrate scope and quantum mechanical investigations.
Journal of the American Chemical Society 2010;132(32):11278-87.
2010: Thomas J Maimone; Stephen L Buchwald
Pd-catalyzed O-arylation of ethyl acetohydroximate: synthesis of O-arylhydroxylamines and substituted benzofurans.
Journal of the American Chemical Society 2010;132(29):9990-1.
2010: Eun Jin Cho; Todd D Senecal; Tom Kinzel; Yong Zhang; Donald A Watson; Stephen L Buchwald
The palladium-catalyzed trifluoromethylation of aryl chlorides.
Science (New York, N.Y.) 2010;328(5986):1679-81.
2010: Karin Dooleweerdt; Brett P Fors; Stephen L Buchwald
Pd-catalyzed cross-coupling reactions of amides and aryl mesylates.
Organic letters 2010;12(10):2350-3.
2010: Gavin O Jones; Peng Liu; Kendall N Houk; Stephen L Buchwald
Computational explorations of mechanisms and ligand-directed selectivities of copper-catalyzed Ullmann-type reactions.
Journal of the American Chemical Society 2010;132(17):6205-13.
2010: Debabrata Maiti; Stephen L Buchwald
Cu-catalyzed arylation of phenols: synthesis of sterically hindered and heteroaryl diaryl ethers.
The Journal of organic chemistry 2010;75(5):1791-4.
2010: Ryan L Hartman; John R Naber; Stephen L Buchwald; Klavs F Jensen
Multistep microchemical synthesis enabled by microfluidic distillation.
Angewandte Chemie (International ed. in English) 2010;49(5):899-903.
2010: Xiaoqiang Shen; Stephen L Buchwald
Rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated alkenes.
Angewandte Chemie (International ed. in English) 2010;49(3):564-7.
2009: Debabrata Maiti; Stephen L Buchwald
Orthogonal Cu- and Pd-based catalyst systems for the O- and N-arylation of aminophenols.
Journal of the American Chemical Society 2009;131(47):17423-9.
2009: Jacqueline D Hicks; Alan M Hyde; Alberto Martinez Cuezva; Stephen L Buchwald
Pd-catalyzed N-arylation of secondary acyclic amides: catalyst development, scope, and computational study.
Journal of the American Chemical Society 2009;131(46):16720-34.
2009: Donald A Watson; Mingjuan Su; Georgiy Teverovskiy; Yong Zhang; Jorge García-Fortanet; Tom Kinzel; Stephen L Buchwald
Formation of ArF from LPdAr(F): catalytic conversion of aryl triflates to aryl fluorides.
Science (New York, N.Y.) 2009;325(5948):1661-4.
2009: Brett P Fors; Stephen L Buchwald
Pd-catalyzed conversion of aryl chlorides, triflates, and nonaflates to nitroaromatics.
Journal of the American Chemical Society 2009;131(36):12898-9.
2009: Brijesh Bhayana; Brett P Fors; Stephen L Buchwald
A versatile catalyst system for Suzuki-Miyaura cross-coupling reactions of C(sp(2))-tosylates and mesylates.
Organic letters 2009;11(17):3954-7.
2009: Alexander M Taylor; Ryan Alan Altman; Stephen L Buchwald
Palladium-catalyzed enantioselective alpha-arylation and alpha-vinylation of oxindoles facilitated by an axially chiral P-stereogenic ligand.
Journal of the American Chemical Society 2009;131(29):9900-1.
2009: Alan M Hyde; Stephen L Buchwald
Synthesis of 5,5-disubstituted butenolides based on a Pd-catalyzed gamma-arylation strategy.
Organic letters 2009;11(12):2663-6.
2009: Chong Han; Stephen L Buchwald
Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides.
Journal of the American Chemical Society 2009;131(22):7532-3.
2009: Jorge García-Fortanet; Florian Kessler; Stephen L Buchwald
Palladium-catalyzed asymmetric dearomatization of naphthalene derivatives.
Journal of the American Chemical Society 2009;131(19):6676-7.
2009: Brett P Fors; Nicole R Davis; Stephen L Buchwald
An efficient process for pd-catalyzed C-N cross-coupling reactions of aryl iodides: insight into controlling factors.
Journal of the American Chemical Society 2009;131(16):5766-8.
2009: Mark R Biscoe; Stephen L Buchwald
Selective monoarylation of acetate esters and aryl methyl ketones using aryl chlorides.
Organic letters 2009;11(8):1773-5.
2009: Eric R. Strieter; Brijesh Bhayana; Stephen L Buchwald
Mechanistic studies on the copper-catalyzed N-arylation of amides.
Journal of the American Chemical Society 2009;131(1):78-88.
2008: Stephen L Buchwald
Cross coupling.
Accounts of chemical research 2008;41(11):1439.
2008: Ruben Martin; Stephen L Buchwald
Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions employing dialkylbiaryl phosphine ligands.
Accounts of chemical research 2008;41(11):1461-73.
2008: Brett P Fors; Donald A Watson; Mark R Biscoe; Stephen L Buchwald
A highly active catalyst for Pd-catalyzed amination reactions: cross-coupling reactions using aryl mesylates and the highly selective monoarylation of primary amines using aryl chlorides.
Journal of the American Chemical Society 2008;130(41):13552-4.
2008: W C Peter Tsang; Rachel H Munday; Gordon Brasche; Nan Zheng; Stephen L Buchwald
Palladium-catalyzed method for the synthesis of carbazoles via tandem C-H functionalization and C-N bond formation.
The Journal of organic chemistry 2008;73(19):7603-10.
2008: Donald A Watson; Xuexiang Fan; Stephen L Buchwald
Carbonylation of aryl chlorides with oxygen nucleophiles at atmospheric pressure. Preparation of phenyl esters as acyl transfer agents and the direct preparation of alkyl esters and carboxylic acids.
The Journal of organic chemistry 2008;73(18):7096-101.
2008: Joseph R Martinelli; Donald A Watson; Dominique M M Freckmann; Timothy E Barder; Stephen L Buchwald
Palladium-catalyzed carbonylation reactions of aryl bromides at atmospheric pressure: a general system based on Xantphos.
The Journal of organic chemistry 2008;73(18):7102-7.
2008: Ryan Alan Altman; Alan M Hyde; Xiaohua Huang; Stephen L Buchwald
Orthogonal Pd- and Cu-based catalyst systems for C- and N-arylation of oxindoles.
Journal of the American Chemical Society 2008;130(29):9613-20.
2008: Mark R Biscoe; Brett P Fors; Stephen L Buchwald
A new class of easily activated palladium precatalysts for facile C-N cross-coupling reactions and the low temperature oxidative addition of aryl chlorides.
Journal of the American Chemical Society 2008;130(21):6686-7.
2008: Rachel H Munday; Joseph R Martinelli; Stephen L Buchwald
Palladium-catalyzed carbonylation of aryl tosylates and mesylates.
Journal of the American Chemical Society 2008;130(9):2754-5.
2008: Ryan Alan Altman; Alexandr Shafir; Alice Choi; Phillip A Lichtor; Stephen L Buchwald
An improved Cu-based catalyst system for the reactions of alcohols with aryl halides.
The Journal of organic chemistry 2008;73(1):284-6.
2008: Jorge García-Fortanet; Stephen L Buchwald
Asymmetric palladium-catalyzed intramolecular alpha-arylation of aldehydes.
Angewandte Chemie (International ed. in English) 2008;47(42):8108-11.
2008: David S Surry; Stephen L Buchwald
Biaryl phosphane ligands in palladium-catalyzed amination.
Angewandte Chemie (International ed. in English) 2008;47(34):6338-61.
2008: Kelvin L Billingsley; Stephen L Buchwald
A general and efficient method for the Suzuki-Miyaura coupling of 2-pyridyl nucleophiles.
Angewandte Chemie (International ed. in English) 2008;47(25):4695-8.
2008: Gordon Brasche; Stephen L Buchwald
C-H functionalization/C-N bond formation: copper-catalyzed synthesis of benzimidazoles from amidines.
Angewandte Chemie (International ed. in English) 2008;47(10):1932-4.
2008: Alan M Hyde; Stephen L Buchwald
Palladium-catalyzed gamma-arylation of beta,gamma-unsaturated ketones: application to a one-pot synthesis of tricyclic indolines.
Angewandte Chemie (International ed. in English) 2008;47(1):177-80.
2007: Rubén Martín; Ana Cuenca; Stephen L Buchwald
Sequential copper-catalyzed vinylation/cyclization: an efficient synthesis of functionalized oxazoles.
Organic letters 2007;9(26):5521-4.
2007: Ana Minatti; Xiaolai Zheng; Stephen L Buchwald
Synthesis of chiral 3-substituted indanones via an enantioselective reductive-Heck reaction.
The Journal of organic chemistry 2007;72(24):9253-8.
2007: Nan Zheng; Stephen L Buchwald
Copper-catalyzed regiospecific synthesis of N-alkylbenzimidazoles.
Organic letters 2007;9(23):4749-51.
2007: Takashi Ikawa; Timothy E Barder; Mark R Biscoe; Stephen L Buchwald
Pd-catalyzed amidation of aryl chlorides using monodentate biaryl phosphine ligands: a kinetic, computational, and synthetic investigation.
Journal of the American Chemical Society 2007;129(43):13001-7.
2007: Carrie P Jones; Kevin Anderson; Stephen L Buchwald
Sequential Cu-catalyzed amidation-base-mediated camps cyclization: a two-step synthesis of 2-Aryl-4-quinolones from o-halophenones.
The Journal of organic chemistry 2007;72(21):7968-73.
2007: Timothy E Barder; Stephen L Buchwald
Insights into amine binding to biaryl phosphine palladium oxidative addition complexes and reductive elimination from biaryl phosphine arylpalladium amido complexes via density functional theory.
Journal of the American Chemical Society 2007;129(39):12003-10.
2007: Eric McNeill; Timothy E Barder; Stephen L Buchwald
Palladium-catalyzed silylation of aryl chlorides with hexamethyldisilane.
Organic letters 2007;9(19):3785-8.
2007: David S Surry; Stephen L Buchwald
Selective palladium-catalyzed arylation of ammonia: synthesis of anilines as well as symmetrical and unsymmetrical di- and triarylamines.
Journal of the American Chemical Society 2007;129(34):10354-5.
2007: Rubén Martín; Catharine H Larsen; Ana Cuenca; Stephen L Buchwald
Cu-catalyzed tandem C-N bond formation for the synthesis of pyrroles and heteroarylpyrroles.
Organic letters 2007;9(17):3379-82.
2007: Ryan Alan Altman; Erica D Koval; Stephen L Buchwald
Copper-catalyzed N-arylation of imidazoles and benzimidazoles.
The Journal of organic chemistry 2007;72(16):6190-9.
2007: Timothy E Barder; Stephen L Buchwald
Rationale behind the resistance of dialkylbiaryl phosphines toward oxidation by molecular oxygen.
Journal of the American Chemical Society 2007;129(16):5096-101.
2007: Ruben Martin; Stephen L Buchwald
Pd-catalyzed Kumada-Corriu cross-coupling reactions at low temperatures allow the use of Knochel-type Grignard reagents.
Journal of the American Chemical Society 2007;129(13):3844-5.
2007: Alexandr Shafir; Phillip A Lichtor; Stephen L Buchwald
N- versus O-arylation of aminoalcohols: orthogonal selectivity in copper-based catalysts.
Journal of the American Chemical Society 2007;129(12):3490-1.
2007: Kelvin L Billingsley; Stephen L Buchwald
Highly efficient monophosphine-based catalyst for the palladium-catalyzed suzuki-miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
Journal of the American Chemical Society 2007;129(11):3358-66.
2007: Marta Rodríguez Rivero; Stephen L Buchwald
Copper-catalyzed vinylation of hydrazides. A regioselective entry to highly substituted pyrroles.
Organic letters 2007;9(6):973-6.
2007: Ryan Alan Altman; Stephen L Buchwald
Cu-catalyzed N- and O-arylation of 2-, 3-, and 4-hydroxypyridines and hydroxyquinolines.
Organic letters 2007;9(4):643-6.
2007: Timothy E Barder; Stephen L Buchwald
Benchtop monitoring of reaction progress via visual recognition with a handheld UV lamp: in situ monitoring of boronic acids in the Suzuki-Miyaura reaction.
Organic letters 2007;9(1):137-9.
2007: Ryan Alan Altman; Stephen L Buchwald
Pd-catalyzed Suzuki-Miyaura reactions of aryl halides using bulky biarylmonophosphine ligands.
Nature protocols 2007;2(12):3115-21.
2007: Ryan Alan Altman; Brett P Fors; Stephen L Buchwald
Pd-catalyzed amination reactions of aryl halides using bulky biarylmonophosphine ligands.
Nature protocols 2007;2(11):2881-7.
2007: Ryan Alan Altman; Stephen L Buchwald
Cu-catalyzed Goldberg and Ullmann reactions of aryl halides using chelating N- and O-based ligands.
Nature protocols 2007;2(10):2474-9.
2007: Joseph R Martinelli; Thomas P Clark; Donald A Watson; Rachel H Munday; Stephen L Buchwald
Palladium-catalyzed aminocarbonylation of aryl chlorides at atmospheric pressure: the dual role of sodium phenoxide.
Angewandte Chemie (International ed. in English) 2007;46(44):8460-3.
2007: Rubén Martín; Stephen L Buchwald
A general method for the direct alpha-arylation of aldehydes with aryl bromides and chlorides.
Angewandte Chemie (International ed. in English) 2007;46(38):7236-9.
2007: Nan Zheng; Kevin Anderson; Xiaohua Huang; Hanh Nho Nguyen; Stephen L Buchwald
A palladium-catalyzed regiospecific synthesis of N-aryl benzimidazoles.
Angewandte Chemie (International ed. in English) 2007;46(39):7509-12.
2007: Mark R Biscoe; Timothy E Barder; Stephen L Buchwald
Electronic effects on the selectivity of pd-catalyzed C-N bond-forming reactions using biarylphosphine ligands: the competitive roles of amine binding and acidity.
Angewandte Chemie (International ed. in English) 2007;46(38):7232-5.
2007: Kelvin L Billingsley; Timothy E Barder; Stephen L Buchwald
Palladium-catalyzed borylation of aryl chlorides: scope, applications, and computational studies.
Angewandte Chemie (International ed. in English) 2007;46(28):5359-63.
2007: Edward R Murphy; Joseph R Martinelli; Nikolay Zaborenko; Stephen L Buchwald; Klavs F Jensen
Accelerating reactions with microreactors at elevated temperatures and pressures: profiling aminocarbonylation reactions.
Angewandte Chemie (International ed. in English) 2007;46(10):1734-7.
2006: Rubén Martín; Marta Rodríguez Rivero; Stephen L Buchwald
Domino cu-catalyzed C--N coupling/hydroamidation: a highly efficient synthesis of nitrogen heterocycles.
Angewandte Chemie (International ed. in English) 2006;45(42):7079-82.
2006: Joseph R Martinelli; Dominique M M Freckmann; Stephen L Buchwald
Convenient method for the preparation of Weinreb amides via Pd-catalyzed aminocarbonylation of aryl bromides at atmospheric pressure.
Organic letters 2006;8(21):4843-6.
2006: Kevin Anderson; Rachel E Tundel; Takashi Ikawa; Ryan Alan Altman; Stephen L Buchwald
Monodentate phosphines provide highly active catalysts for Pd-catalyzed C-N bond-forming reactions of heteroaromatic halides/amines and (H)N-heterocycles.
Angewandte Chemie (International ed. in English) 2006;45(39):6523-7.
2006: Kevin Anderson; Takashi Ikawa; Rachel E Tundel; Stephen L Buchwald
The selective reaction of aryl halides with KOH: synthesis of phenols, aromatic ethers, and benzofurans.
Journal of the American Chemical Society 2006;128(33):10694-5.
2006: Alexandr Shafir; Stephen L Buchwald
Highly selective room-temperature copper-catalyzed C-N coupling reactions.
Journal of the American Chemical Society 2006;128(27):8742-3.
2006: Carlos H Burgos; Timothy E Barder; Xiaohua Huang; Stephen L Buchwald
Significantly improved method for the pd-catalyzed coupling of phenols with aryl halides: understanding ligand effects.
Angewandte Chemie (International ed. in English) 2006;45(26):4321-6.
2006: Ryan Alan Altman; Stephen L Buchwald
4,7-Dimethoxy-1,10-phenanthroline: an excellent ligand for the Cu-catalyzed N-arylation of imidazoles.
Organic letters 2006;8(13):2779-82.
2006: Kelvin L Billingsley; Kevin Anderson; Stephen L Buchwald
A highly active catalyst for Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds.
Angewandte Chemie (International ed. in English) 2006;45(21):3484-8.
2006: Shashank Shekhar; Per Ryberg; John F Hartwig; Jinu S Mathew; Donna G Blackmond; Eric R. Strieter; Stephen L Buchwald
Reevaluation of the mechanism of the amination of aryl halides catalyzed by BINAP-ligated palladium complexes.
Journal of the American Chemical Society 2006;128(11):3584-91.
2006: Eric R. Strieter; Stephen L Buchwald
Evidence for the formation and structure of palladacycles during Pd-catalyzed C-N bond formation with catalysts derived from bulky monophosphinobiaryl ligands.
Angewandte Chemie (International ed. in English) 2006;45(6):925-8.
2006: Rachel E Tundel; Kevin Anderson; Stephen L Buchwald
Expedited palladium-catalyzed amination of aryl nonaflates through the use of microwave-irradiation and soluble organic amine bases.
The Journal of organic chemistry 2006;71(1):430-3.
2005: W C Peter Tsang; Nan Zheng; Stephen L Buchwald
Combined C-H functionalization/C-N bond formation route to carbazoles.
Journal of the American Chemical Society 2005;127(42):14560-1.
2005: Matthew P Rainka; Jacqueline E Milne; Stephen L Buchwald
Dynamic kinetic resolution of alpha,beta-unsaturated lactones through asymmetric copper-catalyzed conjugate reduction: application to the total synthesis of eupomatilone-3.
Angewandte Chemie (International ed. in English) 2005;44(38):6177-80.
2005: Kevin Anderson; Stephen L Buchwald
General catalysts for the Suzuki-Miyaura and Sonogashira coupling reactions of aryl chlorides and for the coupling of challenging substrate combinations in water.
Angewandte Chemie (International ed. in English) 2005;44(38):6173-7.
2005: Edward J Hennessy; Stephen L Buchwald
Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination.
The Journal of organic chemistry 2005;70(18):7371-5.
2005: Mark D Charles; Phillip Schultz; Stephen L Buchwald
Efficient pd-catalyzed amination of heteroaryl halides.
Organic letters 2005;7(18):3965-8.
2005: Andrei V Vorogushin; Xiaohua Huang; Stephen L Buchwald
Use of tunable ligands allows for intermolecular Pd-catalyzed C--O bond formation.
Journal of the American Chemical Society 2005;127(22):8146-9.
2005: Timothy E Barder; Shawn D Walker; Joseph R Martinelli; Stephen L Buchwald
Catalysts for Suzuki-Miyaura coupling processes: scope and studies of the effect of ligand structure.
Journal of the American Chemical Society 2005;127(13):4685-96.
2005: Eric R. Strieter; Donna G Blackmond; Stephen L Buchwald
The role of chelating diamine ligands in the goldberg reaction: a kinetic study on the copper-catalyzed amidation of aryl iodides.
Journal of the American Chemical Society 2005;127(12):4120-1.
2004: Junghyun Chae; Jaesook Yun; Stephen L Buchwald
One-pot sequential Cu-catalyzed reduction and Pd-catalyzed arylation of silyl enol ethers.
Organic letters 2004;6(26):4809-12.
2004: Jacqueline E Milne; Stephen L Buchwald
An extremely active catalyst for the Negishi cross-coupling reaction.
Journal of the American Chemical Society 2004;126(40):13028-32.
2004: Jon C Antilla; Jeremy M Baskin; Timothy E Barder; Stephen L Buchwald
Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles.
The Journal of organic chemistry 2004;69(17):5578-87.
2004: Timothy E Barder; Stephen L Buchwald
Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides.
Organic letters 2004;6(16):2649-52.
2004: Junghyun Chae; Stephen L Buchwald
Palladium-catalyzed regioselective hydrodebromination of dibromoindoles: application to the enantioselective synthesis of indolodioxane U86192A.
The Journal of organic chemistry 2004;69(10):3336-9.
2004: Matthew P Rainka; Yimon Aye; Stephen L Buchwald
Copper-catalyzed asymmetric conjugate reduction as a route to novel beta-azaheterocyclic acid derivatives.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):5821-3.
2004: Shawn D Walker; Timothy E Barder; Joseph R Martinelli; Stephen L Buchwald
A rationally designed universal catalyst for Suzuki-Miyaura coupling processes.
Angewandte Chemie (International ed. in English) 2004;43(14):1871-6.
2004: Artis Klapars; Sean Parris; Kevin Anderson; Stephen L Buchwald
Synthesis of medium ring nitrogen heterocycles via a tandem copper-catalyzed C-N bond formation-ring-expansion process.
Journal of the American Chemical Society 2004;126(11):3529-33.
2003: Dmitri Gelman; Stephen L Buchwald
Efficient palladium-catalyzed coupling of aryl chlorides and tosylates with terminal alkynes: use of a copper cocatalyst inhibits the reaction.
Angewandte Chemie (International ed. in English) 2003;42(48):5993-6.
2003: Kevin Anderson; Maria Mendez-Perez; Julian Priego; Stephen L Buchwald
Palladium-catalyzed amination of aryl nonaflates.
The Journal of organic chemistry 2003;68(25):9563-73.
2003: Eric R. Strieter; Donna G Blackmond; Stephen L Buchwald
Insights into the origin of high activity and stability of catalysts derived from bulky, electron-rich monophosphinobiaryl ligands in the Pd-catalyzed C-N bond formation.
Journal of the American Chemical Society 2003;125(46):13978-80.
2003: Edward J Hennessy; Stephen L Buchwald
Synthesis of substituted oxindoles from alpha-chloroacetanilides via palladium-catalyzed C[bond]H functionalization.
Journal of the American Chemical Society 2003;125(40):12084-5.
2003: Lei Jiang; Gabriel E Job; Artis Klapars; Stephen L Buchwald
Copper-catalyzed coupling of amides and carbamates with vinyl halides.
Organic letters 2003;5(20):3667-9.
2003: Hanh Nho Nguyen; Xiaohua Huang; Stephen L Buchwald
The first general palladium catalyst for the Suzuki-Miyaura and carbonyl enolate coupling of aryl arenesulfonates.
Journal of the American Chemical Society 2003;125(39):11818-9.
2003: Gregory Hughes; Masanari Kimura; Stephen L Buchwald
Catalytic enantioselective conjugate reduction of lactones and lactams.
Journal of the American Chemical Society 2003;125(37):11253-8.
2003: Valdas Jurkauskas; Joseph P Sadighi; Stephen L Buchwald
Conjugate reduction of alpha,beta-unsaturated carbonyl compounds catalyzed by a copper carbene complex.
Organic letters 2003;5(14):2417-20.
2003: Danilo Zim; Stephen L Buchwald
An air and thermally stable one- component catalyst for the amination of aryl chlorides.
Organic letters 2003;5(14):2413-5.
2003: Dmitri Gelman; Lei Jiang; Stephen L Buchwald
Copper-catalyzed C-P bond construction via direct coupling of secondary phosphines and phosphites with aryl and vinyl halides.
Organic letters 2003;5(13):2315-8.
2003: Xiaohua Huang; Kevin Anderson; Danilo Zim; Lei Jiang; Artis Klapars; Stephen L Buchwald
Expanding Pd-catalyzed C-N bond-forming processes: the first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions.
Journal of the American Chemical Society 2003;125(22):6653-5.
2003: Gero Nordmann; Stephen L Buchwald
A domino copper-catalyzed C-O coupling-Claisen rearrangement process.
Journal of the American Chemical Society 2003;125(17):4978-9.
2003: Fuk Yee Kwong; Stephen L Buchwald
Mild and efficient copper-catalyzed amination of aryl bromides with primary alkylamines.
Organic letters 2003;5(6):793-6.
2003: Jacopo Zanon; Artis Klapars; Stephen L Buchwald
Copper-catalyzed domino halide exchange-cyanation of aryl bromides.
Journal of the American Chemical Society 2003;125(10):2890-1.
2002: Jennifer L Rutherford; Matthew P Rainka; Stephen L Buchwald
An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates.
Journal of the American Chemical Society 2002;124(51):15168-9.
2002: Artis Klapars; Stephen L Buchwald
Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction.
Journal of the American Chemical Society 2002;124(50):14844-5.
2002: Utpal K Singh; Eric R. Strieter; Donna G Blackmond; Stephen L Buchwald
Mechanistic insights into the Pd(BINAP)-catalyzed amination of aryl bromides: kinetic studies under synthetically relevant conditions.
Journal of the American Chemical Society 2002;124(47):14104-14.
2002: Gabriel E Job; Stephen L Buchwald
Copper-catalyzed arylation of beta-amino alcohols.
Organic letters 2002;4(21):3703-6.
2002: Fuk Yee Kwong; Stephen L Buchwald
A general, efficient, and inexpensive catalyst system for the coupling of aryl iodides and thiols.
Organic letters 2002;4(20):3517-20.
2002: Jon C Antilla; Artis Klapars; Stephen L Buchwald
The copper-catalyzed N-arylation of indoles.
Journal of the American Chemical Society 2002;124(39):11684-8.
2002: Michele C Harris; Xiaohua Huang; Stephen L Buchwald
Improved functional group compatibility in the palladium-catalyzed synthesis of aryl amines.
Organic letters 2002;4(17):2885-8.
2002: Artis Klapars; Xiaohua Huang; Stephen L Buchwald
A general and efficient copper catalyst for the amidation of aryl halides.
Journal of the American Chemical Society 2002;124(25):7421-8.
2002: Jingjun Yin; Stephen L Buchwald
Pd-catalyzed intermolecular amidation of aryl halides: the discovery that xantphos can be trans-chelating in a palladium complex.
Journal of the American Chemical Society 2002;124(21):6043-8.
2002: Shana J Sturla; Stephen L Buchwald
Cobalt-phosphite-catalyzed asymmetric Pauson-Khand reaction.
The Journal of organic chemistry 2002;67(10):3398-403.
2002: Dirk J Spielvogel; Stephen L Buchwald
Nickel-BINAP catalyzed enantioselective alpha-arylation of alpha-substituted gamma-butyrolactones.
Journal of the American Chemical Society 2002;124(14):3500-1.
2002: Valdas Jurkauskas; Stephen L Buchwald
Dynamic kinetic resolution via asymmetric conjugate reduction: enantio- and diastereoselective synthesis of 2,4-dialkyl cyclopentanones.
Journal of the American Chemical Society 2002;124(12):2892-3.
2002: Takayuki Hamada; Stephen L Buchwald
P-chirogenic binaphthyl-substituted monophosphines: synthesis and use in enolate vinylation/arylation reactions.
Organic letters 2002;4(6):999-1001.
2002: Martina Wolter; Gero Nordmann; Gabriel E Job; Stephen L Buchwald
Copper-catalyzed coupling of aryl iodides with aliphatic alcohols.
Organic letters 2002;4(6):973-6.
2002: Fuk Yee Kwong; Artis Klapars; Stephen L Buchwald
Copper-catalyzed coupling of alkylamines and aryl iodides: an efficient system even in an air atmosphere.
Organic letters 2002;4(4):581-4.
2002: Takayuki Hamada; André Chieffi; Jens Ahman; Stephen L Buchwald
An improved catalyst for the asymmetric arylation of ketone enolates.
Journal of the American Chemical Society 2002;124(7):1261-8.
2002: Jingjun Yin; Matthew P Rainka; Xiao-Xiang Zhang; Stephen L Buchwald
A highly active Suzuki catalyst for the synthesis of sterically hindered biaryls: novel ligand coordination.
Journal of the American Chemical Society 2002;124(7):1162-3.
2002: Oliver Gaertzen; Stephen L Buchwald
Palladium-catalyzed intramolecular alpha-arylation of alpha-amino acid esters.
The Journal of organic chemistry 2002;67(2):465-75.
2002: Edward J Hennessy; Stephen L Buchwald
A general and mild copper-catalyzed arylation of diethyl malonate.
Organic letters 2002;4(2):269-72.
2002: Erasmus M Vogl; Stephen L Buchwald
Palladium-catalyzed monoarylation of nitroalkanes.
The Journal of organic chemistry 2002;67(1):106-11.
2001: S I Kuwabe; K E Torraca; Stephen L Buchwald
Palladium-catalyzed intramolecular C-O bond formation.
Journal of the American Chemical Society 2001;123(49):12202-6.
2001: M Wolter; Artis Klapars; Stephen L Buchwald
Synthesis of N-aryl hydrazides by copper-catalyzed coupling of hydrazides with aryl iodides.
Organic letters 2001;3(23):3803-5.
2001: K E Torraca; Xiaohua Huang; CA Parrish; Stephen L Buchwald
An efficient intermolecular palladium-catalyzed synthesis of aryl ethers.
Journal of the American Chemical Society 2001;123(43):10770-1.
2001: Xiaohua Huang; Stephen L Buchwald
New ammonia equivalents for the Pd-catalyzed amination of aryl halides.
Organic letters 2001;3(21):3417-9.
2001: W A Moradi; Stephen L Buchwald
Palladium-catalyzed alpha-arylation of esters.
Journal of the American Chemical Society 2001;123(33):7996-8002.
2001: Artis Klapars; Jon C Antilla; Xiaohua Huang; Stephen L Buchwald
A general and efficient copper catalyst for the amidation of aryl halides and the N-arylation of nitrogen heterocycles.
Journal of the American Chemical Society 2001;123(31):7727-9.
2001: Jon C Antilla; Stephen L Buchwald
Copper-catalyzed coupling of arylboronic acids and amines.
Organic letters 2001;3(13):2077-9.
2001: A Chieffi; K Kamikawa; J Ahman; J M Fox; Stephen L Buchwald
Catalytic asymmetric vinylation of ketone enolates.
Organic letters 2001;3(12):1897-900.
2001: CA Parrish; Stephen L Buchwald
Use of polymer-supported dialkylphosphinobiphenyl ligands for palladium-catalyzed amination and Suzuki reactions.
The Journal of organic chemistry 2001;66(11):3820-7.
2001: Mayssam H Ali; Stephen L Buchwald
An improved method for the palladium-catalyzed amination of aryl iodides.
The Journal of organic chemistry 2001;66(8):2560-5.
2001: J Yun; Stephen L Buchwald
One-pot synthesis of enantiomerically enriched 2,3-disubstituted cyclopentanones via copper-catalyzed 1,4-reduction and alkylation.
Organic letters 2001;3(8):1129-31.
2001: CA Parrish; Stephen L Buchwald
Palladium-catalyzed formation of aryl tert-butyl ethers from unactivated aryl halides.
The Journal of organic chemistry 2001;66(7):2498-500.
2000: H Tomori; J M Fox; Stephen L Buchwald
An improved synthesis of functionalized biphenyl-based phosphine ligands.
The Journal of organic chemistry 2000;65(17):5334-41.
2000: Michele C Harris; Stephen L Buchwald
One-pot synthesis of unsymmetrical triarylamines from aniline precursors.
The Journal of organic chemistry 2000;65(17):5327-33.
2000: T Hundertmark; Adam F Littke; Stephen L Buchwald; Gregory C Fu
Pd(PhCN)(2)Cl(2)/P(t-Bu)(3): a versatile catalyst for Sonogashira reactions of aryl bromides at room temperature.
Organic letters 2000;2(12):1729-31.
2000: J Yun; Stephen L Buchwald
Kinetic resolution and isomerization of 2,5-disubstituted pyrrolines.
Chirality 2000;12(5-6):476-8.
2000: D W Old; Michele C Harris; Stephen L Buchwald
Efficient palladium-catalyzed N-arylation of indoles.
Organic letters 2000;2(10):1403-6.
2000: Jingjun Yin; Stephen L Buchwald
Palladium-catalyzed intermolecular coupling of aryl halides and amides.
Organic letters 2000;2(8):1101-4.
2000: M C Hansen; Stephen L Buchwald
A method for the asymmetric hydrosilylation of N-aryl imines.
Organic letters 2000;2(5):713-5.
2000: J P Wolfe; H Tomori; Joseph P Sadighi; Jingjun Yin; Stephen L Buchwald
Simple, efficient catalyst system for the palladium-catalyzed amination of aryl chlorides, bromides, and triflates.
The Journal of organic chemistry 2000;65(4):1158-74.
2000: J P Wolfe; Stephen L Buchwald
Scope and limitations of the Pd/BINAP-catalyzed amination of aryl bromides.
The Journal of organic chemistry 2000;65(4):1144-57.
1999: B H Yang; Stephen L Buchwald
The development of efficient protocols for the palladium-catalyzed cyclization reactions of secondary amides and carbamates.
Organic letters 1999;1(1):35-7.