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george kollias
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20
Pasparakis, Manolis
16
Douni, Eleni
16
Kassiotis, George
15
Schett, Georg
14
Hayer, Silvia
12
Alexopoulou, Lena
12
Redlich, Kurt
10
Smolen, Josef
10
Steiner, Günter
10
Akassoglou, Katerina
9
Haralambous, Sylva
8
Armaka, Maria
8
Zwerina, Jochen
7
Tohidast-Akrad, Makiyeh
7
Aidinis, Vassilis
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All Publications
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2009: Victoratos Panayiotis; Kollias George
Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells.
Immunity 2009;30(1):130-42.
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2008: Gareus Ralph; Kotsaki Elena; Xanthoulea Sofia; van der Made Ingeborg; Gijbels Marion J J; Kardakaris Rozina; Polykratis Apostolos; Kollias George; de Winther Menno P J; Pasparakis Manolis
Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis.
Cell metabolism 2008;8(5):372-83.
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2008: Ermolaeva Maria A; Michallet Marie-Cécile; Papadopoulou Nikoletta; Utermöhlen Olaf; Kranidioti Ksanthi; Kollias George; Tschopp Jürg; Pasparakis Manolis
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses.
Nature immunology 2008;9(9):1037-46.
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2008: Apostolaki Maria; Manoloukos Menelaos; Roulis Manolis; Wurbel Marc-André; Müller Werner; Papadakis Konstantinos A; Kontoyiannis Dimitris L; Malissen Bernard; Kollias George
Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease.
Gastroenterology 2008;134(7):2025-35.
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2008: Huybers Sylvie; Apostolaki Maria; van der Eerden Bram C J; Kollias George; Naber Ton H J; Bindels René J M; Hoenderop Joost G J
Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters.
Inflammatory bowel diseases 2008;14(6):803-11.
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2008: Armaka Maria; Apostolaki Maria; Jacques Peggy; Kontoyiannis Dimitris L; Elewaut Dirk; Kollias George
Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases.
The Journal of experimental medicine 2008;205(2):331-7.
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2008: Schurigt Uta; Hummel Klaus M; Petrow Peter K; Gajda Mieczyslaw; Stöckigt Renate; Middel Peter; Zwerina Jochen; Janik Tobias; Bernhardt Ricardo; Schüler Susann; Scharnweber Dieter; Beckmann Felix; Saftig Paul; Kollias George; Schett Georg; Wiederanders Bernd; Bräuer Rolf
Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice.
Arthritis and rheumatism 2008;58(2):422-34.
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2008: Bobacz Klaus; Sunk Ilse-Gerlinde; Hayer Silvia; Amoyo Love; Tohidast-Akrad Makiyeh; Kollias George; Smolen Josef S; Schett Georg
Differentially regulated expression of growth differentiation factor 5 and bone morphogenetic protein 7 in articular cartilage and synovium in murine chronic arthritis: potential importance for cartilage breakdown and synovial hypertrophy.
Arthritis and rheumatism 2008;58(1):109-18.
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2008: Aidinis V; Chandras C; Manoloukos M; Thanassopoulou A; Kranidioti K; Armaka M; Douni E; Kontoyiannis D L; Zouberakis M; Kollias G;
MUGEN mouse database; animal models of human immunological diseases.
Nucleic acids research 2008;36(Database issue):D1048-54.
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2008: Pullerits Rille; Jonsson Ing-Marie; Kollias George; Tarkowski Andrej
Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling.
Arthritis research & therapy 2008;10(3):R72.
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2007: Vasilopoulos Y; Gkretsi V; Armaka M; Aidinis V; Kollias G
Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii23-8.
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2007: Van Molle Wim; Van Roy Maarten; Van Bogaert Tom; Dejager Lien; Van Lint Philippe; Vanlaere Ineke; Sekikawa Kenji; Kollias George; Libert Claude
Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy.
Cancer research 2007;67(15):7301-7.
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2007: Chatzidakis Ioannis; Fousteri Georgia; Tsoukatou Debbie; Kollias George; Mamalaki Clio
An essential role for TNF in modulating thresholds for survival, activation, and tolerance of CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6735-45.
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2007: Ye Ping; Kollias George; D'Ercole A Joseph
Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice.
Journal of neuroscience research 2007;85(4):712-22.
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2007: Douni Eleni; Armaka Maria; Kontoyiannis Dimitris L; Kollias George
Functional genetic and genomic analysis of modeled arthritis.
Advances in experimental medicine and biology 2007;602():33-42.
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2006: Alexopoulou Lena; Kranidioti Ksanthi; Xanthoulea Sofia; Denis Maria; Kotanidou Anastasia; Douni Eleni; Blackshear Perry J; Kontoyiannis Dimitris L; Kollias George
Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity.
European journal of immunology 2006;36(10):2768-80.
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2006: Boillée Séverine; Yamanaka Koji; Lobsiger Christian S; Copeland Neal G; Jenkins Nancy A; Kassiotis George; Kollias George; Cleveland Don W
Onset and progression in inherited ALS determined by motor neurons and microglia.
Science (New York, N.Y.) 2006;312(5778):1389-92.
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2006: Bamias Giorgos; Mishina Margarita; Nyce Mark; Ross William G; Kollias Giorgos; Rivera-Nieves Jesus; Pizarro Theresa T; Cominelli Fabio
Role of TL1A and its receptor DR3 in two models of chronic murine ileitis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8441-6.
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2006: Zwerina Jochen; Hayer Silvia; Redlich Kurt; Bobacz Klaus; Kollias Giorgos; Smolen Josef S; Schett Georg
Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destruction.
Arthritis and rheumatism 2006;54(2):463-72.
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2006: Victoratos Panayiotis; Lagnel Jacques; Tzima Sotiria; Alimzhanov Marat B; Rajewsky Klaus; Pasparakis Manolis; Kollias George
FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses.
Immunity 2006;24(1):65-77.
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2006: Oikonomou Nikos; Harokopos Vaggelis; Zalevsky Jonathan; Valavanis Christos; Kotanidou Anastasia; Szymkowski David E; Kollias George; Aidinis Vassilis
Soluble TNF mediates the transition from pulmonary inflammation to fibrosis.
PloS one 2006;1():e108.
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2006: Argyropoulos C; Chatziioannou A A; Nikiforidis G; Moustakas A; Kollias G; Aidinis V
Operational criteria for selecting a cDNA microarray data normalization algorithm.
Oncology reports 2006;15 Spec no.():983-96.
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2005: Hayer Silvia; Tohidast-Akrad Makiyeh; Haralambous Silva; Jahn-Schmid Beatrice; Skriner Karl; Trembleau Sylvie; Dumortier Hélène; Pinol-Roma Serafin; Redlich Kurt; Schett Georg; Muller Sylviane; Kollias George; Smolen Josef; Steiner Günter
Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-associated anti-RA33 autoantibodies in TNF-alpha transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8327-36.
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2005: Beardmore Victoria A; Hinton Heather J; Eftychi Christina; Apostolaki Maria; Armaka Maria; Darragh Joanne; McIlrath Joanne; Carr Julia M; Armit Laura J; Clacher Carol; Malone Loraine; Kollias George; Arthur J Simon C
Generation and characterization of p38beta (MAPK11) gene-targeted mice.
Molecular and cellular biology 2005;25(23):10454-64.
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2005: Zwerina Jochen; Tzima Sotiria; Hayer Silvia; Redlich Kurt; Hoffmann Oskar; Hanslik-Schnabel Beatrice; Smolen Josef S; Kollias George; Schett Georg
Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2011-3.
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2005: Hövelmeyer Nadine; Hao Zhenyue; Kranidioti Ksanthi; Kassiotis George; Buch Thorsten; Frommer Friederike; von Hoch Lennart; Kramer Dana; Minichiello Liliana; Kollias George; Lassmann Hans; Waisman Ari
Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5875-84.
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2005: Aidinis Vassilis; Carninci Piero; Armaka Maria; Witke Walter; Harokopos Vaggelis; Pavelka Norman; Koczan Dirk; Argyropoulos Christos; Thwin Maung-Maung; Möller Steffen; Waki Kazunori; Gopalakrishnakone Ponnampalam; Ricciardi-Castagnoli Paola; Thiesen Hans-Jürgen; Hayashizaki Yoshihide; Kollias George
Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.
PLoS genetics 2005;1(4):e48.
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2005: Katsanou Vicky; Papadaki Olympia; Milatos Stavros; Blackshear Perry J; Anderson Paul; Kollias George; Kontoyiannis Dimitris L
HuR as a negative posttranscriptional modulator in inflammation.
Molecular cell 2005;19(6):777-89.
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2005: Carninci P; Kasukawa T; Katayama S; Gough J; Frith M C; Maeda N; Oyama R; Ravasi T; Lenhard B; Wells C; Kodzius R; Shimokawa K; Bajic V B; Brenner S E; Batalov S; Forrest A R R; Zavolan M; Davis M J; Wilming L G; Aidinis V; Allen J E; Ambesi-Impiombato A; Apweiler R; Aturaliya R N; Bailey T L; Bansal M; Baxter L; Beisel K W; Bersano T; Bono H; Chalk A M; Chiu K P; Choudhary V; Christoffels A; Clutterbuck D R; Crowe M L; Dalla E; Dalrymple B P; de Bono B; Della Gatta G; di Bernardo D; Down T; Engstrom P; Fagiolini M; Faulkner G; Fletcher C F; Fukushima T; Furuno M; Futaki S; Gariboldi M; Georgii-Hemming P; Gingeras T R; Gojobori T; Green R E; Gustincich S; Harbers M; Hayashi Y; Hensch T K; Hirokawa N; Hill D; Huminiecki L; Iacono M; Ikeo K; Iwama A; Ishikawa T; Jakt M; Kanapin A; Katoh M; Kawasawa Y; Kelso J; Kitamura H; Kitano H; Kollias G; Krishnan S P T; Kruger A; Kummerfeld S K; Kurochkin I V; Lareau L F; Lazarevic D; Lipovich L; Liu J; Liuni S; McWilliam S; Madan Babu M; Madera M; Marchionni L; Matsuda H; Matsuzawa S; Miki H; Mignone F; Miyake S; Morris K; Mottagui-Tabar S; Mulder N; Nakano N; Nakauchi H; Ng P; Nilsson R; Nishiguchi S; Nishikawa S; Nori F; Ohara O; Okazaki Y; Orlando V; Pang K C; Pavan W J; Pavesi G; Pesole G; Petrovsky N; Piazza S; Reed J; Reid J F; Ring B Z; Ringwald M; Rost B; Ruan Y; Salzberg S L; Sandelin A; Schneider C; Schönbach C; Sekiguchi K; Semple C A M; Seno S; Sessa L; Sheng Y; Shibata Y; Shimada H; Shimada K; Silva D; Sinclair B; Sperling S; Stupka E; Sugiura K; Sultana R; Takenaka Y; Taki K; Tammoja K; Tan S L; Tang S; Taylor M S; Tegner J; Teichmann S A; Ueda H R; van Nimwegen E; Verardo R; Wei C L; Yagi K; Yamanishi H; Zabarovsky E; Zhu S; Zimmer A; Hide W; Bult C; Grimmond S M; Teasdale R D; Liu E T; Brusic V; Quackenbush J; Wahlestedt C; Mattick J S; Hume D A; Kai C; Sasaki D; Tomaru Y; Fukuda S; Kanamori-Katayama M; Suzuki M; Aoki J; Arakawa T; Iida J; Imamura K; Itoh M; Kato T; Kawaji H; Kawagashira N; Kawashima T; Kojima M; Kondo S; Konno H; Nakano K; Ninomiya N; Nishio T; Okada M; Plessy C; Shibata K; Shiraki T; Suzuki S; Tagami M; Waki K; Watahiki A; Okamura-Oho Y; Suzuki H; Kawai J; Hayashizaki Y;
The transcriptional landscape of the mammalian genome.
Science (New York, N.Y.) 2005;309(5740):1559-63.
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2005: Kollias George
TNF pathophysiology in murine models of chronic inflammation and autoimmunity.
Seminars in arthritis and rheumatism 2005;34(5 Suppl1):3-6.
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2004: Panagopoulos Dimitris; Victoratos Panayiotis; Alexiou Maria; Kollias George; Mosialos George
Comparative analysis of signal transduction by CD40 and the Epstein-Barr virus oncoprotein LMP1 in vivo.
Journal of virology 2004;78(23):13253-61.
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2004: Auwerx Johan; Avner Phil; Baldock Richard; Ballabio Andrea; Balling Rudi; Barbacid Mariano; Berns Anton; Bradley Allan; Brown Steve; Carmeliet Peter; Chambon Pierre; Cox Roger; Davidson Duncan; Davies Kay; Duboule Denis; Forejt Jiri; Granucci Francesca; Hastie Nick; de Angelis Martin Hrabé; Jackson Ian; Kioussis Dimitris; Kollias George; Lathrop Mark; Lendahl Urban; Malumbres Marcos; von Melchner Harald; Müller Werner; Partanen Juha; Ricciardi-Castagnoli Paola; Rigby Peter; Rosen Barry; Rosenthal Nadia; Skarnes Bill; Stewart A Francis; Thornton Janet; Tocchini-Valentini Glauco; Wagner Erwin; Wahli Walter; Wurst Wolfgang
The European dimension for the mouse genome mutagenesis program.
Nature genetics 2004;36(9):925-7.
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2004: Xanthoulea Sofia; Pasparakis Manolis; Kousteni Stavroula; Brakebusch Cord; Wallach David; Bauer Jan; Lassmann Hans; Kollias George
Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases.
The Journal of experimental medicine 2004;200(3):367-76.
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2004: Staelens Jan; Puimège Leen; Mahieu Tina; Pynaert Gwenda; Hochepied Tino; Vandenabeele Annelies; Grooten Johan; Kontoyiannis Dimitris; Van Roy Frans; Kollias George; Libert Claude
Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(7):537-43.
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2004: Herrak Petra; Görtz Birgit; Hayer Silvia; Redlich Kurt; Reiter Erika; Gasser Jürg; Bergmeister Helga; Kollias Giorgos; Smolen Josef S; Schett Georg
Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis.
Arthritis and rheumatism 2004;50(7):2327-37.
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2004: Smolen J S; Hayer S; Schett G; Redlich K; Aringer M; Kollias G; Wagner E; Steiner G
Autoimmunity and rheumatoid arthritis.
Autoimmunity reviews 2004;3 Suppl 1():S23.
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2004: Kollias G
Modeling the function of tumor necrosis factor in immune pathophysiology.
Autoimmunity reviews 2004;3 Suppl 1():S24-5.
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2004: Görtz Birgit; Hayer Silvia; Redlich Kurt; Zwerina Jochen; Tohidast-Akrad Makyieh; Tuerk Birgit; Hartmann Christine; Kollias George; Steiner Günter; Smolen Josef S; Schett Georg
Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(6):990-8.
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2004: Redlich Kurt; Görtz Birgit; Hayer Silvia; Zwerina Jochen; Kollias George; Steiner Günter; Smolen Josef S; Schett Georg
Overexpression of tumor necrosis factor causes bilateral sacroiliitis.
Arthritis and rheumatism 2004;50(3):1001-5.
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2004: Redlich Kurt; Görtz Birgit; Hayer Silvia; Zwerina Jochen; Doerr Nicholas; Kostenuik Paul; Bergmeister Helga; Kollias George; Steiner Günter; Smolen Josef S; Schett Georg
Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis.
The American journal of pathology 2004;164(2):543-55.
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2004: Zwerina Jochen; Hayer Silvia; Tohidast-Akrad Makiyeh; Bergmeister Helga; Redlich Kurt; Feige Ulrich; Dunstan Colin; Kollias Giorgos; Steiner Günter; Smolen Josef; Schett Georg
Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction.
Arthritis and rheumatism 2004;50(1):277-90.
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2004: Thwin Maung-Maung; Douni Eleni; Aidinis Vassilis; Kollias George; Kodama Kyoko; Sato Kazuki; Satish Ramapatna L; Mahendran Ratha; Gopalakrishnakone Ponnampalam
Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study.
Arthritis research & therapy 2004;6(3):R282-94.
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2004: Douni Eleni; Alexiou Maria; Kollias George
Genetic engineering in the mouse: tuning TNF/TNFR expression.
Methods in molecular medicine 2004;98():137-70.
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2003: Schett Georg; Redlich Kurt; Hayer Silvia; Zwerina Jochen; Bolon Brad; Dunstan Colin; Görtz Birgit; Schulz Andreas; Bergmeister Helga; Kollias Giorgos; Steiner Günter; Smolen Josef S
Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice.
Arthritis and rheumatism 2003;48(7):2042-51.
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2003: Sfikakis Petros P; Kollias George
Tumor necrosis factor biology in experimental and clinical arthritis.
Current opinion in rheumatology 2003;15(4):380-6.
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2003: Probst Hans Christian; Lagnel Jacques; Kollias George; van den Broek Maries
Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.
Immunity 2003;18(5):713-20.
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2003: Hukkanen Mika; Platts Louise A M; Haralambous Sylva; Ainola Mari; Konttinen Yrjö T; Kollias George; Polak Julia M
Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice.
The Journal of rheumatology 2003;30(4):652-9.
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2003: Ye Ping; Price Wayne; Kassiotis George; Kollias George; D'Ercole A Joseph
Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice.
Journal of neuroscience research 2003;71(5):721-31.
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2003: Akassoglou Katerina; Douni Eleni; Bauer Jan; Lassmann Hans; Kollias George; Probert Lesley
Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):709-14.
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2003: Aidinis Vassilis; Plows David; Haralambous Sylva; Armaka Maria; Papadopoulos Petros; Kanaki Maria Zambia; Koczan Dirk; Thiesen Hans Juergen; Kollias George
Functional analysis of an arthritogenic synovial fibroblast.
Arthritis research & therapy 2003;5(3):R140-57.
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2002: Kontoyiannis Dimitris; Boulougouris George; Manoloukos Menelaos; Armaka Maria; Apostolaki Maria; Pizarro Theresa; Kotlyarov Alexey; Forster Irmgard; Flavell Richard; Gaestel Matthias; Tsichlis Philip; Cominelli Fabio; Kollias George
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.
The Journal of experimental medicine 2002;196(12):1563-74.
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2002: Holtmann Martin H; Douni Eleni; Schütz Michael; Zeller Geraldine; Mudter Jonas; Lehr Hans-Anton; Gerspach Jeanette; Scheurich Peter; Galle Peter R; Kollias George; Neurath Markus F
Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo.
European journal of immunology 2002;32(11):3142-51.
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2002: Redlich Kurt; Hayer Silvia; Ricci Romeo; David Jean-Pierre; Tohidast-Akrad Makiyeh; Kollias George; Steiner Günter; Smolen Josef S; Wagner Erwin F; Schett Georg
Osteoclasts are essential for TNF-alpha-mediated joint destruction.
The Journal of clinical investigation 2002;110(10):1419-27.
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2002: Kollias George; Kontoyiannis Dimitris
Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments.
Cytokine & growth factor reviews 2002;13(4-5):315-21.
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2002: Redlich Kurt; Hayer Silvia; Maier Andrea; Dunstan Colin R; Tohidast-Akrad Makiyeh; Lang Susanne; Türk Birgit; Pietschmann Peter; Woloszczuk Wolfgang; Haralambous Silva; Kollias George; Steiner Günter; Smolen Josef S; Schett Georg
Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin.
Arthritis and rheumatism 2002;46(3):785-92.
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2002: Neininger Armin; Kontoyiannis Dimitris; Kotlyarov Alexey; Winzen Reinhard; Eckert Rolf; Volk Hans-Dieter; Holtmann Helmut; Kollias George; Gaestel Matthias
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels.
The Journal of biological chemistry 2002;277(5):3065-8.
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2002: Kollias George; Kontoyiannis Dimitris; Douni Eleni; Kassiotis George
The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies.
Current directions in autoimmunity 2002;5():30-50.
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2001: Schett G; Hayer S; Tohidast-Akrad M; Schmid B J; Lang S; Türk B; Kainberger F; Haralambous S; Kollias G; Newby A C; Xu Q; Steiner G; Smolen J
Adenovirus-based overexpression of tissue inhibitor of metalloproteinases 1 reduces tissue damage in the joints of tumor necrosis factor alpha transgenic mice.
Arthritis and rheumatism 2001;44(12):2888-98.
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2001: Kassiotis G; Kranidioti K; Kollias G
Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness.
Journal of neuroimmunology 2001;119(2):239-47.
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2001: Kontoyiannis D; Kotlyarov A; Carballo E; Alexopoulou L; Blackshear P J; Gaestel M; Davis R; Flavell R; Kollias G
Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.
The EMBO journal 2001;20(14):3760-70.
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2001: Bezzi P; Domercq M; Brambilla L; Galli R; Schols D; De Clercq E; Vescovi A; Bagetta G; Kollias G; Meldolesi J; Volterra A
CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity.
Nature neuroscience 2001;4(7):702-10.
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2001: Kassiotis G; Kollias G
TNF and receptors in organ-specific autoimmune disease: multi-layered functioning mirrored in animal models.
The Journal of clinical investigation 2001;107(12):1507-8.
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2001: Kassiotis G; Kollias G
Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination.
The Journal of experimental medicine 2001;193(4):427-34.
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2000: Dumitru C D; Ceci J D; Tsatsanis C; Kontoyiannis D; Stamatakis K; Lin J H; Patriotis C; Jenkins N A; Copeland N G; Kollias G; Tsichlis P N
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.
Cell 2000;103(7):1071-83.
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2000: Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander C A; Kollias G; Kunkel S L; Hültner L; Röcken M
Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2.
The Journal of experimental medicine 2000;192(10):1441-52.
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2000: Abu-Amer Y; Erdmann J; Alexopoulou L; Kollias G; Ross F P; Teitelbaum S L
Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis.
The Journal of biological chemistry 2000;275(35):27307-10.
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2000: Liefner M; Siebert H; Sachse T; Michel U; Kollias G; Brück W
The role of TNF-alpha during Wallerian degeneration.
Journal of neuroimmunology 2000;108(1-2):147-52.
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2000: Kontoyiannis D; Kollias G
Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor.
European journal of immunology 2000;30(7):2038-47.
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2000: White D W; Badovinac V P; Kollias G; Harty J T
Cutting edge: antilisterial activity of CD8+ T cells derived from TNF-deficient and TNF/perforin double-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):5-9.
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2000: Iyer S; Kontoyiannis D; Chevrier D; Woo J; Mori N; Cornejo M; Kollias G; Buelow R
Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide.
The Journal of biological chemistry 2000;275(22):17051-7.
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2000: Schwarz E M; Lu A P; Goater J J; Benz E B; Kollias G; Rosier R N; Puzas J E; O'Keefe R J
Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(3):472-80.
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2000: Pasparakis M; Kousteni S; Peschon J; Kollias G
Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles.
Cellular immunology 2000;201(1):33-41.
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2000: Goater J; Müller R; Kollias G; Firestein G S; Sanz I; O'Keefe R J; Schwarz E M
Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis.
The Journal of rheumatology 2000;27(4):983-9.
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2000: Mabbott N A; Williams A; Farquhar C F; Pasparakis M; Kollias G; Bruce M E
Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie.
Journal of virology 2000;74(7):3338-44.
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2000: Kontoyiannis D; Kollias G
Fibroblast biology. Synovial fibroblasts in rheumatoid arthritis: leading role or chorus line?
Arthritis research 2000;2(5):342-3.
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1999: van den Berg W B; Joosten L A; Kollias G; van De Loo F A
Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction.
Annals of the rheumatic diseases 1999;58 Suppl 1():I40-8.
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1999: Kollias G; Douni E; Kassiotis G; Kontoyiannis D
The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.
Annals of the rheumatic diseases 1999;58 Suppl 1():I32-9.
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1999: Glosli H; Veiby O P; Fjerdingstad H; Mehlum A; Probert L; Kollias G; Gjernes E; Prydz H
Effects of hTNFalpha expression in T cells on haematopoiesis in transgenic mice.
European journal of haematology 1999;63(1):50-60.
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1999: Moore R J; Owens D M; Stamp G; Arnott C; Burke F; East N; Holdsworth H; Turner L; Rollins B; Pasparakis M; Kollias G; Balkwill F
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.
Nature medicine 1999;5(7):828-31.
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1999: Kollias G; Douni E; Kassiotis G; Kontoyiannis D
On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.
Immunological reviews 1999;169():175-94.
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1999: Zhang Y; Pasparakis M; Kollias G; Simons M
Myocyte-dependent regulation of endothelial cell syndecan-4 expression. Role of TNF-alpha.
The Journal of biological chemistry 1999;274(21):14786-90.
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1999: Kontoyiannis D; Pasparakis M; Pizarro T T; Cominelli F; Kollias G
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.
Immunity 1999;10(3):387-98.
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1999: Kassiotis G; Bauer J; Akassoglou K; Lassmann H; Kollias G; Probert L
A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice.
European journal of immunology 1999;29(3):912-7.
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1999: Kassiotis G; Pasparakis M; Kollias G; Probert L
TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis.
European journal of immunology 1999;29(3):774-80.
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1999: Neurath M F; Hildner K; Becker C; Schlaak J F; Barbulescu K; Germann T; Schmitt E; Schirmacher P; Haralambous S; Pasparakis M; Meyer Zum Büschenfelde K H; Kollias G; Märker-Hermann E
Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression.
Clinical and experimental immunology 1999;115(1):42-55.
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1999: Plows D; Kontogeorgos G; Kollias G
Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1018-23.
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1999: Akassoglou K; Bauer J; Kassiotis G; Lassmann H; Kollias G; Probert L
Transgenic models of TNF induced demyelination.
Advances in experimental medicine and biology 1999;468():245-59.
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1998: Maurer M; Echtenacher B; Hültner L; Kollias G; Männel D N; Langley K E; Galli S J
The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells.
The Journal of experimental medicine 1998;188(12):2343-8.
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1998: Adorini L; Bonneville M; Kollias G
Pathogenic and protective T-cell responses in autoimmune diseases.
Research in immunology 1998;149(9):873-5.
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1998: Douni E; Kollias G
A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.
The Journal of experimental medicine 1998;188(7):1343-52.
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1998: Akassoglou K; Bauer J; Kassiotis G; Pasparakis M; Lassmann H; Kollias G; Probert L
Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.
The American journal of pathology 1998;153(3):801-13.
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1998: Alexopoulou L; Pasparakis M; Kollias G
Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function.
The Journal of experimental medicine 1998;188(4):745-54.
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1998: Fiore M; Alleva E; Probert L; Kollias G; Angelucci F; Aloe L
Exploratory and displacement behavior in transgenic mice expressing high levels of brain TNF-alpha.
Physiology & behavior 1998;63(4):571-6.
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1998: Bessis N; Chiocchia G; Kollias G; Minty A; Fournier C; Fradelizi D; Boissier M C
Modulation of proinflammatory cytokine production in tumour necrosis factor-alpha (TNF-alpha)-transgenic mice by treatment with cells engineered to secrete IL-4, IL-10 or IL-13.
Clinical and experimental immunology 1998;111(2):391-6.
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1998: Alonzi T; Fattori E; Lazzaro D; Costa P; Probert L; Kollias G; De Benedetti F; Poli V; Ciliberto G
Interleukin 6 is required for the development of collagen-induced arthritis.
The Journal of experimental medicine 1998;187(4):461-8.
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1998: Tselios T; Probert L; Kollias G; Matsoukas E; Roumelioti P; Alexopoulos K; Moore G J; Matsoukas J
Design and synthesis of small semi-mimetic peptides with immunomodulatory activity based on myelin basic protein (MBP).
Amino acids 1998;14(4):333-41.
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1997: Küsters S; Tiegs G; Alexopoulou L; Pasparakis M; Douni E; Künstle G; Bluethmann H; Wendel A; Pfizenmaier K; Kollias G; Grell M
In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.
European journal of immunology 1997;27(11):2870-5.
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1997: Alexopoulou L; Pasparakis M; Kollias G
A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling.
European journal of immunology 1997;27(10):2588-92.
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1997: Plumier J C; Krueger A M; Currie R W; Kontoyiannis D; Kollias G; Pagoulatos G N
Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury.
Cell stress & chaperones 1997;2(3):162-7.
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1997: Butler D M; Malfait A M; Mason L J; Warden P J; Kollias G; Maini R N; Feldmann M; Brennan F M
DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2867-76.
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1997: Ventre J; Doebber T; Wu M; MacNaul K; Stevens K; Pasparakis M; Kollias G; Moller D E
Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.
Diabetes 1997;46(9):1526-31.
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1997: Neurath M F; Fuss I; Pasparakis M; Alexopoulou L; Haralambous S; Meyer zum Büschenfelde K H; Strober W; Kollias G
Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice.
European journal of immunology 1997;27(7):1743-50.
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1997: Pasparakis M; Alexopoulou L; Grell M; Pfizenmaier K; Bluethmann H; Kollias G
Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6319-23.
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1997: Cope A P; Liblau R S; Yang X D; Congia M; Laudanna C; Schreiber R D; Probert L; Kollias G; McDevitt H O
Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling.
The Journal of experimental medicine 1997;185(9):1573-84.
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1997: Probert L; Akassoglou K; Kassiotis G; Pasparakis M; Alexopoulou L; Kollias G
TNF-alpha transgenic and knockout models of CNS inflammation and degeneration.
Journal of neuroimmunology 1997;72(2):137-41.
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1997: Akassoglou K; Probert L; Kontogeorgos G; Kollias G
Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):438-45.
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1996: Pasparakis M; Alexopoulou L; Douni E; Kollias G
Tumour necrosis factors in immune regulation: everything that's interesting is...new!
Cytokine & growth factor reviews 1996;7(3):223-9.
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1996: Pasparakis M; Alexopoulou L; Episkopou V; Kollias G
Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.
The Journal of experimental medicine 1996;184(4):1397-411.
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1996: Fiore M; Probert L; Kollias G; Akassoglou K; Alleva E; Aloe L
Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain.
Brain, behavior, and immunity 1996;10(2):126-38.
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1996: Probert L; Akassoglou K; Alexopoulou L; Douni E; Haralambous S; Hill S; Kassiotis G; Kontoyiannis D; Pasparakis M; Plows D; Kollias G
Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice.
Journal of leukocyte biology 1996;59(4):518-25.
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1996: Georgopoulos S; Plows D; Kollias G
Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice.
Journal of inflammation 1996;46(2):86-97.
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1995: Grell M; Douni E; Wajant H; Löhden M; Clauss M; Maxeiner B; Georgopoulos S; Lesslauer W; Kollias G; Pfizenmaier K; Scheurich P
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.
Cell 1995;83(5):793-802.
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1995: Probert L; Akassoglou K; Pasparakis M; Kontogeorgos G; Kollias G
Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11294-8.
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1995: Probert L; Plows D; Kontogeorgos G; Kollias G
The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice.
European journal of immunology 1995;25(6):1794-7.
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1995: Plumier J C; Ross B M; Currie R W; Angelidis C E; Kazlaris H; Kollias G; Pagoulatos G N
Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
The Journal of clinical investigation 1995;95(4):1854-60.
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1995: Siegel S A; Shealy D J; Nakada M T; Le J; Woulfe D S; Probert L; Kollias G; Ghrayeb J; Vilcek J; Daddona P E
The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo.
Cytokine 1995;7(1):15-25.
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1995: Douni E; Akassoglou K; Alexopoulou L; Georgopoulos S; Haralambous S; Hill S; Kassiotis G; Kontoyiannis D; Pasparakis M; Plows D; Probert L; Kollias G
Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.
Journal of inflammation 1995;47(1-2):27-38.
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1995: Aloe L; Probert L; Kollias G; Micera A; Tirassa P
Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice.
Rheumatology international 1995;14(6):249-52.
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1993: Probert L; Keffer J; Corbella P; Cazlaris H; Patsavoudi E; Stephens S; Kaslaris E; Kioussis D; Kollias G
Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):1894-906.
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1993: Aloe L; Probert L; Kollias G; Bracci-Laudiero L; Spillantini M G; Levi-Montalcini R
The synovium of transgenic arthritic mice expressing human tumor necrosis factor contains a high level of nerve growth factor.
Growth factors (Chur, Switzerland) 1993;9(2):149-55.
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1993: Aloe L; Probert L; Kollias G; Bracci-Laudiero L; Micera A; Mollinari C; Levi-Montalcini R
Level of nerve growth factor and distribution of mast cells in the synovium of tumour necrosis factor transgenic arthritic mice.
International journal of tissue reactions 1993;15(4):139-43.
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1991: Keffer J; Probert L; Cazlaris H; Georgopoulos S; Kaslaris E; Kioussis D; Kollias G
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
The EMBO journal 1991;10(13):4025-31.
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