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george kollias

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Manolis Roulis; Maria Armaka; Menelaos Manoloukos; Maria Apostolaki; george kollias
Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology.
Andreas Hess; Roland Axmann; Juergen Rech; Stefanie Finzel; Cornelia Heindl; Silke Kreitz; Marina Sergeeva; Marc Saake; Meritxell Garcia; george kollias; Rainer H Straub; Olaf Sporns; Arnd Doerfler; Kay Brune; Georg Schett
Blockade of TNF-α rapidly inhibits pain responses in the central nervous system.
Antreas Afantitis; Georgia Melagraki; Panayiotis A Koutentis; Haralambos Sarimveis; george kollias
Ligand-based virtual screening procedure for the prediction and the identification of novel β-amyloid aggregation inhibitors using Kohonen maps and Counterpropagation Artificial Neural Networks.

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All Publications

2011: Manolis Roulis; Maria Armaka; Menelaos Manoloukos; Maria Apostolaki; george kollias
Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(13):5396-401.
2011: Andreas Hess; Roland Axmann; Juergen Rech; Stefanie Finzel; Cornelia Heindl; Silke Kreitz; Marina Sergeeva; Marc Saake; Meritxell Garcia; george kollias; Rainer H Straub; Olaf Sporns; Arnd Doerfler; Kay Brune; Georg Schett
Blockade of TNF-α rapidly inhibits pain responses in the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(9):3731-6.
2011: Antreas Afantitis; Georgia Melagraki; Panayiotis A Koutentis; Haralambos Sarimveis; george kollias
Ligand-based virtual screening procedure for the prediction and the identification of novel β-amyloid aggregation inhibitors using Kohonen maps and Counterpropagation Artificial Neural Networks.
European journal of medicinal chemistry 2011;46(2):497-508.
2010: Georgia Melagraki; Antreas Afantitis; Haralambos Sarimveis; Olga Igglessi-Markopoulou; Panayiotis A Koutentis; george kollias
In silico exploration for identifying structure-activity relationship of MEK inhibition and oral bioavailability for isothiazole derivatives.
Chemical biology & drug design 2010;76(5):397-406.
2010: A Viejo-Borbolla; A P Martin; L R Muniz; L Shang; F Marchesi; N Thirunarayanan; N Harpaz; R A Garcia; M Apostolaki; G C Furtado; L Mayer; george kollias; A Alcami; S A Lira
Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD.
Mucosal immunology 2010;3(6):633-44.
2010: Maria Apostolaki; Maria Armaka; Panayiotis Victoratos; george kollias
Cellular mechanisms of TNF function in models of inflammation and autoimmunity.
Current directions in autoimmunity 2010;11():1-26.
2009: Panayiotis Victoratos; george kollias
Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells.
Immunity 2009;30(1):130-42.
2009: Maung-Maung Thwin; Eleni Douni; Pachiappan Arjunan; george kollias; Prem V Kumar; Ponnampalam Gopalakrishnakone
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
Arthritis research & therapy 2009;11(5):R138.
2008: Ralph Gareus; Elena Kotsaki; Sofia Xanthoulea; Ingeborg van der Made; Marion J J Gijbels; Rozina Kardakaris; Apostolos Polykratis; george kollias; Menno P J de Winther; Manolis Pasparakis
Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis.
Cell metabolism 2008;8(5):372-83.
2008: Maria A Ermolaeva; Marie-Cécile Michallet; Nikoletta Papadopoulou; Olaf Utermöhlen; Ksanthi Kranidioti; george kollias; Jürg Tschopp; Manolis Pasparakis
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses.
Nature immunology 2008;9(9):1037-46.
2008: Maria Apostolaki; Menelaos Manoloukos; Manolis Roulis; Marc-André Wurbel; Werner Müller; Werner Muller; Dimitris L Kontoyiannis; Bernard Malissen; george kollias
Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease.
Gastroenterology 2008;134(7):2025-35.
2008: Sylvie Huybers; Maria Apostolaki; Bram C J van der Eerden; george kollias; Ton H J Naber; René J M Bindels; Joost G J Hoenderop
Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters.
Inflammatory bowel diseases 2008;14(6):803-11.
2008: Maria Armaka; Maria Apostolaki; Peggy Jacques; Dimitris L Kontoyiannis; Dirk Elewaut; george kollias
Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases.
The Journal of experimental medicine 2008;205(2):331-7.
2008: Uta Schurigt; Klaus M Hummel; Peter Petrow; Mieczyslaw Gajda; Renate Stöckigt; Peter Middel; Jochen Zwerina; Tobias Janik; Ricardo Bernhardt; Susann Schüler; Dieter Scharnweber; Felix Beckmann; Paul Saftig; george kollias; Georg Schett; Bernd Wiederanders; Rolf Bräuer
Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice.
Arthritis and rheumatism 2008;58(2):422-34.
2008: Rille Pullerits; Ing-Marie Jonsson; george kollias; Andrej Tarkowski
Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling.
Arthritis research & therapy 2008;10(3):R72.
2008: Klaus Bobacz; Ilse-Gerlinde Sunk; Silvia Hayer; Love Amoyo; Makiyeh Tohidast-Akrad; george kollias; Josef S Smolen; Georg Schett
Differentially regulated expression of growth differentiation factor 5 and bone morphogenetic protein 7 in articular cartilage and synovium in murine chronic arthritis: potential importance for cartilage breakdown and synovial hypertrophy.
Arthritis and rheumatism 2008;58(1):109-18.
2008: Vassilis Aidinis; C Chandras; M Manoloukos; Artemis Thanassopoulou; Ksanthi Kranidioti; Maria Armaka; Eleni Douni; Dimitris L Kontoyiannis; M Zouberakis; george kollias
MUGEN mouse database; animal models of human immunological diseases.
Nucleic acids research 2008;36(Database issue):D1048-54.
2007: Y Vasilopoulos; V Gkretsi; Maria Armaka; Vassilis Aidinis; george kollias
Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii23-8.
2007: Wim Van Molle; Maarten Van Roy; Tom Van Bogaert; Lien Dejager; Philippe Van Lint; Ineke Vanlaere; Kenji Sekikawa; george kollias; Claude Libert
Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy.
Cancer research 2007;67(15):7301-7.
2007: Ioannis Chatzidakis; Georgia Fousteri; Debbie Tsoukatou; george kollias; Clio Mamalaki
An essential role for TNF in modulating thresholds for survival, activation, and tolerance of CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6735-45.
2007: Ping Ye; george kollias; Augustine D'ercole
Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice.
Journal of neuroscience research 2007;85(4):712-22.
2007: Eleni Douni; Maria Armaka; Dimitris L Kontoyiannis; george kollias
Functional genetic and genomic analysis of modeled arthritis.
Advances in experimental medicine and biology 2007;602():33-42.
2006: Lena Alexopoulou; Ksanthi Kranidioti; Sofia Xanthoulea; Maria Denis; Anastasia Kotanidou; Eleni Douni; Perry Blackshear; Dimitris L Kontoyiannis; george kollias
Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity.
European journal of immunology 2006;36(10):2768-80.
2006: Séverine Boillée; Koji Yamanaka; Christian S Lobsiger; Neal G Copeland; Nancy A Jenkins; George Kassiotis; george kollias; Don W Cleveland
Onset and progression in inherited ALS determined by motor neurons and microglia.
Science (New York, N.Y.) 2006;312(5778):1389-92.
2006: Giorgos Bamias; Margarita Mishina; Mark Nyce; William G Ross; george kollias; Jesús Rivera-Nieves; Theresa T Pizarro; Fabio Cominelli
Role of TL1A and its receptor DR3 in two models of chronic murine ileitis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8441-6.
2006: Jochen Zwerina; Silvia Hayer; Kurt Redlich; Klaus Bobacz; george kollias; Josef S Smolen; Georg Schett
Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destruction.
Arthritis and rheumatism 2006;54(2):463-72.
2006: Nikos Oikonomou; Vaggelis Harokopos; Jonathan Zalevsky; Christos Valavanis; Anastasia Kotanidou; David Szymkowski; george kollias; Vassilis Aidinis
Soluble TNF mediates the transition from pulmonary inflammation to fibrosis.
PloS one 2006;1():e108.
2006: Christos Argyropoulos; A A Chatziioannou; George Nikiforidis; A Moustakas; george kollias; Vassilis Aidinis
Operational criteria for selecting a cDNA microarray data normalization algorithm.
Oncology reports 2006;15 Spec no.():983-96.
2006: Panayiotis Victoratos; Jacques Lagnel; sotiria tzima; Marat B Alimzhanov; Klaus Rajewsky; Manolis Pasparakis; george kollias
FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses.
Immunity 2006;24(1):65-77.
2005: Silvia Hayer; Makiyeh Tohidast-Akrad; Sylva Haralambous; Beatrice Jahn-Schmid; Karl Skriner; Sylvie Trembleau; Hélène Dumortier; Serafin Pinol-Roma; Kurt Redlich; Georg Schett; Sylviane Muller; george kollias; Josef Smolen; Günter Steiner
Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-associated anti-RA33 autoantibodies in TNF-alpha transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8327-36.
2005: Victoria A Beardmore; Heather J Hinton; Christina Eftychi; Maria Apostolaki; Maria Armaka; Joanne Darragh; Joanne McIlrath; Julia M Carr; Laura J Armit; Carol Clacher; Loraine Malone; george kollias; J Simon C Arthur
Generation and characterization of p38beta (MAPK11) gene-targeted mice.
Molecular and cellular biology 2005;25(23):10454-64.
2005: Jochen Zwerina; sotiria tzima; Silvia Hayer; Kurt Redlich; Oskar Hoffmann; Beatrice Hanslik-Schnabel; Josef S Smolen; george kollias; Georg Schett
Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2011-3.
2005: Nadine Hövelmeyer; Zhenyue Hao; Ksanthi Kranidioti; George Kassiotis; Thorsten Buch; Friederike Frommer; Lennart von Hoch; Dana Kramer; Liliana Minichiello; george kollias; Hans Lassmann; Ari Waisman
Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5875-84.
2005: Vassilis Aidinis; piero carninci; Maria Armaka; Walter Witke; Vaggelis Harokopos; Norman Pavelka; Dirk Koczan; Christos Argyropoulos; Maung-Maung Thwin; Steffen Möller; Kazunori Waki; Waki Kazunori; Ponnampalam Gopalakrishnakone; Paola Ricciardi-Castagnoli; Hans-Jürgen Thiesen; Yoshihide Hayashizaki; george kollias
Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.
PLoS genetics 2005;1(4):e48.
2005: Vicky Katsanou; Olympia Papadaki; Stavros Milatos; Perry Blackshear; Paul Anderson; george kollias; Dimitris L Kontoyiannis
HuR as a negative posttranscriptional modulator in inflammation.
Molecular cell 2005;19(6):777-89.
2005: piero carninci; T Kasukawa; S Katayama; J Gough; M C Frith; N Maeda; R Oyama; T Ravasi; B Lenhard; C Wells; R Kodzius; K Shimokawa; Vladimir Bajic; S E Brenner; S Batalov; Alistair Forrest; M Zavolan; M J Davis; L G Wilming; V Aidinis; J E Allen; A Ambesi-Impiombato; R Apweiler; R N Aturaliya; Timothy Lawrence Bailey; M Bansal; L Baxter; K W Beisel; Tom Bersano; H Bono; Alistair Chalk; K P Chiu; V Choudhary; A Christoffels; D R Clutterbuck; M L Crowe; E Dalla; B P Dalrymple; B de Bono; G Della Gatta; D di Bernardo; T Down; P Engstrom; M Fagiolini; G Faulkner; C F Fletcher; T Fukushima; M Furuno; S Futaki; manuela gariboldi; P Georgii-Hemming; Thomas Gingeras; Takashi Gojobori; R E Green; S Gustincich; M Harbers; Y Hayashi; T K Hensch; N Hirokawa; D Hill; L Huminiecki; M Iacono; Kazuho Ikeo; A Iwama; T Ishikawa; M Jakt; Alexander Kanapin; M Katoh; Y Kawasawa; J Kelso; H Kitamura; H Kitano; george kollias; S P T Krishnan; A Kruger; S K Kummerfeld; I V Kurochkin; L F Lareau; D Lazarevic; Leonard Lipovich; J Liu; S Liuni; S McWilliam; M Madan Babu; M Madera; LUIGI MARCHIONNI; H Matsuda; S Matsuzawa; H Miki; F Mignone; S Miyake; K Morris; S Mottagui-Tabar; N Mulder; N Nakano; H Nakauchi; P Ng; R Nilsson; S Nishiguchi; S Nishikawa; F Nori; O Ohara; Yasushi Okazaki; V Orlando; K C Pang; W J Pavan; G Pavesi; G Pesole; Nikolai Petrovsky; S Piazza; J Reed; J F Reid; B Z Ring; M Ringwald; B Rost; Y Ruan; Steven L Salzberg; A Sandelin; C Schneider; Christian Schönbach; K Sekiguchi; Colin Semple; S Seno; L Sessa; Y Sheng; Y Shibata; H Shimada; K Shimada; D Silva; B Sinclair; S Sperling; Elia Stupka; K Sugiura; R Sultana; Y Takenaka; K Taki; K Tammoja; S L Tan; S Tang; Martin Taylor; J Tegner; S A Teichmann; H R Ueda; E van Nimwegen; R Verardo; C L Wei; K Yagi; H Yamanishi; E Zabarovsky; S Zhu; A Zimmer; Winston Hide; Carol Bult; S M Grimmond; Rohan Teasdale; Edison Liu; V Brusic; John Quackenbush; Claes Wahlestedt; J S Mattick; D A Hume; C Kai; D Sasaki; Y Tomaru; S Fukuda; M Kanamori-Katayama; M Suzuki; J Aoki; T Arakawa; J Iida; K Imamura; Masayoshi Itoh; T Kato; Hideya Kawaji; N Kawagashira; T Kawashima; M Kojima; S Kondo; H Konno; K Nakano; N Ninomiya; T Nishio; M Okada; C Plessy; K Shibata; T Shiraki; S Suzuki; M Tagami; Kazunori Waki; A Watahiki; Y Okamura-Oho; H Suzuki; J Kawai; Y Hayashizaki
The transcriptional landscape of the mammalian genome.
Science (New York, N.Y.) 2005;309(5740):1559-63.
2005: george kollias
TNF pathophysiology in murine models of chronic inflammation and autoimmunity.
Seminars in arthritis and rheumatism 2005;34(5 Suppl1):3-6.
2004: Dimitris Panagopoulos; Panayiotis Victoratos; Maria Alexiou; george kollias; George Mosialos
Comparative analysis of signal transduction by CD40 and the Epstein-Barr virus oncoprotein LMP1 in vivo.
Journal of virology 2004;78(23):13253-61.
2004: Johan Auwerx; Phil Avner; Richard Baldock; Andrea Ballabio; Rudi Balling; Mariano Barbacid; Anton Berns; Allan Bradley; Steve Brown; Peter Carmeliet; Pierre Chambon; Roger Cox; Duncan Davidson; Kay Davies; Denis Duboule; Jiri Forejt; Francesca Granucci; Nick Hastie; Martin Hrabé de Angelis; Ian Jackson; Dimitris Kioussis; george kollias; Mark Lathrop; Urban Lendahl; Marcos Malumbres; Harald von Melchner; Werner Muller; Juha Partanen; Paola Ricciardi-Castagnoli; Peter Rigby; Barry P Rosen; Nadia Rosenthal; Bill Skarnes; A Francis Stewart; Janet Thornton; Glauco Tocchini-Valentini; Erwin Wagner; Walter Wahli; Wolfgang Wurst
The European dimension for the mouse genome mutagenesis program.
Nature genetics 2004;36(9):925-7.
2004: Sofia Xanthoulea; Manolis Pasparakis; Stavroula Kousteni; Cord Brakebusch; David Wallach; Jan Bauer; Hans Lassmann; george kollias
Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases.
The Journal of experimental medicine 2004;200(3):367-76.
2004: Jeroen Staelens; Leen Puimège; Tina Mahieu; Gwenda Pynaert; Tino Hochepied; Annelies Vandenabeele; Johan Grooten; Dimitris L Kontoyiannis; Frans van Roy; george kollias; Claude Libert
Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(7):537-43.
2004: Petra Herrak; Birgit Görtz; Silvia Hayer; Kurt Redlich; Erika Reiter; Jürg Gasser; Helga Bergmeister; george kollias; Josef S Smolen; Georg Schett
Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis.
Arthritis and rheumatism 2004;50(7):2327-37.
2004: J S Smolen; Silvia Hayer; Georg Schett; Kurt Redlich; Martin Aringer; george kollias; E Wagner; Günter Steiner
Autoimmunity and rheumatoid arthritis.
Autoimmunity reviews 2004;3 Suppl 1():S23.
2004: george kollias
Modeling the function of tumor necrosis factor in immune pathophysiology.
Autoimmunity reviews 2004;3 Suppl 1():S24-5.
2004: Birgit Görtz; Silvia Hayer; Kurt Redlich; Jochen Zwerina; Makiyeh Tohidast-Akrad; Birgit Tuerk; Christine Hartmann; george kollias; Günter Steiner; Josef S Smolen; Georg Schett
Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(6):990-8.
2004: Kurt Redlich; Birgit Görtz; Silvia Hayer; Jochen Zwerina; george kollias; Günter Steiner; Josef S Smolen; Georg Schett
Overexpression of tumor necrosis factor causes bilateral sacroiliitis.
Arthritis and rheumatism 2004;50(3):1001-5.
2004: Kurt Redlich; Birgit Görtz; Silvia Hayer; Jochen Zwerina; Nicholas Doerr; Paul J Kostenuik; Helga Bergmeister; george kollias; Günter Steiner; Josef S Smolen; Georg Schett
Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis.
The American journal of pathology 2004;164(2):543-55.
2004: Maung-Maung Thwin; Eleni Douni; Vassilis Aidinis; george kollias; Kyoko Kodama; Kazuki Sato; Ramapatna L Satish; Ratha Mahendran; Ponnampalam Gopalakrishnakone
Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study.
Arthritis research & therapy 2004;6(3):R282-94.
2004: Eleni Douni; Maria Alexiou; george kollias
Genetic engineering in the mouse: tuning TNF/TNFR expression.
Methods in molecular medicine 2004;98():137-70.
2004: Jochen Zwerina; Silvia Hayer; Makiyeh Tohidast-Akrad; Helga Bergmeister; Kurt Redlich; Ulrich Feige; Colin Dunstan; george kollias; Günter Steiner; Josef Smolen; Georg Schett
Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction.
Arthritis and rheumatism 2004;50(1):277-90.
2003: Georg Schett; Kurt Redlich; Silvia Hayer; Jochen Zwerina; Brad Bolon; Colin Dunstan; Birgit Görtz; Andreas Schulz; Helga Bergmeister; george kollias; Günter Steiner; Josef S Smolen
Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice.
Arthritis and rheumatism 2003;48(7):2042-51.
2003: Petros P Sfikakis; george kollias
Tumor necrosis factor biology in experimental and clinical arthritis.
Current opinion in rheumatology 2003;15(4):380-6.
2003: Hans Christian Probst; Jacques Lagnel; george kollias; Maries van den Broek
Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.
Immunity 2003;18(5):713-20.
2003: Mika Hukkanen; Louise A M Platts; Sylva Haralambous; Mari Ainola; Yrjö T Konttinen; george kollias; Julia M Polak
Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice.
The Journal of rheumatology 2003;30(4):652-9.
2003: Ping Ye; Wayne A Price; George Kassiotis; george kollias; Augustine D'ercole
Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice.
Journal of neuroscience research 2003;71(5):721-31.
2003: Katerina Akassoglou; Eleni Douni; Jan Bauer; Hans Lassmann; george kollias; Lesley Probert
Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):709-14.
2003: Vassilis Aidinis; David Plows; Sylva Haralambous; Maria Armaka; Petros Papadopoulos; Maria Zambia Kanaki; Dirk Koczan; Hans Juergen Thiesen; george kollias
Functional analysis of an arthritogenic synovial fibroblast.
Arthritis research & therapy 2003;5(3):R140-57.
2002: Dimitris L Kontoyiannis; George Boulougouris; Menelaos Manoloukos; Maria Armaka; Maria Apostolaki; Theresa T Pizarro; Alexey Kotlyarov; Irmgard Forster; Richard Flavell; Matthias Gaestel; Philip Tsichlis; Fabio Cominelli; george kollias
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.
The Journal of experimental medicine 2002;196(12):1563-74.
2002: Martin H Holtmann; Eleni Douni; Michael Schütz; Geraldine Zeller; Jonas Mudter; Hans-Anton Lehr; Jeannette Gerspach; Peter Scheurich; Peter R Galle; george kollias; Markus F Neurath
Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo.
European journal of immunology 2002;32(11):3142-51.
2002: Kurt Redlich; Silvia Hayer; Romeo Ricci; Jean-Pierre David; Makiyeh Tohidast-Akrad; george kollias; Günter Steiner; Josef S Smolen; Erwin F Wagner; Georg Schett
Osteoclasts are essential for TNF-alpha-mediated joint destruction.
The Journal of clinical investigation 2002;110(10):1419-27.
2002: george kollias; Dimitris L Kontoyiannis
Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments.
Cytokine & growth factor reviews 2002;13(4-5):315-21.
2002: Kurt Redlich; Silvia Hayer; Andrea Maier; Colin Dunstan; Makiyeh Tohidast-Akrad; Susanne Lang; Birgit Türk; Peter Pietschmann; Wolfgang Woloszczuk; Sylva Haralambous; george kollias; Günter Steiner; Josef S Smolen; Georg Schett
Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin.
Arthritis and rheumatism 2002;46(3):785-92.
2002: Armin Neininger; Dimitris L Kontoyiannis; Alexey Kotlyarov; Reinhard Winzen; Rolf Eckert; Hans-Dieter Volk; Helmut Holtmann; george kollias; Matthias Gaestel
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels.
The Journal of biological chemistry 2002;277(5):3065-8.
2002: george kollias; Dimitris L Kontoyiannis; Eleni Douni; George Kassiotis
The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies.
Current directions in autoimmunity 2002;5():30-50.
2001: Georg Schett; Silvia Hayer; Makiyeh Tohidast-Akrad; B J Schmid; Susanne Lang; Birgit Türk; Franz Kainberger; Sylva Haralambous; george kollias; A C Newby; Qingbo Xu; Günter Steiner; Josef Smolen
Adenovirus-based overexpression of tissue inhibitor of metalloproteinases 1 reduces tissue damage in the joints of tumor necrosis factor alpha transgenic mice.
Arthritis and rheumatism 2001;44(12):2888-98.
2001: George Kassiotis; Ksanthi Kranidioti; george kollias
Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness.
Journal of neuroimmunology 2001;119(2):239-47.
2001: Dimitris L Kontoyiannis; Alexey Kotlyarov; Ester Carballo; Lena Alexopoulou; Perry Blackshear; Matthias Gaestel; R Davis; R Flavell; george kollias
Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.
The EMBO journal 2001;20(14):3760-70.
2001: Paola Bezzi; María Domercq; Liliana Brambilla; R Galli; D Schols; E De Clercq; Angelo L Vescovi; G Bagetta; george kollias; Jacopo Meldolesi; Andrea Volterra
CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity.
Nature neuroscience 2001;4(7):702-10.
2001: George Kassiotis; george kollias
TNF and receptors in organ-specific autoimmune disease: multi-layered functioning mirrored in animal models.
The Journal of clinical investigation 2001;107(12):1507-8.
2001: George Kassiotis; george kollias
Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination.
The Journal of experimental medicine 2001;193(4):427-34.
2000: Calin D Dumitru; JD Ceci; Christos Tsatsanis; Dimitris L Kontoyiannis; K Stamatakis; Jun-Hsiang Lin; Christos Patriotis; N A Jenkins; N G Copeland; george kollias; Philip Tsichlis
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.
Cell 2000;103(7):1071-83.
2000: Tilo Biedermann; Manfred Kneilling; Reinhard Mailhammer; Konrad Maier; Christian Sander; george kollias; Steven Kunkel; Lothar Hültner; Martin Röcken
Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2.
The Journal of experimental medicine 2000;192(10):1441-52.
2000: Yousef Abu-Amer; J Erdmann; L Alexopoulou; george kollias; F Patrick Ross; S L Teitelbaum
Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis.
The Journal of biological chemistry 2000;275(35):27307-10.
2000: M Liefner; Heike Siebert; T Sachse; Uwe Michel; george kollias; Wolfgang Brück
The role of TNF-alpha during Wallerian degeneration.
Journal of neuroimmunology 2000;108(1-2):147-52.
2000: Dimitris L Kontoyiannis; george kollias
Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor.
European journal of immunology 2000;30(7):2038-47.
2000: DW White; Vladimir P Badovinac; george kollias; John T Harty
Cutting edge: antilisterial activity of CD8+ T cells derived from TNF-deficient and TNF/perforin double-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):5-9.
2000: Suhasini Iyer; Dimitris L Kontoyiannis; D Chevrier; J Woo; N Mori; MC Cornejo; george kollias; R Buelow
Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide.
The Journal of biological chemistry 2000;275(22):17051-7.
2000: Edward M Schwarz; A P Lu; J Jeffrey Goater; E B Benz; george kollias; Randy N Rosier; J Edward Puzas; Regis J O'Keefe
Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(3):472-80.
2000: Manolis Pasparakis; Stavroula Kousteni; J Peschon; george kollias
Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles.
Cellular immunology 2000;201(1):33-41.
2000: J Jeffrey Goater; R Müller; george kollias; Gary S Firestein; Iñaki Sanz; Regis J O'Keefe; Edward M Schwarz
Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis.
The Journal of rheumatology 2000;27(4):983-9.
2000: Neil A Mabbott; A Williams; Christine F Farquhar; M Pasparakis; george kollias; Moira E Bruce
Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie.
Journal of virology 2000;74(7):3338-44.
2000: Dimitris L Kontoyiannis; george kollias
Fibroblast biology. Synovial fibroblasts in rheumatoid arthritis: leading role or chorus line?
Arthritis research 2000;2(5):342-3.
1999: Wim B van den Berg; Leo A B Joosten; george kollias; F A van De Loo
Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction.
Annals of the rheumatic diseases 1999;58 Suppl 1():I40-8.
1999: george kollias; Eleni Douni; George Kassiotis; Dimitris L Kontoyiannis
The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.
Annals of the rheumatic diseases 1999;58 Suppl 1():I32-9.
1999: Heidi Glosli; O P Veiby; Hege B Fjerdingstad; Anja Mehlum; L Probert; george kollias; Elisabet Gjernes; Hans Prydz
Effects of hTNFalpha expression in T cells on haematopoiesis in transgenic mice.
European journal of haematology 1999;63(1):50-60.
1999: Robert J Moore; D M Owens; Gordon Stamp; Caroline H Arnott; Frances Burke; Nick East; H Holdsworth; L Turner; Barrett J Rollins; M Pasparakis; george kollias; Frances R Balkwill
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.
Nature medicine 1999;5(7):828-31.
1999: george kollias; Eleni Douni; George Kassiotis; Dimitris L Kontoyiannis
On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.
Immunological reviews 1999;169():175-94.
1999: Y Zhang; M Pasparakis; george kollias; Michael Simons
Myocyte-dependent regulation of endothelial cell syndecan-4 expression. Role of TNF-alpha.
The Journal of biological chemistry 1999;274(21):14786-90.
1999: Dimitris L Kontoyiannis; Manolis Pasparakis; Theresa T Pizarro; Fabio Cominelli; george kollias
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.
Immunity 1999;10(3):387-98.
1999: George Kassiotis; Jan Bauer; Katerina Akassoglou; Hans Lassmann; george kollias; Lesley Probert
A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice.
European journal of immunology 1999;29(3):912-7.
1999: George Kassiotis; Manolis Pasparakis; george kollias; Lesley Probert
TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis.
European journal of immunology 1999;29(3):774-80.
1999: D Plows; G Kontogeorgos; george kollias
Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1018-23.
1999: Katerina Akassoglou; Jan Bauer; George Kassiotis; Hans Lassmann; george kollias; Lesley Probert
Transgenic models of TNF induced demyelination.
Advances in experimental medicine and biology 1999;468():245-59.
1999: Markus F Neurath; Kai M Hildner; Christoph Becker; Joerg F Schlaak; K Barbulescu; T Germann; Edgar Schmitt; Peter Schirmacher; Sylva Haralambous; Manolis Pasparakis; Karl-Hermann Meyer zum Büschenfelde; george kollias; Elisabeth Märker-Hermann
Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression.
Clinical and experimental immunology 1999;115(1):42-55.
1998: Marcus Maurer; Bernd Echtenacher; Lothar Hültner; george kollias; Daniela N Männel; K E Langley; S J Galli
The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells.
The Journal of experimental medicine 1998;188(12):2343-8.
1998: L Adorini; M Bonneville; george kollias
Pathogenic and protective T-cell responses in autoimmune diseases.
Research in immunology 1998;149(9):873-5.
1998: Eleni Douni; george kollias
A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.
The Journal of experimental medicine 1998;188(7):1343-52.
1998: Katerina Akassoglou; Jan Bauer; George Kassiotis; Manolis Pasparakis; Hans Lassmann; george kollias; Lesley Probert
Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.
The American journal of pathology 1998;153(3):801-13.
1998: Lena Alexopoulou; Manolis Pasparakis; george kollias
Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function.
The Journal of experimental medicine 1998;188(4):745-54.
1998: Tonino Alonzi; Elena Fattori; Lazzaro Domenico; Patrizia Costa; L Probert; george kollias; de benedetti fabrizio; Valeria Poli; Gennaro Ciliberto
Interleukin 6 is required for the development of collagen-induced arthritis.
The Journal of experimental medicine 1998;187(4):461-8.
1998: Marco Fiore; Enrico Alleva; L Probert; george kollias; Francesco Angelucci; Luigi Aloe
Exploratory and displacement behavior in transgenic mice expressing high levels of brain TNF-alpha.
Physiology & behavior 1998;63(4):571-6.
1998: Natacha Bessis; Gilles Chiocchia; george kollias; A Minty; Catherine Fournier; Didier Fradelizi; Marie-Christophe Boissier
Modulation of proinflammatory cytokine production in tumour necrosis factor-alpha (TNF-alpha)-transgenic mice by treatment with cells engineered to secrete IL-4, IL-10 or IL-13.
Clinical and experimental immunology 1998;111(2):391-6.
1998: Theodore Tselios; Lesley Probert; george kollias; E Matsoukas; Panagiota Roumelioti; Kostas Alexopoulos; Graham J Moore; John Matsoukas
Design and synthesis of small semi-mimetic peptides with immunomodulatory activity based on myelin basic protein (MBP).
Amino acids 1998;14(4):333-41.
1997: Sabine Küsters; Gisa Tiegs; Lena Alexopoulou; Manolis Pasparakis; Eleni Douni; Gerald Künstle; Horst Bluethmann; Albrecht Wendel; Klaus Pfizenmaier; george kollias; Matthias Grell
In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.
European journal of immunology 1997;27(11):2870-5.
1997: Lena Alexopoulou; Manolis Pasparakis; george kollias
A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling.
European journal of immunology 1997;27(10):2588-92.
1997: DM Butler; Anne-Marie Malfait; LJ Mason; P J Warden; george kollias; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2867-76.
1997: J C L Plumier; A M Krueger; R William Currie; Dimitris L Kontoyiannis; george kollias; G N Pagoulatos
Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury.
Cell stress & chaperones 1997;2(3):162-7.
1997: John Ventre; Thomas W Doebber; M Wu; Karen L Macnaul; K Stevens; M Pasparakis; george kollias; David E Moller
Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.
Diabetes 1997;46(9):1526-31.
1997: Markus F Neurath; Ivan J Fuss; Manolis Pasparakis; Lena Alexopoulou; Sylva Haralambous; Karl-Hermann Meyer zum Büschenfelde; Warren Strober; george kollias
Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice.
European journal of immunology 1997;27(7):1743-50.
1997: Manolis Pasparakis; Lena Alexopoulou; Matthias Grell; Klaus Pfizenmaier; Horst Bluethmann; george kollias
Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6319-23.
1997: Andrew P Cope; Roland S Liblau; X D Yang; Mauro Congia; Carlo Laudanna; R D Schreiber; L Probert; george kollias; Hugh McDevitt
Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling.
The Journal of experimental medicine 1997;185(9):1573-84.
1997: Lesley Probert; Katerina Akassoglou; George Kassiotis; Manolis Pasparakis; Lena Alexopoulou; george kollias
TNF-alpha transgenic and knockout models of CNS inflammation and degeneration.
Journal of neuroimmunology 1997;72(2):137-41.
1997: Katerina Akassoglou; Lesley Probert; G Kontogeorgos; george kollias
Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):438-45.
1996: Manolis Pasparakis; Lena Alexopoulou; Eleni Douni; george kollias
Tumour necrosis factors in immune regulation: everything that's interesting is...new!
Cytokine & growth factor reviews 1996;7(3):223-9.
1996: Manolis Pasparakis; Lena Alexopoulou; V Episkopou; george kollias
Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.
The Journal of experimental medicine 1996;184(4):1397-411.
1996: M Fiore; L Probert; george kollias; Katerina Akassoglou; E Alleva; Luigi Aloe
Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain.
Brain, behavior, and immunity 1996;10(2):126-38.
1996: L Probert; Katerina Akassoglou; Lena Alexopoulou; Eleni Douni; Sylva Haralambous; S Hill; George Kassiotis; Dimitris L Kontoyiannis; Manolis Pasparakis; D Plows; george kollias
Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice.
Journal of leukocyte biology 1996;59(4):518-25.
1996: S Georgopoulos; D Plows; george kollias
Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice.
Journal of inflammation 1996;46(2):86-97.
1995: Matthias Grell; Eleni Douni; Harald Wajant; M Löhden; M Clauss; B Maxeiner; S Georgopoulos; W Lesslauer; george kollias; K Pfizenmaier; Peter Scheurich
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.
Cell 1995;83(5):793-802.
1995: L Probert; Katerina Akassoglou; Manolis Pasparakis; G Kontogeorgos; george kollias
Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11294-8.
1995: L Probert; D Plows; G Kontogeorgos; george kollias
The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice.
European journal of immunology 1995;25(6):1794-7.
1995: J C L Plumier; B M Ross; R William Currie; C E Angelidis; H Kazlaris; george kollias; Gerassimos N Pagoulatos
Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
The Journal of clinical investigation 1995;95(4):1854-60.
1995: Eleni Douni; Katerina Akassoglou; Lena Alexopoulou; S Georgopoulos; Sylva Haralambous; S Hill; George Kassiotis; D Kontoyiannis; Manolis Pasparakis; D Plows; L Probert; george kollias
Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.
Journal of inflammation 1995;47(1-2):27-38.
1995: Luigi Aloe; L Probert; george kollias; Alessandra Micera; Paola Tirassa
Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice.
Rheumatology international 1995;14(6):249-52.
1995: S A Siegel; D J Shealy; Marian T Nakada; J Le; Donna S Woulfe; L Probert; george kollias; J Ghrayeb; J Vilcek; P E Daddona
The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo.
Cytokine 1995;7(1):15-25.
1993: L Probert; J Keffer; P Corbella; Haris Cazlaris; E Patsavoudi; S Stephens; E Kaslaris; Dimitris Kioussis; george kollias
Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):1894-906.
1993: Luigi Aloe; L Probert; george kollias; Luisa Bracci-Laudiero; Maria Grazia Spillantini; R Levi-Montalcini
The synovium of transgenic arthritic mice expressing human tumor necrosis factor contains a high level of nerve growth factor.
Growth factors (Chur, Switzerland) 1993;9(2):149-55.
1993: Luigi Aloe; L Probert; george kollias; Luisa Bracci-Laudiero; Alessandra Micera; C Mollinari; R Levi-Montalcini
Level of nerve growth factor and distribution of mast cells in the synovium of tumour necrosis factor transgenic arthritic mice.
International journal of tissue reactions 1993;15(4):139-43.
1991: J Keffer; L Probert; Haris Cazlaris; S Georgopoulos; E Kaslaris; Dimitris Kioussis; george kollias
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
The EMBO journal 1991;10(13):4025-31.