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Tibor Kovacsovics

Research Profile

Procedures

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Chemicals & Drugs

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Physiology

Complement Pathway, Classical

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Jeffrey W Tyner; Marry M van den Heuvel-Eibrink; Wayne F Yang; Christian Michel Zwaan; Stephen T Oh; Thomas O'Hare; Stephen E Spurgeon; Armand Bankhead; Jade Bryant; Bill H Chang; Michael W Deininger; Monique L Den Boer; Brian J Druker; Guang Fan; William H Fleming; Luke B Fletcher; Jason M Glover; Jason R Gotlib; Tibor J Kovacsovics; Marc Loriaux
Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.
Theo de Witte; Anne Hagemeijer; Stefan Suciu; Amin Belhabri; Michel Delforge; Guido Kobbe; Dominik Selleslag; Harry C Schouten; Augustin Ferrant; Harald Biersack; Sergio Amadori; Petra Muus; Joop H Jansen; Eva Hellström-Lindberg; Tibor J Kovacsovics; Pierre W Wijermans; Gert Ossenkoppele; Alois Gratwohl; Jean-Pierre Marie; Roel Willemze
Value of allogeneic versus autologous stem cell transplantation and chemotherapy in patients with myelodysplastic syndromes and secondary acute myeloid leukemia. Final results of a prospective randomized European Intergroup Trial.
Valérie Frossard; Nicolas Ketterer; A Rosselet; Pascal Meier; Anne Cairoli; Michel A Duchosal; Tibor J Kovacsovics
Early intensification and autologous stem cell transplantation in patients with systemic AL amyloidosis: a single-centre experience.

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All Publications

2013: Jeffrey W Tyner; Marry M van den Heuvel-Eibrink; Wayne F Yang; Christian Michel Zwaan; Stephen T Oh; Thomas O'Hare; Stephen E Spurgeon; Armand Bankhead; Jade Bryant; Bill H Chang; Michael W Deininger; Monique L Den Boer; Brian J Druker; Guang Fan; William H Fleming; Luke B Fletcher; Jason M Glover; Jason R Gotlib; Tibor J Kovacsovics; Marc Loriaux
Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.
Cancer research 2013;73(1):285-96.
2010: Theo de Witte; Anne Hagemeijer; Stefan Suciu; Amin Belhabri; Michel Delforge; Guido Kobbe; Dominik Selleslag; Harry C Schouten; Augustin Ferrant; Harald Biersack; Sergio Amadori; Petra Muus; Joop H Jansen; Eva Hellström-Lindberg; Tibor J Kovacsovics; Pierre W Wijermans; Gert Ossenkoppele; Alois Gratwohl; Jean-Pierre Marie; Roel Willemze
Value of allogeneic versus autologous stem cell transplantation and chemotherapy in patients with myelodysplastic syndromes and secondary acute myeloid leukemia. Final results of a prospective randomized European Intergroup Trial.
Haematologica 2010;95(10):1754-61.
2009: Valérie Frossard; Nicolas Ketterer; A Rosselet; Pascal Meier; Anne Cairoli; Michel A Duchosal; Tibor J Kovacsovics
Early intensification and autologous stem cell transplantation in patients with systemic AL amyloidosis: a single-centre experience.
Annals of hematology 2009;88(7):681-5.
2009: C J Fowler; A Dunn; Brandon Hayes-Lattin; K Hansen; L Hansen; K Lanier; V Nelson; Tibor J Kovacsovics; J Leis; G Calandra; Richard T Maziarz
Rescue from failed growth factor and/or chemotherapy HSC mobilization with G-CSF and plerixafor (AMD3100): an institutional experience.
Bone marrow transplantation 2009;43(12):909-17.
2009: Jeffrey W Tyner; Michael W N Deininger; Marc Loriaux; Bill Hoon Chang; Jason R Gotlib; Stephanie G Willis; Heidi Erickson; Tibor J Kovacsovics; Thomas O'Hare; Michael C Heinrich; Brian J Druker
RNAi screen for rapid therapeutic target identification in leukemia patients.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8695-700.
2009: Laurence Senn; Tibor J Kovacsovics; Philip E Tarr; Pascal Meylan
Peritoneal tuberculosis after imatinib therapy.
Archives of internal medicine 2009;169(3):312-3.
2009: Jeffrey W Tyner; Marc Loriaux; H Erickson; C A Eide; J Deininger; Mary MacPartlin; S G Willis; Thoralf Lange; Brian J Druker; Tibor J Kovacsovics; Richard T Maziarz; N Gattermann; Michael W N Deininger
High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia.
Leukemia 2009;23(2):406-9.
2007: Emmanuelle Tavernier; Jean-Michel Boiron; Francoise Huguet; Kenneth F Bradstock; Norbert Vey; Tibor J Kovacsovics; André Delannoy; Nathalie Fegueux; Pierre Fenaux; Aspasia Stamatoullas; Olivier Tournilhac; Agnès Buzyn; Oumedaly Reman; Christiane Charrin; Claude Boucheix; Jean Gabert; Véronique Lhéritier; Jean-Paul Vernant; Hervé Dombret; Xavier Thomas
Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial.
Leukemia 2007;21(9):1907-14.
2006: Tibor J Kovacsovics; Richard T Maziarz
Philadelphia chromosome-positive acute lymphoblastic leukemia: impact of imatinib treatment on remission induction and allogeneic stem cell transplantation.
Current oncology reports 2006;8(5):343-51.
2006: Franz Buchegger; Cristian Antonescu; Angelika Bischof Delaloye; Claudine Helg; Tibor J Kovacsovics; Marek Kosinski; Jean-Pierre Mach; Nicolas Ketterer
Long-term complete responses after 131I-tositumomab therapy for relapsed or refractory indolent non-Hodgkin's lymphoma.
British journal of cancer 2006;94(12):1770-6.
2006: Nathalie Dhédin; Hervé Dombret; Xavier Thomas; Véronique Lhéritier; Jean-Michel Boiron; Françoise Rigal-Huguet; Norbert Vey; Mathieu Kuentz; Oumedaly Reman; Francis Witz; André Delannoy; Tibor J Kovacsovics; Kenneth F Bradstock; Christiane Charrin; Claude Boucheix; Jean Gabert; Didier Blaise; Denis Fière; Jean-Paul Vernant
Autologous stem cell transplantation in adults with acute lymphoblastic leukemia in first complete remission: analysis of the LALA-85, -87 and -94 trials.
Leukemia 2006;20(2):336-44.
2005: Cristian Antonescu; Angelika Bischof Delaloye; Marek Kosinski; Pascal Monnin; Andreas O Schaffland; Nicolas Ketterer; Carine Grannavel; Tibor J Kovacsovics; Francis Verdun; Franz Buchegger
Repeated injections of 131I-rituximab show patient-specific stable biodistribution and tissue kinetics.
European journal of nuclear medicine and molecular imaging 2005;32(8):943-51.
2005: Eleonora Gambillara; Emmanuel Laffitte; Nicolas Widmer; Laurent A Decosterd; Michel A Duchosal; Tibor J Kovacsovics; Renato G Panizzon
Severe pustular eruption associated with imatinib and voriconazole in a patient with chronic myeloid leukemia.
Dermatology (Basel, Switzerland) 2005;211(4):363-5.
2004: Xavier Thomas; Jean-Michel Boiron; Francoise Huguet; Hervé Dombret; Kenneth F Bradstock; Norbert Vey; Tibor J Kovacsovics; André Delannoy; Nathalie Fegueux; Pierre Fenaux; Aspasia Stamatoullas; Jean-Paul Vernant; Olivier Tournilhac; Agnès Buzyn; Oumedaly Reman; Christiane Charrin; Claude Boucheix; Jean Gabert; Véronique Lhéritier; Denis Fiere
Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(20):4075-86.
2004: Valérie Beyer; Chantal Castagné; Dominique Mühlematter; Valérie Parlier; Jürg Gmür; Urs Hess; Tibor J Kovacsovics; Sandrine Meyer-Monard; André Tichelli; Andreas Tobler; Emanuel Jacky; Urs Schanz; Mario Bargetzi; Anne Hagemeijer; Theo de Witte; Guy van Melle; Martine Jotterand
Systematic screening at diagnosis of -5/del(5)(q31), -7, or chromosome 8 aneuploidy by interphase fluorescence in situ hybridization in 110 acute myelocytic leukemia and high-risk myelodysplastic syndrome patients: concordances and discrepancies with conventional cytogenetics.
Cancer genetics and cytogenetics 2004;152(1):29-41.
2004: Michele Ghielmini; Shu-Fang Hsu Schmitz; Sergio B Cogliatti; Gabriella Pichert; Jörg Hummerjohann; Ursula Waltzer; Martin F Fey; Daniel C Betticher; Giovanni Martinelli; Fedro Alessandro Peccatori; Urs Hess; Emanuele Zucca; Roger Stupp; Tibor J Kovacsovics; Claudine Helg; Andreas Lohri; Mario Bargetzi; Daniel Vorobiof; Thomas Cerny
Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event-free survival and response duration compared with the standard weekly x 4 schedule.
Blood 2004;103(12):4416-23.
2004: Jacques Hauert; Jimena Fernandez-Carneado; Olivier Michielin; Stéphane Mathieu; Daniel Grell; Marc Schapira; Olivier Spertini; Manfred Mutter; Gabriele Tuchscherer; Tibor J Kovacsovics
A template-assembled synthetic protein surface mimetic of the von Willebrand factor A1 domain inhibits botrocetin-induced platelet aggregation.
Chembiochem : a European journal of chemical biology 2004;5(6):856-64.
2004: Nicolas Widmer; A Béguin; Bertrand Rochat; Thierry Buclin; Tibor J Kovacsovics; Michel A Duchosal; Serge Leyvraz; A Rosselet; Jérôme Biollaz; Laurent A Decosterd
Determination of imatinib (Gleevec) in human plasma by solid-phase extraction-liquid chromatography-ultraviolet absorbance detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;803(2):285-92.
2004: Nicola Gökbuget; Renato Bassan; Adriaan Dekker; Hervé Dombret; Robin Foà; Norbert Ifrah; Tibor J Kovacsovics; Boris Labar; Franco Mandelli; Giovanna Meloni; Joseph Maria Ribera; Bengt Smedmyr; Jean-Paul Vernant; Jan Walewski; Rein Willemze; Dieter Hoelzer
Developing a European network for adult ALL.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5 Suppl 3():S46-52.
2004: Nermin Halkic; Riadh Ksontini; Beatrix Scholl; Catherine Blanc; Tibor J Kovacsovics; Pascal R A Meylan; Carmen Muheim; Michel Gillet; François Mosimann
Recurrent cytomegalovirus disease, visceral leishmaniosis, and Legionella pneumonia after liver transplantation: a case report.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 2004;51(1):84-7.
2003: Bob Löwenberg; Wim L J van Putten; Matthias Theobald; Jürg Gmür; Leo F Verdonck; Pieter Sonneveld; Martin Fey; Harry Schouten; Georgine E De Greef; Augustin Ferrant; Tibor J Kovacsovics; Alois Gratwohl; S M G J Daenen; Peter C Huijgens; Marc Boogaerts
Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia.
The New England journal of medicine 2003;349(8):743-52.
2002: Michael J Keating; B Cazin; Steven Coutré; R Birhiray; Tibor J Kovacsovics; W Langer; B Leber; T Maughan; Kanti Rai; Geir Tjønnfjord; M Bekradda; M Itzhaki; P Hérait
Campath-1H treatment of T-cell prolymphocytic leukemia in patients for whom at least one prior chemotherapy regimen has failed.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(1):205-13.
2000: V Spataro; Tibor J Kovacsovics; S Bach; Sandro Pampallona; M Schapira; Franco Cavalli
Acute myeloid leukemia in the elderly: results of an individualized approach in two centres.
Leukemia & lymphoma 2000;39(5-6):521-30.
2000: Tibor J Kovacsovics
[Current treatment of AL amyloidosis].
Revue médicale de la Suisse romande 2000;120(10):771-5.
2000: P Medinger; Jean-Daniel Tissot; G Nicoloso de Faveri; Tibor J Kovacsovics; L Perey; Philippe Schneider; C Zwicky
[Autologous transplantation of peripheral blood hematopoietic stem cells in the treatment of hematological malignancies. I: patients].
Schweizerische medizinische Wochenschrift 2000;130(13):478-84.
2000: Pieter Sonneveld; A Burnett; P Vossebeld; Monique Ben-Am; G Rosenkranz; C Pfister; G Verhoef; A Dekker; G Ossenkoppele; C Ferrant; L Yin; Alois Gratwohl; Tibor J Kovacsovics; E Vellenga; Renaud Capdeville; Bob Löwenberg
Dose-finding study of valspodar (PSC 833) with daunorubicin and cytarabine to reverse multidrug resistance in elderly patients with previously untreated acute myeloid leukemia.
The hematology journal : the official journal of the European Haematology Association / EHA 2000;1(6):411-21.
2000: Jimena Fernandez-Carneado; Daniel Grell; Patricia Durieux; Jacques Hauert; Tibor J Kovacsovics; Gabriele Tuchscherer
Surface grafting onto template-assembled synthetic protein scaffolds in molecular recognition.
Biopolymers 2000;55(6):451-8.
1999: P Y Lovey; Régis Darbellay; Christine Cabrol; E Roux; Michel Starobinski; Claudine Helg; Tibor J Kovacsovics; Bernard Chapuis
BCR-negative chronic myeloid leukemia in relapse after bone marrow transplantation is susceptible to remission induction by donor lymphocyte infusions.
European journal of haematology 1999;63(4):280-1.
1997: Tibor J Kovacsovics; A Delaly
Intensive treatment strategies in multiple myeloma.
Seminars in hematology 1997;34(1 Suppl 1):49-60.
1996: John H Hartwig; S Kung; Tibor J Kovacsovics; P A Janmey; Lewis C Cantley; Thomas P Stossel; A Toker
D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate.
The Journal of biological chemistry 1996;271(51):32986-93.
1996: Tibor J Kovacsovics; John H Hartwig
Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation.
Blood 1996;87(2):618-29.
1995: A Toker; C Bachelot; C S Chen; J R Falck; John H Hartwig; Lewis C Cantley; Tibor J Kovacsovics
Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase.
The Journal of biological chemistry 1995;270(49):29525-31.
1995: Tibor J Kovacsovics; C Bachelot; A Toker; C J Vlahos; B Duckworth; Lewis C Cantley; John H Hartwig
Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation.
The Journal of biological chemistry 1995;270(19):11358-66.
1990: C Ribaux; M H Saguem; A F Allaz; Tibor J Kovacsovics
[Whipple's disease. Involvement of the small intestine with submucosal presentation].
Annales de pathologie 1990;10(3):191-3.
1988: M C Peitsch; Tibor J Kovacsovics; H Isliker
A rapid and efficient method for the purification of the complement subcomponents C1r and C1s in zymogen form using fast protein chromatography.
Journal of immunological methods 1988;108(1-2):265-9.
1987: M C Peitsch; Tibor J Kovacsovics; Jürg Tschopp; H Isliker
Antibody-independent activation of C1. II. Evidence for two classes of nonimmune activators of the classical pathway of complement.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1871-6.
1987: Tibor J Kovacsovics; M C Peitsch; A Kress; H Isliker
Antibody-independent activation of C1. I. Differences in the mechanism of C1 activation by nonimmune activators and by immune complexes: C1r-independent activation of C1s by cardiolipin vesicles.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1864-70.
1985: Tibor J Kovacsovics; Jürg Tschopp; A Kress; H Isliker
Antibody-independent activation of C1, the first component of complement, by cardiolipin.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(4):2695-700.