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Anthony Coyle

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Derek K Chu; Anthony J Coyle; Kristin Flader; Susanna Goncharova; Alison A Humbles; Roland W Kolbeck; Alba Llop-Guevara; Cheryl Lynn Moore; Tina D Walker; Susan Waserman; Tracy Seunghyun In; Jeanette E Boudreau; Manel Jordana
IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization.
Allison L Miller; Marlon C Rebelatto; Gary P Sims; Ebony Benjamin; Yambasu A Brewah; Philip Brohawn; Anthony J Coyle; Ronald Herbst; Alison A Humbles; Jennifer Kearley; Ashley E Keller; Roland Kolbeck
Opposing roles of membrane and soluble forms of the receptor for advanced glycation end products in primary respiratory syncytial virus infection.
Elizabeth Ward; Herren Wu; Michael A Bowen; Anthony J Coyle; William Dall'Acqua; Bahija Jallal; Peter Kiener; Ellen Kuta; Nanette Mittereder; Gary P Sims; Thomas Tedder; Ronald Herbst
A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo.

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All Publications

2013: Derek K Chu; Anthony J Coyle; Kristin Flader; Susanna Goncharova; Alison A Humbles; Roland W Kolbeck; Alba Llop-Guevara; Cheryl Lynn Moore; Tina D Walker; Susan Waserman; Tracy Seunghyun In; Jeanette E Boudreau; Manel Jordana
IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization.
The Journal of allergy and clinical immunology 2013;131(1):187-200.e1-8.
2012: Allison L Miller; Marlon C Rebelatto; Gary P Sims; Ebony Benjamin; Yambasu A Brewah; Philip Brohawn; Anthony J Coyle; Ronald Herbst; Alison A Humbles; Jennifer Kearley; Ashley E Keller; Roland Kolbeck
Opposing roles of membrane and soluble forms of the receptor for advanced glycation end products in primary respiratory syncytial virus infection.
The Journal of infectious diseases 2012;205(8):1311-20.
2011: Elizabeth Ward; Herren Wu; Michael A Bowen; Anthony J Coyle; William Dall'Acqua; Bahija Jallal; Peter Kiener; Ellen Kuta; Nanette Mittereder; Gary P Sims; Thomas Tedder; Ronald Herbst
A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo.
British journal of haematology 2011;155(4):426-37.
2011: Amal Al-Garawi; FM Botelho; D K Chu; Anthony J Coyle; J S Erjefalt; Ramzi Fattouh; Susanna Goncharova; Alison A Humbles; R Kolbeck; C-L Moore; M Mori; P M O'Byrne; Martin Stampfli; T D Walker; Manel Jordana
Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood.
Mucosal immunology 2011;4(6):682-94.
2011: Jodi L Karnell; Ying Li; Chris Morehouse; Bhargavi Rajan; Geoffrey L Stephens; Bonnie Swerdlow; Mildred Wilson; Raphaela Goldbach-Mansky; Christopher Groves; Ronald Herbst; Fredrick G Karnell; Anthony J Coyle; Catherine Rachel Ettinger
Mycophenolic acid differentially impacts B cell function depending on the stage of differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3603-12.
2011: F M Botelho; E S Cohen; Anthony J Coyle; N H E Davis; Alison A Humbles; Roland W Kolbeck; J K Nikota; I K Anderson; C Bauer; M R Stämpfli; Matthew Sleeman
A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;38(2):285-94.
2011: Katherine Arias; Derek K Chu; Kristin Flader; FM Botelho; Tina Walker; Natalia Arias; Alison A Humbles; Anthony J Coyle; Hans C Oettgen; Hyun-Dong Chang; Nico van Rooijen; Susan Waserman; Manel Jordana
Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice.
The Journal of allergy and clinical immunology 2011;127(6):1552-61.e1.
2011: Geoffrey L Stephens; Bonnie Swerdlow; Ebony Benjamin; Anthony J Coyle; Alison A Humbles; Roland W Kolbeck; Michael Fung
IL-9 is a Th17-derived cytokine that limits pathogenic activity in organ-specific autoimmune disease.
European journal of immunology 2011;41(4):952-62.
2011: Jennifer Kearley; Jonas S Erjefalt; Cecilia Andersson; Ebony Benjamin; Carla P Jones; Annette Robichaud; Sophie Pegorier; Yambasu Albert Brewah; Timothy J Burwell; Leif Bjermer; Peter Kiener; Roland W Kolbeck; Clare M Lloyd; Anthony J Coyle; Alison A Humbles
IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.
American journal of respiratory and critical care medicine 2011;183(7):865-75.
2011: Anthony J Coyle
Anthony Coyle.
Nature biotechnology 2011;29(3):187.
2011: Ramzi Fattouh; Amal Al-Garawi; Marcia Fattouh; Katherine Arias; Tina D Walker; Susanna Goncharova; Anthony J Coyle; Alison A Humbles; Manel Jordana
Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease.
American journal of respiratory and critical care medicine 2011;183(2):179-88.
2011: Jake K Nikota; FM Botelho; Carla Mt Bauer; Manel Jordana; Anthony J Coyle; Alison A Humbles; Martin R Stampfli
Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation.
Respiratory research 2011;12():39.
2011: Aurica G Telcian; Vasile Laza-Stanca; Michael R Edwards; James Harker; Hongwei Wang; Nathan W Bartlett; Patrick Mallia; Mihnea T Zdrenghea; Tatiana Kebadze; Anthony J Coyle; Peter J M Openshaw; Luminita A Stanciu; Sebastian L Johnston
RSV-induced bronchial epithelial cell PD-L1 expression inhibits CD8+ T cell nonspecific antiviral activity.
The Journal of infectious diseases 2011;203(1):85-94.
2010: Sebastien P Tabruyn; Katharine Colton; Tohru Morisada; Jonas Fuxe; Stanley J Wiegand; Gavin Thurston; Anthony J Coyle; Jane Connor; Donald M McDonald
Angiopoietin-2-driven vascular remodeling in airway inflammation.
The American journal of pathology 2010;177(6):3233-43.
2010: Ronald Herbst; Yue Wang; Sandra Gallagher; Nanette Mittereder; Ellen Kuta; Melissa M Damschroder; Rob Woods; Daniel Rowe; Li Cheng; Kimberly E Cook; Krista Evans; Gary P Sims; David Pfarr; Michael A Bowen; William F Dall'Acqua; William Dall'Aqua; Mark Shlomchik; Thomas F Tedder; Peter Kiener; Bahija Jallal; Herren Wu; Anthony J Coyle
B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody.
The Journal of pharmacology and experimental therapeutics 2010;335(1):213-22.
2010: Roland W Kolbeck; Alexander A Kozhich; Masamichi Koike; Li Peng; Cecilia K Andersson; Melissa M Damschroder; Jennifer L Reed; Robert M Woods; William F Dall'Acqua; Geoffrey L Stephens; Jonas S Erjefalt; Leif Bjermer; Alison A Humbles; David Gossage; Herren Wu; Peter Kiener; George L Spitalny; Charles R Mackay; Nestor A Molfino; Anthony J Coyle
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.
The Journal of allergy and clinical immunology 2010;125(6):1344-1353.e2.
2010: William W Busse; Rohit Katial; David Gossage; Suha Sari; Bing Wang; Roland W Kolbeck; Anthony J Coyle; Masamichi Koike; George L Spitalny; Peter Kiener; Gregory P Geba; Nestor A Molfino
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma.
The Journal of allergy and clinical immunology 2010;125(6):1237-1244.e2.
2010: Nassima Ferhani; Séverine Letuve; Alexander A Kozhich; Olivier Thibaudeau; Martine Grandsaigne; Marielle Maret; Marie-Christine Dombret; Gary P Sims; Roland W Kolbeck; Anthony J Coyle; Michel Aubier; Marina Pretolani
Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2010;181(9):917-27.
2010: Hans P Kiener; Gerald F M Watts; Yajun Cui; John Wright; Thomas S Thornhill; Markus Sköld; Samuel M Behar; Birgit Niederreiter; Jun Lu; Manuela Cernadas; Anthony J Coyle; Gary P Sims; Josef Smolen; Matthew L Warman; Michael B Brenner; David M Lee
Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.
Arthritis and rheumatism 2010;62(3):742-52.
2010: Séverine Létuvé; Alexander A Kozhich; Alison A Humbles; Yambasu Albert Brewah; Marie-Christine Dombret; Martine Grandsaigne; Homa Adle; Roland W Kolbeck; Michel Aubier; Anthony J Coyle; Marina Pretolani
Lung chitinolytic activity and chitotriosidase are elevated in chronic obstructive pulmonary disease and contribute to lung inflammation.
The American journal of pathology 2010;176(2):638-49.
2010: Nadege Goutagny; Zhaozhao Jiang; Jane Tian; Peggy Parroche; Jeanne H Schickli; Brian G Monks; Nancy D Ulbrandt; Hong Ji; Peter Kiener; Anthony J Coyle; Katherine A Fitzgerald
Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1168-79.
2010: Ana M Avalos; Kerstin Kiefer; Jane Tian; Sean Christensen; Mark Shlomchik; Anthony J Coyle; Ann Marshak-Rothstein
RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes.
Autoimmunity 2010;43(1):103-10.
2010: Gary P Sims; Daniel Rowe; Svend T Rietdijk; Ronald Herbst; Anthony J Coyle
HMGB1 and RAGE in inflammation and cancer.
Annual review of immunology 2010;28():367-88.
2009: Anna-Marie Fairhurst; Chun Xie; Yuyang Fu; Andrew Wang; Christopher Boudreaux; Xin J Zhou; Ricardo Cibotti; Anthony J Coyle; John E Connolly; Edward K Wakeland; Chandra Mohan
Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6831-8.
2009: Elizabeth C Nowak; Casey T Weaver; Henrietta Turner; Sakhina Begum-Haque; Burkhard Becher; Bettina Schreiner; Anthony J Coyle; Lloyd H Kasper; Randolph J Noelle
IL-9 as a mediator of Th17-driven inflammatory disease.
The Journal of experimental medicine 2009;206(8):1653-60.
2009: Katherine Arias; Moiz Baig; Marc Colangelo; Derek Chu; Tina Walker; Susanna Goncharova; Anthony J Coyle; Peter Vadas; Susan Waserman; Manel Jordana
Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions.
The Journal of allergy and clinical immunology 2009;124(2):307-14, 314.e1-2.
2009: Chiara Nembrini; Jan Kisielow; Abdijapar T Shamshiev; Luigi Tortola; Anthony J Coyle; Manfred Kopf; Benjamin J Marsland
The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses.
The Journal of biological chemistry 2009;284(29):19183-8.
2009: Mirjam Kool; Menno van Nimwegen; Monique A M Willart; Femke Muskens; Louis Boon; Joost J Smit; Anthony J Coyle; Björn E Clausen; Henk C Hoogsteden; Bart N Lambrecht; Hamida Hammad
An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1074-82.
2009: F Perros; H C Hoogsteden; Anthony J Coyle; Bart N Lambrecht; Hamida Hammad
Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation.
Allergy 2009;64(7):995-1002.
2009: Yihong Yao; Laura K Richman; Brandon W Higgs; Christopher A Morehouse; Melissa de los Reyes; Philip Brohawn; Jianliang Zhang; Barbara A White; Anthony J Coyle; Peter Kiener; Bahija Jallal
Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus.
Arthritis and rheumatism 2009;60(6):1785-96.
2009: Tatsuma Okazaki; Amy Ni; Peter Baluk; Oluwasheyi A Ayeni; Jennifer Kearley; Anthony J Coyle; Alison A Humbles; Donald M McDonald
Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice.
The American journal of pathology 2009;174(6):2388-99.
2009: Chun Geun Lee; Dominik Hartl; Gap Ryol Lee; Barbara Koller; Hiroshi Matsuura; Carla A Da Silva; Myung Hyun Sohn; Lauren Cohn; Robert J Homer; Alexander A Kozhich; Alison A Humbles; Jennifer Kearley; Anthony J Coyle; Geoffrey L Chupp; Jennifer L Reed; Richard A Flavell; Jack A Elias
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.
The Journal of experimental medicine 2009;206(5):1149-66.
2009: Kenshi Yamasaki; Jun Muto; Kristen R Taylor; Anna L Cogen; David Audish; John Bertin; Ethan P Grant; Anthony J Coyle; Amirhossein Misaghi; Hal M Hoffman; Richard L Gallo
NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.
The Journal of biological chemistry 2009;284(19):12762-71.
2009: Jennifer L Reed; Timothy P Welliver; Gary P Sims; LuAnn McKinney; Luis Velozo; Luis Avendano; Karen Hintz; Jayson Luma; Anthony J Coyle; Robert C Welliver
Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection.
The Journal of infectious diseases 2009;199(8):1128-38.
2009: Amal A Al-Garawi; Ramzi Fattouh; Tina D Walker; Erin B Jamula; Fernando Botelho; Susanna Goncharova; Jennifer L Reed; Martin Stampfli; Paul M O'Byrne; Anthony J Coyle; Manel Jordana
Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):3095-104.
2009: Yihong Yao; Brandon W Higgs; Christopher A Morehouse; Melissa de los Reyes; Wendy Trigona; Philip Brohawn; Wendy White; Jianliang Zhang; Barbara A White; Anthony J Coyle; Peter Kiener; Bahija Jallal
Development of Potential Pharmacodynamic and Diagnostic Markers for Anti-IFN-α Monoclonal Antibody Trials in Systemic Lupus Erythematosus.
Human genomics and proteomics : HGP 2009;2009():.
2008: Jennifer L Reed; Yambasu Albert Brewah; Tracy Delaney; Timothy P Welliver; Timothy J Burwell; Ebony Benjamin; Ellen Kuta; Alexander A Kozhich; LuAnn McKinney; JoAnn A Suzich; Peter Kiener; Luis Avendano; Luis Velozo; Alison A Humbles; Robert C Welliver; Anthony J Coyle
Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis.
The Journal of infectious diseases 2008;198(12):1783-93.
2008: Alex KleinJan; Monique A M Willart; Harmjan Kuipers; Anthony J Coyle; Henk C Hoogsteden; Bart N Lambrecht
Inducible costimulator blockade prolongs airway luminal patency in a mouse model of obliterative bronchiolitis.
Transplantation 2008;86(10):1436-44.
2008: Séverine Létuvé; Alexander A Kozhich; Nassim Arouche; Martine Grandsaigne; Jennifer L Reed; Marie-Christine Dombret; Peter Kiener; Michel Aubier; Anthony J Coyle; Marina Pretolani
YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):5167-73.
2008: Bo Chen; Qin Zong; Ricardo Cibotti; Chad Ryan Morris; Juana Castaneda; Brian M Naiman; Derong Liu; Anna Glodek; Gary P Sims; Ronald Herbst; stephen horrigan; Peter Kiener; Dan Soppet; Anthony J Coyle; Laurent P Audoly
Genomic-based high throughput screening identifies small molecules that differentially inhibit the antiviral and immunomodulatory effects of IFN-alpha.
Molecular medicine (Cambridge, Mass.) 2008;14(7-8):374-82.
2008: svend rietdijk; Timothy J Burwell; John Bertin; Anthony J Coyle
Sensing intracellular pathogens-NOD-like receptors.
Current opinion in pharmacology 2008;8(3):261-6.
2008: Yvonne Burmeister; Timo Lischke; Anja C Dahler; Hans W Mages; Kong-Peng Lam; Anthony J Coyle; Richard A Kroczek; Andreas Hutloff
ICOS controls the pool size of effector-memory and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):774-82.
2008: Nestor A Molfino; Anthony J Coyle
Gene-environment interactions in chronic obstructive pulmonary disease.
International journal of chronic obstructive pulmonary disease 2008;3(3):491-7.
2008: Yihong Yao; Laura K Richman; Christopher A Morehouse; Melissa de los Reyes; Brandon W Higgs; Anmarie Boutrin; Barbara A White; Anthony J Coyle; James Krueger; Peter Kiener; Bahija Jallal
Type I interferon: potential therapeutic target for psoriasis?
PloS one 2008;3(7):e2737.
2008: Alba Llop-Guevara; Marc Colangelo; Derek K Chu; Cheryl Lynn Moore; Nicole A Stieber; Tina D Walker; Susanna Goncharova; Anthony J Coyle; Lennart K A Lundblad; Paul M O'Byrne; Miroslav Lovric; Manel Jordana
In vivo-to-in silico iterations to investigate aeroallergen-host interactions.
PloS one 2008;3(6):e2426.
2007: Geoffrey L Chupp; Chun Geun Lee; Nizar N Jarjour; Yun Michael Shim; Carole T Holm; Susan He; James Dziura; Jennifer L Reed; Anthony J Coyle; Peter Kiener; Mark Cullen; Martine Grandsaigne; Marie-Christine Dombret; Michel Aubier; Marina Pretolani; Jack A Elias
A chitinase-like protein in the lung and circulation of patients with severe asthma.
The New England journal of medicine 2007;357(20):2016-27.
2007: Svetlana Chapoval; Amal Al-Garawi; Jose M Lora; Ian Strickland; Bing Ma; Patty J Lee; Robert J Homer; Sankar Ghosh; Anthony J Coyle; Jack A Elias
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):7030-41.
2007: Jiangfeng Sun; Katherine Arias; David Alvarez; Ramzi Fattouh; Tina Walker; Susanna Goncharova; Bobae Kim; Susan Waserman; Jennifer L Reed; Anthony J Coyle; Manel Jordana
Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6696-703.
2007: Jose-Angel Gonzalo; Yubin Qiu; Jose M Lora; Amal Al-Garawi; Jean-Luc Villeval; Joshua A Boyce; Carlos Martinez-A; Gabriel Márquez; Iñigo Goya; Qutayba Hamid; Christopher C Fraser; Dominic Picarella; Javier Cote-Sierra; Martin R Hodge; Jose-Carlos Gutierrez-Ramos; Roland W Kolbeck; Anthony J Coyle
Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1740-50.
2007: Bernhard Greve; Robert Weissert; Nada Hamdi; Estelle Bettelli; Raymond A Sobel; Anthony J Coyle; Vijay K Kuchroo; Klaus Rajewsky; Marc Schmidt-Supprian
I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):179-85.
2007: Qilin Pan; John C Mathison; Colleen Fearns; Vladimir V Kravchenko; Jean da Silva Correia; Hal M Hoffman; Koichi Kobayashi; John Bertin; Ethan P Grant; Anthony J Coyle; Fayyaz S Sutterwala; Yasunori Ogura; Richard A Flavell; Richard J Ulevitch
MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.
Journal of leukocyte biology 2007;82(1):177-83.
2007: Jiangfeng Sun; B Wong; Meghan Cundall; Susanna Goncharova; M Conway; A Dalrymple; Anthony J Coyle; Susan Waserman; Manel Jordana
Immunoreactivity profile of peripheral blood mononuclear cells from patients with ragweed-induced allergic rhinitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(6):901-8.
2007: Douglas F Burdi; Shannon Chi; Karen Mattia; Celeste Harrington; Zhan Shi; Shaowu Chen; Swanee Jacutin-Porte; Robert Bennett; Kenneth Carson; Wei Yin; Vikram Kansra; Jose-Angel Gonzalo; Anthony J Coyle; Bruce Jaffee; Timothy D Ocain; Martin R Hodge; Greg La Rosa; Geraldine Harriman
Small molecule antagonists of the CC chemokine receptor 4 (CCR4).
Bioorganic & medicinal chemistry letters 2007;17(11):3141-5.
2007: Jane Tian; Ana Maria Avalos; Su-Yau Mao; Bo Chen; Kannaki Senthil; Herren Wu; Peggy Parroche; Stacey V Drabic; Douglas T Golenbock; Cherilyn M Sirois; Jing Hua; Ling Ling An; Laurent P Audoly; Greg La Rosa; Angelika Bierhaus; Peter Naworth; Ann Marshak-Rothstein; Mary Crow; Katherine A Fitzgerald; Eicke Latz; Peter Kiener; Anthony J Coyle
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Nature immunology 2007;8(5):487-96.
2007: Jeffrey H Ruth; James B Rottman; Gillian A Kingsbury; Anthony J Coyle; G Kenneth Haines; Richard M Pope; Alisa E Koch
ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(5):317-26.
2007: Ivo G Boneca; Olivier Dussurget; Didier Cabanes; Marie-Anne Nahori; Sandra Sousa; Marc Lecuit; Emmanuel Psylinakis; Vassilis Bouriotis; Jean-Pierre Hugot; Marco Giovannini; Anthony J Coyle; John Bertin; Abdelkader Namane; Jean-Claude Rousselle; Nadège Cayet; Marie-Christine Prévost; Viviane Balloy; Michel Chignard; Dana J Philpott; Pascale Cossart; Stephen E Girardin
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):997-1002.
2006: Dulce Soler; Tobias R Chapman; Louis R Poisson; Lin Wang; Javier Cote-Sierra; Mark Ryan; Alice McDonald; Sunita Badola; Eric R Fedyk; Anthony J Coyle; Martin R Hodge; Roland W Kolbeck
CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6940-51.
2006: Ian R Humphreys; Lorna Edwards; Robert Snelgrove; Aaron Rae; Anthony J Coyle; Tracy Hussell
A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection.
European journal of immunology 2006;36(11):2928-38.
2006: Hemalatha Indukuri; Shawn Monique Castro; Sha-Mei Liao; Lee Ann Feeney; Marion Dorsch; Anthony J Coyle; Roberto P Garofalo; allan brasier; Antonella Casola
Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway.
Virology 2006;353(1):155-65.
2006: Harmjan Kuipers; Femke Muskens; Monique Willart; Daniëlle Hijdra; Friso B J van Assema; Anthony J Coyle; Henk C Hoogsteden; Bart N Lambrecht
Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation.
European journal of immunology 2006;36(9):2472-82.
2006: Li-Fan Lu; Evan F Lind; David C Gondek; Kathy A Bennett; Michael W Gleeson; Karina Pino-Lagos; Zachary A Scott; Anthony J Coyle; Jennifer L Reed; Jacques Van Snick; Terry B Strom; Xin Xiao Zheng; Randolph J Noelle
Mast cells are essential intermediaries in regulatory T-cell tolerance.
Nature 2006;442(7106):997-1002.
2006: Matthew C Catley; Maria B Sukkar; K Fan Chung; Bruce Jaffee; Sha-Mei Liao; Anthony J Coyle; El-Bdaoui Haddad; Peter J Barnes; Robert Newton
Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle.
Molecular pharmacology 2006;70(2):697-705.
2006: Jane A Mitchell; Katherine A Fitzgerald; Anthony J Coyle; Neal Silverman; Neil Cartwright
TOLLing away in Brazil.
Nature immunology 2006;7(7):675-9.
2006: María Lara-Tejero; Fayyaz S Sutterwala; Yasunori Ogura; Ethan P Grant; John Bertin; Anthony J Coyle; Richard A Flavell; Jorge E Galán
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.
The Journal of experimental medicine 2006;203(6):1407-12.
2006: luigi franchi; Amal Amer; Mathilde Body-Malapel; Thirumala-Devi Kanneganti; Nesrin Ozören; Rajesh Jagirdar; Naohiro Inohara; Peter Vandenabeele; John Bertin; Anthony J Coyle; Ethan P Grant; Gabriel Núñez
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.
Nature immunology 2006;7(6):576-82.
2006: Bing Ma; Wei Liu; Robert J Homer; Patty J Lee; Anthony J Coyle; Jose M Lora; Chun Geun Lee; Jack A Elias
Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4968-78.
2006: Nesrin Ozören; Junya Masumoto; luigi franchi; Thirumala-Devi Kanneganti; Mathilde Body-Malapel; Ilkim Ertürk; Rajesh Jagirdar; Li Zhu; Naohiro Inohara; John Bertin; Anthony J Coyle; Ethan P Grant; Gabriel Núñez
Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4337-42.
2006: Thirumala-Devi Kanneganti; Nesrin Ozören; Mathilde Body-Malapel; Amal Amer; Jong-Hwan Park; luigi franchi; Joel Whitfield; Winfried Barchet; Marco COLONna; Peter Vandenabeele; John Bertin; Anthony J Coyle; Ethan P Grant; Shizuo Akira; Gabriel Núñez
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
Nature 2006;440(7081):233-6.
2006: Fayyaz S Sutterwala; Yasunori Ogura; Marian Szczepanik; María Lara-Tejero; G Scott Lichtenberger; Ethan P Grant; John Bertin; Anthony J Coyle; Jorge E Galán; Philip W Askenase; Richard A Flavell
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.
Immunity 2006;24(3):317-27.
2006: Luminita A Stanciu; Cinzia M Bellettato; Vasile Laza-Stanca; Anthony J Coyle; Alberto Papi; Sebastian L Johnston
Expression of programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulator ligand on human respiratory tract epithelial cells and regulation by respiratory syncytial virus and type 1 and 2 cytokines.
The Journal of infectious diseases 2006;193(3):404-12.
2005: Bing Ma; Min Jong Kang; Chun Geun Lee; Svetlana Chapoval; Wei Liu; Qingsheng Chen; Anthony J Coyle; Jose M Lora; Dominic Picarella; Robert J Homer; Jack A Elias
Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.
The Journal of clinical investigation 2005;115(12):3460-72.
2005: Leonardo Travassos; Leticia Carneiro; Stephen E Girardin; Ivo G Boneca; Ramon Lemos; Marcelo T Bozza; Regina C P Domingues; Anthony J Coyle; John Bertin; Dana J Philpott; Maria-Cristina Plotkowski
Nod1 participates in the innate immune response to Pseudomonas aeruginosa.
The Journal of biological chemistry 2005;280(44):36714-8.
2005: Jose M Lora; Dong Mei Zhang; Sha-Mei Liao; Timothy J Burwell; Anne Marie King; Philip A Barker; Latika Singh; Marie Keaveney; Jay Morgenstern; José-Carlos Gutiérrez-Ramos; Anthony J Coyle; Christopher C Fraser
Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism.
The Journal of biological chemistry 2005;280(43):36510-7.
2005: M Cristina Lebre; Timothy J Burwell; Pedro L Vieira; Jose M Lora; Anthony J Coyle; Martien L Kapsenberg; Björn E Clausen; Esther C de Jong
Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation.
Immunology and cell biology 2005;83(5):525-35.
2005: Indira Guleria; Arezou Khosroshahi; Mohammed Javeed I Ansari; Antje Habicht; Miyuki Azuma; Hideo Yagita; Randolph J Noelle; Anthony J Coyle; Andrew L Mellor; Samia J Khoury; Mohamed H Sayegh
A critical role for the programmed death ligand 1 in fetomaternal tolerance.
The Journal of experimental medicine 2005;202(2):231-7.
2005: Miranda E A T van Berkel; Elise H R Schrijver; Frans M A Hofhuis; Arlene H Sharpe; Anthony J Coyle; Chris P M Broeren; kiki tesselaar; Mariëtte A Oosterwegel
ICOS contributes to T cell expansion in CTLA-4 deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):182-8.
2005: Duncan Howie; F Stephen Laroux; Massimo Morra; Abhay R Satoskar; Lucia E Rosas; William A Faubion; Aimee Julien; svend rietdijk; Anthony J Coyle; Christopher Fraser; Cox Terhorst
Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):5931-5.
2005: Chafen Lu; Anlai Wang; Marion Dorsch; Jane Tian; Kumiko Nagashima; Anthony J Coyle; Bruce Jaffee; Timothy D Ocain; Yajun Xu
Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity.
The Journal of biological chemistry 2005;280(16):16278-83.
2005: Yan Zheng; Monika Jost; John P Gaughan; Reiner Class; Anthony J Coyle; Marc Monestier
ICOS-B7 homologous protein interactions are necessary for mercury-induced autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):3117-21.
2005: Liqing Wang; Christopher C Fraser; Kristine Kikly; Andrew D Wells; Rongxiang Han; Anthony J Coyle; Lieping Chen; Wayne W Hancock
B7-H3 promotes acute and chronic allograft rejection.
European journal of immunology 2005;35(2):428-38.
2005: Stephen P Matthews; John Tregoning; Anthony J Coyle; Tracy Hussell; Peter J M Openshaw
Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection.
Journal of virology 2005;79(4):2050-7.
2005: David Alvarez; Greg Harder; Ramzi Fattouh; Jiangfeng Sun; Susanna Goncharova; Martin R Stämpfli; Anthony J Coyle; Jonathan Bramson; Manel Jordana
Cutaneous antigen priming via gene gun leads to skin-selective Th2 immune-inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1664-74.
2005: William J Simmons; Mythili Koneru; Mani Mohindru; Rajan Thomas; Scott Cutro; Parul Singh; Rosemarie H Dekruyff; Giorgio Inghirami; Anthony J Coyle; Byung S Kim; Nicholas M Ponzio
Tim-3+ T-bet+ tumor-specific Th1 cells colocalize with and inhibit development and growth of murine neoplasms.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1405-15.
2005: Luminita A Stanciu; Kevan Roberts; Nikolaos Papadopoulos; Sang-Heon Cho; Stephen T Holgate; Anthony J Coyle; Sebastian L Johnston
IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics.
Respiratory research 2005;6():67.
2004: Pia Svendsen; Claus B Andersen; Nick Willcox; Anthony J Coyle; Rikard Holmdahl; Thomas Kamradt; Lars Fugger
Tracking of proinflammatory collagen-specific T cells in early and late collagen-induced arthritis in humanized mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):7037-45.
2004: Elizabeth C Cates; Ramzi Fattouh; Jennifer Wattie; Mark D Inman; Susanna Goncharova; Anthony J Coyle; José-Carlos Gutierrez-Ramos; Manel Jordana
Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6384-92.
2004: Stacey A Ritz; Meghan Cundall; Beata U Gajewska; Filip K Swirski; Ryan E Wiley; David Alvarez; Anthony J Coyle; Martin Stampfli; Manel Jordana
The lung cytokine microenvironment influences molecular events in the lymph nodes during Th1 and Th2 respiratory mucosal sensitization to antigen in vivo.
Clinical and experimental immunology 2004;138(2):213-20.
2004: Jérôme Viala; Catherine Chaput; Ivo G Boneca; Ana Cardona; Stephen E Girardin; Anthony P Moran; Rafika Athman; Sylvie Mémet; Michel R Huerre; Anthony J Coyle; Peter S DiStefano; Philippe J Sansonetti; Agnès Labigne; John Bertin; Dana J Philpott; Richard L Ferrero
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island.
Nature immunology 2004;5(11):1166-74.
2004: Susumu Okamoto; Hongbin Ji; Duncan Howie; Kareem Clarke; Charles Gullo; Stephen Manning; Anthony J Coyle; Cox Terhorst
Expression of the SH2D1A gene is regulated by a combination of transcriptional and post-transcriptional mechanisms.
European journal of immunology 2004;34(11):3176-86.
2004: Hannah E Scales; Michelle X Ierna; Jose-Carlos Gutierrez-Ramos; Anthony J Coyle; Paul Garside; Catherine E Lawrence
Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis.
European journal of immunology 2004;34(10):2854-62.
2004: Lianne Wassink; Pedro L Vieira; Hermelijn H Smits; Gillian A Kingsbury; Anthony J Coyle; Martien L Kapsenberg; Eddy A Wierenga
ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1779-86.
2004: Marc Schmidt-Supprian; Jane Tian; Hongbin Ji; Cox Terhorst; Atul K Bhan; Ethan P Grant; Manolis Pasparakis; Stefano Casola; Anthony J Coyle; Klaus Rajewsky
I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1612-9.
2004: Leonie S van Rijt; Nanda Vos; Monique Willart; Alex KleinJan; Anthony J Coyle; Henk C Hoogsteden; Bart N Lambrecht
Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma.
The Journal of allergy and clinical immunology 2004;114(1):166-73.
2004: Pedro L Vieira; Lianne Wassink; L Mary Smith; Samuel Nam; Gillian A Kingsbury; Jose-Carlos Gutierrez-Ramos; Anthony J Coyle; Martien L Kapsenberg; Eddy A Wierenga
ICOS-mediated signaling regulates cytokine production by human T cells and provides a unique signal to selectively control the clonal expansion of Th2 helper cells.
European journal of immunology 2004;34(5):1282-90.
2004: Sulaiman A Nanji; Wayne W Hancock; Colin C Anderson; Andrew B Adams; Bin Luo; Colleen D Schur; Rena L Pawlick; Liqing Wang; Anthony J Coyle; Christian P Larsen; A M James Shapiro
Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(4):526-36.
2004: Marc Schmidt-Supprian; Jane Tian; Ethan P Grant; Manolis Pasparakis; Rene Maehr; Huib Ovaa; Hidde L Ploegh; Anthony J Coyle; Klaus Rajewsky
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4566-71.
2004: Anthony J Coyle; Jose-Carlos Gutierrez-Ramos
The role of ICOS and other costimulatory molecules in allergy and asthma.
Springer seminars in immunopathology 2004;25(3-4):349-59.
2004: Ype P de Jong; svend rietdijk; William A Faubion; Ana C Abadia-Molina; Kareem Clarke; Emiko Mizoguchi; Jane Tian; Tracy Delaney; Stephen Manning; Jose-Carlos Gutierrez-Ramos; Atul K Bhan; Anthony J Coyle; Cox Terhorst
Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis.
International immunology 2004;16(2):205-13.
2004: Jill R Johnson; Ryan E Wiley; Ramzi Fattouh; Filip K Swirski; Beata U Gajewska; Anthony J Coyle; José-Carlos Gutierrez-Ramos; Russ Ellis; Mark D Inman; Manel Jordana
Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling.
American journal of respiratory and critical care medicine 2004;169(3):378-85.
2003: Yolande Chvatchko; Amanda E I Proudfoot; Raphaële Buser; Pierre Juillard; Sami Alouani; Marie H Kosco-Vilbois; Anthony J Coyle; Robert J B Nibbs; Gerry Graham; Robin E Offord; Timothy Wells
Inhibition of airway inflammation by amino-terminally modified RANTES/CC chemokine ligand 5 analogues is not mediated through CCR3.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5498-506.
2003: Catherine A Sabatos; Sumone Chakravarti; Eugene Cha; Anna Schubart; Alberto Sánchez-Fueyo; Xin Xiao Zheng; Anthony J Coyle; Terry B Strom; Gordon J Freeman; Vijay K Kuchroo
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance.
Nature immunology 2003;4(11):1102-10.
2003: Alberto Sánchez-Fueyo; Jane Tian; Dominic Picarella; Christoph Domenig; Xin Xiao Zheng; Catherine A Sabatos; Natasha Manlongat; Orissa Bender; Thomas Kamradt; Vijay K Kuchroo; José-Carlos Gutiérrez-Ramos; Anthony J Coyle; Terry B Strom
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.
Nature immunology 2003;4(11):1093-101.
2003: Harmjan Kuipers; Daniëlle Hijdra; Victor C de Vries; Hamida Hammad; Jan-Bas Prins; Anthony J Coyle; Henk C Hoogsteden; Bart N Lambrecht
Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3645-54.
2003: Marc Schmidt-Supprian; Gilles Courtois; Jane Tian; Anthony J Coyle; Alain Israël; Klaus Rajewsky; Manolis Pasparakis
Mature T cells depend on signaling through the IKK complex.
Immunity 2003;19(3):377-89.
2003: Ethan P Grant; Anthony J Coyle; Jose-Carlos Gutierrez-Ramos
Informatics and the immune system: the expanding IL-1 and B7 protein families.
Seminars in immunology 2003;15(4):225-31.
2003: Anthony J Coyle; Jose-Carlos Gutierrez-Ramos
More negative feedback?
Nature immunology 2003;4(7):647-8.
2003: Stephen E Girardin; Ivo G Boneca; Leticia Carneiro; Aude Antignac; Muguette Jéhanno; Jérôme Viala; Karsten Tedin; Muhamed-Kheir Taha; Agnès Labigne; Ulrich Zähringer; Anthony J Coyle; Peter S DiStefano; John Bertin; Philippe J Sansonetti; Dana J Philpott
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan.
Science (New York, N.Y.) 2003;300(5625):1584-7.
2003: Ryan E Wiley; Susanna Goncharova; Theresa Shea; Jill R Johnson; Anthony J Coyle; Manel Jordana
Evaluation of inducible costimulator/B7-related protein-1 as a therapeutic target in a murine model of allergic airway inflammation.
American journal of respiratory cell and molecular biology 2003;28(6):722-30.
2003: Elizabeth C Cates; Beata U Gajewska; Susanna Goncharova; David Alvarez; Ramzi Fattouh; Anthony J Coyle; José-Carlos Gutierrez-Ramos; Manel Jordana
Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization.
The Journal of allergy and clinical immunology 2003;111(5):1076-86.
2003: Katherine A Fitzgerald; Sarah M McWhirter; Kerrie L Faia; Daniel Rowe; Eicke Latz; Douglas T Golenbock; Anthony J Coyle; Sha-Mei Liao; Tom Maniatis
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Nature immunology 2003;4(5):491-6.
2003: Karen M Smith; James M Brewer; Phillip Webb; Anthony J Coyle; Carlos Gutierrez-Ramos; Paul Garside
Inducible costimulatory molecule-B7-related protein 1 interactions are important for the clonal expansion and B cell helper functions of naive, Th1, and Th2 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2310-5.
2003: Iñigo Goya; Ricardo Villares; Angel Zaballos; Julio Gutiérrez; Leonor Kremer; Jose-Angel Gonzalo; Rosa Varona; Laura Carramolino; Antonio Serrano; Pilar Pallarés; Luis M Criado; Roland W Kolbeck; Miguel Torres; Anthony J Coyle; José-Carlos Gutiérrez-Ramos; Carlos Martínez-A; Gabriel Márquez
Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):2138-46.
2003: Kerstin Bonhagen; Oliver Liesenfeld; Miguel J Stadecker; Andreas Hutloff; Klaus J Erb; Anthony J Coyle; Martin Lipp; Richard A Kroczek; Thomas Kamradt
ICOS+ Th cells produce distinct cytokines in different mucosal immune responses.
European journal of immunology 2003;33(2):392-401.
2002: Elizabeth K Brint; Katherine A Fitzgerald; Philip Smith; Anthony J Coyle; Jose-Carlos Gutierrez-Ramos; Padraic G Fallon; Luke A J O'Neill
Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.
The Journal of biological chemistry 2002;277(51):49205-11.
2002: Ethan P Grant; Dominic Picarella; Timothy J Burwell; Tracy Delaney; Alisa Croci; Nicole Avitahl; Alison A Humbles; Jose-Carlos Gutierrez-Ramos; Michael Briskin; Craig Gerard; Anthony J Coyle
Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis.
The Journal of experimental medicine 2002;196(11):1461-71.
2002: Engin Ozkaynak; Liqing Wang; Andrew Goodearl; Kevin McDonald; Shixin Qin; Theresa O'Keefe; Thao Duong; Tammy Smith; Jose-Carlos Gutierrez-Ramos; James B Rottman; Anthony J Coyle; Wayne W Hancock
Programmed death-1 targeting can promote allograft survival.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6546-53.
2002: Duncan Howie; Susumo Okamoto; svend rietdijk; Kareem Clarke; Ninghai Wang; Charles Gullo; Joost P Bruggeman; Stephen Manning; Anthony J Coyle; Edward Greenfield; Vijay K Kuchroo; Cox Terhorst
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production.
Blood 2002;100(8):2899-907.
2002: Stacey A Ritz; Meghan Cundall; Beata U Gajewska; David Alvarez; José-Carlos Gutierrez-Ramos; Anthony J Coyle; Andrew N J McKenzie; Martin R Stämpfli; Manel Jordana
Granulocyte macrophage colony-stimulating factor-driven respiratory mucosal sensitization induces Th2 differentiation and function independently of interleukin-4.
American journal of respiratory cell and molecular biology 2002;27(4):428-35.
2002: Qunrui Ye; Christopher C Fraser; Wei Gao; Liqing Wang; Samantha J Busfield; Chichung Wang; Yubin Qiu; Anthony J Coyle; Jose-Carlos Gutierrez-Ramos; Wayne W Hancock
Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival.
The Journal of experimental medicine 2002;195(6):795-800.
2002: Filip K Swirski; Beata U Gajewska; David Alvarez; Stacey A Ritz; Meghan Cundall; Elizabeth C Cates; Anthony J Coyle; José-Carlos Gutierrez-Ramos; Mark D Inman; Manel Jordana; Martin R Stämpfli
Inhalation of a harmless antigen (ovalbumin) elicits immune activation but divergent immunoglobulin and cytokine activities in mice.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(3):411-21.
2002: Christopher C Fraser; Duncan Howie; Massimo Morra; Yubin Qiu; Curran Murphy; Qiong Shen; Jose-Carlos Gutierrez-Ramos; Anthony J Coyle; Gillian A Kingsbury; Cox Terhorst
Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family.
Immunogenetics 2002;53(10-11):843-50.
2002: Laurent Monney; Catherine A Sabatos; Jason L Gaglia; Akemi Ryu; Hanspeter Waldner; Tatyana Chernova; Stephen Manning; Edward Greenfield; Anthony J Coyle; Raymond A Sobel; Gordon J Freeman; Vijay K Kuchroo
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.
Nature 2002;415(6871):536-41.
2001: Massimo Morra; J Lu; Florence Poy; M Martin; Joan Sayos; Silvia Calpe; Charles Gullo; Duncan Howie; svend rietdijk; A Thompson; Anthony J Coyle; C Denny; M B Yaffe; Pablo Engel; Michael J Eck; Cox Terhorst
Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
The EMBO journal 2001;20(21):5840-52.
2001: Beata U Gajewska; Filip K Swirski; David Alvarez; Stacey A Ritz; Susanna Goncharova; Meghan Cundall; Denis Snider; Anthony J Coyle; José-Carlos Gutierrez-Ramos; Martin R Stämpfli; Manel Jordana
Temporal-spatial analysis of the immune response in a murine model of ovalbumin-induced airways inflammation.
American journal of respiratory cell and molecular biology 2001;25(3):326-34.
2001: Beata U Gajewska; David Alvarez; M Vidric; Susanna Goncharova; Martin R Stämpfli; Anthony J Coyle; José-Carlos Gutierrez-Ramos; Manel Jordana
Generation of experimental allergic airways inflammation in the absence of draining lymph nodes.
The Journal of clinical investigation 2001;108(4):577-83.
2001: James B Rottman; Tammy Smith; J R Tonra; K Ganley; T Bloom; R Silva; B Pierce; Jose-Carlos Gutierrez-Ramos; Engin Ozkaynak; Anthony J Coyle
The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE.
Nature immunology 2001;2(7):605-11.
2001: Jose-Angel Gonzalo; Jane Tian; Tracy Delaney; J Corcoran; J B Rottman; Jose M Lora; Amal Al-Garawi; R Kroczek; Jose-Carlos Gutierrez-Ramos; Anthony J Coyle
ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses.
Nature immunology 2001;2(7):597-604.
2001: Engin Ozkaynak; W Gao; N Shemmeri; C Wang; Jose-Carlos Gutierrez-Ramos; J Amaral; S Qin; James B Rottman; Anthony J Coyle; W W Hancock
Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection.
Nature immunology 2001;2(7):591-6.
2001: Alexandre Trifilieff; Yasushi Fujitani; Anthony J Coyle; M Kopf; C Bertrand
IL-5 deficiency abolishes aspects of airway remodelling in a murine model of lung inflammation.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(6):934-42.
2001: Gerhard Walzl; S Matthews; S Kendall; Jose-Carlos Gutierrez-Ramos; Anthony J Coyle; Peter J M Openshaw; Tracy Hussell
Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology.
The Journal of experimental medicine 2001;193(7):785-92.
2001: Anthony J Coyle; J C Gutierrez-Ramos
The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function.
Nature immunology 2001;2(3):203-9.
2001: Luminita A Stanciu; Kevan Roberts; L C Lau; Anthony J Coyle; Sebastian L Johnston
Induction of type 2 activity in adult human CD8(+) T cells by repeated stimulation and IL-4.
International immunology 2001;13(3):341-8.
2001: C Meisel; Kerstin Bonhagen; Max Löhning; Anthony J Coyle; JC Gutierrez-Ramos; Andreas Radbruch; Thomas Kamradt
Regulation and function of T1/ST2 expression on CD4+ T cells: induction of type 2 cytokine production by T1/ST2 cross-linking.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3143-50.
2001: Ryan E Wiley; Kay Palmer; Beata U Gajewska; Martin R Stämpfli; David Alvarez; Anthony J Coyle; José-Carlos Gutierrez-Ramos; Manel Jordana
Expression of the Th1 chemokine IFN-gamma-inducible protein 10 in the airway alters mucosal allergic sensitization in mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2750-9.
2001: Clare M Lloyd; Jose-Angel Gonzalo; T Nguyen; Tracy Delaney; Jane Tian; Hans C Oettgen; Anthony J Coyle; Jose-Carlos Gutierrez-Ramos
Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):2033-40.
2001: Clare M Lloyd; Jose-Angel Gonzalo; Anthony J Coyle; Jose-Carlos Gutierrez-Ramos
Mouse models of allergic airway disease.
Advances in immunology 2001;77():263-95.
2001: Xian Chang Li; Gülçin Demirci; Sylvie Ferrari-Lacraz; C Groves; Anthony J Coyle; Thomas R Malek; Terry B Strom
IL-15 and IL-2: a matter of life and death for T cells in vivo.
Nature medicine 2001;7(1):114-8.
2001: Jose-Angel Gonzalo; Tracy Delaney; J Corcoran; Andrew Goodearl; Jose-Carlos Gutierrez-Ramos; Anthony J Coyle
Cutting edge: the related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):1-5.
2000: Jose-Carlos Gutierrez-Ramos; C Lloyd; M L Kapsenberg; Jose-Angel Gonzalo; Anthony J Coyle
Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung.
Immunological reviews 2000;177():31-42.
2000: Anthony J Coyle; Clare M Lloyd; Jose-Carlos Gutierrez-Ramos
Biotherapeutic targets for the treatment of allergic airway disease.
American journal of respiratory and critical care medicine 2000;162(4 Pt 2):S179-84.
2000: Carl Wu; Joan Sayos; Ninghai Wang; Duncan Howie; Anthony J Coyle; Cox Terhorst
Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease.
Immunogenetics 2000;51(10):805-15.
2000: Bart N Lambrecht; M De Veerman; Anthony J Coyle; J C Gutierrez-Ramos; Kris Thielemans; Romain A Pauwels
Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation.
The Journal of clinical investigation 2000;106(4):551-9.
2000: Manfred Kopf; Anthony J Coyle; N Schmitz; M Barner; Annette Oxenius; A Gallimore; J C Gutierrez-Ramos; Martin F Bachmann
Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection.
The Journal of experimental medicine 2000;192(1):53-61.
2000: Anthony J Coyle; S Lehar; C Lloyd; Jane Tian; Tracy Delaney; Stephen Manning; T Nguyen; Timothy J Burwell; H Schneider; Jose-Angel Gonzalo; M Gosselin; L R Owen; C E Rudd; Jose-Carlos Gutierrez-Ramos
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses.
Immunity 2000;13(1):95-105.
2000: Jose-Angel Gonzalo; Clare M Lloyd; A Peled; Tracy Delaney; Anthony J Coyle; Jose-Carlos Gutierrez-Ramos
Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1 alpha in the inflammatory component of allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):499-508.
2000: Clare M Lloyd; Tracy Delaney; T Nguyen; Jane Tian; Carlos Martinez-A; Anthony J Coyle; Jose-Carlos Gutierrez-Ramos
CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo.
The Journal of experimental medicine 2000;191(2):265-74.
1999: Anthony J Coyle; C Lloyd; Jane Tian; T Nguyen; C Erikkson; L Wang; P Ottoson; P Persson; Tracy Delaney; S Lehar; S Lin; L Poisson; C Meisel; Thomas Kamradt; T Bjerke; D Levinson; Jose-Carlos Gutierrez-Ramos
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.
The Journal of experimental medicine 1999;190(7):895-902.
1999: Jose-Angel Gonzalo; Y Pan; Clare M Lloyd; G Q Jia; G Yu; BJ Dussault; C A Powers; A E Proudfoot; Anthony J Coyle; D Gearing; Jose-Carlos Gutierrez-Ramos
Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):403-11.
1999: Max Löhning; Jane Grogan; Anthony J Coyle; Maria Yazdanbakhsh; C Meisel; JC Gutierrez-Ramos; Andreas Radbruch; Thomas Kamradt
T1/ST2 expression is enhanced on CD4+ T cells from schistosome egg-induced granulomas: analysis of Th cell cytokine coexpression ex vivo.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):3882-9.
1999: A Trifilieff; Y Futjitani; Anthony J Coyle; C Bertrand
Fas-induced death of a murine pulmonary epithelial cell line: modulation by inflammatory cytokines.
Fundamental & clinical pharmacology 1999;13(6):656-61.
1999: Nicole Gerwin; Jose-Angel Gonzalo; C Lloyd; Anthony J Coyle; Yvonne Reiss; Naheed Banu; B Wang; H Xu; H Avraham; B Engelhardt; T A Springer; Jose-Carlos Gutierrez-Ramos
Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness.
Immunity 1999;10(1):9-19.
1998: Anthony J Coyle; G Köhler; S Tsuyuki; F Brombacher; M Kopf
Eosinophils are not required to induce airway hyperresponsiveness after nematode infection.
European journal of immunology 1998;28(9):2640-7.
1998: Jose-Angel Gonzalo; Clare M Lloyd; D Wen; Juan Pablo Albar; Timothy Wells; Amanda Proudfoot; Carlos Martinez-A; ME Dorf; T Bjerke; Anthony J Coyle; Jose-Carlos Gutierrez-Ramos
The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness.
The Journal of experimental medicine 1998;188(1):157-67.
1998: Max Löhning; A Stroehmann; Anthony J Coyle; Jane Grogan; S Lin; JC Gutierrez-Ramos; D Levinson; Andreas Radbruch; Thomas Kamradt
T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6930-5.
1997: Yasushi Fujitani; Alexandre Trifilieff; S Tsuyuki; Anthony J Coyle; C Bertrand
Endothelin receptor antagonists inhibit antigen-induced lung inflammation in mice.
American journal of respiratory and critical care medicine 1997;155(6):1890-4.
1997: S Tsuyuki; J Tsuyuki; K Einsle; M Kopf; Anthony J Coyle
Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness.
The Journal of experimental medicine 1997;185(9):1671-9.
1997: CH Heusser; K Wagner; J P Bews; Anthony J Coyle; C Bertrand; K Einsle; J Kips; SY Eum; Jean Lefort; B Boris Vargaftig
Demonstration of the therapeutic potential of non-anaphylactogenic anti-IgE antibodies in murine models of skin reaction, lung function and inflammation.
International archives of allergy and immunology 1997;113(1-3):231-5.
1997: Anthony J Coyle; Manfred Kopf
Lymphocyte subsets in experimental bronchopulmonary inflammation and hyperresponsiveness.
Research in immunology 1997;148(1):13-8.
1996: Anthony J Coyle; C Bertrand; S Tsuyuki; H Pircher; S Walti; Graham Le Gros; F Erard
IL-4 differentiates naive CD8+ T cells to a "Th2-like" phenotype: a link between viral infections and bronchial asthma.
Annals of the New York Academy of Sciences 1996;796():97-103.
1996: A Meyer; Anthony J Coyle; A E Proudfoot; Timothy Wells; C A Power
Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor.
The Journal of biological chemistry 1996;271(24):14445-51.
1996: Anthony J Coyle; S Tsuyuki; C Bertrand; Shau-Ku Huang; M Aguet; Sefik S Alkan; G P Anderson
Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2680-5.
1996: Anthony J Coyle; K Wagner; C Bertrand; S Tsuyuki; J Bews; C Heusser
Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody.
The Journal of experimental medicine 1996;183(4):1303-10.
1996: S Beardsell; Anthony J Coyle
A review of research on the nature and quality of HIV testing services: a proposal for process-based studies.
Social science & medicine (1982) 1996;42(5):733-43.
1996: L A Dowd; Anthony J Coyle; Jeffrey rothstein; D B Pritchett; Michael B Robinson
Comparison of Na+-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1).
Molecular pharmacology 1996;49(3):465-73.
1996: J A Ganzalo; G Q Jia; V Aguirre; D Friend; Anthony J Coyle; N A Jenkins; G S Lin; Howard Katz; A Lichtman; N Copeland; Manfred Kopf; Jose-Carlos Gutierrez-Ramos
Mouse Eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response.
Immunity 1996;4(1):1-14.
1995: Manfred Kopf; Graham Le Gros; Anthony J Coyle; Marie H Kosco-Vilbois; F Brombacher
Immune responses of IL-4, IL-5, IL-6 deficient mice.
Immunological reviews 1995;148():45-69.
1995: S Tsuyuki; C Bertrand; F Erard; A Trifilieff; J Tsuyuki; M Wesp; G P Anderson; Anthony J Coyle
Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways.
The Journal of clinical investigation 1995;96(6):2924-31.
1995: Anthony J Coyle; Graham Le Gros; C Bertrand; S Tsuyuki; C H Heusser; Manfred Kopf; G P Anderson
Interleukin-4 is required for the induction of lung Th2 mucosal immunity.
American journal of respiratory cell and molecular biology 1995;13(1):54-9.
1995: Anthony J Coyle; Steven J Ackerman; R Burch; D Proud; CG Irvin
Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation.
The Journal of clinical investigation 1995;95(4):1735-40.
1995: Anthony J Coyle; F Erard; C Bertrand; S Walti; H Pircher; Graham Le Gros
Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia.
The Journal of experimental medicine 1995;181(3):1229-33.
1995: Anthony J Coyle; S Tsuyuki
Th2 cells and cytokine networks in allergic inflammation of the lung.
Mediators of inflammation 1995;4(4):239-47.
1994: Anthony J Coyle; F Perretti; Stefano Manzini; CG Irvin
Cationic protein-induced sensory nerve activation: role of substance P in airway hyperresponsiveness and plasma protein extravasation.
The Journal of clinical investigation 1994;94(6):2301-6.
1994: Anthony J Coyle; D Uchida; Steven J Ackerman; Wayne Mitzner; CG Irvin
Role of cationic proteins in the airway. Hyperresponsiveness due to airway inflammation.
American journal of respiratory and critical care medicine 1994;150(5 Pt 2):S63-71.
1994: G P Anderson; Anthony J Coyle
TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives.
Trends in pharmacological sciences 1994;15(9):324-32.
1993: Anthony J Coyle; Wayne Mitzner; CG Irvin
Cationic proteins alter smooth muscle function by an epithelium-dependent mechanism.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(4):1761-8.
1993: D A Uchida; Steven J Ackerman; Anthony J Coyle; Gary L Larsen; Peter Weller; J Freed; CG Irvin
The effect of human eosinophil granule major basic protein on airway responsiveness in the rat in vivo. A comparison with polycations.
The American review of respiratory disease 1993;147(4):982-8.
1993: Anthony J Coyle; Steven J Ackerman; CG Irvin
Cationic proteins induce airway hyperresponsiveness dependent on charge interactions.
The American review of respiratory disease 1993;147(4):896-900.
1991: E A Seeds; Anthony J Coyle; Clive P Page
The effect of the selective PAF antagonist WEB 2170 on PAF and antigen induced airway hyperresponsiveness and eosinophil infiltration.
Journal of lipid mediators 1991;4(1):111-21.
1991: Anthony J Coyle; J Lefort; B B Vargaftig
The effect of cetirizine on antigen-dependent leucopenia in the guinea-pig.
British journal of pharmacology 1991;103(2):1520-4.
1991: Domenico Spina; M G McKenniff; Anthony J Coyle; E A Seeds; Manuela Tramontana; F Perretti; Stefano Manzini; Clive P Page
Effect of capsaicin on PAF-induced bronchial hyperresponsiveness and pulmonary cell accumulation in the rabbit.
British journal of pharmacology 1991;103(1):1268-74.
1990: Anthony J Coyle; Clive P Page; L Atkinson; R Flanagan; W James Metzger
The requirement for platelets in allergen-induced late asthmatic airway obstruction. Eosinophil infiltration and heightened airway responsiveness in allergic rabbits.
The American review of respiratory disease 1990;142(3):587-93.
1990: Anthony J Coyle; Domenico Spina; Clive P Page
PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle.
British journal of pharmacology 1990;101(1):31-8.
1989: Anthony J Coyle; Clive P Page; L Atkinson; K Sjoerdsma; C Touvay; W James Metzger
Modification of allergen-induced airway obstruction and airway hyperresponsiveness in an allergic rabbit model by the selective platelet-activating factor antagonist, BN 52021.
The Journal of allergy and clinical immunology 1989;84(6 Pt 1):960-7.
1989: Clive P Page; Anthony J Coyle
The interaction between PAF, platelets and eosinophils in bronchial asthma.
The European respiratory journal. Supplement 1989;6():483s-487s.
1989: Domenico Spina; Anthony J Coyle; C P Page
The role of platelet activating factor in allergic inflammation.
Pulmonary pharmacology 1989;2(1):13-9.
1988: D N Robertson; Anthony J Coyle; K J Rhoden; B Grandordy; Clive P Page; Peter J Barnes
The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways.
The American review of respiratory disease 1988;137(6):1317-22.
1988: Anthony J Coyle; S C Urwin; Clive P Page; C Touvay; B Villain; P Braquet
The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation.
European journal of pharmacology 1988;148(1):51-8.
1988: Clive P Page; D N Robertson; Anthony J Coyle
Drugs affecting pulmonary responses to platelet activating factor as novel anti-asthma drugs.
Agents and actions. Supplements 1988;23():173-85.