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Rafat Siddiqui

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Kevin Harvey; Candace L Walker; Phillip Whitley; Zhidong Xu; Rafat Siddiqui
Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells.
Jeffrey D Altenburg; Kevin A Harvey; Sharon McCray; Zhidong Xu; Rafat Siddiqui
A novel 2,6-diisopropylphenyl-docosahexaenoamide conjugate induces apoptosis in T cell acute lymphoblastic leukemia cell lines.
Jeffrey D Altenburg; Andrew A Bieberich; Kevin Harvey; V Jo Davisson; Colin Terry; Justin F Vanhorn; Zhidong Xu; Rafat Siddiqui
A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone.

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All Publications

2012: Kevin Harvey; Candace L Walker; Phillip Whitley; Zhidong Xu; Rafat Siddiqui
Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells.
Lipids 2012;47(7):647-57.
2011: Jeffrey D Altenburg; Kevin A Harvey; Sharon McCray; Zhidong Xu; Rafat Siddiqui
A novel 2,6-diisopropylphenyl-docosahexaenoamide conjugate induces apoptosis in T cell acute lymphoblastic leukemia cell lines.
Biochemical and biophysical research communications 2011;411(2):427-32.
2011: Jeffrey D Altenburg; Andrew A Bieberich; Kevin Harvey; V Jo Davisson; Colin Terry; Justin F Vanhorn; Zhidong Xu; Rafat Siddiqui
A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone.
BMC cancer 2011;11():149.
2010: Kevin Harvey; Candace L Walker; Zhidong Xu; Phillip Whitley; Thomas M Pavlina; Mary Hise; Gary P Zaloga; Rafat Siddiqui
Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells.
Journal of lipid research 2010;51(12):3470-80.
2010: Kevin Harvey; Zachary Welch; Daniel Sliva; Rafat Siddiqui
Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation.
Molecular and cellular biochemistry 2010;342(1-2):7-19.
2010: Kevin A Harvey; Candace L Walker; Thomas M Pavlina; Zhidong Xu; Gary P Zaloga; Rafat Siddiqui
Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth.
Clinical nutrition (Edinburgh, Scotland) 2010;29(4):492-500.
2010: Caryl J Antalis; Tyler Arnold; Tamkeen Rasool; Bonggi Lee; Kimberly Buhman; Rafat Siddiqui
High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation.
Breast cancer research and treatment 2010;122(3):661-70.
2010: Kevin A Harvey; Zhidong Xu; Phillip Whitley; V Jo Davisson; Rafat Siddiqui
Characterization of anticancer properties of 2,6-diisopropylphenol-docosahexaenoate and analogues in breast cancer cells.
Bioorganic & medicinal chemistry 2010;18(5):1866-74.
2010: Zhidong Xu; Kevin Harvey; Thomas Pavlina; Guy Dutot; Gary Zaloga; Rafat Siddiqui
An improved method for determining medium- and long-chain FAMEs using gas chromatography.
Lipids 2010;45(2):199-208.
2010: Jeffrey D Altenburg; Rafat Siddiqui
Docosahexaenoic acid downregulates interferon gamma-induced expression of CXCL16 in human aortic smooth muscle cells.
Biochemical and biophysical research communications 2010;391(1):609-14.
2009: Rafat Siddiqui; Kevin A Harvey; Nargiz Ruzmetov; Steven J Miller; Gary P Zaloga
n-3 fatty acids prevent whereas trans-fatty acids induce vascular inflammation and sudden cardiac death.
The British journal of nutrition 2009;102(12):1811-9.
2009: Rafat Siddiqui; Samira Hassan; Kevin Harvey; Tamkeen Rasool; Tapas Das; Pradip Mukerji; Stephen DeMichele
Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing mice.
The British journal of nutrition 2009;102(7):967-75.
2009: Jeffrey D Altenburg; Rafat Siddiqui
Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells.
Molecular cancer research : MCR 2009;7(7):1013-20.
2009: Caryl J Antalis; Tyler Arnold; Bonggi Lee; Kimberly Buhman; Rafat Siddiqui
Docosahexaenoic acid is a substrate for ACAT1 and inhibits cholesteryl ester formation from oleic acid in MCF-10A cells.
Prostaglandins, leukotrienes, and essential fatty acids 2009;80(2-3):165-71.
2008: Rafat Siddiqui; Kevin Harvey; Gary P Zaloga
Modulation of enzymatic activities by n-3 polyunsaturated fatty acids to support cardiovascular health.
The Journal of nutritional biochemistry 2008;19(7):417-37.
2008: Allon N Friedman; Rafat Siddiqui; Bruce A Watkins
Acute rise of omega-3 polyunsaturated fatty acids during hemodialysis treatment.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2008;18(3):301-3.
2008: Rafat Siddiqui; Kevin Harvey; William Stillwell
Anticancer properties of oxidation products of docosahexaenoic acid.
Chemistry and physics of lipids 2008;153(1):47-56.
2008: Kevin Harvey; Tyler Arnold; Tamkeen Rasool; Caryl Antalis; Steven J Miller; Rafat Siddiqui
Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction.
The British journal of nutrition 2008;99(4):723-31.
2007: Zareen Amtul; Cristian Follmer; Sumera Mahboob; Muhammad Mazhar; Khalid M Khan; Rafat Siddiqui; Sajjad Muhammad; Syed A Kazmi; M Iqbal Choudhary
Germa-gamma-lactones as novel inhibitors of bacterial urease activity.
Biochemical and biophysical research communications 2007;356(2):457-63.
2007: Kevin Harvey; Corine Nivanka Paranavitana; Gary P Zaloga; Rafat Siddiqui
Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.
Journal of cellular physiology 2007;211(2):353-63.
2007: Rafat Siddiqui; Kevin Harvey; Gary P Zaloga; William Stillwell
Modulation of lipid rafts by Omega-3 fatty acids in inflammation and cancer: implications for use of lipids during nutrition support.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2007;22(1):74-88.
2006: Michael A J Zieger; Mahesh Gupta; Rafat Siddiqui
Endothelial cell fatty acid unsaturation mediates cold-induced oxidative stress.
Journal of cellular biochemistry 2006;99(3):784-96.
2006: Gary P Zaloga; Kevin Harvey; William Stillwell; Rafat Siddiqui
Trans fatty acids and coronary heart disease.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2006;21(5):505-12.
2006: Gary P Zaloga; Nargiz Ruzmetov; Kevin Harvey; Colin Terry; Neal Patel; William Stillwell; Rafat Siddiqui
(N-3) long-chain polyunsaturated fatty acids prolong survival following myocardial infarction in rats.
The Journal of nutrition 2006;136(7):1874-8.
2006: M Ahmed Mesaik; Shahnaz Murad; Zakiah Ismail; Noor Rain Abdullah; H Kauar Gill; Muhammad Yousaf; Rafat Siddiqui; Aqeel Ahmad; M Iqbal Choudhary
Biological and molecular docking studies on coagulin-H: Human IL-2 novel natural inhibitor.
Molecular immunology 2006;43(11):1855-63.
2005: Min Wu; Kevin Harvey; Nargiz Ruzmetov; Zachary Welch; Laura Sech; Kim Jackson; William Stillwell; Gary P Zaloga; Rafat Siddiqui
Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway.
International journal of cancer. Journal international du cancer 2005;117(3):340-8.
2005: William Stillwell; Saame Raza Shaikh; Mustapha Zerouga; Rafat Siddiqui; Stephen R Wassall
Docosahexaenoic acid affects cell signaling by altering lipid rafts.
Reproduction, nutrition, development 2005;45(5):559-79.
2005: Alicia Castillo; Nargiz Ruzmetov; Kevin Harvey; William Stillwell; Gary P Zaloga; Rafat Siddiqui
Docosahexaenoic acid inhibits protein kinase C translocation/activation and cardiac hypertrophy in rat cardiomyocytes.
Journal of molecular and genetic medicine : an international journal of biomedical research 2005;1(1):18-25.
2005: Rafat Siddiqui; Mustapha Zerouga; Min Wu; Alicia Castillo; Kevin Harvey; Gary P Zaloga; William Stillwell
Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells.
Breast cancer research : BCR 2005;7(5):R645-54.
2005: Veronika Slivova; Gary P Zaloga; Stephen J DeMichele; Pradip Mukerji; Yung-Sheng Huang; Rafat Siddiqui; Kevin Harvey; Tatiana Valachovicova; Daniel Sliva
Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells.
Nutrition and cancer 2005;52(1):66-73.
2004: Rafat Siddiqui; Saame Raza Shaikh; Laura A Sech; Heidi R Yount; William Stillwell; Gary P Zaloga
Omega 3-fatty acids: health benefits and cellular mechanisms of action.
Mini reviews in medicinal chemistry 2004;4(8):859-71.
2004: Gary P Zaloga; Rafat Siddiqui
Biologically active dietary peptides.
Mini reviews in medicinal chemistry 2004;4(8):815-21.
2004: Saame Raza Shaikh; Alfred C Dumaual; Alicia Castillo; Daniel LoCascio; Rafat Siddiqui; William Stillwell; Stephen R Wassall
Oleic and docosahexaenoic acid differentially phase separate from lipid raft molecules: a comparative NMR, DSC, AFM, and detergent extraction study.
Biophysical journal 2004;87(3):1752-66.
2004: Rafat Siddiqui; Saame Raza Shaikh; Richard Kovacs; William Stillwell; Gary P Zaloga
Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid.
Journal of cellular biochemistry 2004;92(6):1141-59.
2004: Gary P Zaloga; Rafat Siddiqui; Colin Terry; Paul E Marik
Arginine: mediator or modulator of sepsis?
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2004;19(3):201-15.
2003: Saame Raza Shaikh; Alfred C Dumaual; Daniel LoCassio; Rafat Siddiqui; William Stillwell
Acyl chain unsaturation in PEs modulates phase separation from lipid raft molecules.
Biochemical and biophysical research communications 2003;311(3):793-6.
2003: Rafat Siddiqui; Laura J Jenski; Kevin Harvey; Jacqueline D Wiesehan; William Stillwell; Gary P Zaloga
Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid.
The Biochemical journal 2003;371(Pt 2):621-9.
2002: Kevin Harvey; Rafat Siddiqui; Daniel Sliva; Joe G. N. Garcia; Denis English
Serum factors involved in human microvascular endothelial cell morphogenesis.
The Journal of laboratory and clinical medicine 2002;140(3):188-98.
2002: Zareen Amtul; Atta-ur Rahman; Rafat Siddiqui; M Iqbal Choudhary
Chemistry and mechanism of urease inhibition.
Current medicinal chemistry 2002;9(14):1323-48.
2001: Rafat Siddiqui; Laura J Jenski; J D Wiesehan; M V Hunter; Richard Kovacs; William Stillwell
Prevention of docosahexaenoic acid-induced cytotoxicity by phosphatidic acid in Jurkat leukemic cells: the role of protein phosphatase-1.
Biochimica et biophysica acta 2001;1541(3):188-200.
2001: H Xiao; Rafat Siddiqui; M H Al-Hassani; Daniel Sliva; Richard Kovacs
Phospholipids released from activated platelets improve platelet aggregation and endothelial cell migration.
Platelets 2001;12(3):163-70.
2001: Rafat Siddiqui; Laura J Jenski; K Neff; Kevin Harvey; Richard Kovacs; William Stillwell
Docosahexaenoic acid induces apoptosis in Jurkat cells by a protein phosphatase-mediated process.
Biochimica et biophysica acta 2001;1499(3):265-75.
2000: Rafat Siddiqui; D J Burtschi; Richard Kovacs
Phosphatidic acid induces calcium influx in neutrophils via verapamil-sensitive calcium channels.
Journal of cellular biochemistry 2000;78(2):297-304.
2000: Rafat Siddiqui; Denis English
Phosphatidylinositol 3'-kinase-mediated calcium mobilization regulates chemotaxis in phosphatidic acid-stimulated human neutrophils.
Biochimica et biophysica acta 2000;1483(1):161-73.
1999: Denis English; A Thomas Kovala; Zachary Welch; Kevin Harvey; Rafat Siddiqui; David N Brindley; Joe G. N. Garcia
Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis.
Journal of hematotherapy & stem cell research 1999;8(6):627-34.
1999: M Bentz; Kevin Harvey; D J Burtschi; D English; Rafat Siddiqui
Induction of neutrophil calcium mobilization by phosphatidic acid-enriched plasma membranes.
IUBMB life 1999;48(2):179-85.
1999: Kevin Harvey; Rafat Siddiqui
Interleukin-8: An autocrine inflammatory mediator.
Current pharmaceutical design 1999;5(4):241-53.
1999: Rafat Siddiqui; Luke P Akard; Joe G. N. Garcia; Y Cui; Denis English
Chemotactic migration triggers IL-8 generation in neutrophilic leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1077-83.
1999: Kevin Harvey; Rafat Siddiqui; M Reeves; T Kovala; Michael J Dugan; Luke P Akard; Denis English
Characterization and partial purification of CD34+ progenitor cell ecto-phosphatidic acid phosphohydrolase.
Biochemistry and molecular biology international 1999;47(1):9-23.
1998: A Song; X L Xia; Rafat Siddiqui; Maureen A Harrington
PLA2-independent induction of CSF-1 gene expression in growth-arrested fibroblasts.
International journal of hematology 1998;67(3):249-56.
1997: Rafat Siddiqui; Denis English
Phosphatidic acid elicits calcium mobilization and actin polymerization through a tyrosine kinase-dependent process in human neutrophils: a mechanism for induction of chemotaxis.
Biochimica et biophysica acta 1997;1349(1):81-95.
1997: Y Cui; D K English; Rafat Siddiqui; M Heranyiova; Joe G. N. Garcia
Activation of endothelial cell phospholipase D by migrating neutrophils.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 1997;45(6):388-93.
1997: Denis English; M Martin; Kevin Harvey; Luke P Akard; R Allen; T S Widlanski; Joe G. N. Garcia; Rafat Siddiqui
Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase.
The Biochemical journal 1997;324 ( Pt 3)():941-50.
1996: Najia Jin; Rafat Siddiqui; Denis English; R A Rhoades
Communication between tyrosine kinase pathway and myosin light chain kinase pathway in smooth muscle.
The American journal of physiology 1996;271(4 Pt 2):H1348-55.
1996: Rafat Siddiqui; Denis English
Phosphatidic acid binding to human neutrophils: effects on tyrosine kinase-regulated intracellular Ca2+ mobilization.
Cellular signalling 1996;8(5):349-54.
1996: Kevin Harvey; Rafat Siddiqui; Jan Jansen; Luke P Akard; James M Thompson; Y Cui; Q Chang; Denis English
Growth factor induction of cytosolic protein tyrosine kinase activity in human haemopoietic progenitor cells isolated by flow cytometry.
British journal of haematology 1996;93(3):515-26.
1996: Denis English; Y Cui; Rafat Siddiqui
Messenger functions of phosphatidic acid.
Chemistry and physics of lipids 1996;80(1-2):117-32.
1996: Y Cui; Kevin Harvey; Rafat Siddiqui; Jan Jansen; Luke P Akard; James M Thompson; Joe G. N. Garcia; Denis English
Cytosolic inactivation of translocated neutrophil plasma membrane protein tyrosine phosphatase.
Blood 1996;87(1):341-9.
1995: Rafat Siddiqui; Denis English; Kevin Harvey; Y Cui; M I Martin; J Wentland; Luke P Akard; Jan Jansen; J Thompson; Joe G. N. Garcia
Phorbol ester-induced priming of superoxide generation by phosphatidic acid-stimulated neutrophils and granule-free neutrophil cytoplasts.
Journal of leukocyte biology 1995;58(2):189-95.
1995: Rafat Siddiqui; YC Yang
Interleukin-11 induces phosphatidic acid formation and activates MAP kinase in mouse 3T3-L1 cells.
Cellular signalling 1995;7(3):247-59.
1994: Y Cui; Kevin Harvey; Luke P Akard; Jan Jansen; C Hughes; Rafat Siddiqui; Denis English
Regulation of neutrophil responses by phosphotyrosine phosphatase.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5420-8.
1994: Y Cui; Denis English; S Neel; Kevin Harvey; Rafat Siddiqui; Luke P Akard; Jan Jansen; C V Hughes
Parallel up-regulation of CD11B and CD45 on neutrophilic leukocytes exposed to soluble factors of oral pathogens.
Biochemistry and molecular biology international 1994;33(1):45-54.
1994: Kevin Harvey; Y Cui; Luke P Akard; Jan Jansen; R Ash; Rafat Siddiqui; Denis English
Cytokine-stimulated up-regulation of protein tyrosine phosphatase in neutrophil plasma membranes.
Progress in clinical and biological research 1994;389():257-60.
1992: Rafat Siddiqui; John H Exton
Oleate stimulation of diacylglycerol formation from phosphatidylcholine through effects on phospholipase D and phosphatidate phosphohydrolase.
European journal of biochemistry / FEBS 1992;210(2):601-7.
1992: Rafat Siddiqui; John H Exton
Phospholipid base exchange activity in rat liver plasma membranes. Evidence for regulation by G-protein and P2y-purinergic receptor.
The Journal of biological chemistry 1992;267(9):5755-61.
1992: Rafat Siddiqui; S N McCutcheon; H T Blair; DD Mackenzie; P C Morel; Bernhard H Breier; Peter D Gluckman
Growth allometry of organs, muscles and bones in mice from lines divergently selected on the basis of plasma insulin-like growth factor-I.
Growth, development, and aging : GDA 1992;56(1):53-60.
1990: Rafat Siddiqui; J F Williams
Tentative identification of the toxohormones of cancer cachexia: roles of vasopressin, prostaglandin E2 and cachectin-TNF.
Biochemistry international 1990;20(4):787-97.
1990: Rafat Siddiqui; H T Blair; S N McCutcheon; DD Mackenzie; Peter D Gluckman; Bernhard H Breier
Developmental patterns of plasma insulin-like growth factor-I (IGF-I) and body growth in mice from lines divergently selected on the basis of plasma IGF-I.
The Journal of endocrinology 1990;124(1):151-8.
1989: U O'Sullivan; Peter D Gluckman; Bernhard H Breier; S Woodall; Rafat Siddiqui; S N McCutcheon
Insulin-like growth factor-1 (IGF-1) in mice reduces weight loss during starvation.
Endocrinology 1989;125(5):2793-4.
1989: Rafat Siddiqui; S N McCutcheon; DD Mackenzie; H T Blair; J E Ormsby; Peter D Gluckman; Bernhard H Breier
Role of testosterone in regulating the growth of mice from lines selected for low vs high plasma insulin-like growth factor-I concentrations.
Acta endocrinologica 1989;121(5):686-90.
1989: C Kroonsberg; S N McCutcheon; Rafat Siddiqui; DD Mackenzie; H T Blair; J E Ormsby; Bernhard H Breier; Peter D Gluckman
Reproductive performance and fetal growth in female mice from lines divergently selected on the basis of plasma IGF-1 concentrations.
Journal of reproduction and fertility 1989;87(1):349-53.
1989: Rafat Siddiqui; J F Williams
The regulation of fatty acid and branched-chain amino acid oxidation in cancer cachectic rats: a proposed role for a cytokine, eicosanoid, and hormone trilogy.
Biochemical medicine and metabolic biology 1989;42(1):71-86.
1988: H T Blair; S N McCutcheon; DD Mackenzie; J E Ormsby; Rafat Siddiqui; Bernhard H Breier; Peter D Gluckman
Genetic selection for insulin-like growth factor-1 in growing mice is associated with altered growth.
Endocrinology 1988;123(3):1690-2.