Rainer Fischer

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Floss Doreen M; Sack Markus; Arcalis Elsa; Stadlmann Johannes; Quendler Heribert; Rademacher Thomas; Stoger Eva; Scheller Jürgen; Fischer Rainer; Conrad Udo
Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody.
Ranft Katharina; Thepen Theo; Fischer Rainer; Barth Stefan; Stöcker Michael
Recombinant bispecific single chain antibody fragments induce Fc gamma-receptor-mediated elimination of CD30+ lymphoma cells.
Loesing Jens-Bernhard; Di Fiore Stefano; Ritter Klaus; Fischer Rainer; Kleines Michael
Epstein-Barr virus BDLF2-BMRF2 complex affects cellular morphology.

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2009: Floss Doreen M; Sack Markus; Arcalis Elsa; Stadlmann Johannes; Quendler Heribert; Rademacher Thomas; Stoger Eva; Scheller Jürgen; Fischer Rainer; Conrad Udo
Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody.
Plant biotechnology journal 2009;7(9):899-913.
2009: Ranft Katharina; Thepen Theo; Fischer Rainer; Barth Stefan; Stöcker Michael
Recombinant bispecific single chain antibody fragments induce Fc gamma-receptor-mediated elimination of CD30+ lymphoma cells.
Cancer letters 2009;282(2):187-94.
2009: Loesing Jens-Bernhard; Di Fiore Stefano; Ritter Klaus; Fischer Rainer; Kleines Michael
Epstein-Barr virus BDLF2-BMRF2 complex affects cellular morphology.
The Journal of general virology 2009;90(Pt 6):1440-9.
2009: Nölke Greta; Cobanov Pascal; Uhde-Holzem Kerstin; Reustle Götz; Fischer Rainer; Schillberg Stefan
Grapevine fanleaf virus (GFLV)-specific antibodies confer GFLV and Arabis mosaic virus (ArMV) resistance in Nicotiana benthamiana.
Molecular plant pathology 2009;10(1):41-9.
2009: Safarnejad Mohammad Reza; Fischer Rainer; Commandeur Ulrich
Recombinant-antibody-mediated resistance against Tomato yellow leaf curl virus in Nicotiana benthamiana.
Archives of virology 2009;154(3):457-67.
2008: Stahnke Bettina; Thepen Theo; Stöcker Michael; Rosinke Reinhard; Jost Edgar; Fischer Rainer; Tur Mehmet K; Barth Stefan
Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes.
Molecular cancer therapeutics 2008;7(9):2924-32.
2008: Hetzel Christian; Bachran Christopher; Fischer Rainer; Fuchs Hendrik; Barth Stefan; Stöcker Michael
Small cleavable adapters enhance the specific cytotoxicity of a humanized immunotoxin directed against CD64-positive cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(4):370-6.
2008: Nachreiner Thomas; Kampmeier Florian; Thepen Theo; Fischer Rainer; Barth Stefan; Stöcker Michael
Depletion of autoreactive B-lymphocytes by a recombinant myelin oligodendrocyte glycoprotein-based immunotoxin.
Journal of neuroimmunology 2008;195(1-2):28-35.
2008: Rademacher Thomas; Sack Markus; Arcalis Elsa; Stadlmann Johannes; Balzer Simone; Altmann Friedrich; Quendler Heribert; Stiegler Gabriela; Kunert Renate; Fischer Rainer; Stoger Eva
Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans.
Plant biotechnology journal 2008;6(2):189-201.
2008: Orecchia Martin; Nölke Greta; Saldarelli Pasquale; Dell'Orco Mariangela; Uhde-Holzem Kerstin; Sack Markus; Martelli Giovanni; Fischer Rainer; Schillberg Stefan
Generation and characterization of a recombinant antibody fragment that binds to the coat protein of grapevine leafroll-associated virus 3.
Archives of virology 2008;153(6):1075-84.
2007: Sack Markus; Paetz Antje; Kunert Renate; Bomble Michael; Hesse Friedemann; Stiegler Gabriela; Fischer Rainer; Katinger Hermann; Stoeger Eva; Rademacher Thomas
Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(8):1655-64.
2006: Renn J; Winkler C; Schartl M; Fischer R; Goerlich R
Zebrafish and medaka as models for bone research including implications regarding space-related issues.
Protoplasma 2006;229(2-4):209-14.
2006: Müller Kai J; He Xinqiang; Fischer Rainer; Prüfer Dirk
Constitutive knox1 gene expression in dandelion (Taraxacum officinale, Web.) changes leaf morphology from simple to compound.
Planta 2006;224(5):1023-7.
2006: Nölke Greta; Fischer Rainer; Schillberg Stefan
Antibody-based metabolic engineering in plants.
Journal of biotechnology 2006;124(1):271-83.
2006: Drakakaki Georgia; Marcel Sylvain; Arcalis Elsa; Altmann Friedrich; Gonzalez-Melendi Pablo; Fischer Rainer; Christou Paul; Stoger Eva
The intracellular fate of a recombinant protein is tissue dependent.
Plant physiology 2006;141(2):578-86.
2006: Schmale Kathrin; Rademacher Thomas; Fischer Rainer; Hellwig Stephan
Towards industrial usefulness - cryo-cell-banking of transgenic BY-2 cell cultures.
Journal of biotechnology 2006;124(1):302-11.
2005: Drakakaki Georgia; Marcel Sylvain; Glahn Raymond P; Lund Elizabeth K; Pariagh Sandra; Fischer Rainer; Christou Paul; Stoger Eva
Endosperm-specific co-expression of recombinant soybean ferritin and Aspergillus phytase in maize results in significant increases in the levels of bioavailable iron.
Plant molecular biology 2005;59(6):869-80.
2005: Paetz Antje; Sack Markus; Thepen Theo; Tur Mehmet K; Bruell Daniela; Finnern Ricarda; Fischer Rainer; Barth Stefan
Recombinant soluble human Fcgamma receptor I with picomolar affinity for immunoglobulin G.
Biochemical and biophysical research communications 2005;338(4):1811-7.
2005: Stöcker Michael; Klockenbring Torsten; Huhn Michael; Nachreiner Thomas; Wicklein Daniel; Petersen Arnd; Bauer Ralf; Goerlich Roland; Fischer Rainer; Barth Stefan
Antigen-specific targeting and elimination of EBV-transformed B cells by allergen toxins.
The Journal of allergy and clinical immunology 2005;116(4):910-5.
2005: Schinkel Helga; Schiermeyer Andreas; Soeur Raphael; Fischer Rainer; Schillberg Stefan
Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells.
Transgenic research 2005;14(3):251-9.
2005: von der Decken Victoria; Delbrück Heinrich; Herrler Andreas; Beier Henning M; Fischer Rainer; Hoffmann Kurt M V
Recombinant bovine uteroglobin at 1.6 A resolution: a preliminary X-ray crystallographic analysis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 5):499-502.
2005: Stoger Eva; Ma Julian K-C; Fischer Rainer; Christou Paul
Sowing the seeds of success: pharmaceutical proteins from plants.
Current opinion in biotechnology 2005;16(2):167-73.
2005: Nölke Greta; Schneider Bernd; Fischer Rainer; Schillberg Stefan
Immunomodulation of polyamine biosynthesis in tobacco plants has a significant impact on polyamine levels and generates a dwarf phenotype.
Plant biotechnology journal 2005;3(2):237-47.
2005: Schiermeyer Andreas; Schinkel Helga; Apel Stefanie; Fischer Rainer; Schillberg Stefan
Production of Desmodus rotundus salivary plasminogen activator alpha1 (DSPAalpha1) in tobacco is hampered by proteolysis.
Biotechnology and bioengineering 2005;89(7):848-58.
2005: Bruell Daniela; Bruns Christiane J; Yezhelyev Maksim; Huhn Michael; Müller Jürgen; Ischenko Ivan; Fischer Rainer; Finnern Ricarda; Jauch Karl-Walter; Barth Stefan
Recombinant anti-EGFR immunotoxin 425(scFv)-ETA' demonstrates anti-tumor activity against disseminated human pancreatic cancer in nude mice.
International journal of molecular medicine 2005;15(2):305-13.
2005: Nicholson Liz; Gonzalez-Melendi Pablo; van Dolleweerd Craig; Tuck Heidi; Perrin Yolande; Ma Julian K-C; Fischer Rainer; Christou Paul; Stoger Eva
A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells.
Plant biotechnology journal 2005;3(1):115-27.
2005: Kuepper Michael B; Huhn Michael; Spiegel Holger; Ma Julian K C; Barth Stefan; Fischer Rainer; Finnern Ricarda
Generation of human antibody fragments against Streptococcus mutans using a phage display chain shuffling approach.
BMC biotechnology 2005;5():4.
2004: Hellwig Stephan; Drossard Jürgen; Twyman Richard M; Fischer Rainer
Plant cell cultures for the production of recombinant proteins.
Nature biotechnology 2004;22(11):1415-22.
2004: Arcalis Elsa; Marcel Sylvain; Altmann Friedrich; Kolarich Daniel; Drakakaki Georgia; Fischer Rainer; Christou Paul; Stoger Eva
Unexpected deposition patterns of recombinant proteins in post-endoplasmic reticulum compartments of wheat endosperm.
Plant physiology 2004;136(3):3457-66.
2004: Klimka Alexander; Tur Mehmet K; Huhn Michael; Bierfreund Uwe; Terrada Estela; Fischer Rainer; Finnern Ricarda; Barth Stefan
Measurement of antibody-membrane interactions by surface plasmon resonance.
International journal of molecular medicine 2004;14(4):765-8.
2004: Sriraman Rajan; Bardor Muriel; Sack Markus; Vaquero Carmen; Faye Loïc; Fischer Rainer; Finnern Ricarda; Lerouge Patrice
Recombinant anti-hCG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core-alpha(1,3)-fucose residues.
Plant biotechnology journal 2004;2(4):279-87.
2004: Peschen Dieter; Li He-Ping; Fischer Rainer; Kreuzaler Fritz; Liao Yu-Cai
Fusion proteins comprising a Fusarium-specific antibody linked to antifungal peptides protect plants against a fungal pathogen.
Nature biotechnology 2004;22(6):732-8.
2004: Vogt Ulrike; Pélissier Thierry; Pütz Arno; Razvi Fareha; Fischer Rainer; Wassenegger Michael
Viroid-induced RNA silencing of GFP-viroid fusion transgenes does not induce extensive spreading of methylation or transitive silencing.
The Plant journal : for cell and molecular biology 2004;38(1):107-18.
2004: Fischer Rainer; Stoger Eva; Schillberg Stefan; Christou Paul; Twyman Richard M
Plant-based production of biopharmaceuticals.
Current opinion in plant biology 2004;7(2):152-8.
2004: Stoger Eva; Schillberg Stefan; Twyman Richard M; Fischer Rainer; Christou Paul
Antibody production in transgenic plants.
Methods in molecular biology (Clifton, N.J.) 2004;248():301-18.
2003: Tur Mehmet K; Huhn Michael; Thepen Theo; Stöcker Michael; Krohn Regina; Vogel Simon; Jost Edgar; Osieka Rainhardt; van de Winkel Jan G; Fischer Rainer; Finnern Ricarda; Barth Stefan
Recombinant CD64-specific single chain immunotoxin exhibits specific cytotoxicity against acute myeloid leukemia cells.
Cancer research 2003;63(23):8414-9.
2003: Nölke Greta; Fischer Rainer; Schillberg Stefan
Production of therapeutic antibodies in plants.
Expert opinion on biological therapy 2003;3(7):1153-62.
2003: Bruell Daniela; Stöcker Michael; Huhn Michael; Redding Nicole; Küpper Michael; Schumacher Petra; Paetz Antje; Bruns Christiane J; Haisma Hidde J; Fischer Rainer; Finnern Ricarda; Barth Stefan
The recombinant anti-EGF receptor immunotoxin 425(scFv)-ETA' suppresses growth of a highly metastatic pancreatic carcinoma cell line.
International journal of oncology 2003;23(4):1179-86.
2003: Schillberg Stefan; Fischer Rainer; Emans Neil
'Molecular farming' of antibodies in plants.
Die Naturwissenschaften 2003;90(4):145-55.
2003: Schillberg S; Fischer R; Emans N
Molecular farming of recombinant antibodies in plants.
Cellular and molecular life sciences : CMLS 2003;60(3):433-45.
2003: Fischer Rainer; Twyman Richard M; Schillberg Stefan
Production of antibodies in plants and their use for global health.
Vaccine 2003;21(7-8):820-5.
2003: Vaquero-Martin Carmen; Fischer Rainer
Production of tumor-specific antibodies in tobacco.
Methods in molecular biology (Clifton, N.J.) 2003;207():455-66.
2002: Di Fiore Stefano; Li Qiurong; Leech Mark James; Schuster Flora; Emans Neil; Fischer Rainer; Schillberg Stefan
Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype.
Plant physiology 2002;129(3):1160-9.
2002: Stoger Eva; Sack Markus; Fischer Rainer; Christou Paul
Plantibodies: applications, advantages and bottlenecks.
Current opinion in biotechnology 2002;13(2):161-6.
2002: Vaquero Carmen; Sack Markus; Schuster Flora; Finnern Ricarda; Drossard Jürgen; Schumann Detlef; Reimann Andreas; Fischer Rainer
A carcinoembryonic antigen-specific diabody produced in tobacco.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):408-10.
2002: Emans Neil; Zimmermann Sabine; Fischer Rainer
Uptake of a fluorescent marker in plant cells is sensitive to brefeldin A and wortmannin.
The Plant cell 2002;14(1):71-86.
2001: Torres E; Gonzalez-Melendi P; Stöger E; Shaw P; Twyman R M; Nicholson L; Vaquero C; Fischer R; Christou P; Perrin Y
Native and artificial reticuloplasmins co-accumulate in distinct domains of the endoplasmic reticulum and in post-endoplasmic reticulum compartments.
Plant physiology 2001;127(3):1212-23.
2001: Hellwig S; Emde F; Raven N P; Henke M; van Der Logt P; Fischer R
Analysis of single-chain antibody production in Pichia pastoris using on-line methanol control in fed-batch and mixed-feed fermentations.
Biotechnology and bioengineering 2001;74(4):344-52.
2001: Zhang M Y; Schillberg S; Zimmermann S; Liao Y C; Breuer G; Fischer R
GST fusion proteins cause false positives during selection of viral movement protein specific single chain antibodies.
Journal of virological methods 2001;91(2):139-47.
2001: Holzem A; Nähring J M; Fischer R
Rapid identification of a tobacco mosaic virus epitope by using a coat protein gene-fragment-pVIII fusion library.
The Journal of general virology 2001;82(Pt 1):9-15.
2000: Fischer R; Hoffmann K; Schillberg S; Emans N
Antibody production by molecular farming in plants.
Journal of biological regulators and homeostatic agents 2000;14(2):83-92.
2000: Stöger E; Vaquero C; Torres E; Sack M; Nicholson L; Drossard J; Williams S; Keen D; Perrin Y; Christou P; Fischer R
Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies.
Plant molecular biology 2000;42(4):583-90.
2000: Fischer R; Emans N
Molecular farming of pharmaceutical proteins.
Transgenic research 2000;9(4-5):279-99; discussion 277.
1999: Hellwig S; Robin F; Drossard J; Raven N P; Vaquero-Martin C; Shively J E; Fischer R
Production of carcinoembryonic antigen (CEA) N-A3 domain in Pichia pastoris by fermentation.
Biotechnology and applied biochemistry 1999;30 ( Pt 3)():267-75.
1999: Fischer R; Drossard J; Emans N; Commandeur U; Hellwig S
Towards molecular farming in the future: pichia pastoris-based production of single-chain antibody fragments.
Biotechnology and applied biochemistry 1999;30 ( Pt 2)():117-20.
1999: Fischer R; Vaquero-Martin C; Sack M; Drossard J; Emans N; Commandeur U
Towards molecular farming in the future: transient protein expression in plants.
Biotechnology and applied biochemistry 1999;30 ( Pt 2)():113-6.
1999: Fischer R; Emans N; Schuster F; Hellwig S; Drossard J
Towards molecular farming in the future: using plant-cell-suspension cultures as bioreactors.
Biotechnology and applied biochemistry 1999;30 ( Pt 2)():109-12.
1999: Fischer R; Drossard J; Commandeur U; Schillberg S; Emans N
Towards molecular farming in the future: moving from diagnostic protein and antibody production in microbes to plants.
Biotechnology and applied biochemistry 1999;30 ( Pt 2)():101-8.
1999: Vaquero C; Sack M; Chandler J; Drossard J; Schuster F; Monecke M; Schillberg S; Fischer R
Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11128-33.
1999: Schillberg S; Zimmermann S; Voss A; Fischer R
Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum.
Transgenic research 1999;8(4):255-63.
1999: Fischer R; Liao Y C; Hoffmann K; Schillberg S; Emans N
Molecular farming of recombinant antibodies in plants.
Biological chemistry 1999;380(7-8):825-39.
1999: Zhang M Y; Schillberg S; Prins M; Fischer R
Optimizing expression of a rare codon-rich viral protein in Escherichia coli using the IMPACT system.
Analytical biochemistry 1999;271(2):202-4.
1999: Fischer R; Schumann D; Zimmermann S; Drossard J; Sack M; Schillberg S
Expression and characterization of bispecific single-chain Fv fragments produced in transgenic plants.
European journal of biochemistry / FEBS 1999;262(3):810-6.
1999: Fischer R; Liao Y C; Drossard J
Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture.
Journal of immunological methods 1999;226(1-2):1-10.
1999: Torres E; Vaquero C; Nicholson L; Sack M; Stöger E; Drossard J; Christou P; Fischer R; Perrin Y
Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies.
Transgenic research 1999;8(6):441-9.
1998: Vaquero C; Liao Y C; Fischer R
Nonradioactive UV cross-linking assay for the study of protein-RNA binding.
BioTechniques 1998;24(1):68, 70-1.
1997: Liao Y C; Drossard J; Nähring J M; Fischer R
Isolation of RNA from plant cell suspension cultures and calli by sonication.
BioTechniques 1997;23(6):996-8, 1000.
1997: Vaquero C; Liao Y C; Nähring J; Fischer R
Mapping of the RNA-binding domain of the cucumber mosaic virus movement protein.
The Journal of general virology 1997;78 ( Pt 8)():2095-9.
1997: Schillberg S; Schumann D; Fischer R
PCR-based multiplex method for rapid screening of recombinant bacteria.
BioTechniques 1997;23(2):212-4, 216.

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Rainer Fischer

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